Log in

Relevant bibliographies by topics / Heparin / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Heparin.

Dissertations / Theses on the topic 'Heparin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Heparin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Raghuraman, Arjun. "Designing Non-saccharide Heparin/Heparan Sulfate Mimics." Online version available 8/19/2013, 2008. http://hdl.handle.net/10156/2269.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Carelli, Guareide [UNESP]. "Associação de doses baixas de heparina não fracionada e de heparina de baixo peso molecular na prevenção de trombose venosa experimental." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/88962.

Full text

Abstract:

Made available in DSpace on 2014-06-11T19:23:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2003Bitstream added on 2014-06-13T19:09:44Z : No. of bitstreams: 1 carelli_g_me_botfm.pdf: 357124 bytes, checksum: 5673f0ccb2732bdb65892b407c35e19c (MD5)<br>A heparina é um glicosaminoglicano sulfatado, de cadeia longa, que vem sendo largamente utilizada, desde meados do século passado, no tratamento e profilaxia das tromboses arteriais e venosas e cuja utilização permitiu o desenvolvimento das cirurgias cardíaca e vascular. As heparinas de baixo peso molecular (HBPM) são frações ou fragmentos d

APA, Harvard, Vancouver, ISO, and other styles

3

Noti, Christian. "Synthesis of heparin oligosaccharides and the creation of heparin microarrays /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17150.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Albig, Thomas. "Synthese und Untersuchung von Heparin-Prodrugs auf Glyceridbasis /." [S.l.] : [s.n.], 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7990.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Jaime, Rodríguez Juan Carlos. "Unveiling Heparin and Heparan Sulfate Conformations : a Journey into Paramagnetic NMR Analysis." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF016.

Full text

Abstract:

L'héparine (HP) et les héparane sulfates (HS) sont des polysaccharides sulfatés linéaires qui jouent divers rôles biologiques, notamment dans la croissance cellulaire, l'adhésion, la reconnaissance virale et la métastase du cancer. Leur variété moléculaire et leur motif de sulfatation contribuent à leur polyvalence biologique. Par ailleurs, leur flexibilité conformationnelle a été étudiée par des méthodes telles que la cristallographie aux rayons X et la RMN. Malgré des avancées, interpréter ces caractéristiques reste difficile, surtout pour de longs saccharides. Cette thèse propose l'utilisat

APA, Harvard, Vancouver, ISO, and other styles

6

Nazir, Ahmad Mohamad Farha. "The role of heparin and heparin-binding growth factors in pre-eclampsia." Thesis, Middlesex University, 2016. http://eprints.mdx.ac.uk/21321/.

Full text

Abstract:

The aims of this study tested the hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of pre-eclampsia. Placental tissue from a cohort study of 87 women was performed following uncomplicated pregnancy at term, but not in labour (TNL, n=26), preterm labour (PTL, n=17), following labour onset (TL, n=21), first trimester (FNL, n=4) and pre-eclampsia (PE, n=19)

APA, Harvard, Vancouver, ISO, and other styles

7

KRISHNASAMY, CHANDRAVEL. "MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/18.

Full text

Abstract:

Heparin, a glycosaminoglycan (GAG), is a complex biopolymer of varying chain length and consisting of uronic acid and glucosamine residues, which are sulfated at various positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of antithrombin, without which the hep

APA, Harvard, Vancouver, ISO, and other styles

8

Sachchidanand. "Heparin binding to fibronectin." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393457.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Evans, Dyfed Ll. "The heparin activateable serpins." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385390.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Freitas, Cristiane Fonseca. "Efeitos do Bay 41-2272 na hipertensão pulmonar experimental em cães anestesiados." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308951.

Full text

Abstract:

Orientador: Edson Antunes<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T08:05:23Z (GMT). No. of bitstreams: 1 Freitas_CristianeFonseca_D.pdf: 2119434 bytes, checksum: 58a318beb1d3946d852e010325a6187c (MD5) Previous issue date: 2007<br>Resumo: Neste estudo, investigamos os efeitos protetores do BAY 41-2272 sobre a hipertensao pulmonar induzida pelo complexo heparina-protamina e hipoxia em cães anestesiados. Os animais foram anestesiados com pentobarbital sodico (Hypnol, 30mg/kg, iv) combinado com citrato de fen

APA, Harvard, Vancouver, ISO, and other styles

11

Pazzini, Carla. "Preparação e caracterização de nanoparticulas com heparina e sua avaliação em modelo animal de trombose venosa." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310166.

