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Dissertations / Theses on the topic 'Hematopoiesis Regulation'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 January 2023

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1

Huang, Hsuan-Ting. "Epigenetic Regulation of Hematopoiesis in Zebrafish." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10175.

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The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of chromatin factors that establish the genetic code during developmental hematopoiesis, we conducted a large-scale reverse genetic screen targeting 425 chromatin factors in zebrafish and identified over 30 novel chromatin regulators that function at distinct steps of embryonic hematopoiesis. In vertebrates, developmental hematopoiesis occurs in two waves. During the first and p
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2

Ullrich, Sebastian 1984. "Alternative mechanisms of gene regulation during hematopoiesis." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665801.

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Gene regulation orchestrates the development of different cell types and organs from the same genetic blueprint. While the basic mode of gene regulation is driven by transcription factors, there are a variety of other mechanisms that determine the amount of RNA produced per genes. In this work we first investigate specifically intron retention as a mode of alternative splicing that alters the cellular transcriptomes. As a model, we use hematopoiesis. We compare intron retention in different stages of human and mouse B-cell development to granulocyte differentiation. We further explore expressi
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3

Durand, Ellen Marie. "Regulation of hematopoietic stem cell migration and function." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11550.

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Hematopoietic stem cell transplantation (HSCT) is an effective treatment for blood disorders and autoimmune diseases. Following HSCT, these cells must successfully migrate to the marrow niche and replenish the blood system of the recipient. This process requires both non-cell and cell-autonomous regulation of hematopoietic stem and progenitor cells (HSPCs). A transgenic reporter line in zebrafish allowed the investigation of factors that regulate HSPC migration and function. To directly observe cells in their endogenous microenvironment, confocal live imaging was used to track runx1:GFP+ HSP
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4

Martin, Richard. "Regulation of SCL expression and function in hematopoiesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85582.

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The development of the hematopoietic system occurs in two waves: a first wave of primitive erythropoiesis, which consists in the production of a single lineage, primitive erythrocytes, and a second wave of definitive hematopoiesis, which describes the generation of many specialized blood cell types from common hematopoietic stem cells. Whereas definitive hematopoiesis is fairly well understood, involves signals from the environment and the expression of lineage-specific transcription factors, the molecular mechanisms regulating primitive erythropoiesis remain to be defined. The aim of t
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5

Smith, Molly. "Alternative Splicing and Regulation of Innate Immune Mediators in Normal and Malignant Hematopoiesis." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563527303459942.

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6

Gronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.

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Bibliography: leaves 152-223. Experiments were designed to identify and purify human bone marrow stromal precursor cells by positive immunoselection, based on the cell surface expression of the VCAM-1 and STRO-1 antigens. The data presented demonstrates a hierarchy of bone cell development in vitro.
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7

Gaboury, Louis A. "Studies of the role of mesenchymal cells in the regulation of hemopoiesis." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28784.

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Hemopoiesis is thought to be regulated in part by specific, but as yet undefined, interactions between primitive hemopoietic cells and fixed, non-hemopoietic marrow elements collectively referred to as the stroma. Recently, a marrow culture system has been described that allows the maintenance of primitive human hemopoietic progenitor cells for many weeks in the absence of exogenously added hemopoietic growth factors. The formation of a heterogeneous adherent layer in which many stromal elements are found appears to be important to the maintenance of hemopoiesis in this system. As part of the
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8

Serbanovic-Canic, Jovana. "Using zebrafish to identify new regulators of haematopoiesis." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607950.

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9

Rothberg, Janet L. "Polycomb-like 2 (Mtf2/Pcl2) is Required for Epigenetic Regulation of Hematopoiesis." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35323.

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Polycomb proteins are epigenetic regulators that are critical in mediating gene repression at critical stages during development. Core and accessory proteins make up the Polycomb Repressive Complex 2 (PRC2), which is responsible for trimethylation of lysine 27 on histone 3 (H3K27me3), leading to maintenance of chromatin compaction and sustained gene repression. Classically, Polycomb accessory proteins are often thought of as having minor roles in fine-tuning the repressive action of PRC2. Their actions have often been attributed to chromatin recognition, targeting to specific loci and enhancin
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10

Jarratt, Andrew. "Locus-wide studies into the transcriptional regulation of Runx1 in developmental hematopoiesis." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572521.

