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Journal articles on the topic 'Hemolytic Disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Dorrah, Moataza, Chaima Bensaoud, Amr A. Mohamed, Daniel Sojka, Taha T. M. Bassal, and Michail Kotsyfakis. "Comparison of the hemolysis machinery in two evolutionarily distant blood-feeding arthropod vectors of human diseases." PLOS Neglected Tropical Diseases 15, no. 2 (2021): e0009151. http://dx.doi.org/10.1371/journal.pntd.0009151.

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Host blood protein digestion plays a pivotal role in the ontogeny and reproduction of hematophagous vectors. The gut of hematophagous arthropods stores and slowly digests host blood and represents the primary gateway for transmitted pathogens. The initial step in blood degradation is induced lysis of host red blood cells (hemolysis), which releases hemoglobin for subsequent processing by digestive proteolytic enzymes. The activity cycles and characteristics of hemolysis in vectors are poorly understood. Hence, we investigated hemolysis in two evolutionarily distant blood-feeding arthropods: Th

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2

Udou, Takezo. "Extracellular hemolytic activity in rapidly growing mycobacteria." Canadian Journal of Microbiology 40, no. 4 (1994): 318–21. http://dx.doi.org/10.1139/m94-052.

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Little is known about virulence factors associated with rapidly growing mycobacteria. We evaluated 42 clinical isolates of Mycobacterium fortuitum and Mycobacterium chelonae and 4 reference strains of Mycobacterium smegmatis for the production of hemolysin (or hemolytic substance) as a possible contributor to the pathogenesis of disease caused by these organisms. All the strains tested possessed extracellular hemolytic activity that was stable after heating and proteinase treatment, and the active substance had a molecular weight less than 10 000. The activity accumulated in culture medium dur

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3

Gallagher, Patrick G. "Diagnosis and management of rare congenital nonimmune hemolytic disease." Hematology 2015, no. 1 (2015): 392–99. http://dx.doi.org/10.1182/asheducation-2015.1.392.

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AbstractRare, congenital nonimmune hemolytic disorders of the erythrocyte, although uncommon, are important causes of anemia in the child and adult. These are a heterogeneous group of diseases that disrupt normal erythrocyte structure and function in varying ways. Predominant are abnormalities of hemoglobin stability, defects of erythrocyte metabolism, and disorders of erythrocyte hydration. Unstable hemoglobinopathies may lead to chronic or episodic hemolysis. Perturbation of critical enzymes of the Embden–Meyerhof pathway lead to altered erythrocyte metabolism and chronic hemolysis. Disorder

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4

Merle, Nicolas S., Romain Paule, Juliette Leon, et al. "P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner." Proceedings of the National Academy of Sciences 116, no. 13 (2019): 6280–85. http://dx.doi.org/10.1073/pnas.1814797116.

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Hemolytic diseases are frequently linked to multiorgan failure subsequent to vascular damage. Deciphering the mechanisms leading to organ injury upon hemolytic event could bring out therapeutic approaches. Complement system activation occurs in hemolytic disorders, such as sickle cell disease, but the pathological relevance and the acquisition of a complement-activating phenotype during hemolysis remain unclear. Here we found that intravascular hemolysis, induced by injection of phenylhydrazine, resulted in increased alanine aminotransferase plasma levels and NGAL expression. This liver damage

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5

Brodsky, Robert A. "Complement in hemolytic anemia." Hematology 2015, no. 1 (2015): 385–91. http://dx.doi.org/10.1182/asheducation.v2015.1.385.3917876.

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Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations that lead to activation of the alternative pathway of complement. For optimal therapy, it is critical, but often difficult, to distinguish aHUS from other TMAs, such as thrombotic thromb

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6

Louachama, Ouidad, Aicha Bourrahouat, Ibtissam Khattou, Imane Ait Sab, and Mohamed Sbihi. "Recurrent Hemolytic Anemia as an Inaugural Manifestation of Wilson Disease in Children: A Case Report." Open Pediatric Medicine Journal 9, no. 1 (2019): 5–6. http://dx.doi.org/10.2174/1874309901909010005.

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Wilson disease (WD) is a disorder of copper metabolism. Liver and brain disorders are the main presentations, hemolytic anemia in WD is a rare inaugural symptom. We report a case of a child who developed recurrent hemolytic anemia associated with liver failure in the second hemolysis episode as the first manifestation of WD. Wilson's disease is not exceptional in children with hemolytic anemia, but another differential diagnosis must be excluded.

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7

Brodsky, Robert A. "Complement in hemolytic anemia." Blood 126, no. 22 (2015): 2459–65. http://dx.doi.org/10.1182/blood-2015-06-640995.

