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Journal articles on the topic 'Hedyotis corymbosa'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Novitasari, Dhania, Sri Handayani, and Riris Istighfari Jenie. "Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells." Indonesian Journal of Cancer Chemoprevention 9, no. 1 (2018): 16. http://dx.doi.org/10.14499/indonesianjcanchemoprev9iss1pp16-22.

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Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines. The study aims to investigate whether ethanolic extract of Hedyotis corymbosa L. (EEH) performs anticancer properties by inhibiting migration and metastasis on breast cancer cells. Cytotoxic evaluation by using MTT assay was carried out to determine EEH effect on 4T1 breast cancer cells, meanwhile to investigate the treatment of EEH in migration and metastasis inhibitory effect, scratc

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2

Setiawan, Muhammad Azdar, Sernita Sernita, Agung Wibawa Mahatva Yodha, and Reymon Reymon. "ACTIVITY OF ETANOL EXTRACT OF SNAKE LID LEAVES (Hedyotis corymbosa (L.) Lamk) ON THE GROWTH OF Staphylococcus aureus BACTERIES." WARTA FARMASI 12, no. 1 (2023): 1–7. http://dx.doi.org/10.46356/wfarmasi.v12i1.235.

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Hedyotis corymbosa or commonly known as pearl grass is one of the plants that has great potential as a traditional medicine, especially in the treatment of infections. The development of infection drugs is very rapid considering that the resistance rate in several countries continues to increase. Some cases of infection that often occur are skin infections caused by Staphylococcus aureus bacteria. This study aims to test the ability of ethanol extract of snake tongue leaves in inhibiting the growth of Staphylococcus aureus bacteria. This study is an experimental study, consisting of five treat

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3

Chiu, Hui-Fen, Chun-Ching Lin, Chui-Ching Yang, and Fay Yang. "The Pharmacological and Pathological Studies on Several Hepatic Protective Crude Drugs from Taiwan (I)." American Journal of Chinese Medicine 16, no. 03n04 (1988): 127–37. http://dx.doi.org/10.1142/s0192415x88000194.

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This study is to investigate hepatic protective effect of several Taiwan crude drug extractions on the carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The pharmacological and pathological effects of Bupleurm chinense, Phellodendron wilsonii, Clematis chinensis and Hedyotis corymbosa were analyzed by liver enzyme function test and pathological studies. However, the results of amine transferase SGOT and SGPT have shown a significant hepatic protective effect after treatment with Bupleurm chinense (P<0.005), Phellodendron wilsonii (P<0.001), Clematis chinensis (P<0.005) and H

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4

Ulvia, Rengganis, Devika Nurhasanah, Azhar Camelia, and Lucia Widianingrum. "The Effect of Extraction Method on Total Flavonoid Content of Hedyotis corymbosa L." Journal of Biotechnology and Natural Science 5, no. 1 (2025): 40–47. https://doi.org/10.12928/jbns.v5i1.13187.

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Hedyotis corymbosa L. (H. corymbosa) is an Indonesian herbal plant with many health benefits. This activity comes from secondary metabolite compounds, one of which is flavonoids. These compounds can be obtained through an extraction process, where the extraction method is one of the factors that can affect the levels of compounds. This study aims to determine the effect of conventional extraction methods: maceration and soxhletation with non-conventional methods, Ultrasound Assisted Extraction (UAE) on the total flavonoid content of H. corymbose. The sample was extracted using 70% ethanol solv

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Sadasivan, Sini, P. G. Latha, J. M. Sasikumar, S. Rajashekaran, S. Shyamal, and V. J. Shine. "Hepatoprotective studies on Hedyotis corymbosa (L.) Lam." Journal of Ethnopharmacology 106, no. 2 (2006): 245–49. http://dx.doi.org/10.1016/j.jep.2006.01.002.

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6

Budhy, Theresia Indah. "THE POTENTIAL OF HEDYOTIS CORYMBOSA (L.) LAMK EXTRACT TO INHIBIT THE PROGRESSIVITY OF ORAL CANCER CELL IN RATS INDUCED WITH BENZOPYRENE." Dentika Dental Journal 19, no. 1 (2016): 22–27. http://dx.doi.org/10.32734/dentika.v19i1.142.

