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Journal articles on the topic 'Hemoglobin threshold'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Milman, N., and T. Bergholt. "W384 POSTPARTUM ANEMIA - DEFINING THRESHOLD HEMOGLOBIN VALUES." International Journal of Gynecology & Obstetrics 119 (October 2012): S829. http://dx.doi.org/10.1016/s0020-7292(12)62106-7.

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2

Boban, Abijha Biju, Andrew Strike, Dhaval Patel, and Ania Rynarzewska. "Evaluating hemoglobin thresholds for blood transfusions in oncology patients admitted in the intensive care unit." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23319-e23319. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23319.

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e23319 Background: Current guidelines recommend transfusing at a hemoglobin (Hb) threshold of 7g/dl. There is a lack of evidence to support a specific threshold for transfusion in patients with active malignancy admitted to the Intensive Care Unit (ICU). This study attempts to determine an evidence-based threshold for blood transfusions in cancer. Methods: A retrospective study was done to study 561 patients with an active cancer diagnosis admitted to Northeast Georgia Medical Center ICU between 2017 and 2023 that received at least one unit of blood transfusion. Chi-Square test of association

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3

Skeie, Svein, Geir Thue, and Sverre Sandberg. "Interpretation of Hemoglobin A1c (HbA1c) Values among Diabetic Patients." Clinical Chemistry 47, no. 7 (2001): 1212–17. http://dx.doi.org/10.1093/clinchem/47.7.1212.

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Abstract Background: Few studies have examined patients’ views, knowledge, and understanding of glycohemoglobin A1c (HbA1c) testing. We explored such issues in patients with type 1 diabetes and used their statements to estimate analytical quality specifications for HbA1c testing. Methods: We recruited 201 patients from a hospital outpatient clinic. A questionnaire was used to collect information on diabetes characteristics, perceived knowledge of HbA1c, last HbA1c value, HbA1c target value, and thresholds for action. Patients were asked to indicate the magnitude of change in HbA1c from 9.4% th

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Međedović, Bojan, and Jovan Plećaš. "The importance of monitoring saturated oxygen values in hemoglobin in the sports diagnostics." TIMS. Acta 15, no. 1 (2021): 47–52. http://dx.doi.org/10.5937/timsact15-32840.

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Cardiorespiratory performance is one of the most important determinants of success in sports activities. In order to better prepare for sports challenges, the athletes must be exposed to appropriate training which should be based on individualized physiological parameters during activity. Even though training intensity can be determined in many different ways, the endurance training intensity is often quantified by the lactate thresholds obtained from the blood sampling or the ventilator thresholds obtained from the gas exchange. These data represent delayed indirect indicators of an increased

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Vedantam, Aditya, Jose-Miguel Yamal, Maria Laura Rubin, Claudia S. Robertson, and Shankar P. Gopinath. "Progressive hemorrhagic injury after severe traumatic brain injury: effect of hemoglobin transfusion thresholds." Journal of Neurosurgery 125, no. 5 (2016): 1229–34. http://dx.doi.org/10.3171/2015.11.jns151515.

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OBJECT There is limited literature available to guide transfusion practices for patients with severe traumatic brain injury (TBI). Recent studies have shown that maintaining a higher hemoglobin threshold after severe TBI offers no clinical benefit. The present study aimed to determine if a higher transfusion threshold was independently associated with an increased risk of progressive hemorrhagic injury (PHI), thereby contributing to higher rates of morbidity and mortality. METHODS The authors performed a secondary analysis of data obtained from a recently performed randomized clinical trial st

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6

Berman, Brianna. "Patient Blood Management." Anesthesia eJournal 8, no. 3 (2021): 1–2. http://dx.doi.org/10.18776/4dk5ra98.

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Impact Statement: Patient blood management (PBM) recommendations can help providers manage anemia and assist in transfusion-related decision-making. Introduction: Blood transfusions are often a necessary treatment for operative patients, but they are not without potential complications, including hemolytic reactions, and even death. Establishing parameters and guidelines for transfusions in patients undergoing an operation is imperative in treating them safely and effectively; patient blood management protocols provide these guidelines. Literature review: Patient blood management (PBM) is base

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Kunihiro, Yamada, Asanoi Hidetsugu, Oda Yoshitaka, et al. "A hemoglobin threshold of risk for worsening heart failure." Journal of Cardiac Failure 10, no. 5 (2004): S167. http://dx.doi.org/10.1016/j.cardfail.2004.08.051.

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8

Barasinski, Chloé, Marine Pranal, Stéphanie Léger, Anne Debost-Legrand, and Françoise Vendittelli. "Change in Hemoglobin Was Not a Reliable Diagnostic Screening Test for Postpartum Hemorrhage: A French Prospective Multicenter Cohort Study (HERA Study)." Healthcare 11, no. 8 (2023): 1111. http://dx.doi.org/10.3390/healthcare11081111.

