Journal articles: 'Heart disease in the newborn'

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Taksande, Amar, and Sachin Dhamke. "Critical Congenital Heart Disease in Newborns." Pediatric Education and Research 5, no. 2 (2017): 87–95. http://dx.doi.org/10.21088/per.2321.1644.5217.17.

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&NA;. "Missed Heart Disease in the Newborn." Advances in Neonatal Care 9, no. 1 (February 2009): 4. http://dx.doi.org/10.1097/01.anc.0000346085.74744.13.

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El Idrissi Slitine, Nadia, Fatiha Bennaoui, Craig A. Sable, Gerard R. Martin, Lisa A. Hom, Amal Fadel, Soufiane Moussaoui, et al. "Pulse Oximetry and Congenital Heart Disease Screening: Results of the First Pilot Study in Morocco." International Journal of Neonatal Screening 6, no. 3 (June 30, 2020): 53. http://dx.doi.org/10.3390/ijns6030053.

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Congenital heart disease (CHD) is the most common congenital malformation. Diagnosis of critical congenital heart disease (CCHD), the most severe type of congenital heart disease, in a newborn may be difficult. The addition of CCHD screening, using pulse oximetry, to clinical assessment significantly improves the rate of detection. We conducted a pilot study in Morocco on screening neonates for critical congenital heart disease. This study was conducted in the maternity ward of Mohammed VI University Hospital of Marrakesh, Morocco, and included asymptomatic newborns delivered between March 2019 and January 2020. The screening of CCHD was performed by pulse oximetry measuring the pre- and post-ductal saturation. Screening was performed on 8013/10,451 (76.7%) asymptomatic newborns. According to the algorithm, 7998 cases passed the screening test (99.82%), including one inconclusive test that was repeated an hour later and was normal. Fifteen newborns failed the screening test (0.18%): five CCHD, five false positives, and five CHD but non-critical. One false negative case was diagnosed at 2 months of age. Our results encourage us to strengthen screening for CCHD by adding pulse oximetry to the routine newborn screening panel.

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WENDLING, PATRICE. "HHS Calls for Newborn Heart Disease Screening." Pediatric News 45, no. 11 (November 2011): 25. http://dx.doi.org/10.1016/s0031-398x(11)70299-5.

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Al-Ammouri, Iyad, Fares Ayoub, and Rima Dababneh. "Is pre-discharge echocardiography indicated for asymptomatic neonates with a heart murmur? A retrospective analysis." Cardiology in the Young 26, no. 6 (September 10, 2015): 1056–59. http://dx.doi.org/10.1017/s1047951115001705.

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AbstractObjectiveThe purpose of this study was to determine whether a murmur detected on routine pre-discharge examination of asymptomatic newborn children in the first 48 hours of life warrants further investigation with echocardiography.MethodsWe conducted a retrospective review of all echocardiography studies of neonates born at Jordan University Hospital between August, 2007 and June, 2014. Findings on physical examination as well as the indication of the echocardiographic studies were reviewed. We included asymptomatic neonates for whom echocardiographic studies were carried out due to the sole indication of a heart murmur on routine pre-discharge neonatal physical examination.ResultsOf 309 asymptomatic newborns with murmurs on pre-discharge examination, echocardiography revealed 68 (22%) cases of CHD, with 18 (6%) designated as significant heart disease with anticipated intervention during infancy or childhood. The most common abnormality was ventricular septal defect occurring in 36 cases. Critical heart diseases detected included hypoplastic left heart syndrome in two and aortic valve stenosis in four newborns.ConclusionsAlthough most asymptomatic neonates with heart murmurs have normal hearts, a small percentage may have significant heart disease. The decision to refer an asymptomatic newborn with a murmur for echocardiography before discharge from the hospital remains controversial and must be supported by other evidence such as murmur characteristics and local trends in parental compliance with follow-up well-baby visits.

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Seignior, Helen Louise. "What is the significance of hearing a heart murmur during the newborn physical examination?" British Journal of Midwifery 29, no. 3 (March 2, 2021): 158–70. http://dx.doi.org/10.12968/bjom.2021.29.3.158.

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Background Newborn screening for congenital heart disease (CHD) forms part of the newborn physical examination (NPE) in the UK. However, research has shown that up to 50% of cases of CHD can be missed by this examination. The purpose of this literature review is to investigate the significance of hearing an asymptomatic heart murmur at the NPE in relation to the presence of CHD. Methodology A critical literature review was conducted to answer the research question. The findings were discussed using a narrative synthesis approach. Findings There was considerable heterogeneity of results. The prevalence of murmur in newborns ranged between 0.6%–10.7%. Between 13%–67% of those newborns had some form of CHD, although many had clinically insignificant lesions. Between 2%–9% of newborns with murmurs had a form of critical CHD (CCHD). The ability to discern whether a heart murmur relates to pathology or not improves with experience. No single optimal timing for the NPE was identified. Pulse oximetry was shown to increase sensitivity of screening for CCHD. Conclusion There is a significant increase in the prevalence of CHD when a newborn has a heart murmur, hence referral for diagnostic echocardiography is required when a heart murmur is identified. Pulse oximetry is an important adjunct to newborn screening for CCHD. Some newborns affected by CCHD will not present with murmur at the NPE. Therefore, those caring for newborns during the early days must know the signs and symptoms of CHD so that appropriate medical assistance can be sought.

