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Journal articles on the topic 'Hematopoietic stem and progenitor cell'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Camargo, Fernando D. "In vivo Stem Cell Clonal Dynamics." Blood 126, no. 23 (2015): SCI—40—SCI—40. http://dx.doi.org/10.1182/blood.v126.23.sci-40.sci-40.

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Abstract Tremendous progress has been achieved in the characterization of the hematopoietic system over the past two decades. Historically, the main experimental approach used to elucidate and define these cellular relationships in the bone marrow (BM) has been the transplantation assay. For this reason, most of our knowledge about the in vivo properties of hematopoietic stem cells (HSCs) and progenitor cells has been derived from studies in the transplant context. Because of the lack of tractable systems, the mechanistic nature of non-transplant hematopoiesis has remained largely unexplored.

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2

Kristensen, Helene Bjoerg, Thomas Levin Andersen, Andrea Patriarca, et al. "Human hematopoietic microenvironments." PLOS ONE 16, no. 4 (2021): e0250081. http://dx.doi.org/10.1371/journal.pone.0250081.

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Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on the murine progenitor microenvironment and even less so on these microenvironments in humans. Characterization of these microenvironments is decisive for understanding hematopoiesis and finding new treatment modalities against bone marrow malignancies in the clinic. However, it is equally challenging, because hematopoietic stem cells are difficult

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3

Cheng, J., S. Baumhueter, G. Cacalano, et al. "Hematopoietic defects in mice lacking the sialomucin CD34." Blood 87, no. 2 (1996): 479–90. http://dx.doi.org/10.1182/blood.v87.2.479.bloodjournal872479.

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Although the pluripotent hematopoietic stem cell can only be definitively identified by its ability to reconstitute the various mature blood lineages, a diversity of cell surface antigens have also been specifically recognized on this subset of hematopoietic progenitors. One such stem cell-associated antigen is the sialomucin CD34, a highly O-glycosylated cell surface glycoprotein that has also been shown to be expressed on all vascular endothelial cells throughout murine embryogenesis as well as in the adult. The functional significance of CD34 expression on hematopoietic progenitor cells and

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4

Li, June, Daniel P. Sejas, and Qishen Pang. "Nucleophosmin Regulates Differentiation, Cell Cycle Progression, and Stress Response in Hematopoietic Progenitor Cells." Blood 106, no. 11 (2005): 312. http://dx.doi.org/10.1182/blood.v106.11.312.312.

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Abstract Nucleophosmin (NPM) is a multifunctional protein frequently overexpressed in actively proliferating cells including tumor and hematopoietic stem cells. Strong evidence indicates that NPM is involved in hematopoiesis and leukemic development. Here we report that NPM enhances the proliferative potential of hematopoietic stem/progenitor cells and increases cell survival upon stress challenge. Specifically, lin-Sca1+c-kit+ bone marrow cells transduced with retroviral vector expressing NPM exhibited higher proliferative rates in both short-term liquid culture and clonogenic progenitor cell

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5

Kuramoto, Ken, Dean A. Follmann, Peiman Hematti, et al. "Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates." Blood 103, no. 11 (2004): 4070–77. http://dx.doi.org/10.1182/blood-2003-08-2934.

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Abstract Hematopoietic cytokines such as filgrastim are used extensively to stimulate granulocyte production or to mobilize hematopoietic progenitors into the circulation; however, their effect on more primitive hematopoietic progenitor and stem cells in vivo is unknown, particularly in large animals or humans. In particular, there is concern that chronic therapy with cytokines could result in stem cell exhaustion or clonal dominance; however, direct assessment of the dynamics of individual stem and progenitor cell clones in vivo has not been previously reported. A number of models can be prop

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6

Chen, Yuhong, Mei Yu, Xuezhi Dai, et al. "Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells." Journal of Experimental Medicine 208, no. 5 (2011): 923–35. http://dx.doi.org/10.1084/jem.20101192.

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Mice and rats lacking the guanosine nucleotide-binding protein Gimap5 exhibit peripheral T cell lymphopenia, and Gimap5 can bind to Bcl-2. We show that Gimap5-deficient mice showed progressive multilineage failure of bone marrow and hematopoiesis. Compared with wild-type counterparts, Gimap5-deficient mice contained more hematopoietic stem cells (HSCs) but fewer lineage-committed hematopoietic progenitors. The reduction of progenitors and differentiated cells in Gimap5-deficient mice resulted in a loss of HSC quiescence. Gimap5-deficient HSCs and progenitors underwent more apoptosis and exhibi

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7

Velu, Chinavenmeni S., Michael Berk, Haiming Xu, et al. "The Ski oncoprotein regulates Hematopoietic Stem Cell Fitness and Functions as a Corepressor for Gfi1." Blood 112, no. 11 (2008): 1403. http://dx.doi.org/10.1182/blood.v112.11.1403.1403.