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Changes between pre- and postpartum hemoglobin might be useful for optimizing the postpartum diagnosis of postpartum hemorrhage (PPH), defined as a blood loss exceeding 500 mL. This study’s principal objective was to estimate the mean change in hemoglobin (between pre/post-delivery hemoglobin) among women with vaginal deliveries and PPH. The secondary objectives were to analyze: hemoglobin changes according to blood volume loss, the appropriateness of standard thresholds for assessing hemoglobin loss, and the intrinsic and extrinsic performances of these threshold values for identifying PPH. F

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9

Handel, James, and Eddy Lang. "Transfusion strategy for acute upper gastrointestinal bleeding." CJEM 17, no. 5 (2015): 582–85. http://dx.doi.org/10.1017/cem.2014.76.

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Clinical questionDoes a hemoglobin transfusion threshold of 70 g/L yield better patient outcomes than a threshold of 90 g/L in patients with acute upper gastrointestinal bleeding?Article chosenVillanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368(1):11-21.Study objectivesThe authors of this study measured mortality, from any cause, within the first 45 days, in patients with acute upper gastrointestinal bleeding, who were managed with a hemoglobin threshold for red cell transfusion of either 70 g/L or 90 g/L. The secondar

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10

Deschmann, Emöke, Christof Dame, Martha C. Sola-Visner, et al. "Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates." JAMA Network Open 7, no. 6 (2024): e2417431. http://dx.doi.org/10.1001/jamanetworkopen.2024.17431.

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ImportanceRed blood cell (RBC) transfusion is a common medical intervention to treat anemia in very preterm neonates; however, best transfusion practices, such as thresholds, remain uncertain.ObjectiveTo develop recommendations for clinicians on the use of RBC transfusions in very preterm neonates.Evidence ReviewAn international steering committee reviewed evidence from a systematic review of 6 randomized clinical trials (RCTs) that compared high vs low hemoglobin-based or hematocrit-based transfusion thresholds. The steering committee reached consensus on certainty-of-evidence ratings and wor

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Garg, Amit X., Neal Badner, Sean M. Bagshaw, et al. "Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial." Journal of the American Society of Nephrology 30, no. 7 (2019): 1294–304. http://dx.doi.org/10.1681/asn.2019010004.

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BackgroundSafely reducing red blood cell transfusions can prevent transfusion-related adverse effects, conserve the blood supply, and reduce health care costs. Both anemia and red blood cell transfusion are independently associated with AKI, but observational data are insufficient to determine whether a restrictive approach to transfusion can be used without increasing AKI risk.MethodsIn a prespecified kidney substudy of a randomized noninferiority trial, we compared a restrictive threshold for red blood cell transfusion (transfuse if hemoglobin<7.5 g/dl, intraoperatively and postoperativel

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12

Eagles, ME, MK Tso, and RL Macdonald. "P.093 Hemoglobin values, fluctuations from baseline, and transfusion as predictors of outcome following aneurysmal subarachnoid hemorrhage." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (2018): S41. http://dx.doi.org/10.1017/cjn.2018.195.

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Background: Anemia following aneurysmal subarachnoid hemorrhage (aSAH) has been associated with poor outcome, but complications from transfusion have limited aggressive management of anemic patients. This study examined the relationship between hemoglobin levels, transfusion and outcome following aSAH. Methods: We performed a post-hoc analysis of the CONSCIOUS-1 trial. Poor outcome was defined as a 3-month modified Rankin Scale > 2. Minimum hemoglobin levels were evaluated as predictors of outcome using logistic regression analysis, ROC curve analysis, and LOWESS curves. Propensity score ma

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Ahmad, Maud, Cyrus Hsia, Benjamin Chin-Yee, Ian Chin-Yee, and Benjamin Hedley. "Laboratory Reference Intervals Influence Referral Patterns for Hemoglobin Abnormalities in the Ontario Virtual Care System." Blood 144, Supplement 1 (2024): 7569. https://doi.org/10.1182/blood-2024-211150.

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This retrospective cross-sectional study investigates the impact of laboratory-specific hemoglobin reference intervals on electronic consultation (eConsult) referral patterns for suspected anemia and elevated hemoglobin at a tertiary care center in London, Ontario that serves Southwestern Ontario.The study analyzed referrals through the Ontario Telemedicine Network's eConsult platform for hemoglobin abnormalities, excluding patients under 18 years old, between July 1, 2019, and June 30, 2023.The main outcome measures were influence of hemoglobin reference intervals on the referral patterns for

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Ahmad, Maud, Benjamin Chin-Yee, Ian H. Chin-Yee, Ben Hedley, and Cyrus C. Hsia. "Laboratory reference intervals influence referral patterns for hemoglobin abnormalities in the Ontario virtual care system." PLOS Digital Health 3, no. 8 (2024): e0000580. http://dx.doi.org/10.1371/journal.pdig.0000580.

