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Journal articles on the topic 'Hematopoietic stem cell niche'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Wattrus, Samuel J., and Leonard I. Zon. "Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish." Blood Advances 2, no. 21 (2018): 3063–69. http://dx.doi.org/10.1182/bloodadvances.2018021725.

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Abstract Each stem cell resides in a highly specialized anatomic location known as the niche that protects and regulates stem cell function. The importance of the niche in hematopoiesis has long been appreciated in transplantation, but without methods to observe activity in vivo, the components and mechanisms of the hematopoietic niche have remained incompletely understood. Zebrafish have emerged over the past few decades as an answer to this. Use of zebrafish to study the hematopoietic niche has enabled discovery of novel cell–cell interactions, as well as chemical and genetic regulators of h

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2

Ribeiro-Filho, Antonio Carlos, Débora Levy, Jorge Luis Maria Ruiz, Marluce da Cunha Mantovani, and Sérgio Paulo Bydlowski. "Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies." Cells 8, no. 12 (2019): 1628. http://dx.doi.org/10.3390/cells8121628.

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Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified in the bone marrow stem cell niche. Complex interactions between the bone marrow microenvironment and hematopoietic stem cells determine the balance between the proliferation, differentiation and homeostasis of the stem cell compartment. Changes in this tightly regulated network can provoke malignant transform

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Kandarakov, Oleg, Alexander Belyavsky, and Ekaterina Semenova. "Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells." International Journal of Molecular Sciences 23, no. 8 (2022): 4462. http://dx.doi.org/10.3390/ijms23084462.

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The mammalian hematopoietic system is remarkably efficient in meeting an organism’s vital needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over hematopoiesis comes from the regulation of hematopoietic stem cells (HSCs) by specific microenvironments called niches in bone marrow (BM), where HSCs reside. The experimental studies of the last two decades using the most sophisticated and advanced techniques have provided important data on the identity of the niche cells controlling HSCs functions and some mechanisms underlying niche-HSC interactions. In this r

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Goldman, Devorah C., Alexis S. Bailey, Dana L. Pfaffle, Azzah Al Masri, Jan L. Christian, and William H. Fleming. "BMP4 regulates the hematopoietic stem cell niche." Blood 114, no. 20 (2009): 4393–401. http://dx.doi.org/10.1182/blood-2009-02-206433.

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Abstract Bone morphogenetic protein 4 (BMP4) is required for mesoderm commitment to the hematopoietic lineage during early embryogenesis. However, deletion of BMP4 is early embryonically lethal and its functional role in definitive hematopoiesis is unknown. Consequently, we used a BMP4 hypomorph to investigate the role of BMP4 in regulating hematopoietic stem cell (HSC) function and maintaining steady-state hematopoiesis in the adult. Reporter gene expression shows that Bmp4 is expressed in cells associated with the hematopoietic microenvironment including osteoblasts, endothelial cells, and m

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Fielding, Claire, and Simón Méndez-Ferrer. "Neuronal regulation of bone marrow stem cell niches." F1000Research 9 (June 16, 2020): 614. http://dx.doi.org/10.12688/f1000research.22554.1.

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The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of HSCs. It is responsible for orchestrating the fate of HSCs and tightly regulates the processes that occur in the BM, including self-renewal, quiescence, engraftment, and lineage differentiation. However, the BM HSC niche is disturbed following hematological stress such as hematological malignancies, ionizing radiation, and chemotherapy, causing the cellular composition to a

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6

Esmaeli-Azad, Babak, Anand S. Srivastava, Cybele Frederico, Geraldo Martinez, Satoshi Yasukawa, and Ewa Carrier. "Artificial Hematopoietic Stem Cell Niche Sustains Growth and Differentiation of Human ES-Derived Early Hematopoietic Progenitors." Blood 110, no. 11 (2007): 1415. http://dx.doi.org/10.1182/blood.v110.11.1415.1415.

