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Journal articles on the topic 'Hepatic Toxicity and CCl4'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Mohammed, Usman, Abdulrashid Mohammed, Daniel Hassan Mhya, Simon Mafulul Gabriel, and Daniel Dahiru. "Protective Efficiency of Pterocarpus erinaceus Leaves Extract in Carbon-tetrachloride-induced Hepatic and Hematological Injuries in Rats." Journal of Applied Life Sciences International 26, no. 3 (2023): 41–52. http://dx.doi.org/10.9734/jalsi/2023/v26i3606.

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Aims: Chemical toxicity is one of the major leading causes of tissues injuries, which impair the tissue’s ability to maintain normal physiological functions. Pterocarpus erinaceus is a medicinal plant use as traditional remedy for the treatment of several disorders associated with tissues injuries. This study therefore aimed at investigating tissues protective efficiency of Pterocarpus erinaceus leaves extract in carbon-tetrachloride-induced hepatic and hematological injuries in rats. Materials and Methods: Leaves of Pterocarpus erinaceous after collection were air-dried and pulverized.

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Shah, Muhammad Dawood, Senty Vun-Sang, and Mohammad Iqbal. "Phenolic Content, Antioxidant and Hepatoprotective Activities of Sabah Hoya coronaria Blume." Journal of Tropical Biology & Conservation (JTBC) 20 (October 15, 2023): 203–17. http://dx.doi.org/10.51200/jtbc.v20i.4656.

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A common challenge that regularly results from oxidative stress is hepatic damage. This condition is characterised by a gradual progression from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The study proposed to assess the antioxidant activity and efficacy of Hoya coronaria aqueous extract in preventing CCl4-induced hepatic damage in rats. The DPPH technique was used in the study to assess the extract's antioxidant properties. The rats received dosages of 125 and 250 mg/kg body weight of H. coronaria extract for 14 days, followed by CCl4 exposure. After tw

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El-Bialy, Badr E., Neveen G. El-Boraey, Ragaa A. Hamouda, and Mohamed M. Abdel-Daim. "Comparative Protective Effects of Spirulina and Spirulina Supplemented with Thiamineagainst Sub-acute Carbon Tetrachloride Toxicity in Rats." Biomedical and Pharmacology Journal 12, no. 2 (2019): 511–26. http://dx.doi.org/10.13005/bpj/1670.

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Carbon tetrachloride (CCl4) is used extensively as an industrial solvent and considered the best-characterized experimental animal model of xenobiotic-induced hepatic toxicity via reactive oxygen species (ROS) generation. This study was designed to evaluate the protective effects of Spirulina platensis (SP) versus Spirulina platensis supplemented with thiamine (SPt) against subacute CCl4 toxicity in rats. Rats were divided into six equal groups; Control vehicle (0.5 ml/rat 1:1 olive oil in water), SP (800 mg/kg b.wt.), SPt (800 mg/kg b.wt.), CCl4 (1ml/kg b.wt.), SP + CCl4 and SPt + CCl4. All t

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Touiss, Ilham, Sabir Ouahhoud, Mohamed Harnafi, et al. "Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L." Evidence-Based Complementary and Alternative Medicine 2021 (January 31, 2021): 1–10. http://dx.doi.org/10.1155/2021/6676998.

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Exposure to carbon tetrachloride (CCl4) induces acute and chronic liver injuries as well as oxidative stress in rats. The present study was designed to evaluate the in vivo toxicity of rosmarinic acid-rich extract from Ocimum basilicum (RAE). The acute and subchronic oral toxicity of RAE was evaluated in Albinos mice. Hepatotoxicity was induced by the administration of CCl4-induced hepatic injury in rats. The hepatoprotective effect of RAE on aspartate aminotransferase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, bilirubin, total protein, albumin, triglycerides, total ch

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Jadeja, Ravirajsinh N., Menaka C. Thounaojam, Ansarullah, et al. "Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract." Human & Experimental Toxicology 30, no. 1 (2010): 63–70. http://dx.doi.org/10.1177/0960327110368420.

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This inventory evaluates toxicological effects and hepatoprotective potential of Clerodendron glandulosum.Coleb (CG) aqueous extract. Acute and subchronic toxicity tests were performed using Swiss albino mice as per the guideline of Organisation for Economic Cooperation and Development (OECD). Also, hepatoprotective potential of CG extract was examined in experimental model of carbon tetrachloride (CCl 4)-induced hepatotoxicity. Acute and subchronic toxicity tests revealed that CG extract is non-toxic and its median lethal dose (LD50) value is >5000 mg/kg bodyweight. Also, rats pretreated w

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Roomi, MW, T. Kalinovsky, NW Roomi, V. Ivanov, M. Rath, and A. Niedzwiecki. "A nutrient mixture suppresses carbon tetrachloride–induced acute hepatic toxicity in ICR mice." Human & Experimental Toxicology 27, no. 7 (2008): 559–66. http://dx.doi.org/10.1177/0960327108096851.

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We examined the effect of a nutrient mixture (NM) that contains lysine, proline, ascorbic acid, and green tea extract in mice treated with carbon tetrachloride (CCl4), a model of liver injury in which free radical, oxidative stress, and cytokine production are closely linked. Seven-week-old male Imprinting Control Region (ICR) mice were divided into four groups (A–D) of five animals each. Groups A and C mice were fed a regular diet for 2 weeks, whereas groups B and D mice were supplemented with 0.5% NM (w/w) during that period. Groups A and B received corn oil i.p., whereas groups C and D rece

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Alzahrani, Sabah Ali, Gamal M. Bekhet, Rebai Ben Ammar, et al. "The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway." Saudi Journal of Medicine & Medical Sciences 12, no. 1 (2024): 17–26. http://dx.doi.org/10.4103/sjmms.sjmms_225_23.

