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Dissertations / Theses on the topic 'HeLa cancer Cell'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Flynn, Patrick G. "Activation of Non-Muscle Myosin IIB Helps Mediate TNF-Alpha Cell Death Signaling." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/369.

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TNF-alpha can stimulate a variety of kinases with the ability to activate non-muscle myosin II. As a result, increases in actin filament formation and actomyosin contractility (AMC) have been reported in response to TNF-alpha. These events are thought to play an important role in mediating TNF-alpha induced apoptosis but how they do so is unclear. In this study we prevented non-muscle myosin II activation in response to TNF-alpha by treating cells with the myosin light chain kinase (MLCK) inhibitor ML-7 or through isoform specific siRNA knockdown of myosin IIA and IIB. We found that treatme

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2

Tabbaa, Mahmmoud M. "Pyrithione Zinc effect on Cancer Cell Proliferation and Viability." Ohio University Art and Sciences Honors Theses / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1509614945218889.

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3

Robeson, Kalen Z. "Development of a Fast and Accurate Mutation Assay in Human Cell Lines." Ohio University Honors Tutorial College / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors149270391894463.

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4

Wortmann, Andreas. "In vitro and in vivo examination of the cell surface glycoprotein CDCP1." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/40975/1/Andreas_Wortmann_Thesis.pdf.

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A number of reports have demonstrated the importance of the CUB domaincontaining protein 1 (CDCP1) in facilitating cancer progression in animal models and the potential of this protein as a prognostic marker in several malignancies. CDCP1 facilitates metastasis formation in animal models by negatively regulating anoikis, a type of apoptosis triggered by the loss of attachment signalling from cell-cell contacts or cell-extra cellular matrix (ECM) contacts. Due to the important role CDCP1 plays in cancer progression in model systems, it is considered a potential drug target to prevent the metast

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5

Viglianti, L. "THE HETEROARYLETHENES: SYNTHESIS, ELECTROCHEMISTRY AND INVESTIGATION ON THE AGGREGATION-INDUCED EMISSION OF A PROMISING CLASS OF MOLECULES WITH LUMINESCENT PROPERTIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/338784.

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The present research has been aimed on the synthesis and to the electrochemical and photophysical investigation of the HeteroArylEthene class constituted by the DiThienylEthene DTE, TriThienylEthene TrTE, TetraThienylEthene TTE, DiFurylEthene DFE, TriFurylEthene TrFE and TetraFurylEthene TFE. The study includes as a benchmark the analogous phenyl-based series which was already well known concerning the synthesis the photophysical properties and the applications. A very limited knowledge was so far available concerning the heteroaryl-based ethenes. Among the investigated systems, TFE and TrTE

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6

Lewis, Tyler E. "Investigation of Parameters Affecting the Nanoinjection of HeLa 229 Cancer Cells." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5526.

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The ability to deliver sequences of DNA and other molecular loads across the membrane of a cell and into its nucleus is an area of interest in the medical community. One of its many applications is that of gene therapy. In contrast to other forms of treatment, gene therapy seeks to treat diseases at the cellular level. The success of these treatments depends on the technologies for cell transfection that are available. Physical methods are sometimes able to overcome poor efficiencies of chemical methods and the safety concerns of viral methods, but are usually impractical due to the limited nu

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7

Hayes, Mark Thomas. "Investigation of the mechanisms of the genotoxicity and cytotoxicity of selected anticancer agents in human cells." Thesis, Queensland University of Technology, 1999.

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8

Feni, Lucia [Verfasser], Ines [Gutachter] Neundorf, and Norbert [Gutachter] Sewald. "Improving cargo delivery in cancer therapy with the help of cell-penetrating peptides / Lucia Feni ; Gutachter: Ines Neundorf, Norbert Sewald." Köln : Universitäts- und Stadtbibliothek Köln, 2019. http://d-nb.info/1191365670/34.

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9

Castro, Arce Johanna de. "RAR beta trans-repression of AP-1 transcription factor in HeLa cervical cancer cells consequences on transcription of viral and cellular AP-1 controlled genes /." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10806332.

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10

Ryan, Joseph Anthony. "Quantification via Inductively-Coupled Plasma Optical Emission Spectroscopy (ICP-OES) of the Cellular Internalization and Nuclear Localization of Gold Nanoparticles Passivated with BSA-SV40 Large T NLS Conjugates after Incubation with Human Cervical Cancer (HeLa) Cells." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-06132009-145408/.

