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Journal articles on the topic 'Hepatitis D virus (HDV)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mhlanga, Adequate, Rami Zakh, Alexander Churkin, et al. "Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients." Mathematics 10, no. 20 (2022): 3917. http://dx.doi.org/10.3390/math10203917.

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Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

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2

Crobu, Maria Grazia, Paolo Ravanini, Clotilde Impaloni, et al. "Hepatitis C Virus as a Possible Helper Virus in Human Hepatitis Delta Virus Infection." Viruses 16, no. 6 (2024): 992. http://dx.doi.org/10.3390/v16060992.

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Previous studies reported that the hepatitis C virus (HCV) could help disseminate the hepatitis D virus (HDV) in vivo through the unrelated hepatitis B virus (HBV), but with essentially inconclusive results. To try to shed light on this still-debated topic, 146 anti-HCV-positive subjects (of whom 91 HCV/HIV co-infected, and 43 with prior HCV eradication) were screened for anti-HDV antibodies (anti-HD), after careful selection for negativity to any serologic or virologic marker of current or past HBV infection. One single HCV/HIV co-infected patient (0.7%) tested highly positive for anti-HD, bu

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3

Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "Hepatitis D Virus Diagnosis by Isolation, Characterization, Treated with Antibodies and Evaluating the Patients." Journal of Surgical Nursing and Post Operative Nursing Care 3, no. 2 (2025): 9–17. https://doi.org/10.5281/zenodo.15523922.

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<em>Hepatitis B virus (HBV) is necessary for the reproduction and dissemination of the hepatitis D virus (HDV), a distinct disease. Since HDV employs the HBV surface antigen as its envelope protein, it must co-infect or superinfect with HBV in order to produce illness. Compared to HBV alone, an HDV infection can clinically cause more severe liver damage. In patients with acute HBV-HDV coinfection, the sequential spread of HBV and HDV may be reflected by a biphasic course and two different peaks in blood alanine aminotransferase. Cirrhosis and liver failure may progress more quickly in cases of

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4

Chu, Chia-Ming, Chau-Ting Yeh, and Yun-Fan Liaw. "Low-Level Viremia and Intracellular Expression of Hepatitis B Surface Antigen (HBsAg) in HBsAg Carriers with Concurrent Hepatitis C Virus Infection." Journal of Clinical Microbiology 36, no. 7 (1998): 2084–86. http://dx.doi.org/10.1128/jcm.36.7.2084-2086.1998.

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Assays of hepatitis B virus (HBV) replication and antigen expression in HBV surface antigen (HBsAg) carriers with concurrent hepatitis C or D virus (HCV or HDV) infection revealed that HCV and HDV can suppress HBV replication but that HCV also substantially suppresses HBV surface protein expression. HBsAg carriers with concurrent HCV infection thus have low-level viremia and intracellular HBsAg.

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Schinas, Georgios, Nikolina Antonopoulou, Sofia Vamvakopoulou, et al. "Prevalence of Hepatitis D in People Living with HIV: A National Cross-Sectional Pilot Study." Viruses 16, no. 7 (2024): 1044. http://dx.doi.org/10.3390/v16071044.

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This study assesses the prevalence of hepatitis D virus (HDV) in people living with HIV (PLWHIV) in Greece. Given the compounding effects of HDV and hepatitis B (HBV) on liver disease progression, as well as the emergence of new therapeutic options such as bulevirtide, understanding regional disparities and the epidemiological impact of such co-infections is vital. A cross-sectional analysis was conducted utilizing 696 serum samples from PLWHIV attending five major university hospitals. The methodology included HDV antibody detection by ELISA and HDV RNA confirmation. Of the 30 HBsAg-positive

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Farci, Patrizia, Grazia Anna Niro, Fausto Zamboni, and Giacomo Diaz. "Hepatitis D Virus and Hepatocellular Carcinoma." Viruses 13, no. 5 (2021): 830. http://dx.doi.org/10.3390/v13050830.