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Developmental hematopoiesis sees the generation of the first blood cells and definitive blood during embryonic development. The founding cell of definitive hematopoiesis, the hematopoietic stem cell (HSC), gives rise to all adult blood :I: ]] 1:: t '.1 '4 !..:. : 1 1 '.! . lineages throughout the the life span or an orgamism. It IS expected that future ex-vivo manipulation ofHSCs for therapeutic uses will benefit from a thorough understanding of the mechanisms, both cellular and genetic, that give rise to HSCs. One of the most critical regulators of HSC emergence in the embryo is the transcrip
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11

Junkunlo, Kingkamon. "Regulation of hematopoiesis in the freshwater crayfish, Pacifastacus leniusculus : role of transglutaminase." Doctoral thesis, Uppsala universitet, Jämförande fysiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327921.

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The freshwater crayfish, Pacifastacus leniusculus, has been used as a model for studying hematopoiesis or blood cell production or hematopoiesis and immunity. The work of this thesis aims to investigate the impact of factors such as ROS signaling, Ast1, and the PVF/PVR signaling pathway in controlling stem cell behavior during hematopoiesis and specifically the role of the crosslinking enzyme transglutaminase (TGase) in regulation of hematopoiesis. The role of ROS in crayfish hematopoiesis was characterized by using the antioxidant named NAC to inhibit ROS production. Low ROS level resulted in
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12

Chiou, Chuang-Jiun. "Expression of Granulocyte-Macrophage Colony-Stimulating Factor Gene in Insect Cells by a Baculovirus Vector." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798471/.

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The focus of this research is to describe the production and characterization of the human granulocyte-macrophage colony-stimulating factor (hGM-CSF) in insect cells, using Autographa californica buclear polyhedrosis virus (AcNPV) as an expression vector. All three forms of biological activity of hGM-CSF. Following N-glycanase treatment, the two glycosylated hGM-CSF proteins (15.5 and 16.5 KDa) which bound to Concanavalin A affinity column ran as a 14.5-15.5 KDa band on SDS-PAGE. Western blot analysis of expression in Sf9 cells treated with tunicamycin revealed only the presence of the 14.5 KD
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13

Robinson, Simon N. "Proliferation regulation of haematopoietic stem cells in normal and leukaemic haematopoiesis." Thesis, University of St Andrews, 1992. http://hdl.handle.net/10023/14965.

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The cellular integrity of the blood is maintained by the cellular output of the haematopoietic stem cell population which produces the specialized precursors and differentiated cells which constitute the blood. The investigation of haematopoietic stem cell behaviour and regulation has been hampered by both the difficulty in their identification and the development of relevant assay systems. The purpose of this investigation was to study the behaviour and regulation of the haematopoietic stem cell population in normal and leukaemic haematopoiesis using an in vitro assay of a primitive haematopo
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14

Wang, Dennis Yi Qing. "Statistical modelling of gene regulation : applications to haematopoiesis." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607969.

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15

Maganti, Harinad. "Polycomb-like 2 (Mtf2/Pcl2) Mediated Epigenetic Regulation of Hematopoiesis and Refractory Leukemia." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37251.

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The Polycomb Repressive Complex 2 (PRC2) epigenetically regulates gene expression by methylating lysine 27 on histone 3 (H3K27me3). While the role of PRC2 core members during hematopoiesis has been elucidated, the role of PRC2 accessory protein, Mtf2, has not been well characterized outside of mouse embryonic stem cells. To investigate the role of Mtf2 in vivo, we created a gene-targeted knockout mouse model. Using this model, we discovered that Mtf2 was a critical regulator of hematopoiesis and its loss within the hematopoietic cells leads to loss of global H3K27me3 levels at the transcriptio
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16

Haylock, David Norman. "Ex vivo expansion of human haemopoietic progenitor cells." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phh4181.pdf.

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"December 2001." Includes bibliographical references (leaves 178-225) Focuses on the ex vivo growth of human haemopoietic progenitor cells with the objective of defining culture conditions for generating myeloid post-progenitor cells for therapy
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17

Dong, Wei-Feng. "Expression and regulation of rhombotin-2 (RBTN/LMO-2) in normal hematopoiesis and leukemogenesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ53807.pdf.

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18

Zannettino, Andrew Christopher William. "Molecular definition of stromal cell-stem cell interactions /." Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phz32.pdf.

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19

Ma, Chun-hang. "Gene regulation of zebrafish hematopoiesis during embryonic development with special references to survivins and jak2a." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41897249.

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20

Yates, Jeffrey Lynn. "THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM/PROGENITOR CELLS TO THE CYTOSTATIC AGENT HYDROXYUREA." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/420.

