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Journal articles on the topic 'Hemopoietic stem cell transplantation'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

WESTBROOK, STEVEN D., ELEONORE D. PAUNOVICH, and CESAR O. FREYTES. "Adult hemopoietic stem cell transplantation." Journal of the American Dental Association 134, no. 9 (2003): 1224–31. http://dx.doi.org/10.14219/jada.archive.2003.0357.

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2

Nilsson, Susan K., David N. Haylock, Hayley M. Johnston, Teresa Occhiodoro, Tracey J. Brown, and Paul J. Simmons. "Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro." Blood 101, no. 3 (2003): 856–62. http://dx.doi.org/10.1182/blood-2002-05-1344.

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Abstract The localization of adult hemopoiesis to the marrow involves developmentally regulated interactions between hemopoietic stem cells and the stromal cell–mediated hemopoietic microenvironment. Although primitive hemopoietic cells exhibit a broad repertoire of adhesion molecules, little is known about the molecules influencing the site of cell lodgment within the marrow following transplantation. However, our recent studies indicate that hierarchically dependent patterns of migration of transplanted hemopoietic cells result in the retention of primitive cells within the endosteal and lin

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3

Li, Jau-Yi, Jonathan Adams, Laura M. Calvi, Timothy F. Lane, M. Neale Weitzmann, and Roberto Pacifici. "Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B." Blood 122, no. 14 (2013): 2346–57. http://dx.doi.org/10.1182/blood-2013-03-487801.

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Key Points Ovariectomy expands short-term hemopoietic stem and progenitor cells and improves engraftment and host survival after bone marrow transplantation. T cells are required for ovariectomy to expand hemopoietic stem and progenitor cells.

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4

McCann, Shaun R., Mireille Crampe, Karen Molloy, and Mark Lawler. "Hemopoietic chimerism following stem cell transplantation." Transfusion and Apheresis Science 32, no. 1 (2005): 55–61. http://dx.doi.org/10.1016/j.transci.2004.10.006.

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5

Roifman, Chaim M., Alain Fischer, Luigi D. Notarangelo, M. Teresa de la Morena, and Reinhard A. Seger. "Indications for Hemopoietic Stem Cell Transplantation." Immunology and Allergy Clinics of North America 30, no. 2 (2010): 261–62. http://dx.doi.org/10.1016/j.iac.2010.03.004.

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6

Nagashima, Takahiro, Kazuo Muroi, Chizuru Kawano-Yamamoto, et al. "Pleocytosis after hemopoietic stem cell transplantation." Leukemia & Lymphoma 47, no. 8 (2006): 1613–17. http://dx.doi.org/10.1080/10428190600625836.

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7

Deeg, H. Joachim, and Frederick R. Appelbaum. "Hemopoietic stem cell transplantation for myelodysplastic syndrome." Current Opinion in Oncology 12, no. 2 (2000): 116–20. http://dx.doi.org/10.1097/00001622-200003000-00003.

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8

Bacigalupo, A. "Hemopoietic stem cell transplantation (HSCT) in Europe." European Journal of Cancer 35 (September 1999): S303—S304. http://dx.doi.org/10.1016/s0959-8049(99)81639-6.

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9

Inaguma, Yosuke, Hiroshi Kaito, Atsuro Saito, Daiichiro Hasegawa, Yoshiyuki Kosaka, and Ryojiro Tanaka. "Renal outcome after hemopoietic stem cell transplantation." Japanese journal of pediatric nephrology 33, no. 2 (2020): 115–22. http://dx.doi.org/10.3165/jjpn.oa.2020.0177.

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10

Deeg, H. J., and C. U. Urban. "Bone marrow and hemopoietic stem cell transplantation." European Surgery 26, no. 1 (1994): 34–42. http://dx.doi.org/10.1007/bf02619725.

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11

Korbling, M., B. Dorken, AD Ho, A. Pezzutto, W. Hunstein, and TM Fliedner. "Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma." Blood 67, no. 2 (1986): 529–32. http://dx.doi.org/10.1182/blood.v67.2.529.529.

