Relevant bibliographies by topics / Heparinoid

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Heparinoid'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Heparinoid"

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Успенская, М. С., М. Г. Ляпина, and Е. С. Майстренко. "A heparinoid from peony roots (Paeonia anomala): effects on polymerization and dissolution of fibrin in thrombosis." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 2() (June 8, 2020): 80–84. http://dx.doi.org/10.25557/0031-2991.2020.02.80-84.

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Исследование гепаринов и гепариноидов в качестве антитромботических агентов актуально для физиологии и медицины. Многие растения включают гепариноподобные компоненты (гепариноиды), которые препятствуют тромбообразованию. Цель - установление влияния экстракта из корней пиона «Марьин корень» (Paeonia anomala), содержащего гепариноид, на полимеризацию фибрина при процессах тромбообразования ex vivo и определение возможных механизмов его антитромботического действия. Методика. Исследовано влияние гепариноида из пиона (Paeonia anomala) на процессы растворения фибрина в условиях тромбообразования ex
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Alban, S., and A. Greinacher. "Heparinoide als eine Alternative für die parenterale Antikoagulation bei Patienten mit Heparin-induzierter Thrombozytopenie." Hämostaseologie 16, no. 01 (January 1996): 41–49. http://dx.doi.org/10.1055/s-0038-1656637.

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ZusammenfassungDie Heparin-induzierte Thrombozytopenie (HIT Typ II) ist eine lebensbedrohliche Komplikation der Heparintherapie. Da betroffene Patienten durch diese immunologische, unerwünschte Wirkung der Heparingabe gefährdet sind, neue throm-boembolische Gefäßverschlüsse zu entwickeln, ist bei hinreichendem klinischen Verdacht die sofortige Umstellung auf ein kompatibles Antikoagulans notwendig. Hierfür kommen, neben rekombinantem Hirudin, verschiedene Heparinoide in Betracht. Die Pathophysiologie der HIT Typ II sowie die Struktur und die anti-koagulatorischen Eigenschaften verschiedener He
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Greinacher, A., I. Michels, V. Kiefel, and C. Mueller-Eckhardt. "A Rapid and Sensitive Test for Diagnosing Heparin-Associated Thrombocytopenia." Thrombosis and Haemostasis 66, no. 06 (1991): 734–36. http://dx.doi.org/10.1055/s-0038-1646493.

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SummaryHeparin-associated thrombocytopenia (HAT) is a severe complication of heparin therapy. Its diagnosis is difficult. Conventional assays employ platelet aggregometry (PAA) and/or 14C-serotonin release (SRA) which are either insensitive (PAA) or require radioactive tracers (SRA). We here describe a newly developed sensitive and rapid assay based on visual evaluation of heparin-induced platelet activation (HIPA) in microtiter wells. Using sera of 34 patients with clinically suspected HAT we found the HIPA assay to be as sensitive as the SRA and superior to PAA. The HIPA assay allows investi
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Ishihara, Masayuki, Shingo Nakamura, Yoko Sato, Tomohiro Takayama, Koichi Fukuda, Masanori Fujita, Kaoru Murakami, and Hidetaka Yokoe. "Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers." Molecules 24, no. 24 (December 17, 2019): 4630. http://dx.doi.org/10.3390/molecules24244630.

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Heparinoid is the generic term that is used for heparin, heparan sulfate (HS), and heparin-like molecules of animal or plant origin and synthetic derivatives of sulfated polysaccharides. Various biological activities of heparin/HS are attributed to their specific interaction and regulation with various heparin-binding cytokines, antithrombin (AT), and extracellular matrix (ECM) biomolecules. Specific domains with distinct saccharide sequences in heparin/HS mediate these interactions are mediated and require different highly sulfated saccharide sequences with different combinations of sulfated
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&NA;. "Heparin/heparinoid." Reactions Weekly &NA;, no. 1405 (June 2012): 20–21. http://dx.doi.org/10.2165/00128415-201214050-00070.

