Relevant bibliographies by topics / HEM-3

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Academic literature on the topic 'HEM-3'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "HEM-3"

1

Tallarico, Michael, Jared Foster, Drew Seisler, Jacqueline Lafky, Arti Hurria, Aminah Jatoi, Harvey Jay Cohen, et al. "Toxicities and Related Outcomes of Elderly Patients (pts) (≥65 Years) with Hematologic Malignancies in the Contemporary Era (Alliance A151611)." Blood 128, no. 22 (December 2, 2016): 536. http://dx.doi.org/10.1182/blood.v128.22.536.536.

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Abstract Background: Contemporary approaches to non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) incorporate chemo-immunotherapy, biologic combinations, and immune modulating agents; toxicities in elderly pts (³65 years) receiving these therapies are not well studied. Further, clinical and biologic factors predicting these toxicities in pts receiving biologic therapy remain undefined. Methods: We reviewed data on NHL and/or CLL pts treated prospectively on 14 studies by the Alliance for Clinical Trials in Oncology from 2004-2014 (Table 1). Toxicity was assessed per the NCI CTCAE at the time of trial enrollment, and the probabilities of experiencing grade 3 and grade 4 hematologic (hem) and non-hematologic (non-hem) toxicities were modeled as a function of age (³65 years vs. < 65), time on study, treatment (biologics only vs. biologic + chemotherapy), gender, race, LDH, performance status (PS), stage, and an age-by-treatment interaction using logistic regression. Results: A total of 1199 pts (409 age ³ 65; 790 age < 65; 736=CLL and 463=NHL) were included. Among these patients, 493 received only biologic therapy (166 age ³ 65; 327 age < 65; 104 CLL; 389 NHL), and 706 received biologic + chemotherapy (243 age ³ 65; 463 age < 65; 632 CLL; 74 NHL). Among CLL pts (259 pts ³ 65), the effect of age on the probability of experiencing a grade 3 heme toxicity differed by treatment type (age-by-treatment interaction p = 0.047). Specifically, the adjusted odds ratio (OR) (age ³ 65 vs. < 65) for pts receiving only biologic therapy was 3.075 (95% CI: 1,15-8.25), and that for pts receiving biologic + chemotherapy was 1.044 (95% CI: 0.69 - 1.57). Similar results were seen in CLL pts for grade 4 heme toxicities (age-by-treatment interaction p = 0.033; biologic OR 6.937, 95% CI: 1.76-27.35; biologic + chemo OR 1.484, 95% CI: 1.04-2.13). No such interactions were found in CLL pts for grade 3 and 4 non-hem toxicities; however, older pts had significantly higher odds of experiencing a grade 3 non-hem toxicity than younger pts (adjusted OR 1.40; p = 0.047; 95% CI: 1.004-1.96). No age group differences were found in CLL pts for grade 4 non-hem toxicity. Similar analyses were performed for NHL pts (150 pts ³ 65), but no significant age group differences were found. Among CLL pts, women had significantly higher odds of experiencing a grade 3 heme toxicity than men (OR 2.01; p = 0.0007); no difference in grade 3 non-hem or any grade 4 toxicity was noted. Non-Caucasian CLL pts had higher odds of experiencing a grade 4 non-hem toxicity than Caucasians (OR 2.892; p = 0.0029), but no other toxicity differences were found. Worse PS was associated with increased toxicities (OR 1.871; p = 0.0009: grade 3 heme; OR 1.647; p = 0.0025: grade 3 non-hem; OR 1.410; p = 0.0448: grade 4 heme, and OR 1.931; p = 0.0252: grade 4 non-hem). CLL pts with advanced stage disease had higher odds of experiencing a heme toxicity (grade 3: OR 1.95; p = 0.0007, grade 4: OR 1.451; p = 0.0329), but no stage associations were found for non-hem toxicities. Among NHL pts, men had significantly higher odds of experiencing a grade 4 hematologic toxicity than women (OR 4.351; p = 0.0169), but no other toxicity differences were found. An increase in LDH was associated with significantly higher odds of experiencing grade 3 non-hem and grade 4 heme toxicities (grade 3 non-heme: OR 1.633; p = 0.021, grade 4 heme: OR 2.039, p = 0.0182), but no such effect was found for grade 3 heme or grade 4 non-hem. Worse PS was associated with higher odds of experiencing grade 3 toxicities (heme: OR 2.025; p = 0.0344, non-hem: OR 2.458; p = 0.0013), but no such differences were found for grade 4 toxicities. No significant stage or race effects were found in NHL patients. Conclusion: In pts ³65 years who have CLL or NHL, we identified several clinical and disease-related factors as potential predictors of developing grade 3 and/or 4 heme and non-hem toxicities (Table 2). A prognostic model is being constructed to predict toxicities in these under-studied pts to guide management and monitoring. Further, the impact of these toxicities on outcomes is being analyzed and will be presented at the meeting. Disclosures Hurria: Celgene: Other: Research; Optum Health Care SOlutions: Consultancy, Other: Conference panel, research; Boehringer Ingelheim Pharmaceuticals: Consultancy; Sanofi: Consultancy; Carevive: Consultancy; Novartis: Other: Research; GTx, Inc: Consultancy. Bartlett:Gilead: Consultancy. Cheson:Gilead: Research Funding; Acerta: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pharmacyclics: Membership on an entity's Board of Directors or advisory committees, Research Funding. Nabhan:Infinity: Consultancy; Abbvie: Consultancy; Cardinal Health: Consultancy; Seattle Genetics: Research Funding; Genentech: Consultancy, Research Funding; Astellas: Research Funding; Celgene Corporation: Consultancy, Research Funding.
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Jordan, P. M., B. I. A. Mgbeje, S. D. Thomas, and A. F. Alwan. "Nucleotide sequence for the hemD gene of Escherichia coli encoding uroporphyrinogen III synthase and initial evidence for a hem operon." Biochemical Journal 249, no. 2 (January 15, 1988): 613–16. http://dx.doi.org/10.1042/bj2490613.

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1. The hemD gene, encoding uroporphyrinogen III synthase, has been located adjacent to the hemC gene at 85 min on the Escherichia coli chromosome. 2. The entire nucleotide sequence (741 base pairs) of the hemD gene is reported. 3. E. coli strains harbouring plasmics containing the hemD gene produce greatly elevated levels of uroporphyrinogen III synthase. 4. Purified uroporphyrinogen III synthase, isolated from the hemD-containing strain ST1046, has an Mr of 29,000, in close agreement with that predicted from the nucleotide sequence. 5. The existence of a hem operon is suggested.
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3

Ullah, Riaz, Mansour S. Alsaid, Abdelaaty A. Shahat, Almoqbil Abdulaziz Naser, Abdullah A. Al-Mishari, Muhammad Adnan, and Akash Tariq. "Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats." Open Chemistry 16, no. 1 (March 2, 2018): 133–40. http://dx.doi.org/10.1515/chem-2018-0021.

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AbstractThe detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of safe hepatoprotective agents remains an unmet need. Therefore, we investigated the antioxidant effects of methanolic and n-hexane fractions of Zilla spinosa (ZSM and ZSH, respectively) and Hammada elegans (HEM and HEH, respectively) against carbon tetrachloride (CCl4)-induced liver toxicity in rats. Antioxidant activity was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The rats were divided into 11 groups (n=6)–group, 1 (control), group 2 (CCl4 only), group 3 (CCl4+silymarin 10 mg/kg), group 4 (CCl4+HEM 250 mg/kg), group 5 (CC14+HEM 500 mg/kg), group 6 (CCl4+HEH 250 mg/kg), group, 7 (CCl4+HEH 500 mg/kg), group, 8 (CCl4+ZSM 250 mg/kg), group 9 (CCl4+ZSM 500 mg/kg), group 10 (CCl4+ZSH 250 mg/kg), and group 11 (CCl4+ZSH 500 mg/kg). Serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase, and total bilirubin were measured. The extent of hepatic injury was histopathologically assessed. Treatment with ZSM and ZSH at 250 and 500 mg/kg did not significantly affect biochemical results compared with the CCl4 only group. However, treatment with both HEM and HEH at 250 and 500 mg/kg provided significant (p<0.001) results compared with the CCl4 only group. These results were consistent with histological findings. HEM and HEH at 250 μg/mL significantly inhibited DPPH radical formation by 38.E6 and 35.65%, rerpectively. However antioxidant effects of ZSM and ZSH were insignificant.
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Liu, Wen-Chao, Hyeok-Min Yun, Seung-Ho Pi, and In-Ho Kim. "Supplementing lactation diets with herbal extract mixture during summer improves the performance of sows and nursing piglets." Annals of Animal Science 17, no. 3 (July 26, 2017): 835–47. http://dx.doi.org/10.1515/aoas-2016-0084.