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Abstract Background: Hepatotoxicity caused by CCL4 is well known. Geraniol (GNL) has high antioxidant effect that can induces liver regeneration. However, the protective effect of GNL effect on CCL4-induced hepatorenal toxicity in pregnant mice has not yet been studied. Objective: To investigate whether GNL could protect against oxidative stress induced by CCL4 via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which is regulated by phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT), and has been found to have protective effects on renal and hepatic tissues. Materials a

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A. Aziz, Tavga, Zheen A. Ahmed, Kasim M. Juma'a, Munaf H. Abdulrazzaq, Saad A. Hussain, and Saad A. Hussain. "Study of the Protective Effects of Benfotiamine Against CCl4-Induced Hepatotoxicity in Rats." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 47–53. http://dx.doi.org/10.31351/vol18isssuppl.pp47-53.

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Liver is considered as the first target for the toxic effects of toxins and other xenobiotics, and this can be attributed to its role as a site which receive all absorbed xenobiotics from the gastrointestinal tract and its role as a major site for biotransformation of xenobiotics. The present study was designed to evaluate the possible hepatoprotective effect of benfotiamine against CCl4-induced hepatotoxicity in rats. The study was conducted on 48 male albino rats; the animals were allocated into 8 groups (6 rats in each group) and treated as follow: 4 groups treated with oral doses of either

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Bellassoued, Khaled, Ferdaws Ghrab, Houda Hamed, et al. "Protective effect of essential oil of Cinnamomum verum bark on hepatic and renal toxicity induced by carbon tetrachloride in rats." Applied Physiology, Nutrition, and Metabolism 44, no. 6 (2019): 606–18. http://dx.doi.org/10.1139/apnm-2018-0246.

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The inner bark of cinnamon (Cinnamomum verum) is widely used as a spice. Cinnamon plants are also a valuable source of essential oil used for medicinal purposes. The present study aimed to investigate the composition and in vitro antioxidant activity of essential oil of C. verum bark (CvEO) and its protective effects in vivo on CCl4-induced hepatic and renal toxicity in rats. Groups of animals were pretreated for 7 days with CvEO (70 or 100 mg/kg body weight) or received no treatment and on day 7 a single dose of CCl4 was used to induce oxidative stress. Twenty-four hours after CCl4 administra

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Ebaid, Hossam, Jameel Al-Tamimi, Iftekhar Hassan, et al. "Effect of Selenium Nanoparticles on Carbon Tetrachloride-Induced Hepatotoxicity in the Swiss Albino Rats." Applied Sciences 11, no. 7 (2021): 3044. http://dx.doi.org/10.3390/app11073044.

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Background: This study investigated selenium nanoparticles’ protective effects (SE-NPs) against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Methods: Rats were divided into four groups (n = 8). Group 1 rats received the vehicle solution only. Group 2 received a single intraperitoneal injection of 1 mL/kg CCl4 in liquid paraffin (1:1 v/v). Group 3 was treated with SE-NPs (2.5 mg/kg) twice a week for three weeks before receiving CCl4 challenge. Oxidative stress, liver function, liver histopathology and serum lipid levels were evaluated. Results: Plasma concentrations of aspartate

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Rao, S. B., and H. M. Mehendale. "Protective role of fructose 1,6-bisphosphate during CCl4 hepatotoxicity in rats." Biochemical Journal 262, no. 3 (1989): 721–25. http://dx.doi.org/10.1042/bj2620721.

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Rats were injected intraperitoneally with CCl4 (2.5 ml/kg body wt.) and the hepatotoxicity was compared with that of rats receiving the same dose of CCl4 and an intraperitoneal injection of fructose 1,6-bisphosphate (2 g/kg body wt.). A 50-70% decrease in plasma aspartate aminotransferase and alanine aminotransferase activities was observed in the latter treatment, indicating a protective role of the sugar bisphosphate in CCl4 hepatotoxicity. The protection was accompanied by elevated hepatic activities of ornithine decarboxylase at 2, 6 and 24 h, S-adenosylmethionine decarboxylase at 6 h, and

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Alkinani, Khadijah B., Ehab M. M. Ali, Turki M. Al-Shaikh, et al. "Hepatoprotective Effects of (−) Epicatechin in CCl4-Induced Toxicity Model Are Mediated via Modulation of Oxidative Stress Markers in Rats." Evidence-Based Complementary and Alternative Medicine 2021 (December 22, 2021): 1–12. http://dx.doi.org/10.1155/2021/4655150.

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Objective. (−) Epicatechin (EP) is a naturally occurring antioxidant flavonoid found in some green plants. The current study was designed to evaluate the potential role of antioxidant mechanisms in the hepatoprotective properties of EP using the carbon tetrachloride (CCl4)-induced acute liver injury model. Materials and Methods. Rats (n = 7 per group) were divided into five groups including control group, (−) epicatechin group (20 mg·kg−1 body weight), CCl4 group (1 mL−1 body weight), CCl4-EP treatment group, and CCl4-silymarin (SILY) group. The levels of enzymes including hepatic malondialdeh

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Mughal, Tafail Akbar, Shaukat Ali, Shazia Khatoon, Saeed Khalil, and Shumaila Mumtaz. "Protective effect of Helianthus annuus seeds extract against CCl4-induced hepatocellular damage." Pakistan Journal of Biochemistry and Biotechnology 4, no. 2 (2023): 37–45. http://dx.doi.org/10.52700/pjbb.v4i2.97.

