Relevant bibliographies by topics / Helleborus niger

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Academic literature on the topic 'Helleborus niger'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Helleborus niger"

1

Unseld, Erich. "Helleborus niger." Allgemeine Homöopathische Zeitung 214, no. 02 (April 13, 2007): 49–57. http://dx.doi.org/10.1055/s-2006-935496.

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Höggemeier, Annette, and Armin Jagel. "Christrose – Helleborus niger." Der Palmengarten 72, no. 2 (May 28, 2018): 164–65. http://dx.doi.org/10.21248/palmengarten.364.

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Seyring, M. "In vitro cloning of Helleborus niger." Plant Cell Reports 20, no. 10 (March 2002): 895–900. http://dx.doi.org/10.1007/s00299-001-0420-1.

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4

Jesse, Patrick, Gritt Mottke, Georg Seifert, Simone Fulda, Guenter Henze, and Aram Prokop. "Apoptosis Induced by Extracts of Helleborus Niger in Different Lymphoma and Leukemia Cell Lines and Primary Lymphoblasts of Children with ALL Is Independent of Smac-Overexpression and Executed Via the Mitochondrial Pathway." Blood 110, no. 11 (November 16, 2007): 4215. http://dx.doi.org/10.1182/blood.v110.11.4215.4215.

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Abstract Helleborus niger, also known as Christmas Rose, belongs to the family of Ranunculaceae, a family of flowering plants with about 2500 different species. In complementary medicine Helleborus niger is used as adjuvant drug in the treatment of non-metastasised and metastasised forms of bronchial cancer, abdominal tumours and prostate cancer. It is also applied in myeloproliferative diseases like Hodgkin and Non-Hodgkin lymphoma, leukaemic disorders and AIDS- related diseases like the Kaposi sarcoma. Until now, there is no clinical or preclinical data regarding the effects of Helleborus niger in vivo, ex vivo or in vitro. For this purpose, we investigated the cytotoxic effects of four different standardized aqueous Helleborus niger extracts from the companies Hiscia and Helixor on various cancer cell lines. We used one whole plant extract, one root extract, one leave extract and one containing only the blossom of Helleborus niger. After 4h of treatment with the extracts no significant LDH release was measured, thus excluding an unspecific, necrotic damage of the cell membrane. After 24h a dose dependent inhibition of proliferation up to 69% could be found and after 48h a distinction into early (45,2%) and late apoptotic (45,5%) cells was detected via Annexin/PI staining. The cell cycle analysis revealed characteristic hypodiploid DNA fragments after 72h, once more identifying apoptosis as cause of the cell death. In the Western Blot analysis a processing of Caspase-3 could be found after 36 h incubation with the extract. Apoptotic cell death was detected in the Burkitt-like lymphoma cell line BJAB, the three human acute lymphoblastic leukemia cell lines NALM-6, Sup-B-15 and REH and the melanoma cell line MEL-HO. The apoptosis induction caused by the root extract was higher than the apoptotic cell death in the other extracts. There are two major pathways of apoptosis, the extrinsic pathway via death receptors like FADD and the intrinsic pathway via the mitochondria. In BJAB cells a breakdown of the mitochondrial membrane potential and dose-dependent mitochondrial permeability transition was detected after 48h, revealing that apoptosis is executed via the mitochondrial pathway. Furthermore, we found a decreased apoptosis induction in BCL-2 overexpressing melanoma cells. The dependency of Bcl-2 expression is another sign of apoptosis via the mitochondrial pathway. In contrast, apoptosis induction by Helleborus niger seems to be independent of Smac overexpression, which could be shown in Jurkat cells. In combination with the vinca alkaloid vincristine, which is used in the treatment of ALL, a synergistic effect could be detected. The apoptosis induction was up to 16% higher in combination than in the single treatment. Finally, we evaluated the effect on primary leukemia cells ex vivo. Interestingly, we could show a significant apoptosis induction in primary leukemia cells from 2 patients with ALL or AML in childhood, which were resistant to the treatment with the anthracycline doxorubicin. For the first time, we were able to show that extracts of Helleborus niger induce apoptosis in different cancer cell lines and primary leukemia cells. Apoptosis is executed via the intrinsic pathway and is independent of Smac overexpression. Thus, we present an interesting baseline for the design of upcoming in vivo experiments or clinical trials.
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Mendes, Maria Filomena Xavier, Romeu Carillo Junior, Domingos José Vaz Cabo, Maria Solange Gosik, Renata Rodrigues Garcia Lino, Raquel Bruno Kalile, Davisson Tavares, et al. "Research protocol for homeopathic treatment of congenital zika virus infection." International Journal of High Dilution Research - ISSN 1982-6206 18, no. 02 (June 30, 2021): 16–17. http://dx.doi.org/10.51910/ijhdr.v18i02.995.

