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Rutherford-Parker, Nicola J., Sean T. Campbell, Jennifer M. Colby, and Zahra Shajani-Yi. "Voxelotor Treatment Interferes With Quantitative and Qualitative Hemoglobin Variant Analysis in Multiple Sickle Cell Disease Genotypes." American Journal of Clinical Pathology 154, no. 5 (2020): 627–34. http://dx.doi.org/10.1093/ajcp/aqaa067.
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Abstract Objectives Voxelotor was recently approved for use in the United States as a treatment for sickle cell disease (SCD) and has been shown to interfere with the quantitation of hemoglobin (Hb) S percentage. This study aimed to determine the effect of voxelotor on the quantitation of hemoglobin variant levels in patients with multiple SCD genotypes. Methods In vitro experiments were performed to assess the impact of voxelotor treatment on hemoglobin variant testing. Whole blood samples were incubated with voxelotor and then analyzed by routinely used quantitative and qualitative clinical laboratory methods (high-performance liquid chromatography [HPLC], capillary zone electrophoresis [CZE], and acid and alkaline electrophoresis). Results Voxelotor modified the α-globin chain of multiple hemoglobins, including HbA, HbS, HbC, HbD-Punjab, HbE, HbA2, and HbF. These voxelotor-hemoglobin complexes prevented accurate quantitation of multiple hemoglobin species, including HbS, by HPLC and CZE. Conclusions Technical limitations in quantifying HbS percentage may preclude the use of HPLC or CZE for monitoring patients treated with voxelotor. Furthermore, it is unclear whether HbS-voxelotor complexes are clinically equivalent to HbS. Consensus guidelines for reporting hemoglobin variant percentages for patients taking voxelotor are needed, as these values are necessary for determining the number of RBC units to exchange in acute situations.
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Bimantara, Gama, Angga Hardiansyah, and Darmu’in. "Hubungan Status Gizi, Persen Lemak Tubuh, dan Kadar Hemoglobin Terhadap Kualitas VO2 Maks Siswa Sekolah Sepak Bola Sport Supaya Sehat Semarang." Jurnal Gizi 12, no. 1 (2023): 20. http://dx.doi.org/10.26714/jg.12.1.2023.20-26.
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Background: Have a good nutritional status, ideal body fat percentage and normal hemoglobin levels are needed for maintain physical endurance, physical fitness and help to improve the performance of football athletes. When the nutritional status and body fat levels are not ideal, it will interfere athlete mobility. Low hemoglobin levels could disrupt the metabolism of energy that can make an athlete have downgrade quality. Purpose: Know the relationship of nutritional status, body fat percentage, and hemoglobinlevels on the quality of VO2 max student levels from Sport Supaya Sehat (SSS) football school Semarang. Methods: This research was conducted with a cross sectional design at Sport Supaya Sehat (SSS) football school Semarang. All population is a sample which is has 56 respondent. Themeasured data are nutritional status was assessed with body mass index by age, body fat percentage was assessed using Bioelectrical Impedance Analysis, hemoglobin levels was measured using Easytouch GCHb tools and cardiorespiratory endurance was assessed using Yo-Yo test method. Bivariate analysis used Gamma test. Result: The majority characteristics of respondents are have a good nutritional status(69,6%), moderate fat percentages(62,5%), normal hemoglobin levels(71,4%), and good quality of VO2 max levels(55,4%). Bivariate analitical result are nutritional status and body fat percentage has no significant relationship with VO2 max quality levels (p>0,05). Hemoglobin level has significant relationship with VO2 max quality levels (p<0,05). Conclusion: There is a significant relationship between hemoglobin levels with VO2 max quality levels.Key words: Nutritional status; body fat percentage; hemoglobin; VO2 max
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Moscoso, H., C. R. Kiefer, A. Kutlar, and F. A. Garver. "Quantification of hemoglobins S, C, and F by a magnetic affinity immunoassay." Clinical Chemistry 34, no. 5 (1988): 902–5. http://dx.doi.org/10.1093/clinchem/34.5.902.
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Abstract This magnetic affinity immunoassay (MAIA) quantifies hemoglobins (Hb) S, C, and F in hemolysates from adults or newborns. Monospecific antisera to the hemoglobins are covalently conjugated to magnetic beads and reacted with the corresponding 125I-labeled hemoglobin. After centrifugation to separate the free and antibody-bound 125I-labeled hemoglobin, the amount of radioactive hemoglobin in the pellet is measured. To determine the concentration of the Hb under study, the percent inhibition of the reaction is quantified. The standard curve is established by adding known quantities of unlabeled hemoglobin before adding 125I-labeled hemoglobin. The amount of Hb S, Hb C, or Hb F present in hemolysates is determined by measuring the percentage of inhibition and extrapolating the concentration from the standard curve. Results agree well with values for Hb S and Hb C obtained by "high-performance" liquid chromatography and RIA and for Hb F as measured by alkali denaturation and RIA. This assay can be completed in 1 h and is more sensitive than enzyme immunoassay or RIA: we can detect proportions of Hb S and Hb C as low as 1% of total Hb, and Hb F as low as 0.05%.
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LOTTRUP, M. C., and H. LEBEL. "On Determination of the Hemoglobin Percentage from the Sedimentation Rate1." Acta Medica Scandinavica 82, no. 1-2 (2009): 170–72. http://dx.doi.org/10.1111/j.0954-6820.1934.tb09397.x.
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Scabet, Michael, Cheryl J. Mcroyan, J. Grace Liu, Richard C. Morris, and Paul I. Liu. "A Rapid Assessment of Percentage Hemoglobin-S in Whole Blood." American Journal of Clinical Pathology 86, no. 6 (1986): 759–61. http://dx.doi.org/10.1093/ajcp/86.6.759.
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Purvis, Taylor E., C. Rory Goodwin, Camilo A. Molina, Steven M. Frank, and Daniel M. Sciubba. "Percentage change in hemoglobin level and morbidity in spine surgery patients." Journal of Neurosurgery: Spine 28, no. 3 (2018): 345–51. http://dx.doi.org/10.3171/2017.7.spine17301.
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OBJECTIVEThe aim of this study was to characterize the association between percentage change in hemoglobin (ΔHb)—i.e., the difference between preoperative Hb and in-hospital nadir Hb concentration—and perioperative adverse events among spine surgery patients.METHODSPatients who underwent spine surgery at the authors’ institution between December 4, 2008, and June 26, 2015, were eligible for this retrospective study. Patients who underwent the following procedures were included: atlantoaxial fusion, subaxial anterior cervical fusion, subaxial posterior cervical fusion, anterior lumbar fusion, posterior lumbar fusion, lateral lumbar fusion, excision of intervertebral disc, and excision of spinal cord lesion. Data on intraoperative transfusion were obtained from an automated, prospectively collected, anesthesia data management system. Data on postoperative hospital transfusions were obtained through an Internet-based intelligence portal. Percentage ΔHb was defined as: ([preoperative Hb − nadir Hb]/preoperative Hb) × 100. Clinical outcomes included in-hospital morbidity and length of stay associated with percentage ΔHb.RESULTSA total of 3949 patients who underwent spine surgery were identified. Of these, 1204 patients (30.5%) received at least 1 unit of packed red blood cells. The median nadir Hb level was 10.6 g/dl (interquartile range 8.7–12.4 g/dl), yielding a mean percentage ΔHb of 23.6% (SD 15.4%). Perioperative complications occurred in 234 patients (5.9%) and were more common in patients with a larger percentage ΔHb (p = 0.017). Hospital-related infection, which occurred in 60 patients (1.5%), was also more common in patients with greater percentage ΔHb (p = 0.001).CONCLUSIONSPercentage ΔHb is independently associated with a higher risk of developing any perioperative complication and hospital-related infection. The authors’ results suggest that percentage ΔHb may be a useful measure for identifying patients at risk for adverse perioperative events.
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Nakazawa, M., MT Mitjavila, N. Debili, et al. "KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation." Blood 73, no. 7 (1989): 2003–13. http://dx.doi.org/10.1182/blood.v73.7.2003.2003.
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Abstract A human leukemic cell line KU 812 was recently established and described as a basophilic cell line. In the present study we show that KU 812 and two of its clones are at least bipotent: in addition to a minor component of basophils, the majority of KU 812 cells belongs to the erythroid cell lineage with a significant percentage (about 15%) of mature hemoglobinized erythroblasts. This terminal differentiation is associated with the synchronized synthesis of the main erythroid proteins, including glycophorins, spectrin beta chain, band 3, and hemoglobin. The predominant hemoglobins are adult, fetal, and Bart's hemoglobin. Adult hemoglobin represented up to 75% of all hemoglobins in the KU 812 F clone in passages containing a high number of mature erythroblasts. Transcripts of all human globin chains were present with ten times less embryonic chain messenger RNA (mRNA) than alpha-, beta- or gamma-chain mRNA. Hemin slightly increased the total hemoglobin production of the cell line, especially gamma-globin chain synthesis, but did not modify the percentage of hemoglobinized cells. Phorbol myristate acetate (PMA) had a complex effect, inducing a proportion of KU 812 cells to adhere to the plastic culture flask. The adherent cell fraction expressed a very low level of specific erythroid proteins, but their ultrastructure was consistent with immature erythroid cells. In contrast, approximately 40% of the nonadherent cells were mature erythroid cells. Cell-sorting experiments showed that this paradoxic effect of PMA is mostly due to cell selection, the more mature cells being unable to adhere. In addition, KU 812 F was found to be sensitive to erythropoietin, which slightly increased its plating efficiency range (from 0% to 50%) in semisolid medium and enhanced hemoglobin accumulation twofold. In binding experiments using 125I erythropoietin, a single class of high-affinity Epo receptors (Kd: 250 pM) was detected by binding with a density of 205 receptors per cell. The KU 812 cell line is therefore a unique model for studying cell commitment toward different hematopoietic lineages and erythroid differentiation.