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Abstract Using a novel Microplate Biomaterial Microarray (MBM™) technology, we have created an artificial hematopoietic stem cell niche that can sustain growth and differentiation of human embryonic stem cells-derived (hES) early hematopoietic progenitors. This hydrogel based ex-vivo niche allows uploading of human embryonal stem cells, human mesenchymal stem cells (MSC), genes (bcl-2 preventing apoptosis and HoxB4 enhancing hematopoiesis) and extracellular matrices to support growth and differentiation of human ES cells. These experiments were done using NIH-approved hES cell lines H1 and H9.

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7

Chan, Charles, Ching-Cheng Chen, Daniel L. Kraft, et al. "Identification and Isolation of the Hematopoietic Stem Cell Niche Initiating Cell Population." Blood 112, no. 11 (2008): 3574. http://dx.doi.org/10.1182/blood.v112.11.3574.3574.

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Abstract Introduction: Identification and understanding of the cells and processes that can generate, sustain and influence the HSC niche and hematopoiesis are critical for the development of a more comprehensive knowledge of normal hematopoiesis, stem cell homing, trafficking, differentiation and hematopoietic pathology. Growth and renewal in many tissues are initiated by stem cells, supported by the microenvironment (niche) in which they reside. While recent work has begun to describe functional interactions between stem cells and their niches, little is known about the formation of stem cel

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8

Nishida, Chiemi, Kaori Sato-Kusubata, Yoshihiko Tashiro, et al. "MT1-MMP Plays a Critical Role in Hematopoiesis by Regulating HIF-Mediated Chemo-/Cytokine Gene Transcription within Niche Cells." Blood 120, no. 21 (2012): 2351. http://dx.doi.org/10.1182/blood.v120.21.2351.2351.

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Abstract Abstract 2351 Stem cells reside in a physical niche. The organization of cellular niches has been shown to play a key role in regulating normal stem cell differentiation, stem cell maintenance and regeneration. Various stem cell niches have been shown to be hypoxic, thereby maintaining the stem cell phenotype of e.g. hematopoietic stem cells (HSCs) or cancer stem cells. The bone marrow (BM) niche is a rich reservoir of tissue-specific pluripotent HSCs. Proteases such as matrix metalloproteinases (MMPs) have been implicated in cell movement, partly due to their proteolytic function, an

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9

Boulais, Philip E., and Paul S. Frenette. "Making sense of hematopoietic stem cell niches." Blood 125, no. 17 (2015): 2621–29. http://dx.doi.org/10.1182/blood-2014-09-570192.

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Abstract The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. Anatomic localization of the niche is a dynamic unit from the developmental stage that allows proliferating HSCs to expand before they reach the bone marrow where they adopt a quiescent phenotype that protects their integrity and functions. Recent studies have sought to clarify the complexity behind the HSC niche by assessing the contributions of specific cell populations to HSC maintenance. In part

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10

Park, Dongsu. "The hematopoietic stem cell niche." Frontiers in Bioscience 17, no. 1 (2012): 30. http://dx.doi.org/10.2741/3913.

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11

Frenette, Paul S., Simón Méndez-Ferrer, Daniel Lucas-Alcaraz, et al. "The Hematopoietic Stem Cell Niche." Blood 114, no. 22 (2009): SCI—49—SCI—49. http://dx.doi.org/10.1182/blood.v114.22.sci-49.sci-49.

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Abstract Abstract SCI-49 The concept of stem cell niche, proposed by Schofield 30 years ago, refers to the ability of the microenvironment to regulate stem cell fate. The niche provides critical signals allowing hematopoietic stem cells (HSC) to survive, and if so, whether to remain in or to leave the niche (mobilization), or whether to remain quiescent or divide. Some of these signals originate locally from the niche cell(s) but others are coming from afar. For example, we have found that signals from the sympathetic nervous system (SNS) promote the release of HSCs from the bone marrow (BM) n

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12

Bianco, Paolo. "Minireview: The Stem Cell Next Door: Skeletal and Hematopoietic Stem Cell “Niches” in Bone." Endocrinology 152, no. 8 (2011): 2957–62. http://dx.doi.org/10.1210/en.2011-0217.