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Abstract A patient with Burkitt's lymphoma in complete remission received myeloablative consolidation treatment with superfractionated total body irradation (1,320 rad) and cyclophosphamide (200 mg/kg) followed by autologous transplantation of previously harvested and cryopreserved blood-derived hemopoietic stem cells. Seven successive leukaphereses were performed to yield a total of 55.2 X 10(9) mononuclear cells (MNC) comprising 15.1 X 10(6) CFU-GM or 4.34 X 10(6) CFU-GEMM. Following autologous blood stem cell transplantation (ABSCT), reconstitution of all cell lines occurred very rapidly, i

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12

Korbling, M., B. Dorken, AD Ho, A. Pezzutto, W. Hunstein, and TM Fliedner. "Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma." Blood 67, no. 2 (1986): 529–32. http://dx.doi.org/10.1182/blood.v67.2.529.bloodjournal672529.

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A patient with Burkitt's lymphoma in complete remission received myeloablative consolidation treatment with superfractionated total body irradation (1,320 rad) and cyclophosphamide (200 mg/kg) followed by autologous transplantation of previously harvested and cryopreserved blood-derived hemopoietic stem cells. Seven successive leukaphereses were performed to yield a total of 55.2 X 10(9) mononuclear cells (MNC) comprising 15.1 X 10(6) CFU-GM or 4.34 X 10(6) CFU-GEMM. Following autologous blood stem cell transplantation (ABSCT), reconstitution of all cell lines occurred very rapidly, ie, 1,000

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13

Kuzmich, E. A., V. A. Zmachinsky, N. F. Milanovich, and N. A. Novosiolova. "EFFICACY OF THE COMBINED APPLICATION OF HEMOPOIETIC GROWTH FACTORS AFTER STEM HEMOPOIETIC CELL TRANSPLATATION." Health and Ecology Issues, no. 2S (December 28, 2011): 57–59. http://dx.doi.org/10.51523/2708-6011.2011-8-2s-18.

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The restoration of hemopeisis indices after high dose chemotherapy with autologic and allogenic transplantation of stem hemopoeitic cells with the combined use of hemopoietic growth factors - erythropoietin and granulocytic colony-stimulating factor at the early post-trasplantation period has been studied. 268 patients were included into the investigation. The shortening of restoration terms of hemoglobin, leucocytes and neutrophils in the group of patients, undergoing the combined therapy of hemopoietic growth factors after autologic transplantation of stem hemopoeitic cells. The shortening o

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14

Messner, H. A. "Hemopoietic precursors in human bone marrow transplantation." International Journal of Cell Cloning 4, S1 (1986): 11–18. http://dx.doi.org/10.1002/stem.5530040706.

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15

Carnevale-Schianca, F., A. Ricchiardi, A. Capaldi, et al. "Allogeneic Hemopoietic Stem Cell Transplantation in Solid Tumors." Transplantation Proceedings 37, no. 6 (2005): 2664–66. http://dx.doi.org/10.1016/j.transproceed.2005.06.050.

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16

Li, Zihai, Ted Gooley, Frederick R. Appelbaum, and H. Joachim Deeg. "Splenectomy and hemopoietic stem cell transplantation for myelofibrosis." Blood 97, no. 7 (2001): 2180–81. http://dx.doi.org/10.1182/blood.v97.7.2180.

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17

Isoyama, Keiichi, Kei Ohnuma, Koichiro Ikuta, et al. "Unrelated cord blood transplantation for second hemopoietic stem cell transplantation." Pediatrics International 45, no. 3 (2003): 268–74. http://dx.doi.org/10.1046/j.1442-200x.2003.01717.x.

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18

Shi, Jimin, He Huang, Zhen Cai, et al. "Busulfan and Cyclophosphamide for Hemopoietic Stem Cell Transplantation from Related and Unrelated Donors in Patients with Myelodysplastic Syndrome." Blood 112, no. 11 (2008): 4429. http://dx.doi.org/10.1182/blood.v112.11.4429.4429.

