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Journal articles on the topic 'Hemoglobina fetal'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Batista, Gabriela Silva, Nayhan Andrade dos Santos, Valéria Bastos Marquetti, Wesley Blanco Mota, and Alessandra Dos Santos Danziger Silvério. "Hemoglobinopatias." Revista de Medicina 99, no. 3 (2020): 246–50. http://dx.doi.org/10.11606/issn.1679-9836.v99i3p246-250.

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formados pela combinação de duas cadeias polipeptídicas do “tipo α” com duas cadeias do “tipo β”, sendo Hb A1, Hb A2 e Hb Fetal os três principais tipos de hemoglobinas no adulto normal. As hemoglobinopatias são doenças causadas por mutações que afetam os genes de globinas, que resultam em alterações estruturais e/ou funcionais das moléculas de hemoglobina. Dentre as hemoglobinas variantes, as mais frequentes na população brasileira são a hemoglobina S e C. O objetivo é detectar hemoglobinas anormais em uma população acadêmica de Alfenas-MG. Para a realização do estudo, foram coletadas 336 amo

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2

Castillo, Martha, and Ana Lucia Oliveros. "Caracterización de alteraciones en la molécula de hemoglobina en afrodescendientes colombianos." Nova 12, no. 22 (2014): 151. http://dx.doi.org/10.22490/24629448.1039.

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Caracterizar alteraciones de la molécula de hemoglobina en afrodescendientes entre 18 a 50 años, a través de hemograma, estudio de sangre periférico, proteína C Reactiva, ferritina sérica, receptor soluble de transferrina sRTf y electroforesis de Hemoglobina. Materiales y métodos: Esta investigación contó con un total de 56 muestras: 10 hombres y 46 mujeres. Resultados: La población en estudio perteneciente al Distrito de Aguablanca en la Ciudad de Cali presentó alteraciones en la cadena de hemoglobina asociada a Hemoglobina S, Hemoglobina C y posible talasemias por presencia de Hemoglobina Fe

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3

Costa, Vânia Aparecida da, Maria Júlia Acedo, Newton Carlos Polimeno, and Carmen Sílvia Bertuzzo. "Contribuição para a estimativa da freqüência populacional da Persistência Hereditária da Hemoglobina Fetal no Brasil." Cadernos de Saúde Pública 18, no. 5 (2002): 1469–71. http://dx.doi.org/10.1590/s0102-311x2002000500040.

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Persistência Hereditária de Hemoglobina Fetal (PHHF) é uma condição clinicamente benigna, caracterizada pela síntese contínua da HbF na vida adulta, sem alterações hematológicas. A PHHF funciona como um modulador de gravidade em várias hemoglobinopatias, razão pela qual torna-se importante conhecer a sua freqüência em nosso meio. Desse modo, por intermédio da análise de 1.846 doadores voluntários de sangue da região de Bragança Paulista, São Paulo, procuramos contribuir para a estimativa dessa freqüência populacional. Realizou-se uma análise qualitativa das hemoglobinas pela eletroforese em ge

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4

Magalhães, Elma Izze da Silva, Daniela Santana Maia, Michele Pereira Netto, Joel Alves Lamounier, and Daniela da Silva Rocha. "Prevalência de anemia e determinantes da concentração de hemoglobina em gestantes." Cadernos Saúde Coletiva 26, no. 4 (2018): 384–90. http://dx.doi.org/10.1590/1414-462x201800040085.

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Resumo Introdução A anemia é caracterizada pela reduzida concentração de hemoglobina e, durante a gestação, está associada à maior morbimortalidade fetal e materna. Objetivo Avaliar a prevalência de anemia e os fatores determinantes da concentração de hemoglobina em gestantes. Método Estudo transversal com uma amostra de 328 gestantes atendidas nas unidades de saúde urbanas de Vitória da Conquista, na Bahia. Foram realizadas a aplicação de questionário, a avaliação antropométrica e a coleta de sangue por punção capilar para dosagem de hemoglobina em β-hemoglobinômetro portátil. Foram considera

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5

Huertas, Erasmo, Ricardo Sugajara, Walter Ventura, and Walter Castillo. "Velocidad sistólica máxima de la arteria cerebral media elevada en fetos sin anemia: ¿Falsos postivos?" Revista Peruana de Investigación Materno Perinatal 9, no. 2 (2020): 67–73. http://dx.doi.org/10.33421/inmp.2020205.

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La anemia fetal severa pude ser detectada intrautero a través de la medición de velocidad sistólica máxima de la Arteria Cerebral Media (VSmax-ACM). La tasa de falsos positivos de esta técnica de medición desafortunadamente es alta (34%) por lo que se sugiere el correlato clínico materno fetal y descartar condiciones que eleven falsamente la VPS antes de tomar alguna decisión respecto del diagnóstico de ser de anemia fetal. Presentamos un caso de un feto con VSmax-ACM alterado por encima de 1.5 MoM que nació con valores de hemoglobina normales.