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Nakazawa, M., MT Mitjavila, N. Debili, et al. "KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation." Blood 73, no. 7 (1989): 2003–13. http://dx.doi.org/10.1182/blood.v73.7.2003.bloodjournal7372003.
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A human leukemic cell line KU 812 was recently established and described as a basophilic cell line. In the present study we show that KU 812 and two of its clones are at least bipotent: in addition to a minor component of basophils, the majority of KU 812 cells belongs to the erythroid cell lineage with a significant percentage (about 15%) of mature hemoglobinized erythroblasts. This terminal differentiation is associated with the synchronized synthesis of the main erythroid proteins, including glycophorins, spectrin beta chain, band 3, and hemoglobin. The predominant hemoglobins are adult, fetal, and Bart's hemoglobin. Adult hemoglobin represented up to 75% of all hemoglobins in the KU 812 F clone in passages containing a high number of mature erythroblasts. Transcripts of all human globin chains were present with ten times less embryonic chain messenger RNA (mRNA) than alpha-, beta- or gamma-chain mRNA. Hemin slightly increased the total hemoglobin production of the cell line, especially gamma-globin chain synthesis, but did not modify the percentage of hemoglobinized cells. Phorbol myristate acetate (PMA) had a complex effect, inducing a proportion of KU 812 cells to adhere to the plastic culture flask. The adherent cell fraction expressed a very low level of specific erythroid proteins, but their ultrastructure was consistent with immature erythroid cells. In contrast, approximately 40% of the nonadherent cells were mature erythroid cells. Cell-sorting experiments showed that this paradoxic effect of PMA is mostly due to cell selection, the more mature cells being unable to adhere. In addition, KU 812 F was found to be sensitive to erythropoietin, which slightly increased its plating efficiency range (from 0% to 50%) in semisolid medium and enhanced hemoglobin accumulation twofold. In binding experiments using 125I erythropoietin, a single class of high-affinity Epo receptors (Kd: 250 pM) was detected by binding with a density of 205 receptors per cell. The KU 812 cell line is therefore a unique model for studying cell commitment toward different hematopoietic lineages and erythroid differentiation.
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., Sambedna, Amit Kumar, and Rita Chakore. "Study of relationship between umbilical cord blood hemoglobin percentage and perinatal asphyxia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 10 (2020): 4114. http://dx.doi.org/10.18203/2320-1770.ijrcog20204297.
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Background: Perinatal asphyxia may be caused by perinatal anemia. The pathophysiology and neurodevelopment effects are theoretically different from other causes of fetal asphyxia. Severe asphyxia can occur in infants around the time of birth by various reasons. The aim of this study to find the relationship between cord blood hemoglobin and perinatal asphyxia.Methods: This was a retrospective comparative study in department of OBG In tertiary care health centre. Umbilical cord blood samples were collected from 100 newborns with asphyxia at birth as study group and 100 newborns with non asphyxia as control group. Hemoglobin was measured colorimetrically.Results: This study finds that maximum number of patients in both the control and study group had hemoglobin in the range of 16.3-17.3 gm/dl. The difference was not statistically significant. P value>0.05.Conclusions: Hematological changes observed early after delivery can determine the duration of hypoxemia (acute versus chronic) Perinatal anemia causing moderate to severe perinatal asphyxia is associated with a higher risk for neonatal mortality. All survivors with perinatal anemia, however, showed no abnormalities in neurodevelopment in contrast to children who were born asphyxiated due to various another causes. The underlying pathophysiological mechanism for the favorable NDO in the perinatal anemia group needs further elucidation.
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Alkattan, Abdullah N., Ahmed S. Alkhalifah, and Eman A. Alsalameen. "The Effect of Glycated Hemoglobin on the Prognosis of Diabetic Patients: A Cross-Sectional Observational Study." Saudi Journal of Internal Medicine 9, no. 1 (2019): 5–11. http://dx.doi.org/10.32790/sjim.2019.9.1.2.
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Objectives: Diabetes mellitus is a chronic metabolic disorder characterized by elevation of blood glucose and a high percentage of glycated hemoglobin A1c. Elevated hemoglobin A1c percentage of more than 7% will result in high production of advanced glycation end-products. Th e elevated level of advanced glycation end-products in diabetic patients means a high risk for diabetic complications. Th e primary endpoint was to evaluate the hemoglobin A1c levels among diabetic patients and its effect on the prognosis of this metabolic disease in all regions inside Saudi Arabia.
 Methods: Th is was a cross-sectional observational study conducted between March and August 2018. Th e study was done by using a questionnaire containing nine questions which planned to involve at least 390 diabetic patients.
 Results: Six hundred and ninety-four diabetic patients from Saudi Arabia had answered the nine-question questionnaire about hemoglobin A1c percentage and prognosis of diabetes. Th e mean age of these patients is 43.4 years old and most of those patients (75.5%) were visiting governmental hospitals. Th e number of diabetic patients having hemoglobin A1c less than 7% are 259 patients with hemoglobin A1c mean 6.66% + 3.33%, however, there are 435 patients having hemoglobin A1c more than 7% with mean equals 7.75% + 1.2%, the difference between them is statistically significant (P value < 0.0001).
 Conclusion: Th e glycated hemoglobin of diabetic patients in all regions of Saudi Arabia was significantly elevated and uncontrolled based on most diabetic guidelines and significantly affects the prognosis by causing diabetic complications especially cardiovascular diseases.
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الطويل, عبد العالي خليفة علي, سعاد محمد كرور, اية إبراهيم الكمجاجي та رتاج عامر الشوشان. "دراسة تقييم الإصابة بطفيل المتحولة الحالة للنسج وعلاقتها بمستوى الهيموجلوبين وعدد كريات الدم البيضاء". International Science and Technology Journal 35, № 1 (2024): 1–11. https://doi.org/10.62341/asar1002.
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This study was conducted to determine the incidence of the histolytic encephalopathy and its relationship to some blood variables (hemoglobin and white blood cells). A number of (120) samples were collected from the general records of Zawia Teaching Hospital from the period (January 2023-December 2023) in the children's department, in addition to examining some samples of shelter cases in the children's department, where we relied on the direct stain method to examine stool samples. The results showed that the most infected age groups are the ages between (6 years - 10 years) at a rate of (19%), in addition to the fact that the most infected gender was females at a rate of (64%), in addition to the fact that it was noted that the infected had a slight deficiency in the hemoglobin percentage, which indicates that the infections were not severe, in addition to the fact that the percentage of white blood cells was (14%), which is considered a high percentage compared to the normal percentage, and the percentage of non-infected indicates that the children's immunity was good and the infection was simple. Keywords: Entamoeba histolytica parasite, infection, relationship, hemoglobin level, white blood cells.
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WEBBER, BRYANT J., COLBY C. UPTEGRAFT, NATHANIEL S. NYE, and Francis G. O’Connor. "Association of Sickle Cell Trait and Hemoglobin S Percentage with Physical Fitness." Medicine & Science in Sports & Exercise 50, no. 12 (2018): 2488–93. http://dx.doi.org/10.1249/mss.0000000000001720.
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Rangan, Aruna, Kenneth C. Swanson, Molly S. Hein та ін. "Novel Double Fusion (βδβ) Hemoglobin Variant with Comparison to Lepore Hemoglobins". Blood 142, Supplement 1 (2023): 5328. http://dx.doi.org/10.1182/blood-2023-189831.