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Abstract Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations that lead to activation of the alternative pathway of complement. For optimal therapy, it is critical, but often difficult, to distinguish aHUS from other TMAs, such as thrombot

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8

Brodsky, Robert A. "Complement in hemolytic anemia." Hematology 2015, no. 1 (2015): 385–91. http://dx.doi.org/10.1182/asheducation-2015.1.385.

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Abstract Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations that lead to activation of the alternative pathway of complement. For optimal therapy, it is critical, but often difficult, to distinguish aHUS from other TMAs, such as thrombot

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9

Nouraie, Mehdi, Caterina Minniti, Craig Sable, et al. "Association of Hemolysis with Clinical Manifestations of Sickle Cell Disease." Blood 112, no. 11 (2008): 2482. http://dx.doi.org/10.1182/blood.v112.11.2482.2482.

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Abstract Background: Sickle cell disease shares common complications such as vasculopathy and organ dysfunction involving the heart, the lungs, the liver and the kidneys with other hemolytic conditions. We hypothesized that a hemolytic vasculopathy may underlie some of these complications. Distinguishing whether a complication is due to hemolysis or to the degree of anemia has been a challenge. Methods: A prospective, multicenter study of 310 children and adolescents with sickle cell disease in steady state was conducted. The associations of measures of hemolysis and of hemoglobin concentratio

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10

Hsu, Tsungda, David L. Hutto, F. Chris Minion, Richard L. Zuerner, and Michael J. Wannemuehler. "Cloning of a Beta-Hemolysin Gene ofBrachyspira (Serpulina) hyodysenteriaeand Its Expression in Escherichia coli." Infection and Immunity 69, no. 2 (2001): 706–11. http://dx.doi.org/10.1128/iai.69.2.706-711.2001.

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ABSTRACT Brachyspira (Serpulina)hyodysenteriae induces a mucohemorrhagic diarrheal disease in pigs. The production of a beta-hemolysin has been considered a major virulence attribute of this organism. Previous reports have failed to correlate a specific cloned gene sequence with a purified beta-hemolytic protein sequence. Thus, questions still remain concerning the structural gene sequence of the hemolysin. To answer this question unequivocally, the beta-hemolytic toxin was purified from extracts of log-phase spirochetes, and the N-terminal amino acid sequence was determined (K-D-V-V-A-N-Q-L-N

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11

Rivas, Amable J., Miguel Balado, Manuel L. Lemos, and Carlos R. Osorio. "The Photobacterium damselae subsp. damselae Hemolysins Damselysin and HlyA Are Encoded within a New Virulence Plasmid." Infection and Immunity 79, no. 11 (2011): 4617–27. http://dx.doi.org/10.1128/iai.05436-11.

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ABSTRACTPhotobacterium damselaesubsp.damselae(formerlyVibrio damsela) is a marine bacterium that causes infections and fatal disease in a wide range of marine animals and in humans. Highly hemolytic strains produce damselysin (Dly), a cytolysin encoded by thedlygene that is lethal for mice and has hemolytic activity. We found that Dly is encoded in the highly hemolytic strain RM-71 within a 153,429-bp conjugative plasmid that we dubbed pPHDD1. In addition to Dly, pPHDD1 also encodes a homologue of the pore-forming toxin HlyA. We found a direct correlation between presence of pPHDD1 and a stron

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12

Novelli, Enrico M., Mariana E. Hildesheim, Caterina Rosano, et al. "Elevated Pulse Pressure Is Associated with Hemolysis, Proteinuria and Chronic Kidney Disease in Sickle Cell Disease." Blood 124, no. 21 (2014): 2711. http://dx.doi.org/10.1182/blood.v124.21.2711.2711.

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Abstract A seeming paradox of sickle cell disease is that patients do not suffer from a high prevalence of systemic hypertension in spite of endothelial dysfunction, chronic inflammation and vasculopathy. However, some patients do develop systolic hypertension and increased pulse pressure, an increasingly recognized major cardiovascular risk factor in other populations. Hence, we hypothesized that pulse pressure, unlike other blood pressure parameters, is independently associated with markers of hemolytic anemia and cardiovascular risk in sickle cell disease. We analyzed the correlates of puls

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13

Jones, D. R. E., T. J. Gruffydd-Jones, C. R. Stokes, and F. J. Bourne. "Use of a direct enzyme-linked antiglobulin test for laboratory diagnosis of immune-mediated hemolytic anemia in dogs." American Journal of Veterinary Research 53, no. 4 (1992): 457–65. http://dx.doi.org/10.2460/ajvr.1991.53.04.457.

