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Journal articles on the topic 'Hematologic features'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Mody, Girish M., and Bilkish Cassim. "Rheumatologic features of hematologic disorders." Current Opinion in Rheumatology 8, no. 1 (1996): 57–61. http://dx.doi.org/10.1097/00002281-199601000-00011.

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2

Ehrenfeld, Michael, Hanan Gur, and Yehuda Shoenfeld. "Rheumatologic features of hematologic disorders." Current Opinion in Rheumatology 11, no. 1 (1999): 62–67. http://dx.doi.org/10.1097/00002281-199901000-00011.

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3

Hrycaj, Paweł, and Dorota Cieślak. "Hematologic features of systemic lupus erythematosus." Reumatologia/Rheumatology 1 (2013): 31–35. http://dx.doi.org/10.5114/reum.2013.33391.

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4

Zheng, J., Z. R. Dong, Y. P. Tang, et al. "AB0449 CLINICAL CHARACTERISTICS AND RISK FACTORS OF SYSTEMIC SCLEROSIS WITH HEMATOLOGIC SYSTEM DAMAGES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1252.1–1252. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3465.

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Background:SSc characterized by varying degrees of fibrosis of the skin and internal organs, clinicians pay more attention to skin and viscera conditions, tend to ignore hematologic system damage. Studies have shown that rheumatic disease such as SLE, RA, pSS often accompanied with hematologic system damages, and hematologic system damages is multiple organ involvement and risk factor of poor prognosis[1-2].Objectives:To investigate the the clinical features, laboratory characteristics and risk factors of Systemic Sclerosis (SSc) patient with hematologic system damages.Methods:The clinical dat

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Dutta, S. K., B. E. Penney, A. C. Myrup, M. G. Robl, and R. M. Rice. "Disease features in horses with induced equine monocytic ehrlichiosis (Potomac horse fever)." American Journal of Veterinary Research 49, no. 10 (1988): 1747–51. https://doi.org/10.2460/ajvr.1988.49.10.1747.

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SUMMARY Fifty-five horses were inoculated iv and/or sc with materials containing Ehrlichia risticii, ie, infected whole blood, bufly coat cells, or cell culture, to study clinical and hematologic features of equine monocytic ehrlichiosis (Potomac horse fever). Major clinical and hematologic features of induced E risticii infection were biphasic increase in rectal temperature with peak increases of 38.9 C and 39.3 C on postinoculation days (pid) 5 and 12, respectively; depression; anorexia; decreased wbc count (maximal decrease of 47% on pid 12); and diarrhea from pid 14 to pid 18. Increased wb

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Erber, Wendy N., and Jill Finlayson. "Hematologic Features of Hepatosplenic T-Cell Lymphoma." American Journal of Clinical Pathology 137, no. 2 (2012): 334–35. http://dx.doi.org/10.1309/ajcpvbi47qpvtjow.

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7

Cho, Joong-Yang. "A Practical Review of Paraproteinemic Neuropathy." Korean Journal of Neuromuscular Disorders 14, no. 2 (2022): 23–29. http://dx.doi.org/10.46518/kjnmd.2022.14.2.23.

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Paraproteinemic neuropathy is a heterogeneous set of neuropathies characterized by the presence of homogeneous immunoglobulin in the serum. Most cases are associated with monoclonal gammopathy of undetermined significance. It might also occur in hematologic malignant and nonmalignant conditions. The association between neuropathy and monoclonal gammopathy requires appropriate neurological and hematological investigations. Treatment is mostly based on underlying hematologic disorders. In this review, we provide a clinically practical approach to clinical, laboratory, electrophysiological featur

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Morin, D. E., F. B. Garry, M. G. Weiser, M. J. Fettman, and L. W. Johnson. "Hematologic Features of Iron Deficiency Anemia in Llamas." Veterinary Pathology 29, no. 5 (1992): 400–404. http://dx.doi.org/10.1177/030098589202900505.

