Journal articles: 'Helleborus niger'

1

Unseld, Erich. "Helleborus niger." Allgemeine Homöopathische Zeitung 214, no. 02 (April 13, 2007): 49–57. http://dx.doi.org/10.1055/s-2006-935496.

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Höggemeier, Annette, and Armin Jagel. "Christrose – Helleborus niger." Der Palmengarten 72, no. 2 (May 28, 2018): 164–65. http://dx.doi.org/10.21248/palmengarten.364.

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Seyring, M. "In vitro cloning of Helleborus niger." Plant Cell Reports 20, no. 10 (March 2002): 895–900. http://dx.doi.org/10.1007/s00299-001-0420-1.

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4

Jesse, Patrick, Gritt Mottke, Georg Seifert, Simone Fulda, Guenter Henze, and Aram Prokop. "Apoptosis Induced by Extracts of Helleborus Niger in Different Lymphoma and Leukemia Cell Lines and Primary Lymphoblasts of Children with ALL Is Independent of Smac-Overexpression and Executed Via the Mitochondrial Pathway." Blood 110, no. 11 (November 16, 2007): 4215. http://dx.doi.org/10.1182/blood.v110.11.4215.4215.

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Abstract Helleborus niger, also known as Christmas Rose, belongs to the family of Ranunculaceae, a family of flowering plants with about 2500 different species. In complementary medicine Helleborus niger is used as adjuvant drug in the treatment of non-metastasised and metastasised forms of bronchial cancer, abdominal tumours and prostate cancer. It is also applied in myeloproliferative diseases like Hodgkin and Non-Hodgkin lymphoma, leukaemic disorders and AIDS- related diseases like the Kaposi sarcoma. Until now, there is no clinical or preclinical data regarding the effects of Helleborus niger in vivo, ex vivo or in vitro. For this purpose, we investigated the cytotoxic effects of four different standardized aqueous Helleborus niger extracts from the companies Hiscia and Helixor on various cancer cell lines. We used one whole plant extract, one root extract, one leave extract and one containing only the blossom of Helleborus niger. After 4h of treatment with the extracts no significant LDH release was measured, thus excluding an unspecific, necrotic damage of the cell membrane. After 24h a dose dependent inhibition of proliferation up to 69% could be found and after 48h a distinction into early (45,2%) and late apoptotic (45,5%) cells was detected via Annexin/PI staining. The cell cycle analysis revealed characteristic hypodiploid DNA fragments after 72h, once more identifying apoptosis as cause of the cell death. In the Western Blot analysis a processing of Caspase-3 could be found after 36 h incubation with the extract. Apoptotic cell death was detected in the Burkitt-like lymphoma cell line BJAB, the three human acute lymphoblastic leukemia cell lines NALM-6, Sup-B-15 and REH and the melanoma cell line MEL-HO. The apoptosis induction caused by the root extract was higher than the apoptotic cell death in the other extracts. There are two major pathways of apoptosis, the extrinsic pathway via death receptors like FADD and the intrinsic pathway via the mitochondria. In BJAB cells a breakdown of the mitochondrial membrane potential and dose-dependent mitochondrial permeability transition was detected after 48h, revealing that apoptosis is executed via the mitochondrial pathway. Furthermore, we found a decreased apoptosis induction in BCL-2 overexpressing melanoma cells. The dependency of Bcl-2 expression is another sign of apoptosis via the mitochondrial pathway. In contrast, apoptosis induction by Helleborus niger seems to be independent of Smac overexpression, which could be shown in Jurkat cells. In combination with the vinca alkaloid vincristine, which is used in the treatment of ALL, a synergistic effect could be detected. The apoptosis induction was up to 16% higher in combination than in the single treatment. Finally, we evaluated the effect on primary leukemia cells ex vivo. Interestingly, we could show a significant apoptosis induction in primary leukemia cells from 2 patients with ALL or AML in childhood, which were resistant to the treatment with the anthracycline doxorubicin. For the first time, we were able to show that extracts of Helleborus niger induce apoptosis in different cancer cell lines and primary leukemia cells. Apoptosis is executed via the intrinsic pathway and is independent of Smac overexpression. Thus, we present an interesting baseline for the design of upcoming in vivo experiments or clinical trials.