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Summary Detection of autoantibody, complement, or both bound to rbc is an essential requirement for unequivocal diagnosis of immune-mediated hemolytic anemia in dogs. An enzyme-linked antiglobulin test was adapted for laboratory diagnosis of this disease. The refinement and routine use of this assay have allowed further observation of the pathogenesis of the disease process. In particular, degree of hemolysis can be related to the degree of rbc sensitization associated with primary immune-mediated hemolytic anemia, and this correlation is highest for IgG autoantibody. Results indicate that aut

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14

Gertz, Morie A. "Cold Hemolytic Syndrome." Hematology 2006, no. 1 (2006): 19–23. http://dx.doi.org/10.1182/asheducation-2006.1.19.

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Abstract In most cases, immune-mediated hemolysis occurs extravascularly and is associated with IgG antibodies on the surface of red cells. Rare syndromes include IgG antibodies that cause direct intravascular hemolysis, such as paroxysmal cold hemoglobinuria. Also rare are extravascular hemolytic syndromes caused by IgM polyclonal or monoclonal antibodies that demonstrate red cell agglutination at 3°C, so-called cold antibodies. Because cold agglutinin disease has a high association with several lymphoproliferative disorders and IgM monoclonal gammopathies, its management differs significantl

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15

Krivosheina, E. L., N. Yu Koval, E. N. Egorova, et al. "Family case hemolytic anemia due to abnormal unstable hemoglobin with low oxygen affinity (Hb Cheverly)." Pediatric Hematology/Oncology and Immunopathology 18, no. 3 (2019): 62–69. http://dx.doi.org/10.24287/1726-1708-2019-18-3-62-69.

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Hereditary hemolytic anemia caused by unstable hemoglobin is a rare pathology, characterized by variability of clinical manifestations. This disease is characterized by the hemolytic crises, which are frequently associated with infections or taking drugs that cause hemolysis. Age of debut depends on which of the globin chains mutation occurs. Among these diseases, hemolytic anemia associated with the presence of a structurally abnormal unstable hemoglobin with low oxygen affinity in the erythrocytes is a special group. With this type of abnormal hemoglobin, pulse oximetry demonstrates falsely

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16

Nsiah, K., V. P. Dzogbefia, D. Ansong, A. Osei Akoto, H. Boateng, and D. Ocloo. "Pattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease." Clinical medicine. Blood disorders 4 (January 2011): CMBD.S3969. http://dx.doi.org/10.4137/cmbd.s3969.

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Background Elevated aminotransferase levels are commonly associated with compromised hepatic integrity from various insults. In sickle cell disease, aspartate transaminase (AST) is also released via intravascular hemolysis. This study was done to determine the pattern of changes in AST and alanine transaminase (ALT), in particular the AST:ALT ratio, and to relate these to the hemolytic state, which we consider to be more important than hepatic and cardiac dysfunction in some individuals with sickle cell disease. Methods Serum aminotransferase levels were measured in 330 subjects with sickle ce

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17

Mutiawati, Vivi Keumala. "HEMOLYTIC DISEASE OF THE NEWBORN." Jurnal Kedokteran Syiah Kuala 18, no. 2 (2018): 104–9. http://dx.doi.org/10.24815/jks.v18i2.18001.

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Abstrak. Pemahaman penyakit hemolitik pada bayi baru lahir telah berubah selama beberapa dekade terakhir. Penyakit hemolitik akibat inkompatibilitas ABO dan aloantibodi lainnya kini muncul sebagai penyebab utama. Banyak negara telah mengidentifikasi aloantibodi selain anti D sebagai penyebab penyakit hemolitik dengan gejala klinis sedang sampai dengan berat. Prevalensi dan frekuensi populasi antibodi anti-A dan anti B dari golongan darah ABO berguna dalam memprediksi perkiraan anak yang lahir oleh wanita golongan darah O yang menikahi suami golongan darah bukan O yang berisiko menjadi ABO HDN.

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18

Naomi, Carene, I. Wayan Suardana, and I. Nyoman Suarsana. "Isolated Hemolysis Profile of Streptococcus Sp. Isolation Result from Swine’s Tonsil In Slaughter House at Punggul and Bongkasa Village." Journal of Veterinary and Animal Sciences 2, no. 2 (2019): 46. http://dx.doi.org/10.24843/jvas.2019.v02.i02.p01.