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Long known to be home to hematopoietic stem cells (HSC), the bone/bone marrow organ and its cellular components are directly implicated in regulating hematopoiesis and HSC function. Over the past few years, advances on the identity of HSC “niche” cells have brought into focus the role of cells of osteogenic lineage and of marrow microvessels. At the same time, the identity of self-renewing multipotent skeletal progenitors (skeletal stem cells, also known as mesenchymal stem cells) has also been more precisely defined, along with the recognition of their own microvascular niche. The two sets of

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Calvi, Laura M., and Daniel C. Link. "The hematopoietic stem cell niche in homeostasis and disease." Blood 126, no. 22 (2015): 2443–51. http://dx.doi.org/10.1182/blood-2015-07-533588.

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Abstract The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive

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14

Nishida, Chiemi, Kaori Kusubata, Yoshihiko Tashiro, et al. "MT1-MMP Regulates Hematopoiesis Through HIF-Mediated Chemo-/Cytokine Release From the Bone Marrow Niche,." Blood 118, no. 21 (2011): 3409. http://dx.doi.org/10.1182/blood.v118.21.3409.3409.

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Abstract Abstract 3409 Stem cells reside in a physical niche, a particular microenvironment. The organization of cellular niches has been shown to play a key role in regulating normal stem cell differentiation, stem cell maintenance and regeneration. Various stem cell niches have been shown to be hypoxic, thereby maintaining the stem cell phenotype, e.g. for hematopoietic stem cells (HSCs) or cancer stem cells. The bone marrow (BM) niche is a rich reservoir for tissue-specific pluripotent HSCs. Proteases, such as matrix metalloproteinases (MMPs) can modulate stem cell fate due to their proteol

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15

Rahnemoon, Ahmad Reza. "Why Is Importance the Reprogramming and Remodeling In Malignant Hematopoietic Microenvironment and Its Hematopoietic Stem Cells Too." Cancer Research and Cellular Therapeutics 5, no. 2 (2021): 01–04. http://dx.doi.org/10.31579/2640-1053/086.

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Hematopoietic microenvironment or niche keeps stem cells in multi-potent/ uni-potent state which prevents precocious differentiation. The niche employs a variety of factors includes growth factors, cytokines and cell adhesion molecules too. In this section, we try to have a better understanding about the role of hematopoietic stem cells, niche and hematopoiesis as well as we demonstrate that leukemia induced reprogramming initially and then remodeling of the bone marrow (BM) microenvironment which can be a major part of leukemogenesis and is a potential prognostic parameter in malignant hemato

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Mazzon, Cristina, Achille Anselmo, Javier Cibella, et al. "The critical role of agrin in the hematopoietic stem cell niche." Blood 118, no. 10 (2011): 2733–42. http://dx.doi.org/10.1182/blood-2011-01-331272.

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Abstract Hematopoiesis is the process leading to the sustained production of blood cells by hematopoietic stem cells (HSCs). Growth, survival, and differentiation of HSCs occur in specialized microenvironments called “hematopoietic niches,” through molecular cues that are only partially understood. Here we show that agrin, a proteoglycan involved in the neuromuscular junction, is a critical niche-derived signal that controls survival and proliferation of HSCs. Agrin is expressed by multipotent nonhematopoietic mesenchymal stem cells (MSCs) and by differentiated osteoblasts lining the endosteal

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Vodyanoy, Vitaly, Oleg Pustovyy, Ludmila Globa, Randy J. Kulesza, and Iryna Sorokulova. "Hemmule: A Novel Structure with the Properties of the Stem Cell Niche." International Journal of Molecular Sciences 21, no. 2 (2020): 539. http://dx.doi.org/10.3390/ijms21020539.

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Stem cells are nurtured and regulated by a specialized microenvironment known as stem cell niche. While the functions of the niches are well defined, their structure and location remain unclear. We have identified, in rat bone marrow, the seat of hematopoietic stem cells—extensively vascularized node-like compartments that fit the requirements for stem cell niche and that we called hemmules. Hemmules are round or oval structures of about one millimeter in diameter that are surrounded by a fine capsule, have afferent and efferent vessels, are filled with the extracellular matrix and mesenchymal

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Nie, Yuchun, Yoon-Chi Han, and Yong-Rui Zou. "CXCR4 is required for the quiescence of primitive hematopoietic cells." Journal of Experimental Medicine 205, no. 4 (2008): 777–83. http://dx.doi.org/10.1084/jem.20072513.