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Abstract A total of 45 Landrace × Yorkshire multiparous sows were used to evaluate the effect of dietary herbal extract mixture (Scutellaria baicalensis and Lonicera japonica, HEM) supplementation in lactating sows under heat stress. Sows were randomly allotted to 1 of 3 dietary treatments: 1) CON, basal diet; 2) TRT 1, basal diet with 5 g/d HEM; 3) TRT 2, basal diet with 10 g/d HEM. During lactation, dietary HEM supplementation linearly increased (P<0.05) the average daily feed intake (ADFI) and linearly decreased (P<0.05) backfat loss. The digestibility of dry matter (DM) was increased after farrowing (linear, P<0.05; quadratic, P<0.05) and weaning (linear, P<0.05) by HEM supplementation. Furthermore, HEM treatment led to a lower (linear, P<0.01) serum cortisol level. In addition, administration of HEM improved (linear, P<0.05) the piglets weaning weight and overall average daily gain (ADG) during suckling period. Meanwhile, on day 7 and 14 after birth, the fecal score of piglets was decreased (linear, P<0.01) by HEM supplementation. Taken together, under high ambient temperatures, inclusion of HEM to lactation diets could improve the feed intake, digestibility of DM, piglets weaning weight and ADG, while decreasing backfat loss, serum cortisol level, as well as the diarrhea of piglets.
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Bowen, Jennifer. "Notes on the Vanuatu Megapode Megapodius layardi on Ambrym, Vanuatu." Bird Conservation International 6, no. 4 (December 1996): 401–8. http://dx.doi.org/10.1017/s0959270900001842.

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SummaryThe Vanuatu Megapode Megapodius layardi is endemic to Vanuatu (formerly New Hebrides). On the volcanic island of Ambrym it exhibited three different incubation strategies. It incubated its eggs (1) in burrows between decaying roots of trees; (2) in burrows at large communal nesting grounds in volcanically heated soils; and (3) in burrows on sun-exposed beaches. No mounds were found. In a study by the Vanuatu Protected Areas Initiative (VPAI) nesting grounds were mapped to monitor the population. Three communal nesting grounds were surveyed. Two were on promontories and one on a beach. The burrows were classified into three categories: active, probably active and old. The density of active burrows per hectare of the three sites was 82.4 for Promontory A, 43.5 for Promontory B and 10.5 for Buwoma Beach. Additional information of this poorly known species was collected from villagers in the north-west and west of the island. They have noticed a decrease in the numbers of birds and have expressed concern about the future of the species.Le Mègapode de Vanuatu, Mègapodius layardi, est uniquement originaire de Vanuatu, (dit 'Nouvelles Hebrides' autrefois). Sur l'île volcanique d'Ambrym, il fait preuve de trois stratégies d'incubation différentes. II couve ses oeufs premièrement dans des terriers situés entre les racines pourries des arbres, duexièmement dans des terriers situés dans des grands terrains communaux de nids, et troisièmement dans des terriers situés sur des plages exposées au soleil. Aucan monticule n'est évident. Lors d'une étude par l'lnitiative des Terrains Protégés de Vanuatu (Vanuatu Protected Areas Initiative, VPAI), les terrains de nids furent plannifiés afin d'étudier la population. Trois terrains communaux de nids furent enquêtés. Les terriers furent classifiés en trois catégories; actifs, probablement actifs, et anciens. La densité des terriers actifs par hectare des trois terrains étaient de 82.4 pour le Cap A, 43.5 pour le Cap B, et de 10.5 pour la plage de Buwoma. Des données additionelles pur cet espèce peu connu furent rassemblées des villageois dand le nord ouest et l'ouest de Iîle. Ils ont constaté une diminuation des nombres d'oiseaux et ils ont exprimé leurs soucis vis-à-vis le future de l'espèce.Wan pijin, nem blong hem Namalau, Megapodius layardi, i stap long Vanuatu nomo (bifo, New Hebrides i nem blong Vanuatu). Long Ambrym, wan aelan wetem volkeno, Namalau i yusum trifala defren fasin long makem nes blong hem so heg blong hem i stap gud nomo; 1) ol i putum heg blong hem nekis rus bio tri wea ol rus i rotin 2) ol i putum heg blong hem wetem plenti narafala Namalau heg long graon wea volkeno i mekem groan i hot, 3) ol i putum heg blong hem insead sanbij wea san i makem i hot. Long Ambrym ol man i no fanem ples wea Namalau putum heg blong hem insaed wanples wea i gat plenti lif mo tri antap graon. Vanuatu Protected Areas Initiative (VPAI) i mekem wan stadi long ples wea ol Namalau i putum heg mo ol i mekem wan map. VPAI i lukum long trifala ples wea Namalau i putum heg. Tufala ples i stap long graon wea i go aot long solwota mo namba tri ples i stap long wan sanbij. I gat trifala defren grup blong ples wea ol i putum heg; niufala, klosap niufala mo olfala. Namba blong nuifala ples wea Namalau i putum heg insaed long wan hectare i 82.4 long pies A, 43.5 long ples B mo 10.5 long Buwoma sanbij. I no gat plenti save blong Namalau mo VPAI toktok plenti wetem ol man blong vilej long notwes mo wes Ambrym. Ol man is e namba blong Namalau i go daon bigwan mo ol i wari long fiuja long Namalau.
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Morris, Mackenzie C., Grace M. Niziolek, Thomas C. Blakeman, Sabre Stevens-Topie, Rosalie Veile, Victor Heh, Basilia Zingarelli, Dario Rodriquez, Richard D. Branson, and Michael D. Goodman. "Intrathoracic Pressure Regulator Performance in the Setting of Hemorrhage and Acute Lung Injury." Military Medicine 185, no. 7-8 (April 30, 2020): e1083-e1090. http://dx.doi.org/10.1093/milmed/usz485.