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Streptococcus is a Gram-positive coccus from the family Streptococcaceae that can be found normally in some healthy animal but can cause a disease as well. The purpose of this research is to know the hemolysis profile from pig’s tonsil swab isolated from the traditional pig slaughterhouse at Punggul Village and Bongkasa Village that can be divided into three hemolytic profile; alpha-hemolytic, beta hemolytic, and gamma hemolytic, to know the pathogenicity. This research is divided into several steps, such as; isolating the swab, Gram test, catalase test, oxidase test, and hemolysis test on She

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19

Milton, Jacqueline N., Paola Sebastiani, Yingze Zhang, et al. "Clinical and Genetic Variability of Red Blood Cell Hemolysis in Sickle Cell Anemia." Blood 118, no. 21 (2011): 1077. http://dx.doi.org/10.1182/blood.v118.21.1077.1077.

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Abstract Abstract 1077 Intravascular hemolysis is an important pathological mechanism underlying some complications of sickle cell disease and other hemolytic anemias. Hemolysis contributes to endothelial dysfunction, pulmonary and systemic vasculopathy, and platelet and hemostatic activation via nitric oxide catabolism by plasma hemoglobin and arginine catabolism by red blood cell arginase. Little is known about the molecular mechanisms of hemolysis and how the propensity of erythrocytes to hemolyze is modulated. Hemoglobin F concentration and the presence of ∝ thalassemia affect the level of

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20

Jäger, Ulrich, Shirley D’Sa, Christian Schörgenhofer, et al. "Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial." Blood 133, no. 9 (2019): 893–901. http://dx.doi.org/10.1182/blood-2018-06-856930.

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Abstract Cold agglutinin disease is a difficult-to-treat autoimmune hemolytic anemia in which immunoglobulin M antibodies bind to erythrocytes and fix complement, resulting in predominantly extravascular hemolysis. This trial tested the hypothesis that the anti-C1s antibody sutimlimab would ameliorate hemolytic anemia. Ten patients with cold agglutinin disease participated in the phase 1b component of a first-in-human trial. Patients received a test dose of 10-mg/kg sutimlimab followed by a full dose of 60 mg/kg 1 to 4 days later and 3 additional weekly doses of 60 mg/kg. All infusions were we

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21

Yenerel, Mustafa Nuri, Petra Muus, Amanda Wilson, and Jeff Szer. "Patients with Paroxysmal Nocturnal Hemoglobinuria and Hemolysis Demonstrate More Frequent Disease-Related Features Than Those without Hemolysis, but Similar Proportions Experience Thromboembolism." Blood 126, no. 23 (2015): 3339. http://dx.doi.org/10.1182/blood.v126.23.3339.3339.

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Abstract Introduction: Patients with paroxysmal nocturnal hemoglobinuria (PNH) suffer high morbidity and mortality, however, data characterizing these patients by hemolytic status are unavailable. The objective of this analysis is to describe disease characteristics in patients with PNH by the presence of hemolysis. Methods: The International PNH Registry is a prospective, observational study of patients with a PNH clone of 0.01-100%. At enrollment, historic data are collected from disease start, prospectively and semi-annually thereafter. Patients enrolled on or before 8 April 2015 were eligi

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Kok, Victor C., Chien-Kuan Lee, Jorng-Tzong Horng, Che-Chen Lin, and Fung-Chang Sung. "Reappraisal of the Etiology of Extracorpuscular Non-Autoimmune Acquired Hemolytic Anemia in 2657 Hospitalized Patients with Non-Neoplastic Disease." Clinical Medicine Insights: Pathology 7 (January 2014): CPath.S14875. http://dx.doi.org/10.4137/cpath.s14875.

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Introduction Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real-world etiology or mechanisms of the non-hereditary non-AIHA from a nationwide population-based administrative claim database in Taiwan. Patients and Methods The National Health Insurance Research Databa

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23

Brake, Sami. "Hemolytic Anemia Associated with Fulminant Hepatitis in Wilson's Disease: Diagnosis and Management." Blood 114, no. 22 (2009): 5088. http://dx.doi.org/10.1182/blood.v114.22.5088.5088.

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Abstract Abstract 5088 Wilson's disease presenting as fulminant hepatic failure is a rare and poorly recognized disorder, Coombs-negative hemolytic anemia with features of acute intravascular hemolysis can be a major complication, we report a rare case of Wilson's disease causing fulminant hepatic failure associated with hemolytic anemia. A 19 year old female with no significant past medical history who presented to the hospital with a chief complaint of abdominal pain and dark urine. Symptomes started about one week ago, with a mild abdominal pain, over the next two days the patient started n

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Gani, Imran, George Hinnant, Rajan Kapoor, and Natasha Savage. "Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination." Case Reports in Hematology 2019 (October 20, 2019): 1–4. http://dx.doi.org/10.1155/2019/3537418.