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Abstract Ski is a corepressor protein originally identified as a retrovirally transduced oncoprotein. Genetic deletion of Ski has revealed essential roles in multiple developmental processes. Suggestion that Ski may play a role in hematopoiesis first came from expression of v-Ski and c-Kit, which induced the continuous in vitro growth of primary avian multipotent progenitors. However, the hematopoietic phenotype of Ski−/− mice has not been described. Here, we show that Ski loss of function results in loss of hematopoietic stem cell (HSC) fitness and abnormal regulation of myeloid progenitor nu

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8

Hétu-Arbour, Roxann, Mouna Tlili, Fabio Luiz Bandeira Ferreira, Belma Melda Abidin, Edward O. Kwarteng, and Krista M. Heinonen. "Cell-Intrinsic WNT4 Promotes Hematopoietic Stem and Progenitor Cell Self-Renewal." Stem Cells 39, no. 9 (2021): 1207–20. http://dx.doi.org/10.1002/stem.3385.

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Abstract Although intracellular Wnt signaling pathways need to be tightly regulated to promote hematopoietic stem cell self-renewal, the source and identity of important Wnt ligands in the bone marrow is still largely unknown. The noncanonical ligand Wnt4 is expressed in the bone marrow as well as in the stroma, and its overexpression in fetal liver cells facilitates thymic recovery; however, its impact on adult hematopoietic stem cell function remains unclear. Here, we report that the deletion of Wnt4 from hematopoietic cells in mice (Wnt4Δ/Δ) resulted in decreased lymphopoiesis at steady sta

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9

Esmaeli-Azad, Babak, Anand S. Srivastava, Cybele Frederico, Geraldo Martinez, Satoshi Yasukawa, and Ewa Carrier. "Artificial Hematopoietic Stem Cell Niche Sustains Growth and Differentiation of Human ES-Derived Early Hematopoietic Progenitors." Blood 110, no. 11 (2007): 1415. http://dx.doi.org/10.1182/blood.v110.11.1415.1415.

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Abstract Using a novel Microplate Biomaterial Microarray (MBM™) technology, we have created an artificial hematopoietic stem cell niche that can sustain growth and differentiation of human embryonic stem cells-derived (hES) early hematopoietic progenitors. This hydrogel based ex-vivo niche allows uploading of human embryonal stem cells, human mesenchymal stem cells (MSC), genes (bcl-2 preventing apoptosis and HoxB4 enhancing hematopoiesis) and extracellular matrices to support growth and differentiation of human ES cells. These experiments were done using NIH-approved hES cell lines H1 and H9.

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Lin, Fan-ching, Megan Karwan, Bahara Saleh та ін. "IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation". Blood 124, № 25 (2014): 3699–708. http://dx.doi.org/10.1182/blood-2014-01-549527.

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Key Points IFN-γ alone leads to aplastic anemia by disrupting the generation of common myeloid progenitors and lineage differentiation. The inhibitory effect of IFN-γ on hematopoiesis is intrinsic to hematopoietic stem/progenitor cells.

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11

Upadhaya, Samik, Catherine M. Sawai, Efthymia Papalexi, et al. "Kinetics of adult hematopoietic stem cell differentiation in vivo." Journal of Experimental Medicine 215, no. 11 (2018): 2815–32. http://dx.doi.org/10.1084/jem.20180136.

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Adult hematopoiesis has been studied in terms of progenitor differentiation potentials, whereas its kinetics in vivo is poorly understood. We combined inducible lineage tracing of endogenous adult hematopoietic stem cells (HSCs) with flow cytometry and single-cell RNA sequencing to characterize early steps of hematopoietic differentiation in the steady-state. Labeled cells, comprising primarily long-term HSCs and some short-term HSCs, produced megakaryocytic lineage progeny within 1 wk in a process that required only two to three cell divisions. Erythroid and myeloid progeny emerged simultaneo

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12

Pereira, Joao P., Vivian Lim, Ana Gomes, et al. "Hematopoietic stem cell niches control multipotent progenitor differentiation." Journal of Immunology 196, no. 1_Supplement (2016): 122.1. http://dx.doi.org/10.4049/jimmunol.196.supp.122.1.

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Abstract Hematopoietic stem cells (HSC) self-renew in bone marrow niches formed by CXCL12+ mesenchymal progenitor and endothelial cells. Here, we show that hematopoietic multipotent progenitors (MPPs) encounter lineage-instructive differentiation signals in HSC niches. Conditional deletion of CXCR4 in MPPs profoundly reduced differentiation into common lymphoid progenitors (CLPs), which significantly decreased lymphopoiesis. CXCR4 was required for CLP positioning near IL-7+ cells and, consequently, for optimal IL-7R signaling. IL-7+ cells form a large subset of CXCL12-abundant reticular mesenc

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13

McRae, Helen M., Alexandra L. Garnham, Yifang Hu, et al. "PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia." Blood 133, no. 16 (2019): 1729–41. http://dx.doi.org/10.1182/blood-2018-07-860726.

