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Masilionis, Tomas, Paulius Vargalis, and Raimondas Kiltinavičius. "VIRUSINĖS C HEPATITO INFEKCIJOS IR 2 TIPO CUKRINIO DIABETO KOMORBIDIŠKUMAS." Health Sciences 30, no. 5 (September 21, 2020): 14–17. http://dx.doi.org/10.35988/sm-hs.2020.106.
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C hepatitas yra virusinė infekcija, kuri sukelia kepenų pažeidimą. Šios ligos eiga pradžioje besimptomė, tad žmogus, nesijausdamas sergantis, gali ja užkrėsti kitus. Jei užsikrėtus šiuo virusu sergama besimptome ligos forma daugiau nei 6 mėnesius, ji dažniausiai pereina į lėtinę, kuri gali iš lėto progresuoti į kepenų cirozę ir sukelti hepatocitų karcinogenezę. Taip gali susiformuoti hepatoceliulinė karcinoma (HCC). Progresuodama C hepatito viruso (HCV) infekcija gali paveikti kitas gretutines ligas, ar netgi sukelti naujų. Viena iš tokių ligų yra 2 tipo cukrinis diabetas (CD2). Darbo tikslas – išsiaiškinti C hepatito viruso sukeltos infekcijos ir 2 tipo cukrinio diabeto sąsajas. Straipsnių paieška atlikta PubMed, BioMed Central duomenų bazėse. Naudotos raktažodžių kombinacijos: diabetes mellitus, hepatitis C virus extrahepatic manifestations. Rezultatai atskleidė, kad sergantiems HCV sukelta ciroze ir hepatoceliuline karcinoma, CD2 rizika didesnė. HCV labiau paplitęs tarp sergančiųjų CD2. Manoma, kad CD2 išsivystymas HCV sergantiems pacientams siejamas su β ląstelių disfunkcija arba autoimuniniu kasos pažeidimu. Rezistentiškumas insulinui skatina sergančiųjų HCV infekcija kepenų pažaidos bei HCC karcinomos vystymąsi, nepriklausomai, išsivystęs CD2 ar ne. Sergantiems cukriniu diabetu ir HCV turintiems pacientams ženkliai didėja HCC progresavimo rizika, kuri blogina gyvenimo kokybę. Svarbi kuo ankstyvesnė šių ligų diagnostika ir profilaktika, nutukimo, dislipidemijos korekcija bei alkoholio vartojimo ribojimas. Į prevencinius patikrinimus turėtų būti dažniau įtrauktas gliukozės kiekio matavimas kraujyje bei periodinis gliukozės tolerancijos mėginys. Tai sumažintų ne tik CD2, bet ir HCC išsivystymo riziką. Nustatyta, kad sėkmingas HCV gydymas gali sumažinti susirgimo cukriniu diabetu riziką. Ilgą laiką sėkmingai gydant interferonu ar tiesiogiai veikiančiais priešvirusiniais preparatais, pastebėta CD2 regresija. Lyginant HCV gydymą interferonais ir tiesiogiai veikiančiais priešvirusiniais preparatais, geresnė CD2 kontrolė gauta, kuomet pacientai buvo gydomi tiesiogiai veikiančiais priešvirusiniais preparatais.
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Norkienė, Sigutė, Jonas Sąlyga, Vida Jankauskienė, and Eglė Dimaitė. "HEMODIALIZĖS SKYRIUJE DIRBANČIŲ MEDICINOS DARBUOTOJŲ RIZIKOS VEIKSNIŲ IR JŲ ĮTAKOS SVEIKATAI ANALIZĖ." Sveikatos mokslai 24, no. 4 (February 20, 2014): 106–10. http://dx.doi.org/10.5200/sm-hs.2014.076.
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2008 m. spalio mėn. – 2009 m. vasario mėn. ano- niminiu anketiniu būdu buvo apklausti Žemaitijos krašto (Klaipėdos, Telšių, Šiaulių apskričių) hemo- dializės skyrių 173 medicinos darbuotojai: 17 gydy- tojų, 115 bendrosios praktikos slaugytojų ir 41 slau- gytojos padėjėja. Statistinė duomenų analizė atlikta SPSS programa (11.5 versija). Tyrimo metu nustatyta, jog 5,9 proc. gydytojų, 10,4 proc. slaugytojų ir 12,2 proc. padėjėjų diagnozuo- tas hepatitas B bei 1,7 proc. slaugytojų – hepatitas C. Nustatyta statistiškai reikšminga priklausomy- bė tarp užsikrėtimo hepatito B virusu ir darbo pa- tirties bei pirštinių mūvėjimo invazinių procedūrų metu. Hemodializės skyrių medikams stresą sukelia šie veiksniai: susidūrimas su mirtimi (81,5 proc.), paciento kančia (63,6 proc.). Slaugos specialistams vienas iš stresą sukeliančių veiksnių - mažas atly- ginimas. Po patirto streso medikai skundžiasi sti- priu ar dažnu širdies plakimu (32,9 proc.), stipriu prakaitavimu (35,8 proc.), galvos skausmais (26,6 proc.), apetito praradimu (21,4 proc.). Dezinfeka- vimo metu gumines latekso pirštines naudoja 92,2 proc. slaugytojų ir 87,8 proc. padėjėjų, veido kau- kes – 50,4 proc. slaugytojų ir 17,1 proc. padėjėjų, respiratorius – 0,9 proc. slaugytojų ir 2,4 proc. padė- jėjų. Dezinfekcijos metu statistiškai patikimai daž- niau slaugytojos naudoja veido kaukes nei padėjė- jos. Slaugos specialistams buvo nustatyti odos pa- raudimo ir perštėjimo (70,5 proc.), galvos skausmo (54,5 proc.), galvos svaigimo (52,6proc.), bendro silpnumo (48,7 proc.), alerginio rinito (39,1proc.), kosulio (26,3 proc.), alerginio konjunktyvito (25,0 proc.) simptomai.
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Viana, Daniel Rodrigues, Nathalia Mundoco Veloso, Osvaldo Carvalho Neto, Nicolas Garcia Papacosta, Gabriel Martins Nunes, and Virgílio Ribeiro Guedes. "Hepatite B e C: diagnóstico e tratamento." Revista de Patologia do Tocantins 4, no. 3 (September 26, 2017): 73. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n3p73.
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INTRODUÇÃO: As hepatites virais são consideradas as principais doenças hepáticas, podendo levar a quadros mais graves, como a cirrose e o carcinoma hepatocelular, tornando-se um importante problema de saúde pública. Tem distribuição global com áreas de altos índices de endemicidade, sobretudo em países asiáticos. Os principais agentes envolvidos são os vírus da hepatite A, B, C, D, E. O vírus da hepatite B e C se destacam nesse meio devido à grande capacidade de cronificação. As formas de transmissão são basicamente através do contato com fluidos corporais infectados, através de transfusões sanguíneas, uso de drogas injetáveis, transmissão vertical, etc. METODOLOGIA: Trata-se de um artigo de revisão no qual, a partir das palavras “hepatite B” e “hepatite C”, foi realizado busca por periódicos nos bancos de dados: PubMed, Scielo, Portal Periódicos CAPES e Google acadêmico. CONCLUSÃO: As hepatites B e C podem se apresentar apenas de forma aguda, ou podem se cronificar. O diagnóstico geralmente é realizado tardiamente, pois, na grande maioria dos casos apresenta-se oligossintomáticas ou até mesmo assintomática. O diagnóstico é feito através de exames sorológicos e quantificação viral através do PCR. O tratamento é basicamente sintomático, porem nos casos crônicos, é indicado uso de medicações, como interferons peguilhados e análogos de nucleosideos.
Palavras-chave: Hepatites virais; Hepatite B; Hepatite C.
INTRODUCTION: Viral hepatitis are considered as one of the major liver diseases, being able to lead more severe outcomes, such as cirrhosis and hepatocellular carcinoma becoming an important public health problem. It has global distribution with areas of high endemicity, especially in Asian countries. The main agents involved are hepatitis A virus, B, C, D, E. The hepatitis B and C viruses stand out in the middle of a chronicling ability. As the transmission forms are basically through contact with infected body fluids, through blood transfusions, injecting drug use, vertical transmission, etc. METHODOLOGY: This is a review article, from the words "hepatitis B" and "Hepatitis C", was carried out by search for journals in databases: PubMed, Scielo, Portal Periodicos CAPES and Google academic. CONCLUSION: The hepatitis B and C can either be only a form of acute, or can be chronic. Therefore, the diagnosis is often late, since in the vast majority of cases it is oligosymptomatic or even asymptomatic. The diagnosis is made through serological tests and viral quantification through PCR. The treatment is basically with symptomatic, such as pegged interferon’s and nucleoside analogs.
Keywords: Viral hepatitis; Hepatitis B; Hepatitis C.
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Salam, Abdul, Bilqis Aslam Baloch, Naseer Khan, Ghulam Sarwar, and Masoom ,. "SEROPREVALENCE OF HBsAg (HBS) AND ANTI-HCV." Professional Medical Journal 21, no. 04 (December 7, 2018): 766–70. http://dx.doi.org/10.29309/tpmj/2014.21.04.2424.
