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Journal articles on the topic 'Hemodynamic Simulations'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Friedman, Morton H., Heather A. Himburg, and Jeffrey A. LaMack. "Statistical Hemodynamics: A Tool for Evaluating the Effect of Fluid Dynamic Forces on Vascular Biology In Vivo." Journal of Biomechanical Engineering 128, no. 6 (2006): 965–68. http://dx.doi.org/10.1115/1.2354212.

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Background. In vivo experimentation is the most realistic approach for exploring the vascular biological response to the hemodynamic stresses that are present in life. Post-mortem vascular casting has been used to define the in vivo geometry for hemodynamic simulation; however, this procedure damages or destroys the tissue and cells on which biological assays are to be performed. Method of Approach. Two statistical approaches, regional (RSH) and linear (LSH) statistical hemodynamics, are proposed and illustrated, in which flow simulations from one series of experiments are used to define a bes

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2

Stahl, Janneck, Anna Bernovskis, Daniel Behme, Sylvia Saalfeld, and Philipp Berg. "Impact of patient-specific inflow boundary conditions on intracranial aneurysm hemodynamics." Current Directions in Biomedical Engineering 8, no. 1 (2022): 125–28. http://dx.doi.org/10.1515/cdbme-2022-0032.

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Abstract For hemodynamic simulations of intracranial aneurysms boundary conditions (BC) are required. In most cases, these are not patient-specific and thus do not reflect the real flow conditions in the patient. This study investigates the influence of patient-specific inflow BC on intra-aneurysmal hemodynamics. The focus lies on gender and age variations of the patients. To asses the impact, four different inflow curves representing the velocity profile of the inflow over one cardiac cycle is modeled. These four inflow BC are varied in the simulations of each aneurysm from selected subgroups

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Grygoryan, R. D., and T. V. Aksenova. "Simulations of hypertrophied heart’s hemodynamics." PROBLEMS IN PROGRAMMING, no. 2-3 (June 2016): 254–63. http://dx.doi.org/10.15407/pp2016.02-03.254.

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The paper describes the modeling technology and the main results of the simulation of hemodynamic effects of cardiac hypertrophy (HH), conducted using previously published mathematical model (MM) [9]. The dynamics of hemodynamic abnormalities are not modeled. MM simulates changes in the central hemodynamics at different degrees and forms of myocardial hypertrophy (MH). Software technology provides a simulation of three types of HH: a) adaptive HH arising in response to the chronic lack of the systemic circulation; b) abnormal HH, which is at the extreme stage of adaptive HH; c) abnormal MH of

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Popović, Zoran B., Umesh N. Khot, Gian M. Novaro, et al. "Effects of sodium nitroprusside in aortic stenosis associated with severe heart failure: pressure-volume loop analysis using a numerical model." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 1 (2005): H416—H423. http://dx.doi.org/10.1152/ajpheart.00615.2004.

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In the recently published clinical study [Use of Nitroprusside in Left Ventricular Dysfunction and Obstructive Aortic Valve Disease (UNLOAD)], sodium nitroprusside (SNP) improved cardiac function in patients with severe aortic stenosis (AS) and left ventricular (LV) systolic dysfunction. We explored the possible mechanisms of these findings using a series of numerical simulations. A closed-loop lumped parameters model that consists of 24 differential equations relating pressure and flow throughout the circulation was used to analyze the effects of varying hemodynamic conditions in AS. Hemodyna

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Jeken-Rico, Pablo, Aurèle Goetz, Philippe Meliga, Aurélien Larcher, Yigit Özpeynirci, and Elie Hachem. "Evaluating the Impact of Domain Boundaries on Hemodynamics in Intracranial Aneurysms within the Circle of Willis." Fluids 9, no. 1 (2023): 1. http://dx.doi.org/10.3390/fluids9010001.

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Hemodynamic simulations are increasingly used to study vascular diseases such as Intracranial Aneurysms (IA) and to further develop treatment options. However, due to limited data, certain aspects must rely on heuristics, especially at the simulation’s distal ends. In the literature, Murray’s Law is often used to model the outflow split based on vessel cross-section area; however, this poses challenges for the communicating arteries in the Circle of Willis (CoW). In this study, we contribute by assessing the impact of Murray’s Law in patient-specific geometries featuring IA at the posterior co

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Niemann, Annika, Samuel Voß, Riikka Tulamo, et al. "Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images." International Journal of Computer Assisted Radiology and Surgery 16, no. 4 (2021): 597–607. http://dx.doi.org/10.1007/s11548-021-02334-z.