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Mendes, Maria Filomena Xavier, Romeu Carillo Junior, Domingos José Vaz Cabo, Maria Solange Gosik, Renata Rodrigues Garcia Lino, Raquel Bruno Kalile, Davisson Tavares, et al. "Research protocol for homeopathic treatment of congenital zika virus infection." International Journal of High Dilution Research - ISSN 1982-6206 18, no. 02 (June 30, 2021): 16–17. http://dx.doi.org/10.51910/ijhdr.v18i02.995.

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Background The Zika virus (ZIKV) is a flavivirus and the human disease caused by this virus has been described in the Americas in 2015. ZIKV has been identified as an etiological agent of acute exanthematous disease in Brazil. In the same year, an epidemic of microcephaly with images suggestive of congenital infection raised the suspicion of a relationship between these alterations and ZIKV infection. Epidemiological and histopathological studies point to a strong relationship between prenatal Zika virus infection and microcephaly. Newborns with microcephaly, may also present auditory and visual changes, seizures and severe neurodevelopmental impairment. In 2016, the World Health Organization (WHO) declared Zika virus (ZIKV) infection a public health emergency of international concern. Aims Clinical observation in the ambulatory school of ABRAH (Brazilian Association of Recycling and Homeopathy Assistance) of patients with encephalopathy of various origins, using the medicine Helleborus niger as equalizer of the NS (Nervous System), as described in the Complex Systems of Carillo, shows improvement in motor, cognitive and seizure disorders. Based on this observation, we propose to use this method in patients with ZIKV congenital infection. Methodology To evaluate 15 patients in follow-up at the AFR (Fluminense Rehabilitation Association), through homeopathic anamnesis, clinical, diathesic, biotypological and temperamental classification. The Gross Motor Function Classification System (GMFCS) will be used. All patients will receive Helleborus niger 6 Ch daily for 6 months. Results and discussion This study was forwarded to the research ethics committee and will begin in July 2019. Will be evaluated the use of Helleborus niger in patients with congenital infection by ZIKV, as equalizer of NS. The expected result is overall neurological improvement. Conclusion Helleborus niger, probably stimulating self-regulation through uninjured neurological pathways, will promote autopoiesis and construction of new programs of action, and will enable the improvement of patients with congenital ZIKV infection.

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Lockhart, Sharon J., and Mary Lewnes Albrecht. "Notes on Germination of Helleborus niger L. (Ranunculaceae)." Transactions of the Kansas Academy of Science (1903-) 90, no. 3/4 (October 1987): 96. http://dx.doi.org/10.2307/3627789.

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Schmitzer, Valentina, Maja Mikulic-Petkovsek, and Franci Stampar. "Sepal phenolic profile during Helleborus niger flower development." Journal of Plant Physiology 170, no. 16 (November 2013): 1407–15. http://dx.doi.org/10.1016/j.jplph.2013.05.012.

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8

Lowder, Adam W., Helen T. Kraus, Frank A. Blazich, and Stuart L. Warren. "Day/Night Temperatures Influence Growth and Photosynthesis During Containerized Production of Selected Species of Helleborus (Hellebores)." Journal of Environmental Horticulture 28, no. 3 (September 1, 2010): 179–86. http://dx.doi.org/10.24266/0738-2898-28.3.179.