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Cancer is still ranked as the fifth cause of mortality and morbidityin Indonesia.Hedyotis corymbosa (L.) Lamk has ursolat acid as anti-proliferative cancer cell. This research is aimed to determine the potency of Hedyotis corymbosa (L.) Lamk at different doses, namely 375, 750, and 1500 mg/kg, used as an inhibitor for the progressivity of oral cancer, such as proliferation, angiogenesis, and apoptosis of cancer cells. Post test only control group design was used in this research. There were 24 Rattus novergicus used as research samples. Those were divided into four groups, namely control, trea

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7

Nandikar, M. D., and K. C. Kishor. "A new species and a synopsis of the Hedyotis-Oldenlandia group (Rubiaceae: Spermacoceae) in Andaman & Nicobar Islands, India." Blumea - Biodiversity, Evolution and Biogeography of Plants 64, no. 3 (2019): 225–30. http://dx.doi.org/10.3767/blumea.2019.64.03.04.

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An identification key to all the reported species of Hedyotis-Oldenlandia group (Hedyotis, Oldenlandia, Exallage, Leptopetalum, Scleromitrion and Debia) in Andaman & Nicobar Islands is presented with one new species, Oldenlandia smita-crishnae, described from Saddle Peak forests of North Andaman, India. It shares some characters with Oldenlandia herbacea, O. corymbosa and O. pseudocorymbosa. However, it is remarkable for its abaxially puberulous leaves, divaricate stipules, ellipsoid to obovoid hypanthium, pink-striped corolla lobes and 20–30-seeded, inserted capsule. Furthermore, a new co

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8

Andriyani, Rina, Chandra Risdian, and Zalinar Udin. "Cytotoxicity Assay From Fractions of Hedyotis corymbosa Extract Against Breast Cancer Cell Line T47D." Indonesian Journal of Cancer Chemoprevention 2, no. 1 (2011): 182. http://dx.doi.org/10.14499/indonesianjcanchemoprev2iss1pp182-186.

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Drug discovery for cancer medication is the most important effort that researcher do at this time. Indonesia bio diversities have possibility as a cancer medicine sources. Finding a herbal medicine for cancer treatment is a first step to find a right cancer medicine in the future. This research has already completed for the earlier another research. Some fractions of Hedyotis corymbosa extract has been analyzed using Sulforhodamine B method with UV wavelength 515 nm against T47D cell line, a human breast cancer. There are Hexane extract, Methylene chloride extract and Ethyl acetate extract, an

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9

Le, Anh Tuan, In-Lee Choi, Gyung-Deok Han, et al. "Colored LED Lights: Use One Color Alone or with Others for Growth in Hedyotis corymbosa In Vitro?" Plants 12, no. 1 (2022): 93. http://dx.doi.org/10.3390/plants12010093.

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In recent years, light-emitting diode (LED) technology has been applied to improve crop production and induce targeted biochemical or physiological responses in plants. This study investigated the effect of different ratios of blue 450 nm and red 660 nm LEDs on the overall plant growth, photosynthetic characteristics, and total triterpenoid production in the leaves of Hedyotis corymbosa in vitro plants. The results showed that a high proportion of blue LED lights had a positive effect on enhancing photosynthesis and the overall biomass. In addition, blue LED lights were shown to be more effect

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10

Meiftasari, Argandita, Januar Caesar W.P., Annisa Novarina, Julika Yovi W., and Riris Istighfari Jenie. "Ethanolic Extract of Hedyotis corymbosa and Its Combination with 5-FU Inhibit Cyclin D Expression on WiDr Colorectal Cancer Cell." Indonesian Journal of Cancer Chemoprevention 7, no. 1 (2017): 25. http://dx.doi.org/10.14499/indonesianjcanchemoprev7iss1pp25-30.

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Hedyotis corymbosa has been used for long time as an important component in several folklore medicine formula to clinically treat various types of cancer, including colorectal cancer (CRC). Previously, Hedyotis corymbosa ethanolic extract (HEE) which contain ursolic acid reported to inhibit CRC growth via induction of cancer cell apoptosis and blocked the cell cycle, preventing G1 to S progression where cyclin D highly espressed in this phase. 5-fluorouracil (5FU), the first line chemotherapy of colorectal cancer have had resistence and possessed several side effects such as neutropenia, immu

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11

LIN, Yan, Hong-Quan LI, Bo-Hou XIA, et al. "Establishing a Quality Control System of Hedyotis corymbosa." Digital Chinese Medicine 1, no. 4 (2018): 302–9. http://dx.doi.org/10.1016/s2589-3777(19)30055-2.