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Lepore hemoglobins (Hbs) such as Hb Lepore-Boston-Washington [δ(1-87) β(116-146)], Hb Lepore-Baltimore [δ(1-50) β(86-146)], Hb Lepore-Hollandia [δ(1-22) β(50-146)] are δβ gene fusion/deletion variants (ε- Gγ- Aγ-[δβ] v )(Figure 1). They are controlled by the weak δ-globin gene promoter and synthesized at approximately 10-15% of hemoglobin fractions. This results in a similar phenotype as β +-thalassemia (microcytosis and hypochromia ± mild anemia). Anti-Lepore hemoglobins such as Hb P-Nilotic (β(1-22) δ(50-146) are βδ gene fusion/duplication variants (ε- Gγ- Aγ-δ-[βδ] v-β) associated with normal CBC values. Herein we describe a novel βδβ double fusion variant (ε- Gγ- Aγ-δ-[βδβ] v). Due to high homology between the δ and β genes, this double fusion event encodes an identical protein to Hb Lepore-Hollandia, albeit linked to the β-promoter and therefore expressed at ~40% of hemoglobin fractions, which would be expected to enhance any intrinsic properties of the variant. This novel hemoglobin variant is named Hb Lepore Rochester-MN. Two cases have been identified (Table 1). Case 1 was a 10-month-old Caucasian/Native American infant referred for an abnormal newborn screen and a reported family history of Hb G-Coushatta (β22, GAA&gt;GCA, Glu&gt;Ala; HGVS: c.68A&gt;C, p.E23A). Case 2 was a 3-month-old infant referred for an abnormal newborn screen. CBCs were normal for age including MCV. Cation-exchange high performance liquid chromatography (HPLC) showed a shouldered peak in the Hb A 2 window typical for Hb Lepore (elution time: 3.41-3.46 mins), although the variant percentage was higher than expected, mimicking Hb G-Coushatta (expected elution time: 3.33 mins). Capillary electrophoresis identified a peak in the D zone (Z(D) zone), which is expected for Hb Lepore or Hb G-Coushatta. Intact mass spectrometry was consistent with Hb Lepore-Hollandia at 15836 amu, differing from Hb G-Coushatta (Glu&gt;Ala, 15809 amu). Multiplex ligand probe amplification (MLPA) was normal because the highly variable fusion regions are unsuitable for probe placement. Sanger sequencing of the β-globin gene identified multiple single base substitutions which were challenging to interpret but matched the sequence expected for a complex double crossover event (NM_000518.4:c.28_68delins41 (p.Ser10_Glu23delins14TAVNALWGKVNVDA). The first crossover is located between c.-29 and c.9, the second crossover is located between c.69 and c.92+17. Long-read sequencing was performed (Sequel, Pacific Biosciences) which detected the multiple missense mutations in cis conformation, as was corroborated by the mass spectrometry data. In summary, Hb Lepore Rochester-MN represents a novel double fusion [βδβ] variant class that will pose a diagnostic challenge for laboratories. Although it is likely a result of sequential crossover events (deletion and duplication) between Lepore and anti-Lepore variants, MLPA analysis is normal due to technical constraints and high homology. DNA sequencing (both Sanger and long read methods) yielded complex results that require sophisticated analysis and correlation with protein data including intact mass spectrometry. HPLC and CE data including variant percentage are very similar to Hb G-Coushatta. In addition, although resulting in an identical protein, the variant should not be mistaken for Hb Lepore-Hollandia, which is produced at lower levels and causes a thalassemic phenotype. Hb Lepore Rochester-MN is controlled by the β-promoter and therefore is associated with approximately 40% variant and apparently normal CBC values in the two infants.
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Nuttall, Frank Q. "Effect of age on the percentage of hemoglobin A1c and the percentage of total glycohemoglobin in non-diabetic persons." Journal of Laboratory and Clinical Medicine 134, no. 5 (1999): 451–53. http://dx.doi.org/10.1016/s0022-2143(99)90165-8.
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Perincek, Gokhan, Sema Avcı, and Ilker Yılmam. "Comparison of complete blood counts of stable COPD patients at two different altitude in Turkey." Professional Medical Journal 26, no. 09 (2019): 1518–23. http://dx.doi.org/10.29309/tpmj/2019.26.09.3861.
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Introduction: The aim of this study was to evaluate how altitude difference affects complete blood count (CBC) in patients with stable Chronic Obstructive Pulmonary Disease (COPD). Study Design: Cross-sectional study. Setting: Department of Pulmonology, Kars Harakani State Hospital (Group 1) and Samsun Chest Diseases and Thoracic Surgery Hospital (Group 2), Turkey. Period: Six months i.e. from March to September 2018. Material and Methods: A total of 400 patients (200 female, 200 male) with stable COPD were included. For each group, 100 female and 100 male patients were randomly selected from hospitals. Age, BMI (kg/m2), comorbidity, smoking status, CBC were evaluated. Hemoglobin, hematocrit, WBC, MPV, platelet, lymphocyte count and percentage, platelet/lymphocyte rate (PLR), neutrophil count and percentage, neutrophil /lymphocyte rate (NLR), eosinophil count and percentage, PDW, PCT were recorded. Results: Patients living at high altitude were significantly older, had lower weight and had lower FEV1 levels. COPD stages of Group 1 patients were more severe (p<0.001). There were no moderate COPD patients in this group and the patients had fewer comorbidities (43%). Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were significantly higher in Group 1 (p<0.001). PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in Group 2 patients (p<0.001). Conclusion: Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were higher in patients living at high altitude. PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in patients living at low altitude.
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Zerari Aicha, Mahdi Djahida, Allaoua Sofia Amel, and Rouar Salim. "Effect of gender on hematological parameters in growing Ouled Djellal sheep of semi arid zones of Northeastern Algeria." South Asian Journal of Experimental Biology 11, no. 4 (2021): 407–17. http://dx.doi.org/10.38150/sajeb.11(4).p407-417.
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Ouled Djellal sheep is the most dominant breed in Algeria due to its adapta-tion to harsh steppe environment. Hematological parameters are good indi-cators of animal health, but their values are breed-specific, and they are affected by age and gender. Therefore, this study aimed to determine the hematological profile of healthy Ouled Djellal lambs and ewe lambs reared traditionally under semi-arid zones of Algeria during the growing peri-od. Blood samples were taken from twenty-four Ouled Djellal lambs (12 males, 12 females) at 42, 63, 84 and 105 days of age to evaluate the count of White Blood Cells, Lymphocyte, Monocyte, Granulocyte, Red Blood Cell and total Platelet, the percentage of Lymphocyte, Monocyte and Granulocyte, Hemoglobin concentration, Hematocrit, Mean Corpuscular Volume, Mean Corpuscular Hemoglobin and Mean Corpuscular Hemoglobin Concentration by usual known methods. Both male and female lambs did not show signifi-cant variations in mean values of White Blood Cells, Lymphocyte count, Red Blood Cells, Hemoglobin, Mean Corpuscular Hemoglobin concentration, per-centage of Monocyte, Monocyte count, Gran percentage and Granulocyte count from 42ͭ ͪ day to 105ͭ ͪ days. Mean values of percentage of Lymphocyte, Hematocrite in lambs, Mean Corpuscular Hemoglobin in ewe lambs, and Mean Corpuscular Volume, Platelets levels in both lambs and ewe lambs indicated also variations during this period of growth. Significant Pearson's correlations were found between some hematological parameters in Ouled Djellal lambs and/or ewe lambs. Therefore, these findings provide usual val-ues, which can be considered for assessing the physiological, nutritional and health status of these animals.
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Yusuf, J. A., Patmalia, S. Suharti, M. Baihaqi, and L. Khotijah. "Estrus Characteristics, Percentage of Gestation, Hematology Profile, and Blood Metabolites in Garut Ewes Fed Ration with Different Protein Levels." IOP Conference Series: Earth and Environmental Science 1484, no. 1 (2025): 012018. https://doi.org/10.1088/1755-1315/1484/1/012018.
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Abstract This research aimed to analyze the effect of different level crude protein (CP) rations on estrus characteristics, percentage of gestation, hematological profile, and blood metabolites of Garut ewes. This study used 20 Garut ewes (I1-I2) with an average body weight of 36.37 ± 4.04 kg and 4 Dorper male sheep. This study used a randomized block design (RBD) with 2 treatments and 5 groups. The treatments used were P0 = grass+commercial concentrate (60:40) with 11% CP and P1 = grass+standardized concentrate (60:40) with 14% CP. Variables measured were estrus characteristics, number of fetuses, percentage of gestation, hematology (erythrocytes, leukocytes, hemoglobin, hematocrit, and leukocyte differentiation), and blood metabolites (glucose, triglycerides, total protein, albumin, blood urea nitrogen (BUN) and cholesterol). Data were analyzed using an independent sample T-test. The results showed that the use of ration with protein level 14% significantly decreased (P<0.05) vulvar temperature, but tended to increase (P<0.1) vulvar mucus. Vulvar color and shape were relatively similar between treatments. Higher levels of CP significantly increased (P<0.05) hemoglobin, hematocrit, total protein, and albumin levels in gestation sheep. Feeding ration with 14% crude protein can increase the percentage of successful gestation from 70% to 90% and improve hemoglobin and hematocrit levels in Garut ewes.
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LEBEL, H., and M. C. LOTTRUP. "Is the Sedimentation Value to be Corrected for Variations of the Hemoglobin Percentage?" Acta Medica Scandinavica 80, no. 4-6 (2009): 550–65. http://dx.doi.org/10.1111/j.0954-6820.1933.tb10813.x.
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Yu, Binglan, Zunchang Liu, and Thomas Ming Swi Chang. "Polyhemoglobin with Different Percentage of Tetrameric Hemoglobin and Effects on Vasoactivity and Electrocardiogram." Artificial Cells, Blood Substitutes, and Biotechnology 34, no. 2 (2006): 159–73. http://dx.doi.org/10.1080/10731190600580223.
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Obaid, Dr Basma Jasims, and Dr Sarab Shakir Abbas. "The percentage of hemoglobin Bart’s among group of neonates in Al-Najaf City." International Journal of Paediatrics and Geriatrics 7, no. 1 (2024): 07–12. http://dx.doi.org/10.33545/26643685.2024.v7.i1a.215.
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Coulon, Basil, Gaetana Di Liberto, Orianne Wagner Ballon, et al. "Study of Dense Red Blood Cells in Children with Sickle Cell Disease." Blood 128, no. 22 (2016): 4870. http://dx.doi.org/10.1182/blood.v128.22.4870.4870.