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Iron deficiency anemia was identified and characterized in three 14 to 29-month-old male llamas (llama Nos. 1–3) from separate herds in Colorado. The identification of iron deficiency anemia was based on hypoferremia (serum iron = 20–60 μg/dl), erythrocytic features, and hematologic response to iron therapy. The anemia was moderate and nonregenerative and characterized by erythrocyte hypochromia, microcytosis (mean cell volume = 15–18 fl), and decreased mean corpuscular hemoglobin concentration (36.0–41.0 g/dl). Morphologic features unique to llamas with iron deficiency anemia included irregul

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9

Kwon, Chang Gyu, Yoo Nee Nam, Yong Han Sun, et al. "Hematologic Features of Children with Inflammatory Bowel Disease." Korean Journal of Pediatric Gastroenterology and Nutrition 12, no. 2 (2009): 171. http://dx.doi.org/10.5223/kjpgn.2009.12.2.171.

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10

Balaban, Daniel Vasile, Alina Popp, Florentina Ionita Radu, and Mariana Jinga. "Hematologic Manifestations in Celiac Disease—A Practical Review." Medicina 55, no. 7 (2019): 373. http://dx.doi.org/10.3390/medicina55070373.

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Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive cl

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Jakó, János, and László Szerafin. "Antepozíció testvérekben észlelt malignus hematológiai betegségekben. A 34 éves Szabolcs-Szatmár-Bereg megyei leukaemia/lymphoma regiszter adataiból levonható következtetések." Orvosi Hetilap 158, no. 33 (2017): 1283–87. http://dx.doi.org/10.1556/650.2017.30830.

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Abstract: Introduction: In their previous works, the authors reported findings from familial hematologic malignancies in Szabolcs-Szatmár-Bereg county, Hungary. So far there are no other studies on this topic available in Hungary. Aim: Detailed analysis of epidemiologic features of hematologic malignancies of siblings. Method: During a 34-year period (between January 1, 1983 and December 31, 2016), 86 families with hematologic malignancies were recorded in Szabolcs-Szatmár-Bereg county. Among them, 19 cases of the affected siblings were registered. Results: In one family there were three siste

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Pavri, Khorshed. "Clinical, Clinicopathologic, and Hematologic Features of Kyasanur Forest Disease." Clinical Infectious Diseases 11, Supplement_4 (1989): S854—S859. http://dx.doi.org/10.1093/clinids/11.supplement_4.s854.

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13

Ozbolat, Guluzar, and Abdullah Tuli. "Hematologic features of beta-globin gene mutation type (?o) with homozygous beta thalassemia." Ukrainian Biochemical Journal 90, no. 4 (2018): 115–20. http://dx.doi.org/10.15407/ubj90.04.115.

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14

Van Houten, D., M. G. Weiser, L. Johnson, and F. Garry. "Reference hematologic values and morphologic features of blood cells in healthy adult llamas." American Journal of Veterinary Research 53, no. 10 (1992): 1773–75. http://dx.doi.org/10.2460/ajvr.1992.53.10.1773.

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SUMMARY Hematologic values and cellular morphologic features were evaluated for 38 healthy adult llamas. Reference ranges were determined for pcv, reticulocyte concentration, leukocyte concentration, and leukocyte differential counts. The approach used in this study was to focus on hematologic values that may be determined by use of techniques readily available to the practicing veterinarian and nonveterinary laboratory. Unique cellular morphologic features commonly observed and interpreted as normal included large granular lymphocytes, hyposegmented eosinophil nuclei, folded erythrocytes, and

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15

Natelson, Ethan A. "Pregnancy-Induced Pancytopenia with Cellular Bone Marrow: Distinctive Hematologic Features." American Journal of the Medical Sciences 332, no. 4 (2006): 205–7. http://dx.doi.org/10.1097/00000441-200610000-00008.

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16

Clark, Julia, Makshada Kowlessur, Elysha VanderVeer, et al. "Hematologic malignancies masquerading as rheumatologic diseases: A case series and review." Medicine 104, no. 17 (2025): e42251. https://doi.org/10.1097/md.0000000000042251.