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12

Li, Hongquan, Chun Li, Bohou Xia, Yamin Zhou, Limei Lin, and Duanfang Liao. "A chemotaxonomic study of phytochemicals in Hedyotis corymbosa." Biochemical Systematics and Ecology 62 (October 2015): 173–77. http://dx.doi.org/10.1016/j.bse.2015.06.028.

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13

Lina, Shah Marzia Mahjabin, Imran Ashab, M. Salahuddin Bhuiya, and Masum Shahriar. "Hepatoprotective Activity of Hedyotis corymbosa (Linn.) Lam. Extract Against Anti-Tubercular Drug Induced Hepatic Damage in Sprague-Dawley Rats." Bangladesh Pharmaceutical Journal 21, no. 2 (2018): 131–38. http://dx.doi.org/10.3329/bpj.v21i2.37924.

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The aim of this study was to investigate the protective actions of hydroalcoholic extract of Hedyotis corymbosa against hepatotoxicity caused by different combinations of anti-tubercular drugs. Antitubercular drugs isoniazid and rifampicin were used to make the elevated level of ALT, AST, ALP and bilirubin as well as decreased level of albumin and total protein. Hepatoprotective activity of the plant was indicated when it causes the decrease of these marker enzymes and elevated level of albumin and total protein. H. corymbosa prevented liver damage caused by anti-tubercular drugs and also from

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14

Lin, Li-mei, Su-hui Xiong, Ling-jia Zhao, et al. "Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from Hedyotis corymbosa." Evidence-Based Complementary and Alternative Medicine 2018 (November 14, 2018): 1–10. http://dx.doi.org/10.1155/2018/8617070.

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In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from Hedyotis corymbosa (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration (X1), 30 of liquid-to-solid ratio (X2), 56°C of extraction temperature (X3), 200W of ultrasonic power (X4), 10 min of extraction time (X5), and 5 of pH value (X6). Under optimum conditions, the experimental yield (4.10 ± 0.16%) was closed to the predicted value (4.02%). The crude HCP was further purified using DEAE-52 and Sephadex G-1

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15

Jumiati, La Ode Ahmad Nur Ramadhan, and Himaniarwati. "Uji Aktivitas Ekstrak Etanol Daun Rumput Mutiara (Hedyotis corymbosa (L) Lamk.) Terhadap Bakteri Penyebab Jerawat Propionibacterium acnes dan Staphylococcus epidermidis." Jurnal Pharmacia Mandala Waluya 1, no. 4 (2022): 165–73. http://dx.doi.org/10.54883/28296850.v1i4.144.

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Jerawat merupakan kondisi pori-pori kulit tersumbat hingga mengakibatkan kantung nanah hingga terjadinya radang. Jerawat disebabkan oleh bakteri Propionibacterium acnes dan Stphylococcus epidermidis. Bakteri ini tidak patogen pada kondisi normal, tetapi jika ada perubahan keadaan kulit, maka bakteri tersebut akan menjadi invasive. Prevalensi tertinggi pada penderita jerawat antara 80-85% terjadi pada remaja usia 15-18 tahun, sebanyak 12% pada usia lebih dari 25 tahun, dan sebanyak 3% pada usia antara 35-44 tahun. Di Indonesia, catatan studi dermatologi kosmetika Indonesia memperlihatkan terdap

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16

Permana, Sofy, Laili Nurzaidah, Edwin Widodo, et al. "Anticancer activity of Hedyotis corymbosa nanoliposomes targeting estrogen receptor-alpha in breast cancer cells: In silico and in vitro studies." Journal of Pharmacy & Pharmacognosy Research 12, no. 2 (2024): 303–22. http://dx.doi.org/10.56499/jppres23.1783_12.2.303.

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Context: Breast cancer expresses high levels of the estrogen receptor alpha (ER-α). Aims: To investigate the potential anticancer activity of nanoliposome Hedyotis corymbosa in breast cancer cells by specifically targeting the ER-α through a combination of in silico and in vitro studies. Methods: This study used molecular docking to analyze the interaction between ER-α and active compounds from H. corymbosa. In vitro studies, the H. corymbosa extract was converted into nanoliposomes. The nanoliposomes' characteristics were examined, combined with tamoxifen, and applied to breast cancer cell cu

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17

Yik, Mavis Hong-Yu, Bobby Lim-Ho Kong, Tin-Yan Siu, David Tai-Wai Lau, Hui Cao, and Pang-Chui Shaw. "Differentiation of Hedyotis diffusa and Common Adulterants Based on Chloroplast Genome Sequencing and DNA Barcoding Markers." Plants 10, no. 1 (2021): 161. http://dx.doi.org/10.3390/plants10010161.

