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Dissertations / Theses on the topic 'Hemopoietic stem cells and induced pluripotent stem cells'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Sartori, Chiara. "Generation of ovine induced pluripotent stem cells." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6491.

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Embryonic stem cells (ESCs) are pluripotent cells derived from the early embryo and are able to differentiate into cells belonging to the three germ layers. They are a valuable tool in research and for clinical use, but their applications are limited by ethical and technical issues. In 2006 a breakthrough report described the generation of induced pluripotent stem cells (iPSCs). IPSCs are ESC-like cells generated from somatic cells by forcing the ectopic expression of specific transcription factors. This circumvents the ethical issues about the use of embryos in research and provides multiple

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2

Veiga, Bruno Rafael Assis da. "Induced pluripotent stem cells: tradução e terminologia." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10636.

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Mestrado em Tradução Especializada<br>Nos dias de hoje existe uma controvérsia enorme em torno do uso de células estaminais provenientes do cordão umbilical e das células estaminais de fetos. Esta é uma controvérsia com a qual os cientistas têm lidado todos os dias. Agora existe um tipo células em tudo semelhante às células estaminais, no entanto, estas não provêm de células estaminais de fetos ou do cordão umbilical, mas sim de células maduras – células da pele. De forma a conciliar a necessidade de realizar um projeto de tradução especializada com a vontade de divulgar um tema tão important

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3

Adams, William James. "Human Vascular Endothelium from Induced Pluripotent Stem Cells." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10816.

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The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-der

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4

Sendfeld, Franziska. "Modelling Brugada Syndrome using induced pluripotent stem cells." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19557.

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Objective: Brugada Syndrome is an autosomal dominant congenital heart disease that is responsible for 20% of sudden deaths of patients with structurally normal hearts. The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an abnormal electrocardiogram with ST segment elevation and a predisposition to ventricular fibrillation. To date, the implantation of a cardioverter defibrillator is the only proven effective treatment of the disease. The ability to reprogram dermal fibroblasts to induced pluripotent stem (iPS) cells and to

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5

Morishima, Tatsuya. "Neutrophil differentiation from human-induced pluripotent stem cells." Kyoto University, 2011. http://hdl.handle.net/2433/151911.

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6

Sharma, Ruchi. "Generation of equine induced pluripotent stem cells from keratinocytes." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17956.

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Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to an embryonic state. Therefore iPSCs represent an extremely valuable tool for modelling disease and organ toxicity, with enormous potential in veterinary medicine. Several equine diseases are currently untreatable and can result in euthanasia on medical grounds. In contrast to humans, in vitro models for cellular research in equine do not exist. Therefore it has been necessary to explore the use of stem cells in constructing cell based equine models. Pluripotent stem cell populations are of great interest in

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7

Shum, Carole Yick Lam. "Modelling motor neuron disease using induced pluripotent stem cells." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/modelling-motor-neuron-disease-using-induced-pluripotent-stem-cells(1686136a-d045-4edc-9439-1028b0ea47db).html.

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Amyotrophic Lateral Sclerosis (ALS) is the most common adult motor neuron disease. The majority of ALS cases are sporadic (SALS), but 10% of patients have a familial form of ALS (FALS). Mutations in Fused in Sarcoma (FUS) occur in approximately 4% of FALS and less than 1% of SALS. A hallmark feature of ALS is the degeneration of upper and lower motor neurons in the brain and spinal cord; however, the mechanism underlying this loss is not known. Studies of degenerative mechanisms have been impeded by the inaccessibility of human neural tissue. A possible solution is to use induced pluripotent s

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8

McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and ag

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9

BACI, DENISA. "Human induced pluripotent stem cells for skeletal muscle diseases." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/201887.

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Regenerative medicine along with tissue engineering represent two closely related fields leading promising advances for the treatment of numerous musculoskeletal diseases and injuries. Nevertheless, new efforts are urgently needed to design a successful therapeutic approach for muscular disorders, aiming at identifying a functional stem cell population and biomaterial scaffolds in which cells and growth factors could be embedded. In this context, recent studies have suggested that reprogramming of somatic cells by defined transcription factors into induced pluripotent stem cells (iPS), as sour

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10

Taura, Daisuke. "Induction and isolation of vascular cells from human induced pluripotent stem cells." Kyoto University, 2010. http://hdl.handle.net/2433/97941.

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11

Hirami, Yasuhiko. "Generation of retinal cells from mouse and human induced pluripotent stem cells." Kyoto University, 2010. http://hdl.handle.net/2433/97948.

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12

Rouhani, Foad Jafari. "Natural and modified variations in human induced pluripotent stem cells." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708541.