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Abstract The myelodysplastic syndromes (MDS) are clonal hemopoietic disorders, characterized by ineffective hemopoiesis resulting in single or multilineage peripheral blood cytopenias, dysplastic morphology in single or multiple lineages, and, in many patients, clonal cytogenetic abnormalities. Hematopoietic stem cell transplantation is currently the only therapeutic modality that is potentially curative. A total of 17 patients (aged 16–40 years; median, 26 years) with MDS were treated with busulfan (BU 3.2 mg/kg/d, −7 d `−4 d,) plus cyclophosphamide (CY, 60 mg/kg, −3 d `−2 d)and hemopoietic s

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19

de Buys, Paige, Dinesh Khanna, and Daniel E. Furst. "Hemopoietic stem cell transplantation in rheumatic diseases—an update." Autoimmunity Reviews 4, no. 7 (2005): 442–49. http://dx.doi.org/10.1016/j.autrev.2005.03.003.

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20

Nilsson, Susan K., Hayley M. Johnston, and Judi A. Coverdale. "Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches." Blood 97, no. 8 (2001): 2293–99. http://dx.doi.org/10.1182/blood.v97.8.2293.

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Abstract The spatial distribution of subpopulations of hemopoietic progenitor cells following syngeneic transplantation was investigated at the single-cell level. The location of infused hemopoietic progenitor cells within the femoral bone marrow of nonablated recipients was determined by 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester labeling of cells and in situ fixation by perfusion. Analysis performed over 15 hours after infusion demonstrated that the spatial distribution of transplanted marrow cells is not a random process. Although the majority of cells enter the bone marrow f

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21

Shaw, Sarah E., David N. Haylock, Hayley M. Johnston, Richard Lock, and Susie K. Nilsson. "The Role of Hyaluronic Acid in Normal and Perturbed Hemopoietic Stem Cell Biology." Blood 108, no. 11 (2006): 708. http://dx.doi.org/10.1182/blood.v108.11.708.708.

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Abstract Considerable evidence supports the proposal that the localisation of hemopoiesis to the bone marrow (BM) involves developmentally regulated adhesive interactions between primitive hemopoietic stem cells (HSC) and the hemopoietic microenvironment of the marrow. Previous studies in our laboratory demonstrate that HSC reside within an endosteal stem cell niche, and identified several key molecules that play critical roles in their attraction to, and retention and regulation within this region. We have previously described Hyaluronic acid (HA) as one of these key molecules and shown that

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22

Abkowitz, Janis L., Daniela Golinelli, David E. Harrison, and Peter Guttorp. "In vivo kinetics of murine hemopoietic stem cells." Blood 96, no. 10 (2000): 3399–405. http://dx.doi.org/10.1182/blood.v96.10.3399.

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Abstract We used stochastic modeling and computer simulation to study the replication, apoptosis, and differentiation of murine hemopoietic stem cells (HSCs) in vivo. This approach allows description of the behavior of an unobserved population (ie, HSCs) on the basis of the behavior of observed progeny cells (ie, granulocytes and lymphocytes). The results of previous limiting-dilution, competitive-repopulation studies in 44 mice were compared with the results of simulated transplantation studies to identify parameters that led to comparable outcomes. Using this approach, we estimated that muri

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23

Abkowitz, Janis L., Daniela Golinelli, David E. Harrison, and Peter Guttorp. "In vivo kinetics of murine hemopoietic stem cells." Blood 96, no. 10 (2000): 3399–405. http://dx.doi.org/10.1182/blood.v96.10.3399.h8003399_3399_3405.

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We used stochastic modeling and computer simulation to study the replication, apoptosis, and differentiation of murine hemopoietic stem cells (HSCs) in vivo. This approach allows description of the behavior of an unobserved population (ie, HSCs) on the basis of the behavior of observed progeny cells (ie, granulocytes and lymphocytes). The results of previous limiting-dilution, competitive-repopulation studies in 44 mice were compared with the results of simulated transplantation studies to identify parameters that led to comparable outcomes. Using this approach, we estimated that murine HSCs r

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24

HARADA, MINE. "Blood transfusion therapy of internal medical field. Hemopoietic stem cell transplantation. Peripheral blood stem cell transplantation." Nihon Naika Gakkai Zasshi 85, no. 6 (1996): 886–91. http://dx.doi.org/10.2169/naika.85.886.

