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Dissertations / Theses on the topic 'Health heterogeneity'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

D'Uva, Teresa Maria Marreiros Bago. "Heterogeneity in econometric analyses of health and health care." Thesis, University of York, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434129.

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2

Li, Donni Paolo. "Modelling unobserved heterogeneity in health and health care : an extended latent class approach." Thesis, University of York, 2010. http://etheses.whiterose.ac.uk/1162/.

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Unobserved heterogeneity is one of the main concerns for applied economists, this is particularly so when modelling health and health related behaviours. This thesis illustrates four studies on modelling unobserved heterogeneity using some recent developments in latent class analysis. Chapter 2 examines two sources of individual unobserved heterogeneity when subjective indicators are used to measure health status: variations in unobservable true health and differences in self-reporting behaviour for a given level of “true health”. These two sources are separately identified using both objectiv

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3

Ward, Glen Kielland. "Cellular heterogeneity in normal and neoplastic tissues." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74339.

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Heterogeneity is a ubiquitous finding in human tissues. Indeed, the cellular heterogeneity of a tumor may be viewed as a caricature of normal tissue that defines the tissue of tumor origin and prognosis. The heterogeneity of a simple tissue, bladder epithelium, has been studied with quantitative flow cytometry to measure light scattering properties and lectin binding to cells in normal and malignant tissue. It was confirmed that such quantitative assessments could be used to reveal relationships of normal tissue heterogeneity to malignant tissue heterogeneity which were relevant to both normal

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4

Dotsikas, Gus. "Cellular heterogeneity in human normal and neoplastic urothelium." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70332.

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Monoclonal antibodies (MoAbs) raised against human transitional cell carcinoma (TCC) of the urinary bladder, as well as MoAbs binding to carcinoembryonic antigen (CEA), major histocompatibility antigens and M344 (TCC-specific antigen), were used to study cellular heterogeneity in normal and neoplastic urothelium. Heterogeneity of antigen expression was related to differentiation, proliferative potential, tumor progression and clinical outcome. MoAb 5.48 binds preferentially to superficial cells of normal and neoplastic urothelium. The antigen contains terminal sialic acid, and is present on se

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5

Donni, Paolo Li. "Modelling unoserved heterogeneity in health and healthcare : An extended latent class approach." Thesis, University of York, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533491.

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6

Zicha, Stephen. "Molecular basis for ion current heterogeneity in normal and diseased hearts." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85660.

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Cardiac action potential characteristics are known to vary in different species, but also in the different regions of the heart within a given species and in cardiovascular disease. The heterologous expression of voltage-gated ion currents is believed to underlie these differences. The purpose of this thesis is to elucidate the molecular mechanisms which may underlie some of the observed current changes in different species, as well as regions and diseases of the heart.<br>Here, we describe the variable dependence on repolarizing K+ currents in different species as being the result of t

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7

Clancy, Lauren R. "Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/922.

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As our understanding of the platelet’s systemic role continues to expand beyond hemostasis and thrombosis, interrogation of the platelet’s ability to affect diverse biological processes is required. Studies of the platelet’s non-traditional roles have focused on developing our understanding of the platelet’s relation to specific disease phenotypes as well as elucidation of platelet characteristics, content, and function. The generic content, traditional function and heterogeneity of platelets have long been accepted; more ambiguous and controversial has been how these factors are interrelated.

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Clancy, Lauren R. "Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/922.

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As our understanding of the platelet’s systemic role continues to expand beyond hemostasis and thrombosis, interrogation of the platelet’s ability to affect diverse biological processes is required. Studies of the platelet’s non-traditional roles have focused on developing our understanding of the platelet’s relation to specific disease phenotypes as well as elucidation of platelet characteristics, content, and function. The generic content, traditional function and heterogeneity of platelets have long been accepted; more ambiguous and controversial has been how these factors are interrelated.

