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Journal articles on the topic 'Hemorrhagic Stroke Ischemic Stroke Plasma Fibrinogen Level'

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Published: 5 June 2025

Last updated: 15 July 2025

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1

Listra, Isabela Barus*1 Puji Pinta O. Sinurat2 &. Chairil Amin Batubara2. "THE DIFFERENCES OF ANTITHROMBIN III, FIBRINOGEN, AND TROPONIN I LEVELS BETWEEN ACUTE ISCHEMIC STROKE AND ACUTE HEMORRHAGIC STROKE." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 6, no. 4 (2019): 17–21. https://doi.org/10.5281/zenodo.2656417.

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<strong>Introduction:</strong> Plasma antithrombin III associated with fibrinogen might help the risk assessment of acute ischemic stroke, but studies that discuss those levels in hemorrhagic stroke are still limited. Troponin I is a cardiac enzyme that has high sensitivity and specificity in the detection of heart injury after stroke. The purpose of this study is to determine the differences of antithrombin III, fibrinogen, and troponin I levels between acute ischemic stroke and acute hemorrhagic stroke.   <strong>Method:</strong> This study used a descriptive analytic study with a

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Dr., Tahira Jabeen Dr. Shaheena Nawab Dr. Muhammad Naveed Abbas. "AN ASSESSMENT OF SERUM FIBRINOGEN LEVELS IN PATIENT OF ACUTE STROKE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 15010–14. https://doi.org/10.5281/zenodo.3373788.

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<strong><em>Objective:  </em></strong><em>To assess the serum fibrinogen levels in patient of stroke presenting at BVH Bahawalpur.</em> <strong><em>Material and methods: </em></strong><em>This cross-sectional study was conducted at Department of Pathology, Quaid-e-Azam Medical College/BVH, Bahawalpur from September 2018 to March 2019 over the period of 6 months.  Total 50 patients with first-ever stroke admitted within 24 h after stroke onset either male or female were selected for this study.  Serum fibrinogen levels were assessed in selected patients.  </em> <strong><em>R

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CAO, Yong-jun, Xia ZHANG, Wan-hua WANG, et al. "Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial." Chinese Medical Journal 126, no. 21 (2013): 4060–65. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20131332.

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Background Elevated fibrinogen (Fg) level is a known risk factor for ischemic stroke. There are few clinical trials on oral fibrinogen-depleting therapies for secondary ischemic stroke prevention. We aimed to assess the effects of one-year therapy with oral lumbrokinase enteric-coated capsules on secondary ischemic stroke prevention. Methods This is a multicenter, randomized, parallel group and controlled study that began treatment in hospitalized patients with ischemic stroke and continued for 12 months. Patients were randomized to either the control group that received the standard stroke tr

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Ziakas, G. "Lipids and fibrinogen plasma levels in ischemic and hemorrhagic stroke. our experience in 2538 patients." American Journal of Hypertension 13, no. 6 (2000): S234—S235. http://dx.doi.org/10.1016/s0895-7061(00)00918-3.

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Chinybayeva, A. A., L. K. Karazhanova, J. A. Mansurova, and A. S. Zhunuspekova. "Features of the Course of Various types of Stroke in Patients Exposed to Low-dose Radiation." Open Access Macedonian Journal of Medical Sciences 11, B (2023): 104–8. http://dx.doi.org/10.3889/oamjms.2023.11106.

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BACKGROUND: There is limited number of studies about peculiarities of cardiovascular diseases in population of different region by the zone of radiation exposure risk. AIM: The aim of the study was to study the effect of radiation factor on the pathogenesis of stroke. MATERIALS AND METHODS: To study the in influence of radiation factor on pathogenesis of stroke, 358 stroke patients were distributed based on the place of their residence into corresponding zones of radiation risk: 53 patients lived in zone of extremely high radiation level (488–100 cSV, zone I): 75 - from the zone of maximal rad

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Mandal, SK, M. Majumder, MS Hossain, and M. Sarker. "Serum Ferritin and Plasma Fibrinogen Level in Acute Ischemic Stroke." Bangladesh Journal of Medical Biochemistry 10, no. 1 (2018): 16–20. http://dx.doi.org/10.3329/bjmb.v10i1.36694.

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Acute ischemic stroke is the primary pathology of brain vascular system that temporarily or permanently affects brain functions as a result of ischemia. In ischemic stroke events, many biochemical and immunological reactions occur secondarily in response to the reduced cerebral blood flow. Brain tissue damage after acute ischemic stroke is mediated partly by inflammation induced by ischemia-reperfusion injury. It is thought that acute ischemic stroke due to cerebral ischemia triggers acute phase reaction and the blood concentration of ferritin and fibrinogen could rise during brain infarction.

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Khandait, Vinod, and Pratik Barai. "Study of fibrinogen levels in patients of acute stroke." International Journal of Research in Medical Sciences 7, no. 1 (2018): 20. http://dx.doi.org/10.18203/2320-6012.ijrms20185356.