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Carbon tetrachloride (CCl4) is a hepatotoxin that causes toxicity in animals on its exposure. Hepatotoxins lead to hepatic demage that is treated by generating antioxidant effect. Synthetic and as well as natural drugs are available for this purpose but phyto-based herbal medicines got paramount importance against drug induced hepatotoxicity Current research was conducted to inspect the protective effect of aqueous extract of Helianthus annuus seeds pre-treatment on the carbon tetrachloride-induced hepatotoxicity in Balb C mice. Study covered the valuation of the enzymatic activity such as ala

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14

Ullah, Riaz, Mansour S. Alsaid, Abdelaaty A. Shahat, et al. "Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats." Open Chemistry 16, no. 1 (2018): 133–40. http://dx.doi.org/10.1515/chem-2018-0021.

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AbstractThe detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of safe hepatoprotective agents remains an unmet need. Therefore, we investigated the antioxidant effects of methanolic and n-hexane fractions of Zilla spinosa (ZSM and ZSH, respectively) and Hammada elegans (HEM and HEH, respectively) against carbon tetrachloride (CCl4)-induced liver toxicity in rats. Antioxidant activity was studied by the 2,2-diphenyl-

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Udavant, Pavan, Pragati Gurav, Gayatri Kanade та ін. "Evaluation of Hepatoprotective and Nephroprotective Effect of Α- Pinene on Wistar Albino Rat". Biomedical and Pharmacology Journal 16, № 1 (2023): 103–12. http://dx.doi.org/10.13005/bpj/2592.

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Introduction: Hepato-renal toxicity is a devastating, non-communicable disease. Because of a lack of information on low-cost management to combat the disease, this study postulates the ameliorative effect of selected phytoconstituents against toxicity. Aim and Objective: The current study reveals an active phytoconstituent, α- Pinene, that has the ability to combat the degenerative effects of CCl4. Methodology: Carbon tetrachloride (CCl4) is an organic xenobiotic molecule as well as the most potent hepatotoxic agent used (1200 mg/kg body weight; i.p.) to induce hepato-renal toxicity in experim

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Ekor, Martins, Adesina O. Odewabi, Oluwafemi E. Kale, Kolawole S. Oritogun, Omolola A. Adesanoye, and Titilayo O. Bamidele. "Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats." Human & Experimental Toxicology 30, no. 11 (2011): 1840–48. http://dx.doi.org/10.1177/0960327111401051.

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The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in CCl4-induced liver injury with a view to ascertaining the chemopreventive benefit. Fifty-six Wistar albino rats were divided into eight experimental groups of seven rats/group. Groups 1–4 received normal saline

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Alqahtani, Nashi K., Hisham A. Mohamed, Mahmoud E. Moawad, Nancy S. Younis, and Maged E. Mohamed. "The Hepatoprotective Effect of Two Date Palm Fruit Cultivars’ Extracts: Green Optimization of the Extraction Process." Foods 12, no. 6 (2023): 1229. http://dx.doi.org/10.3390/foods12061229.

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Date palm fruit (Phoenix dactylifera: Arecaceae) is rich in essential nutrients and possesses several pharmacological and medicinal activities. The current study aimed to optimize a water bath-assisted extraction method for two cultivars of date palm fruits, Anbara (An) and Reziz (Rz), and investigated the protective effect of the optimized date palm fruit extract against CCl4-induced liver toxicity in relation to oxidative stress, inflammation, apoptosis, and DNA integrity. The optimization process of two date palm fruit cultivars was applied, using response surface methodology through adjust

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Kovacevic, Zoran, Goran Davidovic, Jelena Vuckovic-Filipovic, Mirjana A. Janicijevic-Petrovic, Katarina Janicijevic, and Andrijana Popovic. "A Toxic Hepatitis Caused the Kombucha Tea – Case Report." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (2014): 128–31. http://dx.doi.org/10.3889/oamjms.2014.023.

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Background: Toxic hepatitis may clinically manifest as other diseases of the liver, where it must always be considered in differential diagnoses of unexplained liver damage, such as poisoning with kombucha tea.Case report: 47-year old female patient was hospitalized and has consumed daily ounces of kombucha tea. During hospitalization patient was diagnosed with toxic hepatitis and treated with intravenous solutions of hepatic protective and ursodeoxycholic-acid (effective therapy). Conclusion: Examinations showed that kombucha tea has potential to revert the CCl4-induced hepatic toxicity, but

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Almohmadi, Najlaa, Ahmed Aldhalmi, Mona Zahran, et al. "Hepatoprotective efficacy of Lagenaria siceraria seeds oil against experimentally carbon tetrachloride-induced toxicity." Open Veterinary Journal 14, no. 8 (2024): 2016. http://dx.doi.org/10.5455/ovj.2024.v14.i8.31.