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9

Bigdeli, T. Bernard. "Quantitative Genetic Methods to Dissect Heterogeneity in Complex Traits." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2651.

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Etiological models of complex disease are elusive[46, 33, 9], as are consistently replicable findings for major genetic susceptibility loci[54, 14, 15, 24]. Commonly-cited explanations invoke low-frequency genomic variation[41], allelic heterogeneity at susceptibility loci[33, 30], variable etiological trajectories[18, 17], and epistatic effects between multiple loci; these represent among the most methodologically-challenging issues in molecular genetic studies of complex traits. The response has been con- sistently reactionary—hypotheses regarding the relative contributions of known func- ti

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10

Smith, Mathew Arjuna. "Africans in Scotland : heterogeneity and sensitivities to HIV." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7668/.

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Aim: To investigate how diversity within the African migrant population in Scotland affects their understandings of HIV and uptake of HIV testing and treatment, in order to improve HIV-related outcomes. Background: In the UK, Africans have the worst outcomes for HIV infection, primarily due to late diagnosis. Improvement requires better understanding of the barriers to healthcare engagement. This PhD study investigates how diversity among first generation African migrants in Scotland could affect engagement with general healthcare and HIV related interventions and services. Methods: I conducte

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11

Sakr, Lama. "Phenotypic heterogeneity of potentially curable non-small cell lung cancer: cohort study with cluster analysis." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116984.

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Background: The Tumor, Node, Metastasis (TNM) staging system in non-small cell lung cancer (NSCLC) is currently the most reliable prognostic tool. However, significant differences in clinical course and outcome are observed among patients with apparent curable disease by TNM staging. A more elaborate classification system that simultaneously incorporates the various facets of NSCLC may help identify specific disease patterns, therefore providing a more reliable prediction of outcome. Objectives: 1) to classify patients with potentially curable NSCLC into distinct phenotypic groups using cluste

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12

Ulbricht, Christine M. "Latent Variable Approaches for Understanding Heterogeneity in Depression: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/774.

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Background: Major depression is one of the most prevalent, disabling, and costly illnesses worldwide. Despite a 400% increase in antidepressant medication use since 1988, fewer than half of treated depression patients experience a clinically meaningful reduction in symptoms and uncertainty exists regarding how to successfully obtain symptom remission. Identifying homogenous subgroups based on clinically observable characteristics could improve the ability to efficiently predict who will benefit from which treatments. Methods: Latent class analysis and latent transition analysis (LTA) were appl

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13

Reinhardt, Julia. "Multidimensional assessment of heterogeneity of human CD4+CD25+ T cells in health and Type 1 Diabetes." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-234017.

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Background Regulatory T cells (Treg) are a subpopulation of CD4+ T cells that play an important role in the peripheral tolerance mechanisms of the immune system. Their suppressive function on autoreactive T cells can prevent autoimmunity. In type 1 diabetes (T1D), Treg have been inconsistently reported to be impaired in their capability to suppress autoreactive T cells (Tan, et al., 2014; Zhang, et al., 2012). Treg can be thymus derived (tTreg) or generated from naïve CD4+ CD25- T cells in the periphery (pTreg), which exhibit similar suppressive qualities as tTreg. They have also been reported

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14

Graham, Matthew. "The impact of heterogeneity in contact structure on the spread of infectious diseases." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66543/.

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Contact structure between individuals in a population has a large impact on the spread of an epidemic within this population. Many techniques and models are used to investigate this, from heterogeneous age-age mixing matrices to the use of network models in order to quantify the heterogeneity in the populations contacts. For many diseases, the probability of infection per contact, along with the exact contact structure are unknown, compounding the difficulty of identifying accurate contact structures. In this thesis, the impact that the contact structure has on the epidemic is examined in seve

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15

Kudamatsu, Masayuki. "Political economy of development : health as a development outcome, micro evidence, and heterogeneity of democracies and autocracies." Thesis, London School of Economics and Political Science (University of London), 2007. http://etheses.lse.ac.uk/2020/.