Full text

Abstract:

Orientadores: Joyce Maria Annichino-Bizacchi, Nelci Fenalti Hoher<br>Dissertação (mestrado) - Universidade Estadual de Campinas. Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-15T09:49:31Z (GMT). No. of bitstreams: 1 Pazzini_Carla_M.pdf: 2143259 bytes, checksum: b3ff6eb2527b691a4021526983ef2aeb (MD5) Previous issue date: 2010<br>Resumo: A heparina é um anticoagulante amplamente empregado no tratamento e profilaxia da trombose venosa profunda (TVP). Algumas limitações do seu uso são o custo e a via de administração, endovenosa ou subcutânea, às vezes em doses repetidas e

APA, Harvard, Vancouver, ISO, and other styles

12

Ayerst, Bethanie Imogen. "GDF5 mediated enhancement of chondrocyte phenotype and its modulation by heparin and heparan sulfates." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/gdf5-mediated-enhancement-of-chondrocyte-phenotype-and-its-modulation-by-heparin-and-heparan-sulfates(e835db9b-e63e-4301-8cea-df879b052402).html.

Full text

Abstract:

Articular cartilage plays a vital role in load-bearing joints, providing an almost frictionless surface to articulating bones. However, the avascular nature and low cell density of the tissue means that following injury, there is limited potential for regeneration and repair. With the ageing population, the prevalence and economic burden associated with osteoarthritis (OA) is increasing rapidly, but as of yet there are no fully effective ways to treat the condition. Research into novel therapies has therefore become a popular avenue of investigation, and human mesenchymal stem/stromal cells (h

APA, Harvard, Vancouver, ISO, and other styles

13

Jia, Juan. "Structure and functions of heparan sulfate/heparin - Importance of glucuronyl C5-epimerase and heparanase." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107202.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Teka, Girma. "NaCl, Heparin, and Heparan Sulphate Affects Binding of Rift Valley Fever Virus to Human Cells." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58534.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Bernstein, Howard. "A system for heparin removal." Thesis, Massachusetts Institute of Technology, 1985. http://hdl.handle.net/1721.1/15291.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1985.<br>MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.<br>Bibliography: leaves 255-264.<br>by Howard Bernstein.<br>Ph.D.

APA, Harvard, Vancouver, ISO, and other styles

16

Fitton, Hazel Louise. "Modulation of antithrombin by heparin." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624993.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Bromfield, Stephen M. "Multivalent heparin binding and sensing." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/7943/.

Full text

Abstract:

Heparin therapy involves the clinical use of heparin as an anti-coagulant, for example, during surgery. At the conclusion of treatment, systemic heparin levels must be quantified to allow accurate dosing of a heparin antidote. This thesis details work towards a better sensing methodology and an improved antidote. A synthetically-simple arginine-functionalized dye – Mallard Blue (MalB) – was synthesised and shown able to detect heparin across a clinically relevant concentration range in biological media such as human serum. The heparin binding of MalB is selective over structurally related glyc

APA, Harvard, Vancouver, ISO, and other styles

18

Kropf, Sabine [Verfasser]. "Heparin-induzierte Thrombozytopenie: Inzidenz von Heparinantikörpern bei Patienten nach orthopädischen Operationen und nachfolgender Thromboseprophylaxe mit unfraktioniertem Heparin im Vergleich zu niedermolekularem Heparin / Sabine Kropf." Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1013341236/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Dalton, Charlotte. "Chemical synthesis of heparan sulfate oligosaccharides for use in single molecule fluorescence analysis." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/chemical-synthesis-of-heparan-sulfate-oligosaccharides-for-use-in-single-molecule-fluorescence-analysis(a0780c20-6269-4a5c-95d0-376ffa72b3af).html.

Full text

Abstract:

Heparan sulfate (HS) is a cell-surface sulfated polysaccharide that binds to multiple proteins and has been implicated in cancer, viral infection and Alzheimer's disease. Due to the heterogeneity of HS, the structural requirements for protein binding are ill- defined. Chemical synthesis of structurally-defined HS oligosaccharides, which are tunable in terms of length, order of monosaccharides and sulfation pattern, is required for the investigation of HS-protein binding. Single molecule methods have been utilised in biophysics to study dynamic processes and can allow observation of rare events

APA, Harvard, Vancouver, ISO, and other styles

20

Johnson, Wyatt. "Metalloglycomics: Investigating the Interactions of Metal Complexes with Heparan Mimetics." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5672.

