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1

J, Hearse David, ed. The developing myocardium. Futura Pub. Co., 1991.

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2

Cell cycle regulation and differentiation in cardiovascular and neural systems. Springer, 2010.

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3

Watson, Andrea. Heat shock proteins in leukaemia cell differentiation and cell death. Aston University. Departmentof Pharmaceutical Sciences, 1990.

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4

Lesuisse, Christian. Role of the constitutive heat shock portein HSC70 during differentiation of haemopoieticcells. University of Manchester, 1994.

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5

B, Clark Edward, Markwald Roger R, and Takao Atsuyoshi, eds. Developmental mechanisms of heart disease. Futura Pub., 1995.

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6

De la Cruz, María Victoria. and Markwald Roger R, eds. Living morphogenesis of the heart. Birkhäuser, 1998.

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7

B, Clark Edward, and Takao Atsuyoshi, eds. Developmental cardiology: Morphogenesis and function. Futura Pub. Co., 1990.

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8

Takao, Atsuyoshi, and Edward Clark. Developmental Cardiology: Morphogenesis and Function. Futura Pub Co, 1990.

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9

Giordano, Antonio, and Umberto Galderisi. Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems. Springer, 2014.

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10

van den Hoff, Maurice J. B., and Antoon F. M. Moorman. From heart-forming region to ballooning chambers. Edited by Miguel Torres. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0006.

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This chapter describes the formation of the adult four-chambered heart from the precardiac mesodermal cells. The precardiac mesoderm develops into a linear heart tube by the process of folding. The subsequent increase in size of the heart by the addition of precursor cells derived from the first and second heart fields is discussed. For the sake of clarity, the chapter describes the addition of precursor cells to the inflow and outflow, separately. Next, the formation of the ventricular chambers with respect to ballooning and differentiation into a compact and trabecular layer is discussed. Fi
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11

(Editor), Vladimir Mironov, Charles Little (Editor), and Helen Sage (Editor), eds. Vascular Morphogenesis: In Vivo, in Vitro, in Mente. Birkhäuser Boston, 1998.

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12

1946-, Little Charles D., Mironov Vladimir 1954-, and Sage E. Helene 1946-, eds. Vascular morphogenesis: In vivo, in vitro, in mente. Birkhäuser, 1997.

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13

D’Andrea, Antonello, André La Gerche, and Christine Selton-Suty. Systemic disease and other conditions: athlete’s heart. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0055.

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The term ‘athlete’s heart’ refers to the structural, functional, and electrical adaptations that occur as a result of habitual exercise training. It is characterized by an increase of the internal chamber dimensions and wall thickness of both atria and ventricles. The athlete’s right ventricle also undergoes structural, functional, and electrical remodelling as a result of intense exercise training. Some research suggests that the haemodynamic stress of intense exercise is greater for the right heart and, as a result, right heart remodelling is slightly more profound when compared with the lef
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14

Crescenzi, Marco. Reactivation of the Cell Cycle in Terminally Differentiated Cells (Molecular Biology Intelligence Unit, 17). Springer, 2003.

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15

Marco, Crescenzi, ed. Reactivation of the cell cycle in terminally differentiated cells. Landes Bioscience, 2002.

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16

Baumgartner, Helmut, Stefan Orwat, Elif Sade, and Javier Bermejo. Heart valve disease (aortic valve disease): aortic stenosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0032.

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Echocardiography has become the gold standard for the assessment of patients with aortic stenosis (AS). It allows morphological assessment of the aortic valve and provides information on the aetiology of the disease. The quantification of AS includes primarily the measurement of transaortic jet velocities and gradients as well as the calculation of the valve area, thus combining flow-dependent and relatively flow-independent variables. Awareness of potential pitfalls is fundamental when assessing these variables. Haemodynamic consequences of AS on left ventricular (LV) size, wall thickness, an
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17

Rammah, Mayyasa, Francesca Rochais, and Robert G. Kelly. Incorporation of myocardial progenitors at the arterial pole of the heart. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0007.

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The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). It is formed by progressive addition of myocardium from epithelial progenitor cells in the second heart field (SHF). SHF cells contribute successively to the right ventricle and proximal and distal outflow tract myocardial walls which, after neural crest influx and cardiac septation, give rise to myocardium at the base of the aorta and pulmonary trunk. SHF cells are characterized by continued proliferation and differentiation delay controlled by an array of transcriptional regulators and
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18

Banerjee, Ashis, and Clara Oliver. Cardiac emergencies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198786870.003.0009.

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Chest pain is a common presenting complaint for patients in the emergency department. This chapter focuses on the management and recent changes to non-ST-segment elevation myocardial infarction (NSTEMI) and STEMI pathways, in keeping with national guidance. Arrhythmia management including atrial fibrillation as well as the use of scoring systems as the CHADVASC score also commonly appears in the short-answer question (SAQ) paper, which is covered in this chapter in line with current NICE guidance. In addition, there is also a section on the diagnosis and differentiation on managing a patient w
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19

Campione, Marina, Amelia Aranega, and Diego Franco. Cardiac looping and laterality. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0014.

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Dextral looping is a complex process which progresses concomitantly with cardiac chamber differentiation and ultimately leads to the final alignment of the cardiac regions. Generation of cardiac asymmetry is crucial to ensure the proper form and consequent function of the heart and thus is a highly regulated process. Molecular signals originate long before morphological asymmetry and therefore can direct it; a complex regulatory network has been characterized which invariably converges on the Tgf-β‎ signalling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. W
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20

Dyer, Laura A., and Margaret L. Kirby. The role of the neural crest in cardiac development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0019.