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The thesis explores whether and how democratic and autocratic political institutions affect the welfare of people in developing countries. First, we empirically investigate whether democracy improves people's health, by using time-series country-level aggregate statistics. We find that there is a robust cross-sectional correlation between democracy and life expectancy at birth. Country fixed effects estimation, on the other hand, does not yield a statistically significant correlation between the two. This empirical approach, however, does not disentangle the effect of democracy from country-le

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16

Melnychuk, Mariya. "Three essays on health economics." Doctoral thesis, Universidad de Alicante, 2013. http://hdl.handle.net/10045/35560.

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17

Arnold, Cody. "What's wrong with the concept of "very low birthweight"? : heterogeneity and confounding in epidemiologic studies of very small or immature neonates." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59301.

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We divided 640 consecutively live-born newborns into two overlapping groups: a traditional very low birthweight (BW) cohort (500-1500 g, mean BW 1055 g) and a gestational age (GA) cohort (23-30 weeks, mean BW 1070 g). We showed: (1) An illusory protective effect of intrauterine growth retardation (IUGR) for in-hospital mortality in the 500-1500 cohort: odds ratio (OR), 0.55. In the 23-30 cohort the crude OR was 1.19; adjusting for differences in GA between IUGR and non-IUGR infants resulted in an odds ratio of 3.15 (95% C.I., 1.57-6.32). (2) Confounding by growth status was demonstrated in a h

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18

Chen, Wen. "REGIONAL HETEROGENEITY AND DIVERSITY OF ASTROCYTES IN RESPONSE TO HIV-1 PROTEINS AND MORPHINE." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2263.

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HIV-infected individuals who abuse opiates have been found to have a higher incidence and a faster progression of HIV encephalitis. Astrocytes, the major support cells in the CNS, are known to play a critical role in the HIV neuropathy. Although astrocytes tend not to be productively infected by the HIV-1 virus, dysregulation of their pro- and anti- inflammatory cytokines/chemokines secretion is usually neurotoxic. Glutamate transport in astrocytes is reported to be impaired as well, which result in extrasynaptic excitatory neurotransmitter accumulation and over stimulation of postsynaptic neu

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19

Wallbing, Linus. "Characterization of heterogeneity of biomolecular interactions using 3rd generation biosensor." Thesis, KTH, Skolan för kemivetenskap (CHE), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215130.

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A new tool for kinetic evaluation of kinetic rate constants is enabled by a 3rd generation biosensor. The tool is developed to meet the need of reliably experimental information and communication between pharmaceutical companies and regulatory agencies to increase the productivity and decrease the associated risks. Too obtain the necessary competences and resources for this, a project consisting of Attana AB, AstraZeneca AB, Waters Nordic AB and Karlstad University was established. The main aim of the project is to achieve a comprehension understanding of interactions of different character e.

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20

Tarrence, Jacob. "Struggling in The Land of Opportunity: Examining Racial Heterogeneity in The Effects of Intergenerational Educational Mobility On Health." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1530873594596853.

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21

Dumont, Alain. "Insights into the dynamics of T cell clonal expansion and the functional heterogeneity of memory CD4 T lymphocytes using superantigens." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84235.

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Superantigens trigger the polyclonal activation of human T cells. We exploited this property to gain insight into the mechanisms governing CD4 T cell expansion and to study the functional heterogeneity of naive and memory CD4 T cell subsets. We show that the amount of TCR ligand affects the evolution of a T cell response in two ways: by shaping the diversity of the T cell population recruited in the proliferative pool and by affecting the progression of these precursors into cell cycle. These two processes characterize a hierarchy of recruitment of cells that strongly correlates with th

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22

Niehaus, Daniel Jan Hendrik. "Limiting clinical heterogeneity in schizophrenia : can affected Xhosa sib pairs provide valid subtypes?" Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/1435.