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Background: Hepatitis is the inflammation of liver caused by infectious and noninfectiousagents. Hepatitis B and C are inflammations of liver caused by the viruses which are themajor public health problems worldwide and the incidence is even more in our country.Objective: Objective of the study was, 1). To estimate the prevalence of hepatitis B and hepatitisC viruses infected persons among the general population coming to BMC Hospital. 2). To pointout the more affected area of Baluchistan. 3). To produce awareness in the people. 4). To bringthis issue in Government notice. Method: The data was obtained from the patients of BMCHQuetta in which one step test kits were used first and the positive cases were confirmed by ELISA.Results: Out of 46319 samples tested (both indoor & outdoor patients), 3078 (6.64%) werepositive. From overall positive samples 1631(3.52%) were HBs positive and 1447(3.12) sampleswere positive for HCV and 2 patients were positive for both HBs Ag and anti HCV. Conclusions:Prevalence of Hepatitis B is more comparing to Hepatitis C in this province. Prevalence of bothHepatitis B and Hepatitis C was high in Naseerabad district of Baluchistan Great care should beexercised during shaving, dental treatment, surgical procedures and blood transfusions. Policymessage: - Media should be used by National Hepatitis Control Programme of Pakistan toeducate the public about hazards of unscreened blood transfusion. Blood screening for HepatitisB and C infections should be made mandatory at all blood banks.
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Leite, Juliana Mayara da Silva, Jéssica de Oliveira Inácio, Raissa Silva De Melo Monteiro, Cristiane da Câmara Marques, Vanessa Pinheiro Barreto, and Alexsandra Rodrigues Feijão. "Sociodemographic and clinical characterization of patients with chronic hepatitis C." Enfermería Global 18, no. 3 (June 6, 2019): 157–94. http://dx.doi.org/10.6018/eglobal.18.3.316971.
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Objetivo: Describir la caracterización sociodemográfica y clínica de los pacientes portadores de hepatitis C crónica acompañados en el ambulatorio de un hospital de referencia en infectología. Método: Estudio transversal, descriptivo, cuantitativo, con usuarios portadores de hepatitis C crónica asistidos en el ambulatorio de un hospital de referencia durante noviembre de 2015 a abril de 2016 con una muestra de 47 usuarios. Resultados: Los participantes son de sexo masculino (76,6%) con rango de edad superior a 57 años (57,5%), pardo (38,3%), casado (55,3%), con grado de escolaridad (31,9%), y residente en la capital (61,7%), con tiempo de descubrimiento de hasta 6 años (68,1%), desconociendo la forma de contaminación (57,5%), inmunizado contra la hepatitis B (65,9%), realizando tratamiento medicamentoso (85,1%) con Ribavirina (55,6%); Y el 70,2% presentó efectos adversos. Conclusión: La caracterización sociodemográfica y clínica auxilian en la práctica clínica del equipo multiprofesional con los portadores de hepatitis C crónica. Objective: To describe the sociodemographic and clinical characterization of patients with chronic hepatitis C followed at the outpatient clinic of a reference hospital in infectology.Method: A cross-sectional, descriptive, quantitative study with chronic hepatitis C patients attended at a referral hospital during November 2015 to April 2016 with a sample of 47 users. Results: The participants were male (76.6%), 57 years old (57.5%), brown (38.3%), married (55.3%), (61.7%), with a discovery time of up to 6 years (68.1%), not knowing the form of contamination (57.5%), immunized against hepatitis B (65.9%), undergoing drug therapy (85.1%) with Ribavirin (55.6%); And 70.2% had adverse effects. Conclusion: Sociodemographic and clinical characterization assist the clinical practice of the multiprofessional team with patients with chronic hepatitis C Objetivo: Descrever a caracterização sociodemográfica e clínica dos pacientes portadores de hepatite C crônica acompanhados no ambulatório de um hospital referência em infectologia. Método: Estudo transversal, descritivo, quantitativo, com usuários portadores de hepatite C crônica assistidos no ambulatório de um hospital referência durante Novembro 2015 a Abril de 2016 com uma amostra de 47 usuários. Resultados: Os participantes encontram-se no sexo masculino (76,6%) com faixa etária acima de 57 anos (57,5%), pardo (38,3%), casado (55,3%), com grau de escolaridade fundamental incompleto (31,9%), e residente na capital (61,7%), com tempo de descoberta de até 6 anos (68,1%), desconhecendo a forma de contaminação (57,5%), realizando tratamento medicamentoso (85,1%) com Ribavirina (55,6%); e 70,2% apresentaram efeitos adversos. Conclusões: A caracterização sociodemográfica e clínica auxiliam na prática clínica da equipe multiprofissional com os portadores de hepatite C crônica.
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Jain, Ravi, and Ashok Yadav. "Hepatitis B Versus Hepatitis C in Blood Donors." Annals of Applied Bio-Sciences 4, no. 1 (January 2017): A8—A13. http://dx.doi.org/10.21276/aabs.2017.1306.
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Maria, Rafael Carvalho de, Joseneide Teixeira Câmara, Maria Edileuza Soares Moura, Felipe Santana e. Silva, and Josemeire da Costa Ximenes. "Analysis of space and epidemiological distribution of hepatitis b and c cases in municipaly maranhão / Análise da distribuição espacial e epidemiológica dos casos de hepatite b e c em município maranhense." Revista de Pesquisa Cuidado é Fundamental Online 13 (September 22, 2021): 1421–27. http://dx.doi.org/10.9789/2175-5361.rpcfo.v13.9702.
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Objetivo: analisar a distribuição espacial e epidemiológica dos casos notificados de hepatite B e C, de 2012 a 2016 no município de Caxias, Maranhão. Métodos: estudo transversal, retrospectivo, descritivo e analítico, aplicando-se técnicas de geoprocessamento da região. Utilizaram-se dados secundários das fichas de notificação de hepatites virais com sorologia positiva para Hepatite B, Hepatite C e Hepatite B/Hepatite C. Resultados: pessoas da raça/cor parda, entre 15 a 29 anos, não vacinados, as gestantes e os submetidos a tratamentos invasivos tem maiores chances de apresentar marcadores sorológicos positivos para hepatites. A análise espacial evidenciou que a região norte concentra o maior número de casos. Conclusão: a região norte por ser classificada como área de baixa infraestrutura e relativamente mais pobre que as outras favorece o estabelecimento dessas doenças na população. A análise espacial pode auxiliar os serviços no planejamento consistente para o controle e prevenção das hepatites.
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Leite Segundo, Airton, Emerson Filipe Nogueira, Patrícia Élida Carvalho, and Maria Sueli Soares. "Avaliação da soroprevalência dos vírus das hepatites B e C em cirurgiões-dentistas." Journal of the Brazilian College of Oral and Maxillofacial Surgery 5, no. 3 (November 20, 2019): 29–33. http://dx.doi.org/10.14436/2358-2782.5.3.029-033.oar.
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Objetivo: o presente estudo objetivou determinar a soroprevalência das hepatites B e C em cirurgiões-dentistas na cidade de Caruaru (Pernambuco, Brasil). Métodos: a amostra foi composta por 80 profissionais que foram submetidos à coleta de sangue para realização de exames sorológicos (HBsAg e anti-VHC) para as hepatites B e C, como também foi realizada entrevista, abordando o tempo de formado, histórico de acidentes com material perfurocortante, e vacinação contra hepatite B. Os dados obtidos foram processados no programa Microsoft EXCEL® e realizada análise descritiva. Resultados: com relação à soroprevalência, foram confirmados dois casos de hepatite B e um caso de hepatite C, representando prevalência de 2,5% e 1,25%, respectivamente. A média de tempo de formado foi de 17,35 anos. Cinquenta e dois por cento dos profissionais relataram acidente com material perfurocortante. Os resultados revelaram que 75% dos entrevistados apresentaram a vacinação completa contra a hepatite B. Conclusão: conclui-se que os cirurgiões-dentistas da cidade de Caruaru apresentaram baixa prevalência de infecção pelos vírus das hepatites B e C e que 1⁄4 dos profissionais não apresentaram vacinação contra hepatite B regular. Palavras-chave: Hepatite. Vírus da hepatite. Odontólogos. Riscos ocupacionais.
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CONTE, Vinício Paride. "Hepatite crônica por vírus C: Parte 1. Considerações gerais." Arquivos de Gastroenterologia 37, no. 3 (July 2000): 187–93. http://dx.doi.org/10.1590/s0004-28032000000300010.