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Hepatitis D virus (HDV) is a small, defective RNA virus that depends on hepatitis B virus (HBV) for virion assembly and transmission. It replicates within the nucleus of hepatocytes and interacts with several cellular proteins. Chronic hepatitis D is a severe and progressive disease, leading to cirrhosis in up to 80% of cases. A high proportion of patients die of liver decompensation or hepatocellular carcinoma (HCC), but the lack of large prospective studies has made it difficult to precisely define the rate of these long-term complications. In particular, the question of whether HDV is an on

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7

Udosen, Joseph E., Euphoria C. Akwiwu, Dennis A. Abunimye, Utibe-Abasi Felix, David U. Akpotuzor, and Josephine O. Akpotuzor. "Prevalence of Hepatitis B, C and D Infections in Preoperative Patients at a Tertiary Hospital in Southern Nigeria." Sokoto Journal of Medical Laboratory Science 8, no. 1 (2023): 40–43. http://dx.doi.org/10.4314/sokjmls.v8i1.5.

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Patients going for surgical operations are required to be screened for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among other transmissible infections. This is necessary for better assessment of the patient's condition alongside the need for extra precautions during surgery. Hepatitis D virus (HDV) infection is not commonly reported but occurs in association with commonly reported but occurs in association with that of hepatitis B virus. The epidemiology of this co-infection is worth investigating, as it constitutes a more aggressive form of hepatitis Following due ethical

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Tserashkou, D. V., V. M. Mitsura, E. V. Voropaev, and O. V. Osipkina. "VIRAL COINFECTIONS IN PATIENTS WITH CHRONIC HEPATITIS B: THEIR PREVALENCE AND CLINICAL SIGNIFICANCE." Hepatology and Gastroenterology 4, no. 2 (2020): 171–76. http://dx.doi.org/10.25298/2616-5546-2020-4-2-171-176.

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Background. Hepatitis B virus (HBV) infection remains a global public health problem. Objective – to analyze the prevalence of viral coinfections with human immunodefciency virus (HIV), hepatitis C virus (HCV), hepatitis delta virus (HDV), TT-viruses and SENV in patients with chronic hepatitis B (CHB) and to assess their inﬂuence on liver disease severity. Material and methods. The observational cross-sectional study included 287 patients with chronic hepatitis B virus (HBV) – those with monoinfection and coinfected with HIV, HCV, HDV. Routine hematological and biochemical tests were performed

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Takahashi, Masaharu, Tsutomu Nishizawa, Yuhko Gotanda, et al. "High Prevalence of Antibodies to Hepatitis A and E Viruses and Viremia of Hepatitis B, C, and D Viruses among Apparently Healthy Populations in Mongolia." Clinical Diagnostic Laboratory Immunology 11, no. 2 (2004): 392–98. http://dx.doi.org/10.1128/cdli.11.2.392-398.2004.

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ABSTRACT The prevalence of infection with hepatitis A virus (HAV), HBV, HCV, HDV, and HEV was evaluated in 249 apparently healthy individuals, including 122 inhabitants in Ulaanbaatar, the capital city of Mongolia, and 127 age- and sex-matched members of nomadic tribes who lived around the capital city. Overall, hepatitis B surface antigen (HBsAg) was detected in 24 subjects (10%), of whom 22 (92%) had detectable HBV DNA. Surprisingly, HDV RNA was detectable in 20 (83%) of the 24 HBsAg-positive subjects. HCV-associated antibodies were detected in 41 (16%) and HCV RNA was detected in 36 (14%) s

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Makiala-Mandanda, Sheila, Frédéric Le Gal, Nadine Ngwaka-Matsung, et al. "High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo." Journal of Clinical Microbiology 55, no. 5 (2017): 1299–312. http://dx.doi.org/10.1128/jcm.01847-16.

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ABSTRACTThe majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic of Congo (DRC) test negative for antibodies against yellow fever virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested for hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the DRC. On a total of 498 serum samples collected fr

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Dr, Qurat ul Ain Asghar Dr Ateeb Parvez Dr Rao Tayyaba Noor. "A DESCRIPTIVE STUDY ON PREVALENCE, PATTERN AND COINFECTION OF HEPATITIS VIRUSES IN ACUTE INFECTIOUS HEPATITIS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9603–8. https://doi.org/10.5281/zenodo.2859406.