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Chinese herbal tea, also known as Liang Cha or cooling beverage, is popular in South China. It is regarded as a quick-fix remedy to relieve minor health problems. Hedyotis diffusa Willd. (colloquially Baihuasheshecao) is a common ingredient of cooling beverages. H. diffusa is also used to treat cancer and bacterial infections. Owing to the high demand for H. diffusa, two common adulterants, Hedyotis brachypoda (DC.) Sivar and Biju (colloquially Nidingjingcao) and Hedyotis corymbosa (L.) Lam. (colloquially Shuixiancao), are commonly encountered in the market. Owing to the close similarity of th

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18

Pawar, AnilT, GayatriD Gaikwad, and BhanudasS Kuchekar. "Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats." Pharmacognosy Research 10, no. 2 (2018): 213. http://dx.doi.org/10.4103/pr.pr_118_17.

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19

Desy, Ambar Sari, and Nurhayati Nurhayati. "Two anthraquinone compounds from the whole plants of Hedyotis corymbosa." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 58, no. 1 (2022): 68–72. http://dx.doi.org/10.29235/1561-8331-2022-58-1-68-72.

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20

Lee, Hye Jeong, You Mi Lee, Jong Hwan Kim, and Yang Hoon Cho. "New record of Hedyotis corymbosa, a naturalized species in Korea." Korean Journal of Plant Taxonomy 39, no. 4 (2009): 304–8. http://dx.doi.org/10.11110/kjpt.2009.39.4.304.

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21

Artanti, Nina, Muhammad Hanafi, Rina Andriyani, et al. "Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L." Journal of Tropical Life Science 5, no. 2 (2015): 88–91. http://dx.doi.org/10.11594/jtls.05.02.06.

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22

Le, Tuan Anh, Tham Thi Thu Hoang, and Hoang Ngo Phan. "Development of shoots of Hedyotis corymbosa (L) Lam in vitro culture." Science and Technology Development Journal 18, no. 4 (2015): 75–84. http://dx.doi.org/10.32508/stdj.v18i4.911.

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Hedyotis corymbosa is one of weedy herb belonging to Rubiaceae family. It has been studied and used as a traditional medicine for the treatment of snakebite, antihepatotoxic and cancer. Notably, ursolic acid and oleanolic acid, compounds presented high biological activity in H. Corymbosa, were reported having anti-inflammatory, antibacterial, antioxidant and inhibited the growth of cancer cells. In the present study, fragments of stems containing an axillary bud are cultured on MS½ medium supplemented with 1 mg/L BA and 0.2 mg/L IAA is the best condition which gives the highest number of shoot

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23

Yang, Yu-Chiao, Ming-Chi Wei, Hui-Fen Chiu, and Ting-Chia Huang. "Development and Validation of a Modified Ultrasound-Assisted Extraction Method and a HPLC Method for the Quantitative Determination of Two Triterpenic Acids in Hedyotis diffusa." Natural Product Communications 8, no. 12 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801206.

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In the present study, the oleanolic acid (OA) and ursolic acid (UA) contents of Hedyotis diffusa and H. corymbosa were determined by a rapid, selective and accurate method combining modified ultrasound-assisted extraction (MUAE) and HPLC. Compared with traditional extraction methods, MUAE reduced the extraction time, the extraction temperature and the solvent consumption and maximized the extraction yields of OA and UA. Furthermore, the combined MUAE–HPLC method was applied to quantitate OA and UA in plant samples and exhibited good repeatability, reproducibility and stability. The mean recove

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Khayer Fatema, Ummul, and Md Selim Hossain. "ANALGESIC EFFECT OF ETHANOL EXTRACT OF HEDYOTIS CORYMBOSA L. WHOLE PLANT." International Research Journal of Pharmacy 4, no. 1 (2014): 21–24. http://dx.doi.org/10.7897/2230-8407.050105.

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Md., Khalequeuzzaman, Mandal Debabrata, Nazmul Hasan2 Md., Mahfuza Khatoon Mst., and Abdur Rouf Md. "Anthelmintic and Antioxidant Activity Study of Aerial Parts of Hedyotis Corymbosa." Pharmaceutical and Chemical Journal 6, no. 2 (2019): 84–90. https://doi.org/10.5281/zenodo.13936025.