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Background: Stroke is a disease of paramount public health significance. The role of plasma fibrinogen in determining incidence and severity of stroke has been postulated time and again. Present study was undertaken to determine the correlation between mean plasma fibrinogen level and infarct volume on CT scan in patients with acute stroke.Methods: Present prospective observational study of two years duration at our tertiary care government centre entailed enrollment and radiological assessment (CT scan/MRI) of 50 consecutive patients with first-ever stroke admitted within 24 h after stroke on

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8

Datta, Shouvik, Mahesh Kumar Mehrotra, and Jasleen Kaur Hura. "Unravelling the Role of Plasma Fibrinogen in Acute Stroke." National Journal of Medical Research 14, no. 03 (2024): 80–84. http://dx.doi.org/10.55489/njmr.14032024999.

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Background: A stroke is described as a sudden neurological deficit with a focused vascular origin. Atrial fibrillation, carotid stenosis, myocardial infarction, hypertension, diabetes, hyperlipidaemia, obesity, smoking and atrial myxomas are all risk factors for stroke. Stroke mortality in urban India accounts for 1% of all hospital admissions, 4% of all medical cases, and around 20% of all central nervous system illnesses. Diabetes, hypertension, smoking, and hyperlipidaemia are risk factors for stroke and have been linked to alterations in haematology and coagulation, including elevated fibr

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Mudjihartini, Ninik. "INFECTIOUS EXACERBATION OF BRONCHIECTASIS SUCCESSFULLY TREATED WITH CEFTRIAXONE/SULBACTAM/DISODIUM EDETATE-1034 (ELORES™)." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 407. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15971.

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Objective: Strokes remain a significant health concern and are the highest cause of mortality and physical or mental disability in productive and the elderly hospitalized patients in Indonesia. Neuroglobin (Ngb) mostly located in the central and peripheral nervous system, predicted enhanced neuronal survival under hypoxic condition, such as in a stroke. The aim of this study is to observe the response of the brain tissue of hemorrhagic stroke patients against hypoxic/ischemic conditions. The objectives are to recognize the pattern of Ngb expression in the brain tissue and plasma of hemorrhagic

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Tarasov, Dmitriy Olegovich, Ilya Arkadievich Lebedev, Sergey Nikolaevich Suplotov, Olga Andreevna Nesterova, Yuliya Viktorovna Boldyreva, and Aleksandr Orestovich Tersenov. "Changes in laboratory parameters of lipid metabolism in HIV patients with cerebral stroke." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 3 (March 3, 2022): 215–21. http://dx.doi.org/10.33920/med-01-2203-05.

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The article reflects the results of assessing the state of the blood lipid spectrum in HIV-positive patients with various types of stroke. Objective: to study laboratory parameters of lipid metabolism in patients with cerebral stroke against the background of HIV infection. Materials and methods. We examined 77 patients with ischemic and 32 patients with hemorrhagic stroke against the background of comorbid HIV infection, who received treatment in hospitals in the Tyumen Region. The study of lipid metabolism parameters was carried out on the Beckman Coulter AU480 analyzer (USA). Blood sampling

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Berger, Daniela, Heinrich Mattle, Bernhard Lämmle, Walter Wuillemin, and Franziska Demarmels Biasiutti. "Hemostatic risk factors in ischemic stroke." Thrombosis and Haemostasis 90, no. 12 (2003): 1094–99. http://dx.doi.org/10.1160/th03-03-0134.

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SummaryThe role played by hemostasis in the pathogenesis of ischemic stroke is still controversial. In the present study, we looked for a possible association of ischemic stroke and high clotting activity of factor II (FII:C), factor V (FV:C), factor VII (FVII:C), factor X (FX:C) and fibrinogen. We investigated 157 non-anti-coagulated patients (86 males, 71 females; median age 41 y, range 16-73 ), who had survived ischemic stroke for at least 2 months, and 193 healthy controls with similar age and sex distribution (104 males, 89 females; median age 39 y, range 19-74). Patients showed significa

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Zhu, Juehua, Li Wang, Han Shao, et al. "Higher Plasma Fibrinogen Level at Admission Is Associated with Post-Stroke Depression at Discharge." Brain Sciences 12, no. 8 (2022): 1032. http://dx.doi.org/10.3390/brainsci12081032.

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Background: Post-stroke depression (PSD) is a common complication of stroke, which seriously affects the functional outcome of patients. Systemic low-grade inflammation associated with PSD has been shown to occur at several months to years, however, whether these inflammatory markers predicted PSD at an acute stage of stroke is controversial. Method: A total of 625 patients with acute ischemic stroke (219 female, 35.40%) were included in this study. PSD was diagnosed using the 17-item Hamilton depression scale (HAMD) at 7 days following discharge (7–14 days after stroke onset). Multivariable l

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Spiegelenberg, Janneke, Mark Roest, Bas De Laat, et al. "Hemostasis Biomarkers and Long-Term Risk of Recurrent Cardiovascular Events and Bleeding Complications in Young Patients with an Ischemic Stroke." Blood 142, Supplement 1 (2023): 2645. http://dx.doi.org/10.1182/blood-2023-187152.

