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Dissertations / Theses on the topic 'Heparinoid'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Broberg, Karl Rufus. "Synthetic approaches towards heparinoid related saccharides and derivatives." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/synthetic-approaches-towards-heparinoid-related-saccharides-and-derivatives(6c1366ba-82dc-43b2-9af3-294ebed56639).html.

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Heparin glycosaminoglycans mediate a range of biological events, including anticoagulation as well as a diversity of cell proliferation and differentiation processes. Heparin saccharides have been shown to act as inhibitors against angiogenesis and metastasis of tumour cells. This thesis describes work developing chemistry towards varying length oligosaccharide sequences with potential to offer variable sulfation patterns. The main synthetic components to this work were contribution to developing scalable syntheses of an orthogonally protected L-Iduronic acid unit and a differentially protecte

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2

Brito, Adriana da Silva. "Potencial terap?utico de um heparin?ide isolado do invertebrado marinho Litopenaeus vannamei." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12521.

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Made available in DSpace on 2014-12-17T14:03:25Z (GMT). No. of bitstreams: 1 AdrianaSB.pdf: 1664966 bytes, checksum: 33b28b577c6c69f20823f4e4a84e7540 (MD5) Previous issue date: 2008-06-13<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The occurrence of bioactive compounds in marine organisms comes awaking the interest of the pharmaceutical industry. Heparin, a sulfated polysaccharide which presence was already identified in several marine invertebrates, is very attractive due its remarkable functional versatility. Besides to intervene in blood coagulation, this molecule ha

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3

Coelho, Luciana de Figueir?do. "Efeito anti-inflamat?rio do heparin?ide isolado do camar?o Litopenaeus vannamei sobre a peritonite aguda." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12611.

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Made available in DSpace on 2014-12-17T14:03:42Z (GMT). No. of bitstreams: 1 LucianaFC_DISSERT.pdf: 1219461 bytes, checksum: 86df41deecc523bb278b7a9bc3b86ec9 (MD5) Previous issue date: 2013-03-04<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>In recent years the heparin has been the subject of several studies that aim to expand its use as a therapeutic agent, due to its ability to modulate the activity of various proteins that play important roles in the regulation of pathophysiological processes. In several experiments and preclinical trials, heparin has demonstrated an a

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4

Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

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Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because

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5

Kibondo, Aimee. "Evaluation of the role of heparinoids as immune modulators of organ perfusion solutions." Thesis, University of Sunderland, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556572.

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Kidney transplantation is the only therapy for patients with end-stage kidney failure. There is a shortage of suitable organs from living donors and heart-beating donors (HBDs) leading to an increased use of marginal organs, including those from non- heart-beating donors (NHBD) to expand the donor pool. However, such kidneys are exposed to periods of warm and cold ischaemia plus reperfusion (IR) injury which can be associated with acute tubular necrosis leading to primary non function (PNF), delayed graft failure (DGF) with an increased risk of acute and chronic allograft rejection. Therefore,

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6

Lukoševičiūtė, Kristina. "Filtracijos efektyvumo ir progesterono, estradiolio, heparino poveikio bulių spermatozoidų kokybiniams rodikliams, įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050919_152311-37566.

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It is the first time in Lithuania that practical application of semen filtration by Sephadex G-15 for the needs of artificial insemination industry was assessed. The efficacy of semen filtration was assessed applying a battery of sperm quality assays to study bovine spermatozoa quality before and after filtration, as well as after cryopreservation. The estimation of effect of different concentrations of progesterone, oestradiol, heparin separately or in combination, on different functional parameters of bull spermatozoa after thawing was performed. These are the first published studies applyin

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7

Pranckevičienė, Gabrielė. "Pharmacoepidemiologic assessment of low-molecular-weight heparins utilization in Lithuania and development of pharmacoeconomic model." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_141832-70667.

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In recent years, many countries have struggled with the fact that expenditures on health care are growing much faster than the overall level of wealth. Research objectives: 1) to conduct a meta-analysis of heparins by the means of their efficacy, safety parameters and treatment outcomes; 2) to conduct pharmacoepidemiological assessment of long-term heparins utilization in Lithuania; 3) to develop a pharmacoeconomic cost-minimization model for low-molecular-weight heparins based on reference pricing methodology; 4) to investigate heparins prescribing trends and to evaluate heparins prescription

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8

Kildonavičiūtė, Gabrielė. "Farmakoepidemiologinė/farmakoekonominė vaistų suvartojimo analizė KMUK 2001-2005 metais." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060704_153514-84940.

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Background and Objectives: To perform the analysis of medicines consumption in HKUM from 2001 to 2005; to analyze more comprehensively the usage of Heparins and Antibiotics. Design and Setting: The data about medicines consumption was taken from the hospital pharmacy database in Hospital of Kaunas University of Medicine. Main Outcome Measures: The consumption of medicines was evaluated from the financial stand-point and by the mean of DDD methodology. Also the Meta-analysis of Heparins was performed. In the end, the usage of Antibiotics was evaluated from the financial and DDD stand-points.

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9

LELIEVRE, SOPHIE. "Implications des adn topoisomerases dans le mecanisme d'action cytotoxique de la suramine, un medicament antitumoral : developpement et caracterisation de cellules resistantes a cet heparinoide." Paris 6, 1994. http://www.theses.fr/1994PA066625.