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Mimura, Wataru, and Manabu Akazawa. "The Association Between Internet Searches and Moisturizer Prescription in Japan: Retrospective Observational Study." JMIR Public Health and Surveillance 5, no. 4 (October 8, 2019): e13212. http://dx.doi.org/10.2196/13212.

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Background Heparinoid is a medication prescribed in Japan for skin diseases, such as atopic dermatitis and dry skin. Heparinoid prescription has increased with instances of internet blogs recommending its use as a cosmetic. Objective This study aimed to examine the prescription trends in moisturizer use and analyze their association with internet searches. Methods We used a claims database to identify pharmacy claims of heparinoid-only prescriptions in Japan. Additionally, we used Google Trends to obtain internet search data for the period between October 1, 2007, and September 31, 2017. To an
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ARGE, E. "Heparinoid and Heparin." Acta Medica Scandinavica 155, no. 6 (April 24, 2009): 469–74. http://dx.doi.org/10.1111/j.0954-6820.1956.tb14396.x.

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Preissner, K. T. "Heparinoids and cellular interactions in the vascular system." Hämostaseologie 16, no. 01 (January 1996): 28–34. http://dx.doi.org/10.1055/s-0038-1656635.

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SummaryHeparin and related polysaccharides have long been used for therapautic intervention in different disease states related to thromboembolic complications. The localization and functional availability of heparin-like components in the body is mostly confined to cell surfaces and extracellular matrix/basement membranes. Their strategic position particularly in the vascular system enables heparinoids linked to various core proteins (designated as heparan sulfate proteoglycans) to interact with a variety of heparin-binding proteins such as apolipoproteins, lipases, proteases and protease inh
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Muhl, Lars, Etty Zwang, Neta Ilan, Yair Herishanu, Varda Deutsch, Elizabeth Naparstek, Israel Vlodavsky, Klaus Preissner, and Ben-Zion Katz. "Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms." Thrombosis and Haemostasis 98, no. 12 (2007): 1193–99. http://dx.doi.org/10.1160/th07-04-0256.

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SummaryA key element for the physiological restriction of blood coagulation at the endothelial cell surface is its non-thrombogenic property, mainly attributed to cell surface heparan sulfate proteoglycans. Heparanase is an endo-β-D-glucuronidase with specific heparan sulfate degrading activity, which is produced and stored in platelets, and is released upon their activation. We examined the effects of heparanase pro-enzyme on coagulation functions, predominantly under physiological conditions. While heparanase pro-enzyme does not directly affect coagulation protein activities, it has profound
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Du, ZhenXing, XueJing Jia, Jing Chen, SiYi Zhou, JianPing Chen, XiaoFei Liu, XiaoHuang Cao, SaiYi Zhong, and PengZhi Hong. "Isolation and Characterization of a Heparin-Like Compound with Potent Anticoagulant and Fibrinolytic Activity from the Clam Coelomactra antiquata." Marine Drugs 18, no. 1 (December 19, 2019): 6. http://dx.doi.org/10.3390/md18010006.

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Heparin from mollusks with unique sulfated glycosaminoglycan exhibits strong anti-thrombotic activities. This study reports on a purified heparinoid from Coelomactra antiquata, which shows potent anticoagulant and fibrinolytic abilities. Its structure was characterized by infrared spectroscopy, high-performance liquid chromatography, and one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy. Its fibrinolytic activity was determined in vitro and in vivo. Its anticoagulant activity was determined by activated partial thromboplastin time (APTT), prothrombin time (PT), and th
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Dissertations / Theses on the topic "Heparinoid"

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Broberg, Karl Rufus. "Synthetic approaches towards heparinoid related saccharides and derivatives." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/synthetic-approaches-towards-heparinoid-related-saccharides-and-derivatives(6c1366ba-82dc-43b2-9af3-294ebed56639).html.

