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Dissertations / Theses on the topic 'Hematopoietic stem cell niche'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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1

Miladinović, Olivera. "Molecular profiling of the embryonic hematopoietic stem cell niche." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS025.pdf.

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Les cellules souches hématopoïétiques (CSH) constituent une population rare de cellules à la base du système hématopoïétique chez l’adulte. Au cours de l'ontogenèse, les premières CSH de type adulte sont générées de manière autonome dans la région Aorte-Gonades-Mésonephros (AGM) chez l’embryon de souris à la moitié de la gestation. Plus précisément, les CSH naissent à partir de cellules endothéliales aortiques au cours d’une transition cellule endothéliale-cellule hématopoïétique. Le microenvironnement hématopoïétique de l’AGM comprend divers types cellulaires incluant des cellules stromales m
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2

Franke, Katja. "Adhesion and Single Cell Tracking of Hematopoietic Stem Cells on Extracellular Matrices." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-77290.

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The local microenvironment of hematopoietic stem cells (HSCs) in the bone marrow -referred to as stem cell niche- is thought to regulate the balance of stem cell maintenance and differentiation by a complex interplay of extrinsic signals including spatial constraints, extracellular matrix (ECM) components and cell-cell interactions. To dissect the role of niche ECM components, a set of well-defined matrix biomolecular coatings including fibronectin, laminin, collagen IV, tropocollagen I, heparin, heparan sulphate, hyaluronic acid and co-fibrils of collagen I with heparin or hyaluronic acid wer
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3

Liu, Wei. "Rational targeting of Cdc42 in hematopoietic stem cell mobilization and engraftment." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1303845649.

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4

Kräter, Martin. "Bone marrow niche-mimetics modulate hematopoietic stem cell function via adhesion signaling in vitro." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230268.

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As graft source for lymphoma or leukemia treatment, hematopoietic stem and progenitor cells (HSPCs) have been the focus of translational medicine for decades. HSPCs are defined by their self-renewing capacity and their ability to give rise to all mature blood cells. They are found anchored to a specialized microenvironment in the bone marrow (BM) called the hematopoietic niche. HSPCs can be enriched by sorting them based on the presence of the surface antigen CD34 before clinical or tissue engineering use. As these cells represent a minority in most graft sources and the amount of applicable c
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Kokkaliaris, Konstantinos [Verfasser], and Heinrich [Akademischer Betreuer] Leonhardt. "Identification of novel niche molecules controlling hematopoietic stem cell behavior / Konstantinos Kokkaliaris ; Betreuer: Heinrich Leonhardt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1115144944/34.

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6

Shimoto, Manabu. "Numerous niches for hematopoietic stem cells remain empty during homeostasis." Kyoto University, 2017. http://hdl.handle.net/2433/226772.

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7

Sugimura, Ryohichi. "Non-canonical Wnt signaling maintains hematopoietic stem cell through Flamingo and Frizzled8 interaction in the niche." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580673.

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Wnt signaling is involved in self-renewal and maintenance ofhematopoietic stem cells (HSCs); however, the particular role of non-canonical Wnt signaling in regulating HSCs in vivo is largely unknown. Here I show Flamingo and Frizzled8, members of non-canonical Wnt signaling, both express in and functionally maintain quiescent long-term HSCs. Flamingo regulates Frizzled8 distribution at the interface between HSCs and N-cadherin + osteoblasts (N-cad+OBs that enrich osteoprogenitors) in the niche. I further show that N-cad+OBs predominantly express non-canonical Wnt ligands and inhibitors of cano
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8

Hazen, Amy L. "Inositol phospholipid and tyrosine phosphorylation signaling in the biology of hematopoietic stem cells." [Tampa, Fla] : University of South Florida, 2009. http://digital.lib.usf.edu/?e14.2829.

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9

Ordemann, Rainer, Duohui Jing, Ana-Violeta Fonseca, et al. "Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-177403.

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Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and ‘stemness’ of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion. Design and Methods In the co-culture system, we defined three distinct l
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10

Ordemann, Rainer, Duohui Jing, Ana-Violeta Fonseca, et al. "Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro." Ferrata Storti Foundation, 2010. https://tud.qucosa.de/id/qucosa%3A28891.

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Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and ‘stemness’ of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion. Design and Methods In the co-culture system, we defined three distinct l
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11

Buglass, Surahanil Katrin. "Regulating stem cell fate within microenvironmental niches." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:75f9498c-30f0-4983-84b2-dd58f2ccf52b.