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The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is known about the extrinsic signals provided by the niche and how these niche signals regulate such a balance. We report that CXCL12 produced by bone marrow (BM) stromal cells is not only the major chemoattractant for HSCs but also a regulatory factor that controls the quiescence of primitive hematopoi

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Bianco, Paolo. "Bone and the hematopoietic niche: a tale of two stem cells." Blood 117, no. 20 (2011): 5281–88. http://dx.doi.org/10.1182/blood-2011-01-315069.

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Abstract The revived interest in (hematopoietic) stem cell (HSC) niches has highlighted the role of multiple cellular players found in the bone environment. Initially focused on the role of osteoblasts and sinusoid endothelial cells, the quest for HSC niche cells has recently focused on a unique role for osteoprogenitor cells (skeletal stem cells, mesenchymal stem cells). Strongly validated by observations of HSC dysregulation dictated by the dysregulation of osteoprogenitors, the role of osteoprogenitors in the HSC niche integrates data from different studies into a unified view. As preosteob

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Hosokawa, Kentaro, Fumio Arai, Hiroki Yoshihara, et al. "Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells." Blood 116, no. 4 (2010): 554–63. http://dx.doi.org/10.1182/blood-2009-05-224857.

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Abstract During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of hematopoietic stem cells (HSCs) in specialized microenvironments termed stem cell niches. Cell-cell and cell-extracellular matrix interactions between HSCs and their niches are critical for the maintenance of HSC properties. Here, we analyzed the function of N-cadherin in the regulation of the proliferation and long-term repopulation activity of hematopoietic stem/progenitor cells (HSPCs) by the transduction of N-cadherin shRNA. Inhibition of N-cadherin expression accelerated cell division in

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Lataillade, Jean-Jacques, Olivier Pierre-Louis, Hans Carl Hasselbalch, et al. "Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence." Blood 112, no. 8 (2008): 3026–35. http://dx.doi.org/10.1182/blood-2008-06-158386.

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Abstract Primary myelofibrosis (PMF) is the rarest and the most severe Philadelphia-negative chronic myeloproliferative syndrome. By associating a clonal proliferation and a mobilization of hematopoietic stem cells from bone marrow to spleen with profound alterations of the stroma, PMF is a remarkable model in which deregulation of the stem cell niche is of utmost importance for the disease development. This paper reviews key data suggesting that an imbalance between endosteal and vascular niches participates in the development of clonal stem cell proliferation. Mechanisms by which bone marrow

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22

Hasan, Tanvir, Ajay Ratan Pasala, Dhuha Hassan, Justine Hanotaux, David S. Allan, and Harinad B. Maganti. "Homing and Engraftment of Hematopoietic Stem Cells Following Transplantation: A Pre-Clinical Perspective." Current Oncology 31, no. 2 (2024): 603–16. http://dx.doi.org/10.3390/curroncol31020044.

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Hematopoietic stem-cell (HSC) transplantation (HSCT) is used to treat various hematologic disorders. Use of genetically modified mouse models of hematopoietic cell transplantation has been critical in our fundamental understanding of HSC biology and in developing approaches for human patients. Pre-clinical studies in animal models provide insight into the journey of transplanted HSCs from infusion to engraftment in bone-marrow (BM) niches. Various signaling molecules and growth factors secreted by HSCs and the niche microenvironment play critical roles in homing and engraftment of the transpla

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Hira, Vashendriya V. V., Jill R. Wormer, Hala Kakar, et al. "Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins." Journal of Histochemistry & Cytochemistry 66, no. 3 (2018): 155–73. http://dx.doi.org/10.1369/0022155417749174.

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In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that HSC niche proteins stromal cell–derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin (OPN), and cathepsin K (CatK) are expressed in hypoxic GSC niches around arterioles in five human glioblastoma samples. In HSC niches, HSCs are retained by binding of SDF-1α and OPN to their receptors CXCR4 and CD44, respectively. Protease CatK cle

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Köhler, Anja, Vince Schmithorst, Marie-Dominique Filippi, et al. "Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones." Blood 114, no. 2 (2009): 290–98. http://dx.doi.org/10.1182/blood-2008-12-195644.