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Abstract Somatically acquired mutations in PHF6 (plant homeodomain finger 6) frequently occur in hematopoietic malignancies and often coincide with ectopic expression of TLX3. However, there is no functional evidence to demonstrate whether these mutations contribute to tumorigenesis. Similarly, the role of PHF6 in hematopoiesis is unknown. We report here that Phf6 deletion in mice resulted in a reduced number of hematopoietic stem cells (HSCs), an increased number of hematopoietic progenitor cells, and an increased proportion of cycling stem and progenitor cells. Loss of PHF6 caused increased

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14

Ribatti, Domenico, and Antonio d’Amati. "Hematopoiesis and Mast Cell Development." International Journal of Molecular Sciences 24, no. 13 (2023): 10679. http://dx.doi.org/10.3390/ijms241310679.

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Hematopoietic stem cells (HSCs) are defined based on their capacity to replenish themselves (self-renewal) and give rise to all mature hematopoietic cell types (multi-lineage differentiation) over their lifetime. HSCs are mainly distributed in the bone marrow during adult life, harboring HSC populations and a hierarchy of different kinds of cells contributing to the “niche” that supports HSC regulation, myelopoiesis, and lymphopoiesis. In addition, HSC-like progenitors, innate immune cell precursors such as macrophages, mast cells, natural killer cells, innate lymphoid cells, and megakaryocyte

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15

Mitjavila-Garcia, Maria Teresa, Michel Cailleret, Isabelle Godin, et al. "Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells." Development 129, no. 8 (2002): 2003–13. http://dx.doi.org/10.1242/dev.129.8.2003.

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In this study, we have characterized the early steps of hematopoiesis during embryonic stem cell differentiation. The immunophenotype of hematopoietic progenitor cells derived from murine embryonic stem cells was determined using a panel of monoclonal antibodies specific for hematopoietic differentiation antigens. Surprisingly, the CD41 antigen (αIIb integrin, platelet GPIIb), essentially considered to be restricted to megakaryocytes, was found on a large proportion of cells within embryoid bodies although very few megakaryocytes were detected. In clonogenic assays, more than 80% of all progen

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16

Li, Xiaxin, P. Artur Plett, Yanzhu Yang, et al. "Fanconi anemia type C–deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control." Blood 102, no. 6 (2003): 2081–84. http://dx.doi.org/10.1182/blood-2003-02-0536.

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Abstract The pathogenesis of bone marrow failure in Fanconi anemia is poorly understood. Suggested mechanisms include enhanced apoptosis secondary to DNA damage and altered inhibitory cytokine signaling. Recent data determined that disrupted cell cycle control of hematopoietic stem and/or progenitor cells disrupts normal hematopoiesis with increased hematopoietic stem cell cycling resulting in diminished function and increased sensitivity to cell cycle–specific apoptotic stimuli. Here, we used Fanconi anemia complementation type C–deficient (Fancc–/–) mice to demonstrate that Fancc–/– phenotyp

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17

Ulloa, Bianca A., Samima S. Habbsa, Kathryn S. Potts, et al. "Definitive Hematopoietic Stem Cells Minimally Contribute to Embryonic Hematopoiesis." Blood 138, Supplement 1 (2021): 3268. http://dx.doi.org/10.1182/blood-2021-147998.

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Abstract Definitive hematopoietic stem cells (HSCs) emerge in the embryo and sustain major adult hematopoietic lineages. Although their functional potential is detected by transplant, nascent HSC contribution during development is both unknown and difficult to address due to the overlapping emergence of HSC-independent progenitors-cells that lack the multipotency and/or longevity of HSCs but express many of the same markers. Using sorted hematopoietic stem and progenitor cells from zebrafish embryos, we performed single cell RNA sequencing to decipher HSC and HSC-independent progenitor heterog

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18

Koeniger, Tobias, Luisa Bell, Anika Mifka, et al. "Bone marrow-derived myeloid progenitors in the leptomeninges of adult mice." Stem Cells 39, no. 2 (2020): 227–39. http://dx.doi.org/10.1002/stem.3311.

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Abstract Although the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with hematopoietic progenitor properties have even been reported in the adult brain under steady-state conditions, but their nature and localization remain insufficiently defined. Here, we describe a heterogeneous population of myeloid progenitors in the leptomeninges of adult C57BL/6 mice. This cell pool included common myeloid, granulocyte/macrophage, and megakaryocyte/erythrocyte progenitors. Accordingly, i

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19

Jing, Lili, Owen J. Tamplin, Michael J. Chen, et al. "Adenosine signaling promotes hematopoietic stem and progenitor cell emergence." Journal of Experimental Medicine 212, no. 5 (2015): 649–63. http://dx.doi.org/10.1084/jem.20141528.

