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Journal articles on the topic 'Hematoprotective effect'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Cengiz, Mustafa. "Hematoprotective effect of boron on cyclophosphamide toxicity in rats." Cellular and Molecular Biology 64, no. 5 (2018): 62. http://dx.doi.org/10.14715/cmb/2018.64.5.10.

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2

Al-Mashhadi, Ahmed Mahdi, and Nabeel Mohammed Al-Sharafi. "Hematoprotective Effect of Eugenol against Iron Overload in Male Rats." Kufa Journal For Veterinary Medical Sciences 15, no. 1 (2024): 20–33. http://dx.doi.org/10.36326/kjvs/2024/v15i115324.

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This study aimed to evaluate the hematoprotective effects of eugenol against iron overload in male rats. A total of 30 rats were randomly divided into six equal groups as follows: the control negative (C-) group I.P injection distal water. The control positive (C+) group received iron dextran (100 mg/kg-BW) I.P injection. The IE1 and IE2 groups received iron dextran 100 mg/kg-BW I.P and eugenol (50,100 mg/kg-BW) orally, respectively, and the E3 and E4 groups received eugenol (50,100 mg/kg-BW) orally. After 30 days of the experiment, the blood was collected to measure the experimental parameter

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3

Ayhanci, Adnan, Suzan Yaman, Sila Appak, and Sibel Gunes. "Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats." Drug and Chemical Toxicology 32, no. 4 (2009): 424–28. http://dx.doi.org/10.1080/01480540903130682.

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4

Gökçe Apaydın, Fatma, Dilek Pandır, Suna Kalender, Hatice Baş, and Yusuf Kalender. "Hematoprotective effect of vitamins C and E against subchronic toxicity of bendiocarb: Biochemical evidences." Journal of Food Biochemistry 42, no. 6 (2018): e12659. http://dx.doi.org/10.1111/jfbc.12659.

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5

Kouitcheu, Mabeku Laure Brigitte, Thibau Flaurant Tchouangueu, and Emmanuel Talla. "Antimicrobial, Antioxidant and Protective Effect of Methanol Extract of Trichilia emetica (Meliaceae) Stem and Root Bark against Free Radical-induced Oxidative Haemolysis." European Journal of Medicinal Plants 19, no. 1 (2017): 1–14. https://doi.org/10.9734/EJMP/2017/33343.

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<strong>Background:</strong> The objectives of this study are to investigate the antimicrobial, antioxidant and antiradical properties of methanol extract of the stem and root bark of <em>Trichilia emetica</em> on a model of free radical-induced membrane damage. <strong>Methodology:</strong> p-Iodonitrotetrazolium chloride colorometric assay was used to determined bacterial and yeast susceptibility to plant samples. The antioxidant activity was evaluated using DPPH radical, hydroxyl radical, nitric oxide scavenging and reducing power assays. The cellular oxidative stress was evaluated through

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6

Okugbo, Osarhieme Tinuade, and Ehimwenma Sheena Omoregie. "Anti-plasmodial and Hematological Effects of Methanol Leaf Extract of Ficus capensis in Plasmodium berghei Infected Mice." Bulletins of Natural and Applied Sciences 2, no. 2 (2025): 21–33. https://doi.org/10.5281/zenodo.15477073.

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<strong>Abstract</strong> The plant <em>Ficus capensis</em>, traditionally used in treating ailments such as gonorrhea, dysentery, and fever, has been underexplored for its potential antiplasmodial activity. This study evaluates the antiplasmodial efficacy and hematological effects of the methanol leaf extract of <em>F. capensis</em> on Swiss albino mice (<em>Mus musculus</em>) infected with <em>Plasmodium berghei</em> NK65. Peter's 4-day suppressive test was used to assess the anti-malarial activity following oral administration of the extract. Phytochemical screening identified the presence

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7

Cetik, Songul, Adnan Ayhanci, Yilmaz Altuner, Ahmet Musmul, and Varol Sahinturk. "Hematoprotective Effect of N(G)-Nitro-L-Arginine Methyl Ester and Lycopene on Hematoxicity in Trinitrobenzene Sulfonic Acid-Induced Colitis in Rat." Medicine Science | International Medical Journal 4, no. 4 (2015): 2709. http://dx.doi.org/10.5455/medscience.2015.04.8315.

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8

Zangeneh, Mohammad, Akram Zangeneh, Reza Tahvilian, and Rohallah Moradi. "Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice." Archives of Biological Sciences 70, no. 4 (2018): 655–64. http://dx.doi.org/10.2298/abs180222027z.