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This retrospective cross-sectional study investigates the impact of laboratory-specific hemoglobin reference intervals on electronic consultation (eConsult) referral patterns for suspected anemia and elevated hemoglobin at a tertiary care center in London, Ontario that serves Southwestern Ontario. The study analyzed referrals through the Ontario Telemedicine Network’s eConsult platform for hemoglobin abnormalities, excluding patients under 18 years old, between July 1, 2019, and June 30, 2023.The main outcome measures were influence of hemoglobin reference intervals on the referral patterns fo

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15

Yamal, Jose-Miguel, M. Laura Rubin, Julia S. Benoit, et al. "Effect of Hemoglobin Transfusion Threshold on Cerebral Hemodynamics and Oxygenation." Journal of Neurotrauma 32, no. 16 (2015): 1239–45. http://dx.doi.org/10.1089/neu.2014.3752.

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16

Holst, Lars B., Nicolai Haase, Jørn Wetterslev, et al. "Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock." New England Journal of Medicine 371, no. 15 (2014): 1381–91. http://dx.doi.org/10.1056/nejmoa1406617.

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17

Ahn, J., L. J. Soril, L. E. Leggett, et al. "LO077: A restrictive transfusion strategy decreases mortality, re-bleeding and adverse events in hemodynamically stable patients with acute upper gastrointestinal bleeding: findings from a systematic review and meta-analysis of randomized controlled trials." CJEM 18, S1 (2016): S56—S57. http://dx.doi.org/10.1017/cem.2016.114.

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Introduction: Acute upper gastrointestinal bleeding is a potentially life-threatening medical emergency that frequently requires red blood cell (RBC) transfusions. However, the optimal hemoglobin thresholds for transfusion is controversial. The objective of this study was to establish the most efficacious transfusion threshold. Methods: A systematic review of the published literature was completed. MEDLINE, Health technology assessment database, Cochrane central register, Cochrane database of systematic reviews, and EMBASE were searched from inception to May 2015 using search terms including “

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18

Houben, Nina A. M., Suzanne Fustolo-Gunnink, Karin Fijnvandraat, et al. "Red Blood Cell Transfusion in European Neonatal Intensive Care Units, 2022 to 2023." JAMA Network Open 7, no. 9 (2024): e2434077. http://dx.doi.org/10.1001/jamanetworkopen.2024.34077.

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ImportanceRed blood cell (RBC) transfusions are frequently administered to preterm infants born before 32 weeks of gestation in the neonatal intensive care unit (NICU). Two randomized clinical trials (Effects of Transfusion Thresholds on Neurocognitive Outcomes of Extremely Low-Birth-Weight Infants [ETTNO] and Transfusion of Prematures [TOP]) found that liberal RBC transfusion thresholds are nonsuperior to restrictive thresholds, but the extent to which these results have been integrated into clinical practice since publication in 2020 is unknown.ObjectiveTo describe neonatal RBC transfusion p

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19

Mosser, Nina, Markus Tilp, Gudrun Schappacher-Tilp, Annika Kruse, and Gerhard Tschakert. "Comparison of local muscle oxygenation and whole-body VO2 during incremental exercise." Current Issues in Sport Science (CISS) 9, no. 4 (2024): 043. http://dx.doi.org/10.36950/2024.4ciss043.

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The use of near-infrared spectroscopy (NIRS) in sports science has become increasingly important in the past few years (Perrey et al., 2024). One application is to determine thresholds from different NIRS parameters like oxygenated (O2Hb) or deoxygenated (HHb) hemoglobin to distinguish between hard and severe-intensity exercise (Caen et al., 2018). Such applications are frequently validated by comparison to established threshold determination concepts. However, it is not yet known which of the two parameters is more closely related to classical concepts. Therefore, the aim of this project was

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Park, Jungchan, Ji-hye Kwon, Seung-Hwa Lee, et al. "Intraoperative blood loss may be associated with myocardial injury after non-cardiac surgery." PLOS ONE 16, no. 2 (2021): e0241114. http://dx.doi.org/10.1371/journal.pone.0241114.

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Background This study aimed to evaluate the association between intraoperative blood loss and myocardial injury after non-cardiac surgery (MINS), which is a severe and common postoperative complication. Methods We compared the incidence of MINS based on significant intraoperative bleeding, defined as an absolute hemoglobin level < 7 g/dL, a relative hemoglobin level less than 50% of the preoperative measurement, or need for packed red cell transfusion. We also estimated a threshold for intraoperative hemoglobin level associated with MINS. Results We stratified a total of 15,926 non-cardiac

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21

Cheng, Xiaosong, Liangliang Zhang, Bo Cao, and Chengjin Zhao. "Correlation between serum hemoglobin levels and bone mineral density in adults: A cross-sectional study." Medicine 103, no. 37 (2024): e39612. http://dx.doi.org/10.1097/md.0000000000039612.

