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Dissertations / Theses on the topic 'Hepatic disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Carlisle, K. M. "Hepatic haemodynamics in health and disease." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261289.

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2

Kawser, Choudhury Ali. "Regulation of secretion of #alpha#-2 macroglobulin by hepatic lipocytes in relation to hepatic fibrosis." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240644.

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3

Mackinnon, Kathryn Linsey. "Hepatic inactivation of Leu-enkephalin." Thesis, Liverpool John Moores University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337884.

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4

Menon, David Krishna. "Hepatic '3'1P magnetic resonance spectroscopy in parenchymal liver disease." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243481.

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5

Akie, Thomas E. "Regulation of Metabolism by Hepatic OXPHOS: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/857.

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Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent issue in the modern world, predisposing patients to serious pathology such as cirrhosis and hepatocellular carcinoma. Mitochondrial dysfunction, and in particular, diminished hepatic oxidative phosphorylation (OXPHOS) capacity, have been observed in NAFLD livers, which may participate in NAFLD pathogenesis. To examine the role of OXPHOS in NAFLD, we generated a model of enhanced hepatic OXPHOS using mice with liver-specific transgenic expression of LRPPRC, a protein which activates mitochondrial transcription and augments O

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Akie, Thomas E. "Regulation of Metabolism by Hepatic OXPHOS: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/857.

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Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent issue in the modern world, predisposing patients to serious pathology such as cirrhosis and hepatocellular carcinoma. Mitochondrial dysfunction, and in particular, diminished hepatic oxidative phosphorylation (OXPHOS) capacity, have been observed in NAFLD livers, which may participate in NAFLD pathogenesis. To examine the role of OXPHOS in NAFLD, we generated a model of enhanced hepatic OXPHOS using mice with liver-specific transgenic expression of LRPPRC, a protein which activates mitochondrial transcription and augments O

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7

Johnston, Richard David. "Nutritional modulation of hepatic lipid metabolism in health and disease." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12655/.

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The objective of this thesis was to assess the impact of altering macronutrient intakes on hepatic lipid metabolism. Two separate studies were performed, with liver triglyceride content being the principal outcome of both. In the first study 32 healthy and centrally overweight males were randomised to 2 periods, each of 2 weeks, of either a high fructose or glucose intake in a non-crossover fashion. Isoenergetic status was maintained by providing foodstuffs during the first period, followed by a 6 week washout and then a second period of ad libitum overfeeding. In the second study 55 patients

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8

Ren, Hui. "REGULATION OF HEPATIC GENE EXPRESSION DURING LIVER DEVELOPMENT AND DISEASE." UKnowledge, 2012. http://uknowledge.uky.edu/microbio_etds/6.

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My first project was to investigate the role of Hepatocyte Nuclear Factor 1 (HNF1) and Nuclear Factor I (NFI) on alpha-fetoprotein (AFP) promoter activity during liver development. AFP is highly expressed in the fetal liver, silenced at birth, and remains at very low levels in the adult liver. A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). The -120 region harbors overlapping binding sites for HNF1 and NFI. While it has been shown that the GA substitution increas

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9

Purswani, Sudha. "Characterising hepatic B cell subsets in human chronic liver disease." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7590/.

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B cells have been proven to have a significant role in liver fibrosis. We postulate that enrichment of B cell subsets in hepatic diseases may implicate this population in liver pathogenesis. When comparing total B cells from human immune and non-immune-mediated liver disease explants, we found an enrichment of CD20+ B cells in PBC. Furthermore, phenotypic characterization of 11 B cell subsets in matched liver and blood highlighted an enriched naïve peripheral population, and activated B cell subsets in livers. Newly identified CD19+CD24-CD38- and CD19+CD24-CD38int B cells were also augmented i

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10

Ghadieh, Hilda E. "Impaired Hepatic Insulin Clearance Links Fatty Liver Disease to Atherosclerosis." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1533216686796754.

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11

GOTO, HIDEMI, HISAO HAYASHI, NAOKI MIZUTANI, et al. "Biochemical Staging of the Chronic Hepatic Lesions of Wilson Disease." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/19492.

