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Journal articles on the topic 'Hemostasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kumar, Anup, Animesh Agrawal, Kala Kumar Bharani, and Leo Mavely. "Evaluation of Hemostatic Effectiveness in a Standard Swine Hemorrhage Model of Severe Bleeding: A Comparative Study of Chitosan Gauze and Kaolin Gauze." International Journal of Health Technology and Innovation 3, no. 02 (2024): 38–47. https://doi.org/10.60142/ijhti.v3i02.07.

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Hemorrhage remains a critical factor contributing to avoidable fatalities in combat scenarios and civilian emergencies. Significant advancements have been made in managing extremity hemorrhage through tourniquet application, although not all injuries can be effectively treated with this method. In the United States, the Committee on Tactical Combat Casualty Care (CoTCCC) has emphasized the importance of employing hemostatic dressings during initial trauma care as an alternative when tourniquet application is not feasible. Similar recommendations have been adopted globally, highlighting the piv

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Rathod, Dr Rohit Narendra. "Hemostasis in the Surgical Field." EAS Journal of Medicine and Surgery 4, no. 10 (2022): 211–14. http://dx.doi.org/10.36349/easjms.2022.v04i10.003.

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Hemostatic mechanisms are an integral a part of the human physiology. Traditionally divided into intrinsic and extrinsic arms, the coagulation cascade converges, through the interactions of the many various factors, at a standard element—thrombin. As a consequence, variety of various agents is developed to supplement this common, critical step to assist surgical hemostasis. Intraoperative interventions most ordinarily include sutures and heat-generating cautery devices; however, these methods are sometimes insufficient or inappropriate for a selected procedure or anatomic location, resulting i

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3

Kondratiev, M. V., A. S. Petrova, A. S. Gryzunova, et al. "Changes in primary and secondary hemostasis as a predictor of adverse neonatal outcomes in birth asphyxia." Voprosy praktičeskoj pediatrii 18, no. 1 (2023): 103–10. http://dx.doi.org/10.20953/1817-7646-2023-1-103-110.

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The hemostatic system is complex and evolves continuously since gestation and well into the adult years, in a process known as “developmental hemostasis”. This article presents information about the functioning of the hemostatic system in normal and pathological conditions (birth asphyxia) in newborns, reflects fundamental differences in hemostatic functioning during the neonatal period and the possibilities in maintaining normal hemostasis in conditions of physiological deficiency of both clotting factors and the anticoagulant system. The article highlights various methods of diagnosing the h

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B, Nichols, Zbozien R, Nichols A, Hunter J, and Hayes PD. "Remedy Publications LLC., | http://surgeryresearchjournal.com World Journal of Surgery and Surgical Research 2023 | Volume 6 | Article 15001 Physical Modification of a Gelatin Sponge Creates a Very Adhesive, Rapidly Absorbable, Blood-Free Hemostat." World Journal of Surgery and Surgical Research 6, no. 1 (2023): 1–6. http://dx.doi.org/10.25107/2637-4625-v6-id1500.

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Background: An effective hemostat not only needs to stop the bleeding whilst it is held in place but importantly, it must stay there securely during the perioperative recovery phases. As patients move during the recovery period, several forces can act on the hemostat leading to its displacement and possible postoperative hemorrhage. Adhesive hemostats have been developed to prevent this, but many contain human blood components or are prohibitively expensive for widespread use. This study evaluated a physical surface modification of a plain gelatin sponge with no additives (chemical/biologic),

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Parkhisenko, Yuri A., Alexey K. Vorontsov, Evgeniy F. Cherednikov, Sergey V. Barannikov, Anton V. Korsakov, and Vladislav P. Troshin. "Morphological assessment of reparative regeneration of experimental bleeding liver wounds in the treatment of hemostatic agent Surgitamp and granular sorbent Molselect G-50." Journal of Volgograd State Medical University 20, no. 1 (2023): 73–80. http://dx.doi.org/10.19163/1994-9480-2023-20-1-73-80.

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The problem of treating intra-abdominal bleeding in abdominal trauma is one of the most serious in urgent surgery. The most common cause of these hemorrhages is liver damage. For surgical hemostasis, local hemostatics and granular sorbents are becoming increasingly common. The aim of the study was to study in vivo the hemostatic properties and morphological features of the reparative regeneration of simulated bleeding liver wounds during treatment with the hemostatic agent Surgitamp and the sorbent Molselect G-50. The experiments were performed on 30 laboratory animals Chinchilla rabbits. Afte

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Romantsov, Mikhail N., Eugene F. Cherednikov, Aleksandr Anatolevich Glukhov, and Constantine O. Fursov. "New technologies of endoscopic hemostasis in a treatment protocol of patients with gastroduodenal ulcer bleeding." Vestnik of Experimental and Clinical Surgery 11, no. 1 (2018): 16–23. http://dx.doi.org/10.18499/2070-478x-2018-11-1-16-23.

