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Journal articles on the topic 'Heckel plot'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Arunima, Das*1 Sayantika Chaudhuri2. "Investigating Granule Compression Dynamics: A Heckel Plot Approach to Optimize Crushing Strength in Tablet Formulations." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 286–90. https://doi.org/10.5281/zenodo.14807858.

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Tablet manufacturing is a pivotal process in the pharmaceutical industry, where granule behaviour under compression significantly influences the mechanical properties and therapeutic efficacy of the final product. This study investigates the deformation behaviour of granules, the role of porosity, and the application of the Heckel equation in understanding tablet properties. Using hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), lactose, and two different binders—starch (F1) and PVP K30 (F2)—tablets were prepared via the wet granulation method and compressed at various f

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2

Mohylyuk, Valentyn, Artūrs Paulausks, Oskars Radzins, and Liga Lauberte. "The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the Compaction and Structural–Mechanical Properties of Tablets." Pharmaceutics 16, no. 3 (2024): 362. http://dx.doi.org/10.3390/pharmaceutics16030362.

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Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of specific grades of MCC and CaHPO4 were tested in volume proportions of 100-0, 75-25, 50-50, 25-75, and 0-100 at a constant weight-by-weight concentration of sodium stearyl fumarate lubricant, utilizing a state-of-the-art benchtop compaction simulator (STYL’One Nano). Tablet formulations were prepared at 100, 1

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3

S B, Sandhan, and Wagh M P. "Comparative Study of Isomalt and Co-processed Isomalt." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 854–59. http://dx.doi.org/10.25258/ijddt.13.3.13.

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Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt. Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and elastic recovery and compared with isomalt. Result and Discussion: The co-processed isomalt demonstrated superior packing ability compared to isomalt and got rearranged in the early compression stage, as per modified Kawakita equation. Co-processed isomalt had 40% dilution potential for paracetamol as compared with

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4

Patra Ch, Niranjan, Satya Prakash Singn, Hemant Kumar P, and Vimala Devi M. "A Systematic Study on Flowability and Compressibility of Asparagus racemosus root Powder for Tablet Preparation." International Journal of Pharmaceutical Sciences and Nanotechnology 1, no. 2 (2008): 129–35. http://dx.doi.org/10.37285/ijpsn.2008.1.2.3.

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The dried root of Asparagus racemosus is widely used as mild antihypertensive and tranquilizer. The objective of the present research was to study the original flowability, compressibility and compactibility of Asparagus racemosus root powder and develop its tablet formulations by wet granulation and direct compression technology. The consolidation behavior of drug and tablet formulations were studied by using Heckel and Leuenberger equation. Asparagus racemosus root powder showed very poor flowability and compactibility. Kawakita analysis revealed improved flowability for formulations prepare

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5

NATH, RANJITA, NIRUPAM DAS, and LALDUHSANGA PACHUAU. "CELLULOSE NANOCRYSTAL-INCORPORATED CO-PROCESSED EXCIPIENT IN TABLET FORMULATION." Cellulose Chemistry and Technology 58, no. 1-2 (2024): 31–43. http://dx.doi.org/10.35812/cellulosechemtechnol.2024.58.04.

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The objective of the current work is to develop a new co-processed excipient based on cellulose nanocrystals and investigate its pharmaceutical excipient properties. Cellulose nanocrystals were isolated from the pseudostem of Musa balbisiana, following TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-mediated oxidation, and then co-processed with potato starch by the wet granulation method. Physicochemical properties, including the flow property, consolidation characteristics and rate of consolidation, were investigated, and a Kawakita plot was also generated. The compressibility, compactibility a

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6

Uwah, Timma O., Ekaete I. Akpabio, Daniel E. Ekpa, Akwaowo E. Akpabio, and Jacob Godwin. "PRELIMINARY INVESTIGATIONS INTO THE PHYSICOCHEMICAL AND COMPACTION CHARACTERISTICS OF MODIFIED STARCH OF DISCOREA ALATA USING DICLOFENAC SODIUM TABLET." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 7 (2018): 66. http://dx.doi.org/10.22159/ijpps.2018v10i7.23730.