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Abstract Introduction: Intrathoracic pressure regulation (ITPR) can be utilized to enhance venous return and cardiac preload by inducing negative end expiratory pressure in mechanically ventilated patients. Previous preclinical studies have shown increased mean arterial pressure (MAP) and decreased intracranial pressure (ICP) with use of an ITPR device. The aim of this study was to evaluate the hemodynamic and respiratory effects of ITPR in a porcine polytrauma model of hemorrhagic shock and acute lung injury (ALI). Methods: Swine were anesthetized and underwent a combination of sham, hemorrhage, and/or lung injury. The experimental groups included: no injury with and without ITPR (ITPR, Sham), hemorrhage with and without ITPR (ITPR/Hem, Hem), and hemorrhage and ALI with and without ITPR (ITPR/Hem/ALI, Hem/ALI). The ITPR device was initiated at a setting of −3 cmH2O and incrementally decreased by 3 cmH2O after 30 minutes on each setting, with 15 minutes allowed for recovery between settings, to a nadir of −12 cmH2O. Histopathological analysis of the lungs was scored by blinded, independent reviewers. Of note, all animals were chemically paralyzed for the experiments to suppress gasping at ITPR pressures below −6 cmH2O. Results: Adequate shock was induced in the hemorrhage model, with the MAP being decreased in the Hem and ITPR/Hem group compared with Sham and ITPR/Sham, respectively, at all time points (Hem 54.2 ± 6.5 mmHg vs. 88.0 ± 13.9 mmHg, p &lt; 0.01, −12 cmH2O; ITPR/Hem 59.5 ± 14.4 mmHg vs. 86.7 ± 12.1 mmHg, p &lt; 0.01, −12 cmH2O). In addition, the PaO2/FIO2 ratio was appropriately decreased in Hem/ALI compared with Sham and Hem groups (231.6 ± 152.5 vs. 502.0 ± 24.6 (Sham) p &lt; 0.05 vs. 463.6 ± 10.2, (Hem) p &lt; 0.01, −12 cmH2O). Heart rate was consistently higher in the ITPR/Hem/ALI group compared with the Hem/ALI group (255 ± 26 bpm vs. 150.6 ± 62.3 bpm, −12 cmH2O) and higher in the ITPR/Hem group compared with Hem. Respiratory rate (adjusted to maintain pH) was also higher in the ITPR/Hem/ALI group compared with Hem/ALI at −9 and − 12 cmH2O (32.8 ± 3.0 breaths per minute (bpm) vs. 26.8 ± 3.6 bpm, −12 cmH2O) and higher in the ITPR/Hem group compared with Hem at −6, −9, and − 12 cmH2O. Lung compliance and end expiratory lung volume (EELV) were both consistently decreased in all three ITPR groups compared with their controls. Histopathologic severity of lung injury was worse in the ITPR and ALI groups compared with their respective injured controls or Sham. Conclusion: In this swine polytrauma model, we demonstrated successful establishment of hemorrhage and combined hemorrhage/ALI models. While ITPR did not demonstrate a benefit for MAP or ICP, our data demonstrate that the ITPR device induced tachycardia with associated increase in cardiac output, as well as tachypnea with decreased lung compliance, EELV, PaO2/FIO2 ratio, and worse histopathologic lung injury. Therefore, implementation of the ITPR device in the setting of polytrauma may compromise pulmonary function without significant hemodynamic improvement.
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Ahn, Jemin, Lei Cheng, and In Ho Kim. "121 Dietary astragalus membranaceus and codonopsis pilosula extracts supplementation increases growth performance and FMD antibody titers in growing-finishing pigs." Journal of Animal Science 97, Supplement_2 (July 2019): 68–69. http://dx.doi.org/10.1093/jas/skz122.126.

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Abstract An experiment was conducted to evaluate the effects of herbal extract mixture (HEM, Astragalus membranaceus and Codonopsis pilosula) supplementation on growth performance, nutrient digestibility, and FMD antibody titers in growing-finishing pigs. A total of 120 FMD type O vaccinated growing pigs [(Yorkshire × Landrace) × Duroc] with an average initial BW of 25.19 ± 1.80 kg were randomly allotted into 3 treatments with 8 replicate of 5 pigs per pen for a 16-week feeding study. All pigs were vaccinated against FMD. Treatments consisted of CON, Corn-soybean meal based diet; TRT1, CON + 0.05% HEM; TRT2, CON + 0.1% HEM. Vaccinated pigs fed 0.1% HEM showed higher (P < 0.05) BW and ADG at week 12, 16, and overall period. The supplementation of HEM had no effect on DM, N or GE throughout the experiment (P > 0.05). Feeding 0.1% HEM showed higher FMD type O antibody titers (P < 0.05) at week 14 compared with non-supplemented group. These results indicated that 0.1% HEM supplementation conferred anti-viral effect against FMD, thereby improving ADG in the growing-finishing pigs. Herbal extract mixture could potentially be used as an anti-viral agent against FMDV.
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Hao, Lijun, Yuxi Xie, Guikai Wu, Aibin Cheng, Xiaogang Liu, Rongjuan Zheng, Hong Huo, and Junwei Zhang. "Protective Effect ofHericium erinaceuson Alcohol Induced Hepatotoxicity in Mice." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/418023.

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We investigated the effects ofHericium erinaceus(HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), and activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively. HEM administration markedly(P<0.05)decreased serum ALT, AST, and MDA levels. The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage. In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.
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Michot, Jean-Marie, Nicolas Delanoy, Thibault Comont, Nora Kramkimel, Romain Dupont, Julien Lazarovici, Stéphane Champiat, et al. "Immunological Cytopenias Induced By Anti-Programmed Cell Death (ligand) 1 Antibodies." Blood 132, Supplement 1 (November 29, 2018): 2412. http://dx.doi.org/10.1182/blood-2018-99-110875.

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Abstract Background. Anti-programmed death (ligand) 1 (PD-(L)1) antibodies are novel immunotherapies for cancer. Anti-PD(L)1 can induce immune-related adverse events (irAEs), which most frequently affect the skin, endocrine glands, lung, liver and digestive tract, however all organs including the hematopoietic system can potentially be involved. Hematologic irAEs (hem-irAEs) have not yet been extensively characterized. This study based on a pharmacovigilance academic registry aims to provide a comprehensive report of hem-irAEs. Patients and methods. All grade 2 or higher hem-irAEs recorded in pharmacovigilance databases were recorded in this study over the period 2013-2018. Pharmacovilance database included REISAMIC (Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie) and ImmunoTOX committee of Gustave Roussy, and the French nationwide CeReCAI registry (Centre de Référence des Cytopénies Auto-Immunes de l'adulte). Prevalence of hem-irAE was calculated in the prospective REISAMIC registry. The hem-irAE's severity was assessed according to the Common Terminology Criteria for Adverse Events (version 4.03). Results. Thirty-five patients (21 men and 14 women) with hem-irAEs related to anti-PD(L)1s were recorded. The prevalence of grade ≥2 hem-irAEs among patients treated with anti-PD(L)1s was estimated to 0.54%. The patients' median age was 65 years (range: 30-90), tumor types were melanoma (n=15), non-small-cell lung carcinoma (n=12), lymphoma (n=4), and other types (n=4). A concomitant medical history of chronic lymphocytic leukemia was found in 3 (9%) patients. The hem-irAEs were classified as neutropenia (n=9; 26%), auto-immune hemolytic anemia (n=9; 26%), immune thrombocytopenia (IT) (n=9; 26%), pancytopenia or aplastic anemia (n=5; 14%), bicytopenia (n=2; 6%) and pure-red cell aplasia (n=1; 3%). The maximum grade of severity reported was grade 2 in 3 (9%) patients, grade 3 in 8 (23%) patients and grade 4 in 24 (69%) patients. Two patients (6%) had a poor outcome and died in the course of the hem-irAE. Treatments given for the hem-irAE were steroids in 31 (89%) patients, granulocyte colony-stimulating factor in 13 (37%) patients, intravenous immunoglobulins in 6 (17%) patients and rituximab in 2 (6%) patients. The median time to onset from anti-PD(L)1 initiation was 10.1 weeks (range 0.9 - 198.0). With a median follow-up of 19 (range 2-180) weeks, the rate of resolution of hem-irAE was 67% (78% for IT and 40% for aplastic anemia patients, p=0.524). After resolution, 6/35 (17%) patients were rechallenged and 3 of them (50%) recurred the same hem-irAE. Conclusion. The clinical spectrum of hematologic irAE is wide and dominated by neutropenia, hemolytic anemia and immune thrombocytopenia. Aplastic anemia is rarer and present as a life-threatening condition. The prevalence of grade ≥2 hematologic irAEs following anti-PD(L)1 was 0.54%. The recurrence rate after rechallenge was 50%. Further prospective investigations are warranted to better detect and manage hematologic immune-related adverse events. Disclosures Herbaux: Gilead Sciences, Inc.: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Janssen: Consultancy, Honoraria. Maerevoet:abbvie: Membership on an entity's Board of Directors or advisory committees, Other: travel grant; roche: Other: travel grant; takeda: Membership on an entity's Board of Directors or advisory committees, Other: travel grant; Karyopharm: Membership on an entity's Board of Directors or advisory committees. Ribrag:Servier: Consultancy, Honoraria; Amgen: Research Funding; BMS: Consultancy, Honoraria, Other: travel; Incyte Corporation: Consultancy; Infinity: Consultancy, Honoraria; NanoString Technologies: Consultancy, Honoraria; MSD: Honoraria; Gilead: Consultancy, Honoraria; Roche: Honoraria, Other: travel; argenX: Research Funding; epizyme: Consultancy, Honoraria; pharmamar: Other: travel.
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Tecle, I. Y., J. L. Hansen, A. N. Pell, and D. R. Viands. "Divergent phenotypic selection for alfalfa cell wall fractions and indirect response in digestibility." Canadian Journal of Plant Science 88, no. 5 (September 1, 2008): 891–98. http://dx.doi.org/10.4141/cjps07134.