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Cellular proliferation is a key characteristic of hematopoietic stem and progenitor cells (HSC/HPCs) that allows for the production of all blood cell lineages during an individuals lifetime. While this feature of stem cells is strictly regulated during steadystate and stress hematopoiesis, it also contributes to the development of myeloproliferative disorders, such as chronic myelogenous leukemia, essential thrombocythemia, and polycythemia vera. It should come as no surprise then, that common treatments for these diseases often target the proliferative nature of the dysfunctional HSC/HPCs. Th
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21

Ma, Chun-hang, and 馬進恆. "Gene regulation of zebrafish hematopoiesis during embryonic development with special references to survivins and jak2a." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41897249.

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22

Varga, Andrea Erica. "Molecular characterisation, regulation and evolutionary analysis of uroplakin 1B : a tetraspanin family member /." Title page, errata, table of contents and summary only, 2003. http://hdl.handle.net/2440/37940.

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Uroplakin 1B (UPKIB) is an integral structural protein interacting with uroplakins 1A, 2 and 3 to form hexameric plaques along the bladder lumen in the asymmetric unit membrane of urothelial umbrella cells in humans and other mammals. UPKIB mRNA expression is deregulated in transitional cell carcinomas (TCCs), however the mechanisms of regulation of UPKIB have not been established. Using genome databases, a Xenopus UPKIB homologue was identified. Maximum Parsimony and BAMBE (Bayesian Analysis in Molecular Biology and Evolution) data support a close evolutionary relationship between mammalian a
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23

Gilmore, William Samuel. "A study of molecules involved in the regulation of the growth of haematopoietic cells and heart muscle cells in culture." Thesis, University of St Andrews, 1986. http://hdl.handle.net/10023/14970.

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The description of the molecular events responsible for the control of cell division and differentiation is, currently, one of the major goals of molecular and cellular biologists. Cell and tissue culture techniques have proved to be promising laboratory tools for the study of the regulators of cellular growth and differentiation. Most cells in culture require specific polypeptide growth factors which are supplied by the addition of a complex biological fluid such as serum or, in some instances, by the cells themselves. These growth factors usually act on their target cell via a membrane recep
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24

Deng, Ruixia, and 邓瑞霞. "Astragaloside IV promotes haematopoiesis and enhances cytokines release by mesenchymal stromal cells mediated immune regulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198839.

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Although tremendous efforts have been made to search for other novel growth factors in promoting marrow recovery after irradiation or chemotherapy, there have not been any efficient and safe agents discovered so far. Danggui Buxue Tang (當歸補血湯) as a traditional Chinese herbal decoction, is commonly used for replenishing blood loss in menstruating women, or enhancing erythropoiesis and immune responses in various settings. Our previous study confirmed that Danggui Buxue Tang promotes haematopoiesis and thrombopoiesis both in vitro & in vivo. Recent studies also showed that parenteral Astragalus
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25

An, Ningfei, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft, and Yubin Kang. "Pim1 kinase regulates c-Kit gene translation." BIOMED CENTRAL LTD, 2016. http://hdl.handle.net/10150/622957.

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Background: Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. Methods and results: We demonstrated that loss of Pim1 led to specific down-regulation of c-Kit expression in HSPCs of Pim1(-/-)mice and Pim1(-/-)2(-/-)3(-/-) triple knockout (TKO) mice, and resulted in attenu
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26

Chen, Aichun. "Regulation of lozenge transcription factor activity and blood cell development by MLF and its partner DnaJ-1." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30064/document.

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L'hématopoïèse est le processus de formation des cellules sanguines différenciées à partir de cellules souches hématopoïétiques. Ce processus est étroitement contrôlé par l'intégration de signaux de développementaux et homéostatiques pour assurer une production équilibrée des différents types de cellules sanguines. Au niveau moléculaire, la régulation de ce processus est médiée par un certain nombre de facteurs de transcription, en particulier par les membres de la famille RUNX. Ainsi, des mutations affectant les membres de cette famille peuvent entrainer une déréglementation du programme de d
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27

Sha, Xiaojin. "Translation initiation factor 4E binding protein 1,2 (4E-BP1,2) in hematopoiesis and stress erythropoiesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15797.

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Das Eukaryotische-Initiations faktor-4E Bindungsprotein (4E-BP) ist ein Inhibitor der Translationsinitiation. Nicht-phosphoryliertes 4E-BP bindet an den eukaryotischen Initiationsfaktor 4E (eIF4E). Diese Bindung blockiert die Rekrutierung des Initiationskomplexes eIF4F an die Cap-Struktur des 5´Endes von eukaryotischen zellulären mRNAs, was die Initiation der Translation verhindert. Phosphorylierung von 4E-BP durch die mTOR Kinase führt zur Dissoziation des 4E-BP/eIF4E Komplexes und erhöht die Verfügbarkeit von eIF4E, dies wird mit Zellproliferation assoziiert. Die Aktivität von eIF4E wird nic
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28

Hultquist, Anne. "Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5070-9/.