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O vírus da hepatite C foi identificado em 1989 como sendo o principal agente causador das hepatites não-A não-B e o seu reconhecimento como agente de alta prevalência nas infecções pós-tranfusionais e/ou uso de derivados do sangue ou em associação com o abuso de drogas endovenosas. A descoberta e a maior disponibilidade de novas técnicas para a seleção adequada de doadores de sangue, reduziu sensivelmente a incidência das hepatites pós-transfusionais. Cerca de 95% dos indivíduos infectados pelo vírus da hepatite C podem ser identificados pelos testes anti-vírus da hepatite C de terceira geração. Os estudos retrospectivos de infecções pelo vírus da hepatite C iatrogênicas, são as principais fontes de reconhecimento da história natural da doença. A distribuição dos diferentes genótipos do vírus da hepatite C varia de acordo com as regiões geográficas. Na América do Sul, Europa, Estados Unidos e Japão 1, 2, e 3 representam a maioria das infecções, sendo o subtipo 1-b o mais prevalente. Os parâmetros epidemiológicos (idade, fatores de risco e duração da infecção) podem estar associados com os genótipos do vírus da hepatite C, sendo os tipos 1-a e 3-a mais freqüentes nos drogaditos endovenosos e o 1-b nas hepatites pós-transfusionais. O subtipo 1-b ocasiona lesões hepáticas mais graves e prolongadas, com alterações ultraestruturais mitocondriais freqüentes e grande comprometimento dos processos de fosforilização oxidativa. A produção aumentada de radicais livres pode influenciar negativamente a evolução da doença hepática pelo reforço da ação citopática do vírus da hepatite C que provoca. O significado clínico dos níveis de vírus C no interior do fígado, nesses pacientes, não é determinado pelos fatores hospedeiro (idade, tipo e duração da infecção) ou pelos fatores virais (genótipos) e os repetidamente vírus da hepatite C RNA RT-PCR negativos no soro, não indicam necessariamente ausência de vírus da hepatite C no fígado. A associação de autoimunidade à hepatite C é questionável. Os marcadores imunes são freqüentemente detectados em baixos níveis. A modulação da resposta imune ao envelope protéico E2, após injeção de plasmídios DNA, tem sido usada para induzir respostas imunes específicas ao vírus da hepatite C. O espectro de tais respostas poderia ser ampliada mediante combinação de plasmídios, vias de administração e outras formas de imunógenos codificados (vacinas a base de peptídios). Tais estratégias podem vir a ser importantes, em breve, no combate aos altamente mutantes vírus da hepatite C. O papel patogênico dos novos vírus G e TT das hepatites está em estudos, porém é de consenso que suas associações com doença hepática ativa é fortuita.
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Payne, E., S. Totten, and C. Archibald. "Surveillance de l'hépatite C au Canada." Relevé des maladies transmissibles au Canada 40, no. 19 (December 18, 2014): 433–41. http://dx.doi.org/10.14745/ccdr.v40i19a01f.
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Cruz, Camila Rodrigues Bressane, Miriam Matsura Shirassu, and Wellington P. Martins. "Comparação do perfil epidemiológico das hepatites B e C em um serviço público de São Paulo." Arquivos de Gastroenterologia 46, no. 3 (September 2009): 225–29. http://dx.doi.org/10.1590/s0004-28032009000300016.
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CONTEXTO: As hepatites virais constituem doença de notificação compulsória e apresentam grande importância em nosso meio devido à elevada prevalência. OBJETIVO: Comparar o perfil epidemiológico dos casos confirmados de hepatites B e C notificados no Núcleo de Vigilância Epidemiológica do Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, no período entre janeiro de 2004 e abril de 2007. MATERIAL: Os resultados foram analisados através do teste do qui ao quadrado. RESULTADOS: Observou-se 112 casos confirmados de hepatite B e 651 de hepatite C. Houve predominância do sexo masculino dentre os casos de hepatite B e do sexo feminino entre os de hepatite C, com significância estatística. A faixa etária mais frequente foi de 30 a 39 anos, considerando-se hepatite B (P<0,01) e 40 a 49 anos para hepatite C (P = 0,49). A astenia foi o sintoma mais relatado. Os fatores de risco predominantes foram: doenças sexualmente transmissíveis (hepatite B; P<0,01), tratamento cirúrgico e transfusão de sangue (hepatite C; P<0,01). A confirmação por critério laboratorial foi predominante e quanto à forma clínica, observou-se evolução para hepatite crônica em 54,5% e 81,7% dos casos, respectivamente para hepatite B e C (P<0,01). A transmissão do vírus B ocorreu predominantemente por via sexual (P<0,01), enquanto o vírus C foi predominantemente transmitido por transfusão (P<0,01). CONCLUSÕES: Os dados referentes ao perfil epidemiológico dos pacientes foram semelhantes aos disponíveis na literatura nacional e internacional. Ressalta-se a importância da vigilância epidemiológica na determinação do perfil das hepatites virais, permitindo que se estabeleçam propostas adequadas de prevenção e rastreamento.
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Jamali, Ghulam Mustafa, Anwar Ali Jamali, and Habibullah Shaikh. "HEPATITIS C VIRUS;." Professional Medical Journal 24, no. 11 (November 3, 2017): 1621–29. http://dx.doi.org/10.29309/tpmj/2017.24.11.646.
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Objectives: The plan of this current research was in the direction for towards theassessment of the existing ELISA (Enzyme Linked Immunosorbant Assay) method throughantibodies testing for identification of hepatitis C virus disease by comparing their outcome withthe Real Time polymerase chain reaction analysis. Setting: Peoples Medical College HospitalNawabshah. Period: December 2015 to December 2016. Methods: In this current research 100blood samples were analyzed due to the presence of anti-HCV antibodies by 3rd-generationenzyme-linked immunosorbent assay testing. All the specimens were 100% positive. Polymerasechain reaction test was performed according to the laboratory directions in anti- hepatitis C virusantibodies positive patients to validate the diagnosis of hepatitis C virus infectivity. Results: Thisresearch shows that, the entire results were positive by Enzyme Linked Immunosorbant Assaytesting. As compared with polymerase chain reaction the of Enzyme Linked ImmunosorbantAssay in this research the screening test for anti hepatitis C virus - antibodies is about 2%false positive. Out of the 100 samples 98 cases are positive by Real Time polymerase chainreaction analysis while only 02 cases report are negative (2%). Conclusion: The proportion ofhepatitis C virus infectivity was 100% by 3rd-generation enzyme-linked immunosorbent assaytesting, 98% by Real Time polymerase chain reaction analysis. As in our research the hepatitisC virus –Ribonucleic acid is present in 98% cases who are the Anti- hepatitis C virus antibodiespositive patients, it can be suggested that Anti-HCV antibodies detection by third generationELISA technique in routine procedure is sufficient to determine HCV infection.
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Lovena, Angela, Saptino Miro, and Efrida Efrida. "Karakteristik Pasien Sirosis Hepatis di RSUP Dr. M. Djamil Padang." Jurnal Kesehatan Andalas 6, no. 1 (July 20, 2017): 5. http://dx.doi.org/10.25077/jka.v6i1.636.
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Sirosis hepatis didefinisikan sebagai penyakit hati kronik yang menyebabkan proses difus pembentukan nodul dan fibrosis pada hati. Di RSUP Dr. M. Djamil Padang sirosis hepatis merupakan salah satu penyakit terbanyak yang dirawat di Bagian Penyakit Dalam. Tujuan penelitian ini adalah menentukan karakteristik pasien sirosis hepatis di RSUP Dr. M. Djamil Padang. Penelitian ini merupakan studi deskriptif observasional dengan menggunakan data rekam medik pasien sirosis hepatis yang dirawat di ruang rawat inap Bagian Ilmu Penyakit Dalam RSUP Dr. M. Djamil Padang periode 1 Januari 2011 sampai 31 Desember 2013, sehingga didapatkan sampel penelitian sebanyak 304 buah. Data yang diambil yaitu tes serologi untuk hepatitis B dan hepatitis C, kadar albumin, jumlah trombosit, kadar kreatinin serum dan komplikasi sirosis hepatis. Hasil penelitian ini mendapatkan penyebab sirosis hepatis terbanyak virus hepatitis B (51,0%), kadar albumin <3,0 g/dl (71,4%), jumlah trombosit normal (48,7%), kadar kreatinin normal (76,7%), komplikasi terbanyak asites (36,3%),dan klasifikasi Child pugh terbanyak adalah Clid pugh C (60,3%). Simpulan penelitian ini adalah hepatitis B sebagai penyebab tersering, kadar albumin terbanyak adalah <3,0 g/dl, jumlah trombosit terbanyak adalah jumlah trombosit dan kadar kreatinin terbanyak adalah yang normal, asites sebagai komplikasi terbanyak dan klasifikasi terbanyak adalah Child pugh C.
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Nouman, Muhammad Khuram, Bushra Zaidi, Ghulam Mohiuddin, Faryal Asif, and Muhammad Khan Malik. "HEPATITIS C." Professional Medical Journal 25, no. 03 (March 10, 2018): 387–91. http://dx.doi.org/10.29309/tpmj/2018.25.03.381.
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Background: Hepatitis C virus (HCV) is the most communal source of non-A,non-B viral hepatitis in the world. The disease is illusory, and the majority of patients do notacquire jaundice at its onset. Treatment of hepatitis C with interferon attained a sustainedvirological response (SVR) in almost 50% of the patients with HCV infection. Viral genotype isimportant to determine the response. The present study aims to provide the incidence of relapseof HCV in patients taking interferon therapy and to identify the predictors for relapse. StudyDesign: Retrospective observational study. Setting: Department of Medicine, DHQ TeachingHospital, Sargodha. Period: Two years. Methods: A total of 60 patients were retrospectivelyevaluated for this study. The exclusion criteria include the patients co- infected with hepatitisB virus or HIV. All the patients were monitored 2, 4, 8, 12, 16, and 24 weeks after the endof treatment with interferon alpha. Results: We observed that the patients with relapse weresignificantly older and heavier (P value < 0.05). At the start of treatment, viral load was higherin relapsed patients (P value < 0.04). Conclusion: On the bases of our study findings, we canconclude that low incidence of relapse occurred with interferon therapy. High ALT level, viralloads, older age and obesity were some of strong predictors of relapse among HCV patients.
