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Journal articles on the topic 'Hemostatic mateial'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

B, Nichols, Zbozien R, Nichols A, Hunter J, and Hayes PD. "Remedy Publications LLC., | http://surgeryresearchjournal.com World Journal of Surgery and Surgical Research 2023 | Volume 6 | Article 15001 Physical Modification of a Gelatin Sponge Creates a Very Adhesive, Rapidly Absorbable, Blood-Free Hemostat." World Journal of Surgery and Surgical Research 6, no. 1 (2023): 1–6. http://dx.doi.org/10.25107/2637-4625-v6-id1500.

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Background: An effective hemostat not only needs to stop the bleeding whilst it is held in place but importantly, it must stay there securely during the perioperative recovery phases. As patients move during the recovery period, several forces can act on the hemostat leading to its displacement and possible postoperative hemorrhage. Adhesive hemostats have been developed to prevent this, but many contain human blood components or are prohibitively expensive for widespread use. This study evaluated a physical surface modification of a plain gelatin sponge with no additives (chemical/biologic),

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Ribalta, Teresa, Ian E. McCutcheon, Antonio G. Neto, et al. "Textiloma (Gossypiboma) Mimicking Recurrent Intracranial Tumor." Archives of Pathology & Laboratory Medicine 128, no. 7 (2004): 749–58. http://dx.doi.org/10.5858/2004-128-749-tgmrit.

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Abstract Context.—Resorbable substances used to achieve hemostasis during neurosurgical procedures comprise 3 principal classes based on chemical composition: (1) gelatin sponge, (2) oxidized cellulose, and (3) microfibrillar collagen. Nonresorbable hemostatic aides include various forms of cotton and rayon-based hemostats (cottonoids and kites). Resorbable and nonresorbable hemostatic agents have been reported to cause symptomatic mass lesions, most commonly following intra-abdominal surgery. Histologic examination typically shows a core of degenerating hemostatic agent surrounded by an infla

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Chen, Ran, Fanglin Du, and Qipeng Yuan. "Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material." Bioengineering 10, no. 7 (2023): 868. http://dx.doi.org/10.3390/bioengineering10070868.

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Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) by combining high-molecular-weight polysaccharide sodium hyaluronate with carboxymethyl chitosan via hydrogen bonding. SHCFs have rapid liquid absorption performance and can enrich blood cells. They transform into a gel when it they come into contact with blood, and are more easily deg

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Wang, Qinghua, Jingwei Chen, Dexiang Wang, et al. "Rapid Hemostatic Biomaterial from a Natural Bath Sponge Skeleton." Marine Drugs 19, no. 4 (2021): 220. http://dx.doi.org/10.3390/md19040220.

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Uncontrolled bleeding is the main cause of mortality from trauma. Collagen has been developed as an important hemostatic material due to its platelet affinity function. A bath sponge skeleton is rich in collagen, also known as spongin. To understand the hemostatic effect of spongin, spongin materials, SX, SFM and SR were prepared from the bath sponge Spongia officinalis, and hemostatic experiments were performed. The SX, SFM and SR were significantly better than the positive control, type I collagen, in shortening the whole blood clotting time in vitro and hemostasis upon rat tail amputation.

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Sharma, Saurabh, Tejraj P. Kale, Lingaraj J. Balihallimath, and Abhishek Motimath. "Evaluating Effectiveness of Axiostat Hemostatic Material in achieving Hemostasis and Healing of Extraction Wounds in Patients on Oral Antiplatelet Drugs." Journal of Contemporary Dental Practice 18, no. 9 (2017): 802–6. http://dx.doi.org/10.5005/jp-journals-10024-2130.

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ABSTRACT Aim The aim of this study was to evaluate the efficacy of Axiostat Hemostatic Dental dressing in achieving hemostasis postextraction and determining its effect on pain and healing of the extraction wound, compared with control, i.e., conventional method of extraction in patients on oral antiplatelet therapy. Materials and methods Totally, 40 patients on oral antiplatelet drugs were included in the study and overall 80 extractions were done applying split mouth study design, without altering patient's drug regime. Extraction sites were divided into two groups: Group I received Axiostat

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Nabavizadeh, Mohammad Reza, Arman Zargaran, Fariborz Moazami, et al. "Comparison of the Hemostatic Activity of Quercus persica Jaub. & Spach. (Oak) With Ferric Sulfate in Bony Crypts." Journal of Evidence-Based Complementary & Alternative Medicine 21, no. 1 (2015): 34–38. http://dx.doi.org/10.1177/2156587215593378.