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Relevance of research. Acute gastroduodenal bleeding is remaining a difficult and largely unsolved problem up to day. The fundamental importance in treating this category of patients is an endoscopic hemostasis. The decisive point in this problem is the most stable hemostasis and preventing a recurrence of a hemorrhage. In this regard, the search of new solutions and the development of known methods of treatment of the gastroduodenal ulcer bleeding is an important issue.  Aim of research. To evaluate the effectiveness of the treatment protocol of patients with the gastroduodenal ul

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Misumi, Yoshitsugu, Kouichi Nonaka, and Maiko Kishino. "Endoscopic Image 2 Hours after PuraStat® Application: A Case of Achieving Hemostasis Using PuraStat® for Postgastric Lesion Biopsy Bleeding after Hemostatic Clips Failed." Case Reports in Gastrointestinal Medicine 2023 (July 26, 2023): 1–3. http://dx.doi.org/10.1155/2023/5620348.

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PuraStat® (3D Matrix, Tokyo, Japan) is a novel, self-assembling peptide hemostatic hydrogel that can be used endoscopically. Hemostasis can be physically obtained by covering bleeding points; however, there are no reports of how long PuraStat remains in the upper gastrointestinal tract. Herein, we report a case wherein esophagogastroduodenoscopy (EGD) was performed 2 hours after PuraStat application. A 73-year-old man underwent EGD for evaluation of lesions in the posterior wall of the stomach. A biopsy was then performed on the gastric lesions; however, massive bleeding occurred. A hemostatic

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Budko, E. V., L. M. Yampolsky, D. A. Chernikova, and A. A. Khabarov. "Comparative evaluation of the effectiveness of a local hemostatic agent modified with a bio-organic composition." CARDIOMETRY, no. 18 (May 18, 2021): 100–112. http://dx.doi.org/10.18137/cardiometry.2021.18.100112.

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Constant attention to the study of the experience of using hemostatic products proposed for local bleeding arrest encourages new developments in this field. Modern hemostatics are porous multilayer systems with an inclusion of active coagulants. The results of the assessment of hemostatic activity obtained with the help of clinical and laboratory methods often do not lend themselves to cross-checking and statistical processing, and do not allow us to study objects with different physical and chemical properties. Methods of chemometrics, namely planimetry, allow you to visualize the parameters

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9

Wu, Baofeng, Ruixin Zhang, Chendi Liang, Chengjie Zhang, and Gang Qin. "Study on the Safety of the New Radial Artery Hemostasis Device." Journal of Interventional Cardiology 2022 (April 5, 2022): 1–8. http://dx.doi.org/10.1155/2022/2345584.

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Objective. At present, the use of particular radial hemostatic devices after coronary angiography (CAG) or percutaneous coronary intervention (PCI) has become the primary method of hemostasis. Most control studies are based on the products already on the market, while only a few studies are on the new hemostatic devices. The aim of this study is to compare a new radial artery hemostasis device which is transformed based on the invention patent (Application number: CN201510275446) with TR Band (Terumo Medical) to evaluate its clinical effects. Methods. In a prospective randomized clinical trial

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10

Han, Wenli, and Shige Wang. "Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces." Gels 9, no. 1 (2022): 2. http://dx.doi.org/10.3390/gels9010002.

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Currently, uncontrolled bleeding remains a serious problem in emergency, surgical and battlefield environments. Despite the specific properties of available hemostatic agents, sealants, and adhesives, effective hemostasis under wet and dynamic conditions remains a challenge. In recent years, polymeric hydrogels with excellent hemostatic properties have received much attention because of their adjustable mechanical properties, high porosity, and biocompatibility. In this review, to investigate the role of hydrogels in hemostasis, the mechanisms of hydrogel hemostasis and adhesion are firstly el

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Du, Jian, Jingzhong Wang, Tao Xu, Hai Yao, Lili Yu, and Da Huang. "Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis." Molecules 28, no. 13 (2023): 5264. http://dx.doi.org/10.3390/molecules28135264.

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The development of materials that effectively stop bleeding and prevent wound adhesion is essential in both military and medical fields. However, traditional hemostasis methods, such as cautery, tourniquets, and gauze, have limitations. In recent years, new nanomaterials have gained popularity in medical and health fields due to their unique microstructural advantages. Compared to traditional materials, nanomaterials offer better adhesion, versatility, and improved bioavailability of traditional medicines. Nanomaterials also possess advantages such as a high degree and stability, self-degradat

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Zhuk, S., and V. Vorobey-Vykhivska. "Dynamics of indicators of hemostatic system as prognostic criteria consequences of ART programs." HEALTH OF WOMAN, no. 5(111) (June 20, 2016): 165–70. http://dx.doi.org/10.15574/hw.2016.111.165.