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Background: The liver is crucial for maintaining normal metabolism in the body. Various substances, such as toxic chemicals, drugs, and alcohol, can damage hepatocyte cells, leading to metabolic imbalances. Aim: The experiment aimed to determine the efficacy of Lagenaria siceraria seed oil (LSS) as a hepatoprotective agent against acute hepatotoxicity triggered by carbon tetrachloride (CCl4). Methods: A total of 20 rats were randomly separated into four groups. The control group: rats received 2 ml of distilled water orally, followed by 1.25 ml of olive oil intraperitoneally (i.p.) after 30 mi

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Saxena, Sneha, Lata Shahani, and Pradeep Bhatnagar. "HEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 273. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20918.

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Objective: To study the effect of Quinoa seed on carbon tetrachloride (CCL4)-induced liver toxicity in Swiss albino male mice.Methods: Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl4-treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosph

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Sreena, Raj, and M. Gothandam K. "Hepatoprotective and antioxidant activity of aqueous extract of Amorphophallus commutatus var. wayanadensis." Journal of Indian Chemical Society Vol. 92, Apr 2015 (2015): 545–48. https://doi.org/10.5281/zenodo.5596217.

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School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail</em> : gothandam@yahoo.com Amorphophallus commutatus var. wayanadensis is a red listed medicinal plant which has been used traditionally in Wayanad, India for various ailments like hemorrhoids and tumors. The hepatoprotective and antioxidant activity of aqueous extract of Amorphophallus commutatus var. wayanadensis (AEAC) was evaluated against carbon tetrachloride (CCl<sub>4</sub> ) induced hepatotoxicity in swiss albino mice models. Hepatoprotective potential of AEAC was determined by estimating

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Alqasoumi, Saleh. "Carbon Tetrachloride-Induced Hepatotoxicity: Protective Effect of 'Rocket' Eruca sativa L. in Rats." American Journal of Chinese Medicine 38, no. 01 (2010): 75–88. http://dx.doi.org/10.1142/s0192415x10007671.

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The hepatoprotective and antioxidant effect of an ethanolic extract of 'Rocket' Eruca sativa L. (EER), on liver injury induced by carbon tetrachloride ( CCl4 ) was investigated. Wistar albino rats were administered 250 and 500 mg/kg body weight extract orally for 10 consecutive days. Marker enzymes GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Whereas, non-protein sulfhydryl (NP-SH), total protein (TP) and malondialdehyde (MDA) were estimated in liver tissue as markers for oxidative stress. Histopathological assessment was also done on liver tissue. CCl4 induced liver poisoning in

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Asmaa, Abdulaziz Ahmeedah Rabee *. and Hassen A.H. Bennasir. "HESPERIDIN (HDN) AN ANTIOXIDANT FLAVONOID PREVENTS CARBON TETRACHLORIDE (CCl4) - INDUCED ‎HEPATIC TOXICITY IN MALE ALBINO RATS." Journal of Pharma Research 7, no. 12 (2018): 283–89. https://doi.org/10.5281/zenodo.2529174.

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<strong><em>ABSTRACT</em></strong> <strong><em>Background: </em></strong><em>Through this research work, an experimental study was conducted to evaluate the protective effects of an antioxidant (Hesperidin) on carbon tetrachloride-induced hepatic toxicity. This effect was evaluated through assessment of liver functions as well as histopathological changes in livers of rats exposed to Hesperidin prior to carbon tetrachloride.</em> <strong><em>Materials and Methods: </em></strong><em>Thirty two male albino rats (160-200 gm) were chosen as an animal model for this study and distributed to four eq

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Tsai, Meng-Tsz, Ching-Yi Chen, Yu-Hui Pan, Siou-Huei Wang, Harry J. Mersmann, and Shih-Torng Ding. "Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/725379.

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Betaine is a food component with well-reported hepatoprotection effects. However, the effects and mechanisms of betaine on liver fibrosis development are still insufficient. Because metabolic functions of chicken and human liver is similar, we established a chicken model with carbon Tetrachloride- (CCl4-) induced fibrosis for studying antifibrotic effect of betainein vivoandin vitro. Two-week-old male chicks were supplemented with betaine (1%, w/v) in drinking water for 2 weeks prior to the initiation of CCl4treatment (i.p.) until sacrifice. Primary chicken hepatocytes were treated with CCl4an

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Marques, Thamirys Guimarães, Eleazar Chaib, Juliana Hamati da Fonseca, et al. "Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection." Acta Cirurgica Brasileira 27, no. 8 (2012): 589–94. http://dx.doi.org/10.1590/s0102-86502012000800013.

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PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after in

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Salwa, S. Soliman, and El-mohsen M. Soliman Abd. "Ameliorative Effect of Ethanolic Extract from Cicer arietinum Seeds towards CCl4-Induced Liver Hepatotoxicity in Rats." Chemistry Research Journal 6, no. 2 (2021): 125–32. https://doi.org/10.5281/zenodo.11649770.

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<strong>Abstract </strong>The ameliorative effect of the ethanolic extract from<em>Cicer arietinum</em> (Chickpea) seedstowards the CCl<sub>4</sub>-induced hepatotoxicity in male Wistar rats through measuring certain biochemical parameters content in the liver were analyzed. The CCl<sub>4</sub>-treated rats showed a significant decline in the studied the serum levels of high-density lipoprotein (HDL), albumin (A) as well as the hepatic levels of glutathione (GSH) and activities of catalase (CAT), superoxide dismutase (SOD) , glutathione reductase (GR), elevation in the levels of total lipids (

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Khan, Muhammad Zakryya, Muhammad Imran Shabbir, Zafeer Saqib, et al. "Investigation of polyphenol profile, antioxidant activity and hepatoprotective potential of Aconogonon alpinum (All.) Schur roots." Open Chemistry 18, no. 1 (2020): 516–36. http://dx.doi.org/10.1515/chem-2020-0062.