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12

Baghdadi, Hussam Hussein. "Hepatic injury in metabolic syndrome : the role of selenium in models of hepatic injury and healing." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4235.

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Oxidative stress, lipid peroxidation, and endotoxaemia with cytokine-mediated injury have been implicated as factors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The degree of insulin resistance together with co-existing inadequacies of vital antioxidant defence mechanisms may be important determinants of progression to fibrosis in patients with non-alcoholic steatohepatitis (NASH). Current therapies are targeted at improving insulin sensitivity as well as addressing hepatic repair including anti-inflammatory strategies. Anti-oxidants remedies have also been tested but the

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13

Lake, April D. "Hepatic stress response mechanisms in progressive human nonalcoholic fatty liver disease." Thesis, The University of Arizona, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3590010.

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<p> Nonalcoholic fatty liver disease (NAFLD) has become a worldwide, chronic liver disease of increasing clinical significance. It is closely associated with the rising epidemics of obesity and insulin resistance. Up to 17% of the United States population may progress from the disease stage characterized as simple, benign steatosis to the more severe, inflammatory stage of nonalcoholic steatohepatitis (NASH). This progression occurs through 2<sup>nd</sup> 'hits' of increased oxidative stress and inflammation to a liver that has been sensitized by lipotoxic stress. NASH is also characterized by

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14

Wu, Nan. "Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease." The American Physiological Society, 2009. http://hdl.handle.net/1993/23352.

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Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs. Previous studies have shown that hyperhomocysteinemia is related to fatty liver. However, the underlying mechanism remains speculative. The objective of the present study is to investigate the regulatory mechanism of hepatic inflammatory response and cholesterol metabolism during metabolic disorders. In the present study, hyperhomocysteinemia was induced in Sprague-Dawley rats by feeding a high-methionine diet. The mRNA and protein expression of cyclooxygena

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15

Chen, Jye-Daa. "Theophylline disposition in patients with hepatic disease and congestive heart failure." Scholarly Commons, 1992. https://scholarlycommons.pacific.edu/uop_etds/2239.

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The theophylline clearance was evaluated in patients with liver dysfunction and/or congestive heart failure. One hundred and twenty two patients were categorized into four groups; Group I: Liver dysfunction (n=20), Group II: Congestive heart failure (CHF, n=22), Group III: Both liver dysfunction and CHF (n=12), and Group IV: Control group (n=68). The severity of liver dysfunction and CHF were evaluated using Child-Turcotte- Pugh index (CTP) and a Cardiac Function index, respectively. Theophylline clearance was significantly decreased in Groups I, II, and III when compared to the control group;

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16

Hamlin, Allyson. "Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490698940398626.

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17

Roth, Alexander David. "Modeling Liver Diseases Using Hepatic Cell Microarrays." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544719407531728.

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18

Vidot, Marie Helen. "Nutrition Interventions and Chronic Liver Disease." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21592.

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Background The liver has an integral role in all metabolic processes Hypothesis Identification of nutritional abnormalities in patients with CLD facilitates targeted nutrition intervention to improve patient outcomes Aim To investigate specific nutritional features and interventions in patients with CLD Methods The population was adults with CLD All investigations were approved by the Sydney Local Health District Research Ethics and Governance Office Studies included: Retrospective analysis of subjective global assessment (SGA), obesity, malnutrition and muscle wasting in patients with CLD

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19

Reichenbach, Marinkovic Vedrana. "Hepatic remodeling, serum biomarkers and prevention of fibrosis progression in liver disease." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/107757.

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Hepatic fibrosis is characterized by intense tissue remodeling. In this study, we assessed whether CO3-610, a new identified neoepitope, could be used as a surrogate biomarker of liver fibrosis and portal hypertension in CCl4-induced experimental fibrosis. Serum CO3-610 was measured by ELISA. Liver fibrosis was quantified by Sirius red staining. Serum hyaluronic acid (HA) was measured with a binding-protein assay. Gene expression of collagens I and III, MMP2 and MMP9, and tissue inhibitors of matrix metalloproteinase 1 and 2 was quantified by PCR. Hemodynamic measurements were taken in a subgr

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20

Goto, Hidemi, Naoki Ohmiya, Ryoji Miyahara, et al. "HEPATIC PORTAL VENOUS GAS FOLLOWING COLONOSCOPY IN A PATIENT WITH CROHN’S DISEASE." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/18477.