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Background: Patients with ischemic stroke at a young age (18-50 years) have a persistent increased risk of recurrent ischemic cardiovascular events, despite antithrombotic treatment. Additionally, antithrombotic agents result in a higher risk of bleeding complications. Balancing hemostasis to prevent thrombotic events and minimizing the risk of hemorrhagic events is challenging. Previous research observed a hypercoagulable state and a significant degree of inflammation years after an acute ischemic stroke in young adults. It is known that an increased clotting tendency is a risk factor for a f

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Adewolu, O. F., and F. Odiase. "Plasma electrolytes, osmolality and lipid profile in patients with acute stroke in a tertiary hospital in South-South, Nigeria." African Journal of Tropical Medicine and Biomedical Research 7, no. 1 (2025): 22–29. https://doi.org/10.4314/ajtmbr.v7i1.3.

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Introduction stroke or cerebrovascular accident is a leading cause of morbidity and mortality worldwide. Electrolyte imbalances and dyslipidemia cause poor patients' treatment outcomes. Aim of the study wasto evaluate Plasma electrolytes, osmolality and lipid profile in stroke patients. Materials and Method: This was a descriptive cross-sectional study conducted between May 2022 to October 2022, on 144 stroke patients seen in the University of Benin Teaching Hospital. serum electrolytes, Osmolality and lipid profile were assayed. statistical analysis was done using sPss version 22. Level of si

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Azimov, A. T., G. S. Rakhimbaeva, and F. Z. Azimov. "Anticoagulant therapy for stroke prevention in patients with severe COVID-19." Neurology, Neuropsychiatry, Psychosomatics 13, no. 5 (2021): 20–25. http://dx.doi.org/10.14412/2074-2711-2021-5-20-25.

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During the pandemic of the new coronavirus infection, there is increasing evidence of neurological complications associated with COVID-19. There is no doubt that stroke can be a major complication in patients with severe disease course.Objective: to determine the safest and most effective anticoagulant for stroke prevention in patients with severe COVID-19.Patients and methods. A prospective study enrolled 520 patients with severe COVID-19. We used the following criteria for severe COVID-19: SpO2 <92% on room air at sea level, PaO2 /FiO2 <300 mm Hg, respiratory rate >30 breaths/min, l

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Swarowska, Marta, Aleksandra Janowska, Agnieszka Polczak, et al. "The Sustained Increase of Plasma Fibrinogen During Ischemic Stroke Predicts Worse Outcome Independently of Baseline Fibrinogen Level." Inflammation 37, no. 4 (2014): 1142–47. http://dx.doi.org/10.1007/s10753-014-9838-9.

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Feng, Jun, Xue-min Gao, Hao Zhao, et al. "Ischemic stroke in patients with POEMS syndrome." Blood Advances 4, no. 14 (2020): 3427–34. http://dx.doi.org/10.1182/bloodadvances.2020001865.

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Abstract Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is associated with increased risk for ischemic stroke (IS). Because POEMS syndrome is rare, little is known regarding the underlying mechanism and prognosis for IS in patients in whom it occurs. The medical records of patients with POEMS syndrome were screened between January 2018 and January 2000 at Peking Union Medical College Hospital to identify those with IS. The baseline characteristics, IS features, and patient outcomes were analyzed. Forty-one (8.0%) of 510 POEMS pa

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Ye, Chen, Yanan Wang, Quhong Song, Junfeng Liu, Chenchen Wei, and Ming Liu. "Association Between Coagulation Function and Spontaneous Hemorrhagic Transformation in Acute Ischemic Stroke." Current Neurovascular Research 17, no. 4 (2020): 344–53. http://dx.doi.org/10.2174/1567202617666200514114258.

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Background and Purpose: Hemorrhagic transformation (HT) has an adverse effect on the prognosis of patients with acute ischemic stroke, and it is currently known associated with coagulation system. But the conclusion is not consistent and remains to be identified. The aim of this study was to investigate the association between coagulation function and spontaneous hemorrhagic transformation. Methods: Patients within 7 days from the onset of ischemic stroke who did not receive reperfusion therapy (thrombolysis or endovascular treatment) were included between January 2016 and October 2017. Coagul

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Cushman, Mary, Daniel Jones, Leslie A. Lange, et al. "Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults." Thrombosis and Haemostasis 99, no. 02 (2008): 388–95. http://dx.doi.org/10.1160/th07-08-0523.

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SummaryElevated plasma fibrinogen is a risk factor for cardiovascular disease (CVD), but associations between fibrinogen single nucleotide polymorphisms (SNPs) and disease risk are inconsistent. We investigated whether common (≥ 5% minor allele frequency) variation in the fibrinogen genes (FGA, FGB, FGG) is associated with fibrinogen concentration, carotid artery intima-medial thickness (IMT) and risk of incident myocardial infarction (MI), ischemic stroke and CVD mortality in European-(EA) and African-descent (AA) adults (≥ 65 years) from the Cardiovascular Health Study. TagSNPs were genotype

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POP, Nicolae Ovidiu, Petru Aurel BABEȘ, Larisa Bianca HOLHOȘ, et al. "Assessing the level of infectious and inflammatory factors in acute ischemic stroke in diabetic and non-diabetic patients." Romanian Journal of Medical Practice 16, no. 3 (2021): 370–79. http://dx.doi.org/10.37897/rjmp.2021.3.11.