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13

Qin, Jie [Verfasser]. "Enhancing differentiation of human induced pluripotent stem cells / Jie Qin." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1066813477/34.

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14

Di, Stefano Bruno 1984. "C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells". Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/283484.

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One of the major goals of current stem cell research is understanding the mechanism of somatic cell reprogramming by Oct4, Sox2, Klf4 and Myc (OSKM) into induced pluripotent stem cells (iPSCs). However, the finding that only a small proportion of the cells become reprogrammed, typically requiring >12 days, has hampered progress towards this goal. C/EBPα is a transcription factor specifically expressed in myelomonocytic cells within the hematopoietic system whose forced expression in B cells efficiently induces transdifferentiation into macrophages. We have now found that an 18-hour pul

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15

Wang, Xiaoying [Verfasser]. "Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells / Xiaoying Wang." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065413998/34.

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16

Yang, Chian. "Derivation of purified smooth muscle cells from mouse induced pluripotent stem (iPS) cells." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12250.

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Thesis (M.S.)--Boston University<br>Cardiac and vascular disease syndromes and abnormalities have long been the leading causes of death in the United States, but the cause of congenital defects remain unclear due to the lack of appropriate model systems for scientific investigation. Moreover, the predominance of cardiovascular disease has stimulated scientists to focus on developing tissue-engineered blood vessels (TEBV) for vascular reconstruction and replacement. Major challenges remain in generating large amounts of epithelial cells (EC) and vascular smooth muscle cells (VSMC) for vascular

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17

Clayton, Zoe Ellen. "The pro-angiogenic properties of induced pluripotent stem cell derived endothelial cells and induced endothelial cells." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17300.

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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, (1, 2). Current interventions are ineffective in up to 30% of patients due to the presence of diffuse or extensive atherosclerosis, therefore the development of alternative or supplementary therapies for CVD is a high priority for medical research. Therapeutic angiogenesis, enhancing the growth of new blood vessel networks from the existing vasculature, is a promising strategy for restoring blood flow to ischaemic tissue. Stem cells have shown potential as pro-angiogenic therapies for patients with coronary

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18

Francis, Natalie. "Induced pluripotent stem cells as an alternative to embryonic stem cells for the treatment of type 1 diabetes." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25013.

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Type 1 diabetes mellitus (T1DM) results from auto-immune destruction of the insulin-secreting β-cells of the pancreas. The most common treatment is injection of exogenous insulin, but this allows only partial control over blood glucose levels, so other therapies are needed. Pancreatic islet transplantation has shown proof of principle for cell replacement therapy to treat T1DM. There are several sources of cells which could be used, but much of the focus has been on pluripotent stem cells, which are able to self-renew indefinitely in culture and give rise to any cell in the body. Insulin-expre

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19

Awaya, Tomonari. "Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells." Kyoto University, 2013. http://hdl.handle.net/2433/180602.

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20

Yoshimatsu, Masayoshi. "In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265189.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23417号<br>医博第4762号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授松田秀一特定拠点, 教授妻木範行, 教授安達泰治<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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21

Di, Guglielmo Claudia. "Biotechnological approaches to cardiac differentiation of human induced pluripotent stem cells." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/385921.

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The heart can be considered the most important organ of our body, as it supplies nutrients to all the cells. When affected from injuries or diseases, the heart function is hampered, as the damaged area is substituted by a fibrotic scar instead of functional tissue. Understanding the mechanisms leading to heart failure and finding a cure for cardiac diseases represents a major challenge of modern medicine, since they are the leading cause of death and disability in Western world. Being the heart a vital organ it is difficult to have access to its cells, especially in humans. In order to model i

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22

Kelly, Maebh. "Developing lentiviral tools to generate and characterise induced pluripotent stem cells." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601177.

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Induced pluripotent stem cells can be generated by the forced expression of certain pluripotency factors, but little is known about the molecular changes underpinning this process. Micro-RNAs regulate many cell processes and have recently been show to have a role in the generation of iPS cells. In this thesis, we firstly set up a protocol to generate iPS cells in our lab and then investigate a role for stem cell specific miR-371 in the generation of pluripotent stem cells. Overexpression of miR-371 in addition to OCT4, SOX2, NANOG and LIN28 promotes pluripotency. MiR-371 directly targets RBL2

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23

Rohani, Leili, Claire Fabian, Heidrun Holland, et al. "Generation of human induced pluripotent stem cells using non-synthetic mRNA." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205889.