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Sahota, Ravi, Navpreet Kaur, Gurpal Singh, Veena Joshi, Bharti Gahtori, Divya Mehrotra, and Nisha Upadhyay. "Study the universal critical congenital heart disease screening in a peripheral area of Uttarakhand, India." International Journal of Contemporary Pediatrics 7, no. 9 (August 25, 2020): 1849. http://dx.doi.org/10.18203/2349-3291.ijcp20203641.

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Background: Congenital heart disease (CHD) is the most frequently occurring congenital disorder, responsible for 28% of all congenital birth defects. The birth prevalence of CHD is reported to be 8-12/1000 live births. Considering a rate of 9/1000, about 1.35 million babies are born with CHD each year globally. Objective of research work to study the prevalence of CHD among newborn and its types.Methods: This cross-sectional study was carried among 34 cases of CHD/5126 newborn screened at 4 birthing places in Kashipur a small town in Uttrakhand at pediatrics department of Sahota Super-specialty hospital, Kashipur, Uttarakhand. Screening program between 22 August 2014, and March 30, 2019. All newborns, including preterm babies, delivered in these facilities were eligible for inclusion in this study.Results: Present study found the prevalence of CHD was 0.7 per 1000 children (34/5126). Around 26.5% participants have cyanotic CHD and 73.5% have acynotic CHD. Almost 44%, 28%, 20%, 4% and 4% participants of acynotic congenital heart diseases have VSD, ASD, PDA, AVSD and valvular PS respectively and 55.6%, 22.2%, 11.1% and 11.1% participants of cynotic congenital heart diseases have TOF, DORV/VSD, dTGA/VSD and tricuspid atresia respectively.Conclusions: Screening for congenital heart disease should be included as a part of newborn assessment as it is a common congenital problem. Early identification influences outcome. Barriers in implementation of the screening programmes in resource limited setting is a challenging feature. This study can provide observed data that can help in policy making in the health sector.

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Nartsissova, G. P., O. A. Lenko, Yu S. Sinelnikov, and I. I. Volkova. "Staged and consistent perinatal diagnostics of congenital heart disease." Patologiya krovoobrashcheniya i kardiokhirurgiya 17, no. 2 (October 10, 2015): 75. http://dx.doi.org/10.21688/1681-3472-2013-4-75-80.

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The principles of organization of perinatal diagnostics of congenital heart disease (CHD) carried out by the advisory group of the cardiac center are presented. 1 601 pregnant women at the age from 18 to 40 years and 20 to 38-39 weeks of gestation were examined. 657 (41%) of them had risk factors of CHD development, while 336 (21%) were diagnosed with congenital heart disease. Only 19.1% of pregnant women with CHD fetus had risk factors, with no such relation observed in other women. Surgical repair was performed in 56.4% of cases during a newborn period. A three-stage system of perinatal diagnostics of congenital heart disease performed by the cardiac center's experts over prenatal and neonatal periods allows providing consistency and efficiency of rendering assistance to newborns with congenital heart disease.

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Belanger, Michael, Luke Tan, and Carin Wittnich. "Does young age really put the heart at risk?" Canadian Journal of Physiology and Pharmacology 95, no. 10 (October 2017): 1177–82. http://dx.doi.org/10.1139/cjpp-2017-0072.

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Despite significant advances in the management and treatment of heart disease in children, there continue to be patients who have worse outcomes than might be expected. A number of risk factors that could be responsible have been identified. Evidence-based findings will be reviewed, including whether young age and (or) reduced body weight exacerbate these responses. For example, newborn children undergoing congenital cardiac surgery are known to have worse outcomes than older children. Evidence exists that newborn hearts do not tolerate ischemia as well as adult hearts, developing irreversible injury sooner and exhibiting at-risk metabolic profiles. As well, in response to the administration of heparin, elevations in free fatty acids occur during congenital heart surgery in children, which can have detrimental effects on the heart. Furthermore, myocardial energetic state has also been suggested to impact outcomes. Unfavourable energetic profiles were correlated to lower body weights in the same age healthy newborn piglet model. Newborn children suffering from congenital heart disease, with lower body weights, also had lower myocardial energetic state and this correlated with longer postoperative ventilatory support as well as a trend to longer intensive care unit stay. These findings imply that unfavourable myocardial metabolic profiles could contribute to postoperative complications.

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Badawi, Deborah, Johnna Watson, Steven Maschke, and Lawrence Reid. "First-Year Outcomes of Critical Congenital Heart Disease Screening in Maryland." Global Pediatric Health 6 (January 2019): 2333794X1986822. http://dx.doi.org/10.1177/2333794x19868226.