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Rationale: Hematologic malignancies can mimic rheumatologic diseases, presenting a significant diagnostic challenge due to overlapping clinical features. This study highlights 5 cases of hematologic malignancies presenting as rheumatologic disorders and discusses the diagnostic complexities involved. Patient concerns: The patients, aged 64 to 78, presented with diverse rheumatologic symptoms including polyarthritis, vasculitis, Raynaud phenomenon, and systemic symptoms such as weight loss, fatigue, and night sweats. Initial workups suggested rheumatologic diagnoses, leading to delays in recogn

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17

Guilbert, Marie-Christine, Jason L. Hornick, Sona A. Chikarmane, and Susan C. Lester. "Hematologic Malignancies of the Breast: A Contemporary Series Investigating Incidence, Presentation, Accuracy of Diagnosis on Core Needle Biopsy, and Hormone Receptor Expression." Breast Cancer: Basic and Clinical Research 13 (January 2019): 117822341983098. http://dx.doi.org/10.1177/1178223419830982.

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Background: Distinguishing breast hematologic malignancies in core needle biopsies from other entities can be challenging. Misclassification as a breast carcinoma could result in inappropriate treatment. The aim of this study was to characterize the types, incidence, and helpful diagnostic features of hematologic malignancies of the breast. Design: All hematologic malignancies of the breast diagnosed at our institution from 2004 to 2017 were identified. Clinical notes, imaging, and slides were reviewed. Immunohistochemical analysis of estrogen receptor α (ERα), estrogen receptor β (ERβ), and a

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18

Nguyen, Ngan, and Manjari Pandey. "Loxoscelism: Cutaneous and Hematologic Manifestations." Advances in Hematology 2019 (March 20, 2019): 1–6. http://dx.doi.org/10.1155/2019/4091278.

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Background. Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism. Methods. We retrospectively identified nine patients (pts) at our institution who were admitted with moderate to severe loxoscelism. A chart review was performed to highlight important clinical features and effect of interventions. Re

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19

YAEGASHI, HIROSHI, TAKAHIRO NOHARA, KAZUYOSHI SHIGEHARA, et al. "Survival Outcomes of Patients With Primary Mediastinal Germ Cell Tumors: A Retrospective Single-institutional Experience." Cancer Diagnosis & Prognosis 2, no. 3 (2022): 352–59. http://dx.doi.org/10.21873/cdp.10116.

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Background/Aim: Primary mediastinal non-seminomatous germ cell tumors (PMNSGCTs) are occasionally complicated by a hematologic malignancy, as with somatic-type malignant tumors called germ cell tumors with somatic-type malignancy (GCTSTM) and are known to have a poor prognosis. Patients and Methods: Data obtained between September 1997 and February 2020 for patients with mediastinal germ cell tumor at our institution were retrospectively analyzed. Key outcome measures included survival rates and the clinical features of non-seminoma cases. Results: Of 16 patients, 9 had pure seminoma, and 7 ha

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20

Salem, Ahmed Ebada, Harsh R. Shah, Matthew F. Covington, et al. "PET-CT in Clinical Adult Oncology: I. Hematologic Malignancies." Cancers 14, no. 23 (2022): 5941. http://dx.doi.org/10.3390/cancers14235941.

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PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging and evaluation of suspected recurrence. The goal of this 6-part series of review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for the more common adult malignancies. In the first article of this series, hematologic malignancies are addressed. The classification of these malignancies will be outlined, with the disclaimer that the classification of lymphomas is constantly evolving. Critical

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21

Dunn, John K., M. Fred Heath, Andrew R. Jefferies, Laura Blackwood, Jennifer S. McKay, and Philip K. Nicholls. "Diagnostic and Hematologic Features of Probable Essential Thrombocythemia in Two Dogs." Veterinary Clinical Pathology 28, no. 4 (1999): 131–38. http://dx.doi.org/10.1111/j.1939-165x.1999.tb01063.x.

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22

Kornyushina, E. A., and M. S. Zainulina. "P.63 Hematologic features of pregnant women with miscarriage and thrombophilia." Thrombosis Research 127 (February 2011): S144. http://dx.doi.org/10.1016/s0049-3848(11)70118-9.