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Abstract Many Sickle cell disease (SCD) manifestations begin at an early age and with wide inter-individual variability. High Density Red Blood Cells (DRBCs) are a specific feature of SCD, assessed with phthalate density distribution method. RBCs dehydration causes higher polymerisation of hemoglobin S and sickling, and their percentage is associated to chronic organ damage and hemolysis in adults. The spleen is one of the first altered organs, with considered complete asplenia around the age of five. We assessed the percentage of DRBCs (%DRBCs) in 50 children followed in the Créteil Paediatric Sickle Cell Referral Centre. Eligible patients had hemoglobin SS or Hemoglobin S-β0 thalassemia, without recent blood transfusion. Endpoints were the %DRBCs, its correlation with hemolytic parameters, with splenic function, with clinical manifestation. In this first prospective study in pediatric population, %DRBCs was associated with age, with particular low rate before the age of four. %DRBCs was significantly associated with enhanced haemolysis: higher total bilirubin, higher reticulocytes count, and lower hemoglobin. The results concerning LDH and ASAT were more questionable. A higher %DRBCs was associated with a lower hemoglobin F percentage. The percentage of Pitted cells, reflecting spleen function, was correlated with %DRBCs in a univariate analysis. There was no association between %DRBCs and vaso-occlusive symptoms, as expected. No statistical correlation has been found between intracranial velocity and %DRBCs. Among the five patients suffering from chronic complications related to hemolysis (kidney disease, priapism), 4 had high %DRBCs. Thus, DRBCs appearance seems to be related to the impairment of the spleen function. As in SCD adults, anemia and hemolytic markers are associated with high %DRBCs. Longitudinal analysis, with DRBC measurements before any treatment intensification, in a larger population, will be the key to evaluate the prognostic value of DRBCs for organ damage. Disclosures No relevant conflicts of interest to declare.
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Thirah, Azhole, and M. R. Gangadhar. "Anemia and Hemoglobin Level in Angamis Children of Kohima District, Nagaland." Indian Journal of Research in Anthropology 6, no. 2 (2020): 45–50. http://dx.doi.org/10.21088/ijra.2454.9118.6220.6.
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The present study has been undertaken to estimate the hemoglobin content with the aim to find out the different levels of hemoglobin content among the Angami children (between 6-10 years) of Jotsoma, Kohima district, Nagaland. A total of 100 blood samples was collected from the children of various houses in different areas of the Jostoma village, Kohima district, Nagaland. Major percentage of children were normal and few under the category of moderate and mild. The boys and girls can equally have grouped into the same state of hemoglobin concentration, but no single girl found to be anemic in the age group of 6 and 10 years. However, more number of boys were anemic than girls.
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Marigliano, Marco, Anna Casu, Suzanne Bertera, Massimo Trucco, and Rita Bottino. "Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation." Journal of Transplantation 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/965605.
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Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets. The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect the metabolic trends after diabetes induction and islet transplantation. Sera from 15 NHPs were analyzed. 9 NHPs were rendered diabetic with streptozotocin (STZ), and 3 of them received porcine islet transplants. Hemoglobin A1c (HbA1c) percentage was measured with an assay based on a latex immunoagglutination inhibition methodology. Whereas diabetes and its duration were associated with increasing HbA1c levels, postislet transplantation blood glucose normalization was paralleled by a decrease in the HbA1c percentage. Our data provide evidence that HbA1c is a useful tool to monitor glucose metabolism in NHPs.
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Farooq, Fouzia, Emily R. Smith, Qing Pan, et al. "Comparison of Masimo Total Hemoglobin SpHb® continuous non-invasive hemoglobin monitoring device with laboratory complete blood count measurement using venous sample: Protocol for an observational substudy of the Pregnancy Risk and Infant Surveillance and Measurement Alliance Maternal and Newborn Health (PRISMA MNH) study." Gates Open Research 7 (March 20, 2023): 50. http://dx.doi.org/10.12688/gatesopenres.14499.1.
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Background: The Masimo Total Hemoglobin SpHb® is a continuous and non-invasive handheld device to measure hemoglobin levels. Previous research has found that SpHb is able to accurately detect hemoglobin levels in adult patients with a similar degree of bias and standard deviation to point-of-care invasive method measurements. Generally, limited clinical evidence, lack of validation of Masimo at higher than and lower than hemoglobin threshold values, and scientific consensus supporting the use of Masimo for accurate hemoglobin testing for the diagnosis of anemia during pregnancy calls for further research. Methods and analysis: The proposed prospective cohort will be nested within the ongoing Pregnancy Risk and Infant Surveillance and Measurement Alliance (PRISMA) Maternal and Newborn Health (MNH) study. Three study sites (located in Zambia, Kenya, and Pakistan) will participate and collect hemoglobin data at five time points (<20 weeks, 20 weeks, 28 weeks, 36 weeks’ gestation, and six weeks postpartum). We will measure hemoglobin using a venous blood sample via hematology auto-analyzer complete blood count (gold standard) and the non-invasive device. The primary objective is to assess agreement between Masimo total hemoglobin and complete blood count and on a continuous scale using Intraclass Correlation Coefficient and Bland-Altman Analysis. The second objective is to assess agreement between the two measures on a binary scale using Positive Percentage Agreement and Negative Percentage Agreement, Cohen’s Kappa, and McNemar Test. On an ordinal scale, agreement will be measured using Weighted Cohen’s Kappa and Harrel’s Concordance Index. Lastly, we will assess factors that might affect the accuracy of Masimo total hemoglobin using linear mixed models. Conclusions: The primary aim of this study is to assess the validity of the non-invasive Masimo device compared to the gold standard method of invasive hemoglobin measurements during pregnancy and postpartum periods for the diagnosis of anemia.
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Farooq, Fouzia, Emily R. Smith, Qing Pan, et al. "Comparison of Masimo Total Hemoglobin SpHb® continuous non-invasive hemoglobin monitoring device with laboratory complete blood count measurement using venous sample: Protocol for an observational substudy of the Pregnancy Risk and Infant Surveillance and Measurement Alliance Maternal and Newborn Health (PRISMA MNH) study." Gates Open Research 7 (February 5, 2024): 50. http://dx.doi.org/10.12688/gatesopenres.14499.2.
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Background The Masimo Total Hemoglobin SpHb® is a continuous and non-invasive handheld device to measure hemoglobin levels. Previous research has found that SpHb is able to accurately detect hemoglobin levels in adult patients with a similar degree of bias and standard deviation to point-of-care invasive method measurements. Generally, limited clinical evidence, lack of validation of Masimo at higher than and lower than hemoglobin threshold values, and scientific consensus supporting the use of Masimo for accurate hemoglobin testing for the diagnosis of anemia during pregnancy calls for further research. Methods and analysis The proposed prospective cohort will be nested within the ongoing Pregnancy Risk and Infant Surveillance and Measurement Alliance (PRISMA) Maternal and Newborn Health (MNH) study. Three study sites (located in Zambia, Kenya, and Pakistan) will participate and collect hemoglobin data at five time points (<20 weeks, 20 weeks, 28 weeks, 36 weeks’ gestation, and six weeks postpartum). We will measure hemoglobin using a venous blood sample via hematology auto-analyzer complete blood count (gold standard) and the non-invasive device. The primary objective is to assess agreement between Masimo total hemoglobin and complete blood count and on a continuous scale using Intraclass Correlation Coefficient and Bland-Altman Analysis. The second objective is to assess agreement between the two measures on a binary scale using Positive Percentage Agreement and Negative Percentage Agreement, Cohen’s Kappa, and McNemar Test. On an ordinal scale, agreement will be measured using Weighted Cohen’s Kappa and Harrel’s Concordance Index. Lastly, we will assess factors that might affect the accuracy of Masimo total hemoglobin using linear mixed models. Conclusions The primary aim of this study is to assess the validity of the non-invasive Masimo device compared to the gold standard method of invasive hemoglobin measurements during pregnancy and postpartum periods for the diagnosis of anemia.
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WONG, PEERAPON. "HEMOGLOBIN ANALYSIS IN THE FIRST YEAR OF LIFE." Mediterranean Journal of Hematology and Infectious Diseases 8 (February 12, 2016): 2016012. http://dx.doi.org/10.4084/mjhid.2016.012.
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Background and Objectives: In newborns and infants during their first year of life, there is a dynamic change in the fraction of hemoglobin (Hb). To apply Hb analysis as a phenotypic diagnosis of thalassemia in newborns and infants, we need normal values of each Hb fraction for reference. Methods: Seventeen cord bloods from normal deliveries were collected for analysis. One hundred and thirty seven infants from the pediatric outpatient clinic were recruited and were categorized by their ages into a series of short periods (month+2 weeks). Both alpha and beta thalassemia carriers detected were excluded. Samples with an Hb level less than 10.0 g/dL were also excluded. The proportion of Hb A (a2b2), A2 (a2d2), and F (a2g2) was obtained from high performance liquid chromatography and analyzed according to its categorized periods. Results: There were 90 (58.4%) specimens left for evaluation. The percentage of Hb A, A2, and F gradually changed with increasing age. The percentage of Hb A was 21.14+7.04% (mean+SD) in cord blood and increased substantially to 83.38+1.31% at the sixth month. The level was sustained thereafter. The incremental pattern of Hb A2 was similar to Hb A. The value was 0.32+0.19% at the beginning and reached a plateau with 2.78+0.25% at the sixth month. The percentage of Hb F started at 78.39+7.59% in cord blood and decreased rapidly in the first 6 months. Conclusions: The data possibly can be applied as quick guidance for interpretation of Hb analysis in newborns and infants during their first year of life.
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Knapp, Esther E., Deepa Manwani, Abdullah Kutlar, Hillel W. Cohen, and Richard G. Ghalie. "Intra-Patient Variability in Fetal Hemoglobin Measurements over Time in Sickle Cell Disease Patients Not on Fetal Hemoglobin Inducing Agents." Blood 124, no. 21 (2014): 4096. http://dx.doi.org/10.1182/blood.v124.21.4096.4096.