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Improving the repopulation potential of human umbilical cord blood (UCB) haemopoietic stem cells (HSCs) remains a paramount goal in HSC transplantation (HSCT) therapy. This implies enhancing the homing and engraftment potential of UCB-CD34+CD133+ cells to the bone marrow (BM). Although an array of molecules continues to be identified as ‘key’ homing molecules, the molecular mechanisms controlling HSC homing are still not fully understood. The regulatory implications of hypoxia in the BM, with the concomitant stabilisation of hypoxia inducible transcription factor-1α (HIF-1α), are becoming more
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12

Kräter, Martin [Verfasser], Martin [Akademischer Betreuer] Bornhäuser, and Ben [Gutachter] Wielockx. "Bone marrow niche-mimetics modulate hematopoietic stem cell function via adhesion signaling in vitro / Martin Kräter ; Gutachter: Ben Wielockx ; Betreuer: Martin Bornhäuser." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1144295769/34.

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13

Benedito, Suzana da Silva. "Influência do envelhecimento das células-tronco mesenquimais na autorrenovação, diferenciação e multipotência de células-tronco hematopoéticas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-17112016-162226/.

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O envelhecimento é um processo gradual e intrínseco que ocorre devido a mudanças fisiológicas e fenotípicas com o avanço da idade e que acarreta na diminuição da capacidade de manter a homeostase e reparo tecidual. A perda do controle homeostático e o possível envolvimento de células-tronco e progenitores, provavelmente, é uma das causas das fisiopatologias do sistema hematopoético que acompanham o envelhecimento. O declínio na competência do sistema imune adaptativo, o aumento de doenças mielóides, leucemias e o desenvolvimento de anemias são algumas mudanças significantes e decorrentes do pr
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14

McKinnon, Timothy [Verfasser]. "Hematopoietic Stem / Progenitor Cells and placental vascular development : in vitro study on the role of oxygen and stromal-derived factor-1alpha in the establishment of a stem cell niche / Timothy McKinnon." Gießen : Universitätsbibliothek, 2007. http://d-nb.info/1058561669/34.

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15

Lassailly, François. "Multimodal imaging technologies for identification and characterization of mouse and human hematopoietic stem cell niches in health and disease." Paris 7, 2010. http://www.theses.fr/2010PA077110.

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Afin d'étudier le comportement des cellules leucémiques humaines in-vivo après injection à des souris immunodéficientes, nous avons adapté différentes modalités d'imagerie optique. La bioluminescence permet de suivre de façon quantitative et non invasive la prolifération systémique des cellules et la fluorescence macroscopique fournit des informations structurales et physiologiques. La microscopie intravitale (MIV) du calvarium par confocal / multiphoton permet d'observer les cellules de la moelle osseuse (MO) intacte in vivo et d'analyser les interactions avec leur microenvironnement. Ces tec
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16

Fewkes, Natasha Marie. "Modulation of immune cell niches for therapeutics in cancer and inflammatory diseases." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:cdd4e490-3b49-4f7e-839e-3a48ae34aafe.

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Immune cell niches are microenvironments that support the survival of specific hematopoietic cells. The size of a given niche is dependent on survival and proliferation signals provided. Modulation of niche size can be a useful therapeutic tool, and a better understanding of the factors that control the size of immune cell niches can lead to more targeted therapies. Here bone marrow and thymic niches were modulated with tyrosine kinase inhibition to achieve increased engraftment following stem cell transplantation (SCT). SCT resulting in mixed chimerism is curative for several benign blood dis
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17

Thirupathi, Prabhu [Verfasser], and A. [Akademischer Betreuer] Cato. "The contribution of CD44v6 and CD44v7 to the crosstalk between hematopoietic stem cells and the bone marrow niche / Prabhu Thirupathi. Betreuer: A. Cato." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1064504248/34.

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18

Malfuson, Jean-Valère. "Rôle de la niche mésenchymateuse dans la régulation du phénotype SP des progéniteurs hématopoïétiques humains." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00956760.

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L'hématopoïèse est un processus finement régulé pour permettre sa pérennité et son adaptation aux contraintes physiologiques et pathologiques. Ce potentiel repose en grande partie sur les capacités de quiescence, auto-renouvellement, division asymétrique et multipotence des cellules souches hématopoïétiques (CSH). Les CSH et progéniteurs hématopoïétiques (CSPH) sont principalement régulés de façon extrinsèque au sein des niches hématopoïétiques médullaires et cette régulation fait intervenir, des contacts intercellulaires et des facteurs diffusibles. Le phénotype " side-population " (SP), seco
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19

Burk, Alexandra Serena [Verfasser], and Motomu [Akademischer Betreuer] Tanaka. "Quantifying Adhesion and Morphological Dynamics of Human Hematopoietic Stem and Progenitor Cells on Novel In Vitro Models of Bone Marrow Niche / Alexandra Serena Burk ; Betreuer: Motomu Tanaka." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/118050254X/34.