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Vaccines aim to prevent disease occurrence, its severity, and resultant complications. Our patient, a 58-year-old male, received seasonal influenza vaccination as part of routine health maintenance. Three days later, he presented with malaise, fever, and yellowish discoloration of eyes. His labs showed hyperbilirubinemia, anemia, elevated lactate dehydrogenase, and low haptoglobin, consistent with hemolytic anemia. Autoimmune hemolytic anemia has been associated with vaccine use and may result from phenomena of molecular mimicry and cross-reactivity with the possible role of vaccine adjuvants

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Castro, Oswaldo L., Mehdi Nouraie, Lori Luchtman-Jones, et al. "Lower Ferritin Concentrations Are Associated with Decreased Hemolysis in Sickle Cell Disease Children without Iron Overload." Blood 114, no. 22 (2009): 2571. http://dx.doi.org/10.1182/blood.v114.22.2571.2571.

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Abstract Abstract 2571 Poster Board II-548 The role of iron in the pathophysiology of sickle cell disease (SCD) is complex and not fully understood. Iron overload is associated with disease severity primarily because multiple transfusions are linked to a severe SCD clinical course. Additionally, hemolysis, also associated with disease severity, increases iron absorption. Iron deficiency decreases red cell MCHC, which lowers Hb S polymerization and thus may improve the clinical manifestations of SCD. Such a hypothesis is supported by our recent observation of a homozygous SCD adult with iron de

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Bianco, Cristiana, Elena Coluccio, Daniele Prati, and Luca Valenti. "Diagnosis and Management of Autoimmune Hemolytic Anemia in Patients with Liver and Bowel Disorders." Journal of Clinical Medicine 10, no. 3 (2021): 423. http://dx.doi.org/10.3390/jcm10030423.

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Anemia is a common feature of liver and bowel diseases. Although the main causes of anemia in these conditions are represented by gastrointestinal bleeding and iron deficiency, autoimmune hemolytic anemia should be considered in the differential diagnosis. Due to the epidemiological association, autoimmune hemolytic anemia should particularly be suspected in patients affected by inflammatory and autoimmune diseases, such as autoimmune or acute viral hepatitis, primary biliary cholangitis, and inflammatory bowel disease. In the presence of biochemical indices of hemolysis, the direct antiglobul

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Spasovski, Dejan, Emilija Sandevska, and Svetlana Krsetvska-Balkanov. "Interrelation between Rheumatic Autoimmune Disease, Autohemolitic Anemia and Cancer Arising as Epiphenomenon on Paraneoplastic Syndrome." International Journal of Clinical Case Reports and Reviews 9, no. 1 (2021): 01–02. http://dx.doi.org/10.31579/2690-4861/169.

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There are hemolytic anemias of different origin. For instance, these states may be induced by means of some exogenic hemolytic factors: by different organic and unorganic hemolytic toxins (phosphorus, phenylhydrazin, saponins, arsenicum, lead and biotoxins – snake venom, mushroom poisons, mycotoxins, etc.), some medical preparations, radiations, some infectious agents and haevy burns. Besides, in some cases, hemolytic anemias are induced by antibodies and immunocompetent cells against own tissues (autoimmune hemolytic anemia).

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Murki, Srinivas, Hemasree Kandraju, and Surekha A. Devi. "Hemolytic Disease of the Newborn- Anti c Antibody Induced Hemolysis." Indian Journal of Pediatrics 79, no. 2 (2011): 265–66. http://dx.doi.org/10.1007/s12098-011-0485-y.

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Fayzullayevna, Usmanova Munira. "ACTUAL PROBLEMS OF DIAGNOSIS OF HEMOLYTIC DISEASE IN NEWBORNS." European International Journal of Multidisciplinary Research and Management Studies 02, no. 04 (2022): 282–89. http://dx.doi.org/10.55640/eijmrms-02-04-54.

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the modern approach of antenatal care in pregnant women with rhesus-immunization means a timely diagnosis of the mutability of the rhesus (Rh) of the fetus through the blood of the mother, the detection of the anaemic syndrome and weight level of the fetus, the use of minimally invasive methods (diagnostic, therapeutic), as well as prevention of the development of immunization in pregnant women. The problem of rhesus-sensibilization in developed countries is rare, and only in immigrants.

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Austin, Publishing Group. "A Case of Autoimmune Metaplastic Atrophic Gastritis with Concurrent Pernicious Anemia and Coombs-Negative Hemolysis." Annals of Hematology & Oncology 10, no. 3 (2023): 1424. https://doi.org/10.26420/annhematoloncol.2023.1424.