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An alfalfa (Medicago sativa L.) breeding strategy to decrease slowly digestible or indigestible fiber and simultaneously increase digestible fiber could improve forage quality without reducing total fiber. The objectives were: (1) to estimate selection responses from divergent and opposite direction selections of (i) hemicellulose (HEM) and acid detergent fiber (ADF), (ii) acid detergent lignin (LIG) and HEM + cellulose (CEL) and (iii) CEL and HEM + LIG, and (2) to determine correlated responses in in vitro true digestibility (IVTD). Selection progress was evaluated in replicated plot trials at two locations, sampled for 2 or 3 yr. Selection for divergent HEM and ADF resulted in change only for ADF [10.9 g kg-1 dry matter (DM)]. Selection for divergent LIG and HEM + CEL, resulted in same direction change in LIG (3.3 g kg-1 DM). Selection for divergent CEL and HEM + LIG resulted in change only in CEL (5.1 g kg-1 DM). Low LIG and high HEM + CEL, and low ADF and high HEM populations had 9.7 and 8.3 g kg-1 DM higher IVTD than their counterparts, respectively. The first cycle of selection for the fiber components simultaneously in the opposite directions was not successful. However, reduced LIG or ADF concentration appears to increase alfalfa forage digestibility and decrease total fiber concentration. Key words: Alfalfa, cell wall, hemicellulose, cellulose, lignin, digestibility
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Dissertations / Theses on the topic "HEM-3"

1

Gordon, Keith. "MACT Implementation at an Organic Chemical Manufacturing Facility: Human Health Risk Reduction." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1222.

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Human health risk assessments are used by environmental regulatory agencies to determine risk from Hazardous Air Pollutants (HAPs). In this study, the Human Exposure Model (HEM-3) was used to compare the cancer and non-cancer inhalation health effects of a single organic chemical manufacturing facility in Geismar, Louisiana prior to and after Maximum Achievable Control Technologies (MACT) were implemented. The results indicate significant reductions in both cancer risk and non-cancer hazards. The analysis also indicated that the equivalent cancer risk reduction could have been achieved by addressing MACT in only one production process and one single pollutant (ethylene dichloride) within that process. This demonstrates the value that these risk assessments have at evaluating emissions at the facility level, and how they could be used in the control strategy decision making process.
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Roa, Nadia C. "Human Health Risk Assessment for Petroleum Refining Industry of the Remaining Air Toxics after MACT I Emissions Reductions." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/849.

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Inhalation risks on human health for hazardous air pollutants emitted from MACT I petroleum refining industry were determined using EPA HEM-3 Program. Methodology included compiling vertical and fugitive emissions from 2002 National Emissions Inventory for sources inside two facilities in Louisiana, 'Motiva Norco' and 'Valero St. Charles' refineries. Six cases were modeled applying EPA criteria, where cancer risks are 'low' if the probability is. 1/1, 000, 000, and non-cancer risks are harmful when hazard quotient is > 1. It was demonstrated that fugitive emissions have more impact on human health than the verticals because of their significant portion of the total refining emissions. HAPs can cause moderate adverse effects in humans living nearby refineries, as 113 people resulted in high risk of respiratory problems with Valero emissions, 4571 people resulted in 'moderate' risk of getting cancer with Motiva emissions, 2702 people with Valero emissions, and 11, 282 people with both refineries' emissions.
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Nagel, Olaf. "HE5-CD52 und die [alpha]1-3-Fucosyltransferasen [Alpha-1-3-Fucosyltransferasen] des humanen Nebenhodens." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968647464.

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Day, Charles Samuel Reuben. "EXOSAT observations of Her X-1 and Cen X-3." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279912.

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Chen, Caiyong. "Delineating the roles of C. elegans heme responsive genes HRG-2 AND HRG-3 in heme homeostasis." College Park, Md. : University of Maryland, 2009. http://hdl.handle.net/1903/9977.

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Thesis (Ph.D.) -- University of Maryland, College Park, 2009.
Thesis research directed by: Dept. of Animal and Avian Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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6

Hippel, Sandra Christine von. "Einfluss von Hypoxie und Adenosin-2',3'-Dialdehyd auf den S-Adenosylmethionin/S-Adenosylhomocystein Quotienten in HepG2, Sk-Hep-1, HeLa, MCF-7 und Hek-293 Zellen." [S.l. : s.n.], 2004.

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7

Hübinette, Linnea. "Hen och tjänsteperson : Före och efter F!:s motion i 3 svenska kommuner." Thesis, Södertörns högskola, Svenska, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-40923.

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I denna studie undersöks Feministiskt Initiativs (F!) motion om att byta ut könsprefixet -man till det könsneutrala -person i kommunpolitiken. Detta med fokus på bytet av tjänsteman till tjänsteperson i de utvalda kommunerna för undersökningen. Dessa är Malmö stad, där motionen gick igenom, Umeå kommun, där motionen inte gick igenom, samt Uppsala kommun där motionen gick igenom efter revidering. Jag undersöker även ordet hen och relaterar detta till motionen för att se ifall det finns tendenser till att jämnställt språk ökar. Syftet är att undersöka användningen av yrkesbeteckningarna tjänsteman och tjänsteperson samt pronomet hen i dessa tre kommuner. Detta undersöks genom en kvantitativ metod på kommunernas hemsidor där förekomster av tjänsteman, tjänsteperson och hen räknas. Mina teoretiska utgångspunkter utgår från Hirdman (1988) om genussystemet och Milles (2019) om könsprefixet -man i kommunpolitiken. Jag använder mig även av Pauwels (2011) om kvinnors förtryck i språket och Nordenstam (2003) om början på den feministiska diskursiva aktivismen. Jag har också valt att använda mig av Milles (2002) som beskriver de två typer av diskriminering som kvinnan blir utsatt för i språket samt Jobin (2004) om bland annat hur könsneutralt språk uppmärksammades i riksdagen för första gången.  Resultatet visade på att användningen av tjänsteperson har ökat i samtliga kommuner samtidigt som användningen av tjänsteman minskat. Detta även i Umeå kommun, där motionen inte gick igenom. Detta visar på hur viktig själva diskussionen om könsneutralt språk är, oavsett om motioner eller förslag om förändringar av språket, går igenom eller inte. Hen användes inte i så stor utsträckning i någon av kommunerna innan motionen tagits upp och Uppsala kommun var den kommun som använde hen i störst omfattning före motionen tagits upp. Användningen av hen har däremot ökat i alla kommunerna efter motionen tagits upp.
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Medrel, Pierre. "Amplification de puissance linéaire à haut rendement en technologie GaN intégrant un contrôle de polarisation de grille." Thesis, Limoges, 2014. http://www.theses.fr/2014LIMO0006/document.

