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Dissertations / Theses on the topic 'Hematology-oncology'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Maxfield, Melissa D. "Hematology/Oncology Unit Champions Promote Care Plans for CLABSI Prevention." Mount St. Joseph University Dept. of Nursing / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=msjdn1619082600353203.

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2

Thomas, C. M., and John B. Bossaer. "Patient Use of Herbal Supplements in an Outpatient Hematology/Oncology Medical Clinic." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2356.

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Primary Objective: According to the National Center for Health Statistics, many Americans use some type of vitamin or supplement. A recent study of cancer patients in the VA medical system found that a significant number of cancer patients do not mention the use of supplements to their healthcare providers. Many of these supplements were also found to interact with or compound side effects of chemotherapy regimens. The purpose of this study is to determine the incidence of cancer patients taking supplements and to determine the completeness of home medication lists in regard to vitamins or her

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3

Soell, Kurt D. "Spirituality and Depression in Parents with Children in Oncology or Hematology Treatment." ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/938.

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The psychological burden of cancer treatment affects not only child patients but also their parents. There is extensive literature on the positive influence of spirituality on the cancer patient. But there is a gap in the literature on the potential healing influence of spirituality on the parent of the cancer or hematology patient. The purpose of this study was to examine the relationship between spirituality and parents' levels of depression and anxiety during their child's hematological or oncology treatment. Using the transtheoretical model of change, a purposive sample of 48 parents of

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4

Tawadros, Fady, and Kanishka Chakraborty. "Systemic Mastocytosis with associated CMML." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/75.

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Systemic mastocytosis refers to a heterogeneous group of clinical disorders characterized by excessive mast cell accumulation in one or multiple organs. Mastocytosis is now considered as a separate disease category in the 2016 WHO classification of myeloid neoplasm and acute leukemia. It is no longer considered as a subgroup of meyloproliferate neoplasms. The clinical presentation of mastocytosis is heterogeneous ranging from skin-limited disease (cutaneous mastocytosis) to a more aggressive form with extra cutaneous presentation (systemic mastocytosis) with or without skin involvement. We ar

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5

REDDY, DHEERAJ MD, Fady MD Tawadros, Archi MD Patel, and Devapiran MD Jaishankar. "RENAL AND TESTICULAR MYELOID SARCOMA DEFINES ACUTE MYELOID LEUKEMIA EVEN IN THE ABSENCE OF BLOOD AND MARROW INVOLVEMENT." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/211.

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Acute Myeloid Leukemia (AML) is an aggressive hematopoietic neoplasm characterized by rapid clinical progression and universally fatal outcome if left untreated. The neoplastic cells are immature precursor cells that usually originate in the bone marrow and are often noted in the peripheral circulation. Myeloid sarcomas are rare abnormal collection of these cells in extramedullary sites and are now defined as a unique subset of AML as per the WHO classification. Here we describe a patient with AML presenting with a renal and testicular mass, which on biopsy revealed myeloid sarcoma in the abse

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6

Singal, Sakshi, Rossa Khalaf, Sara Masood, and Devapiran Jaishankar. "BURKITT’S LYMPHOMA MASQUERADING AS ACUTE CHOLECYSTITIS AND VAGINAL BLEEDING." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/11.

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Burkitt lymphoma is a highly aggressive B cell non-Hodgkin lymphoma characterized by the translocation t(8,14) and deregulation of the MYC gene on chromosome 8. The endemic (African) form presents classically as an expanding mass in the jaw. The nonendemic (European/North American) form often presents with an abdominal mass. We present an interesting case of Burkitt’s Lymphoma with atypical features. A thirty-five-year-old lady with no significant medical history presented to the hospital with a three week complaint of vaginal bleeding and lower abdominal pain/cramps associated with night swea

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7

Montanari, Pierre. "Étude des kinases PIMs dans l’érythropoïèse normale et pathologique." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB094.

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L’érythropoïèse désigne l’ensemble des phénomènes de prolifération et de maturation qui permettent d’obtenir les globules rouges à partir de cellules souches médullaires. C’est un processus de différenciation continue qui génère des cellules érythroïdes de plus en plus matures. L’érythropoïétine (EPO) est le principal régulateur de l’érythropoïèse. En effet, il est indispensable à la survie et à la prolifération des progéniteurs érythroïdes et des précurseurs érythroblastiques. Le rôle des Pims kinases dans la régulation de l'érythropoïèse n’a pas été étudié bien qu’il ait été montré que les s

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8

Vedantam, Venkata Sri Harsha, Neethu Nair, CHRISTINE MOORE, and Diana Gorman-Nunley. "VITAMIN B12 DEFICIENCY ANEMIA-ASSOCIATED MALIGNANCY ACCELERATED BY SUPPLEMENTATION." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/49.