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Effective tissue hemostasis in periapical surgical site is important in the procedures. Plants with large amount of tannins may act as a local hemostatic agent. We aimed to compare the hemostatic effect of the extract of Quercus persica with one of the common hemostatic material used in periapical surgery. Six standardized bone holes were prepared in the calvaria of 5 Burgundy rabbits. Two hemostatic medicaments were tested for their hemostatic effect and were compared with control defects: Group 1, cotton pellet soaked in 15.5% ferric sulfate solution; Group 2, cotton pellet soaked in pure et

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Zhang, Shiyao, Tingting Shi, Guangjun Wu, Qi Zhang, and Pibo Ma. "Preparation and property of soluble hemostatic material with 3D knitted structure." Journal of Industrial Textiles 52 (August 2022): 152808372211073. http://dx.doi.org/10.1177/15280837221107399.

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To solve the problems of low mechanical properties and poor coagulation effect of soluble hemostatic dressings, a new type of soluble hemostatic fabric with three-dimensional knitted structure is proposed in this paper. Three-dimensional knitted fabrics had good extension and porous structure. This three-dimensional soluble knitted fabric can be used for skin wounds clotting and healing. This paper mainly studied the influence of structural thickness on the performance of three-dimensional knitted dressings. Characterization analysis showed that three-dimensional knitted soluble hemostatic dre

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Zhang, Wanli, Junqin Mao, Aiping Yang, et al. "A Biomimetic Adhesive/Kaolin Material with Strong Adhesion, Sealing, and Active Coagulation Function for Arterial Hemostasis." International Journal of Molecular Sciences 26, no. 10 (2025): 4688. https://doi.org/10.3390/ijms26104688.

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Effective prehospital hemostasis is pivotal for improving survival outcomes in arterial hemorrhage. Existing hemostatic materials have limitations in terms of both efficiency and portability, particularly under complex wound conditions. This study engineered a kaolin-reinforced biomimetic adhesive composite powder (DTG-K), which achieved dual hemostatic mechanisms: mechanical occlusion via strong interfacial adhesion (lap-shear strength of 58.3 kPa) and biochemical activation of the intrinsic coagulation pathway through factor XII. In vitro evaluations confirmed its exceptional hemocompatibili

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Lin, Xiangwei, Yajing Shen, and Lidai Wang. "Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge." Nanomaterials 11, no. 11 (2021): 2879. http://dx.doi.org/10.3390/nano11112879.

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Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleedi

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Kerbl, Kurt, and Ralph V. Clayman. "Acute Hemostasis During Laparoscopic Procedures: Method for Intraoperative Application of Hemostatic Material." Journal of Urology 151, no. 1 (1994): 109–10. http://dx.doi.org/10.1016/s0022-5347(17)34883-8.

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Li, Lin, Yan Du, Yi Xiong, et al. "Injectable negatively charged gelatin microsphere-based gels as hemostatic agents for intracavitary and deep wound bleeding in surgery." Journal of Biomaterials Applications 33, no. 5 (2018): 647–61. http://dx.doi.org/10.1177/0885328218807358.

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Gelatin, as natural macromolecular material, has been used in biomedical fields widely. In this study, various injectable gelatins A, B, and their compound AB microsphere-based gels (A-GMGs, B-GMGs and AB-GMGs) were prepared through water-in-oil emulsion method for hemostasis, and the effects of blood coagulation in vitro and surgical hemostasis (a deep liver wound model) in vivo were evaluated. Furthermore, the influences of gelatin sorts, the size of microsphere, zeta potential (ZP) and viscoelastic properties on hemostasis were also assessed. Results showed that the gelatin microspheres (GM

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Chen, Zihao, Lei Han, Changjun Liu, et al. "A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan." Nanoscale 10, no. 43 (2018): 20234–45. http://dx.doi.org/10.1039/c8nr07865c.

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Due to the designed, coagulation-promoting microstructure, a rapid and safe hemostat was developed and its hemostatic efficiency was evaluated by in vitro clotting tests and in vivo hemostatic analyses.

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Chen, Yeyi, Lei Wu, Pengpeng Li, et al. "Polysaccharide Based Hemostatic Strategy for Ultrarapid Hemostasis." Macromolecular Bioscience 20, no. 4 (2020): 1900370. http://dx.doi.org/10.1002/mabi.201900370.

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Tigchelaar, Izaak, Stefan Monnink, Johan Haan, Noriyuki Tabuchi, and Willem Van Oeveren. "Platelet Function Analysis After In Vitro Treatment with Hemostasis-Affecting Components." Seminars in Thrombosis and Hemostasis 21, S 02 (1995): 71–76. http://dx.doi.org/10.1055/s-0032-1313606.