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The article deals with the insurense of haemostatic system on the ART result. The objective: of the study was to establish the relationships between the state of hemostasis in dynamics during the ART program and its results. Patients and methods. The study involved 130 women who underwent infertility treatment through IVF. The dynamics of hemostasis indicators for ART programs is investigated. Results. The trend to a hypercoagulable state in women with failed attempts of IVF is fined. Risk factors ART failure due to hemostasis disorders is established. Conclusions. The evolution of the hemosta

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Bjelović, Miloš, Jaume Ayguasanosa, Robin D. Kim, et al. "A Prospective, Randomized, Phase III Study to Evaluate the Efficacy and Safety of Fibrin Sealant Grifols as an Adjunct to Hemostasis as Compared to Cellulose Sheets in Hepatic Surgery Resections." J Gastrointest Surg 22, no. 11 (2018): 1939–49. https://doi.org/10.1007/s11605-018-3852-4.

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Background Local hemostatic agents have a role in limiting bleeding complications associated with liver resection. Methods In this randomized, phase III study, we compared the efficacy and safety of Fibrin Sealant Grifols (FS Grifols) with oxidized cellulose sheets (Surgicel®) as adjuncts to hemostasis during hepatic resections. The primary efficacy endpoint was the proportion of patients achieving hemostasis at target bleeding sites (TBS) within 4 min (T4) of treatment application. Secondary efficacy variables were time to hemostasis (TTH) at a later time point if re-bleeding occurs and c

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Jin, Huiyang, and Zhengke Wang. "Advances in Alkylated Chitosan and Its Applications for Hemostasis." Macromol 2, no. 3 (2022): 346–60. http://dx.doi.org/10.3390/macromol2030022.

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Chitosan, a natural polysaccharide, has been widely used as a biomaterial, especially for hemostasis. However, hemostatic materials processed from pure chitosan have limited hemostatic effect and are extremely unstable in some cases; chemical modification is therefore needed to improve the hemostatic properties of chitosan. Through chemical reactions with hydroxyl and amino groups in chitosan macromolecules, such as alkylation, carboxylation, quaternization, etc., different groups can be introduced into the repeating units. Moreover, the introduction of different substituents can endow chitosa

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15

Park, Jin-Seok, Byung Wook Bang, Su Jin Hong, et al. "Efficacy of a novel hemostatic adhesive powder in patients with refractory upper gastrointestinal bleeding: a pilot study." Endoscopy 51, no. 05 (2019): 458–62. http://dx.doi.org/10.1055/a-0809-5276.

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Abstract Background A new hemostatic adhesive powder (UI-EWD) has been developed to reduce the high re-bleeding rates associated with the currently available hemostatic powders. The current study aimed to assess the efficacy of UI-EWD as a salvage therapy for the treatment of refractory upper gastrointestinal bleeding (UGIB). Methods A total of 17 consecutive patients who had failed to achieve hemostasis with conventional endoscopic procedures and had undergone treatment with UI-EWD for endoscopic hemostasis in refractory UGIB were prospectively enrolled in the study. We evaluated the success

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Dambayev, G. Ts, A. N. Baikov, Ye V. Semichev, et al. "The intraoperative methods of hemostasis during liver surgeries." Bulletin of Siberian Medicine 10, no. 4 (2011): 89–92. http://dx.doi.org/10.20538/1682-0363-2011-4-89-92.

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This article deals with a short analysis of intraoperative hemostasis in parenchymatous organs by the example of liver. A brief historical survey is given. The hemostatic sutures developed by different formers and the defects of hemostatic sutures are considered. There are some features of instrumental hemostasis, its advantages and disadvantages. The description of the new developed devices on basis of cold plasma, the hemostatic and antiseptic properties of the devices are presented.

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Gantsgorn, E. V., A. V. Safronenko, V. I. Polyakova, et al. "Effectiveness and Safety of Modern Hemostatics Based on Chitosan and Kaolin." Journal Biomed 20, no. 3E (2024): 25–29. http://dx.doi.org/10.33647/2713-0428-20-3e-25-29.

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There exist numerous local hemostatic agents; however, their disadvantages, such as a short shelf life, high cost, lack of antiseptic properties, a single mechanism of action, residual toxicity, etc., require the development of new materials capable of meeting as many requirements for an “ideal” hemostatic as possible. Meanwhile, regardless of the mechanism of injury, the implementation of hemostasis is of crucial importance for eliminating the consequences of acute bleeding until the provision of the necessary medical care. This article discusses the safety and effectiveness of some of the mo

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Kamamoto, Dai, Tokunori Kanazawa, Eriko Ishihara, et al. "Efficacy of a topical gelatin-thrombin hemostatic matrix, FLOSEAL®, in intracranial tumor resection." Surgical Neurology International 11 (February 7, 2020): 16. http://dx.doi.org/10.25259/sni_272_2019.