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Vitamin B12 and folate are necessary for bone marrow progenitor growth and division. Deficiencies are common in lymphoproliferative disorders due to increased demands of rapidly growing malignant cells. Isolated vitamin B12 deficiency is seen in 13% of these patients and may be their only manifestation. We present the case of vitamin B12 deficiency anemia due to an underlying malignancy that was discovered following supplementation. A 77-year-old nonsmoker female with chronic kidney disease and hypothyroidism presented to her internist with dyspnea, tachycardia and unintentional 7-pound weight

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9

Schäfer, Louisa [Verfasser], Jutta [Gutachter] Hübner, Michael [Gutachter] Hartmann, and Franz-Josef [Gutachter] Prott. "Potential interactions of medication prescribed in discharge letters from a clinic for hematology and oncology / Louisa Schäfer ; Gutachter: Jutta Hübner, Michael Hartmann, Franz-Josef Prott." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1218595663/34.

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10

Singh, Kanwardeep, Vindhya Sriramoju, Sakshi Singal, Elnora N. Spradling, and Rabia Zafar. "A case of Progressive Glomerulonephritis with Monoclonal Immunoglobulin Lambda Light Chain Deposition (LCDD)." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/77.

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Light Chain Deposition Disease (LCDD) is a type of monoclonal immunoglobulin deposition disease characterized by the non-amyloid deposition of monoclonal light chains in the tubular basement membranes and Bowman’s capsule. It was first described about 3 decades ago, but due to varied clinical presentations, many differential diagnoses and low incidence, it is both underrecognized and underreported. We present a case of 85-year-old female with past medical history significant for CKD and HTN, who presented with accelerated HTN, normocytic anemia and worsening renal function. Laboratory data sho

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11

Williams, Heather Elizabeth. "Integrative Molecular Pathological Epidemiology of Congenital and Infant Acute Leukemia." Diss., NSUWorks, 2019. https://nsuworks.nova.edu/hpd_hs_stuetd/13.

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Congenital and infant acute leukemia remain one of the most puzzling clinical issues in pediatric hematology-oncology. There is a paucity of studies focused on these rare, aggressive, acute leukemias; specifically, there is little study on the differences in disease in the youngest of infants less than 1 year of age unlike the numerous studies of the disease in older children. The United States National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) cancer population registry program has been integral for a plethora of clinical population and pathology research studies f

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12

Ribera, Cortada Inmaculada. "Papel del factor de transcripción SOX11 en la caracterización del linfoma de células del manto." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/400827.

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El Linfoma de células del Manto (LCM) es un linfoma B maduro, con una característica sobreexpresión de la proteína nuclear Ciclina D1. Se caracteriza por presentar un curso clínico agresivo, aunque se ha observado que algunos pacientes tienen un curso clínico más indolente. Recientemente se ha observado que el factor de transcripción SOX11 tiene una sobreexpresión específica en este tipo de linfoma. El diagnóstico diferencial entre el LCM y otros tipos de linfoma B puede ser difícil. Un problema es el diagnostico diferencial entre el Linfoma Difuso de Célula B Grande (LDCBG) Ciclina D1 posi

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13

Tokarski, Robert James II. "The 20S Proteasome as a Target for Novel Cancer Therapeutics: Development of Proteasome Inhibitors and Proteolysis-Targeting Chimeras (PROTACs)." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587559789211309.

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14

Graham, Emily Nicole. "Optimizing Care for Oncologic and Hematologic Patients with Febrile Neutropenia." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1483522367955844.

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15

Català, i. Temprano Albert. "Caracterització de les alteracions moleculars de FLT3 en pacients pediàtrics afectes de leucèmia aguda. Correlació amb l’activitat i expressió dels transportadors de fàrmacs derivats de nucleòsids." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/403756.