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Abstract Aged hematopoietic stem cells (HSCs) are impaired in supporting hematopoiesis. The molecular and cellular mechanisms of stem cell aging are not well defined. HSCs interact with nonhematopoietic stroma cells in the bone marrow forming the niche. Interactions of hematopoietic cells with the stroma/microenvironment inside bone cavities are central to hematopoiesis as they regulate cell proliferation, self-renewal, and differentiation. We recently hypothesized that one underlying cause of altered hematopoiesis in aging might be due to altered interactions of aged stem cells with the micro

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He, Ningning, Lu Zhang, Jian Cui, and Zongjin Li. "Bone Marrow Vascular Niche: Home for Hematopoietic Stem Cells." Bone Marrow Research 2014 (April 14, 2014): 1–8. http://dx.doi.org/10.1155/2014/128436.

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Though discovered later than osteoblastic niche, vascular niche has been regarded as an alternative indispensable niche operating regulation on hematopoietic stem cells (HSCs). As significant progresses gained on this type niche, it is gradually clear that the main work of vascular niche is undertaking to support hematopoiesis. However, compared to what have been defined in the mechanisms through which the osteoblastic niche regulates hematopoiesis, we know less in vascular niche. In this review, based on research data hitherto we will focus on component foundation and various functions of vas

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Chute, John P. "Regenerative Niche-Hematopoietic Stem Cell Interactions." Blood 136, Supplement 1 (2020): SCI1. http://dx.doi.org/10.1182/blood-2020-133083.

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Kfoury, Youmna, Francois Mercier, and David T. Scadden. "SnapShot: The Hematopoietic Stem Cell Niche." Cell 158, no. 1 (2014): 228–228. http://dx.doi.org/10.1016/j.cell.2014.06.019.

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Arai, Fumio. "Introduction of hematopoietic stem cell niche." Experimental Hematology 43, no. 9 (2015): S28. http://dx.doi.org/10.1016/j.exphem.2015.06.016.

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Camargo, Fernando D. "In vivo Stem Cell Clonal Dynamics." Blood 126, no. 23 (2015): SCI—40—SCI—40. http://dx.doi.org/10.1182/blood.v126.23.sci-40.sci-40.

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Abstract Tremendous progress has been achieved in the characterization of the hematopoietic system over the past two decades. Historically, the main experimental approach used to elucidate and define these cellular relationships in the bone marrow (BM) has been the transplantation assay. For this reason, most of our knowledge about the in vivo properties of hematopoietic stem cells (HSCs) and progenitor cells has been derived from studies in the transplant context. Because of the lack of tractable systems, the mechanistic nature of non-transplant hematopoiesis has remained largely unexplored.

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Stier, Sebastian, Yon Ko, Randolf Forkert, et al. "Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size." Journal of Experimental Medicine 201, no. 11 (2005): 1781–91. http://dx.doi.org/10.1084/jem.20041992.

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Stem cells reside in a specialized niche that regulates their abundance and fate. Components of the niche have generally been defined in terms of cells and signaling pathways. We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment. Osteoblasts that participate in the niche produce varying amounts of OPN in response to stimulation. Using studies that combine OPN-deficient mice and exogenous OPN, we demonstrate that OPN modifies primitive hematopoietic cell number and function in a stem cell–nona

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Gao, Hongjuan, Xiaorong Wu, and Nancy Fossett. "Upregulation of the Drosophila Friend of GATA Gene u-shaped by JAK/STAT Signaling Maintains Lymph Gland Prohemocyte Potency." Molecular and Cellular Biology 29, no. 22 (2009): 6086–96. http://dx.doi.org/10.1128/mcb.00244-09.

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ABSTRACT Studies using Drosophila melanogaster have contributed significantly to our understanding of the interaction between stem cells and their protective microenvironments or stem cell niches. During lymph gland hematopoiesis, the Drosophila posterior signaling center functions as a stem cell niche to maintain prohemocyte multipotency through Hedgehog and JAK/STAT signaling. In this study, we provide evidence that the Friend of GATA protein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation. U-shaped expression was determined to be upregulated in thir

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Ema, Hideo, and Toshio Suda. "Two anatomically distinct niches regulate stem cell activity." Blood 120, no. 11 (2012): 2174–81. http://dx.doi.org/10.1182/blood-2012-04-424507.

