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Dissertations / Theses on the topic 'Hepatic Toxicity and CCl4'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Wild, Stacie Lynn. "Pyrrolizidine alkaloids: Hepatic metabolism and extrahepatic toxicity." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186599.

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Pyrrolizidine alkaloids are proposed to be metabolized in the liver to reactive pyrrole species, or dehydroalkaloids. These reactive pyrroles are hypothesized to be responsible for pyrrolizidine alkaloid toxicity. This dissertation research has established that dehydroalkaloids are, in fact, metabolites of pyrrolizidine alkaloids. It was first determined that dehydromonocrotaline is produced during hepatic microsomal metabolism of monocrotaline and that it has the ability to bind in vitro with a synthetic thiol-containing resin, Thiopropyl Sepharose 6B. Similarly, synthetic dehydromonocrotalin

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2

Powell, Christine Louise Rusyn Ivan. "Improving linkage of hepatic toxicity and pathology endpoints with toxicogenomics." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,997.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine.

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3

Weyers, Carli. "Evaluating metabolism-induced toxicity using a non-hepatic cell line." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/61950.

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4

Sauer, John-Michael. "All- trans-retinol modulation of chemically-induced pulmonary and hepatic toxicity." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187501.

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It has been previously reported that acute hypervitaminosis A in rats dramatically increases the hepatotoxicity of a number of chemicals. This potentiation appears to be mediated by the enhanced release of reactive oxygen species from retinol-primed Kupffer cells. However, in the lung it has been shown that retinol can protect against many of the inflammatory effects caused by bleomycin. Whether or not retinol pretreatment can modulate chemical-induced injury of compounds that cause both liver and lung toxicity is unknown. Therefore, the studies presented here were designed to test the hypothe

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5

Scott, Maya Millicent. "Canine hepatic slices as a model for studying drug toxicity and metabolism." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/3731.

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Tissue slices can be made from organs, such as liver, kidney, brain, and heart, and from various species including humans, dogs, non-human primates, rats and mice. It has been demonstrated that human and rat liver slices are viable for up to 2 days, and liver slices have been extensively used as an in vitro method to study hepatic drug metabolism and toxicity in humans. The objective of this study was to determine the utility of canine hepatic slices as an in vitro model for studying drug metabolism and hepatotoxicity in dogs. Canine hepatic slices were incubated in media containing various dr

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6

de, Barros Pereira I. M. "Investigation of biomarkers of hepatic and renal toxicity in the Han Wistar rat." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1435551/.

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The aim of this project was to identify urinary markers of hepatic and renal toxicity in the male Hanover-Wistar rat; acute and chronic injury models were developed by administration of CCl4. Nephrotoxicity was induced by administration of HCBD. In an acute dose study, CCl4-induced nephrotoxicity occurred above 2.0 mL/kg CCl4. To avoid kidney injury, 2.0 mL/kg CCl4 was chosen as the optimal dose. 1H NMR revealed many changes to the urinary metabolome following CCl4-induced liver injury including an increase in the resonances of taurine, creatine and formate and a decrease in hippurate and crea

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7

Celliere, Géraldine. "Multi-scale modeling of hepatic drug toxicity and its consequences on ammonia detoxification." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC100.

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La détoxification de l'ammoniaque est une fonction clé du foie. Récemment, il a été montré que les réactions communément admises dans ce processus étaient insuffisantes pour comprendre toutes les données expérimentales. Nous avons donc développé des explications possibles sous forme de modèles compartimentaux. Grâce à des procédures statistiques, les modèles ont été évalués et comparés. Il est apparu que l'enzyme glutamate déshydrogénase a une importance capitale dans la détoxification de l'ammoniaque. Lorsque l'on modélise des tissues, le choix de la représentation de l'espace peut influencer

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8

Mesić, Ana. "Space of Disse on Chip Model for Study of Hepatic Toxicity and Inflammation." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPAST044.