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6

Huertas Tacchino, Erasmo. "ANEMIA FETAL Y MANEJO." Revista Peruana de Ginecología y Obstetricia 56, no. 4 (2015): 279–83. http://dx.doi.org/10.31403/rpgo.v56i211.

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La anemia fetal es la disminución de la concentración de hemoglobina (Hb) por debajo de 2 desviaciones estándar o <0,84 MoM con respecto a la media poblacional. Si bien es cierto que el estándar de oro para su diagnóstico es la medición de la Hb fetal mediante cordocentesis percutánea, el pico de velocidad sistólica de la arteria cerebral media (PVS - ACM) parece ser la mejor de las pruebas para el diagnóstico no invasivo de anemia fetal. Valores mayores o iguales a 1,55 MoM del PVS – ACM para la edad gestacional, se correlacionan con anemia fetal moderada a severa. Es importante enfatizar

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7

Mere, Juan, Luz Jefferson, Victoria Bao, and José Iza. "Retardo del crecimiento fetal." Revista Peruana de Ginecología y Obstetricia 46, no. 3 (2015): 249–57. http://dx.doi.org/10.31403/rpgo.v46i1421.

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OBJETIVO: Determinar la incidencia y características maternas, del parto y del neonato con retardo del crecimiento asimétrico y simétrico. MATERIAL Y MÉTODOS: Estudio descriptivo, retrospectivo de 396 nacidos vivos con retardo del crecimiento fetal (RCF). RESULTADOS: La incidencia anual fue 10,1%, siendo los asimétricos 242 (61,1%) y los simétricos 154 (38,9%). En las madres solteras fue mayor el asimétrico y en las convivientes, el simétrico. Hubo control prenatal adecuado en 71,7%. No hubo diferencias entre medidas antropométricos, ganancia de peso y hemoglobina materna entre los dos tipos.

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8

Vasquez Vasquez, Javier, Jesús Magallanes, Beder Camacho, et al. "Hemoglobina en gestantes y su asociación con características maternas y del recién nacido." Revista Peruana de Ginecología y Obstetricia 55, no. 3 (2015): 187–92. http://dx.doi.org/10.31403/rpgo.v55i291.

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Objetivo: Determinar la asociación del valor de la hemoglobina en la gestante y algunas características maternas y del recién nacido. Diseño: Estudio retrospectivo, observacional y correlacional. Institución: Hospital Regional de Loreto, Perú. Participantes: Gestantes y sus recién nacidos. Intervenciones: La muestra incluyó 320 gestantes, se utilizó el sistema aleatorio simple y se aplicó un instrumento elaborado por los investigadores. Principales medidas de resultados: Niveles de hemoglobina en la madre y su recién nacido. Resultados: La edad materna promedio fue 24 años, la mayoría con grad

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9

Mere, Juan, Hugo Contreras, Italo Gutiérrez, and José Rojas. "FACTORES DE RIESGO ASOCIADOS AL RETARDO DEL CRECIMIENTO FETAL." Revista Peruana de Ginecología y Obstetricia 45, no. 4 (2015): 274–79. http://dx.doi.org/10.31403/rpgo.v45i651.

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Objetivo: Determinar los factores de riesgo, asociados al retardo de crecimiento fetal Diseño y Método. Estudio caso control en el Servicio de ObstetriciaHospital Loayza, durante 1998. De 396 neonatos vivos con retardo de crecimiento, se tomó una muestra representativa (144). Se evaluó indicadores maternos y perinatales. Resultados: La edad materna, control prenatal, peso preconcepcional, talla materna, índice de masa corporal, ganancia de peso materno y la hemoglobina en el embarazo no mostraron diferencias significativas. Las patologías asociadas al retardo de crecimiento fetal (p < 0.05)

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10

Arango-Ochante, Pedro. "Anemia y su asociación con el peso del recién en gestantes adolescentes: ¿mito o realidad?" Revista Peruana de Investigación Materno Perinatal 7, no. 1 (2019): 35–50. http://dx.doi.org/10.33421/inmp.2018106.

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Objetivo. Determinar la relación existente entre la hemoglobina materna de gestantes adolescentes y el peso de los recién nacidos en el Instituto Nacional Materno Perinatal (INMP). Material y métodos. Transversalmente se analizaron 914 gestantes seleccionadas mediante criterios de inclusión y exclusión de 2729 partos de adolescentes atendidas en el INMP correspondiente al año 2017. Los datos se recogieron del registro de partos y las historias clínicas, las variables de interés fueron la hemoglobina materna y el peso del recién nacido. Resultados. De los 914 partos 299 madres (32%) presentaron

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11

Aste Salazar, Humberto, and Carlos Krumdieck B. "Diferenciación de hemoglobinas humanas en las grandes alturas." Revista Peruana de Ginecología y Obstetricia 17, no. 1 y 2 (2015): 79–102. http://dx.doi.org/10.31403/rpgo.v17i802.