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An overall platelet function test in whole blood, which simulates conditions under arterial pressure, is useful in measuring the effect of polymer materials on blood hemostatic function. We performed biocompatibility tests with materials or plasma substitutes by interaction of blood from healthy volunteers and then subjected these blood samples to platelet function analysis (Thrombostat). We tested also the capacity of locally applied hemostatic agents for bleeding control by direct application of these agents onto the Thrombostat measuring cell. The biocompatibility tests with materials expos

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Stenson, Katherine M., Ian M. Loftus, Ian Chetter, et al. "A Multi-Centre, Single-Arm Clinical Study to Confirm Safety and Performance of PuraStat®, for the Management of Bleeding in Elective Carotid Artery Surgery." Clinical and Applied Thrombosis/Hemostasis 28 (January 2022): 107602962211443. http://dx.doi.org/10.1177/10760296221144307.

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Anastomotic bleeding in vascular surgery can be difficult to control. Patients, in particular those undergoing carotid surgery, have often been started on treatment with dual antiplatelet agents and receive systemic heparinization intraoperatively. The use of local hemostatic agents as an adjunct to conventional methods is widely reported. 3-D Matrix’s absorbable hemostatic material RADA16 (PuraStat®), is a fully synthetic resorbable hemostatic agent. The aim of this study is to confirm the safety and performance of this agent when used to control intraoperative anastomotic bleeding during car

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Zuk, I. G., P. M. Lozhko, V. V. Kudlo, T. S. Gushcha, and Yu M. Kiselevskiy. "ANATOMICAL AND EXPERIMENTAL REASONING OF LIVER RESECTION USING HYDRODISSECTION TECHNIQUE." Hepatology and Gastroenterology 7, no. 1 (2023): 37–42. http://dx.doi.org/10.25298/2616-5546-2023-7-1-37-42.

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Background. Due to an increasing number of liver surgery, the problems of using secure hemostatic techniques during its resection are still relevant and require further study. Objective. To determine the optimal technique of local hemostasis during liver resection based on a comparative morphological assessment of the liver wound. Material and methods. The study was performed on 30 outbred white rats using local hemostatic techniques with further morphological examination of biological material on 7th and 21st days. Results. It has been established that cryohemostasis, electrocoagulation and l

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Tucci, Michelle, Drew Hildebrandt, Joseph Lichtenhan, and Hamed Benghuzzi. "Evaluation of Full Thickness Wounds Following Application of a Visco-Liquid Hemostat in a Swine Model." Pathophysiology 31, no. 3 (2024): 458–70. http://dx.doi.org/10.3390/pathophysiology31030034.

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Wound healing is a complex dynamic biomechanical process as the body attempts to restore the integrity of traumatized or devitalized tissues. There are four stages of wound of healing that begins with hemostasis followed by inflammation, proliferation and finally weeks later wound remodeling. Full thickness wounds usually are covered with a dressing material after hemostasis, which allows for controlled hydration. We investigated the potential of a visco-liquid hemostat, polyhedral oligomeric silsesquioxane (POSS), for providing hemostasis and to maintain a microenvironment in the wound bed th

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Hwang, Yeok Gu, Jin Woo Lee, Eun Ae Won, and Seung Hwan Han. "Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatient Clinic." Journal of Diabetes Research 2019 (November 11, 2019): 1–6. http://dx.doi.org/10.1155/2019/9316380.

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Background. The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods. A prospective, randomized, clinical trial study was performed in twenty-six patients with diabetic foot ulcers who take an anticoagulant requiring minor debridement in an outpatient clinic. Minor debridement and removal of break down skin were performed by one orthopedic surgeon. Hemostasis on wound bed was achiev

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Lipatov, V. A., S. V. Lazarenko, A. V. Ivanov, D. A. Severinov, A. A. Denisov, and A. E. Kovaleva. "Study of liver tissue with topical application of new spongy hemostatic agents in experiment." Experimental and Clinical Gastroenterology, no. 11 (November 17, 2024): 119–27. https://doi.org/10.31146/1682-8658-ecg-231-11-119-127.