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21

Clinkenbeard, Erica Leigh. "INSIGHTS INTO HEPATIC ALPHA-FETOPROTEIN GENE REGULATION DURING LIVER DEVELOPMENT AND DISEASE." UKnowledge, 2012. http://uknowledge.uky.edu/microbio_etds/1.

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The liver is an essential organ for cholesterol homeostasis. If this process becomes dysregulated, cardiovascular disease (CVD) develops. Zinc-fingers and homeoboxes 2 (Zhx2) as an important hepatic gene regulator and contributes to CVD. BALB/cJ mice, with mutant Zhx2 allele, have fewer atherosclerotic plaques compared to other strains on a high fat diet. In my dissertation, I focused on the liver phenotype in BALB/cJ mice on a high-fat diet and found increased liver damage compared to wild-type Zhx2 mice. These data indicates that reduced Zhx2 in the liver leads to CVD resistance, but increas

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22

Iredale, John Peter. "Tissue inhibitor of metalloproteinase-1 expression by human hepatic lipocytes and its role in liver disease." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295679.

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23

Taylor-Robinson, Simon David. "Magnetic resonance studies in patients with chronic liver disease and following hepatic transplantation." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243596.

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24

Hopkins, Laurence Joseph. "On hepatic stem cells and their role in chronic liver disease and carcinogenesis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5348/.

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Hepatic stem cells are found in the liver at all stages of development, including adult, and have the potential to give rise to daughter cells of biliary, hepatocytic and pancreatic lineages. Hepatic stem cells contribute significantly to liver regeneration, but may be associated with development of primary liver cancer, and are being investigated as a cellular therapy for liver failure. This thesis describes the development of methods for the immunohistochemical quantification of hepatic stem cell activation, allowing assessment of the association between hepatic stem cell activation in needl

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25

Hamato, Noriyuki. "Phase shift of the hepatic vein flow velocity waveform in chronic liver disease." Kyoto University, 1998. http://hdl.handle.net/2433/182243.

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26

Fisher, Craig. "Non-Alcoholic Fatty Liver Disease Alters the Three Stages of Hepatic Drug Management." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195795.

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In pharmacotherapeutics, the term "correct dosing" is based on the concept that too high a systemic concentration will lead to drug toxicity, while drug levels that are too low may not produce the intended therapeutic effect. Often, the factors determining the ability of a patient to manage a given dose rely on their capacity to efficiently metabolize and eliminate drugs from the body. The liver plays a crucial role in the processing of many clinically relevant drugs via three stages of hepatic drug management. Drugs must first be taken into hepatocytes by uptake transporters. Drugs are th

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27

Xanthakos, Stavra A. "Prevalence and Determinants of Hepatic Steatosis in Young Adult Women." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155258455.

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28

MacFarlane, David Peter. "Factors determining the progression of nonalcoholic fatty liver disease : the role of abnormal fatty acid and glucocorticoid metabolism." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5914.

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Obesity and insulin resistance are associated with a constellation of features including hypertension, dyslipidaemia, type 2 diabetes, and premature cardiovascular disease, collectively termed the metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) represents the hepatic component of this syndrome, incorporating a spectrum of liver disease with increasing morbidity and mortality, from simple steatosis, to non-alcoholic steatohepatitis (or NASH), fibrosis, cirrhosis and ultimately hepatocellular carcinoma. However, factors influencing this progression are incompletely understood. In t

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29

Sengupta, Shomit. "The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57673.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The multi-component kinase mTOR complex 1 (mTORC 1) coordinates nutrient and growth factor inputs with numerous downstream processes including protein translation, autophagy, metabolism and cell growth. We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body postnatal growth similar to reduced caloric intake. We found that while feeding activated mTORC 1 in almost every tissue, there was variability i

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30

Shami, Gerald John. "Probing the Unseen Depths of the Hepatic Microarchitecture via Multimodal Microscopy." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20074.