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Abstract Containerized seedlings of Helleborus foetidus L. (stinking hellebore), H. niger L. (Christmas rose), and H. ×hybridus L. (Lenten rose) were grown under long-day conditions in controlled-environment chambers for 95 days with 9-hr days of 14, 18, 22, 26, or 30C (57, 64, 72, 79, or 86F) in factorial combination with 15-hr nights of 10, 14, 18, 22, or 26C (50, 57, 64, 72, or 79F). Long-day conditions were provided by a 3-hr night interruption. Growth of each species responded differently to day and night temperatures. Calculated maximum root, top, and total dry weight, and leaf area of H. foetidus occurred with days/nights of 20/15, 18/13, 19/14, and 18/15C (68/59, 65/55, 66/57, and 65/59F), respectively. While night temperature (NT) had no effect on root:top ratio [RTR (root dry weight ÷ top dry weight)], RTR was greatest (0.65) with days of 22C (72F). Helleborus niger had calculated maximum root dry weight and total dry weight with days of 14C (57F) and nights of 16 and 13C (60 and 55F), respectively. Top growth of H. niger decreased linearly as NTs increased for days of 14 or 22C (57 or 72F). Day temperatures (DTs) had no effect on RTR, whereas RTR responded quadratically as NT increased with a calculated maximum RTR at nights of 19C (66F). Leaf area was maximized at days/nights of 14/10C (57/50F). At days of 22 or 26C (72 or 79F), top growth of H. ×hybridus responded quadratically as NT increased with maxima occurring at nights of 18 or 17C (64 or 63F). Root dry weight responded quadratically at days of 14, 22, or 26C (57, 72, or 79F) and calculated maxima occurred with nights of 18C (64F). At days of 22 or 26C (72 or 79F), there were quadratic responses in total dry weight with calculated maximum growth of H. ×hybridus at nights of 18 or 17C (64 or 63F), respectively. For days of 14, 22, or 30C (57, 72, or 86F), there were quadratic responses in RTR with greatest RTR calculated at nights of 15, 18, or 16C (59, 64, or 60F), respectively. There were quadratic responses at days of 22 or 26C (72 or 79F) for leaf area with calculated maxima at nights of 18 or 17C (64 or 63F), respectively. As DTs increased from 14 to 30C (57 to 86F) net CO2 assimilation (PN) of H. ×hybridus also increased linearly whereas increased NTs had no effect on PN. In contrast, stomatal conductance was not impacted by DT or NT.

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9

Lalitha, KG, and VKishor Kumar. "Pharmacognostical and phytochemical studies of Helleborus niger L root." Ancient Science of Life 36, no. 3 (2017): 151. http://dx.doi.org/10.4103/asl.asl_57_16.

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10

Šušek, Andrej. "Perspectives of Christmas rose (Helleborus niger L.) genetic improvement." Agricultura 13, no. 1-2 (December 1, 2016): 11–19. http://dx.doi.org/10.1515/agricultura-2017-0003.

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Abstract The Christmas rose is becoming a very important ornamental plant on the market. It is relatively new to intensive production technologies. The number of genetically-improved varieties on the market is limited, and many of the old cultivars are no longer available because of slow and economically unfeasible vegetative propagation. In the future, its genetic improvement will probably become inevitable. New cultivars will have to satisfy the specific requirements of the market and producers as well as strict environmental policy. In order to obtain new cultivars it will be necessary to evaluate the existing germplasm and apply an adequate genetic breeding approach. There are seven main possibilities of creating new varieties: the use of natural variation associated with seed germination, population approach based on recurrent selection, individual selection based on specific genetic combinations, the creation of inbred lines and the formation of hybrids, interspecific hybridisation, mutagenesis and genetic engineering. Molecular markers can be very helpful during the breeding process. They can be used in order to study genetic relationships amongst populations, ecotypes, varieties, and hybrids.

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11

Slavík, Jiří, Jitka Bochořáková, and Leonora Slavíková. "Occurrence of magnoflorine and corytuberine in some wild or cultivated plants of Czechoslovakia." Collection of Czechoslovak Chemical Communications 52, no. 3 (1987): 804–12. http://dx.doi.org/10.1135/cccc19870804.

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Magnoflorine was isolated for the first time from Adonis vernalis L., Clematis recta L., and Epimedium versicolor MORR., further also from Aquilegia sp., Caltha palustris L., Isopyrum thalictroides L., and Aristolochia clematitis L. It was detected in Adonis aestivalis L., Clematis vitalba L., Consolida regalis GRAY, and Helleborus viridis L. Corytuberine was isolated for the first time from Caltha palustris L. and detected in small amounts in Adonis vernalis, A. aestivalis, Aquilegia sp., Consolida regalis, Clematis recta, Eranthis hiemalis L., Helleborus foetidus L., H. niger L., H. viridis, Isopyrum thalictroides, and Aristolochia clematitis. From Consolida regalis a quaternary alkaloid (iodide C22H34NO2I) was isolated as the main component, probably of diterpenoid type. A small amount of coptisine was isolated from Isopyrum thalictroides and Aquilegia sp.