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29

Hu, Nan. "Erk1/2 Signaling Pathway and Transcriptional Repressor Gfi1 in the Regulation of Neutrophil versus Monocyte Development in Response to G-CSF and M-CSF." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1440089200.

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30

Renström, Jonas Verfasser], Jochen [Akademischer Betreuer] Graw, Robert A. J. [Akademischer Betreuer] Oostendorp, and Angelika [Akademischer Betreuer] [Schnieke. "The regulation of hematopoiesis by stromal cells / Lars Jonas Mikael Renström. Gutachter: Jochen Graw ; Robert A. J. Oostendorp ; Angelika Schnieke. Betreuer: Robert A. J. Oostendorp." München : Universitätsbibliothek der TU München, 2010. http://d-nb.info/1013436938/34.

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31

Lung, Tina Kathy. "Analysis of Mouse EKLF/KLF2 E9.5 Double Knockout: Yolk Sac Morphology and Embryonic Erythroid Maturation." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1821.

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32

Apostolov, Apostol. "Studying the posttranslational modifications of transcription factor Ikaros and their role in its function." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00923158.

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The main topic of my PhD studies was to investigate the role of sumoylation in the function of Ikaros transcription factor, that regulates the lymphocyte differentiation and function. Sumoylation is a posttranslational modification that can change the properties and regulate the function of a given protein. Up to now, one study addressed the question of how sumoylationmodulates Ikaros function. It shows that Ikaros is sumoylated in total primary thymocytes, and that this dynamic event modulates Ikaros' repressive function. It also describes two consensus sumoylation sites on Ikaros (K58 and K2
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33

Torres, Núñez Eva. "Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/133023.

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The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular matrix helps cells to bind together and regulates several cellular functions such as adhesion, migration, proliferation and differentiation. It is composed of growth factors, proteoglycans, structural proteins and matricellular proteins. Osteonectin, also named Sparc (Secreted Protein Acidic and Rich in Cysteine) or BM-40 (Membrane Protein-40), is a multifunctional glycoprotein that belon
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34

Perrod, Chiara. "Epigenetic PU.1 silencing in myeloid leukemia by mimicrying a T cell specific chromatin loop." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16863.

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Veränderungen in der lokalen Chromatinstruktur beeinflussen die dynamische Regulation von Genen, welche für die Differenzierung notwendig sind. PU.1 ist ein Master-Transkriptionsfaktor in der Hämatopoese und wird streng reguliert, um ein zelllinienspezifisches Expressionsmuster zu erzielen. Hohe Konzentrationen von PU.1 sind für myeloische Differenzierung erforderlich. In B-Zellen wird PU.1 mittelstark exprimiert und muss aktiv runterreguliert werden, um eine Ausdifferenzierung der multipotenten Vorläuferzellen zu T-Zellen zu ermöglichen. Derzeit ist wenig über die Regulierung von PU.1 in T-
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35

Corbel, Stéphane. "Mise en évidence d'un transport bi-directionnel d'histamine dans les progéniteurs hématopoïétiques murins." Paris 5, 1997. http://www.theses.fr/1997PA055001.

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L'histamine, un médiateur forme après décarboxylation de l'histidine par une enzyme l'histidine décarboxylase (HDC), est produite par différents types cellulaires du système immunitaire ou nerveux. Sa qualité d'agent immunomodulateur et de neurotransmetteur est clairement démontrée. Son rôle dans les phénomènes de prolifération et différenciation cellulaires est également suggéré par de nombreux faits expérimentaux. L'histamine pourrait aussi être impliquée dans l'hématopoïèse, et quelques arguments sont en faveur de cette possibilité. Ainsi, dans le laboratoire, nous avons montré une producti
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36

Oakley, Erin J. "GENETIC REGULATION OF HEMATOPOIETIC STEM CELL AGING." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/659.

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It is well documented that both quantitative and qualitative changes in the murine hematopoietic stem cell (HSC) population occur with age. In mice, the effect of aging on stem cells is highly strain-specific, thus suggesting genetic regulation plays a role in HSC aging. In C57BL/6 (B6) mice, the HSC population steadily increases with age, whereas in DBA/2 (D2) mice, this population declines. Our lab has previously mapped a quantitative trait locus (QTL) to murine chromosome 2 that is associated with the variation in frequency of HSCs between aged B6 and D2 mice. In these dissertation studies,
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Nottingham, Wade. "Transcriptional regulation of Runx1 in the developing haematopoietic system." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670091.