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Cette thèse s’inscrit dans le domaine de l’amplification de puissance microonde linéaire et haut rendement en technologie GaN. Le premier chapitre décrit le contexte général de l’émission de signaux microondes de puissance pour les télécommunications sans fil, avec un focus particulier apporté sur l’amplificateur de puissance RF. Les différents critères de linéarité et d’efficacité énergétique sont introduits.Le second chapitre présente plus particulièrement la technologie GaN et le transistor de puissance comme brique de base pour l’amplification de puissance microonde. Une revue synthétique des différentes architectures relevées dans la littérature relative à l’amplification à haut rendement est faite.En troisième chapitre, le banc de mesure temporelle d’enveloppe développé et servant de support expérimental à cette étude est présenté. Les procédures d’étalonnage et de synchronisation sont décrites. En illustration, une nouvelle méthode de mesure du NPR large bande est présentée, et validée expérimentalement.Une solution d’amplification adaptative innovante est étudiée dans le quatrième chapitre, et constitue le cœur de ce mémoire. Celle-ci se base sur le contrôle dynamique de la polarisation de grille autour du point de pincement, au rythme de l’enveloppe de modulation. Un démonstrateur d’amplification 10W GaN en bande S (2.5GHz) est développé. Comparativement à la classe B fixe, une forte amélioration de la linéarité est obtenue, sans impact notable sur le rendement moyen de l’amplificateur RF. Finalement, une investigation de la technique proposée pour l’amélioration du rendement du modulateur dans l’architecture d’envelope tracking de drain est menée
This work deals with linear and high efficiency microwave power amplification in GaN technology.The first chapter is dedicated to the general context of wireless telecommunication with a special emphasis on the RF power amplifier. The most representative figures of merit in terms of linearity and power efficiency are introduced.The second chapter deals more specifically with the GaN technology and GaN-based transistor for microwave power amplification. A description of the principal architectures found in the literature related to high efficiency and linear amplification is summarized.In the third chapter, the developed envelope time-domain test bench is presented. Time-synchronization and envelope calibration procedures are discussed. As an illustration, a new specific wideband NPR measurement is presented and experimentally validated.An innovative power amplifier architecture is presented in the fourth chapter. It is based on a specific dynamic gate biasing technique of the power amplifier biased close to the pinch-off point. A 10W GaN S-band demonstrator has been developed. Compared to fixed class-B conditions, a linearity improvement has been reported without any prohibitive efficiency degradation of the RF power amplifier. Finally, an investigation of the proposed technique for the efficiency improvement in the drain envelope tracking technique is proposed
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Moura, Nelci Antunes de [UNESP]. "Efeitos da ingestão de simbiótico e indol-3-carbinol sobre o processo de carcinogênese química de cólon em ratos Wistar alimentados com dieta contendo heme." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/138850.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O ferro heme presente na carne vermelha está associado ao aumento da incidência do câncer colorretal (CCR). O heme pode catalisar a formação de compostos nitrosos e a peroxidação lipídica no lúmen intestinal. No entanto, os efeitos pró-carcinogênicos do heme podem ser inibidos por alguns compostos como os sais de cálcio, clorofila entre outros. Sabe-se que o indol-3-carbinol (I3C), presente nas plantas da família das Brassicas e os simbióticos são compostos promissores na prevenção do câncer de cólon, atuando em via de proliferação, apoptose e modulação da microbiota intestinal. Dessa forma, o objetivo desse estudo foi o de avaliar os efeitos da ingestão de simbiótico (prebiótico inulina associado ao probiótico Bifidobacterium lactis bb-12) e de I3C, isolados ou em associação sobre o processo de carcinogênese de cólon induzido pela 1,2-dimetilhidrazina (DMH) em ratos Wistar alimentados ou não com dieta suplementada com heme. Os animais foram alocados em 9 grupos, os grupos 1 a 8 (n=12) receberam quatro doses de DMH (40 mg/Kg) nas duas semanas iniciais do experimento. Os grupos 1 e 9 (n=12 e 5) receberam ração basal até o final do experimento e os grupos 2 a 8 receberam ração basal suplementada com heme, heme+I3C, heme+simbiótico, heme+I3C+simbiótico, I3C, simbiótico e I3C+simbiótico, respectivamente. A eutanásia ocorreu ao final da 25ª semana. Neste momento foi realizada a coleta do cólon com os respectivos tumores e amostras de fezes do ceco. Em seguida, procedeu-se a medida dos tumores e coleta de amostras para biologia molecular. Após a fixação em formalina tamponada e a retirada dos tumores, realizou-se a contagem de focos de criptas aberrantes (FCA) pela coloração de azul de metileno. Realizou-se a análise histológica dos tumores e a análise da expressão de 95 genes relacionados a via da carcinogênese colônica, pela técnica Taqman Low Density Array, e a expressão proteica da E-caderina, TGFB1 (Transforming growth factor beta 1) e RAF1 (Serine/threonine-protein kinase) por Western Blotting. Foram analisados os índices de proliferação celular e apoptose pelo PCNA (Proliferating cell nuclear antigen) e caspase 3-clivada, respectivamente, tanto nos cólons como em tumores, e a expressão de β-catenina e E-caderina nos tumores, por imunoistoquímica. Células da linhagem Caco-2 foram incubadas com água fecal extraída das fezes do ceco e submetidas a testes de citotoxicidade e genotoxidade pelos testes do MTT (mitochondrial tetrazolium test) e Cometa, respectivamente. Os dados foram comparados utilizando-se o software Sigma Stat 3.5 e Expression Suíte para expressão gênica. Foi observado aumento significativo no número de criptas aberrantes (CA) no grupo que recebeu heme (G2) quando comparado ao grupo que recebeu apenas ração basal (G1). Redução significativa no número de CA foi observada no grupo que recebeu heme+I3C (G3) e heme+simbiótico (G4) quando comparado ao grupo que recebeu heme (G2). O número de FCA totais com ≥ 9 criptas aberrantes foi significativamente menor no grupo que recebeu heme+simbiótico (G4) quando comparado ao grupo que recebeu heme (G2). Entretanto, aumento significativo no número de tumores com mais de 60 mm3 foi observado no grupo suplementado com heme+I3C+simbiótico (G5), quando comparado ao grupo que recebeu heme (G2). Além disso, foi observado aumento significativo na incidência de tumores invasivos no grupo que recebeu heme+I3C+simbiótico (G5) quando comparado ao grupo que recebeu heme (G2). Os tumores do grupo suplementado com heme+I3C+simbiótico (G5) apresentaram baixa expressão dos genes Cdh1, Tgfb1, Appl1 e alta expressão do Raf1, já os tumores do grupo suplementado com heme +I3C (G3) apresentaram baixa expressão do Cdh1. A água fecal do grupo que recebeu heme (G2) apresentou significativamente maior citotoxicidade e genotoxicidade quando comparado ao grupo que recebeu ração basal (G1). Com relação aos tratamentos, a água fecal do grupo que recebeu heme+I3C (G3) e heme e simbiótico (G4) apresentaram água fecal significativamente com menor potencial genotóxico quando comparada ao grupo que recebeu heme (G2). No entanto, o grupo que recebeu heme+I3C+simbiótico (G5) apresentou aumento significativo na genotoxicidade da água fecal. Dessa forma, concluímos que o heme associado a uma dieta com níveis normais de cálcio não é um potente indutor de FCA, mas aumenta a citotoxicidade e genotoxicidade da água fecal. No entanto, tanto o I3C como o simbiótico reduzem os efeitos citotóxicos/genotóxicos da ingestão de heme. Contudo, a associação do heme+I3C+simbiótico apresentou efeito promotor da carcinogênese de cólon.
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Hemin iron, which is found in red meat, catalyzes the formation of carcinogenic N-nitroso compounds and lipid peroxidation end-products in the colon lumen. The procarcinogenic effect of hemin is known to be inhibited by molecules, such as calcium, chlorophyll and others. However, the preventive effect of indole 3-carbinol and synbiotics on colon carcinogenesis remains uninvestigated. The aim of this study was to assess the modifying effects of a synbiotic (inulin+ Bifidobacterium lactis) and/or I3C against dimethylhidrazine (DMH)-induced colon carcinogenesis in hemin-fed male Wistar rats. Nine groups of animals were evaluated. Groups 1–8 received a total of four s.c. DMH injections (40 mg/kg b.w.) over 2 weeks, whereas group 9 was given EDTA solution (vehicle). Two weeks after DMH-initiation, G1 and G9 were fed a basal diet while groups G2, G3, G4, G5, G6, G7 and G8 received a basal diet containing hemin, hemin+I3C, hemin+synbiotic, hemin+I3C+synbiotic, I3C, synbiotic and I3C+synbiotic, respectively, during 23 weeks. At 25 week, all animals were killed and their colons were removed. Cecal contents were collected to determine fecal water cytotoxicity and genotoxicity (DNA damage) in Caco-2 cells. Colon tumors were measured and samples were collected and stored at -800C. The colons were fixed flat in 10% buffered formalin for 24 h and stained with 1.0% methylene blue for classical ACF analysis and quantification. Tumor incidence and multiplicity were assessed after histopathological analysis. Gene and protein expression were determined in tumor samples alone. The total number of aberrant crypts (AC) was significantly higher (p= 0.03) in the hemin group (G2) than in the group fed basal diet (G1). AC number in both hemin+I3C (G3) and hemin+synbiotic (G4) groups was also significantly lower than in the group fed hemin (G2). Tumor volume was higher in the hemin+I3C+ synbiotic (G5) group and invasive adenocarcinoma was more frequent in the hemin+I3C+synbiotic group (G5) than in the group fed hemin (G2). Colon tumor expression analysis showed that in comparison with the group fed hemin (G2), Cdh1, Tgfb1 and Appl1 were downregulated while Raf1 was upregulated in the group hemin+I3C+synbiotic (G5), and Cdh1 was down-regulated in the group hemin+I3C (G3). Fecal water cytotoxicity in the hemin group (G2) was higher than in groups fed basal diet (G1) and hemin+I3C (G3). Fecal water genotoxicity was also significantly higher in the group fed hemin alone (G2) than in the basal diet group (G1), as well as, in groups fed hemin+I3C (G3) and hemin+synbiotics (G4). However, when compared to hemin alone (G2), fecal water from group hemin+I3C+ synbiotics (G5) presented the highest DNA damage levels. Our results suggest that although hemin in a regular-calcium diet was not a powerful ACF promoter, it increased fecal water citotoxicity and genotoxicity. On the other hand, hemin associated with either I3C or synbiotics prevented ACF promotion. Nonetheless, a synergistic interaction among hemin, I3C and synbiotic did promote DMH-induced tumorigenesis.
FAPESP: 2011/23699-4
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Moura, Nelci Antunes de. "Efeitos da ingestão de simbiótico e indol-3-carbinol sobre o processo de carcinogênese química de cólon em ratos Wistar alimentados com dieta contendo heme." Botucatu, 2015. http://hdl.handle.net/11449/138850.