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Abstract Purpose For the evaluation and rupture risk assessment of intracranial aneurysms, clinical, morphological and hemodynamic parameters are analyzed. The reliability of intracranial hemodynamic simulations strongly depends on the underlying models. Due to the missing information about the intracranial vessel wall, the patient-specific wall thickness is often neglected as well as the specific physiological and pathological properties of the vessel wall. Methods In this work, we present a model for structural simulations with patient-specific wall thickness including different tissue types

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Brambila-Solórzano, Alberto, Federico Méndez-Lavielle, Jorge Luis Naude, et al. "Influence of Blood Rheology and Turbulence Models in the Numerical Simulation of Aneurysms." Bioengineering 10, no. 10 (2023): 1170. http://dx.doi.org/10.3390/bioengineering10101170.

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An aneurysm is a vascular malformation that can be classified according to its location (cerebral, aortic) or shape (saccular, fusiform, and mycotic). Recently, the study of blood flow interaction with aneurysms has gained attention from physicians and engineers. Shear stresses, oscillatory shear index (OSI), gradient oscillatory number (GON), and residence time have been used as variables to describe the hemodynamics as well as the origin and evolution of aneurysms. However, the causes and hemodynamic conditions that promote their growth are still under debate. The present work presents numer

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Grygoryan, R. D., A. G. Degoda, T. V. Lyudovyk, and O. I. Yurchak. "Simulations of human hemodynamic responses to blood temperature and volume changes." PROBLEMS IN PROGRAMMING, no. 1 (January 2023): 19–29. http://dx.doi.org/10.15407/pp2023.01.019.

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An advanced version (AV) of special software based on modified quantitative models of mechanisms that provide the overall control of human circulation is proposed. AV essentially expands the range of tasks concerning the modeling of cardiovascular physiology, in particular, the range of mechanisms controlling cardiac function, vascular hemodynamics, and total blood volume under unstable internal/ external physiochemical environments. The models are verified on data representing hemodynamic responses to certain physical tests. In the publication, two test scenarios, namely blood temperature and

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Chen, Yan, Masaharu Kobayashi, Changyoung Yuhn, and Marie Oshima. "Development of a 3D Vascular Network Visualization Platform for One-Dimensional Hemodynamic Simulation." Bioengineering 11, no. 4 (2024): 313. http://dx.doi.org/10.3390/bioengineering11040313.

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Recent advancements in computational performance and medical simulation technology have made significant strides, particularly in predictive diagnosis. This study focuses on the blood flow simulation reduced-order models, which provide swift and cost-effective solutions for complex vascular systems, positioning them as practical alternatives to 3D simulations in resource-limited medical settings. The paper introduces a visualization platform for patient-specific and image-based 1D–0D simulations. This platform covers the entire workflow, from modeling to dynamic 3D visualization of simulation

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Korte, J., P. Groschopp, and P. Berg. "Resolution-based comparative analysis of 4D-phase-contrast magnetic resonance images and hemodynamic simulations of the aortic arch." Current Directions in Biomedical Engineering 9, no. 1 (2023): 650–53. http://dx.doi.org/10.1515/cdbme-2023-1163.

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Abstract Introduction: In this study, phase-contrast magnetic resonance imaging (PC-MRI) 4D flow data for patients with bicuspid aortic valve (BAV) were analyzed based on the spatial resolution of the images. BAV is a congenital heart defect characterized by the presence of two cusps in the aortic valve, leading to various complications. PC-MRI is a noninvasive imaging technique used to assess the hemodynamics in patients. However, interpretation of PC-MRI data can be challenging due to complex hemodynamics, which makes numerical simulations necessary to complement the results. Methods:Within

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Hoi, Yiemeng, Hui Meng, Scott H. Woodward, et al. "Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study." Journal of Neurosurgery 101, no. 4 (2004): 676–81. http://dx.doi.org/10.3171/jns.2004.101.4.0676.

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Object. Few researchers have quantified the role of arterial geometry in the pathogenesis of saccular cerebral aneurysms. The authors investigated the effects of parent artery geometry on aneurysm hemodynamics and assessed the implications relative to aneurysm growth and treatment effectiveness. Methods. The hemodynamics of three-dimensional saccular aneurysms arising from the lateral wall of arteries with varying arterial curves (starting with a straight vessel model) and neck sizes were studied using a computational fluid dynamics analysis. The effects of these geometric parameters on hemody

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Wu, Yihao, Hui Xing, Qingyu Zhang, and Dongke Sun. "Numerical Study on Dynamics of Blood Cell Migration and Deformation in Atherosclerotic Vessels." Mathematics 10, no. 12 (2022): 2022. http://dx.doi.org/10.3390/math10122022.