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AbstractLiver plays vital role in detoxification of exogenous and endogenous chemicals. These chemicals as well as oxidative stress may cause liver disorders. This study was aimed to evaluate the hepatoprotective effects of various fractions of Aconogonon alpinum methanolic extract against carbon tetrachloride (CCl4)-induced liver toxicity in mice. First, hepatoprotective potential of various fractions of A. alpinum was assessed and then antioxidant activity and profiling of polyphenolic compounds were assessed. A total of 78 male albino mice (BALB/c) were randomly divided into 13 groups (n =

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Alamri, Eman S., Haddad A. El Rabey, Othman R. Alzahrani, et al. "Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CCl4) Hepatotoxicity in Male Rats by the Synthesis of Silver Nanoparticles (AgNPs)." Molecules 27, no. 23 (2022): 8308. http://dx.doi.org/10.3390/molecules27238308.

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In the current study, the hepatoprotective activity of vanillic acid, silymarin, and vanillic acid-loaded silver nanoparticles (AgNPs) against CCl4-induced hepatotoxicity was tested in male rats for four weeks. Thirty male rats were divided into five groups (n = 6). The 1st group was a negative control, the 2nd group was a positive control, the 3rd group was treated with 100 mg/kg b.w. of vanillic acid, the 4th group was treated with 100 mg/kg b.w. of vanillic acid–AgNPs, and the 5th group was treated with 50 mg/kg b.w. of silymarin. The CCl4-induced hepatic toxicity in the 2nd group was revea

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Kazmi, Arsheema, Abeer Kazmi, Sulaiman Shams, Abdul Sajid, and Khalid Khan. "Therapeutic role of bone marrow-derived stem cells and zinc sulfate for reduction of liver fibrosis." Progress in Stem Cell 6, no. 2 (2019): 269–78. http://dx.doi.org/10.15419/psc.v6i1.406.

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Introduction: Hepatic fibrosis is considered as the initial state of any chronic hepatic disease; progression causes accumulation of extracellular matrix (ECM) and develops into cirrhosis. In case of liver failure, transplantation was considered as the only suitable therapy but due to the hurdles in transplantation, therapy using stem cells was promoted. Mesenchymal stem cells (MSCs) are widely used for the treatment of a variety of diseases. Oxidative stress at the damage site causes poor MSC proliferation and engraftment. Thus, it is necessary to induce antioxidants with MSCs to enhance pote

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Olatoye, Raphael S., and Oluwatosin A. Adaramoye. "Methanol Leaf Extract of Voacanga Africana Protects Against Diethylnitrosamine and Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats via Antioxidant and Anti-Inflammatory Activities." Scholars International Journal of Biochemistry 8, no. 01 (2025): 1–17. https://doi.org/10.36348/sijb.2025.v08i01.001.

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Background: Hepatotoxicity induced by chemical agents is a common and life-threatening disease that developed from acute or chronic exposure to environmental chemicals. Despite numerous approaches towards the treatment of liver toxicity, no safe and effective therapy exists. This study evaluated the antioxidative and anti-inflammatory effects of methanol leaf extract of Voacanga africana (VA) in diethylnitrosamine (DEN) and carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The animals were assigned into seven groups: Control, [DEN+CCL4], [DEN+CCL4] with VA (100, 200, 400 mg/kg), [DEN

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Vanitha, A., K. N. Chidambara Murthy, Vinod Kumar, et al. "Effect of the Carotenoid-Producing Alga, Dunaliella bardawil, on CCl4-Induced Toxicity in Rats." International Journal of Toxicology 26, no. 2 (2007): 159–67. http://dx.doi.org/10.1080/10915810701224748.

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Dunaliella bardawil is a carotenoid-producing alga that is being considered for use in nutraceuticals. To evaluate potential protective effects of consumption of this alga, rats were treated with two different doses of D. bardawil (2.5 and 5.0 g kg–1 body weight [bw]) as a biomass suspension daily for 14 days. Animals were tested against Carbon tetrachloride (CCl4; 2 ml kg–1)–induced liver toxicity as measured by various biochemical marker enzymes in liver and blood. All measurements were taken 6 h following the single dose of CCl4. The results of this study show that there was a slight, but s

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Ali, Maroof, Hidayat Hussain, Amjad Hussain, et al. "Hepatoprotective Screening of Seriphidium kurramense (Qazilb.) Y.R. Ling." BioMed Research International 2021 (December 6, 2021): 1–11. http://dx.doi.org/10.1155/2021/9026731.

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Investigation on medicinal plants’ therapeutic potential has gained substantial importance in the discovery of novel effective and safe therapeutic agents. The present study is aimed at investigating the hepatoprotective potential of Seriphidium kurramense methanolic extract (SKM) against carbon tetrachloride- (CCl4-) induced hepatotoxicity in rats. S. kurramense is one of the most imperative plants for its various pharmacological activities. Therefore, this study was aimed at evaluating the hepatoprotective potential against CCl4-induced liver toxicity. The serum samples were analyzed for ala

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Ammar, Naglaa M., Heba A. Hassan, Heba M. I. Abdallah, et al. "Protective Effects of Naringenin from Citrus sinensis (var. Valencia) Peels against CCl4-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses." Nutrients 14, no. 4 (2022): 841. http://dx.doi.org/10.3390/nu14040841.

