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Dissertations / Theses on the topic 'Helicobacter pylori - Molecular aspects'

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Published: 4 June 2021

Last updated: 16 February 2022

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1

Cheng, Tianfan, and 程天凡. "Structural and functional aspects of the multifaceted SlyD in Helicobacter pylori." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48199199.

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As a ubiquitous protein-folding helper in bacterial cytosol, SlyD is a peptidylprolyl isomerase (PPIase) of the FK506-binding protein (FKBP) family. It has two important functional domains, the IF (insert-in-flap) domain with chaperone activity and the FKBP domain with PPIase activity. It also possesses a histidine- and cysteine-rich C-terminal metal-binding domain, which binds to selected divalent metal ions (e.g. Ni2+, Zn2+) and is critical for participation in metal trafficking for metalloenzymes. SlyD from Helicobacter pylori was investigated both structurally and functionally by

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2

Wong, Lik-wai Benny, and 黃力偉. "Immune response and signaling mechanisms of Helicobacter pylori induced gastritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224313.

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3

Tsang, Cheuk-nam, and 曾卓南. "Mining of proteins and motifs associated with bismuth binding and monitoring metal uptake in helicobacter pylori by metallomics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46503535.

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4

Xia, Wei, and 夏炜. "The tango between two proteins: insight into the nickel delivery process exerted by HypA and HypB during [Ni, Fe]-hydrogenase maturation in helicobacter pylori." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46188666.

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5

Huang, Fung-yu, and 黃鳳如. "Pathogenetic aspects of helicobacter pylori infection in gastric cancer: a study on the role of inflammatorycytokine and gene methylation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4370363X.

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6

徐維勝 and Wei-sheng Xu. "Gastric lymphoma of MALT type: the etiologic factors and the molecular basis of pathogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31239572.

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7

Chan, On-on Annie, and 陳安安. "E-cadherin in gastric cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29974082.

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8

Kivi, Mårten. "Aspects of Helicobacter pylori transmission /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-422-8/.

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9

Houben, Martinus Henricus Maria Gerardus. "Clinical aspects in Helicobacter pylori infections." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/81155.

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10

Vallström, Anna. "Helicobacter pylori molecular mechanisms for variable adherence properties /." Umeå : Oral Microbiology, Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25931.

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11

Vallström, Anna. "Helicobacter pylori : molecular mechanisms for variable adherence properties." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25931.

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More than half of all people worldwide are infected with H. pylori. The infection always cause a gastric inflammation that may develop into peptic ulcer disease or gastric cancer. Attachment proteins, adhesins, mediate specific adherence of H. pylori to receptor structures on the human gastric mucosa. The best-characterized H. pylori adhesin-receptor interactions are the BabA adhesin and the binding to the fucosylated blood group antigens ABO/Lewis b (Leb) and the SabA adhesin and its binding to the inflammation associated sialyl-Lewis x antigen. During H. pylori infection the availability of

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12

Oona, Marje. "Helicobacter Pylori infection in children : epidemiological and therapeutic aspects /." Tartu: Tartu University Press, 2004. http://dspace.utlib.ee/dspace/bitstream/10062/1040/5/oona.pdf.

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13

Ngoyi, Esther Nina. "Résistance de Helicobacter pylori aux antibiotiques et d’autres substances antimicrobiennes. : Aspects moléculaires des mécanismes de détection." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0442/document.

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Contexte : Amélioration de la prise en charge de l’infection à H. pylori. Matériels et Méthodes : Détection de H. pylori, la résistance à la clarithromycine, la tétracycline, la lévofloxacine, et la détermination des gènes de pathogénicité ont été réalisées par PCR en temps réel, du gène de l’ARNr 23 S, de l’ARNr 16S, PCR classique et séquençage. L’évaluation de la stabilité du mutant résistant par rapport à l’isolat sensible était obtenue par compétition en culture sur cellules gastriques AGS sur une longue période, suivie du séquençage du génome entier. L’évaluation de l’effet de l’extrait d

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14

Gideonsson, Pär. "Helicobacter pylori : molecular insights into regulation of adhesion properties." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120466.