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<strong><em>Introduction:</em></strong><em> There is fluctuation of information with respect to seroprevalence and coinfection of hepatitis infections. Our goal was to decide the greatness, example and coinfection of hepatitis infections in clinically associated cases with intense irresistible hepatitis. <strong>Techniques:</strong> This illustrative examination was led in the Department of Pathology </em> <em>In Rawalpindi Medical College over a time of 1 year from January 2017 to December 2018. All the se-rum examples taken from subjects (n= 600 in study gathering and n=200 in control gather

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Montoya-Guzman, Melissa, Jaime Martinez, Diana Castro-Arroyave, Carlos Rojas, and Maria-Cristina Navas. "Epidemiology and Genetic Diversity of Hepatitis B Virus and Hepatitis Delta Virus Infection in Indigenous Communities in Colombia." Microorganisms 11, no. 7 (2023): 1739. http://dx.doi.org/10.3390/microorganisms11071739.

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Despite the universal vaccination program, there are still regions and territories with a high prevalence of Hepatitis B Virus infection (HBV), such as the Amazon basin, where several indigenous communities live. Additionally, Hepatitis Delta Virus (HDV) is a defective that requires the hepatitis B surface antigen (HBsAg) for the assembly and release of de novo viral particles. Therefore, hepatitis D could be the result of HBV/HDV coinfection or HDV superinfection in individuals with chronic hepatitis B. Among the high prevalence HDV populations are indigenous communities of America. This stud

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Schlaak, Jörg F. "Current Therapy of Chronic Viral Hepatitis B, C and D." Journal of Personalized Medicine 13, no. 6 (2023): 964. http://dx.doi.org/10.3390/jpm13060964.

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The majority of chronic viral hepatitis cases are induced via infection with the hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). These patients are at increased risk for progressive liver disease leading to cirrhosis as well as hepatocellular carcinoma (HCC). HBV infection is well controlled by the currently available nucleosides as well as nucleotides, and the development of cirrhosis can be prevented. Additionally, it has been shown that HBV-induced liver fibrosis can regress during successful antiviral treatment; however, a “functional cure”, i.e., loss of HBsA

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Austin, Publishing Group. "Tackling the Burden of Viral Hepatitis in India: A Call for Collaborative Efforts." Journal of Hepatitis Research 8, no. 1 (2023): 1049. https://doi.org/10.26420/jhepatres.2023.1049.

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Viral hepatitis is defined as a widespread infectious disease involving the inflammation of liver caused by hepatitis virus A, B, C, D and E. The majority of deaths linked to viral hepatitis are caused by HBV, HCV, and HDV, which are transmitted parenterally and induce chronic hepatitis with distant sequelae like liver cirrhosis and hepatocellular cancer [1]. According to WHO latest estimates, viral hepatitis is now acknowledged as a serious public health problem in India with over 40 million people chronically infected with HBV and six to twelve million people with HCV. In a study dated in 20

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Turon-Lagot, Vincent, Antonio Saviano, Catherine Schuster, Thomas F. Baumert, and Eloi R. Verrier. "Targeting the Host for New Therapeutic Perspectives in Hepatitis D." Journal of Clinical Medicine 9, no. 1 (2020): 222. http://dx.doi.org/10.3390/jcm9010222.

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Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV infected patients (60 million) are co-infected with HDV. Chronic hepatitis D is the most severe form of viral hepatitis with the highest risk to develop cirrhosis and liver cancer. Current treatment is based on pegylated-interferon-alpha which rarely controls HDV infection and is complicated by serious side effects. The development of novel antiviral strategies based on host targeting agents has shown promising

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Yasir, Saif Jabbar, and Taghreed Abdul kareem Al- Makhzoomy. "Hepatitis delta virus (HDV)." Medical Science Journal for Advance Research 2, no. 3 (2021): 107–34. http://dx.doi.org/10.46966/msjar.v2i3.30.

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The hepatitis D virus causes liver disease. It affects all ages. Some call it "delta hepatitis" (HDV). Hepatitis D patients have previously had hepatitis B, which is why they have this illness. Hepatitis D is spread when contaminated blood or bodily fluids come into contact with an uninfected person's body. Hepatitis D can be an acute infection or a chronic illness, depending on the person. Hepatitis D can produce severe symptoms, liver damage that lasts a lifetime, and even death. Hepatitis B and D viruses can infect people at the same time (coinfection) or they might develop hepatitis D afte

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Liou, Je-Wen, Hemalatha Mani, and Jui-Hung Yen. "Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds." International Journal of Molecular Sciences 23, no. 7 (2022): 3897. http://dx.doi.org/10.3390/ijms23073897.