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Abstract Introduction: We previously reported results of the placebo-controlled phase II study of the short-chain fatty acid derivative 2,2-dimethylbutyrate in inducing fetal hemoglobin (Hb F) in 76 patients with sickle cell disease (SCD). The primary endpoint was a comparison of Hb F levels in the treatment versus the placebo arms. Week 24 interim analyses revealed no statistically significant difference in change in Hb F levels between the 2 groups. We examined the placebo arm in order to assess untreated, intra-patient variability of Hb F%. Methods: Only Hb F values performed by HPLC at the central reference laboratory (Georgia Health Science University) were included. Any Hb F values determined within a 3 month period after a blood transfusion were excluded. Baseline and at least one subsequent Hb F levels were available in 37 of the 38 patients randomized to the placebo arm, which were included in the analysis. Serial determinations were performed at 4 week intervals, resulting in a total of 348 determinations and a median of 9 values per patient (range 2 - 15). Mean and standard deviation of repeat measures of Hb F% in each individual patient were calculated. A mean ± SD of the individual coefficients of variation (SD/mean of repeat measures for each individual) was calculated. Peak-to-trough (maximum - minimum) ranges of repeated measures were also calculated per individual and quartiles for the group determined. To assess the potential for regression to the mean from baseline, we calculated the median peak-to-trough within quartiles of baseline Hb F. We assessed the difference between maximum and minimum values as a percentage of the maximum or percentage deviation from personal best Hb F%, and finally we examined the association of baseline Hb F, age, gender and race with the degree of variability. Results: Patient median (range) age was 25.9 years (12 – 46), 24 (63%) were female, the genotype was Hb SS in 30 patients (79%) and Hb S/β0 thalassemia in 8 (21%), and no patient was treated with hydroxycarbamide at enrollment. Median (range) values of Hb F percentage at baseline were 7.5% (0.5 – 23.4). The mean coefficient of variation of all Hb F values was 13%, with a peak to trough median (range) of 1.8 (0.1 - 9.8). The mean percentage Hb F % variability over time was 31.8% (S.D +/- 18) and median (range) value of 26.1 (7.2-80) with quartiles depicted in Table 1. Baseline Hb F% negatively correlated with the percentage variability and this association was highly statistically significant (Spearman rho –0.34, p = 0.04). Table I: Intra-patient variability in successive Hb F% levels expressed as a percentage deviation from peak values Quartiles Range of Values (% difference between maximum and minimum HbF) n < 25th 7.2-20.6 9 25-49 20.7-26.1 10 50-74 26.2- 39.2 9 75-100 39.3-80 9 Discussion: There is substantial Hb F variability among patients not on any Hb F inducer. This variability has not been previously reported and influences both the standard deviation and standard error, and would likely lower the statistical power of any comparative analysis in a clinical trial. Thus, sample sizes should be larger to be able to detect a sizeable difference between experimental and control groups. Variability among treated patients is harder to assess because it is difficult to separate out intrinsic variability from treatment effects and medication adherence. We have not attempted to assess the intra-patient variability in Hb F among patients given study drug in this study. However, it seems reasonable to assume that the variability seen in untreated patients would also be seen, to some degree, within treated patients. Thus, using Hb F percentage alone as a measure of medication compliance (with a Hb F inducing agent) may not be reliable. Possible explanations for this variability over time include artifacts of laboratory technique, increased hemolysis with increased erythropoietic drive, worsening renal function (and subsequent decrease in erythropoietin production), and bone marrow infarction, leading to disrupted hematopoiesis. Disclosures Kutlar: NIH/NIMHD: Research Funding. Ghalie:HemaQuest Pharmaceuticals, Inc.: Employment.
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Tilome, Puput, Torajasa Achmar, and Yolan Dunggio. "OVERVIEW OF HEMOGLOBIN LEVELS IN PATIENTS WITH DIABETES MELLITUS Renal Complications in TOTO KABILA Hospital, 2020." Journal of Health, Technology and Science (JHTS) 2, no. 3 (2022): 1–9. http://dx.doi.org/10.47918/jhts.v2i3.198.
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In 2018 the number of sufferersDiabetes mellitusin Bone Bolango district ranks sixth in Gorontalo Province. Data from Toto Kabila Hospital in 2020, as many as 24 patients. In some cases the disease that can cause complications in patients with diabetes mellitus is kidney failure. The decrease in hemoglobin levels in patients with kidney disorders is caused by decreased levels of erythropoietin which stimulates the bone marrow to produce red blood cells.
 The aim of the study was to describe the hemoglobin levels in patients with diabetes mellitus with kidney complications.
 This research design using quantitative descriptive. Conducted at Toto Kabila Hospital with a total sample of 24 patients with diabetes mellitus with kidney complications. The sampling technique was total sampling. Using the Univariate data analysis technique then the results are presented in tabular form.
 Based on the results of the study of 24 samples, it was found that the results of normal hemoglobin levels were 9 samples with a percentage (37.5%) while patients who had abnormal hemoglobin levels were 15 samples with a percentage (62.5%).
 
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Restu, Korbaffo Anita, Novita Ana Anggraini, and Nur Yeny Hidajaturrokmah. "The Analysis of the Roasting Tradition (Se’i/Nu), Maternal Hemoglobin Level and the Uterine Involution Process among Puerperal Women." Jurnal Ners 15, no. 1Sp (2020): 462–65. http://dx.doi.org/10.20473/jn.v15i1sp.20509.
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Se'i/nu is one of the traditions of the local community on the island of Timor. The research objective was to prove the relationship between the roasting tradition (se'i/nu) with the hemoglobin level and the process of uterine involution in postpartum women. The research design was analytical with an observational approach. The sample consisted of 42 respondents obtained through total sampling. The independent variable was the roasting tradition (se’i/nu) and the dependent variables were hemoglobin level and maternal uterine involution. The method used to measure the roasting tradition (se’i/nu) was an observation sheet. To measure the hemoglobin level, we used a laboratory check and to measure uterine involution, we conducted a physical examination and used an observation sheet. The results showed that the largest percentage of hemoglobin levels in postpartum mothers was among those that did the roasting tradition (se'i/nu) with an abnormal hemoglobin level of 66.66% (22 people). The puerperal women who did the tradition of roasting (se'i/nu) obtained high uterine fundus and the abnormal mothers made up the largest percentage of 69.70% (23 people). There was a correlation between the roasting tradition (se'i/nu) and maternal hemoglobin level (p=0.025) and there was also a correlation between the roasting tradition (se'i/ nu) with the process of maternal uterine involution (0.00). The conclusion is that there is a prolonged uterine involution process and that the low hemoglobin levels in the puerperium may be due to exposure to chemical susceptibility as a result of inhaling polluted air due to the se'i/nu process.
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Dias, Pedro Alexandre, Sofia Caldeira-Dantas, Maria Miguel Carvalho, Ana Marreiros, Ana Paula Fontes, and João Paulo Sousa. "Blood management in total knee arthroplasty: an exploratory study regarding the use of drain and tranexamic acid in two types of instrumentation." International Journal of Research in Orthopaedics 10, no. 4 (2024): 711–16. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20241694.
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Background: This study investigates how presence or absence of drain or tranexamic acid (TXA) in 2 different types of instrumentation with invasion/sparing femoral canal affects hemoglobin drop after total knee arthroplasty (TKA). Methods: This was a retrospective observational study that included 736 individuals divided in five groups, regarding conventional instrumentation (CI) or patient specific instrumentation (PSI), presence or absence of drain and TXA. Mean percentage of hemoglobin drop after the first postoperative day was compared for each group. Results: Patients submitted to CI using drain and no TXA revealed the highest value (21,3%±9,1; p<0,001). Groups who received TXA and drain was not used, presented the lowest blood loss. Moreover, with the introduction of TXA PSI lost its advantage over CI. Conclusions: TKA using CI, without drain and with TXA administration showed better results, reducing mean percentage of hemoglobin drop after surgery.
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Ogbonna, Ogbodo Sylvester, Chukwurah Ejike Felix, Eze Chukwuka Wencelaus, Eze Richard Ikechukwu, and Udengwu Nonyerem Lilian. "Fetal Hemoglobin Levels as Indicator of Frequency and Duration of Blood Donation." International Journal of Scientific Research and Management 9, no. 06 (2021): 389–94. http://dx.doi.org/10.18535/ijsrm/v9i06.mp03.
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Hemoglobin F is normal hemoglobin seen in minute amount in adults. Increase in its level in adults is an indication of erythropoietic stress, which in most cases is linked to hemoglobinopathy. This study was undertaken to assess if physiological erythropoietic stress as seen in commercial blood donation, can increase it and thus be used as an indicator of frequency and duration of blood donation. The study involved 152 subjects including 88 commercial blood donors and 64 controls. Hemoglobin F was expressed as percentage concentration of the total hemoglobin. Results showed that hemoglobin F significantly increased in commercial blood donors when compared with the controls. There was also strong positive correlation between hemoglobin F level and age of the donors which was not the case with the controls. The results indicate that hemoglobin F level can be used as an indicator of the frequency and duration of blood donation. Though blood donation has some health benefits, the disadvantages of frequent donation outweigh these benefits and should be discouraged.
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Wijaya, Christian, Vincent Aditya Budi Hartono, Angel Sharon Suros, Farell Christian Gunaidi, and Edwin Destra. "Penapisan Hematokrit dan Hemoglobin pada Laki-Laki dan Perempuan Usia Produktif di SMA Kalam Kudus II, Jakarta." Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri 3, no. 2 (2024): 60–68. http://dx.doi.org/10.58192/sejahtera.v3i2.2124.