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Hematopoietic stem cells (HSCs) emerge from aortic endothelium via the endothelial-to-hematopoietic transition (EHT). The molecular mechanisms that initiate and regulate EHT remain poorly understood. Here, we show that adenosine signaling regulates hematopoietic stem and progenitor cell (HSPC) development in zebrafish embryos. The adenosine receptor A2b is expressed in the vascular endothelium before HSPC emergence. Elevated adenosine levels increased runx1+/cmyb+ HSPCs in the dorsal aorta, whereas blocking the adenosine pathway decreased HSPCs. Knockdown of A2b adenosine receptor disrupted sc

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Kundu, Mondira, Amy Chen, Stacie Anderson, et al. "Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11." Blood 100, no. 7 (2002): 2449–56. http://dx.doi.org/10.1182/blood-2002-04-1064.

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Core-binding factor β (CBFβ) and CBFα2 form a heterodimeric transcription factor that plays an important role in hematopoiesis. The genes encoding either CBFβ or CBFα2 are involved in chromosomal rearrangements in more than 30% of cases of acute myeloid leukemia (AML), suggesting that CBFβ and CBFα2 play important roles in leukemogenesis. Inv(16)(p13;q22) is found in almost all cases of AML M4Eo and results in the fusion ofCBFB with MYH11, the gene encoding smooth muscle myosin heavy chain. Mouse embryos heterozygous for aCbfb-MYH11 knock-in gene lack definitive hematopoiesis, a phenotype shar

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21

Keller, U., MJ Aman, G. Derigs, C. Huber, and C. Peschel. "Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor." Blood 84, no. 7 (1994): 2189–96. http://dx.doi.org/10.1182/blood.v84.7.2189.2189.

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Abstract Interleukin-4 (IL-4) has distinct hematopoietic activities, primarily as a costimulant with other cytokines to enhance colony formation of hematopoietic progenitors. We investigated the influence of IL-4 on stromal cell-supported long-term cultures (LTCs) of normal human bone marrow. Addition of IL-4 to LTCs of unseparated bone marrow or highly enriched CD34+ cells resulted in a significant increase of myeloid progenitors in the nonadherent, as well as in the stromal cell-adherent cell populations. In contrast, the total cell number was not influenced by IL-4, suggesting a selective e

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Keller, U., MJ Aman, G. Derigs, C. Huber, and C. Peschel. "Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor." Blood 84, no. 7 (1994): 2189–96. http://dx.doi.org/10.1182/blood.v84.7.2189.bloodjournal8472189.

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Interleukin-4 (IL-4) has distinct hematopoietic activities, primarily as a costimulant with other cytokines to enhance colony formation of hematopoietic progenitors. We investigated the influence of IL-4 on stromal cell-supported long-term cultures (LTCs) of normal human bone marrow. Addition of IL-4 to LTCs of unseparated bone marrow or highly enriched CD34+ cells resulted in a significant increase of myeloid progenitors in the nonadherent, as well as in the stromal cell-adherent cell populations. In contrast, the total cell number was not influenced by IL-4, suggesting a selective effect on

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Paz, Helicia, Maureen R. Lynch, Clifford W. Bogue, and Judith C. Gasson. "The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis." Blood 116, no. 8 (2010): 1254–62. http://dx.doi.org/10.1182/blood-2009-11-254383.

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Abstract The development and emergence of the hematopoietic stem cell involves a series of tightly regulated molecular events that are not well characterized. The hematopoietically expressed homeobox (Hhex) gene, a member of the homeobox gene family, is an essential regulator of embryogenesis and hematopoietic progenitor development. To investigate the role of Hhex in hematopoiesis we adapted a murine embryonic stem (ES) cell coculture system, in which ES cells can differentiate into CD41+ and CD45+ hematopoietic progenitors in vitro. Our results show that in addition to delayed hemangioblast

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Carlo-Stella, C., and V. Rizzoli. "In Vitro Manipulation of Peripheral Blood Progenitor Cell Collections." International Journal of Artificial Organs 21, no. 6_suppl (1998): 1–10. http://dx.doi.org/10.1177/039139889802106s01.

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Mobilized peripheral blood progenitor cells (PBPC) are increasingly used to reconstitute hematopoiesis in patients undergoing high-dose chemoradiotherapy. PBPC collections comprise a heterogeneous population containing both committed progenitors and pluripotent stem cells and can be harvested (i) in steady state, (ii) after chemotherapeutic conditioning, (iii) growth factor priming, or (iv) both. The use of PBPC has opened new therapeutic perspectives mainly related to the availability of large amounts of mobilized hematopoietic stem and progenitor cells. Extensive manipulation of the grafts,

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van Dijken, PJ, J. Wimperis, JM Crawford, and JL Ferrara. "Effect of graft-versus-host disease on hematopoiesis after bone marrow transplantation in mice." Blood 78, no. 10 (1991): 2773–79. http://dx.doi.org/10.1182/blood.v78.10.2773.bloodjournal78102773.