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12

Jesse, Patrick, Gritt Mottke, Jürgen Eberle, Georg Seifert, Günter Henze, and Aram Prokop. "Apoptosis-inducing activity of Helleborus niger in ALL and AML." Pediatric Blood & Cancer 52, no. 4 (December 17, 2008): 464–69. http://dx.doi.org/10.1002/pbc.21905.

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13

Salopek-Sondi, B. "Developing fruit direct post-floral morphogenesis in Helleborus niger L." Journal of Experimental Botany 53, no. 376 (September 1, 2002): 1949–57. http://dx.doi.org/10.1093/jxb/erf047.

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Vitalini, Sara, Alessandra Braca, and Gelsomina Fico. "Study on secondary metabolite content of Helleborus niger L. leaves." Fitoterapia 82, no. 2 (March 2011): 152–54. http://dx.doi.org/10.1016/j.fitote.2010.08.012.

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Turek, Claudia, Anja Herrick, Julia Bertrams, Nora Mörbt, Christiane Beckmann, Margit Barbara Müller, Peter Vögele, and Florian Conrad Stintzing. "Preclinical safety assessment of an aqueous fermented Helleborus niger plant extract." Toxicology Letters 258 (September 2016): S322. http://dx.doi.org/10.1016/j.toxlet.2016.06.2096.

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Büssing, A., and K. Schweizer. "Effects of a phytopreparation from Helleborus niger on immunocompetent cells in vitro." Journal of Ethnopharmacology 59, no. 3 (January 1998): 139–46. http://dx.doi.org/10.1016/s0378-8741(97)00114-1.

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Schink, Michael, Manuel Garcia-Käufer, Julia Bertrams, Sarina M. Duckstein, Margit B. Müller, Roman Huber, Florian C. Stintzing, and Carsten Gründemann. "Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells." Journal of Ethnopharmacology 159 (January 2015): 129–36. http://dx.doi.org/10.1016/j.jep.2014.11.003.

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Tarkowski, P. "Cytokinins in the perianth, carpels, and developing fruit of Helleborus niger L." Journal of Experimental Botany 57, no. 10 (May 19, 2006): 2237–47. http://dx.doi.org/10.1093/jxb/erj190.

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Jesse, P., G. Mottke, J. Eberle, G. Henze, and A. Prokop. "Helleborus niger as new cytostatic compound against lymphoma and leukemia in childhood." European Journal of Integrative Medicine 1 (November 2008): 5–6. http://dx.doi.org/10.1016/j.eujim.2008.08.090.

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Migeod, Friedrich, and Vera Kneer. "Anwendung von Helleborus niger bei individueller integrativer Therapie eines metastasierten Mammakarzinoms mit Pleuraerguss." Deutsche Zeitschrift für Onkologie 48, no. 03 (October 5, 2016): 120–25. http://dx.doi.org/10.1055/s-0042-113495.

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О.Г., БУТУЗОВА. "ОСОБЕННОСТИ ФОРМИРОВАНИЯ СЕМЯН У PULSATILLA VULGARIS И HELLEBORUS NIGER (RANUNCULACEAE) С ДОРАЗВИТИЕМ ЗАРОДЫША." Ботанический журнал 103, no. 3 (2018): 313–30. http://dx.doi.org/10.1134/s0006813618030031.

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Ayele, Belay T., Volker Magnus, Snježana Mihaljević, Tatjana Prebeg, Rozelinda Čož-Rakovac, Jocelyn A. Ozga, Dennis M. Reinecke, et al. "Endogenous Gibberellin Profile During Christmas Rose (Helleborus niger L.) Flower and Fruit Development." Journal of Plant Growth Regulation 29, no. 2 (December 3, 2009): 194–209. http://dx.doi.org/10.1007/s00344-009-9124-5.