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Background The Zika virus (ZIKV) is a flavivirus and the human disease caused by this virus has been described in the Americas in 2015. ZIKV has been identified as an etiological agent of acute exanthematous disease in Brazil. In the same year, an epidemic of microcephaly with images suggestive of congenital infection raised the suspicion of a relationship between these alterations and ZIKV infection. Epidemiological and histopathological studies point to a strong relationship between prenatal Zika virus infection and microcephaly. Newborns with microcephaly, may also present auditory and visual changes, seizures and severe neurodevelopmental impairment. In 2016, the World Health Organization (WHO) declared Zika virus (ZIKV) infection a public health emergency of international concern. Aims Clinical observation in the ambulatory school of ABRAH (Brazilian Association of Recycling and Homeopathy Assistance) of patients with encephalopathy of various origins, using the medicine Helleborus niger as equalizer of the NS (Nervous System), as described in the Complex Systems of Carillo, shows improvement in motor, cognitive and seizure disorders. Based on this observation, we propose to use this method in patients with ZIKV congenital infection. Methodology To evaluate 15 patients in follow-up at the AFR (Fluminense Rehabilitation Association), through homeopathic anamnesis, clinical, diathesic, biotypological and temperamental classification. The Gross Motor Function Classification System (GMFCS) will be used. All patients will receive Helleborus niger 6 Ch daily for 6 months. Results and discussion This study was forwarded to the research ethics committee and will begin in July 2019. Will be evaluated the use of Helleborus niger in patients with congenital infection by ZIKV, as equalizer of NS. The expected result is overall neurological improvement. Conclusion Helleborus niger, probably stimulating self-regulation through uninjured neurological pathways, will promote autopoiesis and construction of new programs of action, and will enable the improvement of patients with congenital ZIKV infection.
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Lockhart, Sharon J., and Mary Lewnes Albrecht. "Notes on Germination of Helleborus niger L. (Ranunculaceae)." Transactions of the Kansas Academy of Science (1903-) 90, no. 3/4 (October 1987): 96. http://dx.doi.org/10.2307/3627789.

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Schmitzer, Valentina, Maja Mikulic-Petkovsek, and Franci Stampar. "Sepal phenolic profile during Helleborus niger flower development." Journal of Plant Physiology 170, no. 16 (November 2013): 1407–15. http://dx.doi.org/10.1016/j.jplph.2013.05.012.

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Lowder, Adam W., Helen T. Kraus, Frank A. Blazich, and Stuart L. Warren. "Day/Night Temperatures Influence Growth and Photosynthesis During Containerized Production of Selected Species of Helleborus (Hellebores)." Journal of Environmental Horticulture 28, no. 3 (September 1, 2010): 179–86. http://dx.doi.org/10.24266/0738-2898-28.3.179.