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Thesis (DMed (Psychiatry))--University of Stellenbosch, 2005.<br>BACKGROUND Schizophrenia is a heterogeneous disorder, which has been shown to have both environmental and genetic risk factors. Since family history (genetic loading) of psychosis appears to be one of the strongest risk factors for the development of schizophrenia, the investigation of affected sib pairs can be used to explore shared familial factors. The Xhosa-speaking inhabitants in the Western, Eastern and Southern Cape provinces, an African population of relatively homogeneous ethnicity, provided a sample of the first large

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23

Bernhard-Oettel, Claudia. "Alternative employment and well-being : Contract heterogeneity and differences among individuals." Doctoral thesis, Stockholm : Department of Psychology, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8030.

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24

Karlsson, Henrik. "Examining sources of heterogeneity between studies of mental-health outcomes in children with experience of foster care – a meta-analytical approach." Thesis, Stockholms universitet, Institutionen för folkhälsovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157025.

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Systematic reviews of the effect of foster care on mental-health outcomes have consistently indicated a zero-sum game, which makes it unclear whether the intervention is suitable for children in need of out-of-home placements. This thesis took on a meta-analytical approach to examine sources of heterogeneity between studies evaluating the effect of foster care on adaptive functioning, cognitive functioning, externalizing behavior, internalizing behavior, and total problems behavior. The bulk of studies came from two recently published systematic reviews. The searches were replicated to cover s

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25

Herrick, Andrea Celeste. "A Comparative Dosimetric Analysis of the Effect of Heterogeneity Corrections Used in Three Treatment Planning Algorithms." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1290427283.

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26

Ullsten, Sara. "The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330805.

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Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. In type 1 diabetes, the insulin producing beta cells are all destroyed within some islets, and similarly in type 2 diabetes, some islets may be severely affected by amyloid. At the same time other islets, in the near vicinity of the ones that are affected by disease, may appear fully normal

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27

Momplaisir, Hans. "Racial/Ethnic Heterogeneity, Religion, and Mental Health: Examining the Influence of Religiosity on African American and Afro-Caribbean Subjective Well-Being." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/83870.

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Religion is important to most African Americans and Afro-Caribbeans. Church attendance is positively associated with aspects of subjective well-being. However, research concerning the influence of religiosity on African Americans' and Afro-Caribbeans' subjective well-being is scarce. Research into whether measures other than church attendance is positively linked to measures of subjective well-being is thin. In addition, investigations into which mechanisms shape religion's impact on subjective well-being for both groups are also lacking. Next, investigations into whether religiosity buffers t

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Espinoza, Manuel Antonio. "Heterogeneity in cost-effectiveness analysis : methods to explore the value of subgroups and individualized care in a collectively funded health system." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3157/.

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Cost-effectiveness analysis is increasingly being used to support decisions about the allocation of resources in health systems. However, decisions based on cost-effectiveness are usually made under imperfect and incomplete information. This thesis examines the value of understanding and characterizing heterogeneity for decision-making in healthcare. It proposes a methodological framework for a systematic cost-effectiveness subgroup analysis, providing guidance for identification and selection of subgroups. It suggests that the value of heterogeneity should be examined considering two dimensio

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Obisesan, Olawunmi. "Predictors of Obesity Among Nigerian Immigrants in the United States." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/378.

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Obesity has been identified as a significant risk factor for chronic diseases, contributing to health disparities in minority and vulnerable populations. Though research has identified an increased risk for obesity in the Hispanic immigrant population, there is little or no research on the heterogeneity of obesity predictors in specific immigrant populations in the United States. This study examined the predictors of obesity in the Nigerian immigrant population in the United States. Guided by the social ecological model and the segmented assimilation theory, this cross-sectional study collecte

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Sawvel, Eric J. "Use Of passive samplers to characterize the spatial heterogeneity of coarse particle mass concentration and composition in Cleveland, OH." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/5053.