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Hastreiter, Araceli Aparecida. "Avaliação de aspectos regulatórios da hematopoese em desnutrição proteico-energética experimental: papel das células endoteliais derivadas das células tronco mesenquimais medulares." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-22102014-155543/.

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A desnutrição proteico-energética (DPE) provoca anemia e leucopenia decorrente da redução de precursores hematopoéticos e comprometimento da produção de mediadores indutores da hematopoese, bem como alterações estruturais e ultra-estruturais na matriz extracelular medular. A hematopoese ocorre em nichos medulares distintos - endosteal e perivascular - que modulam os processos de diferenciação, proliferação e auto-renovação da célula tronco hematopoética (CTH). As células tronco mesenquimais (CTM) tem um papel importante na formação destes nichos, através da sua diferenciação nos diversos tipos
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McKim, Daniel Boyce. "Neuroimmune and Hematopoietic Regulation of Stress-Induced Anxiety." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492079844476452.

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40

Tshuikina, Wiklander Marina. "Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9206.

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Kriz, Vitezslav. "The Role of the SHB Adapter Protein in Cell Differentiation and Development." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6850.

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42

Ghadie, Mohamed A. "Analysis and Reconstruction of the Hematopoietic Stem Cell Differentiation Tree: A Linear Programming Approach for Gene Selection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32048.

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Stem cells differentiate through an organized hierarchy of intermediate cell types to terminally differentiated cell types. This process is largely guided by master transcriptional regulators, but it also depends on the expression of many other types of genes. The discrete cell types in the differentiation hierarchy are often identified based on the expression or non-expression of certain marker genes. Historically, these have often been various cell-surface proteins, which are fairly easy to assay biochemically but are not necessarily causative of the cell type, in the sense of being master t
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43

Xu, Dawei. "Telomerase activity and its regulation in malignant hematopoietic cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3815-6/.

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44

LIANG, YING. "GENETIC REGULATION OF HEMATOPOIETIC STEM CELL NUMBERS IN MICE." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/418.

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Hematopoietic stem cells (HSCs) transplantations are widely used for the treatment of hematological and non-hematological disorders in clinic. Successful transplantation requires sufficient number and efficient homing of HSCs. Many studies have focused on developing an effective strategy to expand functional HSC population. Some regulatory molecules have been recently shown great promise for controlling the amplification of HSCs. In these dissertation studies, I first aim to identify gene(s) and their allelic variants contributing to strain-specific difference in HSC numbers between C57BL/6 (B
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45

Copley, Michael Rebin. "Regulation of developmental changes in hematopoietic stem cell self-renewal." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44819.

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Mouse hematopoietic stem cells (HSCs) undergo a post-natal transition in several properties, including a marked reduction in their self-renewal activity. To investigate the molecular basis of this difference, we devised a single strategy to isolate fetal and adult HSCs at similarly high frequencies. This strategy, involving fluorescence-activated cell sorting of cells with a CD45⁺EPCR⁺CD48-CD150⁺ (ESLAM) phenotype, allows isolation of HSCs at a frequency of ~1 in 2 from all developmental time points tested (mouse embryonic day (E) 14.5 to adult). Comparison of differentially expressed genes in
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46

Van, der Wath Richard Carl. "Computational modelling of hematopoietic stem cell division and regulation dynamics." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608642.

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47

Sharma, Devyani. "Regulation Of Hematopoietic Stem Cells By Lipid and Mitochondrial Metabolism." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563295190003946.

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48

Foltz, Ian Nevin. "Regulation of the stress-activated protein kinase pathways in hematopoietic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ38887.pdf.

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49

Lee-Sayer, Sally. "Hyaluronan binding and CD44 in regulating hematopoiesis and CD8 T cell response." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61999.

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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.<br>Science, Faculty of<br>Microbiology and Immunology, Department of<br>Graduate
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50

Liu, Yi. "LATEXIN’S ROLE IN REGULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/11.

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Previous studies in our lab identified a novel gene, latexin (Lxn), that regulates murine hematopoietic stem cells through balancing apoptosis, self-renewal and proliferation. In these dissertation studies, I performed a series of experiments to examine the function of Lxn using a Lxn conventional knockout mouse, and characterize Lxn’s role in the presence of hematopoietic stresses such as ionizing radiation, cytokines induced-mobilization, and hematopoietic malignancy. The first series of experiments was designed to determine the role of Lxn in hematopoiesis under homeostatic conditions. I fo
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