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The cardiac neural crest (CNC) plays pivotal roles in numerous steps of cardiac development. Every aspect of the CNC cell’s lifespan is highly orchestrated, from its induction in the dorsal neural tube to its migration to its differentiation at its final destination. During migration, CNC cells are affected by their environment and simultaneously modulate the extra-cellular milieu through which they migrate. In the pharyngeal arches, CNC cells repattern the originally symmetrical arch arteries, producing the great arteries. Because the cardiac neural crest is essential for many aspects of hear
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21

Margulis, Elizabeth Hellmuth. Expectation, Musical Topics, and the Problem of Affective Differentiation. Edited by Danuta Mirka. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199841578.013.0025.

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Since Leonard Meyer (1956), music theorists have looked to expectation as a primary generator of musical affect. Yet, expectation and its complement—surprise—do not explain affective differentiation of the experience of listening to music. This study looks to a different tradition in music theory—that of musical topics—for a possible explanation. Listeners heard excerpts representing one of four musical topics in a normative and surprising version, where a general pause had been inserted before the cadence. Listeners continuously rated the excerpts as they progressed along one of four differen
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22

Cahill, Thomas J., and Paul R. Riley. Epicardial and coronary vascular development. Edited by Miguel Torres. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0009.

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The coronary circulation is essential for human life. In embryonic development, abnormal formation of the coronary vasculature can cause death in utero or after birth. In adulthood, atherosclerosis of the coronary arteries is the commonest cause of death worldwide. The last decade has witnessed significant strides forward in our understanding of coronary development. Multiple sources of coronary endothelial cells have been identified using genetic tools for fate mapping. The epicardium, the outermost layer of the developing heart, has emerged as both a source of cell progenitors and key signal
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23

Fulcoli, F. Gabriella, and Antonio Baldini. Transcriptional regulation of early cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0006.

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The two major cardiac cell lineages of the vertebrate heart, the first and second cardiac fields (FHF and SHF), have different developmental ontogeny and thus different transcription programs. Most remarkably, the fate of cardiac progenitors (CPs) of the FHF is restricted to cardiomyocyte differentiation. In contrast, SHF CPs, which are specified independently, are maintained in a multipotent state for a relatively longer developmental time and can differentiate into multiple cell types. The identity of the transcription factors and regulatory elements involved in progenitor cell programming a
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24

Kang, Susey H. Characterization of gene expression profiles during differentiation, lipopolysaccharide stimulation, and heat shock repression in human U937 monocyte cells. 2004.

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25

Crouch, Robert, Alan Charters, Mary Dawood, and Paula Bennett, eds. Cardiovascular emergencies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688869.003.0008.

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Chest pain is a common presentation in emergency and urgent care settings. Differentiating between conditions that require immediate intervention and those that are more benign can be difficult. Patients with cardiovascular problems have a wide range of needs; some can be managed by ambulatory care units, whereas others require lifesaving resuscitation. This chapter covers the nursing assessment and investigations of patients presenting with problems related to the cardiovascular system. It also covers neonatal, paediatric, and adult resuscitation, including post-resuscitation care. The nursin
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26

Thompson, John D. Plant Evolution in the Mediterranean. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198835141.001.0001.

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Plant Evolution in the Mediterranean: Insights for conservation brings together a diverse literature on the Mediterranean flora in a detailed but synthetic account of plant evolutionary ecology. The central themes of ecological dynamics and evolutionary differentiation are developed at two spatial scales: habitat variation across the landscape and biogeographic processes across the Mediterranean. The history of the Mediterranean region is at the heart of this account and is described within a triptych that links geological and climatic history to the advent and history of human activities. The
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27

Douglas, Kenneth. Bioprinting. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.001.0001.

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Abstract: This book describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. Readers will lear
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28

Karatasakis, G., and G. D. Athanassopoulos. Cardiomyopathies. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0019.

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Echocardiography is a key diagnostic method in the management of patients with cardiomyopathies.The main echocardiographic findings of hypertrophic cardiomyopathy are asymmetric hypertrophy of the septum, increased echogenicity of the myocardium, systolic anterior motion, turbulent left ventricular (LV) outflow tract blood flow, intracavitary gradient of dynamic nature, mid-systolic closure of the aortic valve and mitral regurgitation. The degree of hypertrophy and the magnitude of the obstruction have prognostic meaning. Echocardiography plays a fundamental role not only in diagnostic process
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29

Bean, Hamilton. United States Intelligence Cultures. Oxford University Press, 2018. http://dx.doi.org/10.1093/acrefore/9780190846626.013.357.

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Organizational culture refers to the constellation of values, beliefs, identities, and artifacts that both shape and emerge from the interactions among the formal members of the US intelligence community. It is useful for understanding interagency cooperation and information sharing, institutional reform, leadership, intelligence failure, intelligence analysis, decision making, and intelligence theory. Organizational culture is also important in understanding the dynamics of US intelligence. There are four “levels” of, or “perspectives” on, organizational culture: vernacular and mundane organi
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30

Lameire, Norbert, Raymond Vanholder, and Wim Van Biesen. Clinical approach to the patient with acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0222_update_001.

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The prognosis of acute kidney injury (AKI) depends on early diagnosis and therapy. A multitude of causes are classified according to their origin as prerenal, intrinsic (intrarenal), and post-renal.Prerenal AKI means a loss of renal function despite intact nephrons, for example, because of volume depletion and/or hypotension.There is a broad spectrum of intrinsic causes of AKI including acute tubular necrosis (ATN), interstitial nephritis, glomerulonephritis, and vasculitis. Evaluation includes careful review of the patient’s history, physical examination, urinalysis, selected urine chemistrie
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