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Abstract Pernicious anemia is an autoimmune disease characterized by atrophic gastritis and vitamin B12 deficiency. Concurrent hemolytic anemia has been described, however its prevalence and mechanism are not well understood. Herein, we present the case of a 40-year-old female who presented with abdominal pain, fatigue, and a 50-lb weight loss over four months. She was found to have macrocytic anemia, leukopenia, moderate neutropenia, and severe vitamin B12 deficiency. Further laboratory testing (indirect hyperbilirubinemia, low haptoglobin, increased lactate dehydrogenase, low reticulocyte in

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Jung, Chung Gang, Jang Hoon Lee, and Yu Bin Kim. "Beta Thalassemia Presenting with Neonatal Cholestasis and Extensive Hemosiderosis: A Case Report." Neonatal Medicine 30, no. 4 (2023): 102–7. http://dx.doi.org/10.5385/nm.2023.30.4.102.

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Neonatal cholestasis is caused by various forms of liver injury and has a complex etiological background. Among these, cases of severe cholestasis due to primary hemolytic disease are rare. Herein, we report a case in which thalassemia-induced severe hemolysis caused bile duct injury by hemosiderosis, with cholestasis occurring shortly after birth and lasting for >4 months. In addition, complete recovery of liver pathology was observed both biochemically and histologically. Hence, clinicians should consider hemolytic disease as a rare cause of neonatal cholestasis in the differential diagno

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Padrul, Michael M., Ludmila M. Semyagina, Gulnara K. Sadykova, and Igor Semyagin. "Clinical case of unfavorable pregnancy outcome for the newborn in immunoincompatible pregnancy: difficulties of diagnosis and treatment." Perm Medical Journal 36, no. 3 (2019): 91–97. http://dx.doi.org/10.17816/pmj36391-97.

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During the whole period of gestation, there occur complicated immunobiological mother-fetus relationships, which to a large extent determine further course of pregnancy and outcome for the newborn. Hemolysis of erythrocytes under the influence of antibodies,formed in mothers to fetal erythrocyte antigens, causes hemolytic disease of the fetus/newborn. The problem of hemolytic disease in immunoincompatible pregnancy,first of all in Rh-incompatibility, can’t be considered completely solved in this country,despite the achievements of perinatal medicine. The paper presents a clinical case of unfav

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Gladwin, Mark T., and Gregory J. Kato. "Cardiopulmonary Complications of Sickle Cell Disease: Role of Nitric Oxide and Hemolytic Anemia." Hematology 2005, no. 1 (2005): 51–57. http://dx.doi.org/10.1182/asheducation-2005.1.51.

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Abstract Medical advances in the management of patients with sickle cell disease, thalassemia, and other hemolytic anemias have led to significant increases in life expectancy. Improved public health, neonatal screening, parental and patient education, advances in red cell transfusion medicine, iron chelation therapy, penicillin prophylaxis for children, pneumococcal immunization, and hydroxyurea therapy have all likely contributed to this effect on longevity.1,2 Importantly, as a generation of patients with sickle cell disease and thalassemia ages, new chronic complications of these hemoglobi

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Tamara, Espinosa Martínez, Eugenia Núñez Hernández María, Emir Noguera Echeverría Alexis, et al. "Pregnancy Favism and Severe Hemolytic Anemia in a Patient with Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: A Case Report." International Journal of Medical Science and Clinical Research Studies 5, no. 01 (2025): 74–79. https://doi.org/10.5281/zenodo.14670654.

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<strong>Introduction:</strong> Favism is a genetic disease-causing hemolytic anemia in Mexico, primarily due to glucose-6-phosphate dehydrogenase (G6PD) deficiency. Factors triggering favism include infections, pregnancy, certain drugs, and eating beans. The disease is inherited recessively and is more common in men. Diagnosing and managing favism during pregnancy is crucial, as it can lead to severe hemolytic anemia and neonatal jaundice.   <strong>Case presentation:</strong> A female patient, aged 18, presented with severe anemia and thrombocytopenia during her 20-week pregnan

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35

Maslow, Joel N., David Dawson, Elizabeth A. Carlin, and Steven M. Holland. "Hemolysin as a Virulence Factor for Systemic Infection with Isolates of Mycobacterium aviumComplex." Journal of Clinical Microbiology 37, no. 2 (1999): 445–46. http://dx.doi.org/10.1128/jcm.37.2.445-446.1999.

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Isolates of the Mycobacterium avium complex were examined for hemolysin expression. Only invasive isolates of M. avium were observed to be hemolytic (P < 0.001), with activity the greatest for isolates of serovars 4 and 8. Thus, M. avium hemolysin appears to represent a virulence factor necessary for invasive disease.