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20

Garrigou, Philippe. "Etude des effets des rayonnements ionisants sur la niche hématopoïétique et traitement du syndrome aigu d'irradiation par thérapie génique chez le macaque irradié à forte dose." Thesis, Grenoble, 2011. http://www.theses.fr/2011GRENS016/document.

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La niche des cellules souches hématopoïétiques représente un compartiment complexe et radiosensible. Sa protection est nécessaire pour la restauration de l'hématopoïèse faisant suite à la myélosuppression due à l'exposition aux rayonnements ionisants. Nous avons dans un premier temps étudié l'effet des RI sur les progéniteurs endothéliaux et mésenchymateux de la niche par une étude de radiosensiblilité et une étude d'évaluation de la mort cellulaire. Nous avons proposé par la suite une stratégie innovante de thérapie génique basée sur la sécrétion locale et à court terme du morphogène Sonic he
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21

Fievet, Loïc Marc André. "Caractérisation phénotypique et fonctionnelle des cellules stromales mésenchymateuses natives de la moelle osseuse humaine adulte." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30137.

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Au sein de la moelle osseuse (MO), les cellules souches hématopoïétiques (CSH) sont logées dans un microenvironnement en 3D spécialisé, appelé "niche". Cette structure contribue à la régulation du comportement (e.g. auto-renouvellement, engagement dans des voies de différentiation, prolifération et survie). Cette niche est composée de plusieurs types de cellules, comme les cellules endothéliales vasculaires, périvasculaires et ostéoblastiques. Les cellules stromales mésenchymateuses (CSM) périvasculaires jouent un rôle clé dans la formation du microenvironnement, tant par leur expression de fa
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22

Hamdan, Ghassan. "Résistance des cellules souches hématopoïétiques dans la leucémie myéloïde chronique." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10159.

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L’existance de cellules souches leucémiques (CSL) dans la Leucémie Myéloïde Chronique (LMC) prédit que que seule la destruction des CSL conduirait à une guérison. Une proportion importante de patients atteints de LMC développe une résistance aux drogues, environ ~ 30% des cas, Les mécanismes de résistance aux inhibiteurs de tyrosine kinase (TKI) dans la leucémie myéloïde chronique (LMC) restent souvent obscures. Les cellules souches leucémiques de la LMC pourraient rester viables et en repos, malgré la présence de facteurs de croissance ou de médicaments qui semblent les protéger de l'apoptose
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23

Saçma, Mehmet [Verfasser]. "Protective niches for aged hematopoietic stem cells / Mehmet Saçma." Ulm : Universität Ulm, 2019. http://d-nb.info/1201603234/34.

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24

Rhodes, Katrin Elisabeth. "Hematopoietic stem cell development in placental vasculature." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997626891&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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25

Oakley, Erin J. "GENETIC REGULATION OF HEMATOPOIETIC STEM CELL AGING." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/659.

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It is well documented that both quantitative and qualitative changes in the murine hematopoietic stem cell (HSC) population occur with age. In mice, the effect of aging on stem cells is highly strain-specific, thus suggesting genetic regulation plays a role in HSC aging. In C57BL/6 (B6) mice, the HSC population steadily increases with age, whereas in DBA/2 (D2) mice, this population declines. Our lab has previously mapped a quantitative trait locus (QTL) to murine chromosome 2 that is associated with the variation in frequency of HSCs between aged B6 and D2 mice. In these dissertation studies,
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Li, Pulin. "Chemical Genetics of Hematopoietic Stem Cell Transplantation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10306.

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Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. In this thesis, I present the development of a novel live imaging-based competitive marrow repopulation assay in adult zebrafish, which allows fast and quantitative measurement of HSPC engraftment capability. Using this assay, a transplantation-based chemical screen was performed, which led to the discovery of 10 compounds that can enhance the marrow engraftment capability i
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Bilotkach, Kateryna. "Quest for early hematopoietic stem cell precursors." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33056.