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Heparin glycosaminoglycans mediate a range of biological events, including anticoagulation as well as a diversity of cell proliferation and differentiation processes. Heparin saccharides have been shown to act as inhibitors against angiogenesis and metastasis of tumour cells. This thesis describes work developing chemistry towards varying length oligosaccharide sequences with potential to offer variable sulfation patterns. The main synthetic components to this work were contribution to developing scalable syntheses of an orthogonally protected L-Iduronic acid unit and a differentially protecte
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Brito, Adriana da Silva. "Potencial terap?utico de um heparin?ide isolado do invertebrado marinho Litopenaeus vannamei." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12521.

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Made available in DSpace on 2014-12-17T14:03:25Z (GMT). No. of bitstreams: 1 AdrianaSB.pdf: 1664966 bytes, checksum: 33b28b577c6c69f20823f4e4a84e7540 (MD5) Previous issue date: 2008-06-13<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The occurrence of bioactive compounds in marine organisms comes awaking the interest of the pharmaceutical industry. Heparin, a sulfated polysaccharide which presence was already identified in several marine invertebrates, is very attractive due its remarkable functional versatility. Besides to intervene in blood coagulation, this molecule ha
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Coelho, Luciana de Figueir?do. "Efeito anti-inflamat?rio do heparin?ide isolado do camar?o Litopenaeus vannamei sobre a peritonite aguda." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12611.

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Made available in DSpace on 2014-12-17T14:03:42Z (GMT). No. of bitstreams: 1 LucianaFC_DISSERT.pdf: 1219461 bytes, checksum: 86df41deecc523bb278b7a9bc3b86ec9 (MD5) Previous issue date: 2013-03-04<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>In recent years the heparin has been the subject of several studies that aim to expand its use as a therapeutic agent, due to its ability to modulate the activity of various proteins that play important roles in the regulation of pathophysiological processes. In several experiments and preclinical trials, heparin has demonstrated an a
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Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

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Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because
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Kibondo, Aimee. "Evaluation of the role of heparinoids as immune modulators of organ perfusion solutions." Thesis, University of Sunderland, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556572.

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Kidney transplantation is the only therapy for patients with end-stage kidney failure. There is a shortage of suitable organs from living donors and heart-beating donors (HBDs) leading to an increased use of marginal organs, including those from non- heart-beating donors (NHBD) to expand the donor pool. However, such kidneys are exposed to periods of warm and cold ischaemia plus reperfusion (IR) injury which can be associated with acute tubular necrosis leading to primary non function (PNF), delayed graft failure (DGF) with an increased risk of acute and chronic allograft rejection. Therefore,
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Lukoševičiūtė, Kristina. "Filtracijos efektyvumo ir progesterono, estradiolio, heparino poveikio bulių spermatozoidų kokybiniams rodikliams, įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050919_152311-37566.

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It is the first time in Lithuania that practical application of semen filtration by Sephadex G-15 for the needs of artificial insemination industry was assessed. The efficacy of semen filtration was assessed applying a battery of sperm quality assays to study bovine spermatozoa quality before and after filtration, as well as after cryopreservation. The estimation of effect of different concentrations of progesterone, oestradiol, heparin separately or in combination, on different functional parameters of bull spermatozoa after thawing was performed. These are the first published studies applyin
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Pranckevičienė, Gabrielė. "Pharmacoepidemiologic assessment of low-molecular-weight heparins utilization in Lithuania and development of pharmacoeconomic model." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_141832-70667.

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In recent years, many countries have struggled with the fact that expenditures on health care are growing much faster than the overall level of wealth. Research objectives: 1) to conduct a meta-analysis of heparins by the means of their efficacy, safety parameters and treatment outcomes; 2) to conduct pharmacoepidemiological assessment of long-term heparins utilization in Lithuania; 3) to develop a pharmacoeconomic cost-minimization model for low-molecular-weight heparins based on reference pricing methodology; 4) to investigate heparins prescribing trends and to evaluate heparins prescription
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Kildonavičiūtė, Gabrielė. "Farmakoepidemiologinė/farmakoekonominė vaistų suvartojimo analizė KMUK 2001-2005 metais." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060704_153514-84940.