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Background: Hemostasis plays an important role in safe brain tumor resection and also reduces the risk for surgical complications. This study aimed to evaluate the efficacy of FLOSEAL®, a topical hemostatic agent that contains thrombin and gelatin granules, in brain tumor resections. Methods: We evaluated the hemostatic effect of FLOSEAL by scoring the intensity of bleeding from 1 (mild) to 4 (life threatening). We assessed the rate of success of hemostasis with 100 patients who underwent intracranial tumor resection. We also investigated the duration of the operation, the amount of intra- and

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Chen, Ran, Fanglin Du, and Qipeng Yuan. "Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material." Bioengineering 10, no. 7 (2023): 868. http://dx.doi.org/10.3390/bioengineering10070868.

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Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) by combining high-molecular-weight polysaccharide sodium hyaluronate with carboxymethyl chitosan via hydrogen bonding. SHCFs have rapid liquid absorption performance and can enrich blood cells. They transform into a gel when it they come into contact with blood, and are more easily deg

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Uba, Yuki, Takeshi Ogura, Saori Ueno, et al. "Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique." Journal of Clinical Medicine 12, no. 1 (2022): 79. http://dx.doi.org/10.3390/jcm12010079.

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Introduction: Recently, a novel self-assembling peptide hemostatic gel has become available in Japan. However, the safety and efficacy of this novel self-assembling peptide hemostatic gel remain unclear for bleeding after EST. The aim of this study was to evaluate the safety and efficacy of a novel self-assembling peptide hemostatic gel for bleeding after EST, and to perform a comparison to a conventional endoscopic hemostasis technique. Method: This retrospective study was carried out between January 2019 and October 2022. Patients who developed bleeding associated with EST were enrolled. The

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Ravn, Hanne. "Hemostasis in Pediatric Cardiac Surgery." Seminars in Thrombosis and Hemostasis 43, no. 07 (2017): 682–90. http://dx.doi.org/10.1055/s-0037-1603365.

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AbstractThe majority of children undergoing pediatric cardiac surgery with cardiopulmonary bypass require transfusion of blood products. The management of hemostasis in the pediatric population is challenging, partly due to pronounced alterations in several hemostatic parameters following cardiopulmonary bypass. Despite these marked changes being seen quite often, they are not necessarily an indication for hemostatic interventions. This review summarizes and discusses the available monitoring tests of hemostatic impairment during and following pediatric cardiac surgery. It covers standard labo

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Cherednikov, Evgeniy, Igor Yuzefovich, Yuri Maleev, et al. "The Use of the Hemostatic Agent Zhelplastan in Combination with a Granulated Sorbent in the Treatment of Patients with Mallory-Weiss Syndrome." International Journal of Biomedicine 11, no. 2 (2021): 160–63. http://dx.doi.org/10.21103/article11(2)_oa7.

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Background: Mallory-Weiss syndrome (MWS) is one of the common causes of acute upper gastrointestinal bleeding. The aim of our research was to develop a method for the treatment of MWS, which would improve the efficiency of local hemostasis, reduce the risk of re-bleeding and shorten the treatment time. Methods and Results: The study involved 102 patients with MWS. All patients were divided by random sampling into two groups: the main group (MG) and control group (CG). Patients of both groups were comparable in age, gender, concomitant diseases, type of bleeding, size of bleeding defect, and du

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Hussein, Mohamed, Durayd Alzoubaidi, Miguel-Fraile Lopez, et al. "Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer-related bleeding: multicenter international registry." Endoscopy 53, no. 01 (2020): 36–43. http://dx.doi.org/10.1055/a-1186-5360.

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Abstract Background Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and is associated with a 2 % – 17 % mortality rate in the UK and USA. Bleeding peptic ulcers account for 50 % of UGIB cases. Endoscopic intervention in a timely manner can improve outcomes. Hemostatic spray is an endoscopic hemostatic powder for GI bleeding. This multicenter registry was created to collect data prospectively on the immediate endoscopic hemostasis of GI bleeding in patients with peptic ulcer disease when hemostatic spray is applied as endoscopic monotherapy, dual therapy, or rescue therap

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Lippi, Giuseppe, and Emmanuel J. Favaloro. "Laboratory hemostasis: from biology to the bench." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 7 (2018): 1035–45. http://dx.doi.org/10.1515/cclm-2017-1205.

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AbstractPhysiological hemostasis is an intricate biological system, where procoagulant and anticoagulant forces interplay and preserves blood fluidity when blood vessels are intact, or trigger clot formation to prevent excessive bleeding when blood vessels are injured. The modern model of hemostasis is divided into two principal phases. The first, defined as primary hemostasis, involves the platelet-vessel interplay, whilst the second, defined as secondary hemostasis, mainly involves coagulation factors, damaged cells and platelet surfaces, where the so-called coagulation cascade rapidly devel

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Aly, Mai M., Noor El deen El Hefny, Mohamed F. Ibrahim, and Dina A. Hamad. "Hemostasis disorders in intensive care unit in Assiut University Hospital: a prospective study." Egyptian Journal of Haematology 48, no. 4 (2023): 337–44. http://dx.doi.org/10.4103/ejh.ejh_54_23.