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25

GONDO, HISASHI. "Transplantation of hemopoietic stem cells. IV. Complication of the hemopoietic stem cell transplantation Disease state and countermeasure. 1. Infectious diseases." Nihon Naika Gakkai Zasshi 87, no. 8 (1998): 1495–501. http://dx.doi.org/10.2169/naika.87.1495.

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26

Körbling, M., R. Holle, R. Haas, et al. "Autologous blood stem-cell transplantation in patients with advanced Hodgkin's disease and prior radiation to the pelvic site." Journal of Clinical Oncology 8, no. 6 (1990): 978–85. http://dx.doi.org/10.1200/jco.1990.8.6.978.

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Patients with relapsed Hodgkin's disease who respond to salvage therapy are successfully treated with cyclophosphamide, carmustine (BCNU), and etoposide (VP-16) (CBV) followed by autologus bone marrow transplantation (ABMT). Because of heavy pretreatment including radiation to the pelvic site, marrow harvest was not feasible in those patients. We therefore used blood-derived hemopoietic precursor cells as an alternative stem-cell source to rescue them after superdose chemotherapy. Hemopoietic precursor cells were mobilized into the peripheral blood either by chemotherapeutic induction of trans

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27

Grassinger, Jochen, David N. Haylock, Melonie J. Storan та ін. "Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins". Blood 114, № 1 (2009): 49–59. http://dx.doi.org/10.1182/blood-2009-01-197988.

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AbstractOsteopontin (OPN), a multifunctional acidic glycoprotein, expressed by osteoblasts within the endosteal region of the bone marrow (BM) suppresses the proliferation of hemopoietic stem and progenitor cells and also regulates their lodgment within the BM after transplantation. Herein we demonstrate that OPN cleavage fragments are the most abundant forms of this protein within the BM. Studies aimed to determine how hemopoietic stem cells (HSCs) interact with OPN revealed for the first time that murine and human HSCs express α9β1 integrin. The N-terminal thrombin cleavage fragment of OPN t

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28

O’Keefe, Christine L., Lukasz Gondek, Randall Davis, et al. "Molecular Analysis of Alloreactive CTL Post-Hemopoietic Stem Cell Transplantation." Journal of Immunology 179, no. 3 (2007): 2013–22. http://dx.doi.org/10.4049/jimmunol.179.3.2013.

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29

Lambertenghi Deliliers, Giorgio, Claudio Annaloro, Ermanno Pozzoli, et al. "Cytogenetic and myelodysplastic alterations after autologous hemopoietic stem cell transplantation." Leukemia Research 23, no. 3 (1999): 291–97. http://dx.doi.org/10.1016/s0145-2126(98)00139-8.

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30

Deeg, H. Joachim. "Optimization of Transplant Regimens for Patients with Myelodysplastic Syndrome (MDS)." Hematology 2005, no. 1 (2005): 167–73. http://dx.doi.org/10.1182/asheducation-2005.1.167.

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Abstract Myelodysplastic syndrome (MDS) is a hemopoietic stem cell disorder that is potentially curable by transplantation of normal hemopoietic stem cells. The optimum timing, however, and the best conditioning strategy have remained controversial. Both conventional and reduced-intensity/nonmyeloablative regimens have been used successfully. Among selected patients with less advanced/low-risk MDS (< 5% marrow myeloblasts), 3-year survivals of 65% to 75% are achievable with HLA-matched related and unrelated donors. Among patients with more advanced/ high-risk disease (≥ 5% marrow blasts; hi

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31

Castagnola, E., M. Faraci, C. Moroni, et al. "Rare viral infections in children receiving hemopoietic stem cell transplant." Bone Marrow Transplantation 41, S2 (2008): S100—S103. http://dx.doi.org/10.1038/bmt.2008.65.

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32

Hamadah, Issam, Yousef Binamer, Saad Alajlan, Amr Nassar, and Abu Jafar M. Saleh. "Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation." Hematology/Oncology and Stem Cell Therapy 3, no. 2 (2010): 84–88. http://dx.doi.org/10.1016/s1658-3876(10)50040-2.