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Un estudio se ha realizado sobre la posibilidad de que la hipoxia crónica, a la que el sujeto que nacen y viven en grandes altitudes son presentados, podría producir valores altos de hemoglobina fetal. Se estudiaron recién nacidos normales y sujetos adultos normales de Lima (150 metros sobre el nivel del mar), Oroya (3.726 mts.), Morocoha (4540 mt.) Y Ticlio (4.826 mts.). Para medir la cantidad de hemoglobina fetal se emplearon dos métodos: "proporción de alcalino - desnaturalización" y el "1 minuto residuos". A grandes altitdes la cantidad de Hb F caída entre el rango normal a nivel del mar.

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12

Barros, Sonia Maria Oliveira de, and Cláudia Aparecida Ribeiro Costa. "Consulta de enfermagem a gestantes com anemia ferropriva." Revista Latino-Americana de Enfermagem 7, no. 4 (1999): 105–11. http://dx.doi.org/10.1590/s0104-11691999000400014.

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Este trabalho teve como objetivos: construir um protocolo de levantamento de dados e diagnósticos de enfermagem, e conhecer os diagnósticos de enfermagem mais freqüentes. O protocolo construído foi aplicado em 52 consultas de enfermagem para as gestantes que apresentavam valores de hemoglobina menores que 11,0g/dl. Os diagnósticos de enfermagem mais freqüentes foram: nutrição alterada, risco para infecção, manutenção do lar prejudicada; déficit de conhecimento sobre a alimentação, risco para lesão fetal relacionada a diminuição da perfusão útero-placentária.; risco de não-comprometimento. A pa

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13

Silva, Lilianne B., Romélia P. Gonçalves, and Michele F. Martins. "Estudo da correlação entre os níveis de hemoglobina fetal e o prognóstico dos pacientes com anemia falciforme." Revista Brasileira de Hematologia e Hemoterapia 31, no. 6 (2009): 417–20. http://dx.doi.org/10.1590/s1516-84842009005000084.

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14

Monsalve Montoya, Rosa Edith, Rogelio Méndez Rodríguez, and Francisco Salcedo Ramos. "Caracterización de óbito fetal tardío en la clínica maternidad rafael calvo de cartagena de indias entre los años 2012 a 2013." Revista Ciencias Biomédicas 7, no. 1 (2020): 68–79. http://dx.doi.org/10.32997/rcb-2016-2933.

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Introducción: el óbito fetal tardío tiene connotaciones de salud pública y es indispensable su estudio, aun cuando no hace parte de los objetivos del milenio. El amplio subregistro, la gran variedad de clasificaciones, la dificultad en la unificación de conceptos han hecho que su búsqueda sea inespecífica. Los estudios sobre sus causas arrojan datos variables.Objetivo: describir las causas de óbito fetal tardío en las pacientes que consultaron a una clínica obstétricaMateriales y métodos: estudio descriptivo transversal. La población de estudio fueron 108 casos de pacientes que tuvieron parto

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15

Fonseca, L. M. D., A. D. Fonseca, and H. E. M. Fonseca. "RELATO DE CASO DE PACIENTE PORTADOR DE ANEMIA FALCIFORME COM PERSISTÊNCIA DA HEMOGLOBINA FETAL E PREDISPOSIÇÃO À TROMBOSE." Hematology, Transfusion and Cell Therapy 42 (November 2020): 97–98. http://dx.doi.org/10.1016/j.htct.2020.10.165.

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16

Ventura, Walter. "Estudio comparativo entre cesárea tipo Misgav Ladach y cesárea tipo Kerr." Anales de la Facultad de Medicina 70, no. 3 (2012): 199. http://dx.doi.org/10.15381/anales.v70i3.940.

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Introducción: La técnica de cesárea conocida como Misgav Ladach es una técnica minimalista y está siendo usada cada vez más en diferentes partes del mundo. Objetivos: Determinar los beneficios de la técnica Misgav Ladach, comparados con los de la cesárea clásica de Kerr. Diseño: Estudio retrospectivo, comparativo. Lugar: Hospital II EsSalud, Huamanga, Ayacucho. Participantes: Gestantes a término con feto único vivo, con indicación de cesárea. Intervenciones: Cesárea. Principales medidas de resultados: Tiempo operatorio, tiempo de extracción fetal, sangrado operatorio, uso de analgésico en el p

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17

Díaz, Hernando Flórez, Manuel Bernardo Alvarez Rico, and Astrid Gutiérrez De Gerardino. "Efecto de la gestación, parto y lactancia en la función hemática y hepática de vacas Holstein en condiciones tropicales." Corpoica Ciencia y Tecnología Agropecuaria 3, no. 1 (1999): 4. http://dx.doi.org/10.21930/rcta.vol3_num1_art:175.