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Serum hemoglobin plays an important role in bone metabolism. However, the association between serum hemoglobin levels and bone mineral density (BMD) remains unclear. Therefore, this study aimed to explore the relationship between serum hemoglobin levels and lumbar spine BMD in adults. We conducted a cross-sectional study by utilizing data from the National Health and Nutrition Examination Survey from 2011 to 2018. The serum hemoglobin level was examined as an independent variable, while the lumbar spine BMD was utilized as the dependent variable. Weighted multivariate linear regression models

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22

Gupta, Pranjal B., Vince M. DeMario, Raj M. Amin, et al. "Patient Blood Management Program Improves Blood Use and Clinical Outcomes in Orthopedic Surgery." Anesthesiology 129, no. 6 (2018): 1082–91. http://dx.doi.org/10.1097/aln.0000000000002397.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Although randomized trials show that patients do well when given less blood, there remains a persistent impression that orthopedic surgery patients require a higher hemoglobin transfusion threshold than other patient populations (8 g/dl vs. 7 g/dl). The authors tested the hypothesis in orthopedic patients that implementation of a patient blood management program encouraging a hemoglobin threshold less than 7 g/dl results in decreased blood use with no change in clinical outcome

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23

Parikh, Shruti, Taylor Bentz, Samuel Crowley, Seth Greenspan, Ana Costa, and Sergio Bergese. "Perioperative Blood Management." Journal of Clinical Medicine 14, no. 11 (2025): 3847. https://doi.org/10.3390/jcm14113847.

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Perioperative blood management strategies include evidence-based guidelines to efficiently manage blood products and transfusions while minimizing blood loss and improving patient outcomes. Perioperative Medicine has made evident that anemia is often under-recognized and not appropriately addressed prior to surgery. Early recognition and correction of anemia is imperative for better surgical optimization, fewer transfusions perioperatively, and improved outcomes. Patient blood management utilize evidence-based guidelines for the establishment of a framework to promote treatment of the causes o

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Kovačević, Dražen, Marko Cincović, Mira Majkić, et al. "Analytical and Clinical Interference of Sample Hemolysis in Evaluating Blood Biochemical and Endocrine Parameters in Cows." Animals 14, no. 12 (2024): 1773. http://dx.doi.org/10.3390/ani14121773.

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Hemolysis is a common cause of errors in laboratory tests as it affects blood parameters and leads to a positive or negative bias. This study aims to examine the relationship between the level of hemolysis (expressed as cell-free hemoglobin concentration, g/L) and the variability of metabolic and endocrine parameters and to determine the threshold level of hemolysis that causes an analytically and clinically significant bias for the twenty most frequently examined blood parameters in cows. Paired blood samples of 10 mL each were obtained from 30 cows. One was subjected to mechanical trauma and

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Turnes, Tiago, Rafael Penteado dos Santos, Rafael Alves de Aguiar, Thiago Loch, Leonardo Trevisol Possamai, and Fabrizio Caputo. "Association Between Deoxygenated Hemoglobin Breaking Point, Anaerobic Threshold, and Rowing Performance." International Journal of Sports Physiology and Performance 14, no. 8 (2019): 1103–9. http://dx.doi.org/10.1123/ijspp.2018-0675.

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Purpose: To compare the intensity and physiological responses of deoxygenated hemoglobin breaking point ([HHb]BP) and anaerobic threshold (AnT) during an incremental test and to verify their association with 2000-m rowing-ergometer performance in well-trained rowers. Methods: A total of 13 male rowers (mean [SD] age = 24 [11] y and = 63.7 [6.1] mL·kg−1·min−1) performed a step incremental test. Gas exchange, vastus lateralis [HHb], and blood lactate concentration were measured. Power output, , and heart rate of [HHb]BP and AnT were determined and compared with each other. A 2000-m test was perf

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Chegondi, Madhuradhar, Jun Sasaki, André Raszynski, and Balagangadhar R. Totapally. "Hemoglobin Threshold for Blood Transfusion in a Pediatric Intensive Care Unit." Transfusion Medicine and Hemotherapy 43, no. 4 (2015): 297–301. http://dx.doi.org/10.1159/000446253.

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Péju, Edwige, and Frédéric Pène. "Anemia in septic shock: which transfusion thresholds?" Médecine Intensive Réanimation 30, no. 3 (2021): 237–46. http://dx.doi.org/10.37051/mir-00061.