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23

Myoken, Yoshinari, Tatsumi Sugata, Tai-Ichi Kyo, and Megumu Fujihara. "Pathologic features of invasive oral aspergillosis in patients with hematologic malignancies." Journal of Oral and Maxillofacial Surgery 54, no. 3 (1996): 263–70. http://dx.doi.org/10.1016/s0278-2391(96)90737-5.

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24

Paredes-Aguilera, Rogelio, Lina Romero-Guzman, Norma Lopez-Santiago, and Rosa Arana Trejo. "Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children." American Journal of Hematology 73, no. 2 (2003): 71–80. http://dx.doi.org/10.1002/ajh.10320.

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25

Dere, Özcan, and Yelda Dere. "The Impact of Hematologic Parameters on Histopathologic Features of Colorectal Cancer." International Journal of General Medicine Volume 17 (May 2024): 2029–36. http://dx.doi.org/10.2147/ijgm.s463588.

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26

Michelerio, Andrea, Marco Rubatto, Gabriele Roccuzzo, Marta Coscia, Pietro Quaglino, and Carlo Tomasini. "Eosinophilic Dermatosis of Hematologic Malignancy: Emerging Evidence for the Role of Insect Bites—A Retrospective Clinico-Pathological Study of 35 Cases." Journal of Clinical Medicine 13, no. 10 (2024): 2935. http://dx.doi.org/10.3390/jcm13102935.

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Background/Objectives: Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare cutaneous disorder associated with various hematologic malignancies, most commonly chronic lymphocytic leukemia. Detailed clinicopathologic studies of EDHM are lacking and the pathogenesis remains enigmatic. Initially thought to be a hypersensitivity reaction to insect stings, subsequent reports have challenged this understanding. The prognostic implications of EDHM remain unclear. Methods: A retrospective clinicopathologic study was performed on patients diagnosed with EDHM. Hematologic and dermatologic

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27

Rajabi-Moghaddam, Mahdieh, Gholamali Sarparast, and Hamid Abbaszadeh. "Bicytopenia Secondary to Autoimmune Myelofibrosis as the First Presentation of an Undiagnosed Systemic Lupus Erythematosus: A Rare Case Report." Journal of Advances in Medical and Biomedical Research 30, no. 139 (2022): 190–95. https://doi.org/10.30699/jambs.30.139.190.

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<strong>Abstract:</strong>   Autoimmune myelofibrosis (AIMF) is considered as an infrequent cause of bone marrow fibrosis (BMF) and a rare complication of systemic lupus erythematosus (SLE). Due to its rarity, it is mistakenly diagnosed as primary myelofibrosis (MF). We describe the clinicopathologic features of a secondary form of AIMF in a 33- year- old female patient with an undiagnosed SLE which presented with acute bicytopenia. Absence of splenomegaly, leukopenia, anemia, BMF (grade MF-1), and presence of autoantibodies were some of noticeable features. Treatment with corticoste

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Botero, Juliana Perez, and Jennifer Jury McIntosh. "Labor and delivery: DIC, HELLP, preeclampsia." Hematology 2023, no. 1 (2023): 737–44. http://dx.doi.org/10.1182/hematology.2023000500.

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Abstract Hematologists are often needed to assist with the management of microangiopathic emergencies in pregnancy. A firm understanding of the diagnosis and management of preeclampsia with severe features, hemolysis elevated liver enzyme and low platelet syndrome, and disseminated intravascular coagulation, which are the most common causes of microangiopathic emergencies, is critical. However, being able to consider when other microangiopathic emergencies (acute fatty liver of pregnancy, congenital and acquired thrombotic thrombocytopenic purpura, complement mediated microangiopathy, antiphos

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Tritipsombut, Jaruwan, Kanokwan Sanchaisuriya, Supan Fucharoen та ін. "Hemoglobin Profiles and Hematologic Features of Thalassemic Newborns: Application to Screening of α-Thalassemia 1 and Hemoglobin E". Archives of Pathology & Laboratory Medicine 132, № 11 (2008): 1739–45. http://dx.doi.org/10.5858/132.11.1739.