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The first transplantable hematopoietic stem cells (HSC) arise in the aorta-gonad mesonephros region (AGM) during early stages of embryo development. Specifically, ventral aspect of embryonic dorsal aorta (DA) contains HSC that upon transplantation into irradiated recipients can reconstitute all lineages of the haematopoietic system [Medvinsky et al. 1993; Muller and Medvinsky, 1994; Medvinsky and Dzierzak, 1996; Cumano et al., 1996; Tavian et al., 1996; Peault and Tavian, 2003; Taoudi and Medvinsky, 2007; Ivanovs et al., 2011, 2014]. The ventral aspect of DA bears so-called intra-aortic cell c
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Knapp, David Jorg Hans Fraser. "Single-cell analysis of hematopoietic stem cell identity and behaviour." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55875.

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The concept of stem cell self-renewal was developed from clonal tracking of hematopoietic stem cell (HSC) divisions in vivo 50 years ago. However, protocols to expand these cells in vitro without loss of their stem cell properties have remained elusive. A number of factors contribute to this inability. Key among these is a lack of knowledge of the critical molecular characteristics that distinguish HSCs from hematopoietic progenitors as well as how the control of the fundamental biological programs of survival, division and differentiation are integrated in HSCs. Using a combination of single-
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Lau, Ka-kit George. "Hepatitis B infection and hematopoietic stem cell transplantation." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/hkuto/record/B31981756.

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30

Omazic, Brigitta. "Immune reconstitution after allogeneic hematopoietic stem cell transplantation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-117-2/.

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31

Reiling, Cassandra. "MRP1: A TARGET FOR HEMATOPOIETIC STEM CELL DISEASES." UKnowledge, 2014. http://uknowledge.uky.edu/toxicology_etds/8.

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Multidrug resistance-associated protein 1 (MRP1) is a member of the adenosine 5’-triphosphate (ATP)-binding cassette (ABC) transporters. MRP1 actively effluxes a variety of endogenous and exogenous substrates from cells, ultimately, working to remove these compounds from the body. MRP1 was initially discovered based on its ability to confer resistance against a variety of chemotherapeutics when overexpressed in cancer cells lines. MRP1 function is important for a number of physiological processes, including regulating cellular and extracellular levels of the anti-inflammatory leukotriene C4 (L
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32

Lau, Ka-kit George, and 廖家傑. "Hepatitis B infection and hematopoietic stem cell transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31981756.

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33

Durand, Ellen Marie. "Regulation of hematopoietic stem cell migration and function." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11550.

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Hematopoietic stem cell transplantation (HSCT) is an effective treatment for blood disorders and autoimmune diseases. Following HSCT, these cells must successfully migrate to the marrow niche and replenish the blood system of the recipient. This process requires both non-cell and cell-autonomous regulation of hematopoietic stem and progenitor cells (HSPCs). A transgenic reporter line in zebrafish allowed the investigation of factors that regulate HSPC migration and function. To directly observe cells in their endogenous microenvironment, confocal live imaging was used to track runx1:GFP+ HSP
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34

João, Cristina Maria Pires. "Immune reconstitution after autologous hematopoietic stem cell transplantation." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5158.

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Abstract The investigation of the web of relationships between the different elements of the immune system has proven instrumental to better understand this complex biological system. This is particularly true in the case of the interactions between B and T lymphocytes, both during cellular development and at the stage of cellular effectors functions. The understanding of the B–T cells interdependency and the possibility to manipulate this relationship may be directly applicable to situations where immunity is deficient, as is the case of cancer or immune suppression after radio and chemot
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35

Onda, Yoshiyuki. "Adenovirus infection after allogeneic hematopoietic stem cell transplantation." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265191.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23419号<br>医博第4764号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 滝田 順子, 教授 杉田 昌彦, 教授 朝長 啓造<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM
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Gilner, Jennifer Bushman Kirby Suzanne Lee. "Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1232.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine.
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Szeto, Ching-ho. "Late complications of haemopoietic stem cell transplantation." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972184.

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Michel, Marcus. "Stem cell regulation in the Drosophila testicular niche." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-121226.

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All multicellular organisms constantly need to replace aged or damaged cells. This vital task of tissue homeostasis is fulfilled by stem cells. The balance between self-renewal and differentiation of the stem cell is crucial for this task and tightly regulated by a signaling microenvironment termed the niche. A widely used model for studying stem cell niche biology is the Drosophila testis, where two stem cell populations, the germline stem cells (GSCs) and the somatic cyst stem cells (CySCs), reside in a niche located at the apical tip. A lot is known about the signals regulating GSC maintena
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39

Yeung, Aaron Ming Hon. "Limbal stem cell niche and ocular surface reconstruction." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580161.