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Orientador: Luís Fernando Barbisan
Resumo: O ferro heme presente na carne vermelha está associado ao aumento da incidência do câncer colorretal (CCR). O heme pode catalisar a formação de compostos nitrosos e a peroxidação lipídica no lúmen intestinal. No entanto, os efeitos pró-carcinogênicos do heme podem ser inibidos por alguns compostos como os sais de cálcio, clorofila entre outros. Sabe-se que o indol-3-carbinol (I3C), presente nas plantas da família das Brassicas e os simbióticos são compostos promissores na prevenção do câncer de cólon, atuando em via de proliferação, apoptose e modulação da microbiota intestinal. Dessa forma, o objetivo desse estudo foi o de avaliar os efeitos da ingestão de simbiótico (prebiótico inulina associado ao probiótico Bifidobacterium lactis bb-12) e de I3C, isolados ou em associação sobre o processo de carcinogênese de cólon induzido pela 1,2-dimetilhidrazina (DMH) em ratos Wistar alimentados ou não com dieta suplementada com heme. Os animais foram alocados em 9 grupos, os grupos 1 a 8 (n=12) receberam quatro doses de DMH (40 mg/Kg) nas duas semanas iniciais do experimento. Os grupos 1 e 9 (n=12 e 5) receberam ração basal até o final do experimento e os grupos 2 a 8 receberam ração basal suplementada com heme, heme+I3C, heme+simbiótico, heme+I3C+simbiótico, I3C, simbiótico e I3C+simbiótico, respectivamente. A eutanásia ocorreu ao final da 25ª semana. Neste momento foi realizada a coleta do cólon com os respectivos tumores e amostras de fezes do ceco. Em seguida, procedeu-se a... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Colorectal cancer (CRC) is the third most common type of cancer worldwide. Hemin iron, which is found in red meat, catalyzes the formation of carcinogenic N-nitroso compounds and lipid peroxidation end-products in the colon lumen. The procarcinogenic effect of hemin is known to be inhibited by molecules, such as calcium, chlorophyll and others. However, the preventive effect of indole 3-carbinol and synbiotics on colon carcinogenesis remains uninvestigated. The aim of this study was to assess the modifying effects of a synbiotic (inulin+ Bifidobacterium lactis) and/or I3C against dimethylhidrazine (DMH)-induced colon carcinogenesis in hemin-fed male Wistar rats. Nine groups of animals were evaluated. Groups 1–8 received a total of four s.c. DMH injections (40 mg/kg b.w.) over 2 weeks, whereas group 9 was given EDTA solution (vehicle). Two weeks after DMH-initiation, G1 and G9 were fed a basal diet while groups G2, G3, G4, G5, G6, G7 and G8 received a basal diet containing hemin, hemin+I3C, hemin+synbiotic, hemin+I3C+synbiotic, I3C, synbiotic and I3C+synbiotic, respectively, during 23 weeks. At 25 week, all animals were killed and their colons were removed. Cecal contents were collected to determine fecal water cytotoxicity and genotoxicity (DNA damage) in Caco-2 cells. Colon tumors were measured and samples were collected and stored at -800C. The colons were fixed flat in 10% buffered formalin for 24 h and stained with 1.0% methylene blue for classical ACF analysis and qua... (Complete abstract click electronic access below)
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Books on the topic "HEM-3"

1

Emden, Jacob. Sefer Neṿeh ḥakham: Neḥelaḳ le-3 ʻinyanim, 1, Hilkhot deʻot leha-Rambam, zal, 2, Maʼamar ḥalonot aṭumot ṿe-hem shene peraḳim mi-Shemonah peraḳim leha-Rambam : 3, maʼamar ḥalon Tsuri ... ṭivʻe u-mizge ha-guf, koḥot ha-nefesh, ʻerkhe ha-midot, ha-refuʼah le-ḥole ha-midot uve-sofo beʼur maʻalat ha-dan le-khaf zekhut. [Bene Beraḳ?]: M. Bodeḳ, 1991.

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Emden, Jacob. Sefer Neṿeh ḥakham: Neḥelaḳ le-3 ʻinyanim, 1, Hilkhot deʻot leha-Rambam, zal, 2, Maʼamar ḥalonot aṭumot ṿe-hem shene peraḳim mi-Shemonah peraḳim leha-Rambam : 3, maʼamar ḥalon Tsuri ... ṭivʻe u-mizge ha-guf, koḥot ha-nefesh, ʻerkhe ha-midot, ha-refuʼah le-ḥole ha-midot uve-sofo beʼur maʻalat ha-dan le-khaf zekhut. [Bene Beraḳ?]: M. Bodeḳ, 1991.

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Het gevallen baken: Het beleg van Laken 3. Amsterdam: De Bezige Bij, 1991.

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Ken, Nagaya, ed. Burakku Jakku ni yoroshiku: Seishinka hen 3. Tōkyō: Kōdansha, 2005.

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Polet, Sybren. Het oog boven de horizon: Taalfiguren 3. Amsterdam: De Bezige Bij, 1995.

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Satō, Shūhō. Burakku Jakku ni yoroshiku: Gan iryō hen 3. Tōkyō: Kōdansha, 2003.

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Kare Kano: His And Her Circumstances: Volume 3. S.l: TokyoPop, 2003.

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Yangyao, Ou, ed. Kao ji jin hen zhuan 3 qian wan. Taibei Xian Xindian Shi: Zhi xuan gu fen you xian gong si, 2007.

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Bibliothek, Universität Tübingen. Het Tübingse Sint-Geertruihandschrift: Hs. Tübingen, Universitätsbibliothek, Me.IV.3. Hilversum: Verloren, 1996.

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Maruyama Masao to Yoshimoto Takaaki: Kaisōfū shisōron : hoka 3-hen. Tōkyō-to Chiyoda-ku: Sōeisha/Sanseidō Shoten, 2014.

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Book chapters on the topic "HEM-3"

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Elkobaisi, Mohammed R., Heinrich C. Mayr, and Vladimir A. Shekhovtsov. "Conceptual Human Emotion Modeling (HEM)." In Lecture Notes in Computer Science, 71–81. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-65847-2_7.