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A phase field model is used to study the effect of atherosclerotic plaque on hemodynamics. The migration of cells in blood flows is described by a set of multiple phase field equations, which incorporate elastic energies and the interacting effects of cells. Several simulations are carried out to reveal the influences of initial velocities of blood cells, cellular elasticity and block rates of hemodynamic vessels. The results show that the cell deformation increases with the growth of the initial active velocity and block rate but with the decrease of the cellular elasticity. The atherosclerot

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Hyun, S., C. Kleinstreuer, P. W. Longest, and C. Chen. "Particle-Hemodynamics Simulations and Design Options for Surgical Reconstruction of Diseased Carotid Artery Bifurcations." Journal of Biomechanical Engineering 126, no. 2 (2004): 188–95. http://dx.doi.org/10.1115/1.1688777.

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Based on the hypothesis that aggravating hemodynamic factors play a key role in the onset of arterial diseases, the methodology of “virtual prototyping” of branching blood vessels was applied to diseased external carotid artery (ECA) segments. The goals were to understand the underlying particle-hemodynamics and to provide various geometric design options for improved surgical reconstruction based on the minimization of critical hemodynamic wall parameters (HWPs). First, a representative carotid artery bifurcation (CAB) and then CABs with stenosed ECAs, i.e., a distally occluded ECA and an ECA

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Quicken, Sjeng, Barend Mees, Niek Zonnebeld, Jan Tordoir, Wouter Huberts, and Tammo Delhaas. "A realistic arteriovenous dialysis graft model for hemodynamic simulations." PLOS ONE 17, no. 7 (2022): e0269825. http://dx.doi.org/10.1371/journal.pone.0269825.

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Objective The hemodynamic benefit of novel arteriovenous graft (AVG) designs is typically assessed using computational models that assume highly idealized graft configurations and/or simplified boundary conditions representing the peripheral vasculature. The objective of this study is to evaluate whether idealized AVG models are suitable for hemodynamic evaluation of new graft designs, or whether more realistic models are required. Methods An idealized and a realistic, clinical imaging based, parametrized AVG geometry were created. Furthermore, two physiological boundary condition models were

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Al-Jumaily, Ahmed M., Mohammad Al-Rawi, Djelloul Belkacemi, et al. "Computational Modeling Approach to Profile Hemodynamical Behavior in a Healthy Aorta." Bioengineering 11, no. 9 (2024): 914. http://dx.doi.org/10.3390/bioengineering11090914.

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Cardiovascular diseases (CVD) remain the leading cause of mortality among older adults. Early detection is critical as the prognosis for advanced-stage CVD is often poor. Consequently, non-invasive diagnostic tools that can assess hemodynamic function, particularly of the aorta, are essential. Computational fluid dynamics (CFD) has emerged as a promising method for simulating cardiovascular dynamics efficiently and cost-effectively, using increasingly accessible computational resources. This study developed a CFD model to assess the aorta geometry using tetrahedral and polyhedral meshes. A hea

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Gilmanov, Anvar, Alexander Barker, Henryk Stolarski, and Fotis Sotiropoulos. "Image-Guided Fluid-Structure Interaction Simulation of Transvalvular Hemodynamics: Quantifying the Effects of Varying Aortic Valve Leaflet Thickness." Fluids 4, no. 3 (2019): 119. http://dx.doi.org/10.3390/fluids4030119.

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When flow-induced forces are altered at the blood vessel, maladaptive remodeling can occur. One reason such remodeling may occur has to do with the abnormal functioning of the aortic heart valve due to disease, calcification, injury, or an improperly-designed prosthetic valve, which restricts the opening of the valve leaflets and drastically alters the hemodynamics in the ascending aorta. While the specifics underlying the fundamental mechanisms leading to changes in heart valve function may differ from one cause to another, one common and important change is in leaflet stiffness and/or mass.

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Kolachalama, Vijaya B., Neil W. Bressloff, and Prasanth B. Nair. "Mining data from hemodynamic simulations via Bayesian emulation." BioMedical Engineering OnLine 6, no. 1 (2007): 47. http://dx.doi.org/10.1186/1475-925x-6-47.