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Atmane, Seba. "Viral Hepatitis C (HCV) in Hemodialysis." Journal of Clinical Case Reports and Studies 1, no. 2 (July 2, 2020): 01–05. http://dx.doi.org/10.31579/2690-8808/009.
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The aim of the study is to show the prevalence and risk factors of HCV at our hemodialysis (HD) center , in a study carried out on chronic hemodialysis patients during the year 2019, we identified eight cases out of 87 patients infected with HCV, or 9%. The average age in this population is 48 years, dialysed for an average of 15 years. Viral infection was discovered on average 12.5 years after the start of hemodialysis, during a routine screening examination. In this series, the genotype 1b was found in 2 cases (25%). Seven patients were treated out of the eight HCV hemodialysis patients, received dual therapy with sofosbuvir 400mg and daclar 60 mg for three months, with an early virologic response. A study done during a previous period, between 2015 and 2018, in the same center, looking at the risk factors for HCV transmission: 11 cases out of 134 hemodialysis patients infected with HCV. Among these cases, we noted the following factors; Blood transfusion: 3 cases (27.2%), surgery: 4 cases (45.4%), dental care: 2 cases (18%), no obvious cause: 2 cases (9%). Serologically ; HCV antibodies positive: 11/134, i.e. an 8.2% seroprevalence, PCR-viral RNA was positive in 10 out of 11 patients, i.e. a prevalence of 7.4% by PCR, number of copies: Above 1.03x 1, 000,000 (100%), number of Logs: Sup to 3.32 (100%), negative PCR: 01 patient.
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BURUK, Celal Kurtuluş, Gülçin BAYRAMOĞLU, Ahu REİS, Neşe KAKLIKKAYA, İlknur TOSUN, and Faruk AYDIN. "Determination of Hepatitis C Virus Genotypes Among Hepatitis C Patients in Eastern Black Sea Region, Turkey." Mikrobiyoloji Bulteni 47, no. 4 (October 30, 2013): 650–57. http://dx.doi.org/10.5578/mb.5796.
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Teplyuk, N. P., Ekaterina Yu Vertieva, D. V. Ignatyev, and I. S. Dzhavakhishvili. "Porphyria cutanea tarda concomitant with chronic hepatitis C." Russian Journal of Skin and Venereal Diseases 19, no. 1 (February 15, 2016): 17–20. http://dx.doi.org/10.18821/1560-9588-2016-19-1-17-20.
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Porphyrias form a group of rare metabolic diseases associated with disorders in the heme biosynthesis enzymes, leading to porphyrin accumulation in tissues. The disease is rare and is often diagnosed too late. The most incident is porphyria cutanea tarda. All patients with this condition should be tested for viral hepatites and hemochromatosis. A clinical case is presented: a patient with porphyria cutanea tarda associated with alcohol abuse and viral hepatitis C.
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Billah, Mustansar, Syed Muhammad Raza Shah, and Muhammad Mujtaba Hashir. "HEPATITIS B AND HEPATITIS C." Professional Medical Journal 25, no. 08 (August 9, 2018): 1245–51. http://dx.doi.org/10.29309/tpmj/18.4766.
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Isabelle Nogueira de Araújo, Anne, Jéssica Mayara de Figueirêdo Oséas, Júlio César Brigolini de Faria, Beatriz De Pedro Netto Mendonça, Camila Moreira Lima, Fabíola Pessôa Pereira Leite, and Laércio Almeida de Melo. "PERFIL EPIDEMIOLÓGICO DAS HEPATITES B E C NO ESTADO DO RIO GRANDE DO NORTE." Revista Ciência Plural 6, no. 3 (September 23, 2020): 35–52. http://dx.doi.org/10.21680/2446-7286.2020v6n3id20537.
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Introdução: Considerado um grave problema de saúde pública, a Hepatite é uma doença que se destaca por ser silenciosa e nem sempre apresentar sinais e sintomas, favorecendo assim o atraso no seu diagnóstico. Objetivo: Diante de um crescimento contínuo no estado do Rio Grande do Norte (RN) de casos de Hepatite B e C, o presente trabalho objetivou identificar o perfil epidemiológico da população do RN diagnosticada e notificada com hepatites B e/ou C entre os anos de 2007 a 2015, segundo as regionais de saúde. Método: Trata-se de um estudo observacional, descritivo, do tipo transversal, que utilizou uma consulta ao DATASUS para a obtenção dos dados. Resultados: Verificou-se que houve predominância do sexo masculino dentre os casos de hepatite B e C, assim como a faixa etária de 20 a 39 anos, considerando-se hepatite B e 40 a 59 para a hepatite C. Ademais, a raça parda foi a predominante em ambos os tipos virais; a 7ª região de saúde foi a regional que mais possuiu notificação e houve uma maior prevalência dos casos de hepatite B e C em pessoas com menores níveis de escolaridade. Conclusões: Concluiu-se que o perfil das hepatites B e C no estado do Rio Grande do Norte tem se mostrado semelhante aos dados do Brasil, com uma alta prevalência, sugerindo assim a necessidade de se ter uma maior articulação entre os setores e departamentos responsáveis pelo registro e controle das hepatites virais do tipo B e C e a importância do gestor em saúde frente a essas situações para a realização de medidas preventivas.
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Lico da Silva, Davi, Diego Ludvig Kieling, Thais Thronicke Ribeiro Maran, Eduardo Miguel Prata Madureira, and Rubens Griep. "INDICADORES E DADOS BÁSICOS DA HEPATITE C NOS MUNICÍPIOS VINCULADOS A 10ª REGIONAL DE SAÚDE E SUA COMPARAÇÃO COM O ESTADO DO PARANÁ E BRASIL." FAG JOURNAL OF HEALTH (FJH) 2, no. 4 (December 20, 2020): 440–44. http://dx.doi.org/10.35984/fjh.v2i4.274.
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Hepatites virais são doenças que acometem a população global tornando-se um problema de saúde pública. Atualmente houve avanço no tratamento e prevenção das hepatites virais com campanhas de vacinação contra a hepatite do tipo B, hábitos de higiene, saneamento básico e novas tecnologias de rastreio molecular do vírus da hepatite C. O objetivo da pesquisa foi identificar os indicadores e dados básicos da hepatite C em 25 municípios da 10ª Regional de Saúde, em Cascavel, e compará-los com os dados do Paraná e Brasil que teve mais de 228 mil casos com hepatite C e 28.823 óbitos causados pela doença. No estado do Paraná, foi marcante a divergência dos dados, já que em uma tabela observamos 19.179 paciente diagnosticados e na outra 11.432 e houve 1.232 óbitos. Na Regional, Cascavel destacou-se com mais casos de hepatite C, sendo 914 e 17 óbitos, depois Corbélia com 20 casos, e Jesuítas, com 16. Já os óbitos seguem-se com Formosa do Oeste 2, Capitão Leônidas Marques, Jesuítas, Nova Aurora e Três Barras do Paraná, uma morte cada. Deste modo, conclui-se que a importância da vigilância epidemiológica da hepatite C é fundamental no rastreio do tratamento e prevenção da doença.
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Gusmão, Kamile Eller, Fellipe Camargo Ferreira Dias, Victor Mateus Xavier De Santana, Enoque Júnio da Rocha Calado, Vitória De Souza Oliveira, Amanda Amâncio Oliveira, Pedro Henrique Procópio Lobo, Aline Almeida Liberato, Aline Barbosa Lopes, and Virgílio Ribeiro Guedes. "PERFIL CLÍNICO-EPIDEMIOLÓGICO DA HEPATITE C NA REGIÃO NORTE DO BRASIL ENTRE 2012 E 2015." Revista de Patologia do Tocantins 4, no. 2 (June 20, 2017): 41. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n2p41.
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A hepatite C é uma doença viral, infecciosa e contagiosa, que representa grave problema de saúde pública de distribuição mundial. O objetivo foi aracterizar o perfil epidemiológico desta afecção na região Norte no período de 2012 a 2015, correlacionando-o com dados nacionais e mundiais. Foi realizado um estudo descritivo, retrospectivo, clínico e epidemiológico dos casos notificados de hepatite do tipo C na região Norte do Brasil, no período de 2012 a 2015 tendo como base o banco de dados oficial do Sistema de Informação de Agravos de Notificação – SINAN. No período estudado observou-se uma incidência regional e nacional decrescente da infecção por hepatite C, tendo como maiores os valores encontrados no ano de 2012, com o registro de 607 doentes novos na região Norte e 16523 no Brasil. Foram notificados 3083 casos entre 2012 e 2015 na região Norte, com uma média de 770,75 casos, sendo o diagnóstico realizado entre 40 e 59 anos em mais de 50% dos casos. A distribuição da doença é essencialmente urbana, com 2736 casos novos (88,7% do total), equilibrada entre os sexos (1,12 homem para cada mulher) e mais incidente na raça parda, com 2483 registros (mais de 80% da totalidade). A hepatite C é a terceira hepatite infecciosa mais incidente, correspondendo a 14% dos casos novos e sua identificação foi feita na forma crônica em 91% das vezes. A hepatite pelo vírus C é uma doença de distribuição mundial, mesmo em países de alto índice de desenvolvimento humano, com elevados níveis de cronicidade e morbidade e prevenível através de medidas de educação em saúde e segurança no trabalho. Palavras-chave: Hepatite C, Epidemiologia, região Norte, Brasil.