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Abstract Containerized seedlings of Helleborus foetidus L. (stinking hellebore), H. niger L. (Christmas rose), and H. ×hybridus L. (Lenten rose) were grown under long-day conditions in controlled-environment chambers for 95 days with 9-hr days of 14, 18, 22, 26, or 30C (57, 64, 72, 79, or 86F) in factorial combination with 15-hr nights of 10, 14, 18, 22, or 26C (50, 57, 64, 72, or 79F). Long-day conditions were provided by a 3-hr night interruption. Growth of each species responded differently to day and night temperatures. Calculated maximum root, top, and total dry weight, and leaf area of H. foetidus occurred with days/nights of 20/15, 18/13, 19/14, and 18/15C (68/59, 65/55, 66/57, and 65/59F), respectively. While night temperature (NT) had no effect on root:top ratio [RTR (root dry weight ÷ top dry weight)], RTR was greatest (0.65) with days of 22C (72F). Helleborus niger had calculated maximum root dry weight and total dry weight with days of 14C (57F) and nights of 16 and 13C (60 and 55F), respectively. Top growth of H. niger decreased linearly as NTs increased for days of 14 or 22C (57 or 72F). Day temperatures (DTs) had no effect on RTR, whereas RTR responded quadratically as NT increased with a calculated maximum RTR at nights of 19C (66F). Leaf area was maximized at days/nights of 14/10C (57/50F). At days of 22 or 26C (72 or 79F), top growth of H. ×hybridus responded quadratically as NT increased with maxima occurring at nights of 18 or 17C (64 or 63F). Root dry weight responded quadratically at days of 14, 22, or 26C (57, 72, or 79F) and calculated maxima occurred with nights of 18C (64F). At days of 22 or 26C (72 or 79F), there were quadratic responses in total dry weight with calculated maximum growth of H. ×hybridus at nights of 18 or 17C (64 or 63F), respectively. For days of 14, 22, or 30C (57, 72, or 86F), there were quadratic responses in RTR with greatest RTR calculated at nights of 15, 18, or 16C (59, 64, or 60F), respectively. There were quadratic responses at days of 22 or 26C (72 or 79F) for leaf area with calculated maxima at nights of 18 or 17C (64 or 63F), respectively. As DTs increased from 14 to 30C (57 to 86F) net CO2 assimilation (PN) of H. ×hybridus also increased linearly whereas increased NTs had no effect on PN. In contrast, stomatal conductance was not impacted by DT or NT.
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Lalitha, KG, and VKishor Kumar. "Pharmacognostical and phytochemical studies of Helleborus niger L root." Ancient Science of Life 36, no. 3 (2017): 151. http://dx.doi.org/10.4103/asl.asl_57_16.

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Šušek, Andrej. "Perspectives of Christmas rose (Helleborus niger L.) genetic improvement." Agricultura 13, no. 1-2 (December 1, 2016): 11–19. http://dx.doi.org/10.1515/agricultura-2017-0003.

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Abstract The Christmas rose is becoming a very important ornamental plant on the market. It is relatively new to intensive production technologies. The number of genetically-improved varieties on the market is limited, and many of the old cultivars are no longer available because of slow and economically unfeasible vegetative propagation. In the future, its genetic improvement will probably become inevitable. New cultivars will have to satisfy the specific requirements of the market and producers as well as strict environmental policy. In order to obtain new cultivars it will be necessary to evaluate the existing germplasm and apply an adequate genetic breeding approach. There are seven main possibilities of creating new varieties: the use of natural variation associated with seed germination, population approach based on recurrent selection, individual selection based on specific genetic combinations, the creation of inbred lines and the formation of hybrids, interspecific hybridisation, mutagenesis and genetic engineering. Molecular markers can be very helpful during the breeding process. They can be used in order to study genetic relationships amongst populations, ecotypes, varieties, and hybrids.
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Dissertations / Theses on the topic "Helleborus niger"

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Sušek, Andrej. "Analyse de la diversité de populations naturelles de Helleborus niger L." Dijon, 2007. http://www.theses.fr/2007DIJOS042.