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Anemia is a frequent condition in intensive care units (ICU), most especially in septic patients. The hemoglobin level is a major determinant of oxygen transport. Red blood cell transfusion represents the main therapeutic of anemia in the ICU, and the only one able to rapidly increase the hemoglobin level in critical care. Overall, about half of septic patients will require red blood cell transfusion in the ICU and after discharge. Interventional randomized studies have demonstrated the safety and possibly a benefit of restrictive transfusion strategies in the ICU. Hence national and internati

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Hebert, Nicolas, Rakotoson Marie Georgine, Gwellaouen Bodivit, et al. "Fetal Hemoglobin Measurement per Red Blood Cell Provides Biological and Clinical Protective Thresholds." Blood 134, Supplement_1 (2019): 1008. http://dx.doi.org/10.1182/blood-2019-126727.

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Introduction: Fetal hemoglobin (HbF) expression is a major modulator of sickle cell disease (SCD) severity by decreasing the HbS polymerization. However, the distribution of HbF in red blood cells (RBC) is heterogeneous in SCD patients. In the hypothesis of an HbF "threshold" in RBCs for inhibiting the HbS polymerization, accurate measurement of the HbF content in each red blood cell (HbF/RBC) is mandatory. To this purpose we developed a new and accurate method allowing the direct measurement of HbF content per RBC. Thanks to it, as a proof of concept, we analyzed HbF distribution and content

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Costa, Renato Magalhães, Ana Paula Pina, Andrea Silva De Carvalho, Urbino da Rocha Tunes, and Roberta Santos Tunes. "USO DA HEMOGLOBINA GLICADA NO DIAGNÓSTICO DE DIABETES MELLITUS – REVISÃO DE LITERATURA USE OF GLYCATED HEMOGLOBIN IN THE DIAGNOSIS OF DIABETES MELLITUS - LITERATURE REVIEW." Revista da Faculdade de Odontologia da Universidade Federal da Bahia 50, no. 1 (2020): 79–87. http://dx.doi.org/10.9771/revfo.v50i1.37121.

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A Organização Mundial de Saúde considera Diabetes Mellitus (DM) umapandemia e, consequentemente, um sério problema de saúde pública.Classicamente, os exames laboratoriais Glicemia em Jejum e TesteOral de Tolerância à Glicose são realizados para o diagnóstico de DM.Recentemente, a Associação Americana de Diabetes (ADA) preconizou ouso da Hemoglobina Glicada (HbA1C), com limiar de 6,5%, para essa finalidade.Esse trabalho tem como objetivo revisar a literatura acerca da utilizaçãode Hemoglobina Glicada no diagnóstico de pacientes diabéticos.A HbA1C é o exame laboratorial padrão ouro para o acompa

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Hasbi, Hasbi, Andi Mutfaidah, Renny Fatmyah Utamy, et al. "The Value of Hematocrit, Hemoglobin, and Lymphocytes of Lactating Friesian Holstein with Supplementation of Urea Molasses Multi-Nutrient Block Containing Cement Substituted by Tapioca Meal." BIO Web of Conferences 177 (2025): 02001. https://doi.org/10.1051/bioconf/202517702001.

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Urea Molasses Multi-nutrient Block (UMMB) is a compact, nutrient-rich ruminant feed supplement. Generally, UMMB adhesive material is the cement that keeps the UMMB in shape so it doesn't crumble. Tapioca meal can be an adhesive for UMMB production because it has a high starch content. This study aimed to determine the value of hematocrit, hemoglobin, and lymphocytes of lactating Friesian Holstein fed UMMB substituted cement adhesive by tapioca meal. Twenty (20) lactating Friesian Holstein was divided into 5 dietary groups in a completely randomized design, and each treatment had 4 cows as repl

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31

Hong, Keum-Shik, and Noman Naseer. "Reduction of Delay in Detecting Initial Dips from Functional Near-Infrared Spectroscopy Signals Using Vector-Based Phase Analysis." International Journal of Neural Systems 26, no. 03 (2016): 1650012. http://dx.doi.org/10.1142/s012906571650012x.

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In this paper, we present a systematic method to reduce the time lag in detecting initial dips using a vector-based phase diagram and an autoregressive moving average with exogenous signals (ARMAX) model-based [Formula: see text]-step-ahead prediction algorithm. With functional near-infrared spectroscopy (fNIRS), signals related to mental arithmetic and right-hand clenching are acquired from the prefrontal and left primary motor cortices, respectively. The interrelationship between oxygenated hemoglobin, deoxygenated hemoglobin, total hemoglobin and cerebral oxygen exchange are related to init

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Anamisa, Devie Rosa. "Rancang Bangun Metode OTSU Untuk Deteksi Hemoglobin." S@CIES 5, no. 2 (2015): 106–10. http://dx.doi.org/10.31598/sacies.v5i2.64.