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Objectives. Newborn screening for critical congenital heart disease (CCHD) was added to the Recommended Uniform Screening Panel in 2011, and states have been gradually adding pulse oximetry as point-of-care screening to panels. Few data are available on the effectiveness of pulse oximetry as a mandated screening. This study describes outcomes of the first year of screening in Maryland. Methods. A web-based data collection tool for screening results and outcomes, eScreener Plus, was utilized. Data collected from the start of screening from September 1, 2012, to December 31, 2013, were analyzed. Well-baby nursery data were evaluated separately from neonatal intensive care unit (NICU) data to determine whether setting influenced effectiveness. Results. In the first 15 months of newborn screening for CCHD in Maryland, 4 asymptomatic infants were diagnosed with a critical cardiac condition by newborn screening. Eleven infants passed but were later identified with a primary or secondary target condition. Seventy-one percent of infants with CCHD were identified prenatally or by clinical signs and symptoms. Pulse oximetry screening for CCHD had a specificity of more than 99% in both the well-baby nursery and the NICU. Sensitivity in the well-baby nursery was 10% and 60% in the NICU. Conclusion. Further investigation and interpretation of specific protocols that were used and outcomes of screening is needed for continued refinement of the well-baby algorithm and NICU protocol development. Pulse oximetry screening in newborns provides valuable clinical information, but many infants with CCHD are still not identified with current protocols.

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Fran Hazinski, Mary. "Congenital Heart Disease in the Neonate." Neonatal Network 21, no. 3 (April 2002): 31–42. http://dx.doi.org/10.1891/0730-0832.21.3.31.

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Part I: Epidemiology, Cardiac Development, and Fetal CirculationCONGENITAL HEART DISEASE IS PRESENT IN ROUGHLY eight to ten out of every thousand newborn infants.1 However, within the neonatal intensive care unit, the incidence of congenital heart disease is much higher than this, because low birth weight or small-for-date infants are more likely to have congenital heart disease than normal infants.2

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Taksande, Amar, and Patel Zeeshan Jameel. "Critical Congenital Heart Disease in Neonates: A Review Article." Current Pediatric Reviews 17, no. 2 (August 23, 2021): 120–26. http://dx.doi.org/10.2174/1573396317666210219162515.

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Critical congenital heart defects (CCHDs) are serious malformations that remain to be an important cause of neonatal mortality and morbidity. The clinical presentations of CCHD are shock, cyanosis, or respiratory distress, which may be similar to that of other neonatal conditions. Failure to diagnose these conditions early on after birth may result in acute cardiovascular collapse and death. Screening with routine pulse oximetry is efficient in distinguishing newborns with CCHD and other hypoxemic illnesses, which may otherwise be potentially life-threatening. If the cardiovascular system cannot be observed by echocardiography, then treatment with continuous prostaglandin-E1(PGE1) infusion should be started in any newborn whose condition deteriorates in the first few days of life. This review aims to provide a concise summary of the presentation and management of various CCHDs and to emphasize the role of timely diagnosis in the management.

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Seignior, Helen. "Congenital heart disease: issues with screening at the newborn physical examination." British Journal of Midwifery 27, no. 11 (November 2, 2019): 682–87. http://dx.doi.org/10.12968/bjom.2019.27.11.682.

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Congenital heart disease (CHD) is a significant cause of infant death in the developed world. For this reason, screening for CHD forms part of the newborn physical examination (NPE) that occurs within 72 hours of birth. This article reviews the challenges faced by the examiner in the detection of CHD in the newborn. This includes relevant anatomy and physiology of the newborn circulation and the presentation of heart murmurs. The usefulness of additional screening tools is also discussed. Four-limb blood pressure (BP) is found to be unhelpful as a screening tool, whereas the use of pulse oximetry is supported by research evidence.

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Halim, Lidia, Muhammad Ali, and Tiangsa Sembiring. "Association between oxygen saturation and critical congenital heart disease in newborns." Paediatrica Indonesiana 58, no. 2 (April 27, 2018): 90–4. http://dx.doi.org/10.14238/pi58.2.2018.90-4.

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Background Critical congenital heart disease (CCHD) is relatively common, with a prevalence of 6-8 in every 1,000 live births. This congenital anomaly is a newborn condition that would be ideally suited for a screening program, if simple and reliable methods were available. Pulse oximetry (PO) has been proposed as a screening method to detect CCHD. Objective To assess for a possible association between decreased oxygen saturation and CCHD in newborns. Methods We conducted a cross-sectional study from March 2014 to February 2015 in several hospitals in North Sumatra. Healthy, full term and post-term newborns aged 2 to 72 hours underwent pulse oximetry measurements on the right hand and one of the lower extremities. If oxygen saturation (SpO2) was ≤ 95%, the measurement was repeated 2 more times. Subjects also underwent echocardiography. Results A total of 386 newborns underwent SpO2 measurements: 377 newborns had SpO2 > 95% and 9 newborns had SpO2 ≤ 95%. Of the infants with SpO2 > 95%, 297 were excluded because their parents refused echocardiography examination. Thus, 80 newborns with SpO2 > 95% and 9 newborns with SpO2 ≤ 95% underwent echocardiography. Echocardiography revealed that 5 of 9 newborns with SpO2 ≤ 95% suffered from Tetralogy of Fallot (ToF) (3 subjects) and transposition of the great arteries (TGA) (2 subjects). One infant with SpO2 > 95% had ventricular septal defect (VSD), as detected by echocardiography. Oxygen saturation ≤ 95% had significant association with CCHD (P<0.001). Conclusion Decreased oxygen saturation has a significant association with critical congenital heart disease in newborns.