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Background and Objectives: To perform the analysis of medicines consumption in HKUM from 2001 to 2005; to analyze more comprehensively the usage of Heparins and Antibiotics. Design and Setting: The data about medicines consumption was taken from the hospital pharmacy database in Hospital of Kaunas University of Medicine. Main Outcome Measures: The consumption of medicines was evaluated from the financial stand-point and by the mean of DDD methodology. Also the Meta-analysis of Heparins was performed. In the end, the usage of Antibiotics was evaluated from the financial and DDD stand-points.
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LELIEVRE, SOPHIE. "Implications des adn topoisomerases dans le mecanisme d'action cytotoxique de la suramine, un medicament antitumoral : developpement et caracterisation de cellules resistantes a cet heparinoide." Paris 6, 1994. http://www.theses.fr/1994PA066625.

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La suramine est un compose polyanionique et polyaromatique, possedant des proprietes heparinoides. Sa puissante activite antitumorale, en particulier sur les cancers prostatiques, a inscite au developpement d'etudes pour mettre en evidence ses mecanismes d'action antitumoraux, ce qui permettrait le developpement de derives plus cibles et moins toxiques pour l'organisme. Il semble que les proprietes heparinoides de ce compose soient a l'origine de son interaction avec des composants aussi bien extracellulaires que cytoplasmiques et nucleaires. Ainsi, les effets de la suramine sur certains facte
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COUZI, JEROME. "Thrombopenies immuno-allergiques graves induites par un heparinoide de synthese : le polysulfate de pentosane, a propos de cinq observations du service de cardiologie de nice." Nice, 1988. http://www.theses.fr/1988NICE6501.

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Book chapters on the topic "Heparinoid"

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Harr, Jeffrey N., Philip F. Stahel, Phillip D. Levy, Antoine Vieillard-Baron, Yang Xue, Muhammad N. Iqbal, Jeffrey Chan, et al. "Heparinoid." In Encyclopedia of Intensive Care Medicine, 1080. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1693.

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Wessel, Hans Peter. "Heparinoid mimetics." In Glycoscience Synthesis of Substrate Analogs and Mimetics, 215–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/bfb0119258.

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Harr, Jeffrey N., Philip F. Stahel, Phillip D. Levy, Antoine Vieillard-Baron, Yang Xue, Muhammad N. Iqbal, Jeffrey Chan, et al. "Heparinoids and Synthetic Heparinoids." In Encyclopedia of Intensive Care Medicine, 1080–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_717.

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Stief, T., and P. Kiefer. "Heparin und Heparinoide." In Springer Reference Medizin, 1088–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1419.

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Stief, T., and P. Kiefer. "Heparin und Heparinoide." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_1419-1.

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Oreste, P., and G. Zoppetti. "Semi-synthetic Heparinoids." In Heparin - A Century of Progress, 403–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23056-1_18.

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Harenberg, J., G. Huhle, and U. Hoffmann. "Pharmakologie der Heparine und Heparinoide." In Hämostaseologie, 684–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-07673-6_95.

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Regelson, William. "Heparin, Heparinoids, Synthetic Polyanions, and Anionic Dyes." In ACS Symposium Series, 367–93. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0467.ch024.

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Linhardt, Robert J., and Duraikkannu Loganathan. "Heparin, Heparinoids and Heparin Oligosaccharides: Structure and Biological Activities." In Biomimetic Polymers, 135–73. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0657-3_8.

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Edward Conrad, H. "Heparinoid/Protein Interactions." In Heparin-Binding Proteins, 183–202. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012186060-8/50007-3.

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Conference papers on the topic "Heparinoid"

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Sternberger, A., S. Haas, K. Breddin, and G. Blümel. "COMPARISON OF VARIOUS AMI DOLYTIC HEPARIN ASSAYS: REPORT OF A COLLABORATIVE STUDY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644169.