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Rhodamine-labeled, cysteine-modified SV40 large T NLS peptide sequences were conjugated in varying amounts (~ 3 to 15 molar ratio) with bovine serum albuin (BSA) via the heterobifunctional linker succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC). These conjugates were then used to passivate nanomolar aliquots of citrate-coated gold nanoparticles of varying diameter (5, 10, 15, and 20 nm), and the stability of these nanoparticle complexes were evaluated with respect to: 1) amount of large T-BSA per nanoparticle (found to be stable under the following BSA:nanoparticle ratios: 5

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11

Otto, Lilli Luise [Verfasser], Susanne [Akademischer Betreuer] Sebens, and Janka [Gutachter] Held-Feindt. "Diabetes mellitus as risk factor for pancreatic cancer : Impact of hyperglycaemia on the phenotype of macrophages and their influence on pancreatic ductal epithelial cells / Lilli Luise Otto ; Gutachter: Janka Held-Feindt ; Betreuer: Susanne Sebens." Kiel : Universitätsbibliothek Kiel, 2020. http://d-nb.info/123768563X/34.

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12

Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive<br/>form (150 kDa) and a truncated non-catalytic form (50 kDa). The two<br/>variants show different 3'UTR regions, indicating that they might be differentially<br/>regulated at the post-transcriptional level. In this work we explore how<br/>microRNAs take part in the regulation of full-length and truncated NTRK3,<br/>demonstrating that the two isof

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13

Malemela, Kholofelo Mmanoko. "Investigation of the probable anti-cancer effects of the crude methanol extract of dicerocaryum senecioides, (Klotzch) J. Abels, leaves on cervical HeLa cancer cell." Thesis, 2018. http://hdl.handle.net/10386/2205.

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Thesis (M.Sc. (Biochemistry) -- University of Limpopo, 2018<br>Dicerocaryum senecioides is a plant widely used as a nutritional source. It is used also for treatment of measles, wounds and to facilitate birth in domestic animal and humans in many parts of southern Africa (Mampuru et al., 2012). Findings in our laboratory have shown that a dichloromethane fraction of D. senecioides possesses antiinflammatory properties in human t-lymphocytes (Madiga, 2009), while the methanol crude extract possesses anti-proliferative and proapoptotic properties against Jurkat T cancer cells (Mphahlele, 2008).

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Silva, Lídia Jorge Santos 1989. "Metabolic switch in uterine cervix cancer: in vitro study of adenocarcinoma (HeLa) and squamous cell carcinoma (SiHa) cell lines." Master's thesis, 2012. http://hdl.handle.net/10451/7527.

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Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2012<br>O cancro é uma doença complexa que envolve numerosas alterações na fisiologia da célula que conduzem, em última instância, a tumores malignos. Os processos biológicos através dos quais as células normais são transformadas em células cancerígenas malignas têm sido alvo de vasta investigação durante várias décadas (Seyfried & Shelton, 2010). Existem seis alterações essenciais na fisiologia celular que estão na base do crescimento celular maligno e são a auto-suficiência em termos de si

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15

Liao, Hsuen-Jen, and 廖宣任. "Growth inhibition effect of human NAP1 gene in HeLa cancer cell and tumor-bearing mice." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/57c348.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>Two human nitrilase homologs have been identified and named as Nit1 and Nap1. hNit1 has been characterized with the function of tumor suppressing mainly through apoptosis to inhibit cell growth；functions of hNap1 are under investigation. According to the research of our lab, overexppressing Nap1 in HeLa cell caused the cell cycle arrested at G2/M phase which resulted in inhibiting cell growth. In the present study, the aim is to verify that NAP1 gene is with the function of tumor suppressing in animal xenograft model. First, we chose a plasmid whic

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16

HUAN, CHEN JOU, and 陳柔亘. "The molecular mechanisms of S phase cell cycle arrest and apoptosis by crude extract of Euphorbia antiquorum in Human Cervical Cancer Cells (HeLa)." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/10615664624778333192.