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Hill, Anita, and Quentin A. Hill. "Autoimmune hemolytic anemia." Hematology 2018, no. 1 (2018): 382–89. http://dx.doi.org/10.1182/asheducation-2018.1.382.

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Abstract The diagnosis of autoimmune hemolytic anemia (AIHA) can be made with a stepwise approach that aims to identify laboratory and clinical evidence of hemolysis and then determine the immune nature of hemolysis with the direct anti-globulin test. Once alternative causes for these findings have been excluded, AIHA is established, and the clinician must search for secondary causes, as well as identify the type of AIHA. Rituximab is now the preferred second-line treatment for primary warm AIHA and first-line treatment for primary cold agglutinin disease (CAD), either as monotherapy or combin

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Brackstone, M., and Cameron N. Ghent. "Primary Biliary Cirrhosis and Hemolytic Anemia Confusing Serum Bilirubin Levels." Canadian Journal of Gastroenterology 14, no. 5 (2000): 445–47. http://dx.doi.org/10.1155/2000/148063.

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Hemolysis is observed in more than 50% of patients with cirrhosis. However, there has been little documention of the association of primary biliary cirrhosis with autoimmune hemolytic anemia. Two cases, found within a single practice, of primary biliary cirrhosis coexisting with autoimmune hemolysis and a third case coexisting with hereditary spherocytosis are presented. Anemia in such patients is commonly attributed to chronic disease, and hyperbilirubinemia is attributed to primary biliary cirrhosis. These patients were considered for liver transplantation until the diagnosis of a comorbid h

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Brnická, Eva, Jaromír Tupý, and Miriam Tupá. "Hemolytická choroba novorodenca." Zdravotnícke štúdie 14, no. 1 (2022): 30–37. http://dx.doi.org/10.54937/zs.2022.14.1.30-37.

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Neonatal hemolytic disease is a disease characterized by shortened survival and destruction of fetal or neonatal erythrocytes due to hemolysis caused by maternal alloantibodies. It is characterized by a variable spectrum and varying degrees of severity of clinical symptoms, which, despite current advances in diagnosis and management, may result in perinatal mortality.

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Rosse, Wendell F., Peter Hillmen, and Alan D. Schreiber. "Immune-Mediated Hemolytic Anemia." Hematology 2004, no. 1 (2004): 48–62. http://dx.doi.org/10.1182/asheducation-2004.1.48.

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Abstract Hemolytic anemia due to immune function is one of the major causes of acquired hemolytic anemia. In recent years, as more is known about the immune system, these entities have become better understood and their treatment improved. In this section, we will discuss three areas in which this progress has been apparent. In Section I, Dr. Peter Hillmen outlines the recent findings in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH), relating the biochemical defect (the lack of glycosylphosphatidylinositol [GPI]-linked proteins on the cell surface) to the clinical manifestation

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Kaul, Dhananjay K., Xiaoqin Zhang, Trisha Dasgupta, and Mary E. Fabry. "Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 1 (2008): H39—H47. http://dx.doi.org/10.1152/ajpheart.00162.2008.

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In sickle cell disease, nitric oxide (NO) depletion by cell-free plasma hemoglobin and/or oxygen radicals is associated with arginine deficiency, impaired NO bioavailability, and chronic oxidative stress. In transgenic-knockout sickle (BERK) mice that express exclusively human α- and βS-globins, reduced NO bioavailability is associated with induction of non-NO vasodilator enzyme, cyclooxygenase (COX)-2, and impaired NO-mediated vascular reactivity. We hypothesized that enhanced NO bioavailability in sickle mice will abate activity of non-NO vasodilators, improve vascular reactivity, decrease h

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Makević-Đurić, Mirjana, and Milivoje Đurić. "Hemolytic disease of the newborn." Zdravstvena zastita 51, no. 2 (2022): 86–95. http://dx.doi.org/10.5937/zdravzast51-37028.

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Introduction/Aim: Haemolytic disease of the newborn is haemolytic anaemia that occurs as a consequence of mismatched blood of the parents, that is, the mismatch of blood elements between the mother and fetus in the ABO or Rh system. The aim of this study is to report a case of haemolytic disease of the newborn which occurred as a result of ABO incompatibility. Case report: Indirect hyperbilirubinemia was registered in a female newborn in the 18th hour of life. The blood group of the newborn was A Rh (D) positive, the direct Coombs test was positive and anti-A antibodies were detected in baby's

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SPINNATO, JOSEPH A., ANN L. CLARK, KATHLEEN K. RALSTON, EILEEN R. GREENWELL, and L. JANE GOLDSMITH. "Hemolytic Disease of the Fetus." Obstetrics & Gynecology 92, no. 3 (1998): 441–45. http://dx.doi.org/10.1097/00006250-199809000-00024.