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We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of hematopoietic progenitors in the BM, which remained decreased in all transplant recipients. Donor stem cells (colony-forming unit-spleen day 8) and stem cell self-renewal remained low in all mice for 5 months after transplant, but GVHD further damaged the stem cell compartment. Per

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Woolthuis, Carolien M., and Christopher Y. Park. "Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage." Blood 127, no. 10 (2016): 1242–48. http://dx.doi.org/10.1182/blood-2015-07-607945.

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Abstract The classical model of hematopoiesis has long held that hematopoietic stem cells (HSCs) sit at the apex of a developmental hierarchy in which HSCs undergo long-term self-renewal while giving rise to cells of all the blood lineages. In this model, self-renewing HSCs progressively lose the capacity for self-renewal as they transit into short-term self-renewing and multipotent progenitor states, with the first major lineage commitment occurring in multipotent progenitors, thus giving rise to progenitors that initiate the myeloid and lymphoid branches of hematopoiesis. Subsequently, withi

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Gordon, M. Y., and N. M. Blackett. "Reconstruction of the Hematopoietic System after Stem Cell Transplantation." Cell Transplantation 7, no. 4 (1998): 339–44. http://dx.doi.org/10.1177/096368979800700401.

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The practice of hematopoietic stem cell transplantation to rescue patients from the myeloablative effects of chemo- or radiotherapy, or to replace defective hematopoiesis, is based on the assumption that hematopoietic stem cells in the graft have sufficient proliferative potential to supply mature blood cells for the remainder of the recipient's lifespan. However, the mechanism(s) whereby this is achieved are not well understood. Here we address the reconstruction of the hematopoietic system by considering the effects of stem cell and progenitor cell renewal and differentiation. We conclude th

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Pinto do Ó, Perpétua, Karin Richter, and Leif Carlsson. "Hematopoietic progenitor/stem cells immortalized byLhx2 generate functional hematopoietic cells in vivo." Blood 99, no. 11 (2002): 3939–46. http://dx.doi.org/10.1182/blood.v99.11.3939.

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Hematopoietic stem cells (HSCs) are unique in their capacity to maintain blood formation following transplantation into immunocompromised hosts. Expansion of HSCs in vitro is therefore important for many clinical applications but has met with limited success because the mechanisms regulating the self-renewal process are poorly defined. We have previously shown that expression of the LIM-homeobox gene Lhx2 in hematopoietic progenitor cells derived from embryonic stem cells differentiated in vitro generates immortalized multipotent hematopoietic progenitor cell lines. However, HSCs of early embr

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Schuettpelz, Laura G., Priya K. Gopalan, Felipe O. Giuste, Molly P. Romine, Ronald van Os, and Daniel C. Link. "Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function." Blood 120, no. 15 (2012): 2981–89. http://dx.doi.org/10.1182/blood-2012-02-409839.

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AbstractIncreased expression of Kruppel-like factor 7 (KLF7) is an independent predictor of poor outcome in pediatric acute lymphoblastic leukemia. The contribution of KLF7 to hematopoiesis has not been previously described. Herein, we characterized the effect on murine hematopoiesis of the loss of KLF7 and enforced expression of KLF7. Long-term multilineage engraftment of Klf7−/− cells was comparable with control cells, and self-renewal, as assessed by serial transplantation, was not affected. Enforced expression of KLF7 results in a marked suppression of myeloid progenitor cell growth and a

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Chan, Charles, Ching-Cheng Chen, Daniel L. Kraft, et al. "Identification and Isolation of the Hematopoietic Stem Cell Niche Initiating Cell Population." Blood 112, no. 11 (2008): 3574. http://dx.doi.org/10.1182/blood.v112.11.3574.3574.

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Abstract Introduction: Identification and understanding of the cells and processes that can generate, sustain and influence the HSC niche and hematopoiesis are critical for the development of a more comprehensive knowledge of normal hematopoiesis, stem cell homing, trafficking, differentiation and hematopoietic pathology. Growth and renewal in many tissues are initiated by stem cells, supported by the microenvironment (niche) in which they reside. While recent work has begun to describe functional interactions between stem cells and their niches, little is known about the formation of stem cel

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Qian, Hong, Karl Tryggvason, Sten Eirik Jacobsen та Marja Ekblom. "Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins". Blood 107, № 9 (2006): 3503–10. http://dx.doi.org/10.1182/blood-2005-10-3932.

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The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse hematopoietic stem and progenitor cells. We have studied its role for homing of stem and progenitor cells to mouse hematopoietic tissues in vivo. A function-blocking anti–integrin α6 antibody significantly reduced progenitor cell homing to bone marrow (BM) of lethally irradiated mice, with a corresponding retention of progenitors in blood. Remarkably, the anti–integrin α6 antibody profoundly inhibited BM homing of long-term multilineage engrafting stem cells, studied by competitive repopulation assay and analys

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Köhler, Anja, Vince Schmithorst, Marie-Dominique Filippi, et al. "Intravital Imaging of Young and Aged Stem Cells in the Marrow of Long Bones: Visualizing Mammalian Stem Cell Behavior in Real-Time in Vivo." Blood 112, no. 11 (2008): 2418. http://dx.doi.org/10.1182/blood.v112.11.2418.2418.