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Cette thèse de doctorat s'inscrit dans le cadre du projet ANR DILI on Chip, qui vise à développer un modèle hépatique in vitro sur une puce microfluidique afin d'étudier les lésions hépatiques induites par les médica-ments (Drug-Induced Liver Injury, DILI).Le développement actuel des médicaments repose sur des modèles obsolètes, tels que les cultures cellulaires 2D et les tests in vivo, qui sont coûteux, inefficaces et incapables de prédire avec précision la toxicité hépa-tique. La technologie des organes-sur-puce basée sur la microfluidique constitue une alternative plus précise et dynamique,

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9

Geenen, Suzanne Aleida Birgitta. "Systems biology approach to understanding hepatic glutathione metabolism and its biomarkers of depletion." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/systems-biology-approach-to-understanding-hepatic-glutathione-metabolism-and-its-biomarkers-of-depletion(760cb481-d46b-494b-8aba-e8759aec025a).html.

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Drug induced liver injury is a leading cause of human illness and a major cause of drug withdrawals from the market. A systems biology approach has the potential to aid toxicology research since toxicological responses are a consequence of multiple non-linear and interdependent biological responses. Here such an approach is developed.The glutathione pathway is a key hepatic defence mechanism and deactivates reactive metabolites before they have the chance to damage cellular proteins. However, glutathione availability is limited and can vary between individuals. As hepatic glutathione levels ca

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10

Cardoso, Elsa Maria Pereira. "Lymphocytes in the liver and hepatic iron toxicity : human and animal models of iron overload." Doctoral thesis, Porto : Edição do Autor, 2000. http://hdl.handle.net/10216/64561.

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Cardoso, Elsa Maria Pereira. "Lymphocytes in the liver and hepatic iron toxicity : human and animal models of iron overload." Tese, Porto : Edição do Autor, 2000. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000087509.

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12

Egloff, Caroline. "Effects of Four New Brominated Flame Retardants on Hepatic Messenger RNA Expression, In Vitro Toxicity and In Ovo Toxicity in the Domestic Chicken (Gallus gallus)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19969.

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Brominated flame retardants (BFR) such as hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO), bis(2-ethylhexyl)tetrabromophthalate (BEHTBP), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and decabromodiphenylethane (DBDPE) are contaminants of environmental concern. These BFRs are replacement alternatives for some of the major production BFRs, which have been restricted from the marketplace due to their adverse health effects. Their presence in environmental matrices, including wild birds, suggests they should be tested for possible toxic effects. BFR alternatives have been detected in the

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13

Benlashehr, Imad. "Fumonisin toxicity in ducks and turkeys." Thesis, Toulouse, INPT, 2013. http://www.theses.fr/2013INPT0070/document.

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Les fumonisines (FBs) sont les principales mycotoxines produites par Fusarium verticillioides et Fusarium proliferatum, qui se retrouvent partout dans le monde dans le maïs et ses produits dérivés. Les doses toxiques et les signes cliniques de toxicité provoqués par les FBs varient dune espèce à lautre. La toxicité des FBs est généralement liée à leur capacité à bloquer le métabolisme des sphingolipides chez les espèces animales, y compris chez les espèces aviaires. De précédentes études ont démontré que les canards présentent une plus grande sensibilité à la toxicité des FBs que les dindes, a

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14

O'Brien, Jason. "The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19924.

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Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were perfor

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Lai, Ian Kwan-Tai. "Using dietary strategies to explore mechanisms of hepatic toxicity caused by 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in an animal model." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1157.

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This doctoral dissertation work strived to contribute to the ever expanding knowledge about the mechanisms of polychlorinated biphenyl (PCB) toxicity using dietary strategies. PCBs are a family of persistent environmental pollutants with a wide range of toxicity. The toxicity of PCBs is largely dependent on the congener's chlorination pattern. Of particular interest to this work was 3,3',4,4',5-pentachlorobiphenyl (PCB 126), the most potent of the dioxin-like PCB congeners. I hypothesized that in vivo PCB 126 toxicity will be ameliorated by dietary selenium supplementation, lowered dietary cop

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Boulais, Lilandra. "Cryogel-integrated hepatic cell culture microchips for liver tissue engineering." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2561.