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Queenan, John T., Gary S. Eglinton, Thomas P. Tomai, Serdar H. Ural, Jeffrey C. King, and Catherine Y. Spong. "HEMOLYTIC DISEASE OF THE FETUS." Obstetrics & Gynecology 93, no. 1 (1999): 162. http://dx.doi.org/10.1097/00006250-199901000-00044.

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Spinnato, Joseph A., and Ann L. Clark. "HEMOLYTIC DISEASE OF THE FETUS." Obstetrics & Gynecology 93, no. 1 (1999): 162–63. http://dx.doi.org/10.1097/00006250-199901000-00045.

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Spinnato, J. A. "Hemolytic disease of the fetus." American Journal of Obstetrics and Gynecology 166, no. 5 (1992): 1589–90. http://dx.doi.org/10.1016/0002-9378(92)91642-n.

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BOWMAN, JOHN M. "HEMOLYTIC DISEASE OF THE NEWBORN." Vox Sanguinis 70, S3 (1996): 62–67. http://dx.doi.org/10.1111/j.1423-0410.1996.tb01371.x.

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Ketaki, Khandave*1 Mahadev Mundhe2. "Hemolytic Disease of The Newborn." International Journal of Scientific Research and Technology 2, no. 3 (2025): 566–76. https://doi.org/10.5281/zenodo.15097530.

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Hemolytic  disease  of the newborn (HDN), or erythroblastosis fetalis, primarily impacts rhesus-positive fetuses born to rhesus-negative mothers. The condition arises when maternal antibodies, formed after alloimmunization due to rhesus or ABO blood type incompatibility, attack fetal red blood cells. Historically, HDN was associated with a fetal death rate of about 1% in pregnancies. However, advancements in immunoprophylactic treatments have significantly improved management and outcomes when the condition is diagnosed early. Diagnosis involves a comprehensive assessment, including

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Baiko, S. V., E. S. Strelchenia, and S. U. Reut. "Hemolytic uremic syndrome associated with <i>Streptococcus pneumoniae</i>." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 66, no. 6 (2022): 134–41. http://dx.doi.org/10.21508/1027-4065-2021-66-6-134-141.

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Hemolytic uremic syndrome associated with Streptococcus pneumoniae is a rare disease that occurs in 5-10% of all cases of hemolytic uremic syndromes in childhood. Pneumonia and meningitis are among the main diseases that can be complicated by St. pneumoniae-associated hemolytic uremic syndrome. The widespread introduction of polymerase chain reaction into clinical practice has increased the frequency of detection of this pathology. The article presents the epidemiology, clinical picture, features of pathogenesis, diagnosis and treatment of St. pneumoniae-associated hemolytic uremic syndrome. T

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Çelik, Serhat, and Ali Ünal. "Cold autoimmune hemolytic anemia." Journal of Current Hematology & Oncology Research 1, no. 3 (2023): 68–72. http://dx.doi.org/10.51271/jchor-0015.

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Cold agglutinins are antibodies that recognize antigens on erythrocytes at temperatures below normal body temperature. Antibodies are of IgM nature and bind to “I” or “i” antigens on red blood cells, causing agglutination in red blood cells. This situation results in anemia by creating extravascular hemolysis. If there is no underlying disease, it is called primary or idiopathic cold agglutinin disease (CAD), and if there is, it is called secondary cold agglutinin syndrome (CAS). Primary CAD is an extremely rare disease, with an incidence and prevalence of 1 per million and 16 per million, res

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Ravindran, Aishwarya, Janani Sankaran, Min Shi, et al. "Characteristics and Outcome of Direct Antiglobulin Test-Negative Hemolytic Anemia: A Case Series." Blood 128, no. 22 (2016): 2451. http://dx.doi.org/10.1182/blood.v128.22.2451.2451.

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Abstract BACKGROUND: Non-hereditary hemolytic anemia of unknown etiology after an exhaustive work-up is commonly known as direct antiglobulin test (DAT)-negative hemolytic anemia. Due to its rarity, limited data are available regarding this condition. We performed this retrospective study to determine the frequency, associated medical conditions, treatments used, and clinical outcome of patients with DAT- negative hemolytic anemia. METHODS: We included adult (age >18 years) patients with DAT-negative hemolytic anemia seen at Mayo Clinic from 1997-2015 who met all of the following criteria:

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