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Morrow, W. R. "Early Newborn Discharge and Death from Congenital Heart Disease." AAP Grand Rounds 2, no. 6 (December 1, 1999): 61–62. http://dx.doi.org/10.1542/gr.2-6-61.

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Östman-Smith, Ingegerd, and Anne de-Wahl Granelli. "Screening for congenital heart disease with newborn pulse oximetry." Lancet 379, no. 9813 (January 2012): 309–10. http://dx.doi.org/10.1016/s0140-6736(12)60135-4.

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Macfarlane, Peter, and Rupa Talekar. "Screening for congenital heart disease with newborn pulse oximetry." Lancet 379, no. 9813 (January 2012): 310. http://dx.doi.org/10.1016/s0140-6736(12)60136-6.

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Nirantharakumar, Krishnarajah. "Screening for congenital heart disease with newborn pulse oximetry." Lancet 379, no. 9813 (January 2012): 310–11. http://dx.doi.org/10.1016/s0140-6736(12)60137-8.

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Cao, L., and Y. Ren. "OP15.03: Prenatal and newborn screening for congenital heart disease." Ultrasound in Obstetrics & Gynecology 54, S1 (September 30, 2019): 134. http://dx.doi.org/10.1002/uog.20795.

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Yun, Sin Weon. "Congenital heart disease in the newborn requiring early intervention." Korean Journal of Pediatrics 54, no. 5 (2011): 183. http://dx.doi.org/10.3345/kjp.2011.54.5.183.

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McClain, Monica R., John S. Hokanson, Regina Grazel, Kim Van Naarden Braun, Lorraine F. Garg, Michelle R. Morris, Kathleen Moline, et al. "Critical Congenital Heart Disease Newborn Screening Implementation: Lessons Learned." Maternal and Child Health Journal 21, no. 6 (January 16, 2017): 1240–49. http://dx.doi.org/10.1007/s10995-017-2273-4.

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Hamilçıkan, Şahin, and Emrah Can. "Critical congenital heart disease screening with a pulse oximetry in neonates." Journal of Perinatal Medicine 46, no. 2 (February 23, 2018): 203–7. http://dx.doi.org/10.1515/jpm-2017-0006.

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AbstractObjective:To compare the results of pulse oximetry screening for critical congenital heart disease (CCHD) in newborn infants performed at <24 h and >24 h following.Method:Measurements were taken for each group at <24 h and >24 h following birth. Echocardiography was performed if the SpO2 readings remained abnormal results.Results:A total of 4518 newborns were included in this prospective descriptive study. Of these, 2484 (60.3%) were delivered vaginally and 1685 (39.7%) by cesarean section. Median time points of the screening were 25.4 (25.3–25.5) vs. 17.3 (12.2–22.4) hours after birth. In 4109 infants screened 24 h after birth, the mean pre- and postductal oxygen saturations (SpO2) were 96.5±1.99 and 97.7±1.98, while 127 infants screened within 24 h of mean preductal and postductal SpO2 were 91.33±2.64 and 94.0±4.44. No CCHD was detected during the study period. Pulse oximetry screening was false positive for CCHD in 9 of 4109 infants (0.02%); of these, six infants were referred to pediatric cardiology and three cases were diagnosed as other significant, non-cardiac pathology. There were two cases with AVSD (atrioventricular septal defect, three cases with ventricular septal defect (VSD), and one case with patent ductus arteriosus (PDA).Conclusions:Saturation values are different between <24-h and >24-h neonates in pulse oximetry screening. The screening in this study identified infants with other important pathologies, this forms an added value as an assessment tool for newborn infants.

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Sawada, Takaaki, Jun Kido, and Kimitoshi Nakamura. "Newborn Screening for Pompe Disease." International Journal of Neonatal Screening 6, no. 2 (April 5, 2020): 31. http://dx.doi.org/10.3390/ijns6020031.

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Glycogen storage disease type II (also known as Pompe disease (PD)) is an autosomal recessive disorder caused by defects in α-glucosidase (AαGlu), resulting in lysosomal glycogen accumulation in skeletal and heart muscles. Accumulation and tissue damage rates depend on residual enzyme activity. Enzyme replacement therapy (ERT) should be started before symptoms are apparent in order to achieve optimal outcomes. Early initiation of ERT in infantile-onset PD improves survival, reduces the need for ventilation, results in earlier independent walking, and enhances patient quality of life. Newborn screening (NBS) is the optimal approach for early diagnosis and treatment of PD. In NBS for PD, measurement of AαGlu enzyme activity in dried blood spots (DBSs) is conducted using fluorometry, tandem mass spectrometry, or digital microfluidic fluorometry. The presence of pseudodeficiency alleles, which are frequent in Asian populations, interferes with NBS for PD, and current NBS systems cannot discriminate between pseudodeficiency and cases with PD or potential PD. The combination of GAA gene analysis with NBS is essential for definitive diagnoses of PD. In this review, we introduce our experiences and discuss NBS programs for PD implemented in various countries.