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Abstracts Hemostasis disorders either bleeding or thrombosis that occur in intensive care unit (ICU) are common multifactorial problems that affect morbidity and mortality. Prompt identification and correct management improve ICU patient’s outcome. The aim of this study is to assess the incidence of hemostasis disorders among ICU patients and to establish a relationship between hemostasis disorders and outcome of ICU patients. A total of 350 patients were admitted to ICU during the study period. Hundred were excluded secondary to having one or more exclusion criterion; liver diseases (n=33), r

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Borges-Vilches, Jessica, Claudio Aguayo, and Katherina Fernández. "The Effect on Hemostasis of Gelatin-Graphene Oxide Aerogels Loaded with Grape Skin Proanthocyanidins: In Vitro and In Vivo Evaluation." Pharmaceutics 14, no. 9 (2022): 1772. http://dx.doi.org/10.3390/pharmaceutics14091772.

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Using in vitro and in vivo models, this study investigated the hemostatic potential to control bleeding of both unloaded gelatin-graphene oxide aerogels and the same loaded with proanthocyanidins (PAs) from Vitis vinifera grape skin extract. Our results showed that the physicochemical and mechanical properties of the aerogels were not affected by PA inclusion. In vitro studies showed that PA-loaded aerogels increased the surface charge, blood absorption capacity and cell viability compared to unloaded ones. These results are relevant for hemostasis, since a greater accumulation of blood cells

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Bruckner, Brian A., and Matthias Loebe. "Microporous Polysaccharide Hemosphere Absorbable Hemostat (AristaAH®) in Re-Operative Cardiac Surgical Procedures." Winter 9, no. 2 (2012): 96–98. http://dx.doi.org/10.15420/usc.2012.9.2.96.

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Patients undergoing re-operative cardiac surgical procedures present a great challenge with regard to obtaining hemostasis in the surgical field. Adhesions are ever-present and these patients are often on oral anti-coagulants and platelet inhibitors. As part of a well-planned surgical intervention, a systematic approach to hemostasis should be employed to decrease blood transfusion requirement and improve patient outcomes. Topical hemostatic agents can be a great help to the surgeon in achieving surgical field hemostasis and are increasingly being employed. Our approach, to these difficult pat

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Tanya, Suwat, Saengsome Prajaneh, Piyachat Patcharanuchat, and Sajee Sattayut. "Laser-Mediated Hemostasis for Older Patients Receiving Routine Dental Treatment." Dentistry Journal 13, no. 7 (2025): 315. https://doi.org/10.3390/dj13070315.

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Background/Objective: Laser therapy has gained attention in dental practice to minimize bleeding and enhance blood clot formation. This study aimed to explore the utilization and to compare the clinical efficacy of laser-mediated hemostasis for older patients receiving routine dental treatment. Methods: A prospective observational study was conducted across research networks between October 2023 and August 2024, involving 60 patients aged 50 years and older (average = 63.35 years) at risk of postoperative bleeding following dental treatments. Additionally, laser therapy for hemostasis was sele

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Park, Jin-Seok, Hyung Kil Kim, Yong Woon Shin, Kye Sook Kwon, and Don Haeng Lee. "Novel hemostatic adhesive powder for nonvariceal upper gastrointestinal bleeding." Endoscopy International Open 07, no. 12 (2019): E1763—E1767. http://dx.doi.org/10.1055/a-0982-3194.

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Abstract Background and study aims A new hemostatic adhesive powder (UI-EWD) was developed to reduce high rebleeding rates and technical challenges associated with application of currently available hemostatic powders. The aim of the current study was to assess performance of UI-EWD for nonvariceal upper gastrointestinal bleeding (NVUGIB). Patients and methods A total of 56 consecutive patients that received UI-EWD monotherapy for endoscopic hemostasis due to NVUGIB were retrospectively reviewed. Main study outcomes were success rates with immediate hemostasis and rebleeding within 30 days. Ou

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Chen, Yeyi, Lei Wu, Pengpeng Li, et al. "Polysaccharide Based Hemostatic Strategy for Ultrarapid Hemostasis." Macromolecular Bioscience 20, no. 4 (2020): 1900370. http://dx.doi.org/10.1002/mabi.201900370.

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Starkova, A. V., F. V. Sobin, I. P. Rudakova, N. A. Pulina, N. V. Dozmorova, and V. G. Luzhanin. "The Effect of New Water-soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates on the Hemostasis System <i>In vitro</i>." Drug development & registration 12, no. 4 (2023): 151–55. http://dx.doi.org/10.33380/2305-2066-2023-12-4(1)-1679.