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La suramine est un compose polyanionique et polyaromatique, possedant des proprietes heparinoides. Sa puissante activite antitumorale, en particulier sur les cancers prostatiques, a inscite au developpement d'etudes pour mettre en evidence ses mecanismes d'action antitumoraux, ce qui permettrait le developpement de derives plus cibles et moins toxiques pour l'organisme. Il semble que les proprietes heparinoides de ce compose soient a l'origine de son interaction avec des composants aussi bien extracellulaires que cytoplasmiques et nucleaires. Ainsi, les effets de la suramine sur certains facte

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10

COUZI, JEROME. "Thrombopenies immuno-allergiques graves induites par un heparinoide de synthese : le polysulfate de pentosane, a propos de cinq observations du service de cardiologie de nice." Nice, 1988. http://www.theses.fr/1988NICE6501.

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11

Jonquères, Anne. "Etude des cas de thrombopenies heparino-induites a l'hopital de rangueil pendant 90 mois : janvier 83 - juin 90." Toulouse 3, 1991. http://www.theses.fr/1991TOU31012.

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12

Moura, Celton Pereira de. "Avalia??o do potencial anti-inflamat?rio, anticoagulante e hemorr?gico de heparin?ides presentes em "Artemia franciscana"." Universidade Federal do Rio Grande do Norte, 2004. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12549.

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Made available in DSpace on 2014-12-17T14:03:31Z (GMT). No. of bitstreams: 1 CeltonPM.pdf: 997721 bytes, checksum: 8ad0354bfbff2f87d7c01316f84484e6 (MD5) Previous issue date: 2004-11-05<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Heparan sulfate (HS) and Heparin (Hep) glycosaminoglycans (GAGs) are heterogeneous and highly charged polysaccharides. HS is structurally related to Hep but is much less substituted with sulfo groups than heparin and has a more varied structure (or sequence). Because of structural similiarities between these two polymers, they have been des

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13

Lozano, Molero Miguel. "Estudio de heparinas y heparinoide de bajo peso molecular, pentasacárido y heparina no fraccionada en un modelo de trombosis "in vitro". Efecto sobre el depósito de plaquetas y la formación de fibrina." Doctoral thesis, Universitat de Barcelona, 1992. http://hdl.handle.net/10803/2262.

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La heparina es una familia de cadenas de glicosaminoglicanos (GAGs) formados por residuos de glucosamina y ácido urónico, cuya eficacia y seguridad en la profilaxis y tratamiento de las enfermedades trombóticas están bien establecidas.<br/><br/>El descubrimiento de que parecía posible desdoblar el efecto inhibidor del factor Xa de la inhibición de la trombina, con las fracciones de bajo peso molecular de la heparina despertó grandes expectativas y condujo a la introducción en terapéutica de las heparinas y heparinoides de bajo peso molecular. Debido a los distintos procedimientos de obtención

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14

Santos, Vanessa Olinto dos. "Polissacar?deos sulfatados de interesse farmacol?gico no camar?o litopenaeus schimitti." Universidade Federal do Rio Grande do Norte, 2006. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12607.

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Made available in DSpace on 2014-12-17T14:03:41Z (GMT). No. of bitstreams: 1 VanessaOS.pdf: 1126102 bytes, checksum: dba464c890585c6be32a3fd2dc600a81 (MD5) Previous issue date: 2006-06-12<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Sulfated Polysaccharides with unique chemical structures and important biological activities has been found in a diversity of sea invertebrates. For that, to exist a huger interest on the biotechnology field in the research theses sulfated compounds isolated from sea organisms. Despite the privileged brazilian position for these compounds att

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15

Durila, Miroslav. "Využití tromboelastografie (TEG) při hodnocení hemokoagulace u pacientů na jednotce intenzivní péče (JIP)." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-297330.

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Patients in the intensive care unit are in critical condition which is often accompanied by a coagulation disorder. Sepsis as a leading cause of death in critically ill patients may be associated with both hypercoagulable state with microtrombi formation in microcirculation and with increased production of endogenous heparinoids with inhibitory effects on blood clotting. Central venous catheter and arterial catheter are established in patients for hemodynamic monitoring and these are flushed with heparin to prevent their closure. Both inputs are used for blood sampling for laboratory tests suc

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16

Brzek, Vladimír. "Sledovánívýskytu heparinové resistence u populace nemocných před operací srdce v mimotělním oběhu." Doctoral thesis, 2010. http://www.nusl.cz/ntk/nusl-278734.

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Heparin resistance occurs in about 20% of population. In that case, after application of a usual dose of heparin (2-3 mg/kg) ACT will not be sufficiently extended. Aim: To determine the real incidence of heparin resistance in patients scheduled for a cardiac surgical procedure. To determine whether there is an association between preoperative treatment with heparin and the incidence of heparin resistance. Also, to establish whether there is an association between platelet count, patients' age, and heparin resistance. Patients and methods: A total of 624 patients scheduled for on-pump surgery w

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17

Wildberger, Kerstin [Verfasser]. "Evaluierung der Prothrombinase-induzierten Gerinnungszeit zum Monitoring der Antikoagulation mit niedermolekularen Heparinen und Heparinoiden / vorgelegt von Kerstin Wildberger." 2011. http://d-nb.info/1011349345/34.

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