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Nair, Anishkumar, Gopalan Nair Rajesh, and Chakanalil Govindan Sajeev. "Functional tricuspid stenosis: a rare presentation of suspected rhabdomyoma as congenital cyanotic heart disease." Cardiology in the Young 27, no. 4 (January 12, 2017): 808–11. http://dx.doi.org/10.1017/s1047951116002110.

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AbstractCardiac tumours in newborns are often asymptomatic and can be sporadically detected on routine screening unless they result in intractable arrhythmias or haemodynamically significant obstructions causing heart failure. Their presentation as a cause of congenital cyanosis is never anticipated. We report a rare case of a newborn presenting with congenital cyanosis consequent to suspected cardiac rhabdomyoma causing tricuspid inflow obstruction. Our experience with this patient with two large cardiac masses illustrates the significance of its inclusion in the differential diagnosis of perinatal cyanosis, as early detection and surgical management might be the only lifesaving options, if performed well in time.

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Gong, Alice, Judith Livingston, Liza Creel, Elena Ocampo, Tiffany McKee-Garrett, and Charleta Guillory. "Texas Pulse Oximetry Project: A Multicenter Educational and Quality Improvement Project for Implementation of Critical Congenital Heart Disease Screening Using Pulse Oximetry." American Journal of Perinatology 34, no. 09 (March 6, 2017): 856–60. http://dx.doi.org/10.1055/s-0037-1599214.

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Objective Critical congenital heart disease (CCHD) is a leading cause of death in infants. Newborn screening (NBS) by pulse oximetry allows early identification of CCHD in asymptomatic newborns. To improve readiness of hospital neonatal birthing facilities for mandatory screening in Texas, an educational and quality improvement (QI) project was piloted to identify an implementation strategy for CCHD NBS in a range of birthing hospitals. Study Design Thirteen Texas hospitals implemented standardized CCHD screening by pulse oximetry. An educational program was devised and a tool kit was created to facilitate education and implementation. Newborn nursery nurses' knowledge was assessed using a pre- and posttest instrument. Results The nurses' knowledge assessment improved from 71 to 92.5% (p < 0.0001). Of 11,322 asymptomatic newborns screened after 24 hours of age, 11 had a positive screen, with 1 confirmed case of CCHD. Pulse oximetry CCHD NBS had sensitivity of 100%, specificity of 99.91%, false-positive rate of 0.088%, positive predictive value of 9.09%, and negative predictive value of 100%. Conclusion Our educational program, including a tool kit, QI processes, and standardized pulse oximetry CCHD NBS, is applicable for a range of hospital birthing facilities and may facilitate wide-scale implementation, thereby improving newborn health.

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Melekoglu, Asli Nuriye, and Osman Baspinar. "Transcatheter cardiac interventions in neonates with congenital heart disease: A single centre experience." Journal of International Medical Research 47, no. 2 (October 30, 2018): 615–25. http://dx.doi.org/10.1177/0300060518806111.

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Objective Percutaneous cardiac catheterization has been used as a diagnostic tool and as a therapeutic option in neonates with congenital heart disease (CHD). This study aimed to evaluate the procedural and short-term follow-up data of newborns who underwent cardiac catheterization procedures. Methods This retrospective study reviewed demographic, diagnostic and clinical data from the medical records of newborns who underwent percutaneous transcatheter interventions to treat CHD. Results Forty-six newborns were included in the study. The median gestational week and weight were 35.0 weeks and 2723 g, respectively. The median time to the procedure was 7.6 days. Aortic and pulmonary balloon valvuloplasty, ductal stenting, atrial balloon/blade septostomy and coronary fistula embolization procedures were used. The overall success rate was 73.9% (34 of 46 patients) with a complication rate of 28.3% (13 of 46 patients). Eleven patients (23.9%) underwent reinterventions after initial catheterization. Five patients (10.9%) died in the first 48 h after their procedures. Conclusions Interventional cardiological procedures applied during the neonatal period provide alternative life-saving methods to surgery, especially in developing countries where surgical outcomes are poor and newborn mortality rates are high.

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Akhmedova, Irina, Gulzada Imanalieva, Damirbek Abibillaev, and Taalaibek Kudaiberdiev. "Primary detection of congenital heart diseases in the Kyrgyz Republic." Heart, Vessels and Transplantation 2, Issue 2 (June 3, 2018): 56. http://dx.doi.org/10.24969/hvt.2018.66.