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Introduction. The hemostasis system is a set of functional, morphological and biochemical mechanisms of a living organism that ensure the preservation of the liquid state of the blood, the prevention and stopping of bleeding, as well as the integrity of blood vessels. Anticoagulants and hemostatic agents can significantly change the mechanism of hemostasis. Interest in the synthesis and search for compounds that affect the blood coagulation system remains high. Substances exhibiting anticoagulant and hemostatic effects have been found. The search for compounds among the products of organic syn

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Barg, Assaf, Ulrike Nowak-Göttl, and Gili Kenet. "Hemostasis in the Very Young." Seminars in Thrombosis and Hemostasis 44, no. 07 (2018): 617–23. http://dx.doi.org/10.1055/s-0038-1660852.

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AbstractHemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as “developmental hemostasis,” has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K–dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates. However, increased activity of von Willebrand factor a

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Zhang, Chen, Rui Zeng, Zhencheng Liao, et al. "Bletilla striataMicron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/5820405.

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The human body cannot control blood loss without treatment. Available hemostatic agents are ineffective at treating cases of severe bleeding and are expensive or raise safety concerns.Bletilla striataserve as an inexpensive, natural, and promising alternative. However, no detailed studies on its hemostatic approach have been performed. The aim of this study was to examine the hemostatic effects ofB. striataMicron Particles (BSMPs) and their hemostatic mechanisms. We prepared and characterized BSMPs of different size ranges and investigated their use as hemostatic agent. BSMPs of different size

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Minici, Roberto, Raffaele Serra, Claudio Maglia, et al. "Efficacy and Safety of Axiostat® Hemostatic Dressing in Aiding Manual Compression Closure of the Femoral Arterial Access Site in Patients Undergoing Endovascular Treatments: A Preliminary Clinical Experience in Two Centers." Journal of Personalized Medicine 13, no. 5 (2023): 812. http://dx.doi.org/10.3390/jpm13050812.

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Background: Hemostasis of the femoral arterial access site by manual compression or a vascular closure device is critical to the safe completion of any endovascular procedure. Previous investigations evaluated the hemostatic efficacy at the radial access site of some chitosan-based hemostatic pads. This study aims to assess the efficacy and safety of a new chitosan-based hemostatic dressing, namely Axiostat®, in aiding manual compression closure of the femoral arterial access site in patients undergoing endovascular treatments. Furthermore, the outcomes were compared with evidence on manual co

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Casto, Florencia, Miguel Villaescusa, Ezequiel Jungberg, et al. "Efficacy of topical hemostatic agents in neurosurgery: An experimental study in a rat model." Surgical Neurology International 16 (April 25, 2025): 148. https://doi.org/10.25259/sni_791_2024.

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Background Few studies have compared different topical hemostatic agents in live models or brain tissue, and their doses are not standardized. Little is known about the combined use of these different elements in terms of efficacy and safety, especially in neurosurgery. The objective of this study was to evaluate the efficacy of different topic hemostatic agents used in daily neurosurgical practice in an experimental animal model study. Methods A group of 42 Wistar rats was used. A stereotaxic frame was fixed, and coordinates were determined to locate the bregma. A 3 mm hole was drilled with a

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Su, Wenting, Yi Sun, Sining Lv, Bo He, and Wenzhong Lou. "Rapid Pressure Hemostatic Drug Delivery and Microsystem Design Based on Battlefield Trauma." Journal of Physics: Conference Series 2478, no. 12 (2023): 122071. http://dx.doi.org/10.1088/1742-6596/2478/12/122071.

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Abstract The battlefield rapid pressure hemostatic microsystem maximizes hemostasis efficiency. Battlefield wound has the characteristics of rapid blood loss and irregular surface, which needs to be treated in a very short time. The existing rapid hemostasis method has poor efficiency and no sterilization and disinfection effect. Therefore, we reported a wound pressure hemostatic microsystem based on gas generated by rapid chemical reaction. Before the device is used, the two chemicals in the device are isolated. During hemostasis, the flexible device is applied to the wound surface, and the t

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Jain, Neha. "Evaluation of Different Hemostatic Method in Achieving Hemostasis in Patient on Oral Anticoagulant Therapy." SVOA Dentistry 5, no. 1 (2024): 26–32. http://dx.doi.org/10.58624/svoade.2024.05.0166.

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Patients receiving oral anticoagulant therapy are at an increased risk of bleeding complications, necessitating effective hemostatic interventions. This study aims to evaluate and compare the efficacy of four hemostatic agent (figure of eight suturing, Absorbable gelatin sponge (ABGEL), Topical application of hemocogulase, and pressure gauze pack) in achieving hemostasis among patients on oral anticoagulant therapy. The study was conducted on 100 patients which were randomly divided in four groups and we found that all methods of achieving hemostasis are equally beneficial.

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Al-Zahrani, Faisal M. "New and more effective application assays for hemostatic disorder assessment: A systematic review." Electronic Journal of General Medicine 20, no. 6 (2023): em538. http://dx.doi.org/10.29333/ejgm/13570.