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Abstract Hematopoiesis, the process in which blood cells are generated from hematopoietic stem and progenitor cells (HSPCs) is primarily confined to the bone cavities. The interactions of hematopoietic cells with stroma cells forming niches inside the bone cavities are central to hematopoiesis, as these regulate cell proliferation, self-renewal and differentiation. Hematopoietic cell/stroma interactions have thus been, in analogy to the immunological synapse, named stem/progenitor cell synapses. So far, visualization of the behavior of somatic stem and progenitor cells in an undisturbed in viv

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Manz, Markus G. "Microbial Impact on Hematologic Homeostasis." Blood 120, no. 21 (2012): SCI—40—SCI—40. http://dx.doi.org/10.1182/blood.v120.21.sci-40.sci-40.

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Abstract Abstract SCI-40 During systemic infection and inflammation, immune effector cells are in high demand and are rapidly consumed at sites of need. While adaptive immune cells have high proliferative potential, innate mature immune cells are mostly postmitotic and need to be replenished from bone marrow hematopoietic stem and progenitor cells. Indeed, severe clinical infection, particularly infections challenging the innate immune response, lead to an increase in hematopoietic differentiation and throughput in bone marrow, involving subsequent differentiation stages from hematopoietic ste

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Trowbridge, Jennifer J., Jonathan W. Snow, Jonghwan Kim, and Stuart H. Orkin. "DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells." Blood 114, no. 22 (2009): 392. http://dx.doi.org/10.1182/blood.v114.22.392.392.

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Abstract Abstract 392 DNA methylation is essential for development and plays crucial roles in a variety of biological processes. The DNA methyltransferase Dnmt1 serves to maintain parental cell methylation patterns on daughter DNA strands in mitotic cells, however, the precise role of Dnmt1 in regulation of quiescent adult stem cells is not known. To examine the role of Dnmt1 in adult hematopoietic stem cells (HSCs), we crossed Dnmt1fl/fl mice with Mx1-Cre transgenic mice, and by injection of poly(I)-poly(C) we selectively deleted Dnmt1 in the hematopoietic system (Dnmt1Δ/Δ). In Dnmt1Δ/Δ mice,

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Miyoshi, Hirotoshi, Chiaki Sato, Yuichiro Shimizu, and Misa Morita. "Expansion of mouse hematopoietic stem/progenitor cells in three-dimensional cocultures on growth-suppressed stromal cell layer." International Journal of Artificial Organs 42, no. 7 (2019): 374–79. http://dx.doi.org/10.1177/0391398819827596.

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With the aim of establishing an effective method to expand hematopoietic stem/progenitor cells for application in hematopoietic stem cell transplantation, we performed ex vivo expansion of hematopoietic stem/progenitor cells derived from mouse fetal liver cells in three-dimensional cocultures with stromal cells. In these cocultures, stromal cells were first cultured within three-dimensional scaffolds to form stromal layers and then fetal liver cells containing hematopoietic cells were seeded on these scaffolds to expand the hematopoietic cells over the 2 weeks of coculture in a serum-containin

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Meier‐Abt, F., S. Amon, L. Gillet, et al. "PF453 TRANSCRIPTOME‐PROTEOME CORRELATION IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS." HemaSphere 3, S1 (2019): 178. http://dx.doi.org/10.1002/j.2572-9241.2019.tb00052.x.

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Background:Hematopoietic stem cells (HSCs) can self‐renew and/or differentiate into various functionally divergent progenitor cell types, such as common myeloid progenitors (CMPs), megakaryocyte‐erythrocyte progenitors (MEPs) or granulocyte‐macrophage progenitors (GMPs). When the process of self‐renewal and differentiation is altered, e.g. upon genetic or epigenetic changes in HSCs, abnormal (pre)leukemic stem cell subpopulations may form, eventually resulting in the onset of hematopoietic malignancies. To gain insight into the physiology and patho‐physiology of self‐renewal and differentiatio

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Calés, Carmela, Leticia Pavón, Katarzyna Starowicz, et al. "Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis." Molecular and Cellular Biology 36, no. 6 (2015): 900–912. http://dx.doi.org/10.1128/mcb.00869-15.

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Polycomb chromatin modifiers regulate hematopoietic pluripotent stem and progenitor cell self-renewal and expansion. Polycomb complex redundancy and biochemical heterogeneity complicate the unraveling of the functional contributions of distinct components. We have studied the hematopoietic activity of RYBP, a direct interactor and proposed modulator of RING1A/RING1B-dependent histone H2A monoubiquitylation (H2AUb). Using a mouse model to conditionally inactivateRybpin adult hematopoiesis, we have found that RYBP deletion results in a reversion of B-1-to-B-2 B-cell progenitor ratios, i.e., of t

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Suh, Hyung Chan, Ming Ji, John Gooya, Michael Lee, Kimberly Klarmann, and Jonathan R. Keller. "Id1 Provides a Proper Hematopoietic Progenitor Niche Function." Blood 112, no. 11 (2008): 2427. http://dx.doi.org/10.1182/blood.v112.11.2427.2427.