Full text

Abstract:

Proteoglycans containing Heparan Sulfate (HS), a sulfated glycosaminoglycan (GAG), play a major role in the cell signaling process, interacting with many different proteins. HS is over expressed on the surface of many cancer cells. Enzymatic cleavage of HS-GAGs by heparanase causes release of angiogenic growth factors leading to tumor cell migration. Heparanase is also over-expressed in tumors with significant correlation between metastatic potential and heparanase activity. Proteoglycans and their associated enzymes are thus significant drug targets of high biological relevance. A functional

APA, Harvard, Vancouver, ISO, and other styles

21

Brito, Adriana da Silva. "Potencial terap?utico de um heparin?ide isolado do invertebrado marinho Litopenaeus vannamei." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12521.

Full text

Abstract:

Made available in DSpace on 2014-12-17T14:03:25Z (GMT). No. of bitstreams: 1 AdrianaSB.pdf: 1664966 bytes, checksum: 33b28b577c6c69f20823f4e4a84e7540 (MD5) Previous issue date: 2008-06-13<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The occurrence of bioactive compounds in marine organisms comes awaking the interest of the pharmaceutical industry. Heparin, a sulfated polysaccharide which presence was already identified in several marine invertebrates, is very attractive due its remarkable functional versatility. Besides to intervene in blood coagulation, this molecule ha

APA, Harvard, Vancouver, ISO, and other styles

22

Glushka, John. "The synthesis of disaccharides related to heparin /." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72844.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Hasan, Jurjees. "Heparin oligosaccharides inhibit angiogenesis in vivo." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488657.

Full text

Abstract:

The prototypic heparan sulfate (HS)-dependent angiogenic cytokine is FGF-2. Here we present the first in vivo study of size fractionated heparin oligosaccharides in 3 models of angiogenesis that are progressively less dependent on FGF-2. We developed the modified hollow fibre assay, a novel model for quantifying angiogenesis in vivo. We tested the ability of size defined oligosaccharides (dp 6-14) to inhibit FGF-2 in a sponge model of angiogenesis, where the process can be driven by a defined angiogenic molecule. Sponges were implanted subcutaneously and injected with FGF2 100 ng/day and oligo

APA, Harvard, Vancouver, ISO, and other styles

24

Jin, L. "Antithrombin structures and the heparin pentasaccharide." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605606.

Full text

Abstract:

Antithrombin, the major inhibitor of blood coagulation, is relatively inactive until it binds to, and is achieved by the heparan sidechains that line the microvasculature. The binding specifically occurs to a core pentasaccharide, present both in the heparans and in their therapeutic derivative heparin. This specific binding can cause antithrombin's conformational change which is required for activation. The crystal structure of a dimer of inhibitory(I) and latent(I) antithrombin, each in complex with the high-affinity pentasaccharide, was solved at 2.9A resolution. To achieve this, a new appr

APA, Harvard, Vancouver, ISO, and other styles

25

Christey, Peter B. "Heparin binding and activation of antithrombin." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315820.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Spinelli, Frances Josephine. "Characterization of heparin-based hydrogel networks." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 102 p, 2009. http://proquest.umi.com/pqdweb?did=1663116581&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

LUNA, Rayana Leal de Almeida. "Influência de citocinas e fatores de crescimento em modelos murinos de pré- eclampisia de perda gestacional: alvos-terapêuticas alternativos na prevenção do aborto e na má-formação vascular fetal." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17879.

Full text

Abstract:

Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-09-19T13:51:01Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Tese_RayanaLuna_2016 (1).pdf: 8156604 bytes, checksum: 38605ef2e80adea3732612e363d4a7d2 (MD5)<br>Made available in DSpace on 2016-09-19T13:51:02Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Tese_RayanaLuna_2016 (1).pdf: 8156604 bytes, checksum: 38605ef2e80adea3732612e363d4a7d2 (MD5) Previous issue date: 2016-06-15<br>FACEPE<br>O desenvolvimento

APA, Harvard, Vancouver, ISO, and other styles

28

Vecchietti, D. G. "Low Molecular Weight Heparins : in depth structural characterization to understand their different biological properties." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/59669.