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Helicobacter pylori infects the human stomach and triggers an inflammatory response that damages the gastric tissue. This host-pathogen interplay has dire consequences as up to 20 % of infected individuals develop peptic ulcer disease or gastric cancer. Given that half of the world’s population is infected, the number of afflicted humans is staggering and also tells that H. pylori is extremely efficient in spreading and maintaining infection. To enable persistent infection many factors play a role, but one important feature of H. pylori is its impressive ability to adhere to the slimy gastric

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15

Han, Hongmei. "Molecular characterization of pyruvate ferredoxin oxidoreductase from Helicobacter pylori." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ36459.pdf.

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16

Nilsson, Christina. "Genome-plasticity and adaptation in Helicobacter pylori /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-189-X/.

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17

Rapp, Nathalie. "Gastrites chroniques et formes folliculaires associées à hélicobacter pylori : aspects histologiques et endoscopiques : étude prospective de 445 observations." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M139.

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18

Hallinger, Daniel Ross. "An Investigation of the Polymorphic arsS Gene of Helicobacter pylori." W&M ScholarWorks, 2011. https://scholarworks.wm.edu/etd/1539626912.

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19

Relvas, Sandra Maria Mota. "Influência da infecção por Helicobacter pylori nas junções apertadas." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/8844.

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Mestrado em Biologia Molecular e Celular<br>A infecção por H. pylori é uma das infecções mais prevalentes no mundo. A consequência universal da infecção por H. pylori é o desenvolvimento de gastrite crónica. A bactéria coloniza a superfície das células epiteliais gástricas, estabelecendo com estas uma relação próxima. Alguns estudos sugerem que a infecção por H. pylori induz alterações nas junções intercelulares mais próximas do pólo apical das células, ou seja, nas junções apertadas. O objectivo geral desta Tese foi o de caracterizar a expressão de proteínas das junções apertadas no c

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20

Bourzac, Kevin. "A molecular and cellular investigation of Helicobacter pylori's cag pathogenicity island and interactions with host cells /." view abstract or download file of text, 2006. http://proquest.umi.com/pqdweb?index=0&did=1251819291&SrchMode=1&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1181341914&clientId=11238.

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Thesis (Ph. D.)--University of Oregon, 2006.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 80-91). Also available for download via the World Wide Web; free to University of Oregon users.

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21

Oliveira, Telma Barbosa de. "Helicobacter pylori em pacientes com purpura trombocitopenica idiopatica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311923.

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Orientador: Sandra Cecilia Botelho Costa<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T23:14:22Z (GMT). No. of bitstreams: 1 Oliveira_TelmaBarbosade_M.pdf: 1175004 bytes, checksum: 5912fb5d3dc25609414bb097190091e2 (MD5) Previous issue date: 2008<br>Resumo: O He/icobacter pylori é uma bactéria gram-negativa que está relacionada ao desenvolvimento de doenças gástricas e extragástricas. Dentre as doenças gástricas incluem-se o câncer gástrico, a gastrite crônica, a úlcera péptica e linfoma tipo MALT. Com re

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22

Kouri, Kimberly. "Genetic characterization and molecular evolution of the cag pathogenicity island of Helicobacter pylori." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0029/MQ64384.pdf.

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23

Okwumabua, Ogi Emeke. "Biochemical and molecular characterization of urease-positive campylobacters (campylobacter pylori and campylobacter mustelae." Thesis, Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/25297.

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24

Costa, DÃbora Menezes da. "RelaÃÃo entre helicobacter pylori, metilaÃÃo gÃnica e polimorfismos genÃticos do hospedeiro no cÃncer gÃstrico." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16808.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Gastric cancer is a serious health problem. Several risk factors have been identified to contribute to its development, such as virulence genes of H. pylori, SNPs in hostâs key genes and epigenetic events. The aim of this study was to investigate the relationship between genes methylation in gastric cancer, its association with H. pylori virulence genes, and verify the influence of CDH1 and MLH1 SNPs in the methylation status and correlate methylation of the promoter of miR-34b/c expression of MET protein in those cases. The promot

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25

Ismail, H. "Application of molecular techniques to the study of Helicobacter pylori and gastric cancer." Thesis, Swansea University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637377.