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Research Objective: To study the histological features of the reaction of liver tissue in an in vivo experiment when modeling various types of liver damage and using new samples of local hemostatic agents Materials and methods. The research materials used were samples of new spongy polymer hemostatic agents (based on marine collagen, in different weight ratios with sodium salt of carboxymethylcellulose (three types of samples containing 15%, 25%, 50% collagen), as well as products used in clinical practice - hemostatic collagen sponge, Tachocomb collagen plate. The reaction of liver tissues to

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Krishnegowda, Sahadev Chickmagravalli, Bharath Makonahalli Jaganath, Sandeep Rudranaik, and Amritha Bhat Harnad. "Comparative Evaluation of the Effect of 25% Aluminum Chloride Solution, Chitosan Hemostatic Dressing, and 980 nm Diode Laser on the Pushout Bond Strength of Angelus Bio C-Repair Material: An In vitro Study." Journal of Interdisciplinary Dentistry 14, no. 2 (2024): 97–101. http://dx.doi.org/10.4103/jid.jid_3_24.

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Background: To evaluate and compare the effect of 25% aluminum chloride solution, chitosan hemostatic dressing, and 980 nm diode laser on the pushout bond strength of Angelus Bio C-Repair when used as a furcal perforation repair material. Materials and Methods: Forty extracted human maxillary molars were collected, with 10 teeth in each group. Furcal perforations were simulated and were contaminated with human blood, except for one group. The contaminated groups were treated with 25% aluminum chloride, chitosan hemostatic dressing, and 980 nm diode laser, or none at all. All the perforations w

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Zhu, Xulong, Jianxiong Wang, Shuhan Wu, et al. "Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material." Mediators of Inflammation 2022 (August 10, 2022): 1–8. http://dx.doi.org/10.1155/2022/4083477.

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Degradable hemostatic materials have unique advantages in reducing the amount of bleeding, shortening the surgical operation time, and improving patient prognosis. However, none of the current hemostatic materials are ideal and have disadvantages. Therefore, a novel biodegradable cellulose-based composite hemostatic material was prepared by crosslinking sodium carboxymethyl cellulose (CCNa) and hydroxyethyl cellulose (HEC), following an improved vacuum freeze-drying method. The resulting cellulose composite material was neutral in pH and spongy with a density of 0.042 g/cm3, a porosity of 77.6

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Suchý, Pavel, Alice Paprskářová, Marta Chalupová, et al. "Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate." Materials 13, no. 7 (2020): 1627. http://dx.doi.org/10.3390/ma13071627.

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The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were int

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Zhang, Xiaojian, Kaili Dai, Chenyu Liu, et al. "Berberine-Coated Biomimetic Composite Microspheres for Simultaneously Hemostatic and Antibacterial Performance." Polymers 13, no. 3 (2021): 360. http://dx.doi.org/10.3390/polym13030360.

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Biomimetic microspheres containing alginate/carboxymethylcellulose/gelatin and coated with 0%, 1%, 3%, and 6% berberine (BACG, BACG-1B, BACG-3B, BACG-6B) were prepared by the oil-in-water emulsion method combined with spray drying. Through a series of physicochemical parameters and determination of hemostatic properties in vitro and in vivo, the results indicated that BACG and BACG-Bs were effective in inducing platelet adhesion/aggregation and promoting the hemostatic potential due to their biomimetic structure and rough surface. In addition, BACG-6B with high berberine proportion presented b

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Ilie-Ene, Alexandru, Victor Petru Tosa, Luciana-Madalina Gherman, et al. "New Biocompatible Cyanoacrylate and Polylactic Acid Hemostatic Patch: An In Vivo Proof of Concept Study." Materials 18, no. 6 (2025): 1271. https://doi.org/10.3390/ma18061271.

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Background: Traumatic injuries cause millions of deaths annually, with intra-abdominal hemorrhage as a leading cause. Achieving hemostasis remains challenging. This study evaluates the hemostatic properties of a novel biocompatible cyanoacrylate–polylactic acid patch. Methods: Thirty-six male Wistar rats were randomized into three groups (control, study, and TachoSil®) and underwent a standardized liver resection. The hemostasis times were recorded, and blood samples were drawn to assess hemoglobin, hematocrit, and cytokine levels (IL-6 and TNF-α) using validated assays. Results: In the study

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Shin, Mikyung, Jae Hyuk Choi, Keumyeon Kim, Soomi Kim, and Haeshin Lee. "Hemostatic Needles: Controlling Hemostasis Time by a Catecholamine Oxidative Pathway." ACS Applied Materials & Interfaces 13, no. 9 (2021): 10741–47. http://dx.doi.org/10.1021/acsami.0c22223.

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Kadyseva, Oksana Vladimirovna, Vladimir Nikolaevich Bykov, Olga Yurievna Strelova, and Alexander Nikolaevich Grebenyuk. "Determination of indicators allowing to evaluating the hemostatic activity of chitosan without a biological experiment." Journal of Bioactive and Compatible Polymers 36, no. 4 (2021): 276–82. http://dx.doi.org/10.1177/08839115211030607.