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Falcaria vulgaris has been used in medicine as an antimicrobial agent. The aims of this study were to evaluate the hypoglycemic and nephroprotective activities of the aqueous extract of F. vulgaris in diabetic mice. Diabetes was experimentally induced by intraperitoneal injection of streptozotocin (STZ). The mice were divided randomly into 6 groups as follows: nondiabetic, untreated diabetic, a group that received orally 0.5 mg/kg glibenclamide, and three groups that were given orally 200, 600 and 1800 ?g/kg of F. vulgaris, respectively, for 20 days. On the 20th day, the mice were dissected, a

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9

Zangeneh, Mohammad Mahdi, Akram Zangeneh, Reza Tahvilian, et al. "Hepatoprotective and hematoprotective effects of Falcaria vulgaris aqueous extract against CCl4-induced hepatic injury in mice." Comparative Clinical Pathology 27, no. 5 (2018): 1359–65. http://dx.doi.org/10.1007/s00580-018-2747-9.

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10

Wang, Hui, Mao Li, John J. Rinehart, and Ruiwen Zhang. "Dexamethasone as a chemoprotectant in cancer chemotherapy: hematoprotective effects and altered pharmacokinetics and tissue distribution of carboplatin and gemcitabine." Cancer Chemotherapy and Pharmacology 53, no. 6 (2004): 459–67. http://dx.doi.org/10.1007/s00280-003-0759-9.

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11

ibezute, albert emeka. "HEMATOPROTECTIVE, ANTIOXIDANT, AND LIPID-MODULATING EFFECTS OF VERNONIA AMYGDALINA AND CELOSIA ARGENTEA LEAVES IN SODIUM NITRITE (ADMINISTRATERED) TREATED WISTAR RATS." Egyptian Journal of Forensic Sciences and Applied Toxicology 25, no. 2 (2025): 9–20. https://doi.org/10.21608/ejfsat.2025.338209.1356.

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12

Abdallah, Amany A. M., Nasr A. M. Nasr El-Deen, Ahmed N. F. Neamat-Allah, and Heba I. Abd El-Aziz. "Evaluation of the hematoprotective and hepato-renal protective effects of Thymus vulgaris aqueous extract on thermally oxidized oil-induced hematotoxicity and hepato-renal toxicity." Comparative Clinical Pathology 29, no. 2 (2019): 451–61. http://dx.doi.org/10.1007/s00580-019-03078-8.

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13

Tigrine, C., and A. Kameli. "Antioxidant Activity, Phenolic Content and Hematoprotective Effects of Cleome arabica Polyphenolic Leaf Extract." Phytothérapie, 2019. http://dx.doi.org/10.3166/phyto-2019-0206.

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In this study a polyphenolic extract from Cleome arabica leaves (CALE) was investigated for its antioxidant activity in vitro using DPPH•, metal chelating and reducing power methods and for its protective effects against AraC-induced hematological toxicity in vivo using Balb C mice. Results indicated that CALE exhibited a strong and dose-dependent scavenging activity against the DPPH• free radical (IC50 = 4.88 μg/ml) and a high reducing power activity (EC50 = 4.85 μg/ml). Furthermore, it showed a good chelating effects against ferrous ions (IC50 = 377.75 μg/ml). The analysis of blood showed th

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14

Kokila, Subbaian, and Balliah RAGAVAN. "EFFECT OF KAEMPFERIA GALANGA RHIZOME EXTRACT ON HAEMATOLOGICAL PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS." International Journal of Pharmaceutical Sciences and Drug Research, May 30, 2020, 255–59. http://dx.doi.org/10.25004/ijpsdr.2020.120307.

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Diabetes mellitus is a metabolic disorder that is characterized by elevated blood glucose level, altered lipids, carbohydrates and protein metabolism. The present investigation was undertaken to determine the hypoglycemic potential of hydroethanolic extract of Kaempferia galanga rhizome and to assess haematological profile in diabetic rats. Adult male albino rats of Wistar strain were induced with diabetes by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg body weight). Changes in haematological profile reported by STZ induced diabetic rats were found to be restored to normal condi

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15

Erukainure, Ochuko L., Veronica F. Salau, Chika I. Chukwuma, and Shahidul Islam. "Kolaviron: A Biflavonoid with Numerous Health Benefits." Current Pharmaceutical Design 26 (November 13, 2020). http://dx.doi.org/10.2174/1381612826666201113094303.