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23

Yokosuka, Akihito, Mina Inomata, Yuka Yoshizawa, Tomoki Iguchi, and Yoshihiro Mimaki. "Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity." Journal of Natural Medicines 75, no. 2 (January 27, 2021): 393–402. http://dx.doi.org/10.1007/s11418-021-01481-6.

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Christiaens, A., E. Dhooghe, D. Pinxteren, and M. C. Van Labeke. "Flower development and effects of a cold treatment and a supplemental gibberellic acid application on flowering of Helleborus niger and Helleborus x ericsmithii." Scientia Horticulturae 136 (March 2012): 145–51. http://dx.doi.org/10.1016/j.scienta.2012.01.017.

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Salopek-Sondi, Branka. "Reproductive Development of the Christmas Rose (Helleborus niger L.): The Role of Plant Hormones." Croatica Chemica Acta 84, no. 2 (2011): 277–85. http://dx.doi.org/10.5562/cca1820.

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Salopek-Sondi, Branka, Maja Kovač, Nikola Ljubešić, and Volker Magnus. "Fruit initiation in Helleborus niger L. triggers chloroplast formation and photosynthesis in the perianth." Journal of Plant Physiology 157, no. 4 (October 2000): 357–64. http://dx.doi.org/10.1016/s0176-1617(00)80020-6.

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Müller, Margit B., Julia Bertrams, and Florian C. Stintzing. "Stability of protoanemonin in plant extracts from Helleborus niger L. and Pulsatilla vulgaris Mill." Journal of Pharmaceutical and Biomedical Analysis 188 (September 2020): 113370. http://dx.doi.org/10.1016/j.jpba.2020.113370.

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Niimi, Yoshiji, Dong-Sheng Han, and Satoshi Abe. "Temperatures affecting embryo development and seed germination of Christmas rose (Helleborus niger) after sowing." Scientia Horticulturae 107, no. 3 (February 2006): 292–96. http://dx.doi.org/10.1016/j.scienta.2005.08.007.

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Meiners, J., and T. Winkelmann. "EMBRYO RESCUE TO OVERCOME BARRIERS IN THE INTERSPECIFIC CROSS OF HELLEBORUS × HYBRIDUS AND H. NIGER." Acta Horticulturae, no. 961 (October 2012): 253–59. http://dx.doi.org/10.17660/actahortic.2012.961.32.

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Poupet, R., L. Cardin, A. Henri, and J. P. Onesto. "HEALTHY IN VITRO PROPAGATION BY MERISTEM TIP CULTURE OF HELLEBORUS NIGER¿S SELECTED CLONE FOR CUT FLOWER." Acta Horticulturae, no. 725 (November 2006): 301–10. http://dx.doi.org/10.17660/actahortic.2006.725.37.

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Duckstein, Sarina M., and Florian C. Stintzing. "LC–MSn characterization of steroidal saponins in Helleborus niger L. roots and their conversion products during fermentation." Steroids 93 (January 2015): 47–59. http://dx.doi.org/10.1016/j.steroids.2014.09.011.

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Gabryszewska, Eleonora Anna. "Effect of different sucrose and nitrogen salt levels in the medium and temperature on in vitro propagation of Helleborus niger L." Acta Agrobotanica 32, no. 2 (2015): 161–71. http://dx.doi.org/10.5586/aa.2015.016.