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Beelen, Frans, and Marianne Oelers. "3 Het materiaal." In Interactief, 29–40. Houten: Bohn Stafleu van Loghum, 2000. http://dx.doi.org/10.1007/978-90-313-9500-2_3.

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de Hosson, S. M., Y. P. de Jong, G. J. de Jonge, and M. J. Visser. "3 Het mediastinum." In De CT-thorax, 33–48. Houten: Bohn Stafleu van Loghum, 2015. http://dx.doi.org/10.1007/978-90-368-0366-3_3.

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van Halem, Nicolien, Carla van Herpen, and Marjan van Rooyen. "3 Het zorgleefplan." In Handboek EVV, 143–90. Houten: Bohn Stafleu van Loghum, 2010. http://dx.doi.org/10.1007/978-90-313-7674-2_3.

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van Halem, Nicolien, Carla van Herpen, and Marjan van Rooyen. "3 Het zorgleefplan." In Zakboek Zorgleefplan, 51–78. Houten: Bohn Stafleu van Loghum, 2010. http://dx.doi.org/10.1007/978-90-313-8383-2_3.

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Lange, M., and J. Wille. "3 Het bloedvatenstelsel." In Leerboek intensive-care-verpleegkunde, 263–308. Houten: Bohn Stafleu van Loghum, 2016. http://dx.doi.org/10.1007/978-90-368-1430-0_3.

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van de Ven, Y. "3 Het ondersteuningsplan." In Zorg voor de verstandelijk gehandicapte, 35–45. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-7536-3_3.

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Heres, Willeke, and Ineke van Steeg. "3 Het verzorgen van het bed." In Persoonlijke hygiëne, 28–45. Houten: Bohn Stafleu van Loghum, 2006. http://dx.doi.org/10.1007/978-90-313-9203-2_3.

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Siereveld, Geerard, Cees van Stipdonk, and Johan van ’t Wout. "3 Het verzorgen van het bed." In Persoonlijke hygiëne, 31–50. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-368-1097-5_3.

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Khan, Asif, Nadeem Javaid, Adnan Ahmed, Saqib Kazmi, Hafiz Majid Hussain, and Zahoor Ali Khan. "Efficient Utilization of HEM Controller Using Heuristic Optimization Techniques." In Advances in Internetworking, Data & Web Technologies, 573–84. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-59463-7_57.

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Conference papers on the topic "HEM-3"

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ADIGÜZEL, Ahmet. "ALİ BİN İSHAK’IN BÂHNÂMESİNDE FİİL ÇEKİMLERİ VE YAPILARI." In International Research Congress of Language and Literature of Language and Literature. Rmar Academy, 2021. http://dx.doi.org/10.47832/languagecongress978-605-065876-5.

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Bâh-nâmeler’in ana teması, konusu ve fikir yapısı, sağlıklı bir cinsellik, cinsel hastalıklar ve bu hastalıkların tedavisi için geleneksel çözüm arayışlarıdır. Bu eserler, içerdiği cinsel bilgilerin yanında ayrıca genel sağlık ve genel sağlıkla ilişkili olan bilim disiplinlerini de kapsayan birer genel sağlık ansiklopedileridir. Bāh-nāmeler, aslında geleneksel tedavi yöntemlerinin bilimsel tedavi yöntemlerine uyarlanmasıdır. Bu eserler, ayrıca cilt bakımı ve beden temizliğinin yaşam için gerekliliğini ve önemini de değerlendirmektedir. Genel ve cinsel sağlık alanlarında birçok bilim disiplinin malzemesini, unsurlarını barındıran bâh-nâmeler özellikle dil açısından da oldukça önemli ve zengin bir malzemeyle yazılmıştır. Bâh-nâmeler, Eski Türk dil unsurların yanında dil gelişim seyrini izleme açısından önemli eserler, kaynaklardır. Yaşam kalitesinin artması, ekonomik, sosyokültürel ilerlemeler, gelişmeler ve toplumsal değişimler konuşurların ölçünlü dillerinin ve dil gelişimine ve oluşmasına yardımcı olur. Teknoloji ve bilimde ilerleme, beraberinde bir dil zenginliği getirir. Fiiller, hareket, oluş, durum ve tavır bildiren yapılardır. Yapılan yeni icatlar, keşifler ve kullanılan yeni kavramlar, fiilleri daha işlevsel hale getirir ve cümlenin anlam yükünü taşıyan fiillerin çekimini daha önemli kılar. Türkçedeki kelimeler yapı, köken ve özellikleri bakımından üç temel birim olarak değerlendirilir: isimler, fiiller ve edatlar. Her ne kadar Banguoğlu ve Jean Deny gibi bazı dilbilimciler ünlem ve bağlaçları edattan ayrı yapılar olarak ele almışlarsa da Türk dilindeki kelime yapılarının tabii tasnifi açısından: 1. İsimler (Sıfatlar, zamirler ve zarflar) 2. Fiiller, 3. Edatlar (Bağlaçlar ve ünlemler) olarak üç ana bölümde toplanmaktadır. Türkçe fiil zengini bir dildir. Fiillerin haber ve dilek kipleri çekimleri ve bu zenginliği işlevsel hale getiren bir diğer husus fiil çekiminin esnekliğidir. Fiillerden türetilen fiilimsiler (Sıfat-fiil ve zar-fiiller cümle içerisinde geçici kelimeler üretir.) yüklem olarak kullanılabildiği gibi bir fiil çekime girdiğinde; fiilin kendisi, biçim ve zaman, şahıs unsurlarıyla çekimli fiil yapısını oluşturur. Çekimli fiiller cümlenin anlam bölümünü oluşturur. Fiil çekimi Türkçe cümle yapısında en az dört unsuru karşılar: hareket, biçim, zaman ve kişi. Cümlenin aslî unsuru olan çekimli fiil, tek başına cümlede ifade edilmek istenen anlamı taşıyabilir. Fiil çekimleri Türkçeye sonsuz anlam kazandırabilmektedir. Türkçede fiillerin yapıları incelendiğinde onları yapısal olarak da bir tasnife tabi tutmak gerekir: Kök fiiller, Türemiş fiiller ve Birleşik fiiller. Bu fiil yapıları da anlam içeriklerine göre farklılıklar teşkil etmektedirler: Hareket, iş oluş ve tavır bildirenler vd. Bâh-nâmede geçen fiiller tespit edilerek bu fiiller, hem çekimleri hem de yapıları bakımından incelendi
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Oates, William S., and Ralph C. Smith. "A Multi-Axial Electromechanically-Coupled Homogenized Energy Model for Ferroelectric Materials." In ASME 2017 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/smasis2017-3848.

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In this paper, we discuss the development and implementation of a 3-D electromechanically coupled homogenized energy model (HEM) for ferroelectric materials. A stochastic-based methodology is introduced and applied to problems involving large scale switching of ferroelectric and ferroelastic materials. Switching criteria for polarization variants are developed using density distributions in three dimensions to accommodate both electrical and mechanical loading and their coupled response. The theory accommodates non-proportional loading and major/minor loop hysteresis. Such formulations are known to accelerate computations for real-time control of nonlinear and hysteretic actuators. The proposed formulation maintains superior computational efficiency in the three dimensional case through the application of density formulations that are based on internal distributions of stress and electric field to produce a distribution of polarization switching events over a range of applied fields and stresses.
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Soler, Salvador. "ESTUDI DE LA DISTRIBUCIÓ DE QUALLAT EN DISTINTES SELECCIONS MASALS DE LA “TOMACA VALENCIANA D’EL PERELLÓ." In I CONGRÉS DE LA TOMACA VALENCIANA: LA TOMACA VALENCIANA DEL PERELLÓ. Valencia: Universitat Politècnica de València, 2017. http://dx.doi.org/10.4995/tomaval2017.2017.6523.