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Citrus fruits are grown worldwide for their special nutritive and several health benefits. Among citrus bioactives, naringenin, a major flavanone, exhibits a potential hepatoprotective effect that is not fully elucidated. Herein, serum biochemical parameters and histopathological assays were used to estimate the hepatoprotective activity of naringenin, isolated from Citrus sinensis (var. Valencia) peels, in CCl4-induced injury in a rat model. Further, GC–MS-based untargeted metabolomics was used to characterize the potential metabolite biomarkers associated with its activity. Present results r

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Jahan, Ishrat, Md Didarul Islam, Sumaia Sarif, et al. "Tempol Alters Antioxidant Enzyme Function, Modulates Multiple Genes Expression, and Ameliorates Hepatic and Renal Impairment in Carbon Tetrachloride (CCl4)-Intoxicated Rats." Livers 3, no. 1 (2023): 105–20. http://dx.doi.org/10.3390/livers3010010.

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The purpose of this study was to determine the effect of the superoxide dismutase mimic compound “tempol” on liver and renal damage in Long Evans male rats administered with carbon tetrachloride (CCl4). Methods: The antioxidant enzyme activity and oxidative stress parameters were investigated in the liver, kidney, and plasma tissues. Histological examination of the liver and kidney sections affirmed inflammatory cell infiltration, collagen deposition, and iron deposition. RT-PCR was also employed to evaluate the expression of oxidative stress and inflammatory genes. Results: The CCl4-administe

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A-Ani, Zaid S. M., Sana A. Abdulmawjood, Adel O. A. Al-Hussain, and Shihab A. Al-Bajari. "Synthesis and Biological Activity of few Pyrimidines Derivatives against Hepatic Injury Stimulated by Carbon Tetrachloride in Male Rats." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1496–501. http://dx.doi.org/10.25258/ijddt.12.4.02.

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In the presence of sodium hydroxide, substituted chalcones are reacted with cyanoguandine in ethanol, and some chalcone compounds are used as a nucleus in the preparation of some five-, hexa-, and hepta-, heterocyclic compounds pyrimidine (pyrimidines derivatives), pyrimidine derivatives (A1, A2, and A3). Contains therapeutic properties and bioactivity, and has been used to treat various ailments. This study aimed to learn more about how pyrimidine derivatives could help mitigate the undesirable implications of carbon tetrachloride. a group of 50 male rats were separated into 5 groups: healthy

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Das, Madhubanti, Juri Konwar, and Jogen Chandra Kalita. "HEPATOPROTECTIVE ACTIVITY OF HOMALOMENA AROMATICA AGAINST CCL4 INDUCED LIVER INJURY IN SWISS ALBINO MICE." International Journal of Advanced Research 11, no. 01 (2023): 676–83. http://dx.doi.org/10.21474/ijar01/16066.

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The in vivo hepatoprotective activity of Homalomena aromatica was evaluated in carbon tetrachloride-induced hepatic injury model in Swiss albino mice. Effects of the methanolic rhizome extracts of Homalomena aromatica (HAME) at a dose of 200 mg/kg body weight and 500 mg/kg body weight was tested for its efficacy on CCl4 (1ml/kg body weight) induced liver injury. Hepatic toxicity enzyme markers and histological parameters were studied. Daily oral administration of HAME (500 mg/kg) reduced liver toxicity marker enzyme activity significantly as compared to the control. The results were also suppo

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Naz, Falak, Humaira Imtiaz, Sumaira Javed, et al. "HEPATOPROTECTIVE ROLE OF n- HEXANE FRACTION AND CRUDE METHANOLIC EXTRACT OF WITHANIA COAGULANS IN BALB C MICE –A HISTOLOGICAL STUDY." Journal of Ayub Medical College Abbottabad 34, no. 4(SUPPL 1) (2022): 932–35. http://dx.doi.org/10.55519/jamc-04-s4-10128.

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Background: Withania coagulans is one of the most important medicinal herbs due to its wide range of biological activities. The aim of this study was to compare the hepatoprotective activity of crude methanolic extract versus n- hexane fraction of fruit of Withania coagulans in CCl4 induced liver toxicity Methods: This study was done on 36 Balb c mice in Department of Anatomy of Khyber Medical College Peshawar. Results: The mean serum of Group 1(control Group) was 33.41±1.82U/L, for Group 2 (CCl4 treated Group) was 89.01±7.51 U/L, for Group 3(low dose Group) was 49.91±3.48 U/L and for Group 4

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Abdel-Salam, Omar M. E., Nermeen M. Shaffie, Nadia A. Mohammed, Eman R. Youness, Safaa M. Youssef Morsy, and Amany A. Sleem. "The 5-HT1A Agonist Buspirone Decreases Liver Oxidative Stress and Exerts Protective Effect Against CCl4– Toxicity." Journal of Experimental and Clinical Toxicology 1, no. 1 (2017): 13–26. http://dx.doi.org/10.14302/issn.2641-7669.ject-17-1789.