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The biopolymer chitosan is widely used for the development of local hemostatic agents. However, the physicochemical parameters of chitosan that determine its hemostatic properties have not yet been determined. Standard quality control of chitosan-containing raw materials and medical products on its basis do not allow us to make a conclusion about the effectiveness of their use for stopping bleeding. The most reliable method for assessing hemostatic activity remains in vivo experiment on large animals. The aim of this study was to determine additional physicochemical parameters of chitosan, whi

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Leng, Fan, Jie Liu, Enfu Du, et al. "Recent progress in polysaccharide microsphere-based hemostatic material for intravascular and extravascular hemostasis: A review." International Journal of Biological Macromolecules 300 (April 2025): 140280. https://doi.org/10.1016/j.ijbiomac.2025.140280.

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Jovanovic, Milan, Goran Stanojevic, Jovica Jovanovic, and Miroslav Stojanovic. "Splenic capping in the treatment of severe spleen injuries." Medical review 58, no. 7-8 (2005): 388–92. http://dx.doi.org/10.2298/mpns0508388j.

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Introduction Permanent and lifelong threat of developing fatal sepsis and other severe infections in splenectomized patients is an important reason for promoting splenic preservation. Material and methods Experimental preservation of severe spleen injuries (grade IV), with splenic-capping, was performed in 30 dogs, operated using Ketalar anesthesia. Spleen preservation and concomitant treatment of excessive hemorrhage were achieved by highly controlled "conic" compression of injuried spleen parenchyma, additional hemostatic Z-sutures and fibrin tissue adhesion. Results Satisfactory hemostasis

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Ma, Fei, Shujing Sui, Zhiyuan Yang, et al. "Evaluation of Novel Tranexamic Acid/Montmorillonite Intercalation Composite, as a New Type of Hemostatic Material." BioMed Research International 2022 (February 28, 2022): 1–15. http://dx.doi.org/10.1155/2022/3963681.

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Radiation enteritis—clinically manifested as diarrhea, intestinal bleeding, and so on—is frequently caused when the body is exposed to radiation or radiotherapy because the intestine is radiation-sensitive as an abdominal organ. Therefore, strategies to modulate intestinal hemostasis had inspired an important research trend in the process of preventing and treating radiation enteritis. Based on the structural characteristics of montmorillonite (MMT) and the hemostatic drug tranexamic acid (TXA) which was used clinically to treat enteritis, the tranexamic acid-montmorillonite composite material

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Park, Young-Mok, Hyung-Il Seo, Jae-Hoon Kim, Sung Pil Yoon, Haeshin Lee, and Moon Sue Lee. "Clinical application of a new hemostatic material using mussel-inspired catecholamine hemostat: A pilot study." Annals of Hepato-Biliary-Pancreatic Surgery 26, no. 1 (2022): 98–103. http://dx.doi.org/10.14701/ahbps.21-077.

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Liu, Jiaxi, Xiang Zhou, Yin Zhang, et al. "Rapid hemostasis and excellent antibacterial cerium-containing mesoporous bioactive glass/chitosan composite sponge for hemostatic material." Materials Today Chemistry 23 (March 2022): 100735. http://dx.doi.org/10.1016/j.mtchem.2021.100735.

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Khabadze, Z. S., D. A. Nazarova, E. S. Shilyaeva, et al. "Hemostatic agents in periapical surgery: The systematic review." Endodontics Today 19, no. 3 (2021): 184–87. http://dx.doi.org/10.36377/1683-2981-2021-19-3-184-187.

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Several agents have been used to secure hemostasis during periapical surgery. Their efficacy, biological response and side effects differ from each other.Aim. Of this review article is to assess systematically the available scientific evidence about the clinical response after using hemostatic agents during apical surgery.Materials and methods. The study of publications was produced in the electronic databases such as Google Scholar, PubMed during a systematic review of the literature. Included articles contain information about using hemostatic agents during periapical surgery and their adver

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Rostorguev, E. E., N. S. Kuznetsova, S. E. Kavitskiy, et al. "The implication of liquid hemostatic matrices to prevent hemorrhages during stereotactic biopsy of brain tumors." South Russian Journal of Cancer 5, no. 3 (2024): 8–15. http://dx.doi.org/10.37748/2686-9039-2024-5-3-1.