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Objective: The aim of this paper is to understand the structure of congenital heart diseases (CHD) and the age of the first diagnosis in a population referred to specialized cardiac surgery center from different regions of Kyrgyz Republic. Methods: In 2017, 7213 people of different ages, from Kyrgyz Republic were examined by using transthoracic echocardiogram at cardiac surgery center aimed to detection of congenital heart disease Results: In total, 478 new patients with primary diagnosis of CHD were identified; 413 (86%) patients had a delayed diagnosis. The total detectability was 6.75%. The structure of congenital heart disease has a large difference depending on the age group. The proportion of complex heart defects predominates in newborn children and significantly decreases with age. Conclusion: A study of the prevalence and structure of heart defects in the country will help to find the right decision in planned care for patients with CHD, in cases of limited resources. Keywords: newborn, congenital heart defects, diagnostics, prevalence, echocardiography

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Barlow, R., C. Holloway, and W. Lutin. "412 SCREENING FOR CONGENITAL HEART DISEASE IN THE NEWBORN NURSERY." Journal of Investigative Medicine 53, no. 1 (January 1, 2005): S326.5—S326. http://dx.doi.org/10.2310/6650.2005.00006.411.

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Gievers, L., D. H. Kim, and A. M. Garcia. "Newborn With Hypotonia, Congenital Heart Disease, Hypoglycemia, and Enlarged Corneas." NeoReviews 15, no. 11 (October 31, 2014): e510-e513. http://dx.doi.org/10.1542/neo.15-11-e510.

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Studer, Matthew A., Ashley E. Smith, Michael B. Lustik, and Michael R. Carr. "Newborn Pulse Oximetry Screening to Detect Critical Congenital Heart Disease." Journal of Pediatrics 164, no. 3 (March 2014): 505–9. http://dx.doi.org/10.1016/j.jpeds.2013.10.065.

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Ichihashi, Kou, Akira Matsui, Masayoshi Yanagisawa, and Shigeki Yamada. "Hepatic Cell Necrosis with Congenital Heart Disease in the Newborn." Pediatrics International 33, no. 1 (February 1991): 87–92. http://dx.doi.org/10.1111/j.1442-200x.1991.tb01525.x.

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Hellström-Westas, L., K. Hanséus, P. Jögi, N. R. Lundström, and N. Svenningsen. "Long-Distance Transports of Newborn Infants with Congenital Heart Disease." Pediatric Cardiology 22, no. 5 (September 2001): 380–84. http://dx.doi.org/10.1007/s002460010254.

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Magalhaes, Simone Silveira, Maria Veraci Oliveira Queiroz, and Edna Maria Camelo Chaves. "Cuidados da enfermagem neonatal ao bebê com cardiopatia congênita: revisão integrativa." Online Brazilian Journal of Nursing 15, no. 4 (December 30, 2016): 724. http://dx.doi.org/10.17665/1676-4285.20165415.

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Aim: to search for available evidence in the literature about nursing care for newborns with congenital heart disease in neonatal units. Method: An integrative review of the literature performed between July and August 2015, based on research in LILACS, PubMed and CINAHL databases. Result: Nine articles were identified according to established criteria. The information was analyzed and synthesized in three thematic categories: Detecting congenital heart disease; Providing care for the neonate in the intensive care unit; Family and the care measures to the newborn. Discussion: Neonatal screening for critical heart defects by pulse oximetry and nursing care at bedside surgeries were the main health care measures of nurses for infants with neonatal heart disease. Conclusion: There is a need for more professional involvement in the provision of care for these children in order to provide evidence-based clinical practice, and there are gaps in nurses' knowledge production that demonstrate this reality.

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Aranguren Bello, Hernán Camilo, Dario Londoño Trujillo, Gloria Amparo Troncoso Moreno, Maria Teresa Dominguez Torres, Alejandra Taborda Restrepo, Alejandra Fonseca, Nestor Sandoval Reyes, Cindy Lorena Chamorro, and Rodolfo José Dennis Verano. "Oximetry and neonatal examination for the detection of critical congenital heart disease: a systematic review and meta-analysis." F1000Research 8 (March 1, 2019): 242. http://dx.doi.org/10.12688/f1000research.17989.1.

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Background: Undiagnosed congenital heart disease in the prenatal stage can occur in approximately 5 to 15 out of 1000 live births; more than a quarter of these will have critical congenital heart disease (CCHD). Late postnatal diagnosis is associated with a worse prognosis during childhood, and there is evidence that a standardized measurement of oxygen saturation in the newborn by cutaneous oximetry is an optimal method for the detection of CCHD. We conducted a systematic review of the literature and meta-analysis comparing the operational characteristics of oximetry and physical examination for the detection of CCHD. Methods: A systematic review of the literature was conducted on the following databases including published studies between 2002 and 2017, with no language restrictions: Pubmed, Science Direct, Ovid, Scopus and EBSCO, with the following keywords: oximetry screening, critical congenital heart disease, newborn OR oximetry screening heart defects, congenital, specificity, sensitivity, physical examination. Results: A total of 419 articles were found, from which 69 were selected based on their titles and abstracts. After quality assessment, five articles were chosen for extraction of data according to inclusion criteria; data were analyzed on a sample of 404,735 newborns in the five included studies. The following values were found, corresponding to the operational characteristics of oximetry in combination with the physical examination: sensitivity: 0.92 (CI 95%, 0.87-0.95), specificity: 0.98 (CI 95%, 0.89-1.00), for physical examination alone sensitivity: 0.53 (CI 95%, 0.28-0.78) and specificity: 0.99 (CI 95%, 0.97-1.00). Conclusions: Evidence found in different articles suggests that pulse oximetry in addition to neonatal physical examination presents optimal operative characteristics that make it an adequate screening test for detection of CCHD in newborns, above all this is essential in low and middle-income settings where technology medical support is not entirely available.