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Introduction. Stroke is one of the principal leading causes of death globally. In 2005, stroke cause approximate 5.7 million death, 87% of deaths was in low and middle-income countries. Recently period, collecting evidence indicated that inflammation and atherosclerosis play important roles in stroke evolution. Material and method. In this prospective longitudinal observational study including 340 patients with acute ischemic stroke with / without diabetes mellitus we analyzed as main criteria infectious factors, inflammatory factors and biochemical factors. The patients were divided into 2 gr

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Role of Serum HsCRP in Predicting Outcome after One Week in Ischemic Stroke Patients." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 5 (2024): 136–43. https://doi.org/10.5281/zenodo.15431850.

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<strong>Abstract</strong> <strong>Introduction</strong>: A stroke is a medical condition in which poor blood flow to the brain results in cell death. There are two main types of strokes: Ischemic and hemorrhagic. Both results in parts of the brain not functioning properly. CRP is not only a sensitive marker of inflammation but also a novel plasma marker of atherosclerosis in disease. Ischemic brain injury is characterized by acute local inflammation and changes in levels of inflammatory cytokines, such as IL-6, IL-2, IL-10, fibrinogen, ferritin and high sensitivity C reactive protein (hsCRP).

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Choi, Kang-Ho, Ja-Hae Kim, Jae-Myung Kim, et al. "d -dimer Level as a Predictor of Recurrent Stroke in Patients With Embolic Stroke of Undetermined Source." Stroke 52, no. 7 (2021): 2292–301. http://dx.doi.org/10.1161/strokeaha.120.033217.

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Background and Purpose: This study aimed to investigate the value of d -dimer levels in predicting recurrent stroke in patients with embolic stroke of undetermined source. We also evaluated the underlying causes of recurrent stroke according to d -dimer levels. Methods: A total of 1431 patients with undetermined source were enrolled in this study and divided into quartiles according to their baseline plasma d -dimer levels. The primary outcome measure was the occurrence of recurrent stroke (ischemic or hemorrhagic) in the year following the stroke event. Results: The risk of recurrent stroke i

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Ishida, Tomohisa, Takashi Inoue, Kuniyasu Niizuma, et al. "Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives." Cerebrovascular Diseases 49, no. 6 (2020): 639–46. http://dx.doi.org/10.1159/000511627.

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<b><i>Background and Purpose:</i></b> Transfer RNA (tRNA) is a noncoding RNA that delivers amino acids to ribosomes for protein synthesis. tRNA is also involved in cell stress response programs. Oxidative stress induces direct conformational change in tRNA structure that promotes subsequent tRNA fragmentation. Using an antibody against tRNA-specific modified nucleoside 1-methyladenosine (m1A), we can detect tRNA derivatives such as conformationally changed tRNA, tRNA-derived fragments, and mononucleotide-free m1A. Based on these findings, tRNA derivatives may have poten

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Baharuddin, A. B. "The association of BclI gene polymorphism and −/INS;148C/T promoter β fibrinogen with plasma fibrinogen level in acute ischemic stroke". Journal of the Neurological Sciences 333 (жовтень 2013): e246. http://dx.doi.org/10.1016/j.jns.2013.07.954.

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Zhao, Shuang, Hong Zheng, Yawei Du, et al. "The Clinical Efficacy of Ginkgo biloba Leaf Preparation on Ischemic Stroke: A Systematic Review and Meta-Analysis." Evidence-Based Complementary and Alternative Medicine 2021 (December 9, 2021): 1–10. http://dx.doi.org/10.1155/2021/4265219.

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Background. Ginkgo biloba leaf preparations (GLPs) are widely used in ischemic stroke, and uncertainty remains regarding their clinical efficacy. To evaluate systematically the clinical efficacy and safety of GLPs in the treatment of ischemic stroke, we examine evidence from randomized controlled trials (RCTs). Methods. We examine studies published prior to November 2021 that were found from searching the following sources: PubMed, China National Knowledge Infrastructure (CNKI), WANFANG DATA, Chongqing VIP (CQVIP) databases, and Chinese Biomedical Literature (CBM). We evaluated the quality of

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Kirtania, K., A. Khatun, RA Chowdhury, and M. Rukunuzzaman. "Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients." Bangladesh Journal of Medical Biochemistry 9, no. 1 (2018): 27–30. http://dx.doi.org/10.3329/bjmb.v9i1.36151.

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Albumin is a non-glycosylated plasma protein synthesized primarily in the liver. It is a protein involved in the transport of small molecules in the blood and plays a key role in restricting fluid leakage from the vasculature into the tissue. Elevated level of serum albumin is related to haemoconcentration and reduced level is associated with malnutrition and chronic inflammatory diseases representing a negative acute phase protein. This cross sectional study was done to determine the association between admission serum albumin levels and short-term outcome following acute stroke. Consecutive

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Tao, Weiwei, Dan Yu, Gang Wu, Wanfen Wang, and Xiaofei Hu. "The role of red blood cell distribution width to platelet ratio in predicting hemorrhagic transformation after mechanical thrombectomy therapy in acute ischemic stroke patients." Neurology Asia 28, no. 3 (2023): 529–34. http://dx.doi.org/10.54029/2023zhn.