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Treball 1: Caracterització de les diferents alteracions de FLT3 en LLA i LMA en una sèrie de pacients pediàtrics: incidència, impacte pronòstic i correlació amb altres variables clínico-biològiques En aquest treball s’analitza l’estat mutacional i nivell d’expressió en mostres de 204 pacients pediàtrics afectes de diferents subtipus de leucèmia aguda (LLA-B: 144; LLA-T: 23; LMA: 36 i una MPAL), uniformement tractats en el nostre centre segons protocols de la Sociedad Española de Hematología y Oncología Pediátricas (SEHOP). A més de la caracterització de l’estat de FLT3 també vam analitzar

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16

Kozlowski, Piotr. "Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-47424.

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Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records. I. We assessed ALL relapse treatment and outcome in 76 patients aged 15-65 years (y). Complete remission (CR) was achieved in 50/71 patients (70%). Of them, 29 underwent allogeneic hematopoietic stem cell transplantation (hSCT). Five year overall survival (OS) was 15%, but close to 50% in 19 patients <35y after hSCT. II. We studied outcom

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17

Melo, H?nia Ramalho de. "Biosseguran?a e a sa?de do trabalhador na assist?ncia a pacientes em tratamento onco-hematol?gico." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14753.

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Made available in DSpace on 2014-12-17T14:46:54Z (GMT). No. of bitstreams: 1 HeniaRM_DISSERT.pdf: 737264 bytes, checksum: 659ba1c33d2c3466055d007e670761c6 (MD5) Previous issue date: 2011-12-20<br>In recent years, the biosafety has been made possible a new look which are based the conceptions of health and illness process, as well as human needs. This new vision is focused on health vigilance that is referenced specifically in this study to the worker s health. The health of workers is essential for the prevention and control of epidemics and outbreaks of diseases as well as emerging and reem

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18

Young, Emma. "Recurrent Genetic Mutations in Lymphoid Malignancies." Doctoral thesis, Uppsala universitet, Experimentell och klinisk onkologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314956.

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In recent years, the genetic landscape of B-cell derived lymphoid malignancies, including chronic lymphocytic leukemia (CLL), has been rapidly unraveled, identifying recurrent genetic mutations with potential clinical impact. Interestingly, ~30% of all CLL patients can be assigned to more homogeneous subsets based on the expression of a similar or “stereotyped” B-cell receptor (BcR). Considering that biased distribution of genetic mutations was recently indicated in specific stereotyped subsets, in paper I, we screened 565 subset cases, preferentially assigned to clinically aggressive subsets,

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19

Slind, Olsen Renate. "Circulating and genetic factors in colorectal cancer : Potential factors for establishing prognosis?" Doctoral thesis, Linköpings universitet, Avdelningen för läkemedelsforskning, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136841.

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Colorectal cancer (CRC) is defined as a cancer appearing in the colon or in the rectum. In Sweden, ~ 6300 individuals were diagnosed with the disease in 2014 and ~ 2550 individuals diagnosed with CRC die each year due to their cancer. Surgery is the main treatment option of CRC and a survival rate of ~ 10 % is estimated if distant metastases have developed. It is therefore of importance to find factors that may be useful together with tumour, node, metastasis (TNM) stage to establish early CRC diagnosis, prognosis and follow-up of CRC patients. The aim of this thesis was to study the possible

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20

Recasens, Zorzo Clara. "Preclinical evaluation of the antitumor activity of a new CXCR4 inhibitor: a novel therapeutic approach in diffuse large B-cell lymphoma." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663897.

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Constitutive activation of the chemokine receptor CXCR4 is associated with tumor progression, invasion and resistance to treatment. Overexpression of CXCR4 in diffuse large B-cell lymphoma (DLBCL) confers a reduced prognosis. However, the biological relevance of this receptor in DLBCL progression remains underexplored. In this thesis, the new CXCR4 inhibitor IQS-01.01 has been preclinicaly evaluated in in vitro and in vivo models of DLBCL. It has been concluded that 1) inhibition of CXCR4 presents antitumor properties in DLBCL, 2) that IQS-01.01RS holds better pharmacological properties than t

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21

Banús, Mulet Antònia. "Disrupció de l’homeòstasi lipídica com estratègia terapèutica en leucèmia limfoblàstica aguda -T." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667432.

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Recentment s’han descrit els receptors de dopamina per la seva implicació en càncer i la seva potencial inhibició com a mecanisme antitumoral. Al present treball s’ha ampliat aquesta recerca a la LLA-T, una malaltia amb recaigudes freqüents i mal pronòstic en pacients adults, i on existeix la necessitat de tractaments innovadors. Aquí, es descriuen els efectes antileucèmics selectius de L741-742, nemonaprida i RBI-257, tots ells antagonistes del receptor de dopamina tipus 4 (DRD4), al rang micromolar baix, validats en experiments en línies cel·lulars i amb una mostra primària en experiments ex

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22

Esteve, Arenys Anna. "Innovative targeted therapies for chemorefractory B-cell non-Hodgkin lymphomas." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565937.