ABSTRACT
Hepatitis C is a viral, infectious and contagious disease that represents a serious public health problem of worldwide distribution. To characterize the epidemiological profile of this condition in the North region in the period from 2012 to 2015, correlating it with national and global data. A descriptive, retrospective, clinical and epidemiological study of the reported cases of type C hepatitis in the North region of Brazil was accomplished during the period from 2012 to 2015, based on the official database from the National Notification Disease Information System – SINAN. A decreasing regional and national incidence of hepatitis C infection was observed during the studied period, with the highest values found in 2012, with 607 new patients in the North region and 16523 in Brazil. A total of 3083 cases were reported between 2012 and 2015 in the North region, with an average of 770.75, and the diagnosis being made between 40 and 59 years in more than 50% of the cases. The distribution of the disease is essentially urban, with 2736 new cases (88.7% of the total), proportional between the sexes (1.12 man for each woman) and more incident in the brown race, with 2483 records (more than 80% of the totality). Hepatitis C is the third most frequent infectious hepatitis, accounting for 14% of new cases and was identified in its chronic form 91% of the time. C virus Hepatitis is a disease of worldwide distribution, even in countries with a high human development index, with high levels of chronicity and morbidity and preventable through health education and safety at work.Keywords: Hepatitis C, Epidemiology, North, Brazil.
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Mohammad, Mohammad O. "Prevalence of Hepatitis-B and Hepatitis-C among Blood Donors in Sulaimani City." Journal of Zankoy Sulaimani - Part A 9, no. 1 (September 23, 2005): 115–24. http://dx.doi.org/10.17656/jzs.10155.
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Gülseren, Yasemin Derya, Fatma Esenkaya Taşbent, Mehmet Özdemir, and Bahadır Feyzioğlu. "Hepatitis C Genotypes in Patients with Chronic Hepatitis C Infection: A Three-Year Evaluation." Flora the Journal of Infectious Diseases and Clinical Microbiology 25, no. 3 (September 15, 2020): 347–53. http://dx.doi.org/10.5578/flora.69063.
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Introduction: In case of chronic hepatitis C infection, cirrhosis and hepatocellular carcinoma may progress. HCV genotypes and subtypes have been found to vary according to geographical regions. In addition to its epidemiological importance, HCV genotype is an important factor in determining the response and duration of treatment. In this study, it was aimed to determine the genotype distribution in our region. Materials and Methods: The results of 241 patients with HCV RNA positivity detected in our laboratory Molecular unit between 2016 and 2018 were retrospectively screened. HCV-RNA extraction for genotyping was performed by automated system (EZ1 Virus Mini Kit v.2.0, Germany), and ‘’line probe assay’’ (LIPA) based on reverse hybridization method was applied. HCV-RNA levels were determined by real-time PCR method (Artus HCV QS-RGQ kit, Qiagen, Germany). Results: Two hundred and forty-one patients were included in the study, and 116 (48%) were females and 125 (52%) were males. Mean age was 56.1 ± 19.4 (range: 16-90) years. Mean logarithmic viral load value was 5.7 ± 0.9 IU/ml (range; 2.71 x 102-17 x 106), mean value of AST was 50.5 ± 43.7 IU/ml and mean ALT value was 63.4 ± 63.5 IU/ml. Genotype 1b was detected in 58.9% of the patients, genotype 3a in 14.1%, genotype 1a in 13.27%, genotype 2b in 4.1%, genotype 4a in 1.2%. The subtypes could not be determined for 4.9%, 1.2%, 1.6% and 0.4% of infected patient in genotype 1,2,4 and 5 respectively. Conclusion: In our study, genotype 1b (58.9%) was found as the dominant genotype. This was followed by genotype 3a (14.1%). In patients infected with genotype 1, viral load value was found to be significantly higher than other genotypes. Monitoring genotype change is important for determining treatment protocols and duration.
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Kara, İsmail Hamdi. "Acute viral hepatitis C." Turkiye Aile Hekimligi Dergisi 12, no. 2 (2008): 89–94. http://dx.doi.org/10.2399/tahd.08.089.
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Cibelle Nunes Silva, Ravena, Edilson Martins Rodrigues Neto, Lidia Audrey Rocha Valadas Marques, Mara Assef Leitão Lotif, Érika Saboia Guerra Diógenes, and Renata De Sousa Alves. "Abuso de Drogas: Relação entre Hepatite C e CO- Infecção com HIV." Saúde e Pesquisa 8, no. 1 (June 22, 2015): 141. http://dx.doi.org/10.17765/1983-1870.2015v8n1p141-148.
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A partir do advento da terapia antirretroviral, a qualidade de vida dos pacientes HIV positivos foi melhorada significativamente, havendo uma redução nos casos de morte por doenças oportunistas. A hepatite C representa uma comorbidade para os pacientes soropositivos. Entre os indivíduos co-infectados HIV/HCV, destacam-se os usuários de drogas por apresentarem comportamentos de risco. Assim, há a necessidade de se conhecer melhor a hepatite C, o HIV e a co-infecção e sua relação com a toxicomania. Com essa finalidade, foi realizada a presente revisão sistemática que estudou as doenças envolvidas e o perfil dos indivíduos acometidos para a co-infecção HIV/HCV. Drug Abuse: Relationship Between Hepatitis C and CO-Infection By HIV ABSTRACT. Since the discovery of anti-retroviral therapy, the life quality of HIV-infected people improved significantly, especially with regard to a decrease in mortality rates by opportunistic diseases. Hepatitis C is a co-morbidity for serum-positive patients. Illicit drug users are salient among people co-infected with HIV/HCV since they feature risk behaviors. Hepatitis C, HIV and co-infection should be better known, coupled to their relationship with drug abuse. A systemic review was undertaken which studied the diseases involved and the profile of the patients co-infected with HIC/HCV.
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KANDEMİR, Özlem, and Onur GÜLTEKİN. "Distribution of Hepatitis C Virus Genotypes in Injection Drug Users with Chronic Hepatitis C." Turkiye Klinikleri Journal of Medical Sciences 37, no. 1 (2017): 21–26. http://dx.doi.org/10.5336/medsci.2016-54118.
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TARIQ, FAQIR MUHAMMAD, IRSHAD AHMAD, HABIB SUBHANI, and Irshad Ul Haq. "HEPATITIS C." Professional Medical Journal 16, no. 02 (June 10, 2009): 169–72. http://dx.doi.org/10.29309/tpmj/2009.16.02.2890.
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I n t r o d u c t i o n : Hepatitis C is a RNA virus isolated in 1988 but still not cultured in the laboratory. Hepatitis-C infection is aserious global public health issue, WHO estimates worlds 3 % population is HCV positive. Pakistan is also facing the huge burden of thisdisease. Accurate prevalence information for hepatitis C infection is scant in Pakistan. Few population based studies are available, the mostcomprehensive being that of Luby et al which after testing a representative sample from a population of 150,000 in Hafizabad, Pakistanfound an overall sero-prevalence of 6%. This increased to 30% with increasing age. They also found sero-prevalence of 16% in householdmembers of HCV infected cases. Aslam et al reported a population prevalence of 16% from Lahore and 23.8% in Gujranwala. In our studypublished in Medical Forum showed prevalence of HCV antibodies in population attending our department of ophthalmology is 27.06%.There is no data from Pakistan about prevalence of hepatitis C in Paramedical staff. It appears that paramedical staff is at higher risk ofcontracting this infection as they are exposed to multiple risk factors like needle stick injuries. Little is known about the prevalence of HepatitisC in this group of population. The objective of our study was to assess the perceived increased incidence of Hepatitis C in this group ofpopulation. M e t h o d s & Materials:This is a retrospective audit of the data from the records kept by clinical laboratory of University MedicalCollege, Faisalabad. All paramedical staff members were invited for HCV antibody test on 13.1.2007 to 20.1.2007.Any staff member workingin those days was included in the study. Persons on holidays or did not give free informed consent was excluded from the study. Serumof blood samples were analyzed by EXCEL a one step test device for the qualitative detection of antibodies to Hepatitis C virus in serumor plasma by trained professional. This test has a relative sensitivity of 96.8%, relative specificity 99% and accuracy 98.9% as comparedto HCV EIA test. Statistical analysis was performed by SPSS system.Results: A total 80 staff members were working in the hospital at thattime, 61 attended for the test (F: 31, M: 30). We found 7 (11.4%) were HCV positive and 54 (88.52%) were HCV negative including 2 weeklypositive. Among HCV positive 4 (6.55%) were male and 3 (4.91 %) were females. Age distribution was 17 - 75 years with mean age 32.51years. Among HCV positive 3 were analyzed by ELISA technique. 2 weekly positive by EXCEL were negative by ELISA and 1 positive byEXCEL was positive by ELISA. C o n c l u s i o n : Paramedical staff is perhaps not at higher risk of contracting HCV infection. However morestudies are required to further assess this finding.
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Dudanova, Olga Petrovna, Marina E. Marina, Maria M. Pisareva, and Mikhail P. Grudinin. "Extrahepatic manifestations in patients with chronic hepatitis C." Journal of Biomedical Technologies, no. 1 (June 2014): 18–24. http://dx.doi.org/10.15393/j6.art.2014.3001.