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Objective: Hemorrhagic transformation (HT) is common complication after mechanical thrombectory (MT) for acute ischemic stroke (AIS). To our knowledge, there has been no study on the correlation between baseline red blood cell distribution width (RDW) to platelet ratio (RPR) and HT after MT. Methods: This study recruited 126 AIS patients with anterior or posterior circulation large-vessel occlusion who underwent MT therapy at the Department of Neurology, Taizhou Hospital, Zhejiang province between September 2019 and April 2021. Patients were divided into two groups: patients with HT and those

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Kaufmanova, Jirina, Jana Stikarova, Alzbeta Hlavackova, et al. "Fibrin Clot Formation under Oxidative Stress Conditions." Antioxidants 10, no. 6 (2021): 923. http://dx.doi.org/10.3390/antiox10060923.

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During coagulation, the soluble fibrinogen is converted into insoluble fibrin. Fibrinogen is a multifunctional plasma protein, which is essential for hemostasis. Various oxidative posttranslational modifications influence fibrinogen structure as well as interactions between various partners in the coagulation process. The aim was to examine the effects of oxidative stress conditions on fibrin clot formation in arterial atherothrombotic disorders. We studied the changes in in vitro fibrin network formation in three groups of patients—with acute coronary syndrome (ACS), with significant carotid

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Molnar, Tihamer, Kata Borocz, Timea Berki, et al. "Subacute Elevation of Plasma Level of Caspase-Cleaved Cytokeratin-18 is Associated with Hemorrhagic Transformation and Functional Outcome in Ischemic Stroke." Journal of Stroke and Cerebrovascular Diseases 28, no. 3 (2019): 719–27. http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.015.

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Rumley, Ann, and Gordon D. O. Lowe. "Use Of Fibrinogen and Fibrin D-Dimer in Prediction of Arterial Thrombotic Events." Thrombosis and Haemostasis 82, no. 08 (1999): 667–72. http://dx.doi.org/10.1055/s-0037-1615895.

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IntroductionThere is increasing clinical and laboratory interest in the measurement of both plasma fibrinogen and fibrin D-dimer to predict arterial thrombotic events, such as cardiovascular death, myocardial infarction (MI), stroke, leg ischemia, arterial surgery (e.g., angioplasty, bypass grafting), and postsurgical arterial occlusion. There are several possible reasons for such interest.First, there is substantial evidence from prospective studies that the plasma fibrinogen level is a strong, consistent predictor of such cardiovascular events in people with or without clinically detectable

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Hsia, Carleton JC, and Li Ma. "SOD3-Mimetic As a Complement for Genetic Therapy in Sickle Cell Disease." Blood 132, Supplement 1 (2018): 2355. http://dx.doi.org/10.1182/blood-2018-99-120287.

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Abstract Background and Objectives: Genetic therapy relieves transfusion-dependence in patients 12 years and older with ß-Thalassemia (1) There is an urgent need to develop a complementary approach to genetic therapy for children younger than 12 years of age. The objective of this report is to describe the potential development of an extracellular superoxide dismutase-mimetic (SOD3-mimetic) to relieve sickle cell disease (SCD) children susceptible to stroke from being transfusion-dependent in order to avoid stroke. SanFlow [aka polynitroxylated pegylated hemoglobin (PNPH)], a SOD3-mimetic has

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Vasilyeva, I. N., and V. N. Zinkin. "The value of low-molecular-weight DNA of blood plasma in the diagnostic of the patological processes of different genesis." Biomeditsinskaya Khimiya 59, no. 3 (2013): 358–73. http://dx.doi.org/10.18097/pbmc20135903358.

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The low-molecular-weight DNA appears in blood plasma of irradiated rats, and its content correlates directly with the irradiation dose. Cloning has shown, that enrichment of low-molecular-weight DNA with G+C content and features of its nucleotide sequences point to its ability to form rather stable nucleosomes. DNA obtained after irradiation of rats with principally different doses 8 and 100 Gy differed not only quantitatively, but also by content of the dinucleotides CpG and CpT; this suggests their origin from different sites of genome. For the first time it has been shown that exposure to l

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Kamdar, Aditi, Natalie Rintoul, David F. Friedman, James T. Connelly, Holly Hedrick, and Leslie Raffini. "Comparative Effectiveness of Different Strategies for Monitoring Neonates on Extra Corporeal Membrane Oxygenation (ECMO)." Blood 128, no. 22 (2016): 1007. http://dx.doi.org/10.1182/blood.v128.22.1007.1007.