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The overall goals of this dissertation are: 1) to better quantify the spatial heterogeneity of coarse particulate matter (PM10-2.5) and its chemical composition; and 2) to evaluate the performance (accuracy and precision) of passive samplers analyzed by computer-controlled scanning electron microscopy with energy-dispersive X-ray spectroscopy (CCSEM-EDS) for PM10-2.5. For these goals, field studies were conducted over multiple seasons in Cleveland, OH and were the source of data for this dissertation. To achieve the first goal, we characterized spatial variability in the mass and composition o

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31

Reinhardt, Julia [Verfasser], Ezio [Akademischer Betreuer] Bonifacio, Ezio [Gutachter] Bonifacio, and Michael [Gutachter] Bachmann. "Multidimensional assessment of heterogeneity of human CD4+CD25+ T cells in health and Type 1 Diabetes / Julia Reinhardt ; Gutachter: Ezio Bonifacio, Michael Bachmann ; Betreuer: Ezio Bonifacio." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1156169496/34.

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Powell, James Patrick. "Antibiotic Diversity and Bacterial Resistance." Available to users online at:, 2007. http://hdl.handle.net/10156/1303.

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Akoma, Efua Safiya. "Rates of Mental Illnesses, Nativity and Generational Status in the U.S.: Heterogeneity among Caribbean Born Blacks, Blacks of Caribbean Descent and U.S. Born Blacks." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/51746.

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America has continued to be increasingly diverse in culture and ethnicities. As such, these diverse populations require those in health and mental health fields to adjust to the cultural differences that arise. Central to these conversations is the impact of the acculturation process on immigrant populations. Researchers posit the stress of immigration and the acculturation process leads to increased rates of mental illness (Lang, Munoz, Bernal and Sorenson 1982; Masten, Penland and Nayani 1994; Neff and Hoppe 1993). Assuming that the acculturation process impacts first generation immigrants m

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34

Thunström, Linda. "Food consumption, paternalism and economic policy." Doctoral thesis, Umeå University, Economics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1654.

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<p>The thesis consists of a summary and four papers, concerned with food consumption, behavior associated with overconsumption of food and analysis of the economic policy reforms designed to improve health.</p><p>Paper [I] estimates a hedonic price model on breakfast cereal, crisp bread and potato product data. The purpose is to examine the marginal implicit prices for food characteristics associated with health. A trade-off exists between health and taste. For instance, sugar, salt and fat are tasty but can be unhealthy if overconsumed; whereas fiber is unhealthy if underconsumed. If the marg

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Weinberger, Michael. "Epicardial heterogeneity during zebrafish heart development." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:3f26b933-5f17-4fe3-bd86-9211af69a558.

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The epicardium, a cell layer enveloping the heart muscle, drives embryonic heart development and heart repair in the adult zebrafish. Previous studies found the epicardium to consist of multiple cell populations with distinct phenotypes and functions. Here, I investigated epicardial heterogeneity in the developing zebrafish heart, focusing on the developmental gene program that is also reactivated during adult heart regeneration. Transcription factor 21 (Tcf21), T-box 18 (Tbx18) and Wilms' tumor suppressor 1b (Wt1b) are often used interchangeably to identify the zebrafish epicardium. Analyzing

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36

Wang, Binghui. "INFLUENCE OF SURFACE MODIFICATION ON PROPERTIES AND APPLICATIONS OF COMPLEX ENGINEERED NANOPARTICLES." UKnowledge, 2013. http://uknowledge.uky.edu/cme_etds/24.