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Abstract The niche microenvironment controls stem cell number, fate, and behavior. The bone marrow, intestine, and skin are organs with highly regenerative potential, and all produce a large number of mature cells daily. Here, focusing on adult stem cells in these organs, we compare the structures and cellular components of their niches and the factors they produce. We then define the niche as a functional unit for stem cell regulation. For example, the niche possibly maintains quiescence and regulates fate in stem cells. Moreover, we discuss our hypothesis that many stem cell types are regula

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Akiyama, Haruyo, Leif R. Lund, Yohei Morita, et al. "Novel Functions for a Fibrinolytic Pathway in Controlling the Stem Cell Niche." Blood 108, no. 11 (2006): 1394. http://dx.doi.org/10.1182/blood.v108.11.1394.1394.

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Abstract Hematopoietic stem cells (HSCs) reside within specific niches, where they are maintained by self-renewal and can be mobilized into circulation, but the underlying mechanisms are still unknown. The hematopoietic niche comprises of a local network of stromal cells (like fibroblasts, endothelial cells), accessory cells (T lymphocytes, monocytes), their products (extracellular matrix (ECM) and cytokines, capable of influencing self-renewal, proliferation and differentiation of HSCs. One such ECM molecule is fibrin, which can be found along surfaces in the bone marrow. Its precursor fibrin

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Mansour, Anna, Grazia Abou-Ezzi, Ewa Sitnicka, Sten Eirik W. Jacobsen, Abdelilah Wakkach, and Claudine Blin-Wakkach. "Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow." Journal of Experimental Medicine 209, no. 3 (2012): 537–49. http://dx.doi.org/10.1084/jem.20110994.

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Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM.

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Guerrouahen, Bella S., Ibrahim Al-Hijji, and Arash Rafii Tabrizi. "Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia." Stem Cells International 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/375857.

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Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major elements: endosteal and vascular regulatory elements. The osteoblastic niche localized at the inner surface of the bone cavity might serve as a reservoir for long-term HSC storage in a quiescent state. Whereas the vascular niche, which consists of sinusoidal endothelial cell lining blood vessel, provides an env

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Khlusov, Igor A., Larisa S. Litvinova, Marina Yu Khlusova, and Kristina A. Yurova. "Concept of Hematopoietic and Stromal Niches for Cell-Based Diagnostics and Regenerative Medicine (a Review)." Current Pharmaceutical Design 24, no. 26 (2018): 3034–54. http://dx.doi.org/10.2174/1381612824666180829154119.

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Background: R. Schofield (1978) proposed a hypothesis of hematopoietic stem cells (HSCs) niche (specialized cell microenvironment). An existence of osteoblastic and vascular niches for HSCs has been postulated since 2003. At the same time, the discussion about the existence and functioning of niche for multipotent mesenchymal stromal cells (MMSCs) is just beginning to develop. The design of artificial materials capable of biomimetical reproductionof the cellular and tissue microenvironment based on ideas and main elements borrowed from wildlife is an experimental approach in search of the stem

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Rafii, Shahin, Jason M. Butler, Ginsberg Michael, Jennifer L. Gori, Hans-Peter Kiem, and Scandura Jospeh. "Vascular Niche-Derived Angiocrine Factors Specify and Maintain Hematopoietic Stem Cells." Blood 126, no. 23 (2015): SCI—25—SCI—25. http://dx.doi.org/10.1182/blood.v126.23.sci-25.sci-25.