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Spilker, Ryan L., and Charles A. Taylor. "Tuning Multidomain Hemodynamic Simulations to Match Physiological Measurements." Annals of Biomedical Engineering 38, no. 8 (2010): 2635–48. http://dx.doi.org/10.1007/s10439-010-0011-9.

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Berg, Philipp, Sylvia Saalfeld, Samuel Voß, Oliver Beuing, and Gábor Janiga. "A review on the reliability of hemodynamic modeling in intracranial aneurysms: why computational fluid dynamics alone cannot solve the equation." Neurosurgical Focus 47, no. 1 (2019): E15. http://dx.doi.org/10.3171/2019.4.focus19181.

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Computational blood flow modeling in intracranial aneurysms (IAs) has enormous potential for the assessment of highly resolved hemodynamics and derived wall stresses. This results in an improved knowledge in important research fields, such as rupture risk assessment and treatment optimization. However, due to the requirement of assumptions and simplifications, its applicability in a clinical context remains limited.This review article focuses on the main aspects along the interdisciplinary modeling chain and highlights the circumstance that computational fluid dynamics (CFD) simulations are em

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Korte, Jana, Thomas Rauwolf, Jan-Niklas Thiel, et al. "Hemodynamic Assessment of the Pathological Left Ventricle Function under Rest and Exercise Conditions." Fluids 8, no. 2 (2023): 71. http://dx.doi.org/10.3390/fluids8020071.

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Purpose: The analysis of pathological human left ventricular hemodynamics using high-resolved image-based blood flow simulations shows a major potential for examining mitral valve insufficiency (MI) under exercise conditions. Since capturing and simulating the patient-specific movement of the left ventricle (LV) during rest and exercise is challenging, this study aims to propose a workflow to analyze the hemodynamics within the pathologically moving LV. Methods: Patient-specific ultrasound (US) data of ten patients with MI in different stages were captured with three-dimensional real-time echo

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Xiang, Jianping, Jihnhee Yu, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, and Hui Meng. "Hemodynamic–morphological discriminant models for intracranial aneurysm rupture remain stable with increasing sample size." Journal of NeuroInterventional Surgery 8, no. 1 (2014): 104–10. http://dx.doi.org/10.1136/neurintsurg-2014-011477.

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BackgroundWe previously established three logistic regression models for discriminating intracranial aneurysm rupture status based on morphological and hemodynamic analysis of 119 aneurysms. In this study, we tested if these models would remain stable with increasing sample size, and investigated sample sizes required for various confidence levels (CIs).MethodsWe augmented our previous dataset of 119 aneurysms into a new dataset of 204 samples by collecting an additional 85 consecutive aneurysms, on which we performed flow simulation and calculated morphological and hemodynamic parameters, as

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JANELA, J., A. SEQUEIRA, G. PONTRELLI, S. SUCCI, and S. UBERTINI. "UNSTRUCTURED LATTICE BOLTZMANN METHOD FOR HEMODYNAMIC FLOWS WITH SHEAR-DEPENDENT VISCOSITY." International Journal of Modern Physics C 21, no. 06 (2010): 795–811. http://dx.doi.org/10.1142/s0129183110015488.

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The lattice Boltzmann formulation on unstructured grids (ULBE) is compared against semi-analytical solutions of non-Newtonian flows in straight channels, as well as with finite-element simulations in stenosed geometries. In all cases, satisfactory agreement is found, lending further credit to the ULBE method as a potentially useful method for the numerical simulation of small-scale hemodynamic flows, such as blood flow in capillaries and arterioles.

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Tang, Elaine, Zhenglun (Alan) Wei, Mark A. Fogel, Alessandro Veneziani, and Ajit P. Yoganathan. "Fluid-Structure Interaction Simulation of an Intra-Atrial Fontan Connection." Biology 9, no. 12 (2020): 412. http://dx.doi.org/10.3390/biology9120412.

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Total cavopulmonary connection (TCPC) hemodynamics has been hypothesized to be associated with long-term complications in single ventricle heart defect patients. Rigid wall assumption has been commonly used when evaluating TCPC hemodynamics using computational fluid dynamics (CFD) simulation. Previous study has evaluated impact of wall compliance on extra-cardiac TCPC hemodynamics using fluid-structure interaction (FSI) simulation. However, the impact of ignoring wall compliance on the presumably more compliant intra-atrial TCPC hemodynamics is not fully understood. To narrow this knowledge ga

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Veeturi, Sricharan S., Tatsat R. Patel, Ammad A. Baig, et al. "Hemodynamic Analysis Shows High Wall Shear Stress Is Associated with Intraoperatively Observed Thin Wall Regions of Intracranial Aneurysms." Journal of Cardiovascular Development and Disease 9, no. 12 (2022): 424. http://dx.doi.org/10.3390/jcdd9120424.