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Helleborus niger L. is a rhizomatous, herbaceous perennial with overwintering, divided, basal leaves. The objective of the study was to investigate the influence of different levels of sucrose (10, 20, 30, 40, 50, 60, 70, and 80 g l−1) and nitrogen salts (25%, 50%, and 100% according to MS medium) as well as temperature (15°C, 20°C) on in vitro multiplication and rooting and ex vitro acclimatization of H. niger. The growth and multiplication of axillary shoots were performed on modified MS medium supplemented with various growth regulators (2iP, BAP and kinetin – each at a concentration of 1.0 mg l−1, GA3 2.5 mg l−1). For the induction of roots, the medium was supplemented with IBA 1 mg l−1 and NAA 0.1 mg l−1. Rooted plants were transplanted in a peat–perlite substrate (4:1) in a heated greenhouse for ex vitro acclimatization. The multiplication rate of H. niger shoots, in vitro rooting, and ex vitro acclimatization were strongly dependent on the sucrose/nitrogen salt relationship in the medium. The highest multiplication rate of axillary shoots (3.7) was found at a temperature of 15°C or 20°C, on the medium with cytokinins and GA3 supplemented with sucrose 20–30 g l−1 and nitrogen salts at 50%. Sucrose at a concentration of 50 g l−1 strongly stimulated the number of roots per microplant (5.8–6.0) on the media with a reduced level of nitrogen salts (25% and 50%) when the temperatures were 20°C and 15°C, respectively. The plants rooted on the media with a high sucrose/nitrogen salt ratio showed acclimatization rates which ranged from 82% to 100%. Morphological observation of plantlets revealed obvious differences in leaf shape and size and the architecture of the root system as well as differences in the developmental stages of shoots grown on media with different sucrose and nitrogen salt concentrations.

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Brcko, Ana, Aleš Pěnčík, Volker Magnus, Tatjana Prebeg, Selma Mlinarić, Jasenka Antunović, Hrvoje Lepeduš, et al. "Endogenous Auxin Profile in the Christmas Rose (Helleborus niger L.) Flower and Fruit: Free and Amide Conjugated IAA." Journal of Plant Growth Regulation 31, no. 1 (June 28, 2011): 63–78. http://dx.doi.org/10.1007/s00344-011-9220-1.

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Kishor Kumar, V., and K. G. Lalitha. "Antihyperglycemic, Antihyperlipidemic and Antioxidant Activities of Ethanolic Extract of Helleborus niger Linn Roots in Streptozotocin - Nicotinamide Induced Diabetic Rats." Journal of Pharmaceutical Research 13, no. 3 (September 1, 2014): 92. http://dx.doi.org/10.18579/jpcrkc/2014/13/3/78393.

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Werthmann, Paul G., Gerhard Saltzwedel, and Gunver S. Kienle. "Minor regression and long-time survival (56 months) in a patient with malignant pleural mesothelioma under Viscum album and Helleborus niger extracts—a case report." Journal of Thoracic Disease 9, no. 12 (December 2017): E1064—E1070. http://dx.doi.org/10.21037/jtd.2017.11.56.

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Matysiak, Bożena, and Eleonora Gabryszewska. "The effect of in vitro culture conditions on the pattern of maximum photochemical efficiency of photosystem II during acclimatisation of Helleborus niger plantlets to ex vitro conditions." Plant Cell, Tissue and Organ Culture (PCTOC) 125, no. 3 (March 15, 2016): 585–93. http://dx.doi.org/10.1007/s11240-016-0972-y.

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"Helleborus niger." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19710-de.

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"Helleborus niger." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19701-de.

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"Anwendungsmöglickeiten von Helleborus niger in der Onkologie." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19705-de.

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"Präklinische Evaluation von Helleborus niger in Zellkulturversuchen." Der Merkurstab, 2009. http://dx.doi.org/10.14271/dms-19464-de.

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"Helleborus niger - Anwendungen in Innerer Medizin und Psychosomatik." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19702-de.

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"Helleborus niger: Geschichte, Botanik und differentialtherapeutische Anwendung einer Heilpflanze." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19704-de.

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Duckstein, SM, P. Lorenz, and FC Stintzing. "Hydrolysis of Helleborus niger L. saponins for aglycone analysis." Planta Medica 79, no. 13 (August 21, 2013). http://dx.doi.org/10.1055/s-0033-1352277.

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44

Hall, G. "Peronospora pulveracea. [Descriptions of Fungi and Bacteria]." IMI Descriptions of Fungi and Bacteria, no. 120 (August 1, 1994). http://dx.doi.org/10.1079/dfb/20056401198.