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Abstract Background: ECMO can be life-savingin patients with cardiac or respiratory failure. Anticoagulation, typically with unfractionated heparin (uFH), is necessary to prevent the ECMO circuit from clotting. However, titrating the intensity of anticoagulation to maintain the balance between preventing thrombotic and hemorrhagic complications remains a challenge for providers. This is particularly true in neonates who are at the highest risk of intracranial hemorrhage, and in whom titrating uFH is notoriously difficult. In order to improve titration of anticoagulation, we instituted Enhanced

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Storozhuk, O. B., I. B. Seleznyova, L. O. Storozhuk, T. M. Platonova, B. G. Storozhuk, and T. V. Dovgalyuk. "Some indicators of hemostasis and mortality from thrombotic complications in patients with CKD stage VD who were treated by programmed hemodialysis (five-year follow-up)." Reports of Vinnytsia National Medical University 25, no. 3 (2021): 409–12. http://dx.doi.org/10.31393/reports-vnmedical-2021-25(3)-10.

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Annotation. Thrombotic complications in patients with stage VD chronic kidney disease (CKD), treated by program hemodialysis is one of the causes of high mortality in this category of patients; its major pathogenetic component proved to be hemostatic system disturbances characterized by systemic activation of blood clotting process leading to the development of thrombophilia. Objective – to study the biochemical molecular markers of hemostasis in patients with stage VD CKD, treated by program hemodialysis, and to determine their long-term effect on the development of thrombotic complications a

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Wang, Chi, Mengyi Zheng, Shuohua Chen, Shouling Wu, and Hao Xue. "ASSOCIATION OF INFLAMMATION AND ATHEROGENIC DYSLIPIDEMIA WITH INCIDENT CARDIOMETABOLIC DIASEASE: A LONGITUDINAL COHORT STUDY." Journal of Hypertension 42, Suppl 1 (2024): e269. http://dx.doi.org/10.1097/01.hjh.0001022264.98015.4d.

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Objective: Inflammation and atherogenic dyslipidemia promote each other establishing a vicious circle. This study aimed to examine their joint association with cardiometabolic disease (CMD) and whether the temporal relationship between them is associated with risk of CMD. Design and method: This study included 78,211 participants without history of cardiovascular disease and diabetes mellitus at baseline in 2006. We categorized the participants into six groups according to their C-reactive protein (CRP, <1,1–3, or >=3 mg/L) level and atherogenic index of plasma (AIP, <-0.08 or >=-0

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Mingot-Castellano, María Eva, María Jose Ariza-Corbo, Álvaro Amo Vázquez de la Torre, et al. "Analysis of Hemorrhagic Phenotype and Cardiovascular Risk of Severe Hemophilia a Carriers and Difference with Female Working Population Control Group." Blood 124, no. 21 (2014): 5048. http://dx.doi.org/10.1182/blood.v124.21.5048.5048.

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Abstract INTRODUCTION: Recent studies in male subjects with haemophilia have described a prevalence of cardiovascular risk factors (CVRF) and cardiovascular events (CVE) similar to the general population. This finding has not been tested in severe haemophilia A carriers so far. We have little information about whether there is a particular bleeding profile in this group and if this tendency is able to modify cardiovascular risk in these women. OBJECTIVES: To evaluate bleeding profile from laboratory and clinical point of view in haemophilia A carriers and working population controls; to define

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Barzallo Burbano, Paola Alejandra, Mar Meijón, Nuria Revilla Calvo, et al. "Idarucizumab for Reversal of Dabigatran: Multicenter Real-World Experience." Blood 138, Supplement 1 (2021): 2134. http://dx.doi.org/10.1182/blood-2021-152962.

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Abstract Introduction: Idarucizumab is a humanized monoclonal antibody fragment that binds to dabigatran and reverses its anticoagulant activity. It has been available in Spain since June 2016 and is indicated for imminent surgery or invasive procedures and life-threatening bleeding. The aim of the study was to describe the actual experience with idarucizumab in different centers in Madrid. Methods: Patients with electronic prescription of idarucizumab between June 2016 and July 2021 were included. Demographic information, comorbidities, laboratory parameters, dabigatran indication, anticoagul

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Lalit, Jain and Hemant Kumar Tilgam. "STUDY OF PLASMA FIBRINOGEN LEVELS IN ACUTE STROKE." August 19, 2022. https://doi.org/10.5281/zenodo.7009746.

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<strong>Background:</strong> Stroke is a disease of paramount public health significance. The role of plasma fibrinogen in determining incidence and severity of stroke has been postulated time and again. Present study was undertaken to determine the correlation between mean plasma fibrinogen level and infarct volume on CT scan in patients with acute stroke. <strong>Methods: Source of data:</strong> Plasma fibrinogen of 50 consecutive patients presenting with acute stroke admitted in Netaji Shubhas Chandra Bose Medical College & Hospital, Jabalpur from March 2019 to August 2020 an

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M’barek, Lamia, Aoming Jin, Yuesong Pan, et al. "A similar effect of fibrinogen on efficacy and safety of tenecteplase versus alteplase in acute ischemic cerebrovascular events (TRACE II) trial." Journal of Translational Internal Medicine, April 18, 2025. https://doi.org/10.1515/jtim-2025-0010.