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Background: Studying the relationship between hemodynamics and local intracranial aneurysm (IA) pathobiology can help us understand the natural history of IA. We characterized the relationship between the IA wall appearance, using intraoperative imaging, and the hemodynamics from CFD simulations. Methods: Three-dimensional geometries of 15 IAs were constructed and used for CFD. Two-dimensional intraoperative images were subjected to wall classification using a machine learning approach, after which the wall type was mapped onto the 3D surface. IA wall regions included thick (white), normal (pu

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Wu, Wei, Anastasios Nikolaos Panagopoulos, Charu Hasini Vasa, et al. "Patient-specific computational simulation of coronary artery bypass grafting." PLOS ONE 18, no. 3 (2023): e0281423. http://dx.doi.org/10.1371/journal.pone.0281423.

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Introduction Coronary artery bypass graft surgery (CABG) is an intervention in patients with extensive obstructive coronary artery disease diagnosed with invasive coronary angiography. Here we present and test a novel application of non-invasive computational assessment of coronary hemodynamics before and after bypass grafting. Methods and results We tested the computational CABG platform in n = 2 post-CABG patients. The computationally calculated fractional flow reserve showed high agreement with the angiography-based fractional flow reserve. Furthermore, we performed multiscale computational

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Padhee, Swati, Mark Johnson, Hang Yi, Tanvi Banerjee, and Zifeng Yang. "Machine Learning for Aiding Blood Flow Velocity Estimation Based on Angiography." Bioengineering 9, no. 11 (2022): 622. http://dx.doi.org/10.3390/bioengineering9110622.

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Computational fluid dynamics (CFD) is widely employed to predict hemodynamic characteristics in arterial models, while not friendly to clinical applications due to the complexity of numerical simulations. Alternatively, this work proposed a framework to estimate hemodynamics in vessels based on angiography images using machine learning (ML) algorithms. First, the iodine contrast perfusion in blood was mimicked by a flow of dye diffusing into water in the experimentally validated CFD modeling. The generated projective images from simulations imitated the counterpart of light passing through the

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Nixon, Alexander M., Murat Gunel, and Bauer E. Sumpio. "The critical role of hemodynamics in the development of cerebral vascular disease." Journal of Neurosurgery 112, no. 6 (2010): 1240–53. http://dx.doi.org/10.3171/2009.10.jns09759.

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Atherosclerosis and intracranial saccular aneurysms predictably localize in areas with complex arterial geometries such as bifurcations and curvatures. These sites are characterized by unique hemodynamic conditions that possibly influence the risk for these disorders. One hemodynamic parameter in particular has emerged as a key regulator of vascular biology—wall shear stress (WSS). Variations in geometry can change the distribution and magnitude of WSS, thus influencing the risk for vascular disorders. Computer simulations conducted using patient-specific data have suggested that departures fr

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Hoque, K. E., S. Sawall, M. A. Hoque, and M. S. Hossain. "Hemodynamic Simulations to Identify Irregularities in Coronary Artery Models." Journal of Advances in Mathematics and Computer Science 28, no. 5 (2018): 1–19. http://dx.doi.org/10.9734/jamcs/2018/43598.

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Zhang, Qin-Yi, Xiao-Hu Zhou, Xiao-Liang Xie, et al. "A Learning-based Acceleration Framework for Transient Hemodynamic Simulations." Procedia Computer Science 250 (2024): 136–42. https://doi.org/10.1016/j.procs.2024.11.019.

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Jeken-Rico, Pablo, Yves Chau, Aurèle Goetz, Vincent Lannelongue, Jacques Sédat, and Elie Hachem. "Virtual flow diverter deployment and embedding for hemodynamic simulations." Computers in Biology and Medicine 180 (September 2024): 109023. http://dx.doi.org/10.1016/j.compbiomed.2024.109023.

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Fonte, T. A., I. E. Vignon-Clementel, C. A. Figueroa, J. A. Feinstein, and C. A. Taylor. "Three-dimensional simulations of hemodynamic factors in pulmonary hypertension." Journal of Biomechanics 39 (January 2006): S290—S291. http://dx.doi.org/10.1016/s0021-9290(06)84125-4.