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The authors performed a controlled study to compare commercially available amidolytic heparin assays based on anti-Xa or anti-I la systems. All participants (see below) were provided with the same batch of all heparin preparations and reagents including homogenous plasma preparation. In addition plasma was spiked with the various unfractionated (n=2) as well as lmwh- (n=5) and heparinoid preparation (n=l). The four university laboratories analyzed all heparin preparations that are registered or used in clinical trials in FRG (n=8). The two testkit producers analyzed registered heparin preparat
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Chong, B. H., F. Ismail, J. Cade, A. S. Gallus, S. Gordon, and C. N. Chesterman. "HEPARIN-INDUCED THROMBOCYTOPENIA: IN VITRO STUDIES WITH LOW MOLECULAR WEIGHT HEPARINOID, ORG 10172." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643926.

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Heparin-induced thrombocytopenia (HIT), an adverse effect of heparin therapy, may be associated with serious thrombosis resulting in severe disability or death. An IgG heparin-dependent antibody may be demonstrated in HIT by platelet aggregation studies with patient serum/plasma and standard (s) heparin. A recent study showed high cross-reactivity of the antibody with low molecular weight (LMW) heparins as most of the 22 patient sera tested gave a positive reaction with various LMW heparins including CY222, CY216, PK10169 and Kabi 2165 (Messmore HL et al, Blood 64(5), 1984 suppl). However, cro
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Sakuragawa, N., S. Saitoh, and K. Takahashi. "INTERACTION BETWEEN CULTURED ENDOTHELIAL CELLS AND ABNORMAL ANTITHROMBIN III "TOYAMA"." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644366.

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Purpose: Abnormal antithrombin III(AT-III)Toyama showed non-affinity to heparin and heparinoid to show loss of immediate antithrombin activity. On the endothelial cells, there are heparinoids including heparan sulfate. We investigated on the interaction between cultured endothelial cells and abnormal AT-III"Toyama" from the viewpoint of antithrombin activity.Materials and methods: (1) Endothelial cell culture:^125I-labelled normal and abnormal AT-III were placed on the washed endothelial cultured cells in 0.2 ml of RPMI-1640 medium for 15 min at 37°C. The medium was suctioned off and the cell
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Turple, A. G. G., M. N. Levin, J. Hirish, C. J. Carter, R. M. Jay, P. J. Powers, M. Andrew, H. N. Magnani, R. D. Hull, and M. Gent. "A DOUBLE BLIND RANDOMIZED TRIAL OF ORG 10172 LOW MOLECULAR WEIGHT HEPARINOID IN THE PREVENTION OF DEEP VEIN THROMBOSIS IN PATIENTS WITH THROMBOTIC STROKE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643239.

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The optimal method of venous thrombosis prophylaxis in patients with stroke is uncertain. ORG 10172 is a low molecular weight heparinoid consisting principally of heparan and dermatan sulphates. In animal studies, ORG 10172 is as effective as unfractionated heparin in preventing venous thrombosis but produces less bleeding. There have been a limited number of descriptive studies on its use in humans, but to date randomized efficacy trials of ORG 10172 in the prevention of venous thrombosis have not been reported. A double blind randomized trial was carried out to compare ORG 10172 with placebo
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Wester, J., F. W. J. Van Mensvoort, D. G. Meuleman, H. ten Cate, C. P. Henny, and J. W. ten Cate. "EFFECTS OF ORG 10172, A NOVEL LMW HEPARINOID ON PRIMARY HAEMOSTASIS IN RATS AND HUMANS. A MORPHOLOGICAL STUDY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643238.