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Previous research has demonstrated a link between <i>H. pylori</i> infection and gastric malignancies. The objective of the study was to investigate this correlation and evaluate detection methods for the diagnosis of this pathogen. The performance of the PCR assay for the detections of <i>H. pylori</i> in gastric tissues was assessed. The PCR assay was found to be highly sensitive for identifying the presence of <i>H. pylori</i> in gastric biopsies compared to other detection techniques such as histological examination and rapid urease test. In addition, the <i>H. pylori</i>-PCR detection met

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26

Bickley, Jane. "Development of molecular markers for studying the ecology and epidemiology of Helicobacter pylori." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386793.

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27

Jablonska, Marta. "Molecular interactions between gastric stem cells and their niche upon Helicobacter pylori infection." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21654.

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Infektionen mit H. pylori führen zu Veränderungen im Aufbau und der zellulären Zusammensetzung des Magenepithels. Aktuelle Studien haben gezeigt, dass Stromazellen, die sich in unmittelbarer Nähe der epithelialen Stammzelle befinden, die funktionelle Nische für dieses Kompartiment bilden und wichtige Faktoren für die Regulierung des Stammzellumsatzes und Differenzierung darstellen. Daher konzentriere ich mich bei dieser Arbeit auf die Rolle der Myh11+ Myofibroblasten, die sich sowohl unter als auch zwischen den Epitheldrüsenzellen befinden. Ich fand heraus, dass die Myofibroblasten in der Homö

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28

Liechti, George Warren. "Analysis of Sequence Variation at Two Helicobacter pylori Genetic Loci Potentially involved in Virulence." W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539626867.

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29

Garcia, Lobato Tavares Raquel. "Host cell responses to Helicobacter pylori secreted factors." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-148427.

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The infection of the human gastric mucosa by the bacterium Helicobacter pylori can lead to the development of gastritis, gastroduodenal ulcers, and cancer. The factors that determine disease development in a small percentage of infected individuals are still not fully understood. In this thesis, we aimed to identify and functionally characterize novel virulence factors of H. pylori and to understand their effect on host cell responses. In Paper I, we found that JHP0290, an uncharacterized secreted protein of H. pylori, induced macrophage apoptosis concomitant to the release of pro-inflammatory

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30

Rahn, Wibke. "Molecular analysis of Helicobacter pylori-associated gastric inflammation in chronically infected and immune mice." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=972341781.

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31

Pittman, Marc Stephen. "Molecular analysis of the chemotactic signal transduction system of the gastric pathogen Helicobacter pylori." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312370.

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32

Bellucci, Matteo <1982&gt. "Molecular interactions: metal ions and protein chaperones in the urease system from Helicobacter pylori." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2531/.

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Although nickel is a toxic metal for living organisms in its soluble form, its importance in many biological processes recently emerged. In this view, the investigation of the nickel-dependent enzymes urease and [NiFe]-hydrogenase, especially the mechanism of nickel insertion into their active sites, represent two intriguing case studies to understand other analogous systems and therefore to lead to a comprehension of the nickel trafficking inside the cell. Moreover, these two enzymes have been demonstrated to ensure survival and colonization of the human pathogen H. pylori, the only known mic

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33

Agriesti, Francesca <1982&gt. "Molecular architecture of fur binding to iron-induced and - repressed genes in Helicobacter pylori." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2734/.

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The ferric uptake regulator protein Fur regulates iron-dependent gene expression in bacteria. In the human pathogen Helicobacter pylori, Fur has been shown to regulate iron-induced and iron-repressed genes. Herein we investigate the molecular mechanisms that control this differential iron-responsive Fur regulation. Hydroxyl radical footprinting showed that Fur has different binding architectures, which characterize distinct operator typologies. On operators recognized with higher affinity by holo-Fur, the protein binds to a continuous AT-rich stretch of about 20 bp, displaying an extended prot

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34

Broutet, Nathalie. "Aspects épidémiologiques et diagnostiques de la gastrite chronique atrophique en Europe." Bordeaux 2, 2001. http://www.theses.fr/2001BOR28880.