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Abstract Organ-specific endothelial cells (ECs) are both conduits for delivery of nutrients and also establish an instructive vascular niche. The vascular niche produces paracrine factors, (i.e., angiocrine factors), that balance self-renewal and differentiation of hematopoietic stem/progenitor cells (HSPCs) (1,2). Activation of Akt-mTOR pathway in sinusoidal ECs (SECs) stimulates physiological expression of angiocrine factors, including Kit-ligand, Notch-ligands, Wnts, FGFs, BMPs and TGFb, that expand long-term repopulating HSPCs. Activation of MAPkinase in ECs upregulates expression of GM-CS

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Köhler, Anja, Vince Schmithorst, Marie-Dominique Filippi, et al. "Intravital Imaging of Young and Aged Stem Cells in the Marrow of Long Bones: Visualizing Mammalian Stem Cell Behavior in Real-Time in Vivo." Blood 112, no. 11 (2008): 2418. http://dx.doi.org/10.1182/blood.v112.11.2418.2418.

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Abstract Hematopoiesis, the process in which blood cells are generated from hematopoietic stem and progenitor cells (HSPCs) is primarily confined to the bone cavities. The interactions of hematopoietic cells with stroma cells forming niches inside the bone cavities are central to hematopoiesis, as these regulate cell proliferation, self-renewal and differentiation. Hematopoietic cell/stroma interactions have thus been, in analogy to the immunological synapse, named stem/progenitor cell synapses. So far, visualization of the behavior of somatic stem and progenitor cells in an undisturbed in viv

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Li, Tian, and Yaojiong Wu. "Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche." Bone Marrow Research 2011 (September 22, 2011): 1–8. http://dx.doi.org/10.1155/2011/353878.

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Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation.

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Miura, Yasuo, Zhigang Gao, Masako Miura, et al. "Culture-Expanded Human Bone Marrow Stromal Stem Cells Organize Functional Bone Marrow Niches In Vivo." Blood 106, no. 11 (2005): 2314. http://dx.doi.org/10.1182/blood.v106.11.2314.2314.

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Abstract Bone marrow stromal stem cells (BMSSCs) are mesenchymal stem cells that are capable of differentiating into osteoblasts, chondrocytes, adipocytes, muscle cells and neural cells. Upon in vivo transplantation, BMSSCs form bone and associated hematopoietic marrow elements. However, the functional role of BMSSC-associated bone marrow is still unknown. In this study, we demonstrated that human BMSSCs organized ectopic bone marrow niche microarchitecture that contained hematopoietic progenitors and multiple lineages of cells including myeloid, lymphoid, erythroid and megakaryocytic cells or

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Guidi, Novella, Gina Marka, Vadim Sakk, Yi Zheng, Maria Carolina Florian, and Hartmut Geiger. "An Aged Bone Marrow Niche Restrains Rejuvenated Hematopoietic Stem Cells." Stem Cells 39, no. 8 (2021): 1101–6. http://dx.doi.org/10.1002/stem.3372.

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Abstract Aging-associated leukemia and aging-associated immune remodeling are in part caused by aging of hematopoietic stem cells (HSCs). An increase in the activity of the small RhoGTPase cell division control protein 42 (Cdc42) within HSCs causes aging of HSCs. Old HSCs, treated ex vivo with a specific inhibitor of Cdc42 activity termed CASIN, stay rejuvenated upon transplantation into young recipients. We determined in this study the influence of an aged niche on the function of ex vivo rejuvenated old HSCs, as the relative contribution of HSCs intrinsic mechanisms vs extrinsic mechanisms (

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Yao, Juo-Chin, and Daniel C. Link. "Concise Review: The Malignant Hematopoietic Stem Cell Niche." STEM CELLS 35, no. 1 (2016): 3–8. http://dx.doi.org/10.1002/stem.2487.

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Calvi, Laura M. "Hematopoietic-osteoblastic interactions in the hematopoietic stem cell niche." BoneKEy-Osteovision 3, no. 5 (2006): 10–18. http://dx.doi.org/10.1138/20060210.

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Stier, Sebastian, Yon Ko, Randolf Forkert, et al. "Matrix Glycoprotein Osteopontin Is a Stem Cell Niche Constituent That Constrains the Hematopoietic Stem Cell Pool Size." Blood 104, no. 11 (2004): 664. http://dx.doi.org/10.1182/blood.v104.11.664.664.