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Org 10172 is a novel low molecular weight heparinoid isolated from animal mucosa with a higher anti-thrombotic/bleeding risk ratio than standard heparin. The effects of Org 10172 and heparin on primary haemostasis in rats and humans have been studied by light and electron microscopy (LM&amp;EM).In rat ears bleeding wounds were inflicted. The wound areas were excised 5, 15 or 30 min. after bleeding induction, and processed for LM and EM. Org 10172 and heparin have been administered in doses of 300 or 600 anti-Xa U/kg i.v., 5 or 1 min. prior to bleeding induction. Bleeding wounds of drug treated
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Gerhart, T., H. Yett, A. Donovan, M. A. Lee, M. Smith, and E. W. Salzman. "ORGANON 10172 VS. WARFARINTO PREVENT VENOUS THROMBOSIS AFTER HIP FRACTURE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643686.

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Deep venous thrombosis (DVT) remains a serious and frequent complication after fracture of the hip, and even the mostefficacious prophylactic agents, e.g., warfarin, may fail to prevent DVT in up to 2056 of cases. There is evidence that low molecular weight heparin or heparin-like agents may have advantages in antithrombotic prophylaxis with reduced hemorrhagic sideeffects in patients at risk of DVT. We are engaged in a randomized prospective trial comparing the antithrombotic effect ofwarfarin (PT 1.5x control)with that of Organon 10172, a mixture ofsulfated low molecular weight glycosamiogly
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van Dinther, T. G., F. Hol, and D. G. Meuleman. "EFFECT OF VARIOUS HEPARIN(OID)S ON HEPARIN COFACTOR II MEDIATED ANTI-THROMBIN ACTIVITY AND INHIBITION OF THROMBIN GENERATION IN VITRO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644353.

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The effects of various heparin(oid)s, standard heparin VII (SH), dermatan sulphate (DS), a low molecular weight fraction of heparin (UMW-H), FragminR (FRA), Org 10172 = low molecular weight heparinoid, the fraction of Org 10172 with high affinity for AT-III (HA-10172) and the low affinity fraction (LA-10172) respectively were examined on in vitro thrombin generation and inactivation.Thrombin inactivation in the presence of either heparin cofactor II (HC-II) or anti-thrombin III (AT-III) was assessed with two newly developed assays using the purified cofactors, thrombin and chromogenic substrat
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Kısa, Alperen. "Heparinin İndüklediği Trombositopeni: Olgu sunumu." In 4th International Symposium on Innovative Approaches in Health and Sports Sciences. SETSCI, 2019. http://dx.doi.org/10.36287/setsci.4.9.076.

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Messmore, H., B. Griffin, J. Seghatchian, and E. Coyne. "HIGH CONCENTRATIONS OF HEPARIN ARE MORE INHIBITORY TO PLATE- AGGREGATION IN-VITRO THAN ARE LOW MOLECULAR WEIGHT HEPARINS AND HEPARINOIDS AT THE SAME CONCENTRATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644186.

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Abstract:
Other investigators have shown that heparin in the usual therapeutic range (0.1-0.5 units/ml) has an enhancing effect on ADP aggregation and an inhibitory effect on collagen and thrombin induced aggregation. The effects of low molecular weight heparin (LMWH)and heparinoids (dermatan sulfate, heparan sulfate) on platelet aggregation have not been as extensivelystudied. We have utilized citrated platelet rich plasma (3.2%citrate-whole blood 1:9) drawn in plastic and adjusted to a final platelet count of 250,000/ul. A Bio-Data 4 channgl aggregometer was utilized with constantstirring at 37 C. The
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Haglund, O., L. Wibell, and T. Saldeen. "EFFECTS OF PENTOSAN POLYSULPHATE (EXMLRON) ON FIBRINOLYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644864.

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Decreased fibrinolytic capacity is thought to be an important ccnponent in the pathqgenesis of different thrombotic states. There is a need for agents improving the fibrinolytic capacity, especially perorally (p.o.) active drugs. Since long the semi-synthetic heparinoid Pentosan Polysulphate (PPS) has been shown to have a stimulating effect on fibrinlysis when given parenterally. Alsop.o. administered drug has been claimedto improve fibrinolysis. However, the degree of gastrointestinal resorption has not been thoroughly assessed and the mechanism behind the effect of PPS cn fibrinolysis is not
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