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Abstract Context.—Thalassemia and hemoglobinopathies are major public health problems worldwide. To establish a cost-effective screening tool for newborns in regions where the incidence of these disorders is significant, study of the hemoglobin and hematologic features of normal and thalassemic newborns is necessary. Objective.—To study hemoglobin and hematologic characteristics of normal and various thalassemic newborns and to assess the effectiveness of simple screening methods for α-thalassemia 1 and hemoglobin E. Design.—Study was made of 402 cord blood specimens collected from unrelated T

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Ogbera, Okeoghene A., Eregie Osa, Andrew Edo, and Ekebegh Chukwum. "Common Clinical Features of Diabetic Foot Ulcers: Perspectives From a Developing Nation." International Journal of Lower Extremity Wounds 7, no. 2 (2008): 93–98. http://dx.doi.org/10.1177/1534734608318236.

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Foot ulceration is a prominent cause of diabetes mellitus morbidity and mortality in developing countries. This is an observational study in which 47 consecutive diabetes mellitus patients with foot ulcers were studied over a 2-year period. Each patient's medical history, physical examination findings, and hematological and radiological features were documented. The mean age of the patients was 56 (11) years. The majority of the patients (40, 85%) had type 2 diabetes mellitus; 25% of patients with type 2 diabetes mellitus were diagnosed when they presented with foot ulceration. Grades 2 and 3

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Shahramian, Iraj, Kaveh Tabrizian, Mojtaba Delaramnasab, et al. "A Review on Clinical, Pathophysiological, and Diagnostic Hematological Features in Children With Liver Cirrhosis." International Journal of Basic Science in Medicine 4, no. 3 (2019): 86–95. http://dx.doi.org/10.15171/ijbsm.2019.17.

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Appropriate diagnostic and therapeutic measures for liver cirrhosis is critical, particularly in children. In the present review, a comprehensive approach was provided toward hematological parameters in pediatric liver cirrhosis. The literature search included MeSH terms "liver cirrhosis" and "hepatic cirrhosis" and databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched up until December 2017. Hematologic changes in the liver cirrhosis mainly encompassed anemia and coagulopathies. In addition, bleeding diathesis was considered as the most clinical complication in th

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32

Hong, Youngtaek, Seri Jeong, Min-Jeong Park, Wonkeun Song, and Nuri Lee. "Application of Pathomic Features for Differentiating Dysplastic Cells in Patients with Myelodysplastic Syndrome." Bioengineering 11, no. 12 (2024): 1230. https://doi.org/10.3390/bioengineering11121230.

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Myelodysplastic syndromes (MDSs) are a group of hematologic neoplasms accompanied by dysplasia of bone marrow (BM) hematopoietic cells with cytopenia. Recently, digitalized pathology and pathomics using computerized feature analysis have been actively researched for classifying and predicting prognosis in various tumors of hematopoietic tissues. This study analyzed the pathomic features of hematopoietic cells in BM aspiration smears of patients with MDS according to each hematopoietic cell lineage and dysplasia. We included 24 patients with an MDS and 21 with normal BM. The 12,360 hematopoieti

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Goksu, Hamit. "Evaluation of Patients with Solid and Hematological Malignancies Referred to the Pain Department in an Oncology Branch Hospital." Journal of Anesthesiology and Reanimation Specialists' Society 33, no. 2 (2025): 111–18. https://doi.org/10.54875/jarss.2025.88156.

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Objective: It is aimed to investigate pain and pain-associated clinical factors in patients with solid and hematological cancers referred to the pain department. Methods: The study included patients referred to the pain department due to cancer pain. The demographic and clinical features, type of pain, visual analog scale (VAS) scores, and 6-month survival data were evaluated. Results: The median VAS score of the patients was 7.0. The Vas score did not significantly differ between solid and hematological malignancies (p=0.149). The World Health Organization analgesic ladder was 2 or 3 for almo

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Mirabilii, Simone, Maria Rosaria Ricciardi, and Agostino Tafuri. "mTOR Regulation of Metabolism in Hematologic Malignancies." Cells 9, no. 2 (2020): 404. http://dx.doi.org/10.3390/cells9020404.