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Darah yang mengalir dalam tubuh mempunyai kemampuan untuk dideteksi dengan bantuan citra. Fungsi utama dari darah, khususnya sel darah merah,yang dikenal sebagai eritrosit adalah mengangkut hemoglobin, dan seterusnya mengangkut oksigen dari paru-paru ke jaringan. Selain mengangkut hemoglobin, darah juga mempunyai fungsi lain. Hemoglobin dalam darah manusia merupakan dapur asam-basa (seperti juga pada kebanyakan protein), sehingga hemoglobin bertanggung jawab untuk sebagian besar daya transportasi di seluruh darah. Seperti yang telah disebutkan sebelumnya bahwa fungsi terpenting dari sel darah

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Nieves Garcia-Casal, Maria, Sant-Rayn Pasricha, Juan Pablo Peña-Rosas, Katherine Colman, and Elizabeth Centeno-Tablante. "WHO Hemoglobin Thresholds to Define Anemia in Clinical Medicine and Public Health: A Scoping Exercise." Current Developments in Nutrition 4, Supplement_2 (2020): 189. http://dx.doi.org/10.1093/cdn/nzaa043_040.

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Abstract Objectives WHO is reviewing the use and interpretation of hemoglobin thresholds for assessing iron status in individuals and populations following established evidence-informed guideline development procedures to culminate in updated guidelines for clinical and public health use. Methods To define priorities and identify key questions a scoping exercise was developed via a two-stage international consultation based on the Child Health and Nutrition Research Initiative method. The first survey allowed respondents to suggest priorities, and the second asked respondents to rank the key q

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Maiya, Arun G., Anche Parameshwar, Manjunath Hande, and Vinayak Nandalike. "Relationship Between Glycated Hemoglobin and Vibration Perception Threshold in Diabetic Peripheral Neuropathy." International Journal of Lower Extremity Wounds 19, no. 2 (2019): 120–24. http://dx.doi.org/10.1177/1534734619882173.

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Foot ulcers, infections, and deformity are some of the major sources of mortality and morbidity among the diabetic population. The relationship between glycated hemoglobin (HbA1c) and diabetic peripheral neuropathy (DPN) has been well established. There is a dearth of literature on the relationship between vibration perception threshold (VPT) and HbA1c values. So, the objective of the study was to determine the strength of linear relationship between HbA1c levels and vibration perception threshold in DPN. This cross-sectional study was conducted at Kasturba Hospital, Manipal, and diabetic foot

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Mazzatenta, Andrea, Margherita Maffei, Camillo Di Giulio, and Giampiero Neri. "COVID-19 Smell Impairment and Crosstalk with Hypoxia Physiology." Life 12, no. 9 (2022): 1408. http://dx.doi.org/10.3390/life12091408.

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Since its apomorphic appearance in 2019, severe acute respiratory syndrome Coronavirus type 2 (SARS-CoV-2) nowadays circulates as a plesiomorphic human virus in several synapomorphic variants. The respiratory tract is the most important site of infection, the viral effects in the lungs are well described, and more than half of the patients could develop shortness of breath and dyspnea and require ventilatory support. The physiological sign of this condition is the decrease in the partial pressure of oxygen in the blood, leading to acute hypoxia, which could be a factor in the disease. In sever

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Atakan, Besnek, Şanlı Ahmet Metin, and Türkoğlu Mehmet Erhan. "Threshold hemoglobin level for delayed cerebral ischemia: A single-center retrospective analysis." Heliyon 10, no. 23 (2024): e40551. https://doi.org/10.1016/j.heliyon.2024.e40551.

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Oliva, Esther N., Borislav D. Dimitrov, Arianna D’Angelo, Frank Benedetto, and Francesco Nobile. "Hemoglobin Level Threshold in Myelodysplastic Syndrome: Cardiac Hypertrophy and Quality of Life." Blood 104, no. 11 (2004): 1444. http://dx.doi.org/10.1182/blood.v104.11.1444.1444.

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Abstract Anemia is a frequent complication in myelodysplastic syndrome (MDS). Treatment with recombinant human epoetin, though effective in up to 40% of patients, is generally limited by financial constraints. On the other hand, anemia has been associated with increased cardiac morbidity and mortality. The main hemodynamic factor is the increased cardiac output mediated by lower afterload, higher preload and positive inotropic and chronotropic effects, leading to gradual cardiac enlargement and left ventricular hypertrophy (LVH). The important relationship between anemia and cardiac morbidity

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Allaf, Bichr, Corinne Pondarre, Slimane Allali та ін. "Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening". Clinical Chemistry and Laboratory Medicine (CCLM) 59, № 1 (2021): 209–16. http://dx.doi.org/10.1515/cclm-2020-0803.