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Hemoglobin and hematocrit are important parameters in assessing anemia and other blood diseases. Hemoglobin transports oxygen from the lungs to the rest of the body, while hematocrit reflects the density of red blood cells in the blood. This community service activity was carried out at Kalam Kudus II High School, Duri Kosambi Village, Jakarta, involving 68 men and women of productive age. Screening activities are carried out by measuring hemoglobin and hematocrit levels using the For-A brand Point Of Care Testing (POCT) tool. The majority of respondents had normal hemoglobin levels (68.9%), while a small percentage experienced mild anemia (21.6%) and moderate anemia (9.5%). The average hemoglobin level was 13.28 g/dL and hematocrit 38.66%. The 18-35 year age group has the highest hemoglobin and hematocrit levels, while the 51-64 year age group has the lowest. Lifestyle factors, nutrition, genetics, and chronic medical conditions influence hemoglobin and hematocrit levels. Regular monitoring is important in detecting and managing anemia and improving public health.
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Liu, N., A. H. Wu, and S. S. Wong. "Improved quantitative Apt test for detecting fetal hemoglobin in bloody stools of newborns." Clinical Chemistry 39, no. 11 (1993): 2326–29. http://dx.doi.org/10.1093/clinchem/39.11.2326.
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Abstract We devised an improved spectrophotometric method, based on the differential susceptibility of various hemoglobins to alkaline denaturation, to measure the percentage of fetal hemoglobin (HbF) in bloody meconium so as to determine the source of the blood. The oxyhemoglobin of a sample was spectrophotometrically scanned from 450 to 650 nm before and after the addition of sodium hydroxide. With Allen baseline correction, the ratio of absorbance at 576 nm was linearly proportional to the percentage of HbF in the specimen as described by the equation: ratio = 0.01 (%HbF) + 0.0045 (r = 0.9971, Sy/x = 0.047). Preliminary studies on samples containing 10% or 80% HbF revealed that the method was fairly precise. The accuracy of this test was verified by comparing the results (y) with those obtained by radial immunodiffusion (x): y = 0.997x + 2.93 (r = 0.91). This preliminary study demonstrates that the modified test is simple, fast, and free from bilirubin interference. It should be useful for the diagnosis of gastrointestinal bleeding of the newborn on a stat basis.
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Rożyñski, Maciej, Krystyna Demska-Zakęś, and Dorota Fopp-Bayat. "Hematological and blood gas profiles of triploid Siberian sturgeon (Acipenser baerii Brandt)." Archives of Polish Fisheries 23, no. 4 (2015): 197–203. http://dx.doi.org/10.1515/aopf-2015-0022.
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Abstract The aim of the study was to determine the impact of triploidization on hematological and blood gas parameters in Siberian sturgeon, Acipenser baerii Brandt. The study material was comprised of juvenile Siberian sturgeon specimens with total body lengths of 22.3 ± 2.9 cm and mean body weights of 75.3 ± 40.7 g. Triploidization was confirmed to result in significant changes in the hematological profile of Siberian sturgeon. In comparison to the diploid group, the fish with higher levels of ploidy exhibited lower erythrocyte counts, increased hemoglobin concentration, and increased values of mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. A significant decrease in the percentage share of lymphocytes and an increase in the percentage share of granulocytes in the peripheral blood were also observed, which indicate disturbances in the immune response (particularly in the adaptive immune system) and greater susceptibility to stress. Triploidization did not, however, cause significant differences in the blood gas profile.
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Nathan, David M., Amanda Griffin, Francesca M. Perez, Erica Basque, Lily Do, and Barbara Steiner. "Accuracy of a Point-of-Care Hemoglobin A1c Assay." Journal of Diabetes Science and Technology 13, no. 6 (2019): 1149–53. http://dx.doi.org/10.1177/1932296819836101.
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Point-of-care test (POCT) HbA1c assays provide rapidly available results for clinical decision-making. Accuracy and precision must be established. Venous blood samples from 300 patients were assayed for HbA1c by a laboratory technician (“laboratory assessment”) with the POCT Alere Afinion™ assay and a laboratory (Premier AffinityTM) assay. POCT results from 402 patients’ fingerstick samples assayed by nine nontechnician staff (“clinical assessment”) were compared with the laboratory assay. The laboratory assessment showed tight correlation ( r2= .977, P < .001) between the assays. Mean absolute and relative differences were 0.01 percentage points and 2.1%, respectively. CVs for the POCT and laboratory assays were <2% and <1%, respectively. The clinical assessment also showed a tight correlation between the assays ( r2= .978, P < .001), with mean absolute and relative differences of 0.2 percentage points and 3.41%, respectively. CV for the POCT assay was <2%. The POCT performed acceptably compared to the laboratory assay under realistic clinical conditions.
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Yuan, Xiaojuan, Wei Yu, Ronghua Wu, Longkun Li, and Fan He. "A Prospective Comparison of Three Strategies for Evaluating Blood Loss in Transurethral Resection of the Prostate." BioMed Research International 2021 (April 7, 2021): 1–6. http://dx.doi.org/10.1155/2021/8875380.
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Objective. The aim of the current investigation is to develop a new strategy for evaluating blood loss in the process of transurethral resection of the prostate (TURP). Methods. 318 patients diagnosed with benign prostatic hyperplasia (BPH) that need TURP were enrolled in this study. Hospitalization information including age, height, weight, surgery time, prostate volume, hemoglobin (Hb) concentration, hematocrit (HCT) percentage, and red blood cell count (RBC) was evaluated for each patient. All statistical analysis drawing were conducted using R software. Results. Three methods were employed for calculating blood loss in TURP. Results from a new method display 0 missing value and got higher confidence (0 of 318, Poisson distribution, P < 0.001 ) compared with blood loss calculated with hemoglobin concentration (20.44%) and hematocrit percentage (19.18%). Also, the new method demonstrated narrow range (0.03~270.03 ml) and approximate normal distribution compared with blood loss calculated with hemoglobin concentration and hematocrit percentage. More importantly, the new method explained positive correlation with prostate volume ( R 2 = 0.138 , P < 0.001 ) and also surgery lasting time ( R 2 = 0.193 , P < 0.001 ). Conclusion. Methods developed for calculating blood loss in TURP in the current study displayed more accurate and reasonable evaluation of bleeding, which can guide the transfusion blood for patients.
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Kisadere, Ihsan, Mehmet F. Aydin, and Hasan H. Dönmez. "The influence of chitosan oligosaccharide on some hematological parameters in rats exposed to cadmium." Veterinarski arhiv 92, no. 1 (2022): 87–95. http://dx.doi.org/10.24099/vet.arhiv.1319.
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The aim of the study was to investigate the effects of chitosan oligosaccharide (COS) on some hematological parameters, and define the percentage of alpha-naphthyl acetate esterase (ANAE) positive lymphocytes in rats that had been exposed to cadmium (Cd). Thirty-two (n = 32) male Wistar albino rats were randomly divided into four groups as the control (C), chitosan oligosaccharide (COS), cadmium (Cd), and Cd + COS (CdCOS) groups. Blood samples were collected to assess erythrocytes (RBC), leukocytes (WBC), hemoglobin levels (HGB), hematocrit values (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), platelets (PLT), and alpha-naphthyl acetate esterase (ANAE) positive lymphocytes. The number of WBCs significantly increased in the Cd group compared to the C, CdCOS, and COS groups (P<0.05). Although the lymphocyte count decreased significantly in the Cd group (P<0.05), it was ameliorated by COS treatment in the CdCOS group compared to the Cd group (P<0.05). Also, the percentage of peripheral blood ANAE positive lymphocytes decreased significantly in the CdCOS and Cd groups (P<0.05). COS exhibits a partially protective effect on some hematological characteristics, apart from the percentage of ANAE positive lymphocyte in cases of chronic Cd exposure.
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Zuzak, Karel J., Mark T. Gladwin, Richard O. Cannon, and Ira W. Levin. "Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 3 (2003): H1183—H1189. http://dx.doi.org/10.1152/ajpheart.00243.2003.
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Sickle cell disease is characterized by microvascular occlusion and hemolytic anemia, factors that impair tissue oxygen delivery. We use visible reflectance hyperspectral imaging to quantitate skin tissue hemoglobin oxygen saturation (HbO2) and to determine whether changes in blood flow during nitric oxide (NO) stimulation or gas administration (therapies proposed for this disease) improve skin tissue oxygen saturation in five patients with sickle cell disease. Compared with six healthy African-American subjects, sickle cell patients exhibited higher forearm blood flows (7.4 ± 1.8 vs. 3.2 ± 0.4 ml·min–1·100 ml tissue–1, P = 0.037) but significantly reduced percentages of skin HbO2 (61.0 ± 0.2 vs. 77.5 ± 0.2%, P < 0.001). Administration of acetylcholine to patients increased blood flow by 15.1 ± 3.8 ml·min–1·100 ml tissue–1 and the percentage of skin HbO2 by 4.1 ± 0.3% ( P = 0.02, P < 0.001, respectively, from baseline values). Sodium nitroprusside, a direct NO donor, increased blood flow by 3.9 ± 1.1 ml/min and the percentage of skin HbO2 by 2.9 ± 0.3% ( P = 0.02, P < 0.001, respectively). NO inhalation had no effect on forearm blood flow, yet increased the percentage of skin HbO2 by 2.3 ± 0.3% ( P < 0.001). Percentages of skin HbO2 were exponentially related to blood flow ( R = 0.97, P < 0.001), indicating a limit to skin tissue oxygen saturation at high blood flows. Thus, for acetylcholine infusion leading to blood flows sevenfold greater than those of healthy resting African-American subjects, patients still exhibited lower percentages of skin HbO2 (65.2 ± 0.2 vs. 77.5 ± 0.2%, P < 0.001). Visible reflectance hyperspectral imaging demonstrates that either the stimulation or the administration of NO pharmacologically or by gas inhalation improves, but does not normalize, skin tissue oxygen saturation in patients with sickle cell disease.