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碩士<br>中國醫藥大學<br>醫學研究所<br>93<br>Cervical cancer is the first popular cancer of women in the world and is harmful to the health of human beings. It/s infective rate is the index of the level of medical care and popular health quality of a country. In our preliminary studies, we found Euphorbia antiquorum (EA) could induce cell cycle arrest and apoptosis in human cervical cell lines. EA has been used to treat tumor, tinea, gastroenteritis, cholera, and malaria in the world including Taiwan for a long time. In this work, we studied EA cytotoxic effect on human cervical HeLa cells and the underlyin

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17

Huang, Ching-Chih, and 黃慶芝. "Functional proteomic analysis of cervical cancer cell line - HeLa under genotoxic stress or interruption of Nampt/visfatin activity by FK866." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/10494312072639456843.

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碩士<br>銘傳大學<br>生物科技學系碩士班<br>103<br>Several studies have shown that carcinogenic cells will increase the expression of Nicotinamide phosphoribosyl transferase (Nampt) level, but less research has explored the relationship between cancer and Nampt from proteomic studies. Ourprevious study has found that the protein level of Nampt in HeLa cell is prominently more than the other tested cell lines, but we the biological role of Nampt in HeLa cells remained to be determined. First, we try to examine what Nampt response in HeLa cells under genotoxic stress. We found that the protein level of Nampt has

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18

Hung, Ray-Ping, and 洪瑞萍. "The study of anti-cancer mechanism of anonaine on human cervical cancer HeLa cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/pk35sm.

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碩士<br>輔英科技大學<br>醫事技術系碩士班<br>96<br>Anonaine, extracted from Michelia alba D.C. (Magnoliaceae), possesses some biological and pharmacological activities, but the mechanisms by which anonaine induces cell death in human cancer cells remains poorly understood. In this study, we investigated the mechanisms of apoptosis induced by anonaine in human cervical HeLa cancer cells. Treatment with anonaine induced by anonaine treatment was gound dose-dependent and correlated well with the increase intracellular nitric oxide (NO), reactive oxygen species (ROS), glutathione (GSH) depletion, disruptive mitoch

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19

Yang, Chun-ting, and 楊俊廷. "The role of stroma cells in radio-sensitivity of cervical cancer HeLa cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/75069684690592311309.

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碩士<br>慈濟大學<br>分子生物暨人類遺傳學系碩士班<br>99<br>Radiotherapy is one of effective treatments for patients with cervical cancers, especially for those with direct invasion or distal metastasis. However, outcome of radiotherapy is not consistent. In this study, role of stromal cells in radio-sensitivity of cervical cancer HeLa cells cultured in condition media (CMs) derived form coculture of HeLa cells and stromal cells were investigated. To prepare conditioned media from stromal cells or mixcultures (Stromal cells : HeLa cells = 1:1), stromal cells prepared from stromal cells closed to the cervical tumor

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20

Kuo, I.-Ting, and 郭奕廷. "Fabrication of Magnetic CNTs and Interaction with A549 and HeLa Cancer Cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/78104858148571676298.

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碩士<br>國立交通大學<br>應用化學研究所<br>98<br>Carbon nanotubes (CNTs) have strong absorbances in near-infrared (NIR) region, a great biocompatibility and the surface can be modified easily by biomolecular. These unique properties make CNTs promising candidates for multifunctional biological transporters and thermal cancer cell killers. Incorporating Fe3O4 nanoparticles into the CNTs can enhance effective CNT separation by magnetism. Therefore, here we report the synthesis of magnetic carbon nanotubes (MCNTs) by using chemical vapor deposition (CVD) and chemical coprecipitation for biomedical applications.

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21

Teixeira, Paulo Fernando Miranda da Cunha. ""Caracterização imunocitoquímica de marcadores celulares estaminais do cancro - estudo in vitro na linha celular HeLa exposta a radiação e a quimioterapia"." Master's thesis, 2019. http://hdl.handle.net/10316/89996.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>O cancro do colo do útero, é a terceira neoplasia maligna mais comum na mulher no mundo. A doença na fase inicial é curável através de procedimentos cirúrgicos ambulatórios, no entanto, quando as lesões são invasivas as opções terapêuticas incluem radioterapia e quimioterapia, não sendo incomum a recidiva local ou a metastização tanto loco regional como à distância, após o tratamento.As causas para o insucesso do tratamento são conhecidas e relacionam-se, entre outras, com alterações genéticas e epigenétic

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22

Yeh, Shin-Chi, and 葉欣綺. "Effect of Narrow Bandwidth Infrared Radiation on the Cervical Cancer Cells Hela Expressions." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/15124620761272236167.