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Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are afflicted by lymphomas of B-cell origin. The current World Health Organization (WHO) classification of hematopoietic and lymphoid tumors categorizes B-cell neoplasms in more than 40 distinct disease entities, according to a combination of the morphology, immunophenotype, genetic, molecular and clinical features. Each entity has its own clinical course and requires specific treatments. The chara

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23

Daniel, Peter. "Deregulation von Zellzyklus und Apoptose als molekulare Grundlage der Therapieresistenz von Tumoren." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=968783066.

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24

Xue, Liting. "Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/740.

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The CBFbeta-SMMHC fusion protein is expressed in acute myeloid leukemia (AML) samples with the chromosome inversion inv(16)(p13;q22). This fusion protein binds the transcription factor RUNX with higher affinity than its physiological partner CBFbeta and disrupts the core binding factor (CBF) activity in hematopoietic stem and progenitor cells. Studies in the Castilla laboratory have shown that CBFbeta-SMMHC expression blocks differentiation of hematopoietic progenitors, creating a pre-leukemic progenitor that progresses to AML in cooperation with other mutations. However, the combined function

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25

Xue, Liting. "Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/740.

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The CBFbeta-SMMHC fusion protein is expressed in acute myeloid leukemia (AML) samples with the chromosome inversion inv(16)(p13;q22). This fusion protein binds the transcription factor RUNX with higher affinity than its physiological partner CBFbeta and disrupts the core binding factor (CBF) activity in hematopoietic stem and progenitor cells. Studies in the Castilla laboratory have shown that CBFbeta-SMMHC expression blocks differentiation of hematopoietic progenitors, creating a pre-leukemic progenitor that progresses to AML in cooperation with other mutations. However, the combined function

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26

Kaymaz, Yasin. "Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/914.

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Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Despite this increased burden the study of eBL has lagged. Additionally, while EBV was isolated from an African Burkitt lymphoma tumor 50 years ago, however, the impact of viral variation in oncogenesis is just beginning to be fully explored. In my thesis research, I focused on investigating molecular genetics of the endemic form of this lymph

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27

Kaymaz, Yasin. "Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/914.

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Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Despite this increased burden the study of eBL has lagged. Additionally, while EBV was isolated from an African Burkitt lymphoma tumor 50 years ago, however, the impact of viral variation in oncogenesis is just beginning to be fully explored. In my thesis research, I focused on investigating molecular genetics of the endemic form of this lymph

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28

Vegliante, Maria Carmela. "SOX11 transcription factor functional analysis in aggressive MCL." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/293896.

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Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified as a very specific biomarker for MCL. SOX11 is constantly overexpressed in virtually all aggressive MCLs, and at lower levels in a subgroup of Burkitt lymphoma and acute lymphoblastic leukemia but not in other lymphoid neoplasms. SOX11 was found exclusively overexpressed in conventional MCL and totally absent in normal lymphoid cells or in MCL patients with indolent clinical course and prolon

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29

Leslie, Kevin A. "Evaluation and Adaptation of Live-Cell Interferometry for Applications in Basic, Translational, and Clinical Research." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5562.

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Cell mass is an important indicator of cell health and status. A diverse set of techniques have been developed to precisely measure the masses of single cells, with varying degrees of technical complexity and throughput. Here, the development of a non-invasive, label-free optical technique, termed Live-Cell Interferometry (LCI), is described. Several applications are presented, including an evaluation of LCI’s utility for assessing drug response heterogeneity in patient-derived melanoma lines and the measurement of CD3+ T cell kinetics during hematopoietic stem cell transplantation. The charac

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30

Van, Zijl Karen. "The utilization of gestalt play therapy concepts and techniques with the pediatric hematology/oncology patient." Diss., 2008. http://hdl.handle.net/10500/3000.