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<p>En condiciones tropicales, los bovinos especializados en producción de leche presentan cambios en su fisiología ocasionados por el ambiente y los sistemas de manejo. La alteración de diversas funciones afecta la capacidad de expresión del potencial genético de producción. Esta investigación se realizó en la Sabana de Bogotá, Colombia, ubicada a 2547 msnm, temperatura media 13 <sup>0</sup>C, humedad relativa 80 % y precipitación pluvial 685 mm año. El objetivo del trabajo fue caracterizar los cambios en la función hemática y hepática de vacas lecheras en los períodos de ges

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18

Nogueira, Zeni Drubi, Carlos Mauricio Cardeal Mendes, Ney Boa-Sorte, Tatiana Amorim, and Maria Efigênia De Queiroz Leite. "Alterações antropométricas em crianças com doença falciforme." Revista de Ciências Médicas e Biológicas 13, no. 3 (2015): 393. http://dx.doi.org/10.9771/cmbio.v13i3.12924.

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<p class="MsoNormal" style="text-align: justify;"><strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: ">Introdução</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: ">: Anormalidades antropométricas são observadas em crianças com doença falciforme antes dos dois anos de vida, tendo como principais fatores relacionados o gasto energético em repouso elevado, a maior frequência de internações e a reduzida ingestão energética e de micronutrientes. <strong>Objetivo</strong>: Revisar os

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Junior, Carlos Alberto Rodrigues, Fellipe Camargo Ferreira Dias, Flávia Da Silva Oliveira, Gustavo Santos Sousa, Fábio Roberto Ruiz de Moraes, and Ana Carolina Batista de Souza Guedes. "Síndrome HELLP com descolamento placentário e óbito fetal: relato de caso." Revista de Patologia do Tocantins 4, no. 3 (2017): 34. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n3p34.

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The HELLP syndrome – defined as haemolysis, elevated liver enzymes and thrombocytopenia – consists of an advanced stage of preeclampsia (PE), which can affect 0.6% of pregnancies and 4-12% of patients with severe PE. Being responsible for elevated maternal and perinatal mortality rates, it can present with general malaise, epigastralgia, right hypochondrium pain, nausea and vomits, headache, scotomas, associated with hypertension and proteinuria. Woman, 19 years old, primigest, admitted with 29 weeks of gestational age presenting with arterial hypertension (160/120 mmHg), headache, scotomas, n

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Ragsdale, F. R., and R. L. Ingermann. "Biochemical bases for difference in oxygen affinity of maternal and fetal red blood cells of rattlesnakes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 3 (1993): R481—R486. http://dx.doi.org/10.1152/ajpregu.1993.264.3.r481.

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Pregnancy in Crotalus viridis oreganus is associated with an increase in the nucleoside triphosphate (NTP) concentration and a concomitant decrease in the oxygen affinity of the adult red blood cell. However, although the red blood cells of non-pregnant adults and fetuses have indistinguishable NTP concentrations, they have different oxygen affinities. Therefore, red blood cell NTP concentrations alone cannot account for the oxygen-affinity difference between fetal and maternal red blood cells. Hemoglobins from adult and fetal snakes had similar intrinsic oxygen affinities; however, adult hemo

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21

Wilber, Andrew, Arthur W. Nienhuis, and Derek A. Persons. "Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities." Blood 117, no. 15 (2011): 3945–53. http://dx.doi.org/10.1182/blood-2010-11-316893.

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Abstract In humans, embryonic, fetal, and adult hemoglobins are sequentially expressed in developing erythroblasts during ontogeny. For the past 40 years, this process has been the subject of intensive study because of its value to enlighten the biology of developmental gene regulation and because fetal hemoglobin can significantly ameliorate the clinical manifestations of both sickle cell disease and β-thalassemia. Understanding the normal process of loss of fetal globin expression and activation of adult globin expression could potentially lead to new therapeutic approaches for these hemoglo

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Baranowska-Jaźwiecka, Anna Iza, Beata Mianowska, Wojciech Fendler, Agnieszka Pomykała, and Wojciech Młynarski. "Fetal hemoglobin and hemoglobin A1c level among pediatric patients with type 1 diabetes." Pediatric Endocrinology Diabetes and Metabolism 22, no. 2 (2016): 48–53. http://dx.doi.org/10.18544/pedm-22.02.0050.