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<b>Background:</b> Hemostasis research lacked novel platform assays for hemostatic disorder diagnosis. The current review study’s goal is to compare various assays for evaluating the novel hemostatic techniques used in the diagnosis of coagulation disturbances and to highlight each method’s strongest and weakest points.<br /> <b>Methods:</b> The PRISMA guidelines and the recommendations for observational studies in epidemiology were both followed in the current systematic review. The PRISMA-compliant electronic databases (PubMed), a novel platform for evaluating h

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Murakami, Takashi, Eiji Kamba, Keiichi Haga, et al. "Emergency Endoscopic Hemostasis for Gastrointestinal Bleeding Using a Self-Assembling Peptide: A Case Series." Medicina 59, no. 5 (2023): 931. http://dx.doi.org/10.3390/medicina59050931.

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Background and Objectives: A novel synthetic self-assembling peptide, PuraStat, has been introduced as a hemostatic agent. This case series aimed to evaluate the clinical efficacy of PuraStat for gastrointestinal bleeding during emergency endoscopy. Cases: Twenty-five patients with gastrointestinal bleeding who had undergone emergency endoscopy with PuraStat between August 2021 and December 2022 were retrospectively examined. Six patients were receiving antithrombotic agents, and ten patients with refractory gastrointestinal bleeding had undergone at least one endoscopic hemostatic procedure.

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Sharma, Saurabh, Tejraj P. Kale, Lingaraj J. Balihallimath, and Abhishek Motimath. "Evaluating Effectiveness of Axiostat Hemostatic Material in achieving Hemostasis and Healing of Extraction Wounds in Patients on Oral Antiplatelet Drugs." Journal of Contemporary Dental Practice 18, no. 9 (2017): 802–6. http://dx.doi.org/10.5005/jp-journals-10024-2130.

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ABSTRACT Aim The aim of this study was to evaluate the efficacy of Axiostat Hemostatic Dental dressing in achieving hemostasis postextraction and determining its effect on pain and healing of the extraction wound, compared with control, i.e., conventional method of extraction in patients on oral antiplatelet therapy. Materials and methods Totally, 40 patients on oral antiplatelet drugs were included in the study and overall 80 extractions were done applying split mouth study design, without altering patient's drug regime. Extraction sites were divided into two groups: Group I received Axiostat

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Chapman, William C., Sherry M. Wren, Gail S. Lebovic, Martin Malawer, Randolph Sherman, and Jon E. Block. "Effective Management of Bleeding during Tumor Resection with a Collagen-Based Hemostatic Agent." American Surgeon 68, no. 9 (2002): 802–7. http://dx.doi.org/10.1177/000313480206800914.

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In a prospective controlled trial hemostatic effectiveness of a novel collagen-based composite (CoStasis®) was compared with a collagen sponge applied with manual pressure at diffusely bleeding sites after surgical tumor resection. The proportion of subjects achieving complete cessation of bleeding within 10 minutes (i.e., hemostatic success) and the time to “complete hemostasis” were determined at raw surgical sites after tumor resection among 23 experimental and 30 control subjects. There was a similar distribution in tumor types (e.g., benign vs malignant) evaluated between treatment groups

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Reshetnyak, V. I., I. V. Maev, T. M. Reshetnyak, S. V. Zhuravel, and V. M. Pisarev. "Liver Diseases and the Hemostasis (Rewiew) Part 1. Non-Cholestatic Diseases of the Liver and Hemostasis." General Reanimatology 15, no. 5 (2019): 74–87. http://dx.doi.org/10.15360/1813-9779-2019-5-74-87.

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In liver diseases, most commonly in the terminal stage of liver failure, a variety of hemostatic defects affecting almost all parts of the blood coagulation system are developing. This leads to diminishing the capabilities of patients with liver diseases to correctly maintain the hemostatic balance.The severity of hemostatic disorders depends on the nosological form and degree of a liver damage. Depending on the imbalance of the hemostasis system and accumulated clinical/laboratory data, patients with liver diseases can be subdivided into three groups as exhibiting: 1. non-cholestatic liver da

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Ali-Mohamad, Nabil, Massimo Cau, James Baylis, et al. "Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study." Endoscopy International Open 09, no. 05 (2021): E693—E698. http://dx.doi.org/10.1055/a-1374-5839.

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Abstract Background and study aims Hemostatic powders have emerged recently to treat upper gastrointestinal bleeding (UGIB). Previously, we developed a novel self-propelling thrombin powder (SPTP) that effectively manages external pulsatile arterial bleed without compression, by effervescing and carrying thrombin into the wound. Here, we tested if SPTP, sprayed endoscopically, can manage severe UGIB in a live porcine model. Materials and methods Anesthetized pigs underwent laparotomy to insert the gastroepiploic vascular bundles into the stomach lumen via a gastrotomy. Bleeding was initiated e

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Kontovazainitis, Christos-Georgios, Dimitra Gialamprinou, Theodoros Theodoridis, and Georgios Mitsiakos. "Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests." Diagnostics 14, no. 3 (2024): 347. http://dx.doi.org/10.3390/diagnostics14030347.