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McNamara, Dan G. "What the Pediatrician should know about Congenital Heart Disease." Paediatrica Indonesiana 15, no. 1-2 (May 29, 2017): 55. http://dx.doi.org/10.14238/pi15.1-2.1975.55-68.

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Initial recognition of congenital heart disease in the neonate as well as decisions for referral to a cardiac center for subsequent management are usually the responsibility of the pediatrician. While the malformations of the heart sometimes present obvious mamifestions in the newborn, the early diagnosis is more often elusive and the type and severity of cardiac dysfunction can be obscure, especially when only traditional methods of clinical evaluation are used.

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Delaney, Meghan, and Dana C. Matthews. "Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn." Hematology 2015, no. 1 (December 5, 2015): 146–51. http://dx.doi.org/10.1182/asheducation-2015.1.146.

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AbstractHemolytic disease of the fetus and newborn (HDFN) affects 3/100 000 to 80/100 000 patients per year. It is due to maternal blood group antibodies that cause fetal red cell destruction and in some cases, marrow suppression. This process leads to fetal anemia, and in severe cases can progress to edema, ascites, heart failure, and death. Infants affected with HDFN can have hyperbilirubinemia in the acute phase and hyporegenerative anemia for weeks to months after birth. The diagnosis and management of pregnant women with HDFN is based on laboratory and radiographic monitoring. Fetuses with marked anemia may require intervention with intrauterine transfusion. HDFN due to RhD can be prevented by RhIg administration. Prevention for other causal blood group specificities is less studied.

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L, Rajith M., and Punyashree R. "A clinical study of incidence and etiology of apnea in newborn." International Journal of Contemporary Pediatrics 4, no. 3 (April 25, 2017): 905. http://dx.doi.org/10.18203/2349-3291.ijcp20171696.

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Background: Apnea, defined as cessation of breathing resulting in pathological changes in heart rate and oxygen saturation, is a common occurrence especially in preterm neonates, apnea is not a disease and is a symptom of various diseases that affect neonates. Aim was to know the incidence and etiology of apnea in newborn in Indian setup.Methods: All admitted neonates who developed apnea is documented to know the incidence and selected cases were retrospectively studied to know the etiology.Results: Incidence of apnea was 19.92%, hypoxic ischaemic encephalopathy and sepsis 25.67% each were the common etiologies.Conclusions: Occurrence of apnea definitely reflects the mortality rate in newborns. Incidence of apnea in general and apnea in term newborns in particular are significantly more in comparison with western data. The association of HIE and Sepsis, the potentially preventable causes, perpetuates the incidence of term apnea reflecting the bad obstetric care, poor infrastructure, illiteracy, poor health seeking behavior affecting the child health antenataly, nataly and post nataly. Incidence of apnea in premature newborns is almost comparable to western studies. The primary apnea which is the most common cause, is an uncontrollable entity affecting similarly the newborn community of developed and developing world. India’s taboo of having high infant mortality is once again reflected in the study.

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Kiblawi, Mahmoud A., Alina Naeem, Elham A. Al Attrash, Subhranshu Kar, and B. K. M. Goud. "Complete Congenital Heart Block in a Newborn Associated with Maternal Systemic Lupus Erythematosus: A Case Report." International Journal of Medical Students 1, no. 3 (December 31, 2013): 128–31. http://dx.doi.org/10.5195/ijms.2013.220.

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Background: Complete Congenital Heart Block (CCHB) is a rare disease of the newborn that carries significant morbidity and mortality. CCHB can be diagnosed early or late in life. In newborns, it is usually associated with maternal autoantibodies or a congenital cardiac structural abnormality. The most common presentation of CCHB is bradycardia that can be diagnosed by an electrocardiogram. Results: This is a case report of a male infant born to a mother with an autoimmune disease, Systemic Lupus Erythematosus (SLE), who was found to have third degree heart block at birth. Conclusion: Early diagnosis and prompt management of the case is important for a better prognosis and prevention of associated complications. Neonates with CCHB should be managed at a tertiary care center and the only definite treatment is insertion of a pacemaker. Moreover, prenatal diagnosis and specific obstetric counseling of pregnant women with SLE along with careful monitoring with serial ultrasonography and echocardiography are of paramount importance in prevention of the disease in subsequent offspring.

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Willim, Herick Alvenus, Cristianto, and Alice Inda Supit. "Critical Congenital Heart Disease in Newborn: Early Detection, Diagnosis, and Management." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 1 (December 15, 2020): 107–16. http://dx.doi.org/10.32539/bsm.v5i1.180.