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S., Rukmini, Deepti Pruthvi, and Chandrasekar H.R. "Seroprevalence of Hepatitis C antibody in Blood Donors." Indian Journal of Pathology: Research and Practice 6, no. 3 (part-1) (2017): 622——626. http://dx.doi.org/10.21088/ijprp.2278.148x.6317.19.
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Namıduru, Emine Siber, and Mustafa Namıduru. "Oxidative stress in viral HEPATITIS B and C." Asian Pacific Journal of Health Sciences 6, no. 4 (December 2019): 47–48. http://dx.doi.org/10.21276/apjhs.2019.6.4.10.
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Anjum, Muhammad Usman, Muhammad Safdar Khan, Nazar Muhamamd Afridi, and Syed Humayun Shah. "HEPATITIS B AND C VIRUS INFECTIONS." Professional Medical Journal 22, no. 10 (October 10, 2015): 1284–88. http://dx.doi.org/10.29309/tpmj/2015.22.10.981.
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Patients with end stage renal disease require haemodialysis as a part of theirtreatment. The incidence of hepatitis B and C virus infection is quite high in patients undergoingmaintenance haemodialysis than in general population. This risk is specifically associatedwith use of blood and its products as well as repeated intravascular access in these patients.Objectives: To determine the seropositivity of hepatitis B and C virus infection in patientsreceiving haemodialysis. Design: Descriptive cross sectional study. Setting: NephrologyDepartment, Ayub Teaching Hospital, Abbottabad, Pakistan. Period: From October 2014 toApril 2015. Methods: Five hundred patients were included in the study based on inclusionand exclusion criteria. Demographic data was recorded and detailed history was taken fromeach patient specifically about the no of blood transfusions received, the frequency of dialysisand the dialysis done in other centers. All patients were checked for the presence of hepatitisB surface antigen (HbsAg) and antibodies to HCV using third generation enzyme linkedimmunoassay (ELISA). Results: Mean age of study sample was 46±5 years with 60.8 % males.Incidence of hepatitis positive cases was 164 (32.8 %), out of which 66 (13.2 %) patients wereHBV positive and 98 (19.08 %) patients were HCV positive. The hepatitis B and C infectionswere more common in males than females. Seropositivity of HBV and HCV was higher (HBV18.1 % and HCV 22.2 %) among haemodialysis patients who have received more than threeblood transfusions. The frequency of HBV and HCV infections increases significantly with theincrease in frequency of dialysis, with 49 (17.11 %) patients were HBV positive and 70 (24.5%) patients were HCV positive cases, who have received haemodialysis for more than fivetimes. There were 48 (15.7 %) HBV positive cases as well as 68 (22.3 %) HCV positive cases inpatients who have received their treatment from a single center. Conclusion: Hepatitis B andC infection is quite common in patients undergoing haemodialysis. The risk of these infectionscan be reduced by following infection control guidelines, proper training of the staff and strictscreening of blood and blood products specifically for hepatitis C virus.
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Aisyi, Mururul, and Alan R. Tumbelaka. "Pola Penyakit Infeksi pada Thalassemia." Sari Pediatri 5, no. 1 (December 6, 2016): 27. http://dx.doi.org/10.14238/sp5.1.2003.27-33.
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Pasien thalassemia rentan terhadap infeksi akibat faktor penyakitnya maupun akibatpengobatan. Kelebihan besi yang terjadi akibat transfusi berulang mempengaruhi sistimimun, menekan aksi kemotaksis fagositosis, mikrobiosidal leukosit mononuklear danpolimorfonuklear. Penularan infeksi melalui transfusi seperti virus hepatitis, HIV danCMV merupakan komplikasi transfusi yang ditakuti. Infeksi virus hepatitis yangditularkan melalui transfusi antara lain hepatitis A, Hepatitis B, hepatitis C dan hepatitisD. hepatitis C mungkin merupakan penyebab utama sirosis hepatitis pada pasienthalassemia yang mendapat transfusi. Infeksi bakteri S. pneumoniae merupakan penyebabterbanyak bakteremia terutama pada pasien thalassemia yang menjalani operasisplenektomi. Osteomielitis yang terjadi akibat infeksi tulang yang mengalami infarkbiasanya disebabkan oleh spesies Salmonella. Vaksin polisakarida pneumokokusdirekomendasikan pada anak 2 tahun atau lebih dan ulangan diberikan setelah 3-5 tahunpada pasien thalassemia di bawah umur 10 tahun. Infeksi parasit malaria pada thalassemiasangat rendah; terdapat bukti yang terbatas bahwa perubahan respons imun pada pasiendengan varian gen globin mungkin berperan penting pada resistensi terhadap malaria.Mengingat banyaknya penyakit atau komplikasi yang timbul pada pasien thalassemiamaka perlu dilakukan pemantauan seumur hidup.
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Drochioi, Ana Simona, Evelina Moraru, Bogdan Diaconu, and Dan Cristian Moraru. "Hematological aspects in viral hepatitis C in children." Romanian Medical Journal 65, no. 3 (September 30, 2018): 196–201. http://dx.doi.org/10.37897/rmj.2018.3.7.
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Sajjad, Aiza, Shahnawaz Gardezi, Fatima Mukhtar, Amna Anjum, Qiarush Saeed, and Noor Dawood. "HEPATITIS C VIRUS (HCV) INFECTION." Professional Medical Journal 22, no. 11 (November 10, 2015): 1403–8. http://dx.doi.org/10.29309/tpmj/2015.22.11.871.
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Background: With a high magnitude of hepatitis C in the country and theburden still rising it was imperative to assess the knowledge of HCV infected individuals, whichwould determine the further spread of the disease or otherwise based on the adoption of goodpractices by these patients. Objectives: To evaluate the knowledge and practice regardingHCV in Hepatitis C patients presenting at Ghurki Trust Teaching Hospital, Lahore and toformulate recommendations based on study results to improve knowledge about hepatitisC. Study Design: Descriptive cross-sectional study. Setting: Ghurki Trust Teaching Hospital(GTTH), Lahore. Period: January to May 2015. Methods: The patients of hepatitis C registeredat GTTH for treatment were included in the study after obtaining voluntary informed consentfrom the respondents and approval of the study from the institutional ethical review board. Theconvenience non-probability sampling technique was used to recruit 169 study participants.A pre-tested structured questionnaire was used to collect information, which was recordedand analyzed using the statistical package for social sciences version 21.0. Data is describedin the form of frequencies and percentages for categorical variables and mean and standarddeviation for continuous variable. Results: Of the 169 HCV patients, 110(65%) had heard ofhepatitis C before acquiring it, the popular source of information regarding HCV was identifiedas relatives by 67(39.8%) of the patients. 70(41.4%) of the respondents were aware of a virusbeing the cause of hepatitis C, 140(82.8%) knew that HCV can be spread through sharinginjecting equipment, nearly half the respondents 87(51.5%) had asked their family membersto get tested for HCV and 68(40.2%) patients practiced safe sex. Conclusion: Majority of therespondents had heard of HCV before acquiring the disease. A large proportion of patients wereaware of the disease being spread through sharing injecting equipment. Half of the patients hadtheir family members tested for HCV. But less than half practiced safe sex.
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Azam, Golam, Shahinul Alam, Abdullah Saeed Khan, Rubayat Sheikh Giasuddin, and Mobin Khan. "High Prevalence of Diabetes Mellitus among Adult Patients with Viral Hepatitis C than Hepatitis B." International Journal of Life-Sciences Scientific Research 3, no. 5 (September 2017): 1365–69. http://dx.doi.org/10.21276/ijlssr.2017.3.5.17.
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Silva, Rafael de Azevedo, Marina Haber de Souza, Marina Pinto de Souza Caldeira, Lorena Fecury Tavares, Ana Paula Santos Oliveira Brito, Herbert Paulino Cordeiro, Carla Daniele Nascimentos Pontes, Hamilton Cezar Rocha de Garcia, and Rodrigo Bona Maneschy. "COINFECÇÃO DE HEPATITES VIRAIS E HIV NA REGIÃO NORTE DO BRASIL." Revista Eletrônica Acervo Científico 4 (April 1, 2019): e498. http://dx.doi.org/10.25248/reac.e498.2019.
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Esse artigo buscou realizar uma coleta de dados sobre a prevalência da coinfecção entre Hepatites Virais e HIV no Brasil, especificando a região Norte. Foi realizado um levantamento dos descritores nas línguas portuguesa, inglesa e espanhola no DECS (Descritores em Saúde) e no MESH (Medical Subject Headings) para coletar artigos nas bases de dados Scielo, PubMED e LILACS do recorte temporal de 2014 a 2018, além da coleta de informações do SINAN. Foi encontrado um total de 457 artigos e após a exclusão por critérios, remanesceu 13 artigos e 1 Boletim Epidemiológico. Não foram encontrados dados relevantes de Hepatite A, Hepatite Delta e Hepatite E. Na região norte do Brasil foi encontrado 2,0% de prevalência da Hepatite B e 8,9% para a Hepatite C. Logo, reconhecer a epidemiologia da coinfecção das hepatites virais com o HIV na região Norte brasileira é importante para um contexto de agilização do diagnóstico.