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Abstract Background and Objectives Hemostasis factors affecting clot patterns, particularly fibrinogen, may influence the effectiveness of intravenous thrombolysis (IVT). We aimed to investigate the impact of differences in fibrinogen plasma levels on the efficacy and safety of tenecteplase versus alteplase in an acute ischemic cerebrovascular events-II (TRACE-II) trial. Methods In a multi-center, prospective, open-label, end-point blinded, randomized, controlled trial. Adults with acute ischemic stroke (AIS) were enrolled. Patients received intravenous tenecteplase (0–25 mg/kg) or alteplase (

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Mirzahosseini, Hossein Karballaei, Nioosha Moradpour, Ehsan Yousefi Mazhin, Atabak Najafi, Amirmahdi Mojtahedzadeh, and Mojtaba Mojtahedzadeh. "Warfarin without Therapeutic Monitoring is a Rodenticide, but this Time it Kills the Patient: A Warfarin Toxicity Case Report." Archives of Anesthesia and Critical Care, February 26, 2025. https://doi.org/10.18502/aacc.v11i2.17972.

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According to the American Association of Poison Control Centers (AAPCC), 761 single exposures to the pharmaceutical warfarin were reported in 2021, accounting for more than 10 percent of anticoagulant cases. The cost and mortality caused by warfarin toxicity are very high and usually incurable and fatal. The most important action in the field of warfarin toxicity is to prevent its occurrence. To emphasize how warfarin toxicity occurs, a case is introduced in this regard. A 61-year-old man is found unconscious with a seizure on the street and transported to the hospital by Emergency Medical Ser

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Theodorou, Aikaterini, Klearchos Psychogios, Odysseas Kargiotis, et al. "Fibrinogen time course in acute ischemic stroke patients treated with intravenous thrombolysis with alteplase or tenecteplase." European Stroke Journal, June 15, 2025. https://doi.org/10.1177/23969873251345387.

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Introduction: Limited data exist on intravenous thrombolysis (IVT) effect on fibrinogen depletion, and on possible associations between low fibrinogen levels and hemorrhagic complications, among acute ischemic stroke (AIS) patients. Patients and methods: We conducted a prospective cohort study evaluating fibrinogen levels prior to IVT and at two prespecified timepoints following IVT end (2 and 24 h). Safety and efficacy outcomes were assessed. Fibrinogen depletion was defined as reduction < 200 mg/dl, or as reduction ⩾ 50% of baseline fibrinogen levels after 2 and 24 h from IVT. Furthermore

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Nguyen, Dinh Toan. "STUDY OF CHANGEMENT OF FIBRINOGEN, HSCRP, VS AND INFARCT VOLUME IN PATIENT WITH ACUTE ISCHEMIC STROKE." Journal of Medicine and Pharmacy, January 2017, 142–48. http://dx.doi.org/10.34071/jmp.2016.6.20.

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Objective: To assess the implication of high-sensitivity C-reactive protein(hs-CRP), fibrinogen and erythrocyte sedimentation rate (ESR) in acute stroke and its correlation with the lesion size, vascular risk factors, and neurological impairment. Methods: We included 90 patients consecutively admitted to Department of Neurology, Central hospital of HUE between May 2016 and Dec 2016, with first-ever stroke within the first 72 hours from onset. The fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate (ESR) were determined in plasma on admission and after 72 hours. The

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Long, Jingfang, Jiahao Chen, Guiqian Huang, et al. "The differences of fibrinogen levels in various types of hemorrhagic transformations." Frontiers in Neurology 15 (July 25, 2024). http://dx.doi.org/10.3389/fneur.2024.1364875.

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IntroductionHemorrhagic transformation (HT) is a serious complication that can occur spontaneously after an acute ischemic stroke (AIS) or after a thrombolytic/mechanical thrombectomy. Our study aims to explore the potential correlations between fibrinogen levels and the occurrence of spontaneous HT (sHT) and HT after mechanical thrombectomy (tHT).MethodsA total of 423 consecutive AIS patients diagnosed HT who did not undergone thrombolysis and 423 age- and sex-matched patients without HT (non-HT) were enrolled. Fibrinogen levels were measured within 24 h of admission after stroke. The cohorts

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Pham, Ly, Sydney O’Connor, Karen Yarbrough, et al. "Abstract TMP22: Intravenous Glyburide Treatment is Associated with Reduced Matrix Metalloproteinase-9 in Human Acute Stroke." Stroke 44, suppl_1 (2013). http://dx.doi.org/10.1161/str.44.suppl_1.atmp22.

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Background: Elevated matrix metalloproteinase-9 (MMP-9) following acute ischemic stroke is associated with blood-brain barrier breakdown and hemorrhagic conversion. Prior retrospective evidence suggests that sulfonylurea use may be associated with reduced risk of hemorrhagic conversion. We hypothesized that sulfonylureas may reduce MMP-9 level in stroke patients. Methods: Using serial plasma samples from six subjects in the Glyburide Advantage in Malignant Edema and Stroke Pilot trial (GAMES-Pilot), we evaluated the level of MMP-9 in human subjects presenting with large hemispheric stroke who

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Lin, Changchun, Hui Pan, Yuan Qiao, Peisheng Huang, Jingjing Su, and Jianren Liu. "Fibrinogen Level Combined With Platelet Count for Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy." Frontiers in Neurology 12 (August 31, 2021). http://dx.doi.org/10.3389/fneur.2021.716020.