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Here we describe some of the crucial steps to generate induced pluripotent stemcells (iPSCs) usingmRNA transfection. Our approach uses a V. virus-derived capping enzyme instead of a cap-analog, ensuring 100% proper cap orientation for in vitro transcribedmRNA. V. virus\' 2′-O-Methyltransferase enzymecreates a cap1 structure found in higher eukaryotes and has higher translation efficiency compared to other methods. Use of the polymeric transfection reagent polyethylenimine proved superior to other transfection methods. The mRNA created via this method did not trigger an intracellular immune res

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24

Wills, Lauren Raquel. "Investigating Induced Pluripotent Stem Cells for Tissue Engineering and Hepatotoxicity Applications." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/101006.

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Induced pluripotent stem cells (iPSCs) can be differentiated into multiple cell types in the body while maintaining proliferative capabilities. The generation of human iPSC-derived hepatocytes (iPSC-Heps) has resulted in a new source for hepatic cells. The current available options for human hepatocytes are primary human hepatocytes (PHHs) and cell lines. PHHs isolated from healthy human donors are difficult to obtain, while cell lines exhibit reduced hepatotoxic sensitivity. iPSC-Heps are being investigated as an alternative option as they are derived from a continuous, stable source and

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25

Martins, Soraia [Verfasser]. "Modelling neurological diseases using patientderived induced pluripotent stem cells / Soraia Martins." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1235755886/34.

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26

Barbuti, Peter Antony. "Generating patient-derived induced pluripotent stem cells to model Parkinson's disease." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.691252.

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Parkinson's disease (PD) is a chronic progressive neurodegenerative disease of which there is no cure. PD occurs due to the selective degeneration of A9 midbrain dopaminergic neurons (mDANs) of the substantia nigra pars compacta (SNc) of the midbrain. Stem cells have the ability to generate any cell in the body, including the A9 mDANs of the SNc that are selectively degenerated in PD. However, in order to improve treatment for PD, these mDANs of the SNc need to be successfully recapitulated in-vitro, and is thus the central dogma of this research.

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27

Al-Obaidi, Aida Hameed Hassan. "Preclinical studies for cartilage tissue engineering using induced pluripotent stem cells." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738237.

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28

Yamashiro, Chika. "Generation of human oogonia from induced pluripotent stem cells in vitro." Kyoto University, 2019. http://hdl.handle.net/2433/242826.

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29

SALA, LUCA. "Long QT Syndrome modelled with human induced pluripotent stem cells (hiPSc)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/55330.

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Cardiac arrhythmias arise when the myocardium is electrically unstable. They represent a life-threatening phenomena with more than 300,000 people dying every year for arrhythmic sudden cardiac death (SCD) only in the United States. One of the most important and well described arrhythmic condition is the Long QT Syndrome (LQTS). LQTS is an heterogeneous disorder of myocardial repolarization characterized by a prolongation of QT interval on the electrocardiogram and clinically manifested with syncopal episodes and SCD. Mutations in 13 genes regulating cardiac action potential (AP) have been foun

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30

Chen, Xike. "Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage." Kyoto University, 2019. http://hdl.handle.net/2433/242390.

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31

Li, Xiang. "Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/58260.

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation that is not fully reversible and is usually caused by cigarette smoke (CS). The disease is predicted to be the fourth leading cause of death by 2030, but none of the currently available treatments can alleviate the progressive decline in lung function. Mesenchymal stem cells (MSCs) are fibroblast-like multipotent stem cells that can be isolated from various tissues such as bone marrow (BM-MSCs). Despite numerous reports of their efficacy in COPD-related pre-clinical mod

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32

MAZZARA, PIETRO GIUSEPPE. "TWO FACTOR BASED REPROGRAMMING OF FIBROBLASTS AND INDUCED PLURIPOTENT STEM CELLS INTO MYELINOGENIC SCHWANN CELLS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199039.

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Le cellule di Schwann (SC) sono cellule derivate dalla cresta neurale (NC) in grado di produrre la guaina mielinica avvolgendo gli assoni neuronali nel sistema nervoso periferico (PNS). I trapianti di SC potrebbero diventare un'opportunità terapeutica interessante per il trattamento delle lesioni del midollo spinale, dei nervi periferici e delle malattie demielinizzanti del PNS. Tuttavia, questi approcci terapeutici sono fortemente limitati dall'attuale mancanza di una fonte rinnovabile di SC. Le strategie di riprogrammazione cellulare si sono rivelate efficaci nel fornire una varietà di cellu

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33

Zhang, Jiao, and 张姣. "Regulation of cell proliferation and modulation of differentiation in human induced pluripotent stem cell-derived mesenchumal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617503.