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Abstract Development of hematopoietic stem cells (HSC) and their progeny is maintained by the interaction with cells in the microenvironment. In addition to hematopoietic cells, Id1 is expressed in stromal cells known to support hematopoiesis, and is involved in cell proliferation, differentiation and senescence. Therefore, to investigate the role of Id1 in hematopoiesis, we examined hematologic phenotypes of Id1−/− mice. In this study, we found increased neutrophils and macrophages, and decreased B cells and platelets in peripheral blood, and decreased BM cellularity. While the percentages of

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Ribeiro-Filho, Antonio Carlos, Débora Levy, Jorge Luis Maria Ruiz, Marluce da Cunha Mantovani, and Sérgio Paulo Bydlowski. "Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies." Cells 8, no. 12 (2019): 1628. http://dx.doi.org/10.3390/cells8121628.

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Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified in the bone marrow stem cell niche. Complex interactions between the bone marrow microenvironment and hematopoietic stem cells determine the balance between the proliferation, differentiation and homeostasis of the stem cell compartment. Changes in this tightly regulated network can provoke malignant transform

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van Os, Ronald, Albertina Ausema, Edo Vellenga, and Gerald de Haan. "Identification of Quantitative Trait Loci Regulating Steady State Hematopoiesis and Progenitor Mobilization in AKRB6F2 Mice." Blood 104, no. 11 (2004): 4165. http://dx.doi.org/10.1182/blood.v104.11.4165.4165.

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Abstract The hematopoietic system is a complex organized tissue with a hierarchical structure. Identification of organizational pathways within the hematopoietic system would be relevant for a better understanding of hematopoiesis in health and disease. We have analyzed numerous hematopoietic parameters in AKRB6F2 mice, a cross between AKR and C57Bl/6 mice that differ in various stem cell traits. Specifically, we have measured stem cell numbers, progenitor cell cycling, G-CSF induced stem cell mobilization, as well as neutrophil numbers in blood and bone marrow. We used these data to map quant

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Cheng, Yuanming, Hanzhi Luo, Franco Izzo, et al. "m6A Maintains Hematopoietic Stem and Progenitor Cell Identity." Blood 132, Supplement 1 (2018): 327. http://dx.doi.org/10.1182/blood-2018-99-117191.

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Abstract N-6-methyladenosine (m6A) is one of the most abundant posttranscriptional modifications in eukaryotic mRNAs and long noncoding RNAs. We previously found a critical role for m6A in promoting human myeloid leukemia (Vu et al. Nature Medicine 2017). Targeting the RNA methylation program in leukemias has been suggested as a potential novel therapeutic strategy. However, it is unknown whether the m6A modification controls normal adult hematopoiesis and hematopoietic stem cells (HSC) function. To investigate the role of m6A in adult hematopoiesis, we crossed with the Mettl3 conditional knoc

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Matula, Zsolt, Gyöngyi Kudlik, Veronika Urbán S., and Ferenc Uher. "Quo vadis, hematológia?" Orvosi Hetilap 157, no. 46 (2016): 1819–29. http://dx.doi.org/10.1556/650.2016.30580.

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For decades, developing hematopoietic cells have been strictly compartmentalized into a small population of multipotent self-renewing hematopoietic stem cells, multipotent hematopoietic progenitor cells that are undergoing commitment to myeloid or lymphoid fates, and unipotent precursor cells that mature towards peripheral blood and immune cells. Recent studies, however, have provided a battery of findings that cannot be explained by this “classical” hierarchical model for the architecture of hematopoiesis. It is emerging that heterogeneous hematopoietic stem cell populations in the bone marro

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Daria, Deidre, Marie-Dominique Filippi, Erik S. Knudsen, et al. "The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress." Blood 111, no. 4 (2008): 1894–902. http://dx.doi.org/10.1182/blood-2007-02-071746.

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The retinoblastoma tumor suppressor protein (RB) plays important roles in the control of the cell division cycle. It is estimated that RB is dysfunctional/inactivated in up to 40% of human leukemias. The consequences of loss of RB on hematopoietic stem and progenitor cell (HSPC) function in vivo are incompletely understood. Here, we report that mice genetically deficient in Rb in all hematopoietic cells (Vav-Cre Rb knockout [KO] animals) showed altered contribution of distinct hematopoietic cell lineages to peripheral blood, bone marrow, and spleen; significantly increased extramedullary hemat

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Perlingeiro, Rita C. R., Michael Kyba, and George Q. Daley. "Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential." Development 128, no. 22 (2001): 4597–604. http://dx.doi.org/10.1242/dev.128.22.4597.