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Au début des années 80, l'hypothèse de l'origine infectieuse de certains cancers et maladies chroniques inflammatoires a trouvé un regain d'intérêt quand une nouvelle bactérie, Helicobacter pylori, a été identifiée. Une dizaine d'années après, celle-ci est reconnue première bactérie cancérigène de cdlasse I par l'Agence Internationale de Recherche sur le Cancer, et causale d'autres pathologies gastriques en particulier la maladie ulcéreuse. La gastrite chronique atrophique (GCA) est une étape intermédiaire entre la gastrite chronique non atrophique, conséquence de l'infection à H. Pylori et l'

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35

Tosi, Tommaso. "Etudes structurales de facteurs de virulence de la bactérie Helicobacter pylori." Phd thesis, Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00521213.

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Helicobacter pylori est une bactérie qui infecte l'estomac de la moitié de la population mondiale et est impliquée dans la plupart des maladies gastriques, dont les ulcères et le cancer de l'estomac. La bactérie produit deux toxines, CagA et Tipα, qui sont associées avec le développement du cancer. CagA est injectée dans les cellules et interagit avec de nombreuses protéines des voies de signalisation cellulaire. Tipα est secrétée et internalisée dans les cellules gastriques où elle induit la production de cytokines pro-inflammatoires. Dans ce travail de thèse, nous avons tout d'abord étudié l

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36

Jablonska, Marta [Verfasser]. "Molecular interactions between gastric stem cells and their niche upon Helicobacter pylori infection / Marta Jablonska." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1216876916/34.

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37

Jiménez, Soto Luisa Fernanda [Verfasser]. "Molecular studies on Helicobacter pylori and the conditions for its toxicity / Luisa Fernanda Jiménez Soto." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/118222878X/34.

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38

Dube, Callote. "Prevalence and risk factors for Helicobacter pylori transmission in the Eastern Cape Province application of immunological molecular and demographic methods." Thesis, University of Fort Hare, 2010. http://hdl.handle.net/10353/265.

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Helicobacter pylori (H. pylori) is a microaerophilic, Gram-negative motile curved rod that inhabits the gastric mucosa of the human stomach. The organism chronically infects billions of people worldwide and is one of the most genetically diverse of bacterial species. Infection with the organism potentially induces chronic gastritis and peptic ulcer disease. In addition, H. pylori plays a role in the etiology of gastric cancer and gastric MALT lymphoma. The risk of infection is increased in those living in the developing world, which has been ascribed to precarious hygiene standards, crowded ho

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39

Solange, Evans Osses Ingrid. "Desenvolvimento e otimização de métodos de biolgia molecular para o diagnóstico de Leichmania chagasi e Helicobacter pylori." Universidade Federal de Pernambuco, 2006. https://repositorio.ufpe.br/handle/123456789/2080.

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Made available in DSpace on 2014-06-12T15:54:26Z (GMT). No. of bitstreams: 2 arquivo5232_1.pdf: 6314022 bytes, checksum: 6d483dcd851885e89a9ca20a1e572b4a (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2006<br>Neste trabalho foram desenvolvidos e otimizados métodos diagnósticos para dois agentes patogênicos com uma alta incidência no Brasil e cujos diagnósticos se baseiam principalmente em métodos invasivos como são o Helicobacter pylori e Leishmania chagasi (L. chagasi). A bactéria gram (-) Helicobacter pylori e a principal causa de ulcer

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40

Huang, Fung-yu. "Pathogenetic aspects of helicobacter pylori infection in gastric cancer : a study on the role of inflammatory cytokine and gene methylation /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B4370363X.

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41

Xu, Wei-sheng. "Gastric lymphoma of MALT type : the etiologic factors and the molecular basis of pathogenesis /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20793133.

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42

Huesca, Contreras Mario. "Molecular characterization of the mechanisms of adhesion of Helicobacter pylori, a model of environmental regulation of bacterial attachment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41025.pdf.

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43

MIRANDA, Ariney Costa de. "Estudo do perfil de pacientes submetidos a pesquisa de Helicobacter pylori: análise endoscópica e dos fatores determinantes da atividade linfocitária na resposta imunológica gástrica (ROR-Y, FOXP3 e GATA3)." Universidade Federal do Pará, 2015. http://repositorio.ufpa.br/jspui/handle/2011/9114.