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Functional mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (iPSCs) may represent an unlimited cell source with superior therapeutic benefits for tissue regeneration to somatic tissue, such as bone marrow (BM)-derived MSC. In the first part of this project, I investigated whether the differential expression of ion channels in iPSC-MSCs was responsible for their higher proliferation capacity than that of BM-MSCs. The expression of ion channels for K+, Na+, Ca2+ and Cl- currents was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The function

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34

DiVincenzo, Lola S. "DIRECTION OF INDUCED PLURIPOTENT STEM CELL DIFFERENTIATION BY ENDOTHELIAL CELL SECRETOME." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1438031276.

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35

Tan, Yan. "Raman spectroscopic study of induced pluripotent stem cells : characterization, identification, and discrimination." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40716.

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Raman microspectroscopy is a non-destructive, label-free technique that offers information-rich molecular analysis of living cells. This work is the first reported Raman spectroscopic study of human induced pluripotent cells (hiPSCs), a very promising new source of non-embryonic pluripotent stem cells for drug screening, toxicity assessment, regenerative therapies, and clinical research. The Raman signatures of hiPSCs and human embryonic stem cells (hESCs) were found to be highly similar, and both distinguishable from differentiated hESCs in terms of relative Raman peak intensities and varianc

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36

Boza, Maria Gabriela. "Modelling SMA using induced pluripotent stem cells from a discordant affected family." Thesis, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589610.

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Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease in which low levels of survival of motor neuron (SMN) protein lead to the degeneration of alpha motor neurons (MNs) in the spinal cord. The pathological mechanism of SMA is highly controversial and until recently it was not possible to obtain human MNs to study the disease. The development of induced pluripotent stem cell (iPSC) technology has made it possible to bypass this obstacle and iPSC-based models of SMA type I have already been validated by two separate groups. Encouraged by these pioneering findings I have

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37

Chung, Julia. "Manipulating Somatic Cells to Remove Barriers in Induced Pluripotent Stem Cell Reprogramming." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10772.

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Development leads unidirectionally towards a more restricted cell fate that is usually stable. However, it has been proven that developmental systems are reversible by the success of animal cloning of a differentiated somatic genome through somatic cell nuclear transfer (SCNT). Recently, reprogramming of somatic cells to a pluripotent embryonic stem cell (ESC)-like state by introducing defined transcripton factor has been achieved, resulting in the generation of induced pluripotent stem cells (iPSCs), which resemble ESCs. iPSC reprogramming is of great medical interest, as it has the potential

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38

Owaidah, Amani Yousef. "Factors that control the chondrogenic differentiation of human induced pluripotent stem cells." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.652038.

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Articular cartilage is a white connective tissue covering the ends of long bones to facilitate movement and articulation. Due to the avascular nature of the tissue, it has a limited capacity to repair once damaged. Human induced pluripotent stem cells are suggested as an ethical and ultimate source for cell based-therapies. Tissue engineering using these cells might present as a promising treatment for cartilage defects. Previous tissue engineering attempts using multipotent stem cells such as adult msenchymal stem cells or pluripotent stem cells such as embryonic stem cells were qualitative,

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Buchrieser, Julian. "Understanding human mononuclear phagocyte ontogeny using human induced pluripotent stem cells (iPSCs)." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:aaf18203-5f30-4d6a-8f51-3096b29af252.

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Tissue-resident macrophages (MΦ) such as microglia, Kupffer and Langerhans cells derive from Myb-independent yolk sac (YS) progenitors generated before the emergence of hematopoietic stem cells (HSCs). Myb-independent YS-derived resident MΦ self-renew locally, independently of circulating adult monocytes and HSCs. In contrast, adult blood monocytes as well as infiltrating, gut and dermal MΦ derive from Myb-dependent HSCs and are less proliferative. These findings are derived from the mouse, using gene knock-outs and lineage tracing, but their applicability to human development has

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Ababneh, Nidaa. "Modelling of amyotrophic lateral sclerosis (ALS) using induced pluripotent stem cells (iPSC)." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b0e48523-2acc-4c1e-83a5-79696cbaf042.

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The hexanucleotide repeat expansion (HRE) mutation within C9orf72 gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Several hypotheses have been proposed for how the mutation contributes to pathogenicity, including the loss of C9orf72 gene function, RNA-mediate toxicity and the formation of toxic dipeptides by repeat-associated non-ATG (RAN) translation. Patient-specific iPSCs provide a promising tool for the study of the cellular and molecular mechanisms of human diseases in relevant cell types and discovering potential therapies. The CRIS

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Nevin, Zachary Scott. "MODELING GENETIC DISEASES OF MYELIN USING PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case149943464888633.