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Le travail de thèse a été réalisé sur la rose de Noël (Helleborus niger L. ) à partir de populations issues de milieux naturels (sept en Slovénie et une en Croatie). L'objectif principal de la thèse était d'étudier les variations morphologiques. L'approche phénotypique a consisté à mesurer 18 traits (moyenne, extrême, corrélation et analyse discriminante). Certains traits se sont révélés très variables (nombre de feuilles par plante, nombre d'inflorescences par plante). La gamme de variation observée s'est avérée plus importante que celle mentionnée dans la littérature. L'analyse de corrélation a mis en évidence qu'il y avait plusieurs traits liés. La variabilité serait plus importante au sein des populations étudiées qu'entre elles. L'approche moléculaire (AFLP) a été employée pour étudier la variabilité génétique entre et parmi trois de ces populations. Les individus de chacune de ces populations sont dispersés le long du dendrogramme ; ils ne peuvent pas constituer des groupes distincts sur une base génétique. L'analyse du système de reproduction suggère que la rose de Noël soit une espèce principalement allogame à pollinisation entomophile. Les analyses phénotypiques et moléculaires indiquent donc que les populations étudiées ne sont pas géographiquement isolées. Connaissant les exigences du marché, les populations les plus intéressantes sont celles de Žumberak (Croatie), avec les plus longs pédoncules et les fleurs les plus larges, et celle de Peca, avec le nombre le plus élevé d'inflorescences par plante. Les populations roses de Noël slovène et croate peuvent être considérées comme source très intéressante pour la création variétale
Research work involved Christmas rose (Helleborus niger L. ) plant material from naturally grown local populations: seven in Slovenia and one in Croatia. The main objective of the research was to evaluate the morphological variations. The evaluation involved the recording of 18 traits (averages, extremes, correlations and discriminant analysis). Some of the traits showed a relatively high level of variation (number of leaves per plant, number of inflorescences per plant). The variation ranges for some traits were found to be wider than those mentioned in the literature. The correlation analysis indicated that there were several related traits. The variability within populations was more expressed that between populations. The molecular marker approach (AFLP) was used to study the genetic variation between and within three populations. The analysis showed that individuals from all three populations appeared scattered along the resulting dendrogram and that they could not be separated into distinct groups on a genetic basis. The analysis of the pollination system suggests that the Christmas rose could be a predominantly cross-pollinating species. The phenotypic and molecular analyses indicate that the populations investigated were not geographically isolated. Regarding the market preferences, the populations with the most valuable plant material are the Žumberak population (Croatia), containing genotyps with the longest peduncles and the largest flowers, and the Peca population, with the highest number of inflorescences per plant. The Slovenian and Croatian Christmas rose populations can be considered as a higly valuable source of genes for genetic breeding
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2

Duckstein, Sarina M. [Verfasser]. "Hamamelis virginiana L. and Helleborus niger L. – Characterization of their genuine constituent profiles and fermented extracts by high-performance liquid chromatography-tandem mass spectrometry (LC-MSn) / Sarina M. Duckstein." Aachen : Shaker, 2014. http://d-nb.info/1066198128/34.

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Jesse, Patrick [Verfasser]. "Präklinische Evaluation pflanzlicher Extrakte aus Helleborus niger und Viscum album L. sowie eines Gold(I)- Phosphinkomplexes mit funktionellem Naphthalimidliganden bezüglich ihrer Apoptose- induzierenden Wirksamkeit und den dabei zugrunde liegenden Mechanismen in vitro, ex vivo und in vivo / Patrick Jesse." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024743489/34.

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Shabangu, Nondumiso. "The efficacy of a homoeopathic complex (Nux moschata D6, Phosphoricum acidum D30, Helleborus niger D6, Opium D30) in management of excessive daytime sleepiness." Thesis, 2018. http://hdl.handle.net/10321/3050.