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En els últims anys, ha cobrat importància l'interès pel cultiu de les varietats tradicionals d’hortalisses. No obstant això, aquestes presenten una falta de estudis de caracterització i tipificació. Aquests són imprescindibles per detectar factors que dificulten la seua explotació, així com per emprendre programes de millora de les mateixes per augmentar la seva competitivitat i rendibilitat. En aquest treball s'han caracteritzat 3 poblacions de tomaca ‘Valenciana d’El Perelló’. L'objectiu ha estat obtenir informació fenotípica de rellevància en aquest tipus de tomaca. Aquesta informació està sent molt útil per a la seua millora genètica. Així, hem pogut constatar que les poblacions emprades de tomaca ‘Valenciana d’El Perelló’ es caracteritzen per presentar fruits del tipus “masclet” amb una freqüència elevada i un nivell productiu molt acceptable. La menor productivitat de les seleccions assajades en comparació amb el control comercial pareix ser deguda a una concentració de la producció en els 2-3 primers pomells de la planta; i una caiguda dràstica del quallat en els pomells superiors. No obstant, en el programa de selecció i millora de la tomaca ‘Valenciana d’El Perelló’ que s’està realitzant es disposa de seleccions amb una freqüència de masclets molta elevada y una distribució de quallat molt més uniforme.
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"HE2: environmental monitoring 3." In Proceedings of the 21st IEEE Instrumentation and Measurement Technology Conference. IEEE, 2004. http://dx.doi.org/10.1109/imtc.2004.1351500.

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Ladygin, V. P., T. Uesaka, T. Saito, M. Janek, A. S. Kiselev, A. K. Kurilkin, T. A. Vasiliev, et al. "Analyzing powers in the dd→[sup 3]Hen([sup 3]Hp) reactions at intermediate energies." In POLARIZED ANTIPROTON BEAMS - HOW: An International Workshop. AIP, 2008. http://dx.doi.org/10.1063/1.2932293.

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Bagge, L., E. Holmer, S. O. Nystroöm, H. Tydeén, and T. Wahlberg. "FRAGMIN VS HEPARIN AT RECYCLING OE HUMAN BLOOD IN HEART-LUNG MACHINE (HLM)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643042.

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During cardio-pulmonary bypass (CPB), Heparin inhibits EXa (EXal), thrombin and platelet activity and is also reported to induce fibrinolysis. Eragmin (Erag) has 25% thrombin inhibition capacity as related to that of Heparin (Hep). An in_vitro study was performed to compare Frag with Hep by circulating blood in a pure artificial system. In 20 experiments, 400 ml of freshly collected blood with Frag or Hep were recycled for 2 h. HLM was primed with 400 ml of Ringeracetate. Blood sampling: donor, blood pack and every 20 min from the oxygenator. V_a£i£ble£/jassay/:ACT/Hemochron/5 APTT , TT and NT/Nyegaard/;FXaI, FVIII and ATIiT t"ATA)/amydolytic/; AT 111 (ATAg) and vWF/IEP/;Plasminogen (Pig) and albumine/immuno-diffusion/;FDP/Wellcome/;Platelet function/Adeplat S/;Fibrinogen (Fbg)/clottable/;Hemolysis (HL)/photometric/; (β -Thromboglobulin ((βTG)/RTA/;EVF, Hb, platelet count (PC) and Leucocyte count (LC)/ conventional). Corrections for hemo-/plasma dilutions were calculated. Dosages (n): Frag: 750 (1), 1500 (3), 2100 (4), 2500 (4) FXal-U (U); Hep: 1000 (3), 1500 (6) IU clinical level. Clotting only occurred at Frag 750 (1) and 1500 (2) U, when ACT, APTT, FVIII, Fbg and ATA were significantly lowered. Generally, PC fell 75% during the recycling, while PF was constant'∼20% and (βTG increased. Neither presence of FDP nor Pig consumption were detected. FXal, ACT, APTT, TT and NT were dose dependent for both drugs. ATA was directly dose-related to Frag but inversely to Hep. LC decreased with the Frag-dose but inversely to that of Hep. HL increased generally. Several proteins increased (clotting excl): Fbg 30%, ATAg 25%, ATA 45?o and vWF 60%. Conclusions. Prevention of clotting required about the double dosage of Frag. Shortened ACT and APTT predicted clotting while the levels of FXal, TT and NT did not. Thus, an effective thrombin inhibition is needed under this conditions. Consumptions of FVIII, Fbg and ATA but no further drop in PC at clotting, indicate weak platelet aggregation involvement. Absence of fibrinolytic signs supports that the fibrinolysis seen at CPB, is not a genuine effect of Hep (or Frag). Increases in some proteins may be caused by cytolysis. The rise in vWF is probably due to release from platelet surfaces.
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Nasri, Abbas, Motahhareh Estebsari, Siroos Toofan, Anna Piacibello, Chiara Ramella, Vittorio Camarchia, and Marco Pirola. "A 3-3.8 GHz Class-J GaN HEMT Power Amplifier." In 2020 23rd International Microwave and Radar Conference (MIKON). IEEE, 2020. http://dx.doi.org/10.23919/mikon48703.2020.9253829.

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Rosemblit, Cinthia, Jashodeep Datta, Erik Berk, and Brian J. Czerniecki. "Abstract 1333: CD4 Th1 cytokines and HER-2/HER-3 blockade induces tumor apoptosis in breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1333.

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Gurpinar, Emre, and Alberto Castellazzi. "600 V normally-off p-gate GaN HEMT based 3-level inverter." In 2017 IEEE 3rd International Future Energy Electronics Conference and ECCE Asia (IFEEC 2017 - ECCE Asia). IEEE, 2017. http://dx.doi.org/10.1109/ifeec.2017.7992110.

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Rasidah, S., A. Rasmi, M. H. Siti Maisurah, A. I. A. Rahim, and M. R. Yahya. "3-stage 15 GHz p-HEMT power amplifier design for MMIC applications." In 2010 IEEE International Conference of Electron Devices and Solid- State Circuits (EDSSC). IEEE, 2010. http://dx.doi.org/10.1109/edssc.2010.5713755.

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Reports on the topic "HEM-3"

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Ram, Tracy G. Blocking HER-2-Mediated Transformation with a Dominant Form of HER-3. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada417299.

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Ram, Tracy G. Blocking HER-2-Mediated Transformation with a Dominant Negative Form of HER-3. Fort Belvoir, VA: Defense Technical Information Center, June 2001. http://dx.doi.org/10.21236/ada397167.

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Ram, Tracy G. Blocking HER-2-Mediated Transformation With a Dominant Negative Form of HER-3. Fort Belvoir, VA: Defense Technical Information Center, June 2002. http://dx.doi.org/10.21236/ada407503.

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McElroy, Robert Dennis. 3He Alternatives Summary Report. Office of Scientific and Technical Information (OSTI), November 2015. http://dx.doi.org/10.2172/1234989.

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Behringer, R. P., and J. Z. Larese. [Visualization of convection in {sup 3}He-superfluid-{sup 4}He]. Office of Scientific and Technical Information (OSTI), March 1995. http://dx.doi.org/10.2172/663251.

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Kaul, Ann. General Solution of the Kenamond HE Problem 3. Office of Scientific and Technical Information (OSTI), December 2015. http://dx.doi.org/10.2172/1233251.

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Sno, William Michael. Polarized 3He Neutron Spin Filters. Office of Scientific and Technical Information (OSTI), January 2016. http://dx.doi.org/10.2172/1234454.

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Lehman, e. Theory Of The HE-3 Electric Form-Factor. Office of Scientific and Technical Information (OSTI), June 2018. http://dx.doi.org/10.2172/1453921.

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Baumann, N. P., and G. P. Flach. Nuclear heating in He-3 fast SCRAM rods. Office of Scientific and Technical Information (OSTI), September 1989. http://dx.doi.org/10.2172/6975970.

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Tuggle, D. G., R. B. Schwarz, C. J. Maggiore, M. A. Neal, M. A. Whitcomb, H. T. Bach, and J. E. Vourinen. Measurement of He{sup 3} Formation in Pd. Office of Scientific and Technical Information (OSTI), July 1999. http://dx.doi.org/10.2172/763914.

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