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23

Little, Randie R., and William L. Roberts. "A Review of Variant Hemoglobins Interfering with Hemoglobin A1c Measurement." Journal of Diabetes Science and Technology 3, no. 3 (2009): 446–51. http://dx.doi.org/10.1177/193229680900300307.

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Hemoglobin A1c (HbA1c) is used routinely to monitor long-term glycemic control in people with diabetes mellitus, as HbA1c is related directly to risks for diabetic complications. The accuracy of HbA1c methods can be affected adversely by the presence of hemoglobin (Hb) variants or elevated levels of fetal hemoglobin (HbF). The effect of each variant or elevated HbF must be examined with each specific method. The most common Hb variants worldwide are HbS, HbE, HbC, and HbD. All of these Hb variants have single amino acid substitutions in the Hb β chain. HbF is the major hemoglobin during intrau

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Guia, Luísa de Carvalho Mares, Emille Meira Lessa, Tamara Lacerda Mesquita, et al. "Frequência de anemia: uma comparação entre gestantes adolescentes e adultas." Revista Eletrônica Acervo Saúde 13, no. 7 (2021): e8417. http://dx.doi.org/10.25248/reas.e8417.2021.

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Objetivo: Avaliar a frequência de anemia em gestantes adolescentes e adultas. Métodos: Tratou-se de uma coorte histórica que estudou dados de 1414 gestantes, sendo 293 adolescentes e 1121 adultas. Resultados: A anemia ferropriva foi identificada em 98% e a macrocítica em 2% dos casos. A média de hemoglobina nas gestantes adolescentes foi de 11,7 (±1,37) no primeiro, 11,30 (±1,09) no segundo e 11,50 (±1,52) no terceiro trimestre. Já nas adultas, observou-se 12,10 (±1,25),11,50 (±1,12) e 11,80 (±1,40) respectivamente. A comparação entre os dois grupos revelou p <0,001 para o primeiro trimestr

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Montenegro Jr, Renan M., Glória M. F. G. Paccola, Cláudia M. Faria, et al. "Evolução materno-fetal de gestantes diabéticas seguidas no HC-FMRP-USP no período de 1992-1999." Arquivos Brasileiros de Endocrinologia & Metabologia 45, no. 5 (2001): 467–74. http://dx.doi.org/10.1590/s0004-27302001000500010.

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Este estudo teve por objetivo avaliar a freqüência de complicações materno-fetais, tipo de parto e controle metabólico das gestantes diabéticas atendidas no HCFMRP-USP, entre 1992 e 1999. Foram estudadas 261 pacientes, das quais 44 (16,3%) tinham diabetes mellitus tipo 1 (DM1), 82 (30,5%) diabetes tipo 2 (DM2) e 143 (53,2%) diabetes gestacional (DMG). Observou-se uma freqüência elevada de obesidade previamente à gestação nas pacientes com DMG (47,6%) e DM2 (65,9%) e também de HAS nesse último grupo (46,3%). Apesar do início tardio, houve no decorrer do seguimento melhora do controle metabólico

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Wilkening, R. B., R. D. Molina, and G. Meschia. "Placental oxygen transport in sheep with different hemoglobin types." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 254, no. 4 (1988): R585—R589. http://dx.doi.org/10.1152/ajpregu.1988.254.4.r585.

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To study the effect of genetic differences in the maternal oxyhemoglobin dissociation curve on fetal O2 supply, we compared eight pregnant ewes homozygous for high O2 affinity hemoglobin (A) with eight pregnant ewes homozygous for low O2 affinity hemoglobin (B). Each ewe carried a single fetus. Fetal weights were not significantly different (A, 3,000 +/- 170 g; B, 3,070 +/- 270 g). The A ewes had significantly higher arterial O2 saturation (95 vs. 89.4%), uterine blood flow per kilogram of fetus (464 vs. 374 ml/min), uterine venous O2 saturation (78.1 vs. 67.5%), and placental-to-fetal weight

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Cienfuegos Solís, Héctor, Misael Lindo, Cecilia Zea, and Jorge Fuentes. "Técnica Pelosi de operación cesárea. Estudio clínico comparativo con la técnica convencional." Revista Peruana de Ginecología y Obstetricia 51, no. 2 (2015): 105–9. http://dx.doi.org/10.31403/rpgo.v51i403.