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Neoplastic cells rewire their metabolism, acquiring a selective advantage over normal cells and a protection from therapeutic agents. The mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase involved in a variety of cellular activities, including the control of metabolic processes. mTOR is hyperactivated in a large number of tumor types, and among them, in many hematologic malignancies. In this article, we summarized the evidence from the literature that describes a central role for mTOR in the acquisition of new metabolic phenotypes for different hematologic malignancies, in conc

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35

Frater, John L., Tianjiao Wang, and Yi-Shan Lee. "Laboratory hematologic features of COVID-19 associated liver injury: A systematic review." World Journal of Meta-Analysis 9, no. 2 (2021): 192–206. http://dx.doi.org/10.13105/wjma.v9.i2.192.

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Frater, John L., Tianjiao Wang, and Yi-Shan Lee. "Laboratory hematologic features of COVID-19 associated liver injury: A systematic review." World Journal of Meta-Analysis 9, no. 2 (2021): 193–207. http://dx.doi.org/10.13105/wjma.v9.i2.193.

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Klimkovich, N. "P004 Clinico-hematologic and prognostic features of myelodysplastic syndromes of children inBelarus." Leukemia Research 31 (May 2007): S42—S43. http://dx.doi.org/10.1016/s0145-2126(07)70074-7.

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38

Stover, Susan M., Eugene P. Steffey, Nöel O. Dybdal, and Charles E. Franti. "Hematologic and serum biochemical alterations associated with multiple halothane anesthesia exposures and minor surgical trauma in horses." American Journal of Veterinary Research 49, no. 2 (1988): 236–41. https://doi.org/10.2460/ajvr.1988.49.02.236.

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SUMMARY Five horses were anesthetized similarly by use of xylazine, guaifenesin, thiamylal sodium, and halothane in oxygen on 3 consecutive days, and minor surgical procedures were performed. For 1 to 10 days after the last anesthetic exposure, clinical, hematologic, and serum biochemical features were monitored, and after necropsy, histologic examination of major organ tissues was performed. Predominant hematologic changes from base-line values included leukocytosis (maximal at 27 hours, 10,500 ± 1,750 cells/μl), neutrophilia (maximal at 51 hours, 7,485 ± 1,719 cells/μl), and lymphopenia (min

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Wang, Jinuo, Hui Fu, Bangcheng Ye, Wenjun Wu, and Jian Yu. "Clinical Features and Prognosis of Behcet's-like Syndrome in Myeloid Neoplasms with or without Trisomy 8." Blood 144, Supplement 1 (2024): 6738. https://doi.org/10.1182/blood-2024-203155.

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Introduction Behçet disease, a specific form of systemic vasculitis, is associated with an increased risk of malignancy, particularly hematological malignancies. There is a noted correlation between gastrointestinal involvement in Behçet-like syndrome (BS), MDS/AML, and trisomy 8, though the exact mechanism remains unclear. This is thought to be related to genetic susceptibility and immune system abnormalities. This study aims to examine the clinical features and long-term outcomes of patients with hematological malignancies complicated by BS, and to assess the effect of trisomy 8 mutations on

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40

Bhaskar, Das, Mal Parihar Puran, Kumar Choudary Mahesh, Mamta, and Tak Amit. "Comparing Clinical and Hematologic Outcomes in Hypertensive and Non-Hypertensive Patients Suffering from COVID-19." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 649–52. https://doi.org/10.5281/zenodo.12670221.