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We aimed to study the effect of buspirone, an anxiolytic drug and 5-HT1A agonist on liver injury induced by carbon tetrachloride (CCl4) in rats. Rats were orally treated with CCl4 (2.8 mL/kg in olive oil) along with buspirone at 10, 20 or 30 mg/kg once daily starting with CCl4 and for one week thereafter. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as well as alkaline phosphatase (ALP) activities were determined in the serum. Markers of oxidative stress: lipid peroxidation (malondialdehyde; MDA), reduced glutathione (GSH), nitric oxide (nitrite/nitrate) levels were meas

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Frank, H., D. Thiel, and J. MacLeod. "Mass spectrometric detection of cross-linked fatty acids formed during radical-induced lesion of lipid membranes." Biochemical Journal 260, no. 3 (1989): 873–78. http://dx.doi.org/10.1042/bj2600873.

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A mass spectrometric method is described for the quantitative determination of dimers of polyunsaturated fatty acids (PUFA) formed in the hepatic endoplasmic reticulum of rats upon inhalation of tetrachloromethane. The results show that dimers account for a considerable fraction of microsomal PUFA which disappear during CCl4 metabolism. Cross-linking of the membrane lipids of the endoplasmic reticulum seems to be a significant process with respect to cell toxicity.

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Bilegsaikhan, Zolzaya, Dejidmaa Buyantogtokh, Erdenechimeg Chuluunbaatar, et al. "Hepatoprotective Activity of the Odontites vulgaris Moench herb Against Carbon Tetrachloride Toxicity and Evaluating its Standardization Parameters." Biomedical and Pharmacology Journal 18, no. 1 (2025): 965–76. https://doi.org/10.13005/bpj/3145.

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O.vulgaris Moench is known for its medicinal properties, mainly to remove blood fever and inflammation. The extent of investigation aims to study the activity of O.vulgaris (OV), a medicinal plant, on hepatic acute injury-induced CCl4 in rats and establish the requirements of the standard for this medicinal plant. Wistar rats were induced to the CCl4 model with or without OV (112, 224, 560 mg/kg b.w) co-administration for 7 days. Identifications for standardization study were that the diagnostic cellular structures in O vulgaris were defined by light microscopy, and apigenin, luteolin, and auc

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S P, Abhiram, Oorvi Kulkarni, Chinky Goyal, and Amrit Malik. "In vivo study of Rasa Bhasma on CCL4 induced Hepato-toxicity in Albino rats." International Journal of Ayurvedic Medicine 12, no. 4 (2021): 918–21. http://dx.doi.org/10.47552/ijam.v12i4.2164.

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India stands 27th in rank with 25.8% of death rate due to Liver diseases in 2016. In spite of scientific advancement in the field of Hepatology, Bio-medical science is clueless in finding out an effective drug against Hepatic Disorders. Detailed description on liver disorders and their management are given by all the three prominent Acharyas of Ayurveda. Rasa Bhasma is one such preparation that can be used to treat Hepatic Disorders. In present work an attempt has been made to evaluate the efficacy of Rasa Bhasma in the management of liver disorders. 24 animals were allocated into 4 groups hav

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Hira, Syeda, Muhammad Gulfraz, S. M. Saqlan Naqvi, Rehmat Ullah Qureshi, and Hina Gul. "Protective effect of leaf extract of Ficus carica L. against carbon tetrachloride-induced hepatic toxicity in mice and HepG2 cell line." Tropical Journal of Pharmaceutical Research 20, no. 1 (2021): 113–19. http://dx.doi.org/10.4314/tjpr.v20i1.17.

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Purpose: To determine the in vivo and in vitro hepatoprotective effects of Ficus carica.Methods: The methanol leaf extract of Ficus carica L was further fractionated into n-hexane, ethyl acetate and aqueous fractions. For in vivo study, male albino mice were divided into twelve groups. Hepatotoxicity was induced in the mice using carbon tetrachloride (CCl4). The extract of F. carica and its fractions were administered at doses of 200 and 400 mg/kg. Silymarin was used as standardhepatoprotective drug. The protective effects of the extract and fractions were determined via assay of biochemical p

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Gao, Jing, Huan Dou, Xin-Hui Tang, Li-Zhi Xu, Yi-Mei Fan, and Xiao-Ning Zhao. "Inhibitory Effect of TCCE on CCl4-induced Overexpression of IL-6 in Acute Liver Injury." Acta Biochimica et Biophysica Sinica 36, no. 11 (2004): 767–72. http://dx.doi.org/10.1093/abbs/36.11.767.

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Abstract Terminalia catappa L. leaves have been shown to protect against acute liver injury produced by some hepatotoxicants, but the active components and mechanisms are not clear. This study was designed to characterize the protective effects of the chloroform fraction of the ethanol extract of T. catappa leaves (TCCE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (IL-6) in the process. It was found that TCCE pretreatment (10 or 30 mg/kg, ig) protected mice from CCl4 toxicity, as evidenced by the reversed alte

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Yaduma, Gaiuson Wandiahyel, Hickson Sekari, Samuel Thagriki Dluya, and Nachamada Solomon Emmanuel. "Medicinal Potential of Kigelia africana Leaf Fractions on Rats Induced CCl4 Toxicity." Chemistry Research Journal 3, no. 3 (2018): 123–29. https://doi.org/10.5281/zenodo.13904126.