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Background: The increasing interests on the healing properties of medicinal plants have led to a paradigm shift from the use of synthetic drug to the search of natural medicines for the treatment and management of several diseases. Like other phenolics flavonoids have been continuously explored for their medicinal benefits, with their potent antioxidant activity being a major interest. Kolaviron (KVN) is a biflavonoid isolated from Garcinia kola Heckel, which has been reported for its potent antioxidant and anti-inflammatory properties. These properties have been explored in several disease mo

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16

Onasanwo, Samuel A., Olusegun G. Adebayo, Omeje U. Nicodemus, Abayomi M. Ajayi, A. Wadioni, and I. Wopara. "Hematoprotective and Gastroprotective Effects of Cnidoscolus aconitifolius (Linn)-Supplemented Diet in Male Wistar Rats." Annual Research & Review in Biology, April 18, 2020, 107–18. http://dx.doi.org/10.9734/arrb/2020/v35i230194.

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Aims: Cnidoscolus aconitifolius (CA) is a plant known to possess very high phenolic compound. The study evaluated hematological indices, anti-oxidative properties and gastroprotective potentials of CA leaf-supplemented diet. Methodology: Male Wistar rats weighing between 80-100 g were divided into 5 groups of n=18. Group 1 animals were fed with normal diet and groups 2-5 were fed with diets supplemented with 1%, 2.5%, 5% and 10% of C. aconitifolius powdered leaves continuously for 4, 8 and 12 weeks. Hematological indices were examined in the whole blood plasma Malondialdehyde (MDA), Glut

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17

KULCANAY ŞAHİN, İlknur. "An Investigation into Hematoprotective and Antioxidant Effects of Salvia virgata Jacq. Upon Cyclophosphamide-Induced Toxicity." Journal of the Institute of Science and Technology, June 1, 2022, 589–96. http://dx.doi.org/10.21597/jist.1007441.

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18

Chai, Tsun-Thai, Shin-Yii Ang, Kervine Goh, et al. "Trypsin-hydrolyzed Corn Silk Proteins: Antioxidant Activities, in vitro Gastrointestinal and Thermal Stability, and Hematoprotective Effects." eFood, 2020. http://dx.doi.org/10.2991/efood.k.200323.001.

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19

Matić, Miloš M., Milica G. Paunović, Marija D. Milošević, Branka I. Ognjanović та Zorica S. Saičić. "Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats". Drug and Chemical Toxicology, 18 березня 2019, 1–8. http://dx.doi.org/10.1080/01480545.2019.1587451.

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20

Yildiz, Songul Cetik, Cumali Keskin, Varol Sahintürk, and Adnan Ayhanci. "A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity." Brazilian Archives of Biology and Technology 62 (2019). http://dx.doi.org/10.1590/1678-4324-2019180345.

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21

Miaffo, David, Jacqueline Doudou, Laure Sylviane Kamani Poualeu, et al. "Hepatoprotective, Nephroprotective and Hematoprotective Effects of the Mixture of Cissus polyantha Gilg & Brandt and Rytigynia senegalensis Blume in a Model of Type 2 Diabetes Mellitus." Natural Product Communications 20, no. 6 (2025). https://doi.org/10.1177/1934578x251355349.

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Objective The aim of this work was to evaluate the effects of the mixture of Cissus polyantha and Rytigynia senegalensis (CPRS) on hepatorenal function and oxidative and hematological profiles of diabetic rats. Methods Diabetes was induced by a high-fat diet and streptozotocin (35 mg/kg). Diabetic rats were divided into groups as follws: Groups 1 and 2 received distilled water each; Group 3 received metformin (40 mg/kg); Groups 4 and 5 received CPRS (50 and 111 mg/kg, respectively). Hepatorenal biomarkers, oxidative profile, and hematological parameters were evaluated. Results CPRS caused a de

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22

NUGRAHA, SONY EKA, JANE MELITA KELIAT, MARIANNE, and RONY ABDI SYAHPUTRA. "INVESTIGATING THE TOXICITY OF BETALAIN COMPOUNDS: IN SILICO ANALYSIS AND IN VIVO PREDICTIONS FOR STANDARDIZED BETA VULGARIS L. EXTRACT." International Journal of Applied Pharmaceutics, January 7, 2024, 118–23. http://dx.doi.org/10.22159/ijap.2024v16i1.49189.

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Objective: Extensive research has been conducted on beetroot's antioxidant, hematoprotective, and cardioprotective properties. However, there currently needs to be more available evidence pertaining to the toxicity assessment of the extract. The toxicity assessment was conducted using both in silico and in vivo methods. Prior to testing, the extracts were standardized in accordance with the guidelines set by the Indonesian Food Drug Authority (BPOM), which is the regulatory authority for food and drugs in Indonesia. Methods: The experimental subjects consisted of 25 male Wistar rats in good he

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