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In the quest to master ocular surface regeneration, one must isolate the stem cells at the limbus and understand them. The stem cell niche is a concept that-was first described in 1978 and subsequently gained interest and became widely accepted. The work presented in Chapter 2 sought to characterize the stem cell niche at the ocular surface, and in doing so led to further understanding of stem cells at the limbus. In Chapter 3 the sampling of infant tissue provided further insight into the niche at that age group. In Chapter 4, Desmoglein 3 was hypothesized to be a negative stem cell marker. F
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40

Tay, Jason. "Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28202.

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Allogeneic Hematopoietic Stem Cell Transplantation is applied in the management of cancer. It involves myeloablative chemoradiotherapy followed by infusion of donor stem cells. The characteristics of the donor stern cells influences transplant outcomes which itself, is dependent on the donor characteristics. The purpose of this thesis was to explore preferences over donor characteristics. A systematic review was performed to identify all donor characteristics associated with outcome. Eight traditional and 5 non-traditional characteristics were identified. The results of the review were used to
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41

Althoff, Mark J. "Cell polarity in hematopoietic stem cell quiescence, signaling and fate determination." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583999632089058.

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42

Szeto, Ching-ho, and 司徒精豪. "Late complications of haemopoietic stem cell transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972184.

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43

Okas, Mantas. "Novel immunotherapeutical strategies in allogeneic hematopoietic stem cell transplantation /." Stockholm : Department of laboratory medicine, Karolinska institutet, 2010. http://diss.kib.ki.se/2010/978-91-7409-934-8/.

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44

Kurth, Ina. "Hematopoietic Stem Cell Differentiation inside Extracellular Matrix functionalized Microcavities." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-68614.

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The bone marrow (BM) niche provides hematopoietic stem (HSC) and progenitor cells with many exogenous cues that tightly regulate homeostasis. These cues orchestrate cellular decisions, which are difficult to dissect and analyze in vivo. This thesis introduces a novel in vitro platform that permits systematic studies of BM-relevant factors that regulate homeostasis. Specifically, the role of 3D patterned adhesion ligands and soluble cytokines were studied in a combinatorial fashion. Analysis of human HSC differentiation and proliferation at both population and single cell level showed synergist
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45

LIANG, YING. "GENETIC REGULATION OF HEMATOPOIETIC STEM CELL NUMBERS IN MICE." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/418.

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Hematopoietic stem cells (HSCs) transplantations are widely used for the treatment of hematological and non-hematological disorders in clinic. Successful transplantation requires sufficient number and efficient homing of HSCs. Many studies have focused on developing an effective strategy to expand functional HSC population. Some regulatory molecules have been recently shown great promise for controlling the amplification of HSCs. In these dissertation studies, I first aim to identify gene(s) and their allelic variants contributing to strain-specific difference in HSC numbers between C57BL/6 (B
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46

Kim, Geon. "Determinants of Embryonic Hematopoietic Stem Cell Emergence and Maturation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:15821585.

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Advances in understanding the developmental origins of hematopoietic stem cell (HSCs)—precisely the molecular mechanisms promoting their emergence and maturation—may lead to derivation of personalized HSCs, circumventing issues of immune mismatch during bone marrow transplantation. In mouse, it is widely accepted that HSCs emerge during mid-gestation from the caudal region of the embryo containing the dorsal aorta, which is called the aorta-gonad-mesonephros (AGM). The emergence occurs through an endothelial intermediate via a phenomenon called the endothelial-to-hematopoietic transition (EHT)
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47

Kanda, Junya. "Analysis of serum hepcidin in hematopoietic stem cell transplantation." Kyoto University, 2010. http://hdl.handle.net/2433/120544.

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48

Ren, Song. "Metabolism of cyclophosphamide : implications for hematopoietic stem cell transplantation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7968.

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49

Wang, Longlong. "A mesenchymal stem cell (MSC) niche in mouse incisor." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/a-mesenchymal-stem-cell-msc-niche-in-mouse-incisor(8f92b75d-f90f-4c58-ab06-682af9f90e95).html.

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Mesenchymal stem cells (MSCs) are heterogeneous cell populations that are identified by their in vitro characteristics while their biological properties and in vivo identities are often less understood. Different from human teeth, mouse incisors grow and erupt continuously throughout their lives and compensate for daily abrasions with the existence of stem cells. However, the precise location of the mesenchymal stem cells (MSCs) in the incisor is unclear. Generally, the MSCs in the mouse incisor are believed to be located in the mesenchyme close to the epithelium cervical loops, since the grow
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50

Young, Sarah Jane. "Biomechanical modelling of the gastrointestinal epithelial stem cell niche." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518236.

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