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Critical congenital heart disease (CHD) is a type of CHD that requires early intervention in the first year of life to survive. Morbidity and mortality increases significantly if newborns with critical CHD experience delay in the initial diagnosis and management. The infants may develop cyanosis, systemic hypoperfusion, or respiratory distress as the main manifestations of critical CHD. Pulse oximetry screening for early detection of critical CHD must be performed in newborns after 24 hours of age or before discharge from hospital. Generally, infants with critical CHD require patency of the ductus arteriosus with infusion of prostaglandin to maintain pulmonary or systemic blood flow. After initial management, the infants must be immediately referred to tertiary care center for definitive intervention. Keywords: congenital heart disease, duct-dependent circulation, ductus arteriosus, prostaglandin

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Kemper, Alex R., and Mark L. Hudak. "Revisiting the Approach to Newborn Screening for Critical Congenital Heart Disease." Pediatrics 141, no. 5 (April 24, 2018): e20180576. http://dx.doi.org/10.1542/peds.2018-0576.

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Abdel Raheem, MoustafaM, and WalidA Mohamed. "Impact of congenital heart disease on brain development in newborn infants." Annals of Pediatric Cardiology 5, no. 1 (2012): 21. http://dx.doi.org/10.4103/0974-2069.93705.

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Aydın, Banu. "Intussusception in a term newborn with duct-dependent congenital heart disease." Dicle Medical Journal / Dicle Tıp Dergisi 40, no. 1 (March 1, 2013): 105–8. http://dx.doi.org/10.5798/diclemedj.0921.2013.01.0233.

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Marino, Bradley S., Geoffrey L. Bird, and Gil Wernovsky. "DIAGNOSIS AND MANAGEMENT OF THE NEWBORN WITH SUSPECTED CONGENITAL HEART DISEASE." Clinics in Perinatology 28, no. 1 (March 2001): 91–136. http://dx.doi.org/10.1016/s0095-5108(05)70071-3.

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Norman, E., C. Carlén, M. Bengtsson, I. Rosén, G. Bjorkhem, and L. Hellstrom-Westas. "200 Abnormal Preoperative Eeg's In Newborn Infants with Congenital Heart Disease." Pediatric Research 56, no. 3 (September 2004): 498. http://dx.doi.org/10.1203/00006450-200409000-00223.

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Votava-Smith, Jodie K., Christopher J. Statile, Michael D. Taylor, Eileen C. King, Jesse M. Pratt, David P. Nelson, and Erik C. Michelfelder. "Impaired cerebral autoregulation in preoperative newborn infants with congenital heart disease." Journal of Thoracic and Cardiovascular Surgery 154, no. 3 (September 2017): 1038–44. http://dx.doi.org/10.1016/j.jtcvs.2017.05.045.

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Ewer, AK, LJ Middleton, S. Thangaratinam, KS Khan, and JJ Deeks. "Screening for congenital heart disease with newborn pulse oximetry – Authors' reply." Lancet 379, no. 9813 (January 2012): 311. http://dx.doi.org/10.1016/s0140-6736(12)60138-x.

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Kim, Kyoung-Nam. "Factors Affecting Adaptation in Parents of Newborn with Congenital Heart Disease." Korean Journal of Health Service Management 7, no. 3 (September 30, 2013): 111–23. http://dx.doi.org/10.12811/kshsm.2013.7.3.111.

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Hom, Lisa, and Gerard Martin. "Newborn Critical Congenital Heart Disease Screening Using Pulse Oximetry: Nursing Aspects." American Journal of Perinatology 33, no. 11 (September 2016): 1072–75. http://dx.doi.org/10.1055/s-0036-1586108.

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Congenital heart disease (CCHD) is the most common birth defect. Screening for the most critical forms (CCHD) using pulse oximetry was added to the Recommended Uniform Screening Panel in the United States in 2011. Since then, CCHD screening has become nearly universal in the United States. Nurses are ideally situated to contribute to the development of best practices for implementation and provide education to families on CCHD screening. Much of the standardization, advocacy, and development of national recommendations occurred with key input from nurses. Nurses often have responsibility for educating parents, performing the screening, interpreting the screening algorithm, and the documentation of results. The nurse role often includes implementing follow-up quality improvement initiatives to ensure that systematic and accurate screening occurs. Smooth implementation can be achieved by identifying champions early, obtaining input from a multidisciplinary team including both physician and nursing leaders, and identifying ways to integrate screening into already existing workflow. By knowing the basics of why screening is important, how to screen, current recommendations on the follow-up for positive screens and the limitations of CCHD screening, nurses can advocate for their patients and positively impact outcomes for infants born with CCHD through early identification before discharge.

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Nakagawa, Masao, Takao Yoshihara, Atsuko Matsumura, Touru Fusaoka, and Kenji Hamaoka. "Accelerated Idioventricular Rhythm in Three Newborn Infants With Congenital Heart Disease." Chest 104, no. 1 (July 1993): 322–23. http://dx.doi.org/10.1378/chest.104.1.322.

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Satomi, Gengi, Satoshi Yasukochi, Toshiro Imai, Kiyohiro Takigiku, Ishida Tekehiko, Yorikazu Harada, Takamasa Takeuchi, Makoto Watanabe, and Setsuya Ishikawa. "Interventional treatment for fetus and newborn infant with congenital heart disease." Pediatrics International 43, no. 5 (October 5, 2001): 553–57. http://dx.doi.org/10.1046/j.1442-200x.2001.01463.x.

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Journal articles on the topic 'Heart disease in the newborn'

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