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Mansilla Alvarez, L. A., P. J. Blanco, C. A. Bulant, and R. A. Feijóo. "Towards fast hemodynamic simulations in large-scale circulatory networks." Computer Methods in Applied Mechanics and Engineering 344 (February 2019): 734–65. http://dx.doi.org/10.1016/j.cma.2018.10.032.

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Lobachik, V. I., S. V. Abrosimov, V. V. Zhidkov, and D. K. Endeka. "Hemodynamic effects of microgravity and their ground-based simulations." Acta Astronautica 23 (1991): 35–40. http://dx.doi.org/10.1016/0094-5765(91)90097-o.

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Torii, Ryo, Marie Oshima, Toshio Kobayashi, Kiyoshi Takagi, and Tayfun E. Tezduyar. "Influence of wall elasticity in patient-specific hemodynamic simulations." Computers & Fluids 36, no. 1 (2007): 160–68. http://dx.doi.org/10.1016/j.compfluid.2005.07.014.

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BENFOULA, A., L. HAMZA CHERIF, and K. N. HAKKOUM. "EVALUATION OF LEFT VENTRICULAR FILLING PRESSURE USING NUMERICAL MODELING." Journal of Mechanics in Medicine and Biology 20, no. 07 (2020): 2050043. http://dx.doi.org/10.1142/s0219519420500438.

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The main objective of this work is to study the effect of blood pressure and viscosity on flow in a pathological and healthy anatomy. The method chosen for this project is the numerical simulation of fluid dynamics. First, a radiological database from Tlemcen hospital was studied in order to select a patient whose aortic anatomy is representative of the pathology studied in this research project. The left ventricle was segmented using SolidWork software. The exported data made it possible to model this geometry on Comsol software. The geometry has been idealized to make it comparable to a give

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K., E. Hoque, and H. Ali M. "The Impact of Hemodynamic Parameters in 3d Idealized Coronary Artery Normal and Disease Models." Advancement in Mechanical Engineering and Technology 5, no. 1 (2022): 1–15. https://doi.org/10.5281/zenodo.6623346.

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<em>The primary goal of the study that the numerical simulation of </em><em>idealized coronary artery healthy and disease models for detecting coronary abnormality by using the combination of computational fluid dynamics (</em>CFD<em>) and computer design 3D computational models. The simulation results enable of coronary blood flow condition in the idealized coronary artery models which are prototypical patient-based coronary artery models that mimic the original patient-specific coronary artery models. The </em>CFD<em> models study helps to find the flow patterns, mean pressure difference, wa

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Wan Ab Naim, Wan Naimah, Poo Balan Ganesan, Zhonghua Sun, Kok Han Chee, Shahrul Amry Hashim, and Einly Lim. "A Perspective Review on Numerical Simulations of Hemodynamics in Aortic Dissection." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/652520.

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Aortic dissection, characterized by separation of the layers of the aortic wall, poses a significant challenge for clinicians. While type A aortic dissection patients are normally managed using surgical treatment, optimal treatment strategy for type B aortic dissection remains controversial and requires further evaluation. Although aortic diameter measured by CT angiography has been clinically used as a guideline to predict dilation in aortic dissection, hemodynamic parameters (e.g., pressure and wall shear stress), geometrical factors, and composition of the aorta wall are known to substantia

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YANG, Jin You, and Yang Hong. "Numerical Simulations of the Non-Newtonian Blood Blow in Human Abdominal Artery Based on Reverse Engineering." Applied Mechanics and Materials 140 (November 2011): 195–99. http://dx.doi.org/10.4028/www.scientific.net/amm.140.195.

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The method that combined the reverse engineering based on CT medical images and computational fluid dynamics (CFD) was used to perform simulation the Non-Newtonian blood fluid flow in human abdominal artery, then analyzed the hemodynamic condition about the bifurcation of human abdominal artery. A Non-Newtonian blood model (the Generalised Power Law) was used to study the hemodynamic parameters during entire cardiac cycle. Calculated results for the Non-Newtonian blood flow show us the methods performed in this study is suitable for numerical simulating the blood flow in human artery and inves

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Sun, Y., M. Beshara, R. J. Lucariello, and S. A. Chiaramida. "A comprehensive model for right-left heart interaction under the influence of pericardium and baroreflex." American Journal of Physiology-Heart and Circulatory Physiology 272, no. 3 (1997): H1499—H1515. http://dx.doi.org/10.1152/ajpheart.1997.272.3.h1499.