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L’un des enjeux de l’industrie pharmaceutique aujourd’hui est de développer des modèles de foie in vitro fidèles pour améliorer la prédictivité des études précliniques, notamment l’étude de la toxicité et de l’efficacité des médicaments candidats. Ces dernières années, l’ingénierie tissulaire, approche multidisciplinaire pour développer des tissus, a mené au développement de nouvelles méthodes de culture cellulaire. Parmi elles, les cultures de cellules en 3D ou en perfusion ont permis d’obtenir des activités hépatiques similaires à celles observées in vivo. L’objectif de cette thèse est de co

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17

Wartha, Elma Regina Silva de Andrade. "Propriedades antioxidantes de clones do pedúnculo de Anacardium occidentale L.: feito sobre a lipoperoxidação e enzimas participantes do sistema antioxidante de defesa do organismo animal." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-08062017-112859/.

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Os compostos fenólicos são substâncias amplamente distribuídas no reino vegetal, em particular nas frutas e em outros vegetais. Estes compostos, destacando-se flavonoides e os ácidos fenólicos, devido à estrutura molecular, podem apresentar a capacidade de inibir processos oxidativos. Além do mais, estão relacionados com a redução de risco de doenças crônicas não transmissíveis tais como: cardiovasculares, câncer, aterosclerose, entre outras. Considerando a elevada produção de caju em território brasileiro e a possibilidade da existência de compostos com potencial antioxidante no pedúnculo de

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18

Messelmani, Taha. "Development and characterisation of a biomimetic liver on chip featuring 3D hepatic coculture with an endothelial barrier." Electronic Thesis or Diss., Compiègne, 2023. http://www.theses.fr/2023COMP2736.

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Au cours des programmes de développement de médicaments, des modèles animaux sont utilisés pour évaluer le métabolisme et la toxicité des médicaments. Plusieurs cadres juridiques sont établis pour le remplacement, la réduction et l'amélioration de ces expériences. Le foie est un organe central pour la détoxification des molécules exogènes. Par conséquent, le développement de modèles reproduisant les fonctions du foie reste un objectif ambitieux. Ces dernières années, l'association entre l'ingénierie tissulaire et la technologie des organes sur puce a conduit au développement de modèles alterna

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Campos, Neto Armindo de Arruda. "Níveis de exposição a vapores orgânicos e consequências psicofísicas, neurocognitivas e fisiológicas em uma amostra de frentistas brasileiros." Universidade Federal da Paraíba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6955.

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Made available in DSpace on 2015-05-14T13:16:23Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3324327 bytes, checksum: b85304a7fe276b9b7697e2cdf5a23471 (MD5) Previous issue date: 2013-12-06<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>This study aimed at verifying exposure levels for gasoline and ethanol vapors and their psychophysical, neurocognitive, and physiological consequences in a sample of Brazilian pump attendants. Gas chromatography and microclimate sensing were used to passive and active monitoring of environmental levels of vapors. The psychophysic

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20

Marcelino, Renato Ivan de Ávila. "Estudo da atividade quimioprotetora in vitro e in vivo da Eugenia dysenterica dc. (Myrtaceae) após exposição ao cromo hexavalente." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3679.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T12:08:05Z No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T14:01:41Z (GMT) No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a77147

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Alvergnas-Vieille, Magalie. "Effets du bézafibrate sur l'expression et la régulation des enzymes du métabolisme des xénobiotiques et sur le protéome hépatique dans les cultures primaires d'hépatocytes de rat et d'Homme. Impact de l'environnement redox." Thesis, Besançon, 2011. http://www.theses.fr/2011BESA3004.