Full text

Abstract:

Heparin is a linear, heterogeneous, highly sulfated polysaccharide belonging to the family of glycosaminoglycans, endowed with anticoagulant and antithrombotic properties. Its linear chains are made up of 15-200 disaccharide units of N-sulfated or N-acetylated D-glucosamine linked to hexuronic (glucuronic or iduronic) acid. Low molecular weight heparins (LMWHs), developed to circumvent some unwanted side effect of unfractionated heparins (UFH), are obtained from UFH by diverse chemical and enzymatic depolymerisation processes. Fragments generated by cleavage of heparin may therefore structur

APA, Harvard, Vancouver, ISO, and other styles

29

Matthíasson, Stefán E. "Low molecular weight heparin and dextran in thromboprophylaxis human and experimental studies /." Malmö : Dept. of Surgery, Lund University, Malmö General Hospital, 1994. http://books.google.com/books?id=9OxsAAAAMAAJ.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Gandara, Esteban. "Is an Intermediate Dose of LMWH Effective for Secondary Prevention of Recurrent Venous Thromboembolism in Pregnant Patients Diagnosed with Deep Vein Thrombosis or Pulmonary Embolism? Design of a Pilot Study." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23388.

Full text

Abstract:

Statement of the problem The primary objective of this thesis was to determine the best study design to evaluate the safety and effectiveness of an intermediate dose of low molecular weight heparin for secondary prevention of pregnancy associated VTE (PAVTE). An RCT was deemed unfeasible,so the use of a single arm study with prior evaluation of feasibility with a pilot study is proposed. // Methods - A systematic review was conducted to evaluate the efficacy of current strategies used for secondary prevention of PAVTE.A survey was used to elicit the non-inferiority margin. // Results - The poo

APA, Harvard, Vancouver, ISO, and other styles

31

Raiber, Eun-Ang. "Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction." Thesis, University of Salford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490260.

Full text

Abstract:

Control of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Factors (FGFs). They bind to specific transmembrane tyrosine kinase receptors at the cell surface. This can only take place in the presence of heparin and heparan sulfate proteoglycans. The literature in this area is reviewed.

APA, Harvard, Vancouver, ISO, and other styles

32

Eldridge, Stacie Liane. "Development of analytical methods for trace impurity analysis and structure determination of heparin/heparan sulfate-derived oligosaccharides." Diss., [Riverside, Calif.] : University of California, Riverside, 2009. http://proquest.umi.com/pqdweb?index=0&did=1899476621&SrchMode=2&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1269284173&clientId=48051.

Full text

Abstract:

Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed March 10, 2010). Includes bibliographical references. Also issued in print.

APA, Harvard, Vancouver, ISO, and other styles

33

Powell, Andrew Keith. "Characterisation of the interaction of fibroblast growth factor receptors with heparan sulphate." Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288866.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Douglas, Michael Stephen. "Endothelial inflammation : examination of the role of glycosaminoglycans." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Brack, Michael John. "Heparin and restenosis following angioplasty : a study of the effect of subcutaneous heparin on angiographic recurrence following angioplasty." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34223.

Full text

Abstract:

Restenosis following percutaneous transluminal coronary angioplasty (PTCA) continues to be the major limitation of the procedure with an incidence of 30-50%. The restenotic process is characterised by myointimal hyperplasia, initiated by smooth muscle cell migration and proliferation. Work in animal models of vascular injury suggests that heparin may reduce myointimal hyperplasia and hence restenosis. I therefore evaluated the effects of unfractionated heparin, 12 500 IU, twice daily, for 4 months, on angiographic and clinical restenosis following PTCA. 339 patients were randomised to receive

APA, Harvard, Vancouver, ISO, and other styles

36

Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

Full text

Abstract:

Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because

APA, Harvard, Vancouver, ISO, and other styles

37

Chen, Iris Ye Wu. "The interactions between human antithrombin and heparin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0005/NQ42731.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Brigstock, David Roger. "Heparin-binding growth factors from porcine uterus." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279306.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Lietha, Daniel. "Structure and function of NK1-heparin complexes." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407953.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Kesby, Gregory John. "Heparin and cranial neurulation in the rat." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259732.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Belzar, Klara Jane. "The allosteric activation of antithrombin by heparin." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621213.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Bergmann, Carl W. "Studies on the anticoagulant determinants of heparin /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487268021748443.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Xu, Ruoyan. "Analysis of fibroblast growth factor-heparin interactions." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/8833/.