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Purpose of the study. Development of a method for preventing hemorrhages during stereotactic biopsy of a brain tumor using liquid hemostatic matrices on the example of the drug "Floseal®".Patients and methods. The target of the biopsy is the most representative area of tumor tissue according to the data of various modalities of MRI neuroimaging, including contrast-enhanced ones. Out of 133 patients, 60 patients with signs of intraoperative bleeding along the biopsy needle cannula were included in the study group. Further, patients with signs of intraoperative bleeding along the cannula of the

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Cheng, Yu, Qian Yang, Jiyuan Wang, et al. "Optimization Preparation and Evaluation of Chitosan Grafted Norfloxacin as a Hemostatic Sponge." Polymers 15, no. 3 (2023): 672. http://dx.doi.org/10.3390/polym15030672.

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Considering the great harm to the human body caused by severe and massive bleeding, in this study, chitosan-grafted norfloxacin (CTS-NF) composites were prepared with chitosan (CTS) and norfloxacin (NF) as raw materials by a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-mediated coupling method to solve the limitations of slow hemostatic and poor anti-infective effects of current dressings on the market. The effects of the mass ratio of CTS to NF (MCTS/MNF), reaction temperature T and reaction time t on the grafting rate (η%) of the products were investigated through single factor tests. The

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Ruzibayev, R. Yu, P. Yu Ruzmatov, and D. A. Umarov. "Morphological Assessment Of Wounds Healing In The Region Of Anal Canal In Rats On The Background Of Medicamental Hypocoagulation." American Journal of Applied sciences 03, no. 09 (2021): 5–15. http://dx.doi.org/10.37547/tajas/volume03issue09-02.

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Purpose of the study: to conduct a morphological study of experimental material to assess the features of wound healing in the anal sphincter area when using the domestic drug “Heprocel” as a hemostatic agent. Material and methods. The study was carried out in the Department of experimental surgery and the department of pathological anatomy of the Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov. The state of experimental models of wounds with the application of a hemostatic agent in the form of a gel was studied. The experiments we

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Hu, Zhang, Sitong Lu, Yu Cheng, et al. "Investigation of the Effects of Molecular Parameters on the Hemostatic Properties of Chitosan." Molecules 23, no. 12 (2018): 3147. http://dx.doi.org/10.3390/molecules23123147.

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Hemorrhea is one of the major problems in war, trauma care, and surgical operation that threaten the life of the injured and patients. As a novel polymeric hemostatic agent, biodegradable chitosan can stop bleeding through a variety of approaches. In this paper, chitosan with various molecular parameters was prepared from chitin as raw material through deacetylation, oxidative degradation, hydrophilic modification, and salt formation reactions. The influence of different polymer parameters on the hemostatic effects of chitosan was investigated by in vitro coagulation time and dynamic coagulati

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Hwang, Yeokgu, Yoo Jung Park, Dong-Woo Shim, Jin Woo Lee, and Seung Hwan Han. "Clinical Efficacy of a Kaolin-impregnated Dressing for Hemostatic Control in Diabetic Foot Ulcer Patients Receiving Anticoagulant Therapy in an Outpatient Clinic." Foot & Ankle Orthopaedics 2, no. 3 (2017): 2473011417S0002. http://dx.doi.org/10.1177/2473011417s000213.

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Category: Diabetes Introduction/Purpose: Orthopedic physicians encounter many diabetes patients who receive anticoagulant treatment because vascular diseases are the chief causes of death and disability in these patients. In these patients, if surgery or other procedures are required, it is still unclear whether anticoagulation therapy administration should continue. After discontinuation of anticoagulation therapy, the risk of cardiovascular complications is increased, although complications of bleeding after surgery are decreased; this is a dilemma in the treatment of diabetic foot ulcer. Th

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Qin, Xiaolei, Jean Felix Mukerabigwi, Mingzi Ma, et al. "In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities." e-Polymers 21, no. 1 (2021): 606–15. http://dx.doi.org/10.1515/epoly-2021-0062.

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Abstract Uncontrollable bleeding is still the main cause of post-traumatic deaths due to the blood loss. Moreover, infectious complication of wound is also still a challenging problem for wound healing. Nevertheless, the currently available hemostasis drugs or materials cannot stanch bleeding well due to single function, slow in effectiveness, adhere to wounds easily, poor gas permeability, etc. Therefore, it is of a great significance to utilize a biomedical hemostatic material that can stop bleeding quickly, preventing from bacterial infections, and with good biocompatibility properties. Her

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Zhang, Shuxiang, Xiuxue Lei, Yongle Lv, Lei Wang, and Lu-Ning Wang. "Recent advances of chitosan as a hemostatic material: Hemostatic mechanism, material design and prospective application." Carbohydrate Polymers 327 (March 2024): 121673. http://dx.doi.org/10.1016/j.carbpol.2023.121673.