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Le foie est le principal organe impliqué dans la biotransformation des xénobiotiques. Les cytochromes P450 (CYP) en sont des enzymes dés. Parmi elles, leCYP4A est impliqué dans rhydroxylatlon des acides gras et la biotransformation de médicaments, tels que le bézafibrate (BE2A), un hypolipémiant utilisé enthérapeutique humaine. Cette molécule a été montrée hépatocarcinogène chez les rongeurs mais cet effet n'a pas été rapporté chez l'Homme. H est doncimportant de connaître les mécanismes d'action impliqués dans les effets du BEZA chez l'Homme. Dans une première étude, nous avons étudié l'expre

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22

Lee, Shu-Ping, and 李蜀平. "Evaluation of hepatic protection of tocotrienol rich fraction against CCl4-induced chronic liver injury in rats." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/23894573446934872412.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>97<br>Studies have shown that tocotrienols possess antioxidant, anti-lipid peroxidation, cholesterol lowering, reducing blood coagulating factor thromboxane B2 and anti-cancer activities. In this study, we examined the hepatoprotective effects of palm tocotrienol rich fraction (TRF) against carbon tetrachloride (CCl4) induced chronic liver damage in rats. Study was divided into five groups, namely groups one and two received normal saline without and with CCl4 respectively. Groups three, four and five received silymarin, TRF 25mg/kg (TRF-25), and TRF 50mg/kg (TRF

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Yen, Chih-Tai, and 顏志泰. "Evaluation of hepatic protection of Agaricus blazei-based herbal extract against CCl4-induced oxidative liver injury." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/37054412736796885373.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>95<br>Mushrooms have been used as an important source of nutrition and/or therapy throughout the world since ancient times. Agaricus blazei polysaccharides has been reported to induced with immunomodulatory and antitumor activities. This study was designed to evaluate the effects of Agaricus blazei-based herbal extract on CCl4-induced chronic hepatotoxicity in rats. Male Wistar rats (210 ±10 g) were divided into six groups in this study, including normal control (not treated with CCl4) and groups treated with CCl4, i.e. negative control (only treated with CCl4), posi

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Lee, Yu-Chun, and 李侑純. "Evaluation of hepatic protection of ginseng-based chicken essence against CCl4-induced liver oxidative injury of rat." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93700808787690664499.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>98<br>According to the statistics data of Department of Health Executive Yuan of Taiwan, chronic liver disease and cirrhosis is the seventh leading cause of death in Taiwan in 2008. Preventing and treating liver disease is a public health problem in Taiwan. The aim of this study was to evaluate the hepatoprotective effect of ginseng-based chicken essence (GCE) on carbon tetrachloride (CCl4)-induced acute and chronic liver injuries in rats. In acute experiment, male Wistar rats were randomly divided into six groups: control, CCl4, CCl4 + 0.5 g Silymarin/kg bw/day, CCl

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Tzeng, Cheng-Wei, and 曾承煒. "Solid fermented Antrodia cinnamomea inhibit acute and chronic hepatic injury induced by carbon tetrachloride (CCl4) and quality assessment." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/94202848024195368065.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Antrodia cinnamomea, an endemic fungus in Taiwan, is well-known as a folk medicine, it grows only on the inner heartwood wall of the endemic evergreen Cinnamonum kanehirai and can not be cultivated. It has much physiological activities, including antioxidant, anticancer and hepatoprotective activity, and has active constituents that have anti-hepatitis B virus activity. The purpose of this research is to evaluate the hepatic protective effect of solid fermented A. cinnamomea against carbon tetrachloride (CCl4)-induced acute and chronic hepatic injury in vivo. I

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Hung, Ming-yu, and 洪銘育. "Hepatic protection and antioxidant aciton of water extracts of Du-Zhong (Eucommia ulmoides Oliv.) leaves and Cassia tora L. against CCl4-induced hepatic damage in Rats." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/36319771253068927650.

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碩士<br>國立中興大學<br>食品科學系<br>92<br>Abstract The aim of this study was to investigate the hepatic protection and antioxidation of water extract from Du-Zhong (Eucommia ulmoides Oliv.) leaves (WEDZ) (including its active compounds: chlorogenic acid and protocatechuic acid) and water extract of Cassia tora L. (WECT) against carbon tetrachloride (CCl4) induced hepatic damage in rats. The oral treatment with WEDZ (0.1, 0.5 and 1.0 g/kg rat) for 28 consecutive days and the administration of CCl4 (0.5 mL/rat, 20%) induced hepatic damage in rats. It could find that CCl4 decreas

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Rebelo, Sofia Raquel Paulo. "Development of 3D in vitro models for prediction of hepatic metabolism and toxicity." Doctoral thesis, 2015. http://hdl.handle.net/10362/15268.