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This study was conducted to investigate phytochemical constituents, anthelmintic and antioxidant activity of aerial parts of <em>Hedyotis corymbosa</em>. Phytochemical constituents were determined by qualitative chemical tests and carbohydrate, glycoside and flavonoid were found in the methanolic and ether extracts of the aerial parts. In vitro anthelmintic activity was carried out against Pheretima posthuma. The parameters like: time of paralysis and time of death were determined by using the extract at the concentrations of 10, 25 and 50 mg/ml. The extract exhibited significant anthelmintic

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26

Jian, W. "Comparative Chemical Composition of the Essential Oils from Hedyotis Diffusa WILLD and Hedyotis Corymbosa Lam by GC-MS." International Journal of Pharmaceutical Sciences and Developmental Research 2, no. 1 (2016): 001–5. http://dx.doi.org/10.17352/ijpsdr.000004.

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27

Lau, Clara B. S., Ling Cheng, Bobby W. H. Cheng, et al. "Development of a simple chromatographic method for distinguishing between two easily confused species, Hedyotis diffusa and Hedyotis corymbosa." Natural Product Research 26, no. 15 (2011): 1446–50. http://dx.doi.org/10.1080/14786419.2011.603317.

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Lau, Clara Bik-San. "The newly discovered cytotoxic and anti-angiogenic compounds from two easily confused species, Hedyotis diffusa and Hedyotis corymbosa." European Journal of Integrative Medicine 6, no. 6 (2014): 696. http://dx.doi.org/10.1016/j.eujim.2014.09.027.

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Le, Anh Tuan, Ju-Kyung Yu, Gyung-Deok Han, Thuong Kiet Do, and Yong-Suk Chung. "Potential Use of Colored LED Lights to Increase the Production of Bioactive Metabolites Hedyotis corymbosa (L.) Lam." Plants 11, no. 2 (2022): 225. http://dx.doi.org/10.3390/plants11020225.

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Hedyotis corymbosa (L.) Lam is a wild herb that is used in traditional Indian, Chinese, and African medicine. Light-emitting diode (LED) technology is paving the way to enhance crop production and inducing targeted photomorphogenic, biochemical, or physiological responses in plants. This study examines the efficiency of H. corymbosa (L.) Lam production under blue 450 nm and red 660 nm LED lights for overall plant growth, photosynthetic characteristics, and the contents of metabolite compounds. Our research showed that blue LED lights provided a positive effect on enhancing plant growth and ove

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Zhu, Yingjia. "A comparative study on antimicrobial effects of Rubiaceae plants." Theoretical and Natural Science 48, no. 1 (2024): 118–23. http://dx.doi.org/10.54254/2753-8818/48/20240217.

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Traditional Chinese Medicine (TCM) has accumulated valuable experience from ancient China while mixed with impurities. Plants from the Rubiaceae family are widely distributed in China, with a long history of use and a significant amount of related literature on Traditional Chinese Medicine. This study used ethanol extracts from three Rubiaceae plants, namely Galium spurium L., Rubia cordifolia L., and Hedyotis corymbosa L., to conduct antimicrobial experiments against Escherichia coli and Bacillus subtilis. Among them, G. spurium and R. cordifolia were confirmed to have antimicrobial capabilit

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Zhu, Yingjia. "A comparative study on antimicrobial effects of Rubiaceae plants." Theoretical and Natural Science 40, no. 1 (2024): 64–69. http://dx.doi.org/10.54254/2753-8818/40/20240217.

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Traditional Chinese Medicine (TCM) has accumulated valuable experience from ancient China while mixed with impurities. Plants from the Rubiaceae family are widely distributed in China, with a long history of use and a significant amount of related literature on Traditional Chinese Medicine. This study used ethanol extracts from three Rubiaceae plants, namely Galium spurium L., Rubia cordifolia L., and Hedyotis corymbosa L., to conduct antimicrobial experiments against Escherichia coli and Bacillus subtilis. Among them, G. spurium and R. cordifolia were confirmed to have antimicrobial capabilit

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Filawati, Filawati. "Pengaruh Suplementasi Rumput Mutiara (Hedyotis corymbosa) dalam Ransum terhadap Penampilan Ayam Broiler." Jurnal Ilmiah Ilmu-Ilmu Peternakan 12, no. 2 (2009): 96–105. http://dx.doi.org/10.22437/jiiip.v0i0.479.