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碩士<br>國立臺灣大學<br>生醫電子與資訊學研究所<br>102<br>The purpose of this research is to study the infrared irradiation effect on the cervical cancer cells Hela growth and migration. The plasmonic thermal emitter with broad bandwidth (3~3.8 μm) and narrow emission waveband (3.8, 4.4, 4.8 μm) were designed and used to illuminate the cells for 48 hours to investigate the specific wavelength that affects the cell expression most significantly. Infrared emitters used in this study are fabricated based on the theory of surface plasmon. The infrared source can be achieved by heating the triple layer structure which

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23

Wu, Sung-en, and 吳宋恩. "Dibenzoylmethane and its analogues suppress in vitro metastasis of human HeLa cervical cancer cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/30629743350820125249.

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碩士<br>朝陽科技大學<br>應用化學系生化科技碩士班<br>101<br>Dibenzoylmethane (DBM) is extracted from Glycyrrhiza glabra and its structure is similar to curcumin. It has been shown to exhibit antineoplastic effects, cell cycle arrest and apoptosis. Metastatic cervical cancer often is difficult to treat and a poor prognosis. Therefore, the inhibition of metastasis could prevent tumor progression. In this study, we investigated the effects of DBM and its analogues including 1-(2-Hydroxyphenyl)-3-phenyl-1,3-propanedione (HDB) and 1-(2-Hydroxyphenyl-5-methylphenyl)-3-phenyl-1,3-propanedione (HMDB) on the metastasis of

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Salvada, André Alexandre Ferreira. "XPC down-regulation in cisplatin-exposed HeLa cells and its implications on cervical cancer therapy." Master's thesis, 2018. http://hdl.handle.net/10316/89774.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>INTRODUCTION: Cisplatin(CDDP)-based chemotherapy remains the standard treatment for patients with advanced or recurrent cervical cancer (CC) not amenable to curative therapies. Metastatic CC is still associated with poor survival rates, partly due to CDDP-resistance (CPR), which seriously compromises the efficacy of treatment. XPC, a member of the nucleotide excision repair (NER) pathway, identifies CDDP adducts and may have a role in CPR, along with Akt and AMPK, as regulators of XPC expression. OBJECTIVES

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25

Ndlovu, Mxolisi Justice. "Screening of the crude acetone extracts of toona ciliata, seriphium plumosum and schkuhria pinnata for their potential anticancer activities against hela cervical cancer cells." Thesis, 2019. http://hdl.handle.net/10386/3164.

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Thesis (M. Sc. (Biochemistry)) -- University of Limpopo, 2019<br>Cervical cancer is the fourth most common cancer in females, and the seventh of all cancer types in both genders, with an estimated 500,000 new cases each year. As with liver cancer, a large majority (around 85%) of the global burden occurs in the less developed regions, where it accounts for almost 12% of all female cancers. About 90% of cervical cases are associated with human papillomavirus (HPV) as a causative agent and this virus is frequently transmitted through sexual contact involving exchange of fluids (Walboomers et al.

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26

Zheng, Guang-hui, and 鄭光輝. "Induction of Apoptosis and Changes in Differentiation Status by Retinoic Acid in Human Cervical Cancer HeLa Cells." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/89125117535345649842.

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碩士<br>國防醫學院<br>生物化學研究所<br>84<br>In the treatment of cervical cancer, the recently focused apo- ptosis might provide a potential route to eliminate the malign- ant cells. In addition, tumorigenesis is usually associated with progression toward de-differentiation, so the alternative may be induction of re-differentiation in tumor cells, or return to the normal cell cycle. Retinoic acid (RA) is known to exert a variety of biological functions, including embryonic development, protecting non-ep

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27

Phillip, Roy, Myra Zahid, and Lijun Shang. "Cytotoxicity of in vitro exposure of polystyrene latex bead nanoparticles to human keratinocyte (HaCaT) cells and human cervical cancer (HeLa)cells." 2016. http://hdl.handle.net/10454/10911.