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AbstractObjectivesNewborn screening (NBS) for β-thalassemia is based on measuring the expression of the hemoglobin A (HbA) fraction. An absence or very low level of HbA at birth may indicate β-thalassemia. The difficulty is that the HbA fraction at birth is correlated with gestational age (GA) and highly variable between individuals. We used HbA expressed in multiples of the normal (MoM) to evaluate relevant thresholds for NBS of β-thalassemia.MethodsThe chosen threshold (HbA≤0.25 MoM) was prospectively applied for 32 months in our regional NBS program for sickle cell disease, for all tests pe

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Tsui, Albert K. Y., Philip A. Marsden, C. David Mazer, et al. "Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 1 (2014): R13—R25. http://dx.doi.org/10.1152/ajpregu.00411.2013.

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Tissue hypoxia likely contributes to anemia-induced organ injury and mortality. Severe anemia activates hypoxia-inducible factor (HIF) signaling by hypoxic- and neuronal nitric oxide (NO) synthase- (nNOS) dependent mechanisms. However, organ-specific hemoglobin (Hb) thresholds for increased HIF expression have not been defined. To assess organ-specific Hb thresholds for tissue hypoxia, HIF-α (oxygen-dependent degradation domain, ODD) luciferase mice were hemodiluted to mild, moderate, or severe anemia corresponding to Hb levels of 90, 70, and 50 g/l, respectively. HIF luciferase reporter activ

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Yang, Jun, Pi-jun Yan, Qin Wan, and Hua Li. "Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records." Journal of Diabetes Research 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/2835981.

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Objective. To investigate the relationship between hemoglobin levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM). Methods. 1511 patients with T2DM were included in the study. DPN was diagnosed based on symptoms, signs, and laboratory tests. Hemoglobin was defined as both a continuous variable and a quartile category variable. We compared patient characteristics between the no diabetic peripheral neuropathy (NDPN) and DPN groups. Logistic regression was conducted to investigate the association of DPN with hemoglobin in all T2DM patients. Linear regression was als

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Saprina, T. V., N. N. Musina, T. S. Prokhorenko, Ya S. Slavkina, and A. P. Zima. "The question of differential diagnosis of anemia in diabetes mellitus." Diabetes mellitus 26, no. 2 (2023): 131–44. http://dx.doi.org/10.14341/dm12979.

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BACKGROUND: High prevalence of anemia in diabetes mellitus (DM) determines the relevance of studying its pathogenetic aspects, the role of anemia in DM complications development and the issue of differential diagnosis between iron deficiency anemia (IDA) and anemia of chronic disease (ACD)).AIM: To establish the diagnostic value of classical parameters for diagnosing anemia in DM and propose an optimized algorithm for the differential diagnosis of ACD and IDA in DM type 1 and 2 using new markers.MATERIALS AND METHODS: The observational, single-centre, comparative, controlled, single-stage stud

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Protasov, Konstantin V., Olga A. Barakhtenko, and Elena V. Batunova. "ACUTE MYOCARDIAL INJURY AFTER SURGICAL LUNG RESECTION: INCIDENCE, CLINICAL FEATURES, PREDICTORS." Complex Issues of Cardiovascular Diseases 13, no. 4 (2025): 159–69. https://doi.org/10.17802/2306-1278-2024-13-4-13-159-169.

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HighlightsAcute perioperative myocardial injury develops in 38.5% of patients with non – small cell lung cancer and is associated with the ThRCRI major cardiac events risk index, preoperative hemoglobin level and postoperative heart rate. Aim. To determine the incidence and predictors of acute myocardial injury after surgical treatment of patients with non – small cell lung cancer (NSCLC).Methods. The study included 104 men aged 63.0 [58–67] years who underwent lung resection for NSCLC. Blood levels of cardiac troponin I (cTnI) were determined before and 24 and 48 hours after surgery. Myocardi

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Jalali, Mir Mohammad, Ziba Zahiri Sorouri, Vahid Aghsaghloo, and Hedieh Ramezani. "A Comparative Study of Hearing Threshold in Women With and Without Iron Deficiency Anemia." Journal of Guilan University of Medical Sciences 30, no. 3 (2021): 194–203. http://dx.doi.org/10.32598/jgums.30.3.220.4.

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Background: Iron Deficiency Anemia (IDA) is the most common form of anemia. Understanding the relationship between IDA and hearing loss may provide new insights into managing hearing loss. Objective This study aimed to investigate the relationship between IDA and hearing loss in women aged 12-45 years referred to Amir Al-Momenin and Al-Zahra hospitals in Rasht City, Iran. Methods: In this case-control study, 315 women aged 12-45 years with IDA and without IDA were included. Study groups were matched by age. The amount of hemoglobin (based on the last blood test in the past month) of the subjec

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Valentine, Stacey L., Jenifer R. Lightdale, Chau M. Tran, et al. "Assessment of Hemoglobin Threshold for Packed RBC Transfusion in a Medical-Surgical PICU." Pediatric Critical Care Medicine 15, no. 2 (2014): e89-e94. http://dx.doi.org/10.1097/pcc.0000000000000033.