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Complex engineered nanoparticles (CENPs) are being used on various applications. Their properties are different from those of neat nanoparticles. The dissertation explores these differences from four aspects: 1) Modify carbon nanomaterials’ inert surfaces and investigate the effect on thermal and rheological behavior of their dispersions; 2) Generate self-assembly bi-layer structure of oxide nanoparticles via surface modification; 3) Study interaction between lysozyme and different surface-charged ceria nanoparticles; 4) Investigate the biodistribution and transformations of CENPs in biologica

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Figueiredo, Valeska Carvalho. "Um panorama do tabagismo em 16 capitais brasileiras e Distrito Federal: tendências e heterogeneidades." Universidade do Estado do Rio de Janeiro, 2007. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4415.

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Esta tese inclui dois artigos que têm por objetivo apresentar um panorama das tendências e heterogeneidades do tabagismo nas capitais brasileiras e, assim, oferecer subsídios ao planejamento e avaliação de medidas de controle do tabaco no País. Utilizaram-se os dados da Pesquisa Nacional sobre Saúde e Nutrição (PNSN), e do Inquérito Domiciliar Sobre Comportamentos de Risco e Morbidade Referida de Doenças e Agravos Não Transmissíveis (InqDANT). No primeiro artigo estimou-se a diferença na prevalência de tabagismo em 14 capitais brasileiras entre pessoas de 15 anos ou mais em 1989 (PNSN) e 200

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Magosi, Lerato Elaine. "Dissecting heterogeneity in GWAS meta-analysis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:c853f7e7-93de-440c-b57c-fcfc03d3bb86.

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Statistical heterogeneity refers to differences among results of studies combined in a meta-analysis beyond that expected by chance. On the one hand, excessive heterogeneity can diminish power to discover genetic signals; on the other, moderate heterogeneity can reveal important biological differences among studies. Given its double-edged nature, this thesis dissects heterogeneity in genetic association meta-analyses from three vantage points. First, a novel multi-variant statistic, M is proposed to detect genome-wide (systematic) heterogeneity patterns in genetic association meta-analyses. Th

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Haynes, Premi. "TRANSMURAL HETEROGENEITY OF CELLULAR LEVEL CARDIAC CONTRACTILE PROPERTIES IN AGING AND HEART FAILURE." UKnowledge, 2014. http://uknowledge.uky.edu/physiology_etds/16.

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The left ventricle of the heart relaxes when it fills with blood and contracts to eject blood into circulation to meet the body’s metabolic demands. Dysfunction in either relaxation or contraction of the left ventricle can lead to heart failure. Transmural heterogeneity is thought to contribute to normal ventricular wall motion but it is not well understood how transmural modifications affect the failing left ventricle. The overall hypothesis of this dissertation is that normal left ventricles exhibit transmural heterogeneity in cellular level contractile properties and with aging and heart fa

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Caslake, Muriel. "Studies on the structural and metabolic heterogeneity in low density lipoprotein." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321063.

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Blyth, Eleanor M. "The effect of small scale heterogeneity on surface heat and moisture fluxes." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239806.

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Jaya, Seelan Palaniappan. "Revealing the heterogeneity in weld microstructures using the thermomechanical dissipative heat source." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/427157/.

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Mechanical deformation of a metal is accompanied by the dissipation of energy in the form of heat as a result of thermodynamically irreversible processes occurring at the microscale. This is applicable to deformation in both elastic and plastic regime so long as the thermodynamically irreversible processes are activated. It follows that there is a possibility of identifying the condition of the material microstructure by evaluating the heat dissipated during deformation. In the thesis, the continuous temperature rise due to the heat dissipation in a material under cyclic loading is obtained us

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Main, Malcolm Charles. "Regional heterogeneity in electrophysiological and mechanical characteristics of left ventricular myocytes." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360416.

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Ala-Kopsala, M. (Minna). "Circulating N-terminal fragments of A- and B-type natriuretic peptides: molecular heterogeneity, measurement and clinical application." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282469.