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Embryonic stem (ES) cells differentiate into multiple hematopoietic lineages during embryoid body formation in vitro, but to date, an ES-derived hematopoietic stem cell has not been identified and subjected to clonal analysis in a manner comparable with hematopoietic stem cells from adult bone marrow. As the chronic myeloid leukemia-associated BCR/ABL oncogene endows the adult hematopoietic stem cell with clonal dominance without inhibiting pluripotent lymphoid and myeloid differentiation, we have used BCR/ABL as a tool to enable engraftment and clonal analysis. We show that embryoid body-deri

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Bhatia, Ravi, Khristine Van Heijzen, Ann Palmer, et al. "Longitudinal Assessment of Hematopoietic Abnormalities After Autologous Hematopoietic Cell Transplantation for Lymphoma." Journal of Clinical Oncology 23, no. 27 (2005): 6699–711. http://dx.doi.org/10.1200/jco.2005.10.330.

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Purpose Autologous hematopoietic cell transplantation (HCT) is being increasingly used as an effective treatment strategy for patients with relapsed or refractory Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL) but is associated with therapy-related myelodysplasia and acute myeloid leukemia (t-MDS/AML) as a major cause of nonrelapse mortality. The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood. Patients and Methods Using a prospective longitudinal study design, we evaluated the

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Peng, Hui, Ling Tang, Rui Sun, and Zhigang Tian. "The characteristics of liver hematopoietic progenitor cells (HEM5P.231)." Journal of Immunology 194, no. 1_Supplement (2015): 120.11. http://dx.doi.org/10.4049/jimmunol.194.supp.120.11.

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Abstract During fetal life, hematopoiesis majorly occurs in the liver. After birth, the site of hematopoiesis shifts from fetal liver to the bone marrow (BM). However, some recent studies have shown that the adult liver also contains stem cell population with potent hematopoietic-reconstitution potential. To investigate the properties of adult liver hematopoiesis, we compared the phenotype of liver lineage (Lin)-negative progenitor cells with that of BM counterparts. We found that Lin- cells in the adult liver are phenotypically distinct from BM Lin- cells. Moreover, transfer of fetal liver ce

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Salter, Alice B., Sarah K. Meadows, Garrett G. Muramoto, et al. "Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo." Blood 113, no. 9 (2009): 2104–7. http://dx.doi.org/10.1182/blood-2008-06-162941.

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Hematopoietic stem cells (HSCs) reside in association with bone marrow (BM) sinusoidal vessels in vivo, but the function of BM endothelial cells (ECs) in regulating hematopoiesis is unclear. We hypothesized that hematopoietic regeneration following injury is regulated by BM ECs. BALB/c mice were treated with total body irradiation (TBI) and then infused with C57Bl6-derived endothelial progenitor cells (EPCs) to augment endogenous BM EC activity. TBI caused pronounced disruption of the BM vasculature, BM hypocellularity, ablation of HSCs, and pancytopenia in control mice, whereas irradiated, EP

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van Dijken, PJ, J. Wimperis, JM Crawford, and JL Ferrara. "Effect of graft-versus-host disease on hematopoiesis after bone marrow transplantation in mice." Blood 78, no. 10 (1991): 2773–79. http://dx.doi.org/10.1182/blood.v78.10.2773.2773.

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Abstract We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of hematopoietic progenitors in the BM, which remained decreased in all transplant recipients. Donor stem cells (colony-forming unit-spleen day 8) and stem cell self-renewal remained low in all mice for 5 months after transplant, but GVHD further damaged the stem cell compart

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Hu, Xiaoxia, Hongmei Shen, Chen Tian, et al. "Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model." Blood 114, no. 18 (2009): 3783–92. http://dx.doi.org/10.1182/blood-2009-06-227843.

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Abstract The predominant outgrowth of malignant cells over their normal counterparts in a given tissue is a shared feature for all types of cancer. However, the impact of a cancer environment on normal tissue stem and progenitor cells has not been thoroughly investigated. We began to address this important issue by studying the kinetics and functions of hematopoietic stem and progenitor cells in mice with Notch1-induced leukemia. Although hematopoiesis was progressively suppressed during leukemia development, the leukemic environment imposed distinct effects on hematopoietic stem and progenito

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Li, Yan, Shi Chen, Jin Yuan, et al. "Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg−/− mice in vivo." Blood 113, no. 10 (2009): 2342–51. http://dx.doi.org/10.1182/blood-2008-07-168138.

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AbstractFanconi anemia (FA) is a heterogeneous genetic disorder characterized by bone marrow failure and complex congenital anomalies. Although mutations in FA genes result in a characteristic phenotype in the hematopoietic stem/progenitor cells (HSPCs), little is known about the consequences of a nonfunctional FA pathway in other stem/progenitor cell compartments. Given the intense functional interactions between HSPCs and the mesenchymalmicroenvironment, we investigated the FA pathway on the cellular functions of murine mesenchymal stem/progenitor cells (MSPCs) and their interactions with HS

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