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Abstract Stem cells reside in a physical niche where a balance of signals controls their growth, differentiation and death. Niche components have generally been defined in terms of cells and positive effects on stem cell maintenance or expansion. Here we define a role for a matrix glycoprotein that provides a constraining function in the hematopoietic stem cell niche. Osteopontin (OPN) is an abundant glycoprotein in bone that can function as either cytokine or cell adhesion mediator. It is known to be produced by multiple cells types including osteoblasts, cells recently defined to be a regula

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Medyouf, Hind. "The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications." Blood 129, no. 12 (2017): 1617–26. http://dx.doi.org/10.1182/blood-2016-11-696070.

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Abstract Similar to their healthy counterpart, malignant hematopoietic stem cells in myeloid malignancies, such as myeloproliferative neoplasms, myelodysplastic syndromes, and acute myeloid leukemia, reside in a highly complex and dynamic cellular microenvironment in the bone marrow. This environment provides key regulatory signals for and tightly controls cardinal features of hematopoietic stem cells (HSCs), including self-renewal, quiescence, differentiation, and migration. These features are essential to maintaining cellular homeostasis and blood regeneration throughout life. A large number

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Nishida, Chiemi, Kaori Kusubata, Yoshihiko Tashiro, et al. "MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells." Blood 119, no. 23 (2012): 5405–16. http://dx.doi.org/10.1182/blood-2011-11-390849.

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Abstract HSC fate decisions are regulated by cell-intrinsic and cell-extrinsic cues. The latter cues are derived from the BM niche. Membrane-type 1 matrix metalloproteinase (MT1-MMP), which is best known for its proteolytic role in pericellular matrix remodeling, is highly expressed in HSCs and stromal/niche cells. We found that, in MT1-MMP−/− mice, in addition to a stem cell defect, the transcription and release of kit ligand (KitL), stromal cell–derived factor-1 (SDF-1/CXCL12), erythropoietin (Epo), and IL-7 was impaired, resulting in a trilineage hematopoietic differentiation block, while a

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Gonzalez-Nieto, Daniel, Gabriel Ghiaur, Lina Li, et al. "Connexin-43 Regulates the Cell Cycle Entry of Hematopoietic Stem Cells within the Stem Cell Niche." Blood 114, no. 22 (2009): 1500. http://dx.doi.org/10.1182/blood.v114.22.1500.1500.

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Abstract Abstract 1500 Poster Board I-523 Bone marrow (BM) osteoblasts and stromal (O/S) cells are crucial in the establishment of the hematopoietic niches in the BM. Connexin 43 (Cx43) is expressed by BM stromal cells and by hematopoietic stem cells and progenitors (HSC/P) and is overexpressed in the BM endosteal space upon administration of chemotherapy or radiotherapy. We have previously reported that Cx43 is critical in fetal liver and in BM hematopoiesis. Since Cx43 is expressed by both HSC and the hematopoietic microenvironment, we dissected out the cellular mechanisms responsible for Cx

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Suh, Hyung Chan, Ming Ji, John Gooya, Michael Lee, Kimberly Klarmann, and Jonathan R. Keller. "Id1 Provides a Proper Hematopoietic Progenitor Niche Function." Blood 112, no. 11 (2008): 2427. http://dx.doi.org/10.1182/blood.v112.11.2427.2427.

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Abstract Development of hematopoietic stem cells (HSC) and their progeny is maintained by the interaction with cells in the microenvironment. In addition to hematopoietic cells, Id1 is expressed in stromal cells known to support hematopoiesis, and is involved in cell proliferation, differentiation and senescence. Therefore, to investigate the role of Id1 in hematopoiesis, we examined hematologic phenotypes of Id1−/− mice. In this study, we found increased neutrophils and macrophages, and decreased B cells and platelets in peripheral blood, and decreased BM cellularity. While the percentages of

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Arai, Fumio. "Hematopoietic stem cells and niche cell populations." Inflammation and Regeneration 32, no. 4 (2012): 152–57. http://dx.doi.org/10.2492/inflammregen.32.152.

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Day, Ryan B., and Daniel C. Link. "Megakaryocytes in the hematopoietic stem cell niche." Nature Medicine 20, no. 11 (2014): 1233–34. http://dx.doi.org/10.1038/nm.3745.

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