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33

d’Amore, Francesco, Esa Jantunen, and Thomas Relander. "Hemopoietic stem cell transplantation in T-cell malignancies: Who, when, and how?" Current Hematologic Malignancy Reports 4, no. 4 (2009): 236–44. http://dx.doi.org/10.1007/s11899-009-0031-4.

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34

Nishimura, M., J. Toki, K. Sugiura, et al. "Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder." Journal of Experimental Medicine 179, no. 3 (1994): 1053–58. http://dx.doi.org/10.1084/jem.179.3.1053.

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The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.

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35

Pellegrini, Marc, Sue Bath, Vanessa S. Marsden, et al. "FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells." Blood 106, no. 5 (2005): 1581–89. http://dx.doi.org/10.1182/blood-2005-01-0284.

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Abstract The role of caspase-8 and its adaptor Fas-associated death domain (FADD) in lymphocyte apoptosis is well defined, but their functions in other hemopoietic lineages are not clear. We were unable to generate transgenic mice expressing dominant inhibitors of FADD or caspase-8 in hemopoietic cells, possibly because their expression may have precluded production of vital hemopoietic cells. When using a retroviral gene delivery system, fetal liver stem cells expressing a dominant-negative mutant of FADD (FADD-DN) were unable to generate myeloid or lymphoid cells upon transplantation into le

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36

Aguilar, Laura K., Cliona M. Rooney, and Helen E. Heslop. "Lymphoproliferative disorders involving Epstein-Barr virus after hemopoietic stem cell transplantation." Current Opinion in Oncology 11, no. 2 (1999): 96. http://dx.doi.org/10.1097/00001622-199903000-00004.

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37

Fassas, Athanasios, and Gian Luigi Mancardi. "Autologous hemopoietic stem cell transplantation for multiple sclerosis: Is it worthwile?" Autoimmunity 41, no. 8 (2008): 601–10. http://dx.doi.org/10.1080/08916930802197347.

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38

Deliliers, Giorgio Lambertenghi, Elena Tagliaferri, Claudio Annaloro, et al. "G-CSF After Autologous Hemopoietic Stem Cell Transplantation in Malignant Lymphoma." Prostaglandins & Other Lipid Mediators 56, no. 1 (1998): 33–42. http://dx.doi.org/10.1016/s0090-6980(98)00038-0.

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39

Feldman, Leonardo, Alejandro M. Requejo, Gregorio Jaimovich, et al. "Autologous Hemopoietic Stem-Cell Transplantation in Patients with Preexisting Cardiac Abnormalities." Blood 108, no. 11 (2006): 2982. http://dx.doi.org/10.1182/blood.v108.11.2982.2982.

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Abstract INTRODUCTION: High dose chemotherapy and autologous hemopoietic stem cells transplantation (AHSCT) represents an useful treatment for patients undergoing hematological diseases. Relapsed lymphomas, acute leukemias and multiple myeloma achieve a better outcome with a low incidence of complications and mortality related to the procedure. Assessment of pre-transplant organ function (including cardiopulmonary, kidney and liver) is a routine part of eligibility criteria for AHSCT protocols. Left ventricle (LV) function has been considered one of the most important risk factor in predicting

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40

Kist-van Holthe, J. E., D. Bresters, Y. M. Ahmed-Ousenkova, et al. "Long-term renal function after hemopoietic stem cell transplantation in children." Bone Marrow Transplantation 36, no. 7 (2005): 605–10. http://dx.doi.org/10.1038/sj.bmt.1705110.

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41

Au, W. Y. "Relevance of drug allergy history after allogeneic hemopoietic stem cell transplantation." Bone Marrow Transplantation 40, no. 2 (2007): 179–80. http://dx.doi.org/10.1038/sj.bmt.1705705.

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42

MULLIGHAN, CHARLES G., and PETER G. BARDY. "Mannose-binding Lectin and Infection Following Allogeneic Hemopoietic Stem Cell Transplantation." Leukemia & Lymphoma 45, no. 2 (2004): 247–56. http://dx.doi.org/10.1080/1042819031000146983.