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yes<br>Nanoparticles are increasingly used in industry and medicine due to their unique physiochemical properties such as their small size, charge, shape, chemical architecture, large surface area, surface reactivity and media interactions, etc [1-5]. However, very little is still known on the interactions between nanoparticles and the biological system. This study aims to evaluate the cytotoxicity of polystyrene latex bead nanoparticles on HaCat and HeLa cell lines. Carboxyl-modified 20 nm polystyrene NPs core labelled with fluorophore were from Invitogen. We chose to use polystyrene NPs

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28

"Study of SUMOylation in HPV-positive human cervical carcinoma HeLa by comparative proteomics and biarsenical-tetracysteine fluorescent labeling system." 2007. http://library.cuhk.edu.hk/record=b5896736.

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Chan, Ho Yin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 263-283).<br>Abstracts in English and Chinese.<br>Examination Committee List --- p.i<br>Acknowledgements --- p.ii<br>Abstract --- p.iv<br>摘要 --- p.vi<br>Table of Contents --- p.viii<br>List of Abbreviations --- p.xvii<br>List of Figures --- p.xx<br>List of Tables --- p.xxv<br>Chapter Chapter I --- Introduction --- p.1<br>Chapter 1.1 --- SUMO (Small Ubiquitin-like Modifier) and SUMOylation --- p.1<br>Chapter 1.1.1 --- "Ubiquitin, Ubiquitin-like proteins and SUMO iso

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29

Castro, Arce Johanna De [Verfasser]. "RARβ [RAR-beta] trans-repression of AP-1 transcription factor in HeLa cervical cancer cells : consequences on transcription of viral and cellular AP-1 controlled genes / presented by Johanna De Castro Arce". 2003. http://d-nb.info/969236875/34.

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30

Capasso, Giovanni. "STUDIO MOLECOLARE DEGLI EFFETTI DEI TOCOTRIENOLI E DELLA TRF (TOCOTRIENOL-RICH FRACTION), ESTRATTI DALL’OLIO DI PALMA (E. guineensis), SULL’INDUZIONE DELLO STRESS DEL RETICOLO ENDOPLASMATICO IN CELLULE UMANE DI CANCRO DELLA CERVICE UTERINA (HeLa cells)." Tesi di dottorato, 2014. http://www.fedoa.unina.it/9750/1/tesi-Capasso%20Giovanni.pdf.

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I tocotrienoli differiscono dai tocotrienoli tra loro per l’insaturazione della catena fitilica laterale. È noto un ampio insieme di proprietà biologiche delle prime isoforme che non sono espresse dai tocoferoli, i cui meccanismi molecolari d’azione sono ancora scarsamente compresi. Recentemente, sulla base delle evidenze sperimentali derivanti da studi in silico e in vitro, è stato evidenziato che gli effetti di forme specifiche di tocotrienoli (γ- e δ-tocotrienolo) sull’espressione genica è mediata, almeno in parte, dall’attivazione del recettore β degli estrogeni in cellule delle linee MDA-

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Valayil, Jinu Mathew. "Structure Elucidation and Biological Evaluation of a Novel Steroidal Saponin, Cholestanol Glucoside Isolated from Saraca Asoca Enodophytic Fuungus, Lasiodiplodia Theobromae." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3549.

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Although the molecular mechanisms underlying the onset and progression of cancer has been unraveled to a great extend, cancer continues to remain a leading cause of death around the world. Clinical efficacy of the existing anticancer drugs are largely compromised by the inherent and acquired resistance of cancer cell types and the severe side effects evoked by chemotherapeutic agents. Hence, the search for novel anticancer drugs with minimum side effects remains an active area of cancer research. Although molecular targeted drugs are preferred over the conventional cytotoxic chemotherapy, the

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Valayil, Jinu Mathew. "Structure Elucidation and Biological Evaluation of a Novel Steroidal Saponin, Cholestanol Glucoside Isolated from Saraca Asoca Enodophytic Fuungus, Lasiodiplodia Theobromae." Thesis, 2015. http://etd.iisc.ernet.in/2005/3549.

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Although the molecular mechanisms underlying the onset and progression of cancer has been unraveled to a great extend, cancer continues to remain a leading cause of death around the world. Clinical efficacy of the existing anticancer drugs are largely compromised by the inherent and acquired resistance of cancer cell types and the severe side effects evoked by chemotherapeutic agents. Hence, the search for novel anticancer drugs with minimum side effects remains an active area of cancer research. Although molecular targeted drugs are preferred over the conventional cytotoxic chemotherapy, the

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