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42

Kajiwara, Masatoshi. "Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells." Kyoto University, 2013. http://hdl.handle.net/2433/170075.

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43

Shimamoto, Ren. "Generation and Characterization of Induced Pluripotent Stem Cells from Aid-deficient Mice." Kyoto University, 2014. http://hdl.handle.net/2433/189672.

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Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, et al. (2014) Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLoS ONE 9(4): e94735. doi:10.1371/journal.pone.0094735<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第18515号<br>医科博第56号<br>新制||医科||4(附属図書館)<br>31401<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授斎藤通紀, 教授平家俊男, 教授山田泰広<br>学位規則第4条第1項該当

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Tan, Yuan. "Using induced pluripotent stem cells to establish disease models with neurodegenerative disorders." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952490.

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45

RISO, P. LO. "INDUCED PLURIPOTENT STEM CELLS: AN INNOVATIVE TOOL TO DISSECT OVARIAN CANCER PATHOGENESIS." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366384.

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Ovarian cancer (OC) has one of the highest death-to-incidence ratios among all tumor types, which points to the need for novel therapeutic and prognostic strategies. Indeed, the absence of relevant tumor cell lines that can recapitulate disease histopathology highlights an acute need for new model systems to study this pathology. In particular, it is still unclear whether the most common and aggressive form of this disease, high grade serous ovarian cancer (HGSOC), could arise from in the ovarian surface epithelium (OSE), as initially thought, or might be arising from the fimbrial epithelium.

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MONTAGNA, ANNA. "Induced pluripotent stem cells (IPSCS) for modelling mucopolysaccharidosis type I (Hurler syndrome)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/113869.

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Mucopolysaccharidosis type I (MPS-IH or Hurler syndrome) is a rare lysosomal storage disease caused by mutations in the IDUA gene, resulting in the deficiency of alpha-L-iduronidase (IDUA) enzyme activity with a consequent intracellular accumulation of glycosaminoglycans (GAGs). Among a broad spectrum of clinical manifestations, MPS-IH is characterized by a range of skeletal abnormalities known as dysostosis multiplex. To date, the skeletal pathogenesis of the MPSs has been assumed to be directly related to the progressive storage of GAGs. It is now clear that more complex cellular and molecul

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Chokesuwattanaskul, S. "The use of induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) to study the genetic basis of human diseases." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3006683/.

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Objectives: The aim of this thesis was to evaluate the potential of new technologies, including two stem cell technologies, mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), to understand the molecular basis of human diseases. These technologies were evaluated for their ability to restore diabetes-induced defects in wound tissue repair (MSCs) and to generate mature neutrophils after in vitro differentiation of iPSCs. The latter used iPSCs from a patient with abnormal function due to impaired WASp (Wiskott Aldrich syndrome protein) signalling. Other techniques evaluated

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Sachamitr, Supatra. "Exploiting the use of induced pluripotent stem cell derived immune cells for immunotherapy." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:89315b6b-a8cd-4a6f-8c43-3506d8dd1725.

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Immunotherapy traditionally made use of biological agents such as cytokines and monoclonal antibodies. Such first generation therapies lack antigen specificity and fail to induce immunological memory, suggesting that cell therapies may provide the next generation of treatments that are more discerning in their mode of action. Nevertheless, difficulties in obtaining sufficient immunologically-relevant cell types from patients has limited their success. Given that induced pluripotent stem cells (iPSC) may be generated from patients, we have investigated the feasibility of deriving two cell types

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Manzar, Gohar Shahwar. "Generation and function of glucose-responsive insulin producing cells derived from human induced pluripotent stem cells." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5808.

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Type I diabetes (T1D) is caused by autoimmune destruction of pancreatic β-cells. Immediate consequences of T1D are severe weight loss, ketoacidosis and death unless insulin is administered. The long-term consequences of T1D are dysregulation of metabolism leading to cardiovascular complications, neuropathy and kidney insufficiency. It is estimated that 3 million Americans have T1D, and its prevalence among young individuals is progressively rising. Islet transplantation is the most effective way to treat T1D. Unfortunately, there is a chronic shortage of cadaveric organ donors to treat all of

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Kawaguchi, Takamasa. "Studies on induction of pluripotency in bovine somatic cells and generation of induced pluripotent stem cells." Kyoto University, 2016. http://hdl.handle.net/2433/215965.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19899号<br>農博第2182号<br>新制||農||1043(附属図書館)<br>学位論文||H28||N5003(農学部図書室)<br>32976<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授今井裕, 教授久米新一, 教授廣岡博之<br>学位規則第4条第1項該当

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