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43

Wulffraat, Nico M., Lieke AM Sanders, and Wietse Kuis. "Autologous hemopoietic stem-cell transplantation for children with refractory autoimmune disease." Current Rheumatology Reports 2, no. 4 (2000): 316–23. http://dx.doi.org/10.1007/s11926-000-0069-8.

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44

Wicks, Ian, Helen Cooley, and Jeff Szer. "Autologous hemopoietic stem cell transplantation. A possible cure for rheumatoid arthritis?" Arthritis & Rheumatism 40, no. 6 (1997): 1005–11. http://dx.doi.org/10.1002/art.1780400603.

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45

Riezzo, Irene, Natascha Pascale, Raffaele La Russa, Arcangelo Liso, Monica Salerno, and Emanuela Turillazzi. "Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations." Stem Cells International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5250790.

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Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. HSCT imposes operative cautions so that the

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46

Nivison-Smith, I., K. F. Bradstock, A. J. Dodds, D. D. F. Ma, and J. Szer. "Measurement of mortality in long-term hemopoietic stem cell transplant survivors." Biology of Blood and Marrow Transplantation 12, no. 2 (2006): 108. http://dx.doi.org/10.1016/j.bbmt.2005.11.334.

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47

FRANCESCUTTI, L. H., P. GAMBEL, and T. G. WEGMANN. "CHARACTERIZATION OF HEMOPOIETIC STEM CELL CHIMERISM IN ANTIBODY-FACILITATED BONE MARROW CHIMERAS." Transplantation 40, no. 1 (1985): 7–11. http://dx.doi.org/10.1097/00007890-198507000-00002.

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48

Ellis, Sarah L., Jochen Grassinger, Allan Jones, et al. "The relationship between bone, hemopoietic stem cells, and vasculature." Blood 118, no. 6 (2011): 1516–24. http://dx.doi.org/10.1182/blood-2010-08-303800.

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Abstract A large body of evidence suggests hemopoietic stem cells (HSCs) exist in an endosteal niche close to bone, whereas others suggest that the HSC niche is intimately associated with vasculature. In this study, we show that transplanted hemopoietic stem and progenitor cells (HSPCs) home preferentially to the trabecular-rich metaphysis of the femurs in nonablated mice at all time points from 15 minutes to 15 hours after transplantation. Within this region, they exist in an endosteal niche in close association with blood vessels. The preferential homing of HSPCs to the metaphysis occurs rap

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49

Derudas, Daniele, Donatella Baronciani, Cristina Depau, et al. "Safety, Feasibility and Cost Of Hematopoietic Stem Cell Transplantation Management By Peripheral Inserted Central Catheter (PICC): A Phase II Prospective Study." Blood 122, no. 21 (2013): 2971. http://dx.doi.org/10.1182/blood.v122.21.2971.2971.

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Abstract Background The management of high dose chemotherapy followed by autologous or allogeneic hemopoietic stem cell transplantation requires an intravenous line for administrations of high-dose chemotherapy, blood and platelet transfusions, antibiotics and parenteral nutrition. In this context a safe central venous access is a basic tool for patients management. The aim of our phase II prospective study is to evaluate feasibility, safety and cost of the use of peripherally inserted central catheters (PICC) for the management of hemopoietic stem cell transplantation. Methods Inclusion crite

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50

Li, Jau-Yi, Jonathan Adams, Laura M. Calvi, et al. "PTH expands short-term murine hemopoietic stem cells through T cells." Blood 120, no. 22 (2012): 4352–62. http://dx.doi.org/10.1182/blood-2012-06-438531.

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Abstract Intermittent parathyroid hormone (iPTH) treatment expands hemopoietic stem and progenitor cells (HSPCs), but the involved mechanisms and the affected HSPC populations are mostly unknown. Here we show that T cells are required for iPTH to expand short-term HSPCs (ST-HSPCs) and improve blood cell engraftment and host survival after BM transplantation. Silencing of PTH/PTH-related protein receptor (PPR) in T cells abrogates the effects of iPTH, thus demonstrating a requirement for direct PPR signaling in T cells. Mechanistically, iPTH expands ST-HSPCs by activating Wnt signaling in HSPCs

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