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The present study was conducted to determine the effect of pearl grass (Hedyotis corymbosa) supplementation into the ration on the broiler performance. The study was carried out in the cages under Laboratory of Poultry and Non Ruminant Nutrition and Laboratory of Feed Science, Department ofAnimal Nutrition and Feed Science, Faculty of Animal Science, University of Jambi for 5 months. The study used 2-day of broiler chicken strain MB 202 which fed basal ration. The basal ration contained yellow maize, rice bran, fish meal, soybean meal, Top mix, mineral mix, coconut meal and calciumdiphosphat.

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Marfan, La Ode, Wa Ode Ida Fitriah, Juliana Baco, Dian Rahmaniar Trisnaputri, Firhani Anggriani Syafrie, and Fitriani W.Alani. "Uji Aktivitas Antijamur Fraksi n-Heksan, Etil asetat, dan Air Herba Rumput Mutiara (Hedyotis corymbosa L.) Terhadap Pertumbuhan Jamur Candida albicans." Jurnal Pharmacia Mandala Waluya 3, no. 3 (2024): 200–213. http://dx.doi.org/10.54883/jpmw.v3i3.150.

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Penyakit infeksi merupakan jenis penyakit yang mudah menyerang manusia. Salah satu infeksi yang banyak ditemukan adalah infeksi yang disebabkan oleh jamur Candida albicans. Penelitian ini bertujuan untuk mengetahui golongan senyawa kimia yang terdapat pada fraksi n-heksan, etil asetat, dan air dari ekstrak herba rumput mutiara (Hedyotis corymbosa L.), dan mengetahui konsentrasi optimal serta fraksi mana yang memilki aktivitas antijamur paling baik sebagai penghambat jamur Candida albicans. Penelitian ini adalah penelitian eksperimental Laboratorium. Proses ekstraksi menggunakan metode maserasi

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Wang, Yaru, Cuizhu Wang, Hongqiang Lin, et al. "Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis." Molecules 23, no. 7 (2018): 1525. http://dx.doi.org/10.3390/molecules23071525.

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Bahtiar, Anton, Fitri Arum Sari, Mega Audina Putri, Natasha Linsie Corona Datunsolang, and Ade Arsianti. "ETHANOLIC EXTRACTS OF HEDYOTIS CORYMBOSA L. IMPROVES MONOSODIUM IODOACETATE-INDUCE OSTEOARTHRITIS IN RAT." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 473. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16558.

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ABSTRACTObjective: The objective of this study is to explore the effects of the 70% ethanolic extract of pearl grass on the immune system of the osteoarthritismodel rat, characterized by the number of leukocytes and lymphocytes, and the histology of the joint. Osteoarthritis is a degenerative diseasecharacterized by chronic inflammation in the joints. Based on the daily practice of herbal medicine in some community in Indonesia, pearl grassusually used for anti-inflammation but not a lot of data to support it.Methods: We used 36 male rats Sprague-Dawley strain divided into 6 groups. Normal gro

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Sivarajan, V. V., and S. D. Biju. "TAXONOMIC AND NOMENCLATURAL NOTES ON THE HEDYOTIS CORYMBOSA‐DIFFUSA COMPLEX (RUBIACEAE) IN INDIA." TAXON 39, no. 4 (1990): 665–74. http://dx.doi.org/10.1002/j.1996-8175.1990.tb01100.x.

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Wei, Ming-Chi, and Yu-Chiao Yang. "Kinetic studies for ultrasound-assisted supercritical carbon dioxide extraction of triterpenic acids from healthy tea ingredient Hedyotis diffusa and Hedyotis corymbosa." Separation and Purification Technology 142 (March 2015): 316–25. http://dx.doi.org/10.1016/j.seppur.2015.01.008.

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Lin, Chun-Ching, Lean-Teik Ng, and Jenq-Jer Yang. "Antioxidant Activity of Extracts of Peh-Hue-Juwa-Chi-Cao in a Cell Free System." American Journal of Chinese Medicine 32, no. 03 (2004): 339–49. http://dx.doi.org/10.1142/s0192415x04001990.

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In traditional Chinese medicine preparations, Hedyotis diffusa (HD), Hedyotis corymbosa (HC) and Mollugo pentaphylla (MP) are often used interchangeably under the name of "Peh-Hue-Juwa-Chi-Cao (PHJCC)." Although studies have been conducted to characterize the therapeutic activities of these different plant species, their antioxidant activity has never been investigated. In this study, our aim was to evaluate the antioxidant and free radical scavenging activities of these three different plant materials. At a concentration of 10 mg/ml, results showed that HD possesses the strongest inhibition o

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Lin, Chun-Ching, Lean-Teik Ng, Jenq-Jer Yang, and Yu-Fang Hsu. "Anti-Inflammatory and Hepatoprotective Activity of Peh-Hue-Juwa-Chi-Cao in Male Rats." American Journal of Chinese Medicine 30, no. 02n03 (2002): 225–34. http://dx.doi.org/10.1142/s0192415x02000405.