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Darvin, V. V., A. Ya Ilkanich, M. G. Ryzhikov, A. V. Oganian, and A. V. Satinov. "Modern management of acute non-variceal upper gastrointestinal bleeding." Сибирский научный медицинский журнал 41, no. 6 (2021): 4–17. http://dx.doi.org/10.18699/ssmj20210601.

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Acute, non-varicose bleeding from the upper gastrointestinal tract remains a common clinical problem. Bleeding episodes are associated with high mortality and a significant economic burden on the health care system. Despite the continuing improvement in endoscopic treatment, recurrent bleeding and associated mortality are still a pressing issue. In addition to the well-established modalities of endoscopic hemostasis: injection, thermal, mechanical, used both as mono therapy and as part of a combination therapy, the review discusses the use of novel types of endoscopic devices. The results of t

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Li, Xiang, Wenli Han, Gao He та ін. "Hydrogel-Transformable Antioxidant Poly-γ-Glutamic Acid/Polyethyleneimine Hemostatic Powder for Efficient Wound Hemostasis". Gels 10, № 1 (2024): 68. http://dx.doi.org/10.3390/gels10010068.

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Hemostatic powder, which can absorb large amounts of water and tends to produce repeated hydration with tissue, has been clinically proven as an ideal engineering material for treating wounds and tissues. We herein designed a polypeptide-based hemostatic powder. A water-soluble polypeptide, γ-polyglutamic acid (γ-PGA), was mixed with the polyethyleneimine (PEI), N-hydroxysuccinimide, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide. The solution of these polymers was lyophilized to harvest the γ-PGA/PEI powder (PP hemostatic powder). When deposited on a bleeding wound, the PP hemostatic powde

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Perri, Paolo, Federica Curcio, Michele De Luca, Paolo Piro, Sonia Trombino, and Roberta Cassano. "Evaluation of Chitosan-Based Axiostat as Hemostatic Dressing for Endovascular Procedures in Patients with Leriche Syndrome on Anticoagulant Therapy." Pharmaceuticals 18, no. 4 (2025): 584. https://doi.org/10.3390/ph18040584.

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Background/Objectives: The safe completion of a non-invasive procedure is crucial to the success of an endovascular approach. Chitosan, a natural polysaccharide derived from chitin, is an ideal material for the study and application of medical devices in post-operative wound management. Methods: The present work is based on a retrospective study conducted on a sample of patients treated with Axiostat (a sterile, single-use, non-absorbable dressing), composed of 100% chitosan and designed to instantly stop bleeding through a mucus adhesion mechanism for the treatment of conditions such as Leric

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Kosayev, J. V., I. A. Khasanov, N. S. Abushov, and G. T. Taghi-zade. "The state of lipid exchange, hemostasis, inflammatory reaction and potentials for their correction in indirect revascularization in patients with critical ischemia of lower extremities (a correlation statistical analysis)." Laser Medicine 25, no. 1 (2021): 27–35. http://dx.doi.org/10.37895/2071-8004-2021-25-1-27-35.

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Aim: to study the state of lipid metabolism, hemostasis, inflammatory reaction and the potential for their correction after indirect revascularization in patients with distal steno-occlusion of arteries and critical ischemia of lower extremities (critical ILE).Material and methods. Changes in hemostasis and dynamics of its parameters during the complex surgical treatment in 131 patients with critical ILE and distal arterial stenoocclusion were analyzed. To achieve the targeted goals, patients were divided into the following groups: 34 patients had traditional care (control group); 32 patients

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Edwards, J. Vincent, Elena Graves, Nicolette Prevost, et al. "Development of a Nonwoven Hemostatic Dressing Based on Unbleached Cotton: A De Novo Design Approach." Pharmaceutics 12, no. 7 (2020): 609. http://dx.doi.org/10.3390/pharmaceutics12070609.

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Minimally processed greige (unbleached) cotton fibers demonstrate enhanced clotting relative to highly processed United States Pharmacopeia (USP) type 7 bleached cotton gauze. This effect is thought to be due to the material surface polarity. We hypothesized that a textile could be constructed, conserving the hemostasis-accelerating properties of greige cotton, while maintaining structural integrity and improving absorbance. Spun bond nonwovens of varying surface polarity were designed and prepared based on ratios of greige cotton/bleached cotton/polypropylene fibers. A thromboelastographic an

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Wang, Lei, Wenjun Li, and Song Qin. "Three Polymers from the Sea: Unique Structures, Directional Modifications, and Medical Applications." Polymers 13, no. 15 (2021): 2482. http://dx.doi.org/10.3390/polym13152482.