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A serious complication of acute ischemic stroke (AIS) after mechanical thrombectomy (MT) is hemorrhagic transformation (HT), which is potentially associated with clinical deterioration. This study examined predictors of HT following MT in AIS patients. Patients with AIS due to large artery occlusion in the anterior circulation, treated with MT and successfully recanalized (modified Thrombolysis in Cerebral Infarction score 2b/3), were studied retrospectively. HT was evaluated by computed tomography (CT) 24 h after MT and was diagnosed and classified into parenchymal hematoma (PH) and hemorrhag

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Wolcott, Zoe, Ayush Batra, Jane Khoury, et al. "Abstract 138: Plasma Soluble ST2 Concentration Predicts Functional Outcome and Hemorrhagic Transformation After Acute Ischemic Stroke." Stroke 48, suppl_1 (2017). http://dx.doi.org/10.1161/str.48.suppl_1.138.

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Introduction: Soluble ST2 (sST2) is a member of the interleukin-1 receptor family that predicts mortality and outcome in cardiovascular disease. We aimed to determine whether baseline sST2 predicts functional outcome after stroke and examined its potential role in hemorrhagic transformation (HT). Methods: We measured plasma sST2 and matrix metalloproteinase-9 (MMP-9) in 646 patients who presented with acute ischemic stroke and were enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network biomarker study. Soluble ST2 and total MMP-9 were measured by ELISA

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Nakajima, Sho, Hiroyuki Kawano, Kazuo Yamashiro, et al. "Post-Treatment Plasma D-Dimer Levels Are Associated With Short-Term Outcomes in Patients With Cancer-Associated Stroke." Frontiers in Neurology 13 (April 4, 2022). http://dx.doi.org/10.3389/fneur.2022.868137.

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Background and ObjectiveHypercoagulability is associated with increased risks of ischemic stroke and subsequent mortality in patients with active cancer. This study investigated the relationships between plasma D-dimer levels after stroke treatment and short-term outcomes in patients with cancer-associated stroke.MethodsThis retrospective, observational, multicenter study analyzed consecutive patients with cancer-associated ischemic stroke. Hypercoagulability was assessed by plasma D-dimer levels before and after stroke treatment. Short-term outcomes were assessed in terms of poor outcomes (a

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Pauillac, Naëiri, Dorothée Faille, Mialitiana Solo Nomenjanahary, et al. "Fibrinogen Depletion Coagulopathy and Hemorrhagic Transformation in Acute Ischemic Stroke Treated With Bridging Therapy." Stroke, May 21, 2025. https://doi.org/10.1161/strokeaha.125.051230.

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BACKGROUND: Hemorrhagic transformation (HT) frequently occurs in acute ischemic stroke patients with a large vessel occlusion undergoing endovascular therapy (EVT), significantly impacting functional outcomes. We aimed to determine whether an early fibrinogen depletion coagulopathy (FDC) was associated with HT following bridging therapy (ie, intravenous thrombolysis [IVT] followed by EVT), and to identify its associated factors. METHODS: We retrospectively analyzed prospectively collected data from 296 patients with acute ischemic stroke with a large vessel occlusion who underwent EVT alone or

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Imtiaz Khan, Imtiaz Khan, Hafiz Muhammad Sajid Jehangir Hafiz Muhammad Sajid Jehangir, Hamza Saeed Khokhar Hamza Saeed Khokhar, Amber Naureen Amber Naureen, Aaz Bashir Butt Aaz Bashir Butt, and Muhammad Salman Ashraf Muhammad Salman Ashraf. "Correlation Between Plasma D-dimer Level and Lesion Volume in Acute Ischemic Stroke." Journal of Cardiovascular Diseases 20, no. 1 (2024). https://doi.org/10.55958/jcvd.v20i1.161.

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INTRODUCTION: Acute stroke has recently become the second leading cause of death and disability worldwide especially in industrialized countries. Epidemiologic studies of stroke in 1970s and 1980s reported that percentage of ischemic stroke 73% to 83%, with hemorrhagic stroke as only 8% to 18% only. Efforts are underway worldwide to establish early diagnosis and improve the clinical outcome once stroke has occurred. Neurological examination is a cost-effective method for initiating a diagnostic evaluation and it often helps localizing a lesion site. Computerized axial tomography (CT) brain is

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Bushnaq, Saif, Atif Zafar, Kempuraj Duraisamy, et al. "Abstract TP224: Interleukin-37 Level is Elevated in Acute Ischemic Stroke." Stroke 48, suppl_1 (2017). http://dx.doi.org/10.1161/str.48.suppl_1.tp224.

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Background: Interleukin-37 (IL-37) is a new member of IL-1 cytokine family with a defined role as a negative feedback inhibitor of pro-inflammatory responses. IL-37 has yet to be evaluated in non-immune neurological diseases like ischemic or hemorrhagic stroke. This study aimed to measure the urine and serum IL-37 levels in patients with acute ischemic stroke. Method: Twelve patients consented for the study. Two sets of serum and urine samples were obtained and analyzed; one upon admission to the hospital, and the second the next morning after overnight fasting. The trends in serum level of IL

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