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Peh-Hue-Juwa-Chi-Cao (PHJCC) is a common commercial name for the herbal extract of either Hedyotis diffusa (HD), H. corymbosa (HC), or Mollugo pentaphylla (MP). The present study was carried out to investigate the anti-inflammatory and hepatoprotective effects of these three extracts in rats. The results indicated that extracts of HC, HD and MP possess anti-inflammatory activity, and that MP has the greatest inhibition against carrageenan-induced paw edema. In the hepatoprotective study, results indicated that the three plant extracts significantly reduced the acute elevation of serum glutamat

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Aprianto, Yoce, Asri Mega Putri, Hilyatul Fadliyah, Retno Murwanti, and Edy Meiyanto. "Antigenotoxic Activity of Rumput Mutiara (Hedyotis corymbosa L.) Ethanolic Extract on Cyclophosphamide-Induced Mice." Indonesian Journal of Cancer Chemoprevention 8, no. 3 (2018): 135. http://dx.doi.org/10.14499/indonesianjcanchemoprev8iss3pp135-145.

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Exposure to relative chemicals has been shown to induce a genotoxic effect that can be observed through formation of micronucleus (MN) in polychromatic erythrocythes (PCE). Rumput Mutiara or Hedyotis corymbosa L. ethanolic extract (HcEE) is known to contain ursolic acid as major compound that possesses antigenotoxic activity on HepG2 cells. This study exerts in vivo approach aiming to evaluate the antigenotoxic effects of HcEE on cyclophosphamide (CP)-induced male Swiss mice. The ursolic acid on HcEE was determined by using thin layer chromatography with silica gel as stationary phase and chlo

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Yang, Yu-Chiao, Chia-Sui Wang, and Ming-Chi Wei. "Validation of a greener procedure for the extraction of triterpenic acids from Hedyotis corymbosa." Microchemical Journal 165 (June 2021): 106062. http://dx.doi.org/10.1016/j.microc.2021.106062.

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Viogenta, Pratika, Siti Nurjanah, and Yuli Wahyu Tri Mulyani. "Isolasi Jamur Endofitik Rumput Mutiara (Hedyotis corymbosa (L.) Lamk.) dan Analisis Potensi Sebagai Antimikroba." Jurnal Pharmascience 7, no. 1 (2020): 72. http://dx.doi.org/10.20527/jps.v7i1.8076.

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ABSTRAK Jamur endofit merupakan jamur yang hidup di dalam jaringan atau organ tanaman yang tidak bersifat patogen. Jamur ini dapat menghasilkan beberapa zat yang sama seperti tanamannya. Rumput mutiara (Hedyotis corymbosa (L.) Lamk) merupakan jenis rumput liar yang biasa hidup di tanah lembab. Tujuan penelitian ini adalah untuk mengetahui keanekaragaman mikroba endofit rumput mutiara. Metode dari penelitian ini meliputi isolasi jamur endofit dari batang, daun, akar, bunga rumput mutiara, identifikasi jamur yang berhasil diisolasi, pengukuran diameter laju pertumbuhan jamur endofit dan uji daya

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Gupta, Ramesh Kr, Rajnish Kr Singh, Sudhansu Ranjan Swain, Talib Hussain, and Chandana Venkateswara Rao. "Anti–hepatotoxic potential of Hedyotis corymbosa against D–galactosamine–induced hepatopathy in experimental rodents." Asian Pacific Journal of Tropical Biomedicine 2, no. 3 (2012): S1542—S1547. http://dx.doi.org/10.1016/s2221-1691(12)60450-x.

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Norrizah, J. S., M. Yaseer Suh, A. Rohaya, and N. A. R. Nik Roslan. "Ursolic Acid and Oleanolic Acid Productions in Elicited Cell Suspension Cultures of Hedyotis corymbosa." Biotechnology(Faisalabad) 11, no. 4 (2012): 238–42. http://dx.doi.org/10.3923/biotech.2012.238.242.

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Ardiani, Rani. "UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RUMPUT MUTIARA (Hedyotis corymbosa L. Lamk) TERHADAP TIKUS PUTIH." Jurnal Penelitian Farmasi & Herbal 5, no. 1 (2022): 5–9. http://dx.doi.org/10.36656/jpfh.v5i1.858.