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Multimodal microscopy combines the advantages and strengths of different imaging modalities in order to holistically characterise the organisation of biological organisms and their comprising constituents under healthy and diseased conditions, down to the spatial resolution required to understand the morphology and function of such structures. Given the profound advantages conferred by such an approach, this work broadly aimed to develop and exploit various multimodal and multi-dimensional imaging modalities in a complimentary, combined and/or correlative manner – namely, three-dimensional sca

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31

Mazzeo, Maria. "The Role of Bone Marrow Derived Cells in a Model of Hepatic Regeneration." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08212007-124014/.

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To examine the relationship between liver injury and the appearance of bone marrow derived hepatic cells we performed sex-mismatched bone marrow transplants in mice, with subsequent liver injury. Co-labeling for a marker of donor bone marrow origin and a marker of liver epithelial phenotype allowed us to identify rare marrow-derived hepatocytes at various time points following liver damage. The number of marrow-derived hepatocytes was low, however, and did not allow us to determine if liver-specific injury upregulated this process from baseline. We conclude that while marrow-derived hepatocyte

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32

Flatland, Bente. "Efficacy of the Bromsulfophthalein (BSP) 30-Minute Retention Test for the Diagnosis of Hepatobiliary Disease in Dogs." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/36869.

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Measuring the amount of bromsulfophthalein (BSP) retained in serum 30 minutes after intravenous injection can be used to evaluate hepatic function. BSP retention of less than 5% 30 minutes after intravenous administration is considered normal in dogs. The BSP retention test fell out of favor due to perceived inaccuracy when compared with bile acid and ammonia testing and a fear of hypersensitivity reactions. BSP was discontinued as a commercially-available drug in 1984. Use of BSP has continued at virginia tech despite the test's reputed disadvantages. The purpose of this study was to eva

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33

Pillay, Johara Nadine. "The Effect of Hyperbilirubinaemia on Hepatic Cholesterol Metabolism in the Gunn Rat." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/382734.

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Cardiovascular Disease (CVD) is one of the world’s leading causes of morbidity and mortality, contributing to approximately 30% of the total deaths in Australia. CVD affects the heart and its associated vasculature and affects people of all ages and socio-economic backgrounds. Hypercholesterolaemia is key risk factor associated with the onset of CVD, particularly through its direct contribution to the development of atherosclerosis. Elevation in circulating cholesterol contributes significantly to the progression of atherosclerotic plaques leading to cardiovascular events such as embolism, myo

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34

Flood, Hannah M. "The Forkhead Box F1 Transcription Factor in Disease and Development." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213082789579.

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35

Jimenez-Canet, Mark. "Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/333487.

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Inter-individual variability in drug response is a significant clinical concern and may lead to the development of adverse drug reactions, which are currently a top-ten cause of death in the United States. Recently, the manifestation of disease, which may alter normal physiological function, has gained increased attention for its role as a contributing factor in the development of inter-individual responses to drugs. One such disease, known as nonalcoholic fatty liver disease (NAFLD), is the most common chronic liver disease in Western society and represents a spectrum of clinical morbidities

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36

Tang, Zhi. "Mass spectrometry-based metabolomics to unravel alterations in hepatic cell lines and transgenic mouse model of Alzheimer's disease." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/269.

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Chapter 5 reported the study to assess whether the urinary metabolic alterations linked to early pathophysiological changes in the TgCRND8 mouse model of AD. An unbiased metabolomics approach using high resolution Orbitrap mass spectrometry coupled with hydrophilic interaction liquid chromatography was conducted to uncover the metabolic alterations as a relevant readout of biochemical activity that implicated in the pathogenesis and progression of AD in the TgCRND8 mice. A total of 73 differential metabolites of urine sample sets was identified in 12-week and 18-week transgenic mice compared t

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37

Nishio, Takahiro. "Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis". Kyoto University, 2017. http://hdl.handle.net/2433/225984.

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38

Ditzel, Eric Joseph. "Exposure To Arsenite During Fetal Development Increases Susceptibility To Fatty Liver Disease And Alters Hepatic Transport." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/593627.