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The study aimed at determining the protective effect of <em>K. africana</em> leaf fractions on serobiochemical parameters and histological examination of liver section of rat induced carbon tetrachloride (CCl<sub>4</sub>) toxicity. A total of 35 male rats were used for the study. The rats were divided into seven groups, each group having five rats. Group 1 (normal), Group 2 (drug control), Group 3 (CCl<sub>4</sub> control) while Group 4, 5, 6 and 7 were administered with fractions 1, 2, 3 and 4 at 100 mg/kg/day/body weight for 7 days and induced with CCl<sub>4 </sub>intraperitonealy. Changes i

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Lin, Shi-Yu, Xu Dan, Xia-Xia Du, et al. "Protective Effects of Salidroside against Carbon Tetrachloride (CCl4)-Induced Liver Injury by Initiating Mitochondria to Resist Oxidative Stress in Mice." International Journal of Molecular Sciences 20, no. 13 (2019): 3187. http://dx.doi.org/10.3390/ijms20133187.

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The antioxidant effect of salidroside has been proven, but its role in liver injury is poorly understood. In this study, we aimed to evaluate the protective effects and mechanism of salidroside on liver injury induced by carbon tetrachloride (CCl4) in vivo. Mice were pretreated with salidroside (60 mg/kg, intraperitoneally injected, i.p.) once per day for 14 consecutive days and then administered with CCl4 (15.95 g/kg, i.p.) for 24 h to produce a liver injury model. Salidroside attenuated hepatic transaminase elevation in serum and ameliorated liver steatosis and necrosis, thereby suggesting i

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Aati, Hanan Y., Mahmoud Emam, Jawaher Al-Qahtani, et al. "Chemical Composition of Tagetes patula Flowers Essential Oil and Hepato-Therapeutic Effect against Carbon Tetrachloride-Induced Toxicity (In-Vivo)." Molecules 27, no. 21 (2022): 7242. http://dx.doi.org/10.3390/molecules27217242.

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The liver is a crucial organ among body organs due to its wide functions, in particular, detoxification and metabolism. Exposure to detrimental chemicals or viral infections may provoke liver dysfunction and ultimately induce liver tissue damage. Finding natural substances for liver disease treatment to overcome the conventional treatments’ side effects has attracted the attention of researchers worldwide. Our current work was conducted to investigate the hepato-therapeutic activities of essential oil (EO) isolated from Tagetes patula flowers. EO was extracted using the hydro-distillation (HD)

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Ogunmoyole, Temidayo, Oluwatobi Afolayan, Toluwalase Ajayi, and Omowunmi Jayeola Makun. "Ameliorative Potentials of Bambusa vulgaris Leaf Extract on Carbon tetrachloride Induced Toxicity in Albino Rats." Journal of Phytopharmacology 11, no. 4 (2022): 247–54. http://dx.doi.org/10.31254/phyto.2022.11404.

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Bambusa vulgaris has been widely utilized in folkloric medicine for the treatment several diseases. The present study evaluates the ameliorative effects of its leaves extract on carbon tetrachloride (CCl4) induced organs’ damage. This was done to provide a cost-effective and potent therapeutic option in the management of multi-organ disorders. Twenty Wistar rats were placed into five groups (I-V) of four animals each. All experimental animals, except group I were administered a single intraperitoneal dose of CCl4 (3 ml/kg b.w.). Animals in groups III and IV were treated with B. vulgaris at 200

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Ozsoy, Nurten, Alper Okyar, Pelin Arda-Pirincci, Ayse Can, Sehnaz Bolkent, and Nuriye Akev. "THE PROTECTIVE EFFECT OF AN AQUEOUS EXTRACT FROM SMILAX EXCELSA L. AGAINST CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS." African Journal of Traditional, Complementary and Alternative Medicines 13, no. 3 (2016): 203–8. http://dx.doi.org/10.21010/ajtcam.v13i3.24.

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Background: Because reactive oxygen species (ros) contribute to the pathogenesis of various acute and chronic liver diseases, dietary antioxidants and drugs from herbal origins have been proved to be beneficial as therapeutic agents in reversing hepatotoxicity and oxidative stress. The objective of this study was to investigate the protective effect of an aqueous extract from smilax excelsa l. Shoots and leaves against acute ccl4-induced liver injury as well as the changes in antioxidative defense system in female wistar albino rats. Materials and Methods: S. Exce

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Moharir, Gurudatta, Ambadasu Bharatha, Nkemcho Ojeh, and Vijay Prasad S. "Evaluation of Hepatoprotective effect of hydroalcoholic extract of Momordica Charantia leaves in carbon tetrachloride induced liver toxicity in Wistar rats." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1555–60. http://dx.doi.org/10.13005/bpj/1786.

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Liver carries out a variety of physiological functions and protects against damaging drugs and chemicals. Herbs have been shown to play a major role in the management of various liver disorders. Due to the lack of effective liver protective medication in modern medicine, several herbal options for the treatment of liver diseases in Ayurveda are suggested. In this current study, we evaluated the hepatoprotective action of Momordica charantia leaf extract in comparison to Liv-52, a standard hepatoprotective drug. In Wistar rats, hepatotoxicity was induced by administering carbon tetrachloride (C

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Koh, Pei Hoon, Ruzaidi Azli Mohd Mokhtar, and Mohammad Iqbal. "Andrographis paniculataameliorates carbon tetrachloride (CCl4)-dependent hepatic damage and toxicity: Diminution of oxidative stress." Redox Report 16, no. 3 (2011): 134–43. http://dx.doi.org/10.1179/1351000211y.0000000003.

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