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A phenomenological model of the cardiopulmonary circulation is developed with a focus on the interaction between the right heart and the left heart. The model predicts the hemodynamic consequences of changing circulatory parameters in terms of a broad spectrum of pressure and flow waveforms. Hemodynamics are characterized by use of an electrical analog incorporating mechanisms for transseptal pressure coupling, pericardial volume coupling, intrathoracic pressure, and baroreflex control of heart rate. Computer simulations are accomplished by numerically integrating 28 differential equations tha

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Sharzehee, Mohammadali, Yuan Chang, Jiang-ping Song, and Hai-Chao Han. "Hemodynamic effects of myocardial bridging in patients with hypertrophic cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 6 (2019): H1282—H1291. http://dx.doi.org/10.1152/ajpheart.00466.2019.

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Myocardial bridging (MB) is linked to angina and myocardial ischemia and may lead to sudden cardiac death in patients with hypertrophic cardiomyopathy (HCM). However, it remains unclear how MB affect the coronary blood flow in HCM patients. The aim of this study was to assess the effects of MB on coronary hemodynamics in HCM patients. Fifteen patients with MB (7 HCM and 8 non-HCM controls) in their left anterior descending (LAD) coronary artery were chosen. Transient computational fluid dynamics (CFD) simulations were conducted in anatomically realistic models of diseased (with MB) and virtual

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Korte, Jana, Laurel Marsh, Franziska Gaidzik, Mariya Pravdivtseva, Naomi Larsen, and Philipp Berg. "Correlation of Black Blood MRI with Image- Based Blood Flow Simulations in Intracranial Aneurysms." Current Directions in Biomedical Engineering 7, no. 2 (2021): 895–98. http://dx.doi.org/10.1515/cdbme-2021-2228.

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Abstract Intracranial aneurysms (IA) is not-uncommon pathology of cerebral vessels. Vessel wall magnetic resonance imaging can visualize the vascular walls of IAs. In some aneurysms, the wall-adjacent and a luminal hyperintense signal was detected. The signal was attributed to the inflammation and specific hemodynamic features of aneurysms. But, up to now, the studies investigating luminal enhancement combined with flow analysis are limited. Therefore, in this study, investigation of the luminal enhancement is further carried out by comparison to computational fluid dynamics. The latter provid

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Barahona, José, Alvaro Valencia, and María Torres. "Study of the Hemodynamics Effects of an Isolated Systolic Hypertension (ISH) Condition on Cerebral Aneurysms Models, Using FSI Simulations." Applied Sciences 11, no. 6 (2021): 2595. http://dx.doi.org/10.3390/app11062595.

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Hemodynamics is recognized as a relevant factor in the development and rupture of cerebral aneurysms, so further studies related to different physiological conditions in human represent an advance in understanding the pathology and rupture risk. In this paper, Fluid-structure interaction simulations (FSI) were carried out in six models of cerebral aneurysms, in order to study the hemodynamics effects of an isolated systolic hypertension (ISH) condition and compare it to a normal or normotensive pressure condition and a higher hypertension condition. Interestingly, the ISH condition showed, in

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Arzani, Amirhossein, Ga-Young Suh, Ronald L. Dalman, and Shawn C. Shadden. "A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 12 (2014): H1786—H1795. http://dx.doi.org/10.1152/ajpheart.00461.2014.

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Abdominal aortic aneurysm (AAA) is often accompanied by in traluminal thrombus (ILT), which complicates AAA progression and risk of rupture. Patient-specific computational fluid dynamics modeling of 10 small human AAA was performed to investigate relations between hemodynamics and ILT progression. The patients were imaged using magnetic resonance twice in a 2- to 3-yr interval. Wall content data were obtained by a planar T1-weighted fast spin echo black-blood scan, which enabled quantification of thrombus thickness at midaneurysm location during baseline and followup. Computational simulations

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Talaminos, Alejandro, Laura M. Roa, Antonio Álvarez, and Javier Reina. "Computational Hemodynamic Modeling of the Cardiovascular System." International Journal of System Dynamics Applications 3, no. 2 (2014): 81–98. http://dx.doi.org/10.4018/ijsda.2014040106.