Full text

Abstract:

The functions of a large number (> 435) of extracellular regulatory proteins are controlled by their interactions with heparan sulfate (HS). In the case of fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF receptor. However, the specificity of the interaction of FGFs with HS is still debated. In this thesis, a panel of FGFs (FGF-1, FGF-2, FGF-7, FGF-9, FGF-18 and FGF-21) spanning five FGF sub-families were used to probe their specificities for HS/heparin at different lev

APA, Harvard, Vancouver, ISO, and other styles

44

Hadfield, Lynsay Claire. "Heparin and heparin-like molecules inhibit the Alzheimer's β-secretase (BACE1) : considerations for biological assay and future therapeutic development". Thesis, Keele University, 2018. http://eprints.keele.ac.uk/4998/.

Full text

Abstract:

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, β-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research groups investigating the activity of heparin with BACE1 have demonstrated both inhibitory and stimulatory effects of this glycosaminoglycan, and other analogues. In an attempt to understand this relationship, a review of the available recombinant BACE1 products was conducted to determine if protein purification tag had an effect on the heparin/heparan s

APA, Harvard, Vancouver, ISO, and other styles

45

Kimmerle, Sabine. "Rapid determination of Anti-Heparin/Platelet factor 4 antibody titers in the diagnosis of Heparin-induced Thrombocytopenia$cSabine Kimmerle." Bern : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

McClarence, David. "An investigation into the location of the heparan sulphate/heparin-binding site of human bone morphogenetic protein-7." Thesis, Royal Holloway, University of London, 2011. http://repository.royalholloway.ac.uk/items/77a3aece-4752-648b-2480-49a0f059ffc2/10/.

Full text

Abstract:

The bone morphogenetic proteins (BMPs) are small cystine-knot-containing cytokines that serve pivotal functions during the development of a wide range of tissues. Consisting of approximately twenty structurally and functionally related proteins, the BMP family makes up the largest branch of the transforming growth factor beta (TGF-β) superfamily. At least three of the BMPs have the ability to bind to heparan sulphate (HS) and heparin, which are highly sulphated, complex polysaccharides that are found in abundance on cell surfaces and in the extracellular matrix. The functional significance of

APA, Harvard, Vancouver, ISO, and other styles

47

Coelho, Luciana de Figueir?do. "Efeito anti-inflamat?rio do heparin?ide isolado do camar?o Litopenaeus vannamei sobre a peritonite aguda." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12611.

Full text

Abstract:

Made available in DSpace on 2014-12-17T14:03:42Z (GMT). No. of bitstreams: 1 LucianaFC_DISSERT.pdf: 1219461 bytes, checksum: 86df41deecc523bb278b7a9bc3b86ec9 (MD5) Previous issue date: 2013-03-04<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>In recent years the heparin has been the subject of several studies that aim to expand its use as a therapeutic agent, due to its ability to modulate the activity of various proteins that play important roles in the regulation of pathophysiological processes. In several experiments and preclinical trials, heparin has demonstrated an a

APA, Harvard, Vancouver, ISO, and other styles

48

Chan, Harriet S. C. "Duration of subcutaneous heparin injections : effect on bruising and pain." Thesis, Curtin University, 2000. http://hdl.handle.net/20.500.11937/460.

Full text

Abstract:

Injection site-pain and bruising are common side effects of subcutaneous heparin injections. These adverse outcomes are problematic for both the patient and the nurse. Specifically, site-pain causes the patient discomfort and bruising limits possible sites for subsequent injections. It is important that nurses use an injection technique that minimises the incidence of adverse outcomes when administering subcutaneous heparin injections. This study examines the effect of duration of subcutaneous heparin injection on site-pain intensity and bruise size experienced by a group of patients being tre

APA, Harvard, Vancouver, ISO, and other styles

49

Witte, Andreas. "Darstellung und Reinigung von Chondroitinsulfat-Tetrasacchariden NMR-Studien zur Bindung von Chondroitinsulfat und Heparin an Proteine /." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=958880050.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Yeung, Man-nga, and 楊文雅. "Functional roles of heparanase in endochondral ossification." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!