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The development of human cell models that recapitulate hepatic functionality allows the study of metabolic pathways involved in toxicity and disease. The increased biological relevance, cost-effectiveness and high-throughput of cell models can contribute to increase the efficiency of drug development in the pharmaceutical industry. Recapitulation of liver functionality in vitro requires the development of advanced culture strategies to mimic in vivo complexity, such as 3D culture, co-cultures or biomaterials. However, complex 3D models are typically associated with poor robustness, limited sca

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Costa, Daniela Filipa de Oliveira. "Hepatic differentiation of skin-derived stem cells and their application within in vitro toxicity testing." Master's thesis, 2016. http://hdl.handle.net/10451/34619.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Steatosis is the hepatic accumulation of lipids. Despite being the least severe stage of Non-Alcoholic fatty liver disease, evaluation of steatosis is a mechanistic assay for toxin-induced liver injury, mandatory for the development of new chemical entities. Toxin-induced liver injury represent a major concern to the pharmaceutical industry. The discontinuation of the development of new compounds, in addition with the withdrawal of market drugs, represent an immense economic imp

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Silva, Rui Gonçalo Teixeira da. "The effect of silver nanoparticles: a chronic in vivo study for the evaluation of hepatic mitochondrial toxicity." Master's thesis, 2014. http://hdl.handle.net/10316/28174.

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Dissertação de mestrado em Bioquímica, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Manufactured nanomaterials have been of extreme importance due to the beneficial physicochemical properties they possess compared to bulk parental materials. However, the properties that make them so attractive are also the same that can cause harm both to humans and environment. Over the last years there has been a rapid development of the nanotechnology industry and the inevitable human exposure tends rapidly to expand, accompanied by pot

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LU, WEI-HAN, and 呂維翰. "Dose-Volume Factors Analysis for Radiation-Induced Hepatic Toxicity in Patients with Hepatocellular Carcinoma after Radiotherapy." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/pan373.

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碩士<br>國立高雄科技大學<br>電子工程系<br>107<br>Purpose : To assess the dose-volume factors analysis of radiation - induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma (HCC) after radiotherapy. Materials and methods : The study is retrospectively collected between 2014 and 2017, 114 patients with HCC underwent intensity modulation radiation therapy (IMRT). Of those, liver dose - volume receiving of less than 700 cc and extreme value excluded with remain only 69 patients and to use the bootstrapping of reached 138 samples. Assess blood draw rises level during the course of the patient's

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Huang, Chi-Chang, and 黃啟彰. "Effects of Chronic Alcoholic Toxicity on Antioxidative Status and Hepatic Morphologic Changes by Lieber-DeCarli Animal Model." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/49349388686977521225.

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博士<br>臺北醫學大學<br>藥學系<br>93<br>This dissertation had two major parts; one was to evaluate the correlation between gender differences and chronic alcoholic liver disease. In addition, effects of gender differences on jejunal lipase and disaccharidase activities, the liver function tests, metabolic disorders and oxidative damage were also examined. Another major part was to examine oxidative stress of alcoholic injury and carbon tetrachloride- induced damage in relation to risk factors for liver disease. The first part of this study was to investigate the effects of gender differences on alcoholic

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Roquito, Tiago José Brasil. "The impact of curcumin-encapsulated glucan nanoparticles on hepatic cells and immune cells: oxidative stress and immunomodulatory properties." Master's thesis, 2021. http://hdl.handle.net/10316/99107.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>Nanotechnology is experiencing a rising interest from the pharmaceutical field due to the ability of nanoparticles (NPs) to increase the safety and efficiency of encapsulated drugs. Curcumin is a polyphenol with great therapeutic properties, especially regarding its anti-cancer abilities. However, its pharmacokinetics are poor, having poor bioavailability and being rapidly metabolized and excreted in vivo. The NPs chosen to overcome the curcumin’s poor pharmacokinetics were glucan NPs, as glucan has gr

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