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Objective: This work focused on evaluating the micromeritic and compressional properties of pregelatinized African water yam (Discorea alata) starch and its modified forms with comparison to pregelatinized corn starch and microcrystalline cellulose.Methods: Two modifications of the water yam starch were prepared; acetone dehydrated pregelatinized form (DSA) and an admixture of DSA and pregelatinized corn starch (CDSA). A third form of starch is the acetone dehydrated pregelatinized corn starch (CSA). These were used to form batches compacted as tablets using diclofenac sodium as the active moi

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7

Isaac, Johnson Ajeh, Kokonne Elizabeth Ekere, Ekeh Ezekiel, Isa Hayatu Galadima, Rashida Abdulahi, and Ayuba Samali. "Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves." Borneo Journal of Pharmacy 4, no. 4 (2021): 333–44. http://dx.doi.org/10.33084/bjop.v4i4.2544.

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Traditionally, the leafy part of Andrographis paniculata and Moringa oleifera have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of A. paniculata and M. oleifera were produced by compressing powders and granules at various compression pressure. Results show that M. oleifera met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moistur

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8

Prajwal, K.* Parthasarathi Kulkarni Nagendra R. Venkatesh K. Hanumanthachar Joshi. "Design And Development of Co-Processed Chitin-Lactose Monohydrate as An Excipient for Oral Dispersible Tablets." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 239–48. https://doi.org/10.5281/zenodo.14035183.

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This study describes the preparation, characterization and performance of a novel excipient for use in oral-dispersible tablets (ODT). The excipient (Cop–CLM) consists of chitin and lactose monohydrate. Specific benefits of co-processed excipients include improved flow, compressibility, disintegrating effect, and masking undesirable properties of individual excipients. The excipient with optimal physicochemical properties was obtained at a chitin: lactose monohydrate ratio of 1:2 (w/w) and produced by direct mixing. Physical properties of Co-processed chitin-lactose monohydrate (1:2 w/w)

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9

Galadima, Isa Hayatu, Isaac Ikukpla'si Ozhe, Victory Omomei Alemoh, Danraka Abubakar, and Johnson Ajeh Isaac. "Developing a solid oral dosage form with antioxidant properties from plantain peel." Nigerian Journal of Pharmacy 59, no. 1 (2025): 186–96. https://doi.org/10.51412/psnnjp.2025.18.

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Background: Plantain is used extensively for food in Nigeria due to its numerous nutritional values, which has resulted in the outer peel becoming a significant source of waste, contributing to environmental pollution. This study aimed at converting plantain peel into an oral anti-oxidant solid dosage form. Methods: First, we subjected the aqueous plantain peel extract (APPE) and the ethanolic plantain peel extract (EPPE) to phytochemical screening to test for the presence of bioactive compounds of interest. After which, we evaluated the DPPH scavenging radical activity to determine the minimu

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10

Borel, Kamga Yanick, Nguetsop Victor François, Momo Solefack Marie Caroline, and Riera Bernard. "Diversité Floristique Des Ligneux Et Structure Des Formations À Garcinia Kola Heckel Dans Les Régions Du Centre Et De l’Est, Cameroun." European Scientific Journal, ESJ 14, no. 21 (2018): 451. http://dx.doi.org/10.19044/esj.2018.v14n21p451.

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In order to find the strategies to ensure the sustainable management of natural’s resources and especially woody plants in the Congo Basin, a study was carried out on the floristic diversity of woody plants and the structure of Garcinia kola formations in the Centre and East regions of Cameroon. A total of 39 quadrats of 40 m x 40 m were installed in the Garcinia kola formations in these two regions. In each plot, we identified and counted all individuals with a dbh ≥ 10 cm. Seedlings of G. kola (dbh<10 cm) were also counted in all the plots. The height and diameter of each individual were

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11

Mohylyuk, Valentyn, and Dace Bandere. "High-Speed Tableting of High Drug-Loaded Tablets Prepared from Fluid-Bed Granulated Isoniazid." Pharmaceutics 15, no. 4 (2023): 1236. http://dx.doi.org/10.3390/pharmaceutics15041236.