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Inflamation is the body’s defense mechanism in response to tissue injury and interference by external factors. Pearl grass (Hedyotis Corymbosa L.Lamk) is one of Rubiaceae family. Pearl grass have efficacy in the treatment as anti-inflamatory, anti-diabetic, anti-bacteria, and antioxidant. Pearl grass contains flavonoids has pharmacological effects as a anti-inflamatory. The purpose of this study was to determine the anti-inflamatory effect of ethanolic extract of pearl grass (EERM) on white rats incuded by λ- carragenan.This research was conducted by experimental method which included pearl gr

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Seniwaty, Raihanah, Kusuma Nugraheni Ika, and Umaningrum Dewi. "SKRINING FITOKIMIA DARI ALANG-ALANG (Imperata Cylindrica L.Beauv) DAN LIDAH ULAR (Hedyotis Corymbosa L.Lamk)." Jurnal Ilmiah Berkala Sains dan Terapan Kimia 3, no. 2 (2009): 124–33. https://doi.org/10.5281/zenodo.823379.

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Berbagai jenis tumbuhan dapat digunakan sebagai obat yang kita kenal sebagai obat tradisional. Penggunaan obat tradisional oleh masyarakat sampai sekarang terus meningkat. Indonesia sangat kaya dengan tanaman yang digunakan sebagai obat. Salah satu tanaman yang biasa digunakan sebagai obat oleh masyarakat Indonesia untuk berbagai macam keluhan dan penyakit adalah tanaman alang-alang (Imperata Cylindrica L. Beauv) dan lidah ular (Hedyotis Corymbosa L. Lamk). Penelitian ini bertujuan untuk memberikan informasi ilmiah kandungan senyawa sekunder dari tanaman alang-alang dan lidah ular. Penelitian

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Lee, Hong-Zin, Da-Tian Bau, Chao-Lin Kuo, Ru-Yin Tsai, Yu-Chang Chen, and Yu-Hao Chang. "Clarification of the Phenotypic Characteristics and Anti-Tumor Activity of Hedyotis diffusa." American Journal of Chinese Medicine 39, no. 01 (2011): 201–13. http://dx.doi.org/10.1142/s0192415x11008750.

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Hedyotis diffusa Willd. (Rubiaceae) is an important folk herb used to prevent and cure hepatitis and liver cancer in Taiwan. For differentiation of H. diffusa from counterfeits, macroscopic and microscopic characters of H. diffusa, H. corymbosa and H. tenelliflora were examined in this study. According to Trypan blue exclusion assay and Western blot analysis, H. diffusa had a significant inhibition of cell growth and induction of cell apoptosis in COLO 205 (colon cancer), Hep 3B (hepatocellular carcinoma) and H460 (lung cancer) cell lines. This study also used high-performance liquid chromatog

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Sari, Desy Ambar, Harijono Harijono, and Chi-I. Chang. "Evaluation of antibacterial activities from major bioactive constituents of the whole plant of Hedyotis corymbosa." Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering 2, no. 2 (2019): 39–42. http://dx.doi.org/10.21776/ub.afssaae.2019.002.02.1.

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Wijayanti, Titik. "SKRINING SENYAWA METABOLIT SEKUNDER EKSTRAK RUMPUT MUTIARA (Hedyotis Corymbosa (L.) Lamk.) DENGAN METODE GC-MS." Florea : Jurnal Biologi dan Pembelajarannya 4, no. 1 (2017): 24. http://dx.doi.org/10.25273/florea.v4i1.1057.

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<p align="center"><strong>ABSTRAK</strong></p> Penelitian dilaksanakan bertujuan untuk mengeksplorasi potensi senyawa metabolit sekunder tanaman rumput mutiara (<em>Hedyotis corymbosa</em> (L.) Lamk.) dalam bentuk esktrak. Penelitian ini diharapkan memberikan informasi yang lebih lengkap terhadap potensi penggunaan tanaman tersebut sebagai obat tradisional. Identifikasi komponen senyawa metabolit sekunder dilakukan dengan metode Gas Chromatograph Mass Spectrometri (GCMS). Hasil GCMS menunjukkan terdapat 20 senyawa yang terindetifikasi yang berasal dari golon

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Mishra, Kirti, Aditya P. Dash, Bijay K. Swain, and Nrisingha Dey. "Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin." Malaria Journal 8, no. 1 (2009): 26. http://dx.doi.org/10.1186/1475-2875-8-26.

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