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Pre-eclampsia (PE) is a placenta-mediated disease and remains a major cause of maternal and neonatal mortality and morbidity. As PE develops, normal pregnancy’s hypercoagulable balance is disrupted, leading to platelet hyperactivation, excessive pathological hypercoagulability, and perturbed fibrinolysis. This narrative review aims to summarize the current knowledge regarding hemostasis in PE compared with healthy gestation and the potential effects of maternal PE on neonatal hemostasis. Finally, it aims to discuss hemostasis assessments for normal pregnancies and PE, emphasizing the role of v

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Toubi, Elias, and Zahava Vadasz. "Hemostasis in Allergy." Seminars in Thrombosis and Hemostasis 44, no. 07 (2018): 669–75. http://dx.doi.org/10.1055/s-0038-1648232.

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AbstractThe involvement of the hemostatic system in immune-mediated inflammation is widely reported. Many coagulation factors play a role in the pathogenesis of autoimmune diseases, such as systemic vasculitis and systemic lupus erythematosus. Hemostatic disorders are also involved in asthma and chronic spontaneous urticaria (CSU). Factor XIIa (FXIIa) was one of the first coagulation factors implicated in inducing both humoral and cellular responses and is therefore considered a prime new therapeutic target in immune-mediated inflammation. The involvement of coagulation factors, such as tissue

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Fan, Peng, Yanbo Zeng, Dionisio Zaldivar-Silva, Lissette Agüero, and Shige Wang. "Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects." Molecules 28, no. 3 (2023): 1473. http://dx.doi.org/10.3390/molecules28031473.

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The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels an

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Kostko, N. A., and G. M. Kostin. "THE SYSTEM OF HEMOSTASIS FOR POLICYTHEMIA AND CHRONIC MYELOLEUKOSIS." Health and Ecology Issues, no. 4 (December 28, 2006): 56–62. http://dx.doi.org/10.51523/2708-6011.2006-3-4-10.

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It has been discovered that for chronic myeloleukosis and policythemia changes of a hemostasis are typical at those stage where directly participates platelet component, namely at the final stage of a blood clot formation and at a level of a platelet hemostasis. We demonstrate: on the background of normal or increased platelets level, saved based secondary hemostasis tests, the combination of hyperfibrinolysis, decrease in a clot volume, its density and a general hemostatic parameter results in functionally defective blood clot formation, which, in its turn, testifies about hemorrhagic risk.

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Adili, Reheman, Madeline Jackson, Livia Stanger, et al. "Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice." Clinical and Applied Thrombosis/Hemostasis 27 (January 1, 2021): 107602962110185. http://dx.doi.org/10.1177/10760296211018510.

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Uncontrolled bleeding associated with trauma and surgery is the leading cause of preventable death. Batroxobin, a snake venom-derived thrombin-like serine protease, has been shown to clot fibrinogen by cleaving fibrinopeptide A in a manner distinctly different from thrombin, even in the presence of heparin. The biochemical properties of batroxobin and its effect on coagulation have been well characterized in vitro. However, the efficacy of batroxobin on hemostatic clot formation in vivo is not well studied due to the lack of reliable in vivo hemostasis models. Here, we studied the efficacy of

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Hwang, Yeok Gu, Jin Woo Lee, Eun Ae Won, and Seung Hwan Han. "Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatient Clinic." Journal of Diabetes Research 2019 (November 11, 2019): 1–6. http://dx.doi.org/10.1155/2019/9316380.

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Background. The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods. A prospective, randomized, clinical trial study was performed in twenty-six patients with diabetic foot ulcers who take an anticoagulant requiring minor debridement in an outpatient clinic. Minor debridement and removal of break down skin were performed by one orthopedic surgeon. Hemostasis on wound bed was achiev

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Matsubara, Makoto, Masataka Banshodani, Akira Takahashi, et al. "Vascular access management after percutaneous transluminal angioplasty using a calcium alginate sheet: a randomized controlled trial." Nephrology Dialysis Transplantation 34, no. 9 (2018): 1592–96. http://dx.doi.org/10.1093/ndt/gfy143.

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Abstract Background Management of vascular access (VA) is essential in hemodialysis (HD) patients. However, VA often fails and percutaneous transluminal angioplasty (PTA) is required. Conventional hemostasis at the puncture site is associated with complications. This study aimed to analyze the efficacy and safety of a hemostatic wound dressing made of calcium alginate at the puncture site of VA after PTA and evaluate other factors affecting hemostasis. Methods After PTA for VA, 200 HD patients were randomized to a calcium alginate sheet (CA) group (n = 100) or a no drug-eluting sheet (control)

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