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The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life constrictions on formulation scientists during product development for the generic industry, this study was done considering a common set of excipients and manufacturing operations, as well as paying special attention to the industrial-scale high-speed tableting process as one of the most critical manufacturin

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12

Paronen, Petteri. "Heckel Plots as Indicators of Elastic Properties of Pharmaceuticals." Drug Development and Industrial Pharmacy 12, no. 11-13 (1986): 1903–12. http://dx.doi.org/10.3109/03639048609042616.

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13

PERALES, MARIA DEL CARMEN MONEDERO, ANGEL MUÑOZ-RUIZ, MARIA VICTORIA VELASCO ANTEQUERA, and MARIA ROSA JIMÉNEZ-CASTELLANOS BALLESTEROS. "Study of the Compaction Mechanisms of Lactose-based Direct Compression Excipients using Indentation Hardness and Heckel Plots." Journal of Pharmacy and Pharmacology 46, no. 3 (1994): 177–81. http://dx.doi.org/10.1111/j.2042-7158.1994.tb03773.x.

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14

AHMADI, HAMED, and PAWEL WOCJAN. "ON THE QUANTUM COMPLEXITY OF EVALUATING THE TUTTE POLYNOMIAL." Journal of Knot Theory and Its Ramifications 19, no. 06 (2010): 727–37. http://dx.doi.org/10.1142/s021821651000808x.

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We show that the problem of approximately evaluating the Tutte polynomial of triangular graphs at the points (q, 1/q) of the Tutte plane is BQP-complete for (most) roots of unity q. We also consider circular graphs and show that the problem of approximately evaluating the Tutte polynomial of these graphs at the point (e2πi/5, e-2πi/5) is DQC1-complete and at points [Formula: see text] for some integer k is in BQP. To show that these problems can be solved by a quantum computer, we rely on the relation of the Tutte polynomial of a planar G graph with the Jones and HOMFLY polynomial of the alter

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15

Burkhardt, H., H. P. Tony, P. M. Aries, et al. "POS0591 SARILUMAB ATTENUATES DISEASE ACTIVITY IN SERONEGATIVE RA PATIENTS – PRELIMINARY DATA FROM A NON-INTERVENTIONAL STUDY IN REGULAR CARE IN GERMANY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 528–29. http://dx.doi.org/10.1136/annrheumdis-2021-eular.232.

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Background:Although seronegative RA patients often present with substantial disease burden [1], patients are underrepresented in research cohorts or clinical trials. Consequently, less knowledge about this subgroup has been accumulated.Objectives:To describe outcome of seronegative vs. seropositive RA patients treated with sarilumab in regular care in Germany.Methods:The prospective, observational, 24-month single-arm PROSARA study (SARILL08661) is currently running in Germany at 96 sites, aiming to enroll up to 750 RA patients treated with sarilumab. RA patients are prospectively selected at

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16

S., P. Chaudhari H. N. Dhende. "EVALUATION OF LEPIDIUM SATIVUM SEED MUCILAGE AS A BINDER IN TABLET FORMULATION." November 30, 2018. https://doi.org/10.5281/zenodo.2530472.

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The aim of the current study was to extract the mucilage from Garden Cress (Lepidium Sativum Linn) seeds and to investigate the compressional behavior of mucilage in tablet formulation in comparison with standard binder such as starch using Heckel and Kawakita plot. Using paracetamol as model drug granules was prepared with different concentration (1%, 2%, and 3%) of the mucilage and starch by wet granulation method. The granules and tablets were evaluated for their flow properties, hardness, weight variation, thickness etc., and found to have hardness and disintegration time slightly more com

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17

Sidwadkar, Prerna Hemant, Nitin Hindurao Salunkhe, Kailas Krishnat Mali, Vijay Bapu Metkari, and Durgesh Paresh Bidye. "Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation." Future Journal of Pharmaceutical Sciences 9, no. 1 (2023). http://dx.doi.org/10.1186/s43094-023-00521-0.

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Abstract Background The objective of the present investigation was to obtain directly compressible agglomerates of ibuprofen with nicotinamide by a quasi-emulsification solvent diffusion technique. Ibuprofen-nicotinamide agglomerates were prepared by quasi-emulsification solvent diffusion technique using ethanol (good solvent), water (poor solvent), and chloroform (bridging liquid). The prepared agglomerates were characterized by ATR-FTIR, powder X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy and were evaluated for tableting performance and in vitro drug

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