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With the increase of wounds and body damage, the clinical demand for antibacterial, hemostatic, and repairable biomaterials is increasing. Various types of biomedical materials have become research hotspots. Of these, and among materials derived from marine organisms, the research and application of alginate, chitosan, and collagen are the most common. Chitosan is mainly used as a hemostatic material in clinical applications, but due to problems such as the poor mechanical strength of a single component, the general antibacterial ability, and fast degradation speed research into the extraction

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Shkatula, Y. V., Y. O. Badion, and M. V. Novikov. "Efficiency of Different Methods of Temporary External Hemostasis at the Pre-Hospital Stage of Emergency Medical Care." Novosti Khirurgii 28, no. 6 (2020): 688–93. http://dx.doi.org/10.18484/2305-0047.2020.6.688.

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Objective. To estimate the efficiency of different methods of temporary external hemostasis at the pre-hospital stage of emergency medical care, taking into account the localization of injuries. Material and Methods. The cases (n=86) of prehospital emergency medical care for patients with external bleeding were studied. The data on the victims (age, gender), clinical status (type and location of injuries, type of bleeding), the volume of emergency care, the hemostasis methods used to control bleeding, their efficiency, side effects, difficulty of use were collected, and the duration of the pre

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Şener Akçora, Dila, Deniz Mavuş, Michal Miko, and Kağan Gökçe. "Comparison of Hemostatic and Acute Histopathological Effects of Algan Hemostatic Agent in Experimental Liver Lobectomy Model in rats." Journal of Medical and Dental Investigations 5 (December 31, 2024): e240372. https://doi.org/10.5577/jomdi.e240372.

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Aim: Algan Hemostatic Agent (AHA) is a plant-based material effective in hemostasis. The purpose of this study was to compare the hemostatic efficacy and acute histopathological effects of liquid and powder forms of AHA in rat model of experimental liver lobectomy. Methods: Twenty-four male Wistar albino rats, 10-12 weeks old, were randomly divided into three groups (n=8): control (physiologic saline), AHA-liquid, and AHA-powder. Following the resection of the outer one-third of the left hepatic lobe, physiological saline, liquid and powder, was administered to the injured area for twenty seco

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Lipatov, Vyacheslav Aleksandrovich, Sergej Viktorovich Lazarenko, Dmitry Andreevich Severinov, and Anastasia Valeryevna Tarasova. "STUDY OF HISTOLOGICAL FEATURES OF LIVER REACTION USING NEW SAMPLES OF POLYMERIC HEMOSTATIC MATERIALS IN THE EXPERIMENT IN VIVO." Journal of Experimental and Clinical Surgery 13, no. 1 (2020): 34–40. http://dx.doi.org/10.18499/2070-478x-2020-13-1-34-40.

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Abdominal trauma in 26.7-40.8% of cases is accompanied by trauma of parenchymal organs. The condition of the patient with liver injury in 75% of cases is complicated by the development of hemorrhagic shock. In surgery, to achieve local hemostasis, the most promising method is the topical use of application hemostatic agents, while the composition of such funds determines the effectiveness of hemostasis. The aim of the study is to assess the histological characteristics of the liver using new samples of polymeric hemostatic materials in the experiment in vivo. Materials and methods.

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Largis, Jean Kaminski, and Abraham R. Katz. "Experimental evaluation of amylose succinate absorbable hemostat in a canine model." Journal of Biomedical Materials Research 21, S3 (1987): 299–318. http://dx.doi.org/10.1002/j.1097-4636.1987.tb00027.x.

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Using a semiquantitative animal model of standardized injuries to parenchymatous organs resulting in a range of degrees of hemorrhage, we compared freeze‐dried amylose succinate topical hemostat to the most widely used commercially available products. Hemostatic efficacy parameters included bleeding time, blood loss, incidence of rebleeding, and amount of material used. Although no material was consistently superior in all parameters, in general amylose succinate and microcrystalline collagen performed equally well and both were significantly more effective than oxidized regenerated cellulose.

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Ellis-Behnke, Rutledge G., Yu-Xiang Liang, David K. C. Tay, et al. "Nano hemostat solution: immediate hemostasis at the nanoscale." Nanomedicine: Nanotechnology, Biology and Medicine 2, no. 4 (2006): 207–15. http://dx.doi.org/10.1016/j.nano.2006.08.001.

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