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Arsenic is common metalloid that is found globally. Its ubiquitous nature means that large portions of the global population are exposed through a variety of pathways. Arsenic is a known human carcinogen and its role in the development of cardiovascular and metabolic disease has become more completely characterized in the past decades. However, the examination of arsenic exposure during embryonic development at relatively low level exposures is an emergent area where lots of questions remain unanswered. As arsenic is difficult and costly to remove from water, the investigation of exposures in

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39

Chatterjee, Cynthia. "Purinergic Signaling and Autophagy Regulate the Secretion of High-Density Lipoprotein and Hepatic Lipase." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24027.

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Dyslipidemia can be a comorbidity of both insulin-resistance and atherosclerosis. Hypertriglyceridemia is common in hyperglycemia and is associated with hypoalphalipoproteinemia (low HDL) and with altered nucleotide or purinergic signaling. We therefore hypothesized that extracellular nucleotides may affect hepatic lipoprotein metabolism. Our studies confirm this view and show that nucleotides regulate cellular proteolytic pathways in liver cells and thereby control lipoprotein secretion and their metabolism by hepatic lipase (HL). Treatment of liver cells with the nucleotide, adenosine di

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40

Mulder, Jaap. "Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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41

Boon, Ai Ching. "Physiological Effects of Bilirubin: Protection from Protein Oxidation, Kidney Dysfunction and Regulation of Hepatic Lipid Metabolism." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/367250.

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Clinical evidence indicates that hyperbilirubinaemic individuals with Gilbert’s syndrome (GS) are at reduced risk of developing cardiovascular and chronic kidney disease. This thesis consists of five manuscripts which review and explore various mechanisms whereby unconjugated bilirubin (UCB) may prevent cardiovascular disease (CVD) and chronic kidney disease (CKD). The first study of this thesis followed and extended upon the candidate’s Master of Medical Research program. Forty-four age, gender and body mass index matched Gilbert’s syndrome (GS) and healthy controls were recruited and blood w

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42

Santos, José Diogo Macieira de Menezes Pereira dos. "Relação entre a doença periodontal e doenças sistémicas bacterianas no cão : um estudo retrospetivo." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/15825.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A doença periodontal (DP) é uma doença inflamatória causada pela formação de placa bacteriana que afeta o periodonto, a estrutura que suporta os dentes, e que inclui a gengiva, o osso alveolar, o ligamento periodontal e o cemento. A DP é uma das doenças mais frequentemente diagnosticadas tanto em humanos como na prática de clínica veterinária de animais de companhia. Em cães, no entanto, esta doença tende a ser subestimada e por vezes não tratada, ou tratada tardiamente. Têm sido descritos efeitos sistémicos resultantes da DP nos a

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Ruth, Nicola Dawn. "Capturing T-cell receptors : a potential new modality for targeting hepatic tumours and post-transplantational lymphoproliferative disease (PLTD)." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8533/.

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This project sought to identify paediatric tumour-specific phosphopeptide antigens on Post-transplantation lymphoproliferative disease samples (PTLD) and hepatic tumour samples. Tumour-specific T-cells are difficult to maintain in long-term culture, therefore the secondary aim of this project was exploring modalities for capturing T-cell receptor (TCR), important in recognising tumour-specific antigens. This may result in a tumour-specific product. Potential modalities included T-cell hybridomas and Human Induced Pluripotent Stem Cell (hIPSc) technology to immortalise tumour specific T-cells.

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Dookeran, Keith A. "The value of regional intra-arterial therapy with novel sustained-release ethiodol based preparations for hepatic-neoplastic disease." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29858.

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We continue to search for effective therapies for hepatic-metastatic disease. Loco-regional therapy is attractive because it allows for tumour directed dose intensification without associated increase in systemic toxicity, which may lead to improved efficacy. In addition, the use of sustained-release or depot preparations may obviate the need for continuous infusion via expensive implantable pumps, and may also allow treatment of patients who are unfit for surgery, or who have more advanced disease. The iodinated poppyseed oil, Ethiodol, is selectively retained in liver tumours for weeks to mo

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45

Creasy, Kate Townsend. "ZHX2 REGULATION OF LIPID METABOLISM AND THE BALANCE BETWEEN CARDIOVASCULAR AND HEPATIC HEALTH." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacol_etds/10.