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<strong>Introduction:</strong> Hypertension is the most common co-morbidity associated with COVID-19  patients. Many patients take angiotensin-converting enzyme (ACE) inhibitors for the management of hypertension.  The study aimed to compare the clinical and hematologic features in hypertensive and non-hypertensive patients suffering from COVID-19. <strong>Material and Methods:</strong> This observational study compared clinical and hematologic features in hypertensive and non-hypertensive patients suffering from COVID-19. The study enrolled patients from SMS Medical C

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Pudasainee, Prasun, Bimatshu Pyakuryal, Yogesh Subedi, Jenisha Upadhyay, and Subarna Adhikari. "Extramedullary Manifestations of Chronic Myelomonocytic Leukemia: Do We Treat like an Acute Myeloid Leukemia?" Case Reports in Hematology 2019 (November 30, 2019): 1–4. http://dx.doi.org/10.1155/2019/8360454.

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Chronic myelomonocytic leukemia (CMML) is a relatively rare clonal hematologic disorder with features of myelodysplastic syndrome and myeloproliferative disease. Extramedullary leukemic involvement is rarely a presenting feature of CMML. As there are no clear guidelines in regard to the treatment of patients with extramedullary manifestations, its management is challenging. In this report, we discuss the management of our patient who presented with submandibular lymphadenopathy and gingivitis and was diagnosed with CMML.

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Pak, Daniel M., and Maria S. Tretiakova. "An Unusual Manifestation of Blastic Plasmacytoid Dendritic Cell Neoplasm as a Testicular Tumor." Case Reports in Pathology 2019 (October 7, 2019): 1–4. http://dx.doi.org/10.1155/2019/9196167.

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive hematologic malignancy arising from precursors of plasmacytoid dendritic cells that represent less than 1% of hematological malignancies. BPDCN initially presents with cutaneous involvement and a characteristic immunophenotype of CD4, CD56, and CD123 co-expression. Upon disease progression, BPDCN shows a strong predilection for bone marrow, peripheral blood, and lymph nodes, whereas manifestations in visceral organs are rare. Significant heterogeneity in clinical presentation and immunophenotypic profile makes BPDC

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Tsilingiris, Dimitrios, Narjes Nasiri-Ansari, Nikolaos Spyrou, Faidon Magkos, and Maria Dalamaga. "Management of Hematologic Malignancies in the Era of COVID-19 Pandemic: Pathogenetic Mechanisms, Impact of Obesity, Perspectives, and Challenges." Cancers 14, no. 10 (2022): 2494. http://dx.doi.org/10.3390/cancers14102494.

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The COVID-19 pandemic brought about an unprecedented societal and healthcare system crisis, considerably affecting healthcare workers and patients, particularly those with chronic diseases. Patients with hematologic malignancies faced a variety of challenges, pertinent to the nature of an underlying hematologic disorder itself as well as its therapy as a risk factor for severe SARS-CoV-2 infection, suboptimal vaccine efficacy and the need for uninterrupted medical observation and continued therapy. Obesity constitutes another factor which was acknowledged since the early days of the pandemic t

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San Miguel, JF, M. Gonzalez, MC Canizo, et al. "Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics." Blood 72, no. 2 (1988): 402–7. http://dx.doi.org/10.1182/blood.v72.2.402.402.

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Abstract The clinical, hematologic, and phenotypic features of 28 patients with acute leukemia with megakaryocytic involvement (AMKL) were analyzed. The prevalence of this type of leukemia in the entire series was 11.6%, with a higher incidence among patients with acute transformation of a previous myeloproliferative disorder (MPD) (24%) than among the transformed myelodysplastic syndrome (13%) patients. The incidence in the “de novo” ANLL was 8% and 16% among secondary leukemias. The presence of bone marrow fibrosis together with low WBC and normal or increased platelet counts despite a sever

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San Miguel, JF, M. Gonzalez, MC Canizo, et al. "Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics." Blood 72, no. 2 (1988): 402–7. http://dx.doi.org/10.1182/blood.v72.2.402.bloodjournal722402.