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OKUTAN, Oğuzhan, and Ömer AYTEN. "Hepatitis C and pulmonary fibrosis." Tuberkuloz ve Toraks 65, no. 2 (June 28, 2017): 131–37. http://dx.doi.org/10.5578/tt.35288.
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Aquino, José Américo, Katia Abrahim Pegado, Lílian Patrícia Barros, and Luiz Fernando Almeida Machado. "Soroprevalência de infecções por vírus da hepatite B e vírus da hepatite C em indivíduos do Estado do Pará." Revista da Sociedade Brasileira de Medicina Tropical 41, no. 4 (August 2008): 334–37. http://dx.doi.org/10.1590/s0037-86822008000400003.
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As hepatites B e C continuam sendo um importante problema de saúde pública no Brasil. Neste estudo, determinou-se a prevalência de marcadores sorológicos para as hepatites B e C em indivíduos do Estado do Pará, atendidos no Laboratório Central de Saúde Pública do Pará, no período de janeiro de 2002 a dezembro de 2005. Foram realizados 11.282 exames para a pesquisa do HBsAg, 2.342 para o anti-HBc e 5.542 para o anti-vírus da hepatite C. A prevalência de HBsAg foi de 3,6% e predominou na faixa etária de 20 a 29 anos, enquanto que o anti-HBc foi observado em 37,7% dos indivíduos. A prevalência do antivírus da hepatite C foi de 3,6% e predominou entre indivíduos acima de 50 anos. Assim, as freqüências dos marcadores encontradas no Pará foram mais altas que em vários outros estados do país, sugerindo a necessidade de medidas de saúde publica mais eficazes no combate a estes agravos na região.
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Shahbaz, Tazeem, Ghulam Farid, Raja Sajjad Asghar, and Abdul Rashid. "HEPATITIS B AND C." Professional Medical Journal 22, no. 11 (November 10, 2015): 1383–89. http://dx.doi.org/10.29309/tpmj/2015.22.11.859.
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Background and Aims: The working conditions of Health care workers (HCW’S)expose them for a constant threat of contracting and spreading hepatitis B (HBV) and C virus(HCV) not only to their patients but family members as well. The aim of this study was to assessthe knowledge and attitude toward hepatitis B and C infection among the health-care workersand correlate the level of awareness to their behavior towards prevention of the disease. StudySettings: The study was conducted in Rashid Latif medical college and its two affiliated hospitals(Arif memorial teaching hospital and Hameed Latif Hospital). Study Design: Descriptive crosssectional study. Methodology: A closed ended questionnaire was designed which consistsof questions for evaluating the knowledge and attitude of the participants regarding hepatitisB and C infection. Sampling was done by convenient method. 350 participants took part inthe study, which includes physicians, nurses and lab Technicians. Using the SPSS 16, we didstatistical analysis. Results: Total 350 health care workers filled the forms. 52.6 %( 184) of themwere nurses with 25.7% (90) physicians, and Lab workers were 21.7 %( 74). The mean age ofthe participants was 25.9 years with a range from 17-59 years. The service length of 73.2% ofhealth care workers was noted to be 1-5 year. (97.7%) participants know about hepatitis B andC. 88.6% identified blood and blood products, needles and sharps and 68.6% marked sexualintercourse routes of transmission. 56% gave opinion that Hepatitis B and C is a noso-comialinfection. 70.3% reported that both infections are widely transmitted like HIV/AIDS. Almost all ofthe participants (83.7%) mentioned that they are in a position to acquire these infections becauseof their duty with patients 88% of the respondents reported vaccination against Hepatitis B asa tool of prevention. Proper disposal of sharps, a needle and blood product as a preventingmeasure was also written by 88%of participants. A lot of them believe that transmission of theseinfections can be prevented by avoiding needle/sharps injury (73.7%) and casual sex (61.1%).82.9 mentioned wearing of gloves while in contact with patients and 80.6% said that adequatedisposal of sharps are the best ways of prevention. Complete vaccination for the hepatitis Bwas reported by 47.9 %( 174) with 36 %( 126) was partially vaccinated and 14.8 %( 52) were notvaccinated at all. No specific reason was identified for lack of vaccination. It is noted that morefemales (87.7%) and physician (88.9%) and Nurses (88.2%) have completed the vaccinationschedule than the Lab. Technicians (75%). Conclusion: There is a need of extensive healtheducation campaign for training of HCWs to control and prevent the spread of these infections.
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Indrasari, Nuri Dyah, Ina Susianti Timan, and Pustika Amalia. "PERBEDAAN KOLAGEN IV DI KERUSAKAN HATI DAN INFEKSI HEPATITIS C PASIEN TALASEMIA DENGAN KELEBIHAN ZAT BESI (Diferrence of Collagen IV in Liver Damage and Hepatitis C Infection in Iron Overload Thalassemia Patients)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 22, no. 1 (April 14, 2018): 1. http://dx.doi.org/10.24293/ijcpml.v22i1.1214.
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Thalassemia patients who receive repeated blood transfusions are at risk of iron overload and hepatitis C infection. Iron overload cancause iron deposit in many organs, including the liver. Iron deposits in the liver and hepatitis C infection can cause chronic inflammationof the liver and induce hepatic stellate cells to produce Extra Cellular Matrix (ECM) causing liver fibrosis. Laboratory diagnosis of liverfibrosis is based on direct and indirect markers. Collagen IV is a direct marker reflecting ECM degradation in liver fibrosis. AlanineTransaminase (ALT), Aspartate Transaminase (AST) and AST/ALT ratio are indirect markers reflecting liver cell damage due to liverfibrosis. The aim of this study was to investigate the difference of Collagen IV in liver damage and hepatitis C infection in thalassemiapatients with iron overload. Collagen IV was measured using ELISA, while ALT and AST were measured by enzymatic colorimetric assay.Fifty eight thalassemia patients with iron overload, 29 with hepatitis C and 29 without hepatitis C were studied. This study showed nosignificant difference in Collagen IV level, ALT, AST activity and AST/ALT ratio between subjects with and without hepatitis C(p 0.131,0.243, 0.256 and 0.726) and no significant correlation was found between collagen IV level and ALT activity, and between collagen IVand AST/ALT ratio (p 0.160 and 0.509). These findings indicate that Collagen IV showed no correlation with liver damage and hepatitisC infection in thalassemia patients with iron overload.
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Duran, Fatih, Ali Kaya, Aslıhan Zararsız, İrfan Oğuz Şahin, Betül Aslaner Aldemir, Pelin Kekeç Bostancı, and Ceylan Cura. "Hastanemize Başvuran 0-18 Yaş Arası Çocuklarda Hepatit B, Hepatit C ve Hepatit D Seroprevalansı." Journal of Pediatric Infection 11, no. 1 (March 30, 2017): 1–6. http://dx.doi.org/10.5578/ced.57385.
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Oliveira, Evaldo Hipólito de, Elison Costa Holanda, Antonia Jackeline Araújo de Almeida, Roseane Mara Cardoso Lima Verde, Francisco das Chagas Araújo Sousa, Sâmia Moreira de Andrade, and Maurício Almeida Cunha. "Aspectos clínicos e epidemiológicos dos casos de hepatite C no Estado do Maranhão, Brasil." Research, Society and Development 9, no. 7 (May 1, 2020): e120973720. http://dx.doi.org/10.33448/rsd-v9i7.3720.
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As hepatites virais são doenças infecciosas, com alta morbidade universal e constituem importante problema de saúde pública. O objetivo do presente estudo foi analisar o perfil clínico e epidemiológico dos casos de hepatite C no estado do Maranhão. Trata-se de um estudo epidemiológico, retrospectivo e descritivo de cunho populacional, utilizando-se dados secundários, no qual foi realizada uma pesquisa de casos por hepatite viral tipos C notificados no período de 2009 a 2018, obtidos no Sistema de Informação de Agravos de Notificação (SINAN). Foram avaliados aspectos relacionados ao gênero, faixa etária, raça, escolaridade, fonte mecânica da infecção, classificação final, formas clínicas e de diagnóstico laboratorial e por fim a quantidade de casos no Estado. Tabularam-se os dados, utilizando os programas TABNET e Microsoft Office Excel 2019. No período da pesquisa foram encontrados 1584 casos de hepatites C, onde o maior número de casos foi em 2011, totalizando 223 notificações (14%) e o menor correspondeu em 2017 (5,55%). Os indivíduos mais acometidos pela doença foram do gênero masculino (55,7%), com faixa etária entre 40 a 50 anos (53,9%). A etnia predominante foi à parda (51,6%) e 25,3% dos pacientes apresentaram grau Ensino médio completo e a principal fonte de infecção foi a sexual (11,6%) e transfusional (10,8%). A forma crônica dos casos de hepatite C notificados correspondeu a 89%. Enquanto que a forma de diagnóstico laboratorial foi a anti-HCV. Estes dados permitem orientar decisões de saúde pública, contribuindo para o planejamento, gestão e avaliação de intervenções para o controle e prevenção de hepatite C no Maranhão.
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Daidano, Jeando Khan, Nazia Azam Yusfani, and Bilqees Daidano. "DIABETES MELLITUS." Professional Medical Journal 25, no. 06 (June 9, 2018): 881–86. http://dx.doi.org/10.29309/tpmj/18.4535.