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OBJETIVO: Comparar las características y morbilidad asociadas a la técnica convencional de cesárea y la técnica Pelosi de cesárea. DISEÑO: Estudio retrospectivo, comparativo, descriptivo. LUGAR: Servicio de Obstetricia del Hospital I "Uldarico Rocca Fernández" (EsSalud). MATERIAL Y MÉTODOS: Se revisó 162 historias clínicas de pacientes que fueron sometidas a cesárea entre los años 2001 y 2002; de las cuales 81 fueron realizadas con la técnica convencional y otras 81 con la técnica Pelosi. Se determinó el tiempo operatorio, presencia y tipo de complicaciones, pérdida sanguínea, tiempo de reinic

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Bergstrom, Richard W. "Fetal Hemoglobin Alters Hemoglobin A_1c Measurements." Annals of Internal Medicine 115, no. 8 (1991): 656. http://dx.doi.org/10.7326/0003-4819-115-8-656_1.

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29

Wong, PM, SW Chung, SM Reicheld, and DH Chui. "Hemoglobin switching during murine embryonic development: evidence for two populations of embryonic erythropoietic progenitor cells." Blood 67, no. 3 (1986): 716–21. http://dx.doi.org/10.1182/blood.v67.3.716.716.

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Abstract Explants of normal mouse embryonic tissues and disaggregated embryonic single cells were cultured in vitro to study the erythropoietic progenitor cells present during embryonic development. The results indicate that there are two populations of erythropoietic progenitor cells committed to different hemoglobin synthetic programs. These progenitor cells are present at an early gestational stage prior to the formation of the fetal hepatic primordium. One population of progenitors can be stimulated by erythropoietin alone to form usually small erythroid colonies after culture for six days

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Wong, PM, SW Chung, SM Reicheld, and DH Chui. "Hemoglobin switching during murine embryonic development: evidence for two populations of embryonic erythropoietic progenitor cells." Blood 67, no. 3 (1986): 716–21. http://dx.doi.org/10.1182/blood.v67.3.716.bloodjournal673716.

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Explants of normal mouse embryonic tissues and disaggregated embryonic single cells were cultured in vitro to study the erythropoietic progenitor cells present during embryonic development. The results indicate that there are two populations of erythropoietic progenitor cells committed to different hemoglobin synthetic programs. These progenitor cells are present at an early gestational stage prior to the formation of the fetal hepatic primordium. One population of progenitors can be stimulated by erythropoietin alone to form usually small erythroid colonies after culture for six days in vitro

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31

Grossman, David M. "Fetal Hemoglobin and the Glycosylated Hemoglobin Assay." Annals of Internal Medicine 120, no. 6 (1994): 524. http://dx.doi.org/10.7326/0003-4819-120-6-199403150-00022.

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32

Hansson, Stefan R., Magnus Gram, and Bo Åkerström. "Fetal hemoglobin in preeclampsia." Current Opinion in Obstetrics and Gynecology 25, no. 6 (2013): 448–55. http://dx.doi.org/10.1097/gco.0000000000000022.

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33

Little, JA, NJ Dempsey, M. Tuchman, and GD Ginder. "Metabolic persistence of fetal hemoglobin." Blood 85, no. 7 (1995): 1712–18. http://dx.doi.org/10.1182/blood.v85.7.1712.bloodjournal8571712.

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Hereditary persistence of fetal hemoglobin (HPFH) has typically been ascribed to mutations in the beta-globin gene cluster. Pharmacologic agents, including the short-chain fatty acid butyrate, have been shown to upregulate fetal and embryonic globin gene expression. In this report we investigate the possibility that metabolic derangements characterized by an inability to metabolize another short-chain fatty acid, propionate, could be associated with a persistence of fetal hemoglobin unrelated to alterations in the beta-globin cluster. Embryonic globin gene upregulation in a murine adult erythr

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34

Miller, BA, M. Salameh, M. Ahmed, et al. "High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined." Blood 67, no. 5 (1986): 1404–10. http://dx.doi.org/10.1182/blood.v67.5.1404.1404.

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Abstract Homozygous sickle cell disease in the eastern province of Saudi Arabia is clinically mild. Circulating fetal hemoglobin levels of 16.0 +/- 7.4% were found in these anemic patients, but only 1.09 +/- 0.97% in their sickle trait parents. To determine whether these sickle cell anemia patients inherit an increased capacity to synthesize fetal hemoglobin, a radioimmunoassay of fetal and adult hemoglobin was performed on erythroid progenitor (BFU-E)-derived erythroblasts from Saudi Arabian sickle cell patients and their parents. Mean fetal hemoglobin content per BFU-E-derived erythroblast f

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35

Miller, BA, M. Salameh, M. Ahmed, et al. "High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined." Blood 67, no. 5 (1986): 1404–10. http://dx.doi.org/10.1182/blood.v67.5.1404.bloodjournal6751404.