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Abstract:

The clinical, hematologic, and phenotypic features of 28 patients with acute leukemia with megakaryocytic involvement (AMKL) were analyzed. The prevalence of this type of leukemia in the entire series was 11.6%, with a higher incidence among patients with acute transformation of a previous myeloproliferative disorder (MPD) (24%) than among the transformed myelodysplastic syndrome (13%) patients. The incidence in the “de novo” ANLL was 8% and 16% among secondary leukemias. The presence of bone marrow fibrosis together with low WBC and normal or increased platelet counts despite a severe anemia

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Li, Peng, Shobi Venkatachalam, Daniela Ospina Cordona, et al. "A clinical, histopathological, and molecular study of two cases of VEXAS syndrome without a definitive myeloid neoplasm." Blood Advances 6, no. 2 (2022): 405–9. http://dx.doi.org/10.1182/bloodadvances.2021005243.

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Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by somatic mutations in UBA1 and is identified by a genotype-driven method. This condition affects unrelated men with adultonset inflammatory syndromes in association with hematologic manifestations of peripheral cytopenia and bone marrow myeloid dysplasia. Although bone marrow vacuolization restricted to myeloid and erythroid precursors has been identified in patients with VEXAS, the detailed clinical and histopathological features of peripheral blood and bone marrows remain unclear. The current case

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Carty, Shannon A. "Immunology 101: fundamental immunology for the practicing hematologist." Hematology 2021, no. 1 (2021): 281–86. http://dx.doi.org/10.1182/hematology.2021000260.

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Abstract From an evolutionary perspective, the immune system developed primarily to protect the host from pathogens. In the continuous balance between killing pathogens and protecting host tissues, selective pressures have shaped the discriminatory functions of the immune system. In addition to protection against microbial pathogens, the immune system also plays a critical role in antitumor immunity. Immune dysfunction, either under- or overactivity, is found in a wide range of hematologic disorders. Here we review the fundamental features of the immune system and the key concepts critical to

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Meirina, Fathia, Bidasari Lubis, Tiangsa Sembiring, Nelly Rosdiana, and Olga Siregar. "Hematological scoring system as an early diagnostic tool for neonatal sepsis." Paediatrica Indonesiana 55, no. 6 (2016): 315. http://dx.doi.org/10.14238/pi55.6.2015.315-21.

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Background Sepsis was the leading cause of death in babies by30%-50% in developing countries. Early diagnosis of neonatalsepsis is still a difficult problem because of clinical features are notspecific. Blood culture is the gold standard, but it takes several daysand is expensive. The hematological scoring system (HSS) consistsof hematologic parameters (leucocyte count, polymorphonuclear(PMN) cells, degenerative changes, and platelet count) for earlydiagnosis of neonatal sepsis.Objective To measure HSS as an early diagnostic tool for neonatalsepsis.Methods A cross sectional study was conducted

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Craig, Fiona E., and Kenneth A. Foon. "Flow cytometric immunophenotyping for hematologic neoplasms." Blood 111, no. 8 (2008): 3941–67. http://dx.doi.org/10.1182/blood-2007-11-120535.

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Abstract Flow cytometric immunophenotyping remains an indispensable tool for the diagnosis, classification, staging, and monitoring of hematologic neoplasms. The last 10 years have seen advances in flow cytometry instrumentation and availability of an expanded range of antibodies and fluorochromes that have improved our ability to identify different normal cell populations and recognize phenotypic aberrancies, even when present in a small proportion of the cells analyzed. Phenotypically abnormal populations have been documented in many hematologic neoplasms, including lymphoma, chronic lymphoi

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Yoon, Dan, Bita Jafarzadeh, Vahid Mehrtash, et al. "Self-Supervised Learning Based Characterization of Bone Marrow Biopsies for Enhanced Diagnosis of Hematologic Disorders." Blood 144, Supplement 1 (2024): 2234. https://doi.org/10.1182/blood-2024-210945.

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Background Morphologic evaluation of bone marrow biopsies (BMBx) to diagnose hematologic malignancies and disorders can be challenging due to limitations in cytologic details. With the increasing interest of applying AI in pathology, significant focus has been placed on utilizing machine learning to enhance diagnostic precision. Many of these studies have focused on distinguishing diseases within the same or limited diagnostic categories, but it is unclear if these methods can identify disease processes across a diversity of hematologic disorders solely based on bone marrow histology alone. To

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