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Valente, Vanderléia Bárbaro, Dimas Tadeu Covas, and Afonso Dinis Costa Passos. "Marcadores sorológicos das hepatites B e C em doadores de sangue do Hemocentro de Ribeirão Preto, SP." Revista da Sociedade Brasileira de Medicina Tropical 38, no. 6 (December 2005): 488–92. http://dx.doi.org/10.1590/s0037-86822005000600008.
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Este estudo envolveu 25.891 doadores de sangue que compareceram pela primeira vez ao Hemocentro de Ribeirão Preto, entre 23/06/1996 e 22/06/2001. Seu objetivo foi estudar a positividade de marcadores sorológicos das hepatites B e C em testes de triagem e estimar a prevalência de infecção atual ou pregressa pelos vírus de ambas as hepatites, através da análise dos resultados de testes confirmatórios. Estudaram-se dados do Hemocentro e do Hospital das Clínicas da Faculdade de Medicina, coletando-se informações referentes ao doador e aos resultados dos testes sorológicos. A população foi composta majoritariamente por homens (83,6%) de 26 a 45 (64%) anos de idade. Os valores de positividade nos testes da triagem foram 0,6% (IC95%: 0,54 0,72) para o HBsAg e 1,2% (IC95%: 1,02 1,28), para o anti-HCV. Os valores da prevalência, nos testes confirmatórios, foram 0,2% (IC95%: 0,16 0,28), para a hepatite B, e 0,3% (IC95%: 0,24 0,38) para a hepatite C.
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Ish, Pranav. "Clinical Correlates of Hepatitis B or Hepatitis C Coinfections in People Living with HIV/AIDS (PLHIV)." Journal of Advanced Research in Medicine 05, no. 03 (July 12, 2018): 7–14. http://dx.doi.org/10.24321/2349.7181.201813.
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Gastaminza Landart, Pablo. "FROM THE DICOVERY OF NON-A, NON-B HEPATITIS VIRUS TOWARDS HEPATITIS C VIRUS ELIMINATION." Anales de la Real Academia Nacional de Farmacia, no. 86(04) (2020): 291–98. http://dx.doi.org/10.53519/analesranf.2020.86.04.07.
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In october 5 2020, the Nobel Assembly and the Nobel Committee for Physiology or Medicine, announced that three scientists Drs. Harvey Later, Michael Houghton and Charles Rice were the awarded with the Nobel prize in Medicine 2020 “for the discovery of the hepatitis C virus”. Hepatitis C virus (HCV) in one of several viruses capable of causing chronic liver inflammation and life-threatening pathologies like cirrhosis and hepatocellular carcinoma. Dr. Harvey Alter observations at the NIH Clinical Center prompted the postulate of a virus that was different from the hepatitis A and hepatitis B viruses known at that time. After many years of frustration trying to identify the infectious agent responsible for the non-A, non-B, transfusion-associated virus using conventional virological techniques, Dr. Michael Houghton succeeded not only at unequivocally identifying HCV, but also at generating essential reagents to prevent the spread of the virus through contaminated blood banks. These tools and subsequent molecular tools develop after this discovery suggest that more than 70 million people are currently infected with HCV worldwide. These studies were followed again by many years of frustrated attempts at isolating and propagating the virus in cell culture models to study basic virology on HCV. Dr. Charles Rice pioneered many studies aiming at characterizing basic functions of the viral proteins for which he developed among others, reverse genetics systems and functional assays in the form of replicons, a biological tool that was instrumental to develop the current antiviral therapies. However, its pioneer reverse genetics experiments in the chimpanzee model, by which he rescued infectious virions from cloned viral genetic material, granted his presence among the awardees. In this brief review, we discuss the context in which these seminal contributions were made and how HCV research has been propelled to the point where WHO is suggesting virus eradication using the currently available therapies.
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Tagar, Muhammad Paryal, Mujeeb Rehman Abbasi, Mohammad Rafique Pathan, and Hafeezullah Shaikh. "HEPATITIS B & C;." Professional Medical Journal 24, no. 02 (February 14, 2017): 278–81. http://dx.doi.org/10.29309/tpmj/2017.24.02.508.
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Objectives: To determine the frequency of hepatitis b & c viral infection insurgical patients. Study Design: Descriptive case series. Place and Duration of Study: Thisstudy was conducted at surgical department of multiple hospitals and compares the results,JPMC Karachi, Civil Hospital Naushahro Feroze and Jamshoro, Pakistan from August 2014 toDecember 2015. Methodology: All 2645 patients were admitted for emergency and electivesurgery. All patients taken detail history regarding demographic parameter and risk factorslike previous surgery, blood transfusion, barbar, Road Traffic accident, haemodialysis, Tattoos/body piercing, injecting drug user, family history of hepatitis, previous history of jaundiceand Hospitalization. Hospital laboratory was used for screened HBsAg and Anti HCV usingimmunochromatography (ICT method). Patients excluded who were those did not need thesurgery or known case of HBsAg and Anti HCV. Data collected was entered into and analyzedby using statistical package for the social science – 20. Results: Out of 2645 patients, maleto female ratio were 1.9:1. The mean age was 40.2+6.12years (20 to 60 years). Out of 2645patients, Anti HCV was positive in 288(10.88%) cases followed by HBsAg was in 152(5.74%)cases. While both positive in 36 (1.36%) cases. We observed Previous surgery was main riskfactor in the reactive 156(32.77%) cases followed by Barbar, Blood transfusion were 74(15.54%)and 47(9.87%) respectively. Conclusion: We conclude that preoperatively screening of hepatitisB and C should be performed.
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Temoçin, Fatih, Hatice KÖSE, and Tuğba SARI. "Seroprevalence of Hepatitis B, Hepatitis C and HIV in Police School Students." Flora the Journal of Infectious Diseases and Clinical Microbiology 22, no. 3 (September 1, 2017): 110–14. http://dx.doi.org/10.5578/flora.61842.
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Feldrihan, Vasile, Andreea Benea, and Monica Lia Junie. "Long-term Antiviral Hepatitis C treatment associated with Rods and Ring Cytoplasmic antibodies." Medicine and Pharmacy Reports 92, no. 1 (January 27, 2019): 87–90. http://dx.doi.org/10.15386/cjmed-996.
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Aim. Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".Method. Clinical case report.Results. A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response.Conclusion. This is the first reported clinical case of a patient with cytoplasmic filamentous rods and rings autoantibodies associated with chronic hepatis C from the Clinical Hospital IRGH Prof. Dr. O. Fodor Cluj-Napoca, Romania. The presence of these antibodies appears to be triggered by antiviral therapy. Although these are newly identified antibodies, they could be used as serological markers for detecting patients at risk of developing associated autoimmune pathologies or nonresponders to the antiviral therapy. Likewise, their detection could identify patients with occult hepatitis C infection.
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De Farias, Cleilton Sampaio, Ricardo Antunes Dantas de Oliveira, and Maurício R. M. P. da Luz. "O mapa das hepatites virais no Acre: entre territórios e territorialidades." Revista Brasileira de Geografia Física 12, no. 6 (January 30, 2020): 2339. http://dx.doi.org/10.26848/rbgf.v12.6.p2339-2354.
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As hepatites virais são doenças causadas por vírus distintos (A, B, C e D), que têm em comum o acometimento particularmente forte do fígado humano. Objetivou-se mapear a distribuição das hepatites virais no Acre, no período de 2010 a 2014, por meio de dois indicadores. Esse mapeamento foi associado a proposições para explicar seus territórios, suas territorialidades e suas territorializações, sendo respectivamente os locais de maior ocorrência, as relações históricas e sociais que causaram essas enfermidades e a formação desses territórios. Em vista de tudo isto, as hepatites virais se territorializaram historicamente no Acre, possivelmente favorecidas por aspectos inadequados de vigilância epidemiológica, ligados com o controle de outras endemias que assolavam os municípios. Estes fatores, associados com as condições socioeconômicas e ambientais, com a desigualdade de renda, de escolaridade e de desenvolvimento humano desses espaços, permitiram que as relações que proporcionam a infecção e a transmissão dessas doenças fossem passadas de geração para geração. Esse processo resultou em territórios que apresentam, além de muitos casos notificados altas taxas de incidências como em Cruzeiro do Sul, Rio Branco, Tarauacá e Assis Brasil. The map of viral hepatitis in Acre: between territories and territorialities A B S T R A C TViral hepatitis are diseases caused by distinct viruses (A, B, C and D), which have in common the particularly strong involvement of the human liver. The objective of this study was to map the distribution of viral hepatitis in Acre between 2010 and 2014, using two indicators. This mapping was associated with propositions to explain their territories, their territorialities and their territorializations, being respectively the places of greatest occurrence, the historical and social relations that caused these diseases and the formation of these territories. In view of all this, viral hepatitis were historically territorialized in Acre, possibly favored by inadequate aspects of epidemiological surveillance, linked to the control of other endemic diseases that devastated the municipalities. These factors, associated with socioeconomic and environmental conditions, income inequality, schooling and human development of these spaces, allowed the relations that provide the infection and the transmission of these diseases were passed from generation to generation. This process resulted in territories that have, in addition to many cases reported high incidence rates such as Cruzeiro do Sul, Rio Branco, Tarauacá and Assis Brasil.Keywords: Viral hepatitis, Map, Territories, Acre.