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Abstract A description is provided for Peronospora pulveracea. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Helleborus caucasicus, H. corsicus (= H. argutifolius), H. foetidus, H. niger, H. purpurascens, H. viridis. DISEASE: Downy mildew of Helleborus species. May develop to cover the entire plant, aborting flowering and leaving the foliage, small, crisped and uniformly grey-brown. The fungus has been reported to destroy whole stands of plants. GEOGRAPHICAL DISTRIBUTION: Asia-Temperate: Azerbaijan, Republic of Georgia. Europe: Austria, Denmark, Eire, France, Germany, Italy, The Netherlands, Poland, Portugal, Romania, Switzerland, UK (England), Yugoslavia. TRANSMISSION: By conidia which are dispersed by wind or rain-splash, and by perennation as mycelium in the rhizome.

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"Klinische Erfahrungen mit Helleborus niger bei Tumor- und AIDS-Kranken." Der Merkurstab, 1995. http://dx.doi.org/10.14271/dms-16797-de.

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"Helleborus niger - Inhaltsstoffe, In-vitro-Aktivität und Herstellung von WALA Arzneimitteln." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19708-de.

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"Neuentdeckung einer bedeutenden Heilpflanze: Die Christrose (Helleborus niger L.) - Teil 1." Der Merkurstab, 2006. http://dx.doi.org/10.14271/dms-18991-de.

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"Neuentdeckung einer bedeutenden Heilpflanze: Die Christrose (Helleborus niger L.) - Teil II." Der Merkurstab, 2010. http://dx.doi.org/10.14271/dms-19700-de.

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Delebinski, C., G. Kauczor, P. Jesse, K. Seeger, G. Henze, and G. Seifert. "P01.16. A root extract of Helleborus niger possess cytotoxic properties in neuroblastoma cells." BMC Complementary and Alternative Medicine 12, S1 (June 2012). http://dx.doi.org/10.1186/1472-6882-12-s1-p16.

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Záveská, Eliška, Philipp Kirschner, Božo Frajman, Johannes Wessely, Wolfgang Willner, Andreas Gattringer, Karl Hülber, Desanka Lazić, Christoph Dobeš, and Peter Schönswetter. "Evidence for Glacial Refugia of the Forest Understorey Species Helleborus niger (Ranunculaceae) in the Southern as Well as in the Northern Limestone Alps." Frontiers in Plant Science 12 (May 10, 2021). http://dx.doi.org/10.3389/fpls.2021.683043.

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Abstract:

Glacial refugia of alpine and subnival biota have been intensively studied in the European Alps but the fate of forests and their understory species in that area remains largely unclear. In order to fill this gap, we aimed at disentangling the spatiotemporal diversification of disjunctly distributed black hellebore Helleborus niger (Ranunculaceae). We applied a set of phylogeographic analyses based on restriction-site associated DNA sequencing (RADseq) data and plastid DNA sequences to a range-wide sampling of populations. These analyses were supplemented with species distribution models generated for the present and the Last Glacial Maximum (LGM). We used exploratory analyses to delimit genomically coherent groups and then employed demographic modeling to reconstruct the history of these groups. We uncovered a deep split between two major genetic groups with western and eastern distribution within the Southern Limestone Alps, likely reflecting divergent evolution since the mid-Pleistocene in two glacial refugia situated along the unglaciated southern margin of the Alps. Long-term presence in the Southern Limestone Alps is also supported by high numbers of private alleles, elevated levels of nucleotide diversity and the species’ modeled distribution at the LGM. The deep genetic divergence, however, is not reflected in leaf shape variation, suggesting that the morphological discrimination of genetically divergent entities within H. niger is questionable. At a shallower level, populations from the Northern Limestone Alps are differentiated from those in the Southern Limestone Alps in both RADseq and plastid DNA data sets, reflecting the North-South disjunction within the Eastern Alps. The underlying split was dated to ca. 0.1 mya, which is well before the LGM. In the same line, explicit tests of demographic models consistently rejected the hypothesis that the partial distribution area in the Northern Limestone Alps is the result of postglacial colonization. Taken together, our results strongly support that forest understory species such as H. niger have survived the LGM in refugia situated along the southern, but also along the northern or northeastern periphery of the Alps. Being a slow migrator, the species has likely survived repeated glacial-interglacial circles in distributional stasis while the composition of the tree canopy changed in the meanwhile.

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Journal articles on the topic 'Helleborus niger'

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