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Homozygous sickle cell disease in the eastern province of Saudi Arabia is clinically mild. Circulating fetal hemoglobin levels of 16.0 +/- 7.4% were found in these anemic patients, but only 1.09 +/- 0.97% in their sickle trait parents. To determine whether these sickle cell anemia patients inherit an increased capacity to synthesize fetal hemoglobin, a radioimmunoassay of fetal and adult hemoglobin was performed on erythroid progenitor (BFU-E)-derived erythroblasts from Saudi Arabian sickle cell patients and their parents. Mean fetal hemoglobin content per BFU-E-derived erythroblast from Saudi

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36

Reis, Zilma Silveira Nogueira, Gabriel Costa Osanan, Tiago Lanfernini Ricardo Coelho, Cezar Alencar De Lima Rezende, Henrique Vitor Leite, and Antônio Carlos Vieira Cabral. "Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values." Anemia 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/351258.

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Objectives. To compare current criteria for severe fetal anemia diagnosis.Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia. Concordance among the diagnostic criteria for severe fetal anemia, hemoglobin deficit >7 g/dL, hemoglobin deficit ≥5 g/dL, and hemoglobin concentration <0.55 MoM, was analyzed using Cohen’s Kappa index. Perinatal mortality, fetal hydrops, and fetal acidosis were used to discuss discordances.Results. There was fair concordance among the three criteria analyzed: 0.80 (Kappa index, IC 95%: 0.67 to 0.93) w

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37

Nishino, Tamon, Junko Yaegashi, Toya Ohashi, Yoshitsugu Matsumoto, and Eto Yoshikatsu. "The Course of Plasmodium.yoelii Infection in Hereditary Persistence of Fetal Hemoglobin." Blood 106, no. 11 (2005): 3728. http://dx.doi.org/10.1182/blood.v106.11.3728.3728.

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Abstract Malaria, caused by plasmodium species has great impact on human generations. Each year 300–500 million of people are diagnosed and 1 million die of the disease. Malaria probably become endemic about 10,000 years ago and it has affected human genome by strong selective pressure. Several human genetic diseases are thought to be the outcome of this pressure. Our current research is focused on understanding natural host defense mechanism of this disease, especially effect to human fetal hemoglobin expression to plasmodium species. Other investigator indicated growth of Plasmodium falcipar

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38

Whitham, Megan, Jayson Pagaduan, Steven L. Clark, et al. "Validation of the Siggaard–Andersen Acid–Base Nomogram for Hemoglobin F: Implications for Fetal Cord Blood Gas Analysis." American Journal of Perinatology 36, no. 14 (2019): 1481–84. http://dx.doi.org/10.1055/s-0039-1677800.

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Objective The calculation of HCO3 and base excess in current blood gas analysis is based on the Siggaard–Andersen equation. One of the constants in this equation is dependent on the known buffering capacity of hemoglobin A. We sought to investigate differences in buffering capacity between adult hemoglobin A and fetal hemoglobin F as a potential explanation for the observed poor correlation between calculated base excess in umbilical cord blood and newborn outcomes. Such differences would influence a key constant in the Van Slyke/Siggaard–Andersen equation used to calculate HCO3 and base exces

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39

Sharma, DharmeshChandra, Sachin Singhal, Poonam Woike, Sunita Rai, Mahesh Yadav, and Rajesh Gaur. "Hereditary persistence of fetal hemoglobin." Asian Journal of Transfusion Science 14, no. 2 (2020): 185. http://dx.doi.org/10.4103/ajts.ajts_71_16.

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40

Koskinen, L. K., J. T. Lahtela, and T. A. Koivula. "Fetal Hemoglobin in Diabetic Patients." Diabetes Care 17, no. 8 (1994): 828–31. http://dx.doi.org/10.2337/diacare.17.8.828.

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41

Oneal, Patricia A., Nicole M. Gantt, Joseph D. Schwartz, et al. "Fetal hemoglobin silencing in humans." Blood 108, no. 6 (2006): 2081–86. http://dx.doi.org/10.1182/blood-2006-04-015859.

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Abstract Interruption of the normal fetal-to-adult transition of hemoglobin expression should largely ameliorate sickle cell and beta-thalassemia syndromes. Achievement of this clinical goal requires a robust understanding of gamma-globin gene and protein silencing during human development. For this purpose, age-related changes in globin phenotypes of circulating human erythroid cells were examined from 5 umbilical cords, 99 infants, and 5 adult donors. Unexpectedly, an average of 95% of the cord blood erythrocytes and reticulocytes expressed HbA and the adult beta-globin gene, as well as HbF

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42

STEINBERG, MARTIN H., and GRIFFIN P. RODGERS. "Pharmacologic Modulation of Fetal Hemoglobin." Medicine 80, no. 5 (2001): 328–44. http://dx.doi.org/10.1097/00005792-200109000-00007.