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Submitted in partial compliance with the requirements of the Master’s Degree in Technology: Homoeopathy, Durban University of Technology, Durban, South Africa, 2018.
Background : Excessive daytime sleepiness (EDS) is the inclination or compulsion to fall asleep whilst intending to stay awake; it is believed to negatively affect occupational and social functioning and may be a predisposition towards accidents (Hayley et al. 2014), low productivity and interpersonal problems (Fong et al. 2005). Excessive daytime sleepiness is one of the most common sleep-related symptoms and it affects an estimated 20% of the population (Pagel .2009). The causes of EDS are numerous and include intrinsic sleep disorders (e.g. narcolepsy, obstructive apnoea/ hypopnea syndrome, idiopathic hypersomnia), and extrinsic disorders (Banerjee et al. 2004). Sleep deprivation is probably the most common cause of excessive daytime sleepiness. This clinic trial intended to evaluate the effectiveness of a homoeopathic complex (Nux moschata D6, Phosphoricum acidum D30, Helliborus niger D6, Opium D30) in the management of EDS in terms of the Epworth Sleepiness Scale (Johns, 1991) and Stanford Sleepiness Scale (Hoddes et al. 1973). And this randomised, double-blind placebo controlled study also aimed to provide a safe and effective alternative therapy for EDS. Aim of the study : The objective of this study was to determine the efficacy of a homoeopathic complex (Nux moschata D6, Phosphoricum acidum D30, Helliborus niger D6, Opium D30) and placebo in the management of EDS in terms of the Epworth Sleepiness Scale (ESS) and the Stanford Sleepiness Scale (SSS). Materials and Methodology : A sample group of 35 participants was selected voluntarily to conduct the study on basis of the inclusion and exclusion criteria. The participants were than randomly divided into two groups; a treatment group consisting of 23 participants and a placebo group consisting of 12 participants. Each participant had to attend three consultations in total with the researcher over a period of four weeks at the Durban University of Technology (DUT) Homoeopathic Day Clinic. At the first consultation a comprehensive case history (appendix F) was taken and physical examination (appendix E) was performed by the researcher but no medication was handed at that point. At each consultation the participants with the help of the researcher completed the Epworth Sleepiness Scale (ESS), and the seven days’ baseline Stanford Sleepiness Scale (SSS) was handed to the participants at the first and second consultation which the participants completed without the help of the researcher throughout the trial till their last consultation. Results : Results from the two measuring tools were statistically analysed with SPSS version 24.0. the participant’s level of sleepiness improved in both the treatment group and the placebo group. Intra-group analyses of ESS means revealed that both groups improved significantly over time, intergroup ANOVA analysis however revealed no significant differences between the groups. Section analyses however using the Fisher’s Exact Tests did reveal statistically significant differences within certain variables at some points of the study. Intra-group analyses of SSS data revealed no statistically significant change in SSS scores over the three weeks in both the Homoeopathic Complex and the Placebo Groups, as well as the Inter-group Fischer’s Exact tests revealed no statistically significant differences between the groups. Conclusion : Barring a few exceptions described in Chapter 4 & 5 it can be concluded from the results of the study that statistically the Homoeopathic complex (Nux moschata D6, Phosphoricum acidum D30, Helliborus niger D6, Opium D30) was not superior to placebo in the treatment of EDS. The data shows that both the Homoeopathic Complex and the placebo interventions had a positive effect on EDS and were effective in improving the level of excessive daytime Sleepiness. Irrespective of the general lack of statistical significance between groups a closer analysis of the intragroup and inter-group data does reveal a trend suggesting clinical significance in support of the effectiveness of the homoeopathic complex in the treatment of EDS however this needs to be further explored and confirmed in subsequent studies.
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Book chapters on the topic "Helleborus niger"

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Helleborus niger L." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 672. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2224.

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Khare, C. P. "Helleborus niger Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_737.

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Akbar, Shahid. "Helleborus niger L. (Ranunculaceae)." In Handbook of 200 Medicinal Plants, 991–95. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-16807-0_105.

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Nash, Eugene B., and Rainer Wilbrand. "Helleborus niger." In Leitsymptome in der homöopathischen Therapie. Stuttgart: Georg Thieme Verlag, 2015. http://dx.doi.org/10.1055/b-0036-138610.

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Kupper, Jacqueline, and Daniel Demuth. "Helleborus niger (Christrose)." In Giftige Pflanzen für Klein- und Heimtiere. Stuttgart: Enke Verlag, 2010. http://dx.doi.org/10.1055/b-0038-150324.

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