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Malczewska-Lenczowska, Jadwiga, Olga Surała, Joanna Orysiak, Dariusz Turowski, Beata Szczepańska, and Paweł Tomaszewski. "Utility of Novel Hypochromia and Microcythemia Markers in Classifying Hematological and Iron Status in Male Athletes." Nutrients 11, no. 11 (2019): 2767. http://dx.doi.org/10.3390/nu11112767.
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In athletes, no reliable indices exist for an unambiguous evaluation of hematological and iron status. Therefore, the utility of some new red blood cell (RBC) parameters was explored in 931 elite male athletes aged 13–35 years. To diagnose iron status, the values of ferritin and soluble transferrin receptor (sTfR), total iron binding capacity (TIBC), and basic blood morphology were determined in blood. The new hematological markers included among others: mean cellular hemoglobin content in reticulocytes (CHr), percentage of erythrocytes (HYPOm) and reticulocytes (HYPOr) with decreased cellular hemoglobin concentration, percentage of erythrocytes (LowCHm) and reticulocytes (LowCHr) with decreased cellular hemoglobin content, mean volume of reticulocytes (MCVr), and percentage of erythrocytes with decreased volume (MICROm). Despite adverse changes in reticulocyte hypochromia indices (CHr, LowCHr, HYPOr; p < 0.001) in the iron depletion state, the area under the receiver operating characteristic curve (AUC-ROC) values calculated for them were relatively low (0.539–0.722). In iron-deficient erythropoiesis (IDE), unfavorable changes additionally concern microcythemia indices in both reticulocytes and erythrocytes (MCVr, MCV, MICROm, and red cell volume distribution width—RDW), with especially high values of AUC-ROC (0.947–0.970) for LowCHm, LowCHr, and CHr. Dilutional sports anemia was observed in 6.1% of athletes. In this subgroup, only hemoglobin concentration (Hb), hematocrit (Hct), and RBC (all dependent on blood volume) were significantly lower than in the normal group. In conclusion, the diagnostic utility of the new hematology indices was not satisfactory for the detection of an iron depletion state in athletes. However, these new indices present high accuracy in the detection of IDE and sports anemia conditions.
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Mustafa, Ibrahim, and Tameem Ali Qaid Hadwan. "Hemoglobin Oxidation in Stored Blood Accelerates Hemolysis and Oxidative Injury to Red Blood Cells." Journal of Laboratory Physicians 12, no. 04 (2020): 244–49. http://dx.doi.org/10.1055/s-0040-1721156.
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Abstract Introduction Maintaining blood supply is a challenge in blood banks. Red blood cells (RBCs) stored at 4°C experience issues of biochemical changes due to metabolism of cells, leading to changes collectively referred to as “storage lesions.” Oxidation of the red cell membrane, leading to lysis, contributes to these storage lesions. Methods Blood bags with CPD-SAGM stored at 4°C for 28 days were withdrawn aseptically on days 1, 14, and 28. Hematology analyzer was used to investigate RBC indices. Hemoglobin oxidation was studied through spectrophotometric scan of spectral change. RBC lysis was studied with the help of Drabkin's assay, and morphological changes were observed by light and scan electron microscopy. Results RBCs show progressive changes in morphology echinocytes and spherocytes on day 28. There was 0.85% RBC lysis, an approximately 20% decrease in percentage oxyhemoglobin, and a 14% increase in methemoglobin formation, which shows hemoglobin oxidation on day 28. Conclusions Oxidative damage to RBC, with an increase in storage time was observed in the present study. The observed morphological changes to RBC during the course of increased time shows that there is progressive damage to RBC membrane and a decrease in hemoglobin concentration; percentage RBC lysis is probably due to free hemoglobin and iron.
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Miller, BA, SP Perrine, A. Bernstein, et al. "Influence of steel factor on hemoglobin synthesis in sickle cell disease." Blood 79, no. 7 (1992): 1861–68. http://dx.doi.org/10.1182/blood.v79.7.1861.1861.
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Abstract A new hematopoietic growth factor (Steel factor) has been identified which stimulates erythroid proliferation both in vitro and in vivo. We evaluated the influence of recombinant Steel factor on hemoglobin synthesis in peripheral blood (PB) BFU-E-derived cells from normal donors by radioimmunoassay (RIA) and compared it with stimulation with GM-CSF and interleukin-3 (IL-3). Only Steel factor stimulated a significant increase in BFU-E-derived colony size and a significant increase in fetal hemoglobin (HbF) in BFU-E-derived erythroblasts from 0.49% +/- 0.27% to 6.33% +/- 1.11% in serum-deprived media and from 1.88% +/- 0.24% to 11.17% +/- 0.91% in serum. To determine whether this influence on hemoglobinization also occurred in sickle cell disease, we studied 13 patients with sickle cell disease. In serum-deprived conditions, there was a significant increase in the number and size of BFU-E-derived colonies with Steel factor that was dose-dependent. In addition, the proportion of HbF in progenitor-derived cells increased by 66% from 4.1% +/- 0.6% to 6.8% +/- 1.2% with Steel factor. In serum- containing conditions studied in 12 patients, the increase in percentage of HbF was even greater, from 10.7% +/- 0.9% in control cultures to 22.5% +/- 2.6% with Steel factor. These increases in percentage of HbF were significant and dose-dependent. An increase in percentage of HbF was observed in erythroblasts harvested on day 11, 14, and 18 of culture. A decrease in mean picograms of total Hb per cell after coculture with Steel factor was noted, suggesting that growth kinetics influenced complete hemoglobinization. In serum- deprived conditions, picograms of HbF per cell was not affected by Steel factor, and in serum-containing conditions that augment in vitro HbF production it was enhanced. Thus, Steel factor stimulated a significant increase in percentage of HbF in erythroid cells from normal donors and patients with SCA in vitro.
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Miller, BA, SP Perrine, A. Bernstein, et al. "Influence of steel factor on hemoglobin synthesis in sickle cell disease." Blood 79, no. 7 (1992): 1861–68. http://dx.doi.org/10.1182/blood.v79.7.1861.bloodjournal7971861.
Full textAbstract:
A new hematopoietic growth factor (Steel factor) has been identified which stimulates erythroid proliferation both in vitro and in vivo. We evaluated the influence of recombinant Steel factor on hemoglobin synthesis in peripheral blood (PB) BFU-E-derived cells from normal donors by radioimmunoassay (RIA) and compared it with stimulation with GM-CSF and interleukin-3 (IL-3). Only Steel factor stimulated a significant increase in BFU-E-derived colony size and a significant increase in fetal hemoglobin (HbF) in BFU-E-derived erythroblasts from 0.49% +/- 0.27% to 6.33% +/- 1.11% in serum-deprived media and from 1.88% +/- 0.24% to 11.17% +/- 0.91% in serum. To determine whether this influence on hemoglobinization also occurred in sickle cell disease, we studied 13 patients with sickle cell disease. In serum-deprived conditions, there was a significant increase in the number and size of BFU-E-derived colonies with Steel factor that was dose-dependent. In addition, the proportion of HbF in progenitor-derived cells increased by 66% from 4.1% +/- 0.6% to 6.8% +/- 1.2% with Steel factor. In serum- containing conditions studied in 12 patients, the increase in percentage of HbF was even greater, from 10.7% +/- 0.9% in control cultures to 22.5% +/- 2.6% with Steel factor. These increases in percentage of HbF were significant and dose-dependent. An increase in percentage of HbF was observed in erythroblasts harvested on day 11, 14, and 18 of culture. A decrease in mean picograms of total Hb per cell after coculture with Steel factor was noted, suggesting that growth kinetics influenced complete hemoglobinization. In serum- deprived conditions, picograms of HbF per cell was not affected by Steel factor, and in serum-containing conditions that augment in vitro HbF production it was enhanced. Thus, Steel factor stimulated a significant increase in percentage of HbF in erythroid cells from normal donors and patients with SCA in vitro.
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Richter, Nadine A. "Percentage of glycosylated hemoglobin and serum concentration of glucose in the blood of Japanese macaques and in three exotic ruminant species." American Journal of Veterinary Research 47, no. 8 (1986): 1783–84. https://doi.org/10.2460/ajvr.1986.47.08.1783.
Full textAbstract:
SUMMARY Serum glucose concentrations and percentages of glycosylated hemoglobin (GHb) were determined m 16 Japanese macaques and in 19 exotic ruminants (4 markhor, 5 mouflon, 10 aoudad). Mean (± sd) serum glucose concentration and GHb percentage in the Japanese macaques were 73 ± 21.8 mg/dl and 4.7 ± 0.82%, respectively. Serum glucose concentration was considered within the normal range for this species. The mean GHb percentage was within the normal range for man, indicating that GHb may be a valid indicator of long-term mean serum glucose concentration in the Japanese macaque. Mean serum glucose concentrations in the markhor, mouflon, and aoudad were 110 ± 23.2, 111.4 ± 37.1, and 132.5 ± 38.5 mg/dl, respectively, and were considered within the normal ranges for these species. Mean GHb percentages for each of the 3 ruminant species were 0.425, 1.04, and 0.74%, respectively, which may have been below the range of accuracy for the testing procedure used, probably due to low erythrocyte permeability to glucose rather than to a shortened erythrocyte lifespan.