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The growing obesity epidemic in America carries with it numerous health risks, including diabetes, increased serum lipid levels, and excess fat accumulation in the liver. If these conditions persist or become exacerbated, they may lead to the development of cardiovascular disease, the current leading cause of death among Americans, or to nonalcoholic fatty liver disease (NAFLD) which can progress to hepatocellular carcinoma (HCC), one of the deadliest forms of cancer. Better understanding of the genes involved in these diseases can lead to improved identification of at-risk individuals and tre

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46

Schneider, Ana Cláudia Reis. "Alterações hepáticas causadas pelo etanol e efeito do tratamento com Lactobacillus rhamnosus GG em zebrafish (Danio rerio)." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/132159.

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Introdução: Em relação ao fígado, a esteatose é a consequência mais comum do consumo abusivo do etanol e predispõe à doença hepática mais grave. Os mecanismos da doença hepática alcoólica não são plenamente conhecidos e as terapias são escassas. Os objetivos desta tese foram: 1) averiguar os efeitos do etanol no fígado, utilizando o zebrafish como modelo experimental; 2) avaliar o tratamento com o Lactobacillus rhamnosus GG (LGG) na esteatose hepática; 3) observar os efeitos do etanol e do tratamento com o LGG no comportamento do zebrafish. Métodos: Foram realizados três experimentos utilizand

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47

Kriss, Crystina Leah. "Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7185.

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Alcohol liver disease (ALD) is a major health concern throughout the world. Currently, in the United States, 17 million people suffer from alcoholism, of which 1.4 million people are receiving treatment [1, 2]. The link between ethanol metabolism, reactive oxygen species (ROS) and liver injury in ALD has been well characterized over the last couple decades [3-10]. Ethanol metabolism relies on the availability of the cofactor NAD+ for the oxidation of ethanol into acetate, consequently causing alterations in redox potential. Redox dysfunction within the mitochondria can affect multiple path

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48

He, Hongbin. "Studies on the genetic control of infection and hepatic disease in schistosoma haematobium and schistosoma japonicum infections in human." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20720.

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La bilharziose reste un problème de santé majeur. L'équipe du Pr Dessein a montré que les infections élevées étaient déterminées par un locus majeur en 5q31 et que des polymorphismes dans un gène à ce locus,IL13, aggravent l'infection. Notre premier objectif était d'évaluer si des variants d'autres gènes de la voie de l'IL13 intervenaient dans le contrôle de l'infection. Nous avons observé une association entre le SNP rs324013, dans le promoteur de STAT6,et les niveaux d'infection à S. haematobium. Ce polymorphisme a un effet additif avec le polymorphisme IL13rs1800925. Ce SN modifie la fixati

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Deng, Difei. "The Association between Gestational Diabetes and Non-alcoholic Fatty Liver Disease: Detection of Hepatic Steatosis and Fibrosis via FibroScan." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24074.

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Background: Non-alcoholic fatty liver disease (NAFLD) and gestational diabetes (GDM) are closely associated in pregnancy. Aim: To explore the antenatal relationships between FibroScan-detected NAFLD and GDM in a multiethnic population of pregnant women Methods: Pregnant women with GDM were recruited for a single FibroScan to determine cross-sectional prevalence of NAFLD. Furthermore, pregnant women without GDM but with risk factors for developing GDM were recruited in early pregnancy (<24/40 weeks gestation) for two sequential FibroScan assessment in early (<24/40 weeks) and late (>30/40 wee

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Karlas, Thomas, and Johannes Wiegand. "Non-Invasive Assessment of Hepatic Steatosis in Patients with NAFLD Using Controlled Attenuation Parameter and 1H-MR Spectroscopy." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-142654.

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Introduction: Non-invasive assessment of steatosis and fibrosis is of growing relevance in non-alcoholic fatty liver disease (NAFLD). 1H-Magnetic resonance spectroscopy (1H-MRS) and the ultrasound-based controlled attenuation parameter (CAP) correlate with biopsy proven steatosis, but have not been correlated with each other so far. We therefore performed a headto- head comparison between both methods. Methods: Fifty patients with biopsy-proven NAFLD and 15 healthy volunteers were evaluated with 1H-MRS and transient elastography (TE) including CAP. Steatosis was defined according to the percen

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