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In this study the researcher explored and described the utilization of Gestalt play therapy concepts and techniques in order to strengthen the sense of self of the pediatric hematology/oncology patient. Literature studies were compiled to examine the concepts of the pediatric hematology/oncology patient, sense of self and Gestalt play therapy. These literature studies provided the theoretical frame in which the study was executed. During the empirical study qualitative data was gathered by means of unstructured interviews within an instrumental case study. Eight therapy sessions were c

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31

Βλάχα, Βασιλική. "Η δραστηριότητα της β-γλυκουρονίδασης στο εγκεφαλονωτιαίο υγρό παιδιών με οξεία λεμφοβλαστική λευχαιμία". Thesis, 2004. http://nemertes.lis.upatras.gr/jspui/handle/10889/3310.

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Lopes, Carina Inês Fontinha. "Relatório de Estágio - Mestrado em Análises Clínicas." Master's thesis, 2020. http://hdl.handle.net/10316/93030.

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Relatório de Estágio do Mestrado em Análises Clínicas apresentado à Faculdade de Farmácia<br>This report describes the activities developed during the curricular internship at the Instituto Português de Oncologia de Coimbra Francisco Gentil whithin the scope of the Master’s Degree of Clinical Analysis of the Faculty of Pharmacy in University of Coimbra, for 6 mouth period. Clinical analysis are one of the most important complementary means for the diagnosis and monitoring of oncological diseases. Cancer, by itself, is a complex process in all aspects. It arises from the abnormal proliferation

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Marques, Joana Daniela Sérgio. "Relatório de Estágio - Mestrado em Análises Clínicas." Master's thesis, 2020. http://hdl.handle.net/10316/93050.

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Relatório de Estágio do Mestrado em Análises Clínicas apresentado à Faculdade de Farmácia<br>Resumo O presente relatório de estágio foi elaborado no âmbito do Mestrado em Análises Clínicas. Oestágio teve lugar no laboratório do Serviço de Patologia Clínica do Instituto Português deOncologia de Coimbra Francisco Gentil com uma duração de 6 meses.O cancro é uma das principais causas de morte no mundo pelo que tem sido alvo de grandeinvestigação científica, que possibilitou enormes avanços nos métodos de diagnóstico e nasterapias. O laboratório clínico, em colaboração com o médico, tem um papel

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Sebastião, Beatriz Ribeiro. "Relatório de estágio." Master's thesis, 2019. http://hdl.handle.net/10316/88189.

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Relatório de Estágio do Mestrado em Análises Clínicas apresentado à Faculdade de Farmácia<br>O presente relatório é referente ao estágio curricular realizado no âmbito do Mestrado em Análises Clínicas, que teve início em dezembro de 2018 e terminou em maio de 2019, desenvolvido no IPO de Coimbra e teve como objetivo a consolidação e desenvolvimento dos conhecimentos adquiridos assim como a sua associação a um ambiente profissional. Este relatório consiste num relato das atividades desenvolvidas nos vários setores do Laboratório de Patologia Clínica e da sua importância no contexto de um hospit

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Χατίρη, Ειρήνη. "Δραστικότητα λυοσωματικών ενζύμων στα λευκά αιμοσφαίρια και το πλάσμα αίματος ασθενών με μεσογειακή αναιμία". Thesis, 2003. http://nemertes.lis.upatras.gr/jspui/handle/10889/3296.

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36

Angermeier, Stefan [Verfasser]. "Messung von L-Asparaginase-Antikörper-Titern von pädiatrischen Patienten mit akuter lymphatischer Leukämie der Nordic Society of Pediatric Hematology and Oncology unter Einsatz eines epitopspezifischen ELISA / vorgelegt von Stefan Angermeier." 2008. http://d-nb.info/995918937/34.

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Carpenter, Zachary Wayne. "Structure Function Analysis of Drug Resistance Driver Mutations in Acute Lymphoblastic Leukemia." Thesis, 2017. https://doi.org/10.7916/D8S46XQD.

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Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic tumor and is the most common malignancy in children (Horton and Steuber 2014). This disease is characterized by the infiltration of bone marrow by malignant immature lymphoid progenitor cells and is invariably fatal without treatment. Although multi-agent combination chemotherapy is curative in a significant fraction of ALL patients, treatment currently fails in approximately 20% of children and up to 50% of adults with ALL, making relapse and drug resistance the most substantial challenge in the treatment of this disease(Fieldin

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38

Lamothe, Martin. "Effets de la pleine conscience sur l’empathie, les compétences émotionnelles, le cortisol capillaire, et le stress psychologique des soignants en hémato-oncologie pédiatrique." Thèse, 2018. http://hdl.handle.net/1866/22684.

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