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Lande, WM, DL Andrews, MR Clark, et al. "The incidence of painful crisis in homozygous sickle cell disease: correlation with red cell deformability." Blood 72, no. 6 (1988): 2056–59. http://dx.doi.org/10.1182/blood.v72.6.2056.2056.
Full textAbstract:
Abstract To determine whether the vasoocclusive severity of homozygous sickle cell (SS) disease is influenced by cellular dehydration, we correlated the incidence of painful crisis with steady-state measurements of red cell hydration. Sixteen children with SS disease were followed for 3.3 to 8 years (mean, 6.8 years), and a single crisis rate was calculated for each patient. At the time of well visits, cellular hydration was assessed by measuring cell deformability, the percentage of red cells with a density greater than or equal to 1.1056 g/mL, and the percentage of irreversibly sickled cells (ISC). The incidence of painful crisis showed a strong positive correlation with Omax, a deformability measurement reflecting cellular hydration (r = .84, P less than .002), and with hemoglobin concentration (r = .59, P = .04). That is, higher crisis rates were observed in patients with less dehydrated, more deformable red cells and also in patients with higher hemoglobin concentrations. Furthermore, cell deformability and hemoglobin concentration were independent predictors of the incidence of painful crisis, which is consistent with separate effects of these two red cells parameters on vasoocclusive severity.
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Lande, WM, DL Andrews, MR Clark, et al. "The incidence of painful crisis in homozygous sickle cell disease: correlation with red cell deformability." Blood 72, no. 6 (1988): 2056–59. http://dx.doi.org/10.1182/blood.v72.6.2056.bloodjournal7262056.
Full textAbstract:
To determine whether the vasoocclusive severity of homozygous sickle cell (SS) disease is influenced by cellular dehydration, we correlated the incidence of painful crisis with steady-state measurements of red cell hydration. Sixteen children with SS disease were followed for 3.3 to 8 years (mean, 6.8 years), and a single crisis rate was calculated for each patient. At the time of well visits, cellular hydration was assessed by measuring cell deformability, the percentage of red cells with a density greater than or equal to 1.1056 g/mL, and the percentage of irreversibly sickled cells (ISC). The incidence of painful crisis showed a strong positive correlation with Omax, a deformability measurement reflecting cellular hydration (r = .84, P less than .002), and with hemoglobin concentration (r = .59, P = .04). That is, higher crisis rates were observed in patients with less dehydrated, more deformable red cells and also in patients with higher hemoglobin concentrations. Furthermore, cell deformability and hemoglobin concentration were independent predictors of the incidence of painful crisis, which is consistent with separate effects of these two red cells parameters on vasoocclusive severity.
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Fiechtner, M., J. Ramp, B. England, et al. "Affinity Binding Assay of Glycohemoglobin by Two-Dimensional Centrifugation Referenced to Hemoglobin A1C." Clinical Chemistry 38, no. 12 (1992): 2372–79. http://dx.doi.org/10.1093/clinchem/38.12.2372.
Full textAbstract:
Abstract We describe an automated assay of glycohemoglobin performed with the Abbott Vision analyzer. The assay is based on batch affinity-extraction with 3-aminophenylboronic acid-derivatized agarose beads. Reagents are packaged in a disposable test pack. Whole-blood specimens are hemolyzed with saponin within a glass capillary tube inserted into the test pack. The sample is automatically diluted with, mixed with, and separated from the solid-phase reagent. Bichromatic absorbance readings are used to calculate the percentage of hemoglobin bound. Based on the linear correlation between affinity-measured glycohemoglobin and HPLC-measured hemoglobin A1c, the percentage of hemoglobin bound is converted to a "standardized %HbA1c" result by use of regression parameters stored during a calibration run. The combination of affinity methodology with standardization by reference to HPLC produces values directly comparable with those obtained by methods specific for HbA1c. The method produces 10 results within 15 min. The assay operates with CVs &lt; 5%, and the results correlate highly with those by ion-exchange and affinity minicolumn methods, and by ion-exchange HPLC.
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Mirzakhalilov, Sanjar. "PRINCIPLES OF INTELLIGENT MONITORING OF SATURATION OF ATHLETES DURING TRAINING AND COMPETITION." Research and implementation 1, no. 1 (2023): 37–43. https://doi.org/10.5281/zenodo.7922054.
Full textAbstract:
Oxygen saturation is one of the important indicators of the health and movement of athletes. This indicator reflects the saturation of hemoglobin in the blood with oxygen. It is expressed as a percentage and reflects the amount of oxygen bound to hemoglobin in the blood. This article discusses the methodology, model, algorithm and monitoring program for athletes during competitions in order to prevent diseases caused by a lack of oxygen in the body
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Willekens, Frans L. A., Bregt Roerdinkholder-Stoelwinder, Yvonne A. M. Groenen-Döpp, et al. "Hemoglobin loss from erythrocytes in vivo results from spleen-facilitated vesiculation." Blood 101, no. 2 (2003): 747–51. http://dx.doi.org/10.1182/blood-2002-02-0500.
Full textAbstract:
Previous studies have shown that approximately 20% of hemoglobin is lost from circulating red blood cells (RBCs), mainly during the second half of the cells' life span. Because hemoglobin-containing vesicles are known to circulate in plasma, these vesicles were isolated. Flow cytometry studies showed that most RBC-derived vesicles contain hemoglobin with all hemoglobin components present. The hemoglobin composition of the vesicles resembled that of old RBCs. RBC cohort studies using isotope-labeled glycine have been described, which showed a continuous presence of this label in hemoglobin degradation products. The label concentration of these products increased during the second half of the RBC life span, accompanied by a decrease within the RBC. It is concluded that the hemoglobin loss from circulating RBCs of all ages can be explained by shedding hemoglobin-containing vesicles. This loss occurs predominantly in older RBCs. Apparently the spleen facilitates this process since asplenia vesicle retention within RBCs of all ages has been described, accompanied by an increase in the percentage of total HbA1. The present study shows that in old RBCs of asplenic individuals, the decrease of hemoglobin content per cell such as seen in old RBCs of control individuals is absent due to an increase in the absolute amount of HbA1c and HbA1e2. It is concluded that hemoglobin-containing vesicles within old RBCs are “pitted” by the spleen.
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Boezeman, Reinout PE, Doeke Boersma, Jan Wille, et al. "The significance of regional hemoglobin oxygen saturation values and limb-to-arm ratios of near-infrared spectroscopy to detect critical limb ischemia." Vascular 24, no. 5 (2016): 492–500. http://dx.doi.org/10.1177/1708538115613936.
Full textAbstract:
This study examines the application of near-infrared spectroscopy to noninvasively detect critical limb ischemia using regional hemoglobin oxygen saturation in percentage values and regional hemoglobin oxygen saturation limb-to-arm ratios. The regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios were calculated in 61 patients with critical limb ischemia (group A). Measurements were performed in rest at four fixed spots at the most affected lower limb and at a reference spot at both upper arms. Similar measurements were performed in the left lower limb of 30 age-matched control patients without peripheral arterial disease (group B). The regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios were significantly different at all measured spots between the groups (all p < 0.001), except for the regional hemoglobin oxygen saturation limb-to-arm ratios of the distal vastus lateralis ( p = 0.056). However, a broad overlap of individual regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios was found in both groups, which resulted in poor discriminative predictive value of single measurements. Single measurements of regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios at all measured spots have poor discriminative predictive value in detection of critical limb ischemia. Measurement of regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios at any of the measurement spots has no added value in detecting lower limb ischemia in individuals compared with current diagnostic modalities.
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Gheorghevici, Teodor Stefan, Bogdan Veliceasa, Bogdan Puha, Stefan Toader, Ioana Dana Alexa, and Ovidiu Alexa. "Preoperative Hemoglobin Dynamics in Patients with Trochanteric Fractures. A multivariate analysis." Revista de Chimie 69, no. 11 (2018): 3320–24. http://dx.doi.org/10.37358/rc.18.11.6739.
Full textAbstract:
Preoperative anemia is a common finding among geriatric patients with trochanteric fractures. We assessed the dynamics of hemoglobin and the factors that influence it. A total of 780 patients with trochanteric fractures were selected. Distribution by gender showed a slightly higher proportion of female patients (64.1%). The preoperative interval ranged from a few hours to 19 days. Hospital admission period varied from 1 to 49 days. Hemoglobin ranged from 4.80 to 17.40 g/dl; 43.1% of patients had individual values below the baseline. Individually, the hemoglobin value varied from a decrease of 9.33 g/dL to an increase of 11.97 g/dL, but the total study group recorded an average decrease of 0.96 � 1.75 g/dL. Hemoglobin had a downward trend directly correlated with the preoperative interval period. Decrease in hemoglobin was correlated with the percentage of blood lymphocytes, PLT/WBC ratio, prothrombin activity and APTT ratio. A low level of hemoglobin variation was associated with a shorter preoperative interval, reduced prothrombin time, prothrombin activity ] 100, INR ] 1.50 and APTT ] 30.