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43

DOVER, GEORGE J. "Pharmacologic Manipulation of Fetal Hemoglobin." Annals of the New York Academy of Sciences 612, no. 1 Sixth Cooley' (1990): 184–90. http://dx.doi.org/10.1111/j.1749-6632.1990.tb24305.x.

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44

Rochette, J., J. E. Craig, S. L. Thein, and J. Rochette. "Fetal hemoglobin levels in adults." Blood Reviews 8, no. 4 (1994): 213–24. http://dx.doi.org/10.1016/0268-960x(94)90109-0.

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45

Miller, BA, SP Perrine, G. Antognetti, et al. "Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells." Blood 69, no. 6 (1987): 1674–81. http://dx.doi.org/10.1182/blood.v69.6.1674.1674.

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Abstract Interferons have the ability to enhance or diminish the expression of specific genes and have been shown to affect the proliferation of certain cells. Here, the effect of gamma-interferon on fetal hemoglobin synthesis by purified cord blood, fetal liver, and adult bone marrow erythroid progenitors was studied with a radioligand assay to measure hemoglobin production by BFU-E-derived erythroblasts. Coculture with recombinant gamma-interferon resulted in a significant and dose- dependent decrease in fetal hemoglobin production by neonatal and adult, but not fetal, BFU-E-derived erythrob

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46

Miller, BA, SP Perrine, G. Antognetti, et al. "Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells." Blood 69, no. 6 (1987): 1674–81. http://dx.doi.org/10.1182/blood.v69.6.1674.bloodjournal6961674.

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Interferons have the ability to enhance or diminish the expression of specific genes and have been shown to affect the proliferation of certain cells. Here, the effect of gamma-interferon on fetal hemoglobin synthesis by purified cord blood, fetal liver, and adult bone marrow erythroid progenitors was studied with a radioligand assay to measure hemoglobin production by BFU-E-derived erythroblasts. Coculture with recombinant gamma-interferon resulted in a significant and dose- dependent decrease in fetal hemoglobin production by neonatal and adult, but not fetal, BFU-E-derived erythroblasts. Ac

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47

Rohlfing, Curt L., Shawn M. Connolly, Jack D. England, et al. "The Effect of Elevated Fetal Hemoglobin on Hemoglobin A1cResults." American Journal of Clinical Pathology 129, no. 5 (2008): 811–14. http://dx.doi.org/10.1309/yfvtud0ghjf7d16h.

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48

Krauss, J. S., M. H. Jonah, L. D. Devoe та C. G. Pantazis. "Failure of Microchromatographic Measurement of Fetal Hemoglobin in β0 Thalassemia-Hereditary Persistence of Fetal Hemoglobin". Clinical Chemistry 38, № 11 (1992): 2325–27. http://dx.doi.org/10.1093/clinchem/38.11.2325.

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Abstract We report microchromatographic measurement of fetal hemoglobin (HbF) proportions in a 36-year-old African-American multigravida woman. At 34 weeks she delivered a 630-g male infant who subsequently did well. Hemoglobin electrophoresis of the hemolysate revealed nearly 100% HbF without HbA, an extremely unusual naturally occurring sample. Family studies revealed a combination of hereditary persistence of fetal hemoglobin (HPFH) and beta zero-thalassemia minor. Southern blot technique confirmed heterozygous alpha 2 thalassemia and HPFH but failed to identify the beta thalassemic lesion.

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49

Archer, Natasha M., Nicole Petersen, and Manoj T. Duraisingh. "Fetal hemoglobin does not inhibit Plasmodium falciparum growth." Blood Advances 3, no. 14 (2019): 2149–52. http://dx.doi.org/10.1182/bloodadvances.2019000399.

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Key Points P falciparum growth is not inhibited in either cord or heterozygote hereditary persistence of fetal hemoglobin erythrocytes. P falciparum growth in fetal hemoglobin erythrocytes is oxygen independent.

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50

Miller, BA, O. Platt, S. Hope, G. Dover, and DG Nathan. "Influence of hydroxyurea on fetal hemoglobin production in vitro." Blood 70, no. 6 (1987): 1824–29. http://dx.doi.org/10.1182/blood.v70.6.1824.1824.

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Abstract Cytotoxic drugs increase circulating fetal hemoglobin levels. We examined the mechanism by measuring the fetal hemoglobin produced per BFU-E-derived erythroblast following hydroxyurea treatment in vivo and in vitro. Treatment of four sickle cell patients increased the percentage of circulating F reticulocytes. The frequencies of bone marrow or peripheral blood BFU-E or CFU-E-derived colonies and their fetal hemoglobin content were unaffected. In all cases, the number of erythroid cells/progenitor-derived colony increased. To explore further the effect of hydroxyurea on fetal hemoglobi

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