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Abstract Natriuretic peptides have emerged as important candidates for the development of diagnostic tools in cardiovascular disease. Their increased concentrations have been found to be useful for ruling out disease of cardiac origin, as prognostic indicators, and in the follow-up of patients with heart failure. In order for natriuretic peptides to be efficient biomarkers, analytical problems in assay specificity and calibration need to be resolved. The aim of the present study was to elucidate circulating molecular components of N-terminal fragments of A- and B-type natriuretic peptides (NT-

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Chappell, Joel. "Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274543.

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Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs proliferate and display plasticity, or whether individual cells can switch to multiple phenotypes. To assess whether proliferation and plasticity in disease is a general characteristic of VSMCs or a feature of a subset of cells, multi-colour lineage labelling is used to demonstrate that VSMCs in injury-i

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Benmarhnia, Tarik. "Vulnérabilité à la chaleur dans le contexte des changements climatiques." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T003/document.

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Les changements climatiques constituent l’un des enjeux les plus importants en santé publique du XXIème siècle. En effet, une hausse des températures provoquera une hausse de la mortalité attribuable à la chaleur. En outre, certaines populations et territoires sont particulièrement vulnérables aux effets de la chaleur. Il est donc nécessaire de les identifier clairement ainsi que les impacts futurs pour orienter avec équité les politiques publiques aujourd’hui et à l’avenir. L’objectif de cette thèse est de documenter les facteurs de vulnérabilité à la chaleur dans le présent et les éléments p

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Di, Fusco Greta. "A Reliable Downscaling of ECG Signals for the Detection of T wave Heterogeneity Features." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016.

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In cardiovascular disease the definition and the detection of the ECG parameters related to repolarization dynamics in post MI patients is still a crucial unmet need. In addition, the use of a 3D sensor in the implantable medical devices would be a crucial mean in the assessment or prediction of Heart Failure status, but the inclusion of such feature is limited by hardware and firmware constraints. The aim of this thesis is the definition of a reliable surrogate of the 500 Hz ECG signal to reach the aforementioned objective. To evaluate the worsening of reliability due to sampling frequency

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Redon, Mathilde. "Biodiversité potentielle dans les forêts du Vercors : une approche hiérarchique pour la conservation des espaces forestiers." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00682041.

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Le déclin de la biodiversité lié à l'augmentation des pressions sur les ressources naturelles, fait l'objet d'un large consensus. Cette situation souligne un besoin urgent de développer des outils de diagnostic et de suivi de l'état de la biodiversité qui soient spatialisés, rapides à mettre en œuvre, peu coûteux et qui permettent de réaliser des expertises à l'échelle des territoires. Une des hypothèses centrales en écologie est qu'il existe des relations positives entre l'hétérogénéité spatiale mesurée dans la mosaïque paysagère et la richesse en espèces qui peut y cohabiter à différentes éc

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Comer, Neil Thomas. "Validation and heterogeneity investigation of the Canadian Land Surface Scheme (CLASS) for wetland landscapes." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38173.

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This thesis examines the development and validation of Canadian Land Surface Scheme (CLASS) for various wetland landscapes individually, along with an evaluation of modelled results over a heterogeneous surface with airborne observations. A further statistical analysis of the effects of land surface classification procedures over the study area and their influence on modelled results is performed. CLASS is tested over individual wetland types: bog, fen and marsh in a stand-alone (non-GCM coupled) mode. Atmospheric conditions are provided for the eight site locations from tower measured data, w

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Friedrich, Katja, and Nicole Mölders. "A numerical case study on the sensitivity of the water and energy fluxes to the heterogeneity of the distribution of land use." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213368.

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Numerical experiments assuming land-use distributions of different heterogeneity of wet and dry surfaces were performed on a cloudy day in spring with a calm wind to examine their influences on the domain-averaged fluxes as well as on the distribution of the fluxes within the domain. The results substantiate that, for ]arge heterogeneity, i.e., small patches, the distribution of the patches plays no role in the magnitude of the atmospheric fluxes. For !arger patches, however, the domain-averaged latent heat-fluxes depend appreciably on both the heterogeneity as well as on the fractional covera

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