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Computational methods and modeling are widely used in many fields to study the dynamic behaviour of different phenomena. Currently, the use of these models is an accepted practice in the biomedical field. One of the most significant efforts in this direction is applied to the simulation and prediction of pathophysiological conditions that can affect different systems of the human body. In this work, the design and development of a computational model of the human cardiovascular system is proposed. The structure of the model has been built from a physiological base, considering some of the mech

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Uchiyama, Yuya, Soichiro Fujimura, Hiroyuki Takao, et al. "Role of patient-specific blood properties in computational fluid dynamics simulation of flow diverter deployed cerebral aneurysms." Technology and Health Care, January 13, 2022, 1–12. http://dx.doi.org/10.3233/thc-213216.

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BACKGROUND: Hemodynamics and their clinical outcome of cerebral aneurysms treated with flow diverter (FD) stents have thus far been investigated using computational fluid dynamics (CFD) simulations. Although human blood is characterized as a non-Newtonian patientspecific fluid, non-patient-specific blood properties (PSBP) were applied in most extant studies. OBJECTIVE: To investigate the hemodynamic effects caused by PSBPs in aneurysms treated with FD stents. METHODS: We measured blood properties (density and viscosity) for 12 patients who underwent FD stent deployment. We conducted CFD simula

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An, Senyou, Huidan Yu, MD Mahfuzul Islam, et al. "Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-48631-2.

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AbstractEvidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconst

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Shi, Liuliu, Xinru Xiang, Jinlong Liu, and Wei Zhu. "Numerical study of the effect of stenosis on the hemodynamics of a popliteal artery." AIP Advances 15, no. 2 (2025). https://doi.org/10.1063/5.0245958.

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The investigation of flow characteristics within the popliteal artery is fundamental to understanding the progression of lower limb arterial disease, given its high susceptibility to atherosclerosis and its frequent manifestation of stenosis. Research on the hemodynamics associated with popliteal artery stenosis remains limited, particularly in cardiovascular diseases. This study comprehensively examines how Newtonian and non-Newtonian fluid models influence the hemodynamic simulations of popliteal artery stenosis. Key hemodynamic parameters, such as velocity, time-averaged wall shear stress (

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Wu, Mingwei, Li Liu, and Jiang Xiong. "In Vitro Studies on Hemodynamics of Type B Aortic Dissection: Accuracy and Reliability." Journal of Endovascular Therapy, June 21, 2023. http://dx.doi.org/10.1177/15266028231182229.

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Type B aortic dissection (TBAD) is associated with high mortality. Multiple in vitro models and computational fluid dynamics (CFD) simulations have been used to mimic the hemodynamic characteristics of TBAD to inform more effective therapeutic strategies. However, the results of these experiments are rarely used in clinical practice due to concerns about their accuracy and reliability. The development of 4-dimensional magnetic resonance imaging (4D-MRI) allows to verify the accuracy of the results of in vitro models and CFD simulations. This review provides an overview of the strengths, limita

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Chang Ruan, Qi Yu, Jingyuan Zhou, Xinying Ou, Yi Liu, and Yu Chen. "Fluid–structure interaction simulation for studying hemodynamics and rupture risk of patient-specific intracranial aneurysms." Acta of Bioengineering and Biomechanics 25, no. 3 (2023). http://dx.doi.org/10.37190/abb-02247-2023-03.

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Purpose The role of regional hemodynamics in intracranial aneurysms (IAs) hemodynamics and rupture risk has been widely discussed based on numerical models over the past decades. The aim of this paper is to investigate hemodynamics and rupture risk with a complicated IA model. Methods Fluid-structure interaction (FSI) simulations were performed to quantify the hemodynamic characteristics of the established IA models. Hemodynamic parameters, including wall shear stress (WSS), flow velocity, and flow pattern, were calculated and analyzed. Results In this paper, the risk assessment of intracrania

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Hu, Mengqiang, Bing Chen, and Yuanming Luo. "Computational fluid dynamics modelling of hemodynamics in aortic aneurysm and dissection: a review." Frontiers in Bioengineering and Biotechnology 13 (March 21, 2025). https://doi.org/10.3389/fbioe.2025.1556091.

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Hemodynamic analysis based on computational fluid dynamics (CFD) modelling is expected to improve risk stratification for patients with aortic aneurysms and dissections. However, the parameter settings in CFD simulations involve considerable variability and uncertainty. Additionally, the exact relationship between hemodynamic features and disease progression remains unclear. These challenges limit the clinical application of aortic hemodynamic models. This review presents a detailed overview of the workflow for CFD-based aortic hemodynamic analysis, with a focus on recent advancements in the f

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