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Ge, Ruiguang. "A biochemical and proteomic view of nickel homeostasis and bismuth treatment : identification of bismuth-targeted proteins in Helicobacter pylori and characterization of a nickel-storage protein hpn /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36761084.

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45

Pereira, Eliane dos Santos. "Helicobacter pylori - importÃncia dos genes da ilha e de adesÃo no cÃncer gÃstrico (Intestinal e Difuso) e em estudos de risco." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15416.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>O cÃncer gÃstrico (CG) Ã a terceira causa de morte por cÃncer no mundo. A etiologia do CG Ã multifatorial sendo bem estabelecida a associaÃÃo com a infecÃÃo por Helicobacter pylori. A susceptibilidade genÃtica ao CG Ã postulado pela exposiÃÃo de uma grande proporÃÃo da populaÃÃo a fatores de risco, mas somente um grupo desenvolve essa neoplasia. Por outro lado, o carÃter patogÃnico de H. pylori Ã dado pela presenÃa da ilha de patogenicidade cag-PAI (cytotoxin associated gene pathogenicity island - cagPAI) bem como a variaÃÃo alÃlic

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46

Botham, Crystal Marie. "Molecular and genetic dissection of host pathways disrupted by Helicobacter pylori's virulence factor, cytotoxin associated gene A /." view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1417800931&sid=1&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2007.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 60-66). Also available for download via the World Wide Web; free to University of Oregon users.

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47

Martins, Gustavo Miranda. "Detecção molecular de resistência do Helicobacter pylori à claritromicina e fluorquinolonas, diretamente a partir de biópsias gástricas, em Belo Horizonte." Universidade Federal de Minas Gerais, 2014. http://hdl.handle.net/1843/BUBD-9VZJMH.

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INTRODUÇÃO: A resistência aos antimicrobianos é o principal fator associado à falha terapêutica no tratamento do H. pylori. Testes moleculares são úteis na detecção das mutações genéticas associadas ao desenvolvimento de resistência à claritromicina e fluorquinolonas. O conhecimento da taxa de prevalência local de resistência é importante na definição do melhor esquema terapêutico. OBJETIVOS: Estimar a prevalência de resistência primária do H. pylori à claritromicina e fluorquinolonas, empregando-se um teste molecular, em Belo Horizonte. MÉTODOS: Setenta e dois pacientes com sorologia positi

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Gómez, Martínez Julián. "Caracterización molecular de cepas de "Helicobacter pylori". Reproducción del modelo animal en ratones y estudio de los mecanismos de la inflamación." Doctoral thesis, Universitat de Barcelona, 2001. http://hdl.handle.net/10803/2414.

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A raíz del descubrimiento de "Helicobacter pylori", hemos asistido a una revolución en la práctica de la medicina. Las consecuencias de esta infección son enfermedades como úlcera péptica, gastritis crónica, adenocarcinoma gástrico y linfoma tipo MALT. El carácter crónico, así como la elevada incidencia de la infección, han despertado en los últimos años un gran interés científico.

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Wang, Minji, and 汪旻稷. "Crystallographic studies of Helicobacter pylori chaperone HspB and human serum transferrin : metalloprotein as a template for heavy metal ions and their relevance to bismuth antiulcer drug." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208592.

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Iron is important for human health and serves as a co-factor in a variety of proteins and enzymes. Human serum transferrin (hTF) is an Fe(III) transporter in blood plasma which delivers metal to cells via a receptor-mediated endocytosis. In the first part, crystal structures of FeNFeC-hTF and BiNFeC-hTF have been characterized. The N-lobes of the two structures adopt “partially opened” conformations between holo-hTF’s “closed” and apo-hTF’s “fully-opened” states. The N-lobe of BiNFeC-hTF opens wider than FeNFeC-hTF. Their metal-bound C-lobes are totally closed. Rigid-body movement and diffe

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Holokai, Loryn. "Organoid Models of Digestive Diseases." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563437019338307.

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