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Oliva, Esther Natalie, Borislav D. Dimitrov, Frank Benedetto, Arianna D’Angelo, and Francesco Nobile. "Hemoglobin level threshold for cardiac remodeling and quality of life in myelodysplastic syndrome." Leukemia Research 29, no. 10 (2005): 1217–19. http://dx.doi.org/10.1016/j.leukres.2005.03.004.

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Andreev, Dmitrii, Asan Kashurnikov, and Aleksandr Zavyalov. "Colorectal cancer screening: foreign guidelines on fecal immunochemical test cut-off (review)." Problems in oncology 67, no. 4 (2021): 456–62. http://dx.doi.org/10.37469/0507-3758-2021-67-4-456-462.

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Introduction. According to WHO data for 2020, colorectal cancer occupies first (highest) position (excluding non-melanoma skin cancer) in the top ranking list of the most frequent cancers in the Russian Federation. Colorectal cancer screening plays a pivotal role in early diagnosis and treatment. The best positive threshold values for hemoglobin concentration in a quantitative fecal immunochemical test (FIT) are postulated in a fraction of foreign recommendations. We reviewed the FIT cut-off values in those clinical guidelines. Materials and methods. The relevant publications were retrieved fr

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Römers, Luuk H. L., Charlotte Bakker, Nathalie Dollée, et al. "Cutaneous Mitochondrial Po2, but Not Tissue Oxygen Saturation, Is an Early Indicator of the Physiologic Limit of Hemodilution in the Pig." Anesthesiology 125, no. 1 (2016): 124–32. http://dx.doi.org/10.1097/aln.0000000000001156.

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Abstract Background Hemodilution is a consequence of fluid replacement during blood loss and is limited by the individual ability to compensate for decreasing hemoglobin level. We tested the ability of a novel noninvasive method for measuring cutaneous mitochondrial Po2 (mitoPo2) to detect this threshold early. Methods Anesthetized and ventilated pigs were hemodynamically monitored and randomized into a hemodilution (n = 12) or a time control (TC) group (n = 14). MitoPo2 measurements were done by oxygen-dependent delayed fluorescence of protoporphyrin IX after preparation of the skin with 20%

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Sari, Dewi Puspita, and Maryati Sutarno. "Pengaruh Konseling Prenatal terhadap Kadar Hemoglobin Ibu Hamil dengan Risiko Anemia di Wilayah Kerja TPMB Dewi Puspita Sari Jakarta Timur." MAHESA : Malahayati Health Student Journal 5, no. 2 (2025): 758–65. https://doi.org/10.33024/mahesa.v5i2.16722.

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ABSTRACT Anemia is a prevalent nutritional issue among pregnant women, often stemming from iron deficiency and insufficient awareness regarding hemoglobin levels. Utilizing video-based prenatal counseling can enhance pregnant women's knowledge in this regard. This study aimed to assess the effectiveness of prenatal counseling in improving hemoglobin levels among pregnant women at risk of anemia within the TPMB operational area. The research employed a quasi-experimental design featuring experimental and control groups, with pretest and posttest evaluations. The sample consisted of 40 women in

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Pine, Alexander B., Eun-Ju Lee, Mikkael A. Sekeres, et al. "North American Cooperative Group Members' Patterns of Blood Products Transfusion for Patients with Acute Leukemia." Blood 126, no. 23 (2015): 1138. http://dx.doi.org/10.1182/blood.v126.23.1138.1138.

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Abstract Background. Transfusion of blood products is an integral component of the management of patients with acute leukemias. However, high-quality evidence and clinical trial data to support specific practices of blood product transfusion in this population are limited. We hypothesized that there is wide variation in blood product transfusion practices among providers in North America who manage patients with acute leukemia. Methods. A 30-question web-based survey about transfusion practices was emailed to members of the Eastern Cooperative Oncology Group (ECOG)-ACRIN Cancer Research Group,

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Ghanim, Majd T., Jennifer H. Voeks, and Julie Kanter. "Transfusion Practices Among Hematology/Oncology Healthcare Professionals." Blood 132, Supplement 1 (2018): 2552. http://dx.doi.org/10.1182/blood-2018-99-111925.

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Abstract Introduction/Background: There are no evidence-based guidelines for optimal transfusion practices for patients undergoing chemotherapy and stem cell transplant. There are minimal low-quality studies regarding transfusion thresholds as well as the efficacy of pre-transfusion medications (to reduce febrile non-hemolytic transfusion reactions) for these patients. To pursue a prospective quality improvement study, it is important to know the current transfusion standards used by practitioners regarding: 1) transfusion thresholds for platelets and red blood cells and 2) routine use of pre

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