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Hepatitis is defined as inflammation of the liver; it can be acute or chronic. In chronic cases, the prolonged inflammation gradually damages the liver, resulting in liver fibrosis, cirrhosis, and sometimes liver failure or cancer. Hepatitis is often caused by viral infections. The most common causes of viral hepatitis are the five hepatitis viruses—hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). While HAV and HEV rarely (or do not) cause chronic hepatitis, a considerable proportion of acute hepatitis cases caused

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18

Zhang, Zhenfeng, and Stephan Urban. "Interplay between Hepatitis D Virus and the Interferon Response." Viruses 12, no. 11 (2020): 1334. http://dx.doi.org/10.3390/v12111334.

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Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, with rapid progression of liver-related diseases and high rates of development of hepatocellular carcinoma. The causative agent, hepatitis D virus (HDV), contains a small (approximately 1.7 kb) highly self-pairing single-strand circular RNA genome that assembles with the HDV antigen to form a ribonucleoprotein (RNP) complex. HDV depends on hepatitis B virus (HBV) envelope proteins for envelopment and de novo hepatocyte entry; however, its intracellular RNA replication is autonomous. In addition, HDV can amplify HBV independe

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Lee, Grace Sanghee, Michael A. Purdy, and Youkyung Choi. "Cell Culture Systems for Studying Hepatitis B and Hepatitis D Virus Infections." Life 13, no. 7 (2023): 1527. http://dx.doi.org/10.3390/life13071527.

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The hepatitis B virus (HBV) and hepatitis D virus (HDV) infections cause liver disease, including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HBV infection remains a major global health problem. In 2019, 296 million people were living with chronic hepatitis B and about 5% of them were co-infected with HDV. In vitro cell culture systems are instrumental in the development of therapeutic targets. Cell culture systems contribute to identifying molecular mechanisms for HBV and HDV propagation, finding drug targets for antiviral therapies, and testing antiviral agents. Current HBV the

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Henri, Mbia Job, Lebomo Etogo Eugene Liliane, and Njandja Seuyip Darryl Duriannie. "Contribution of Hepatitis D Virus in Liver Cancer Among Hepatitis B Virus Infected Populations of Central Africa: A Systematic Review and Meta-Analysis." International Journal of Research and Innovation in Applied Science IX, no. III (2024): 360–73. http://dx.doi.org/10.51584/ijrias.2024.90333.

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Background and aims: Hepatocellular carcinoma (HCC) is a rampant disease in sub-Saharan Africa. Viral hepatitis is currently the most common factor in the occurrence of HCC in sub-Saharan Africa. Hepatitis B virus (HBV) causes liver disease which may or may not progress to HCC. In a dual infection with Hepatitis D virus (HDV), HCC tends to have a faster turn out. Our aim is to evaluate the influence of HDV on the risk of HCC and elaborate on factors favouring HDV infection. Methods: A review of available literature in English or French was conducted in major data bases with the search terms “l

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Wille, Michelle, Hans Netter, Margaret Littlejohn, et al. "A Divergent Hepatitis D-Like Agent in Birds." Viruses 10, no. 12 (2018): 720. http://dx.doi.org/10.3390/v10120720.

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Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important impli

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Mohajan, Haradhan Kumar. "Clinical Practice, and Diagnosis and Treatment Strategies of Chronic Hepatitis D Virus (HDV)." Innovation in Science and Technology 4, no. 4 (2025): 26–32. https://doi.org/10.63593/ist.2788-7030.2025.05.003.

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Hepatitis is the liver inflammatory disease that gradually damages the liver. Hepatitis D/delta hepatitis is a liver infection caused by the hepatitis D virus (HDV). The HDV is a blood-borne pathogen and only occurs as either a co-infection with hepatitis B virus (HBV) or as a super-infection of persons with chronic HBV. It can be an acute for short-term infection or become a long-term chronic infection. In chronic infection HDV can cause serious liver damage (cirrhosis) and death at the end stage. The HDV infection is more common in Eastern Europe, South America, Africa, Central Asia, and the

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Pauly, Matthew D., and Lilia Ganova-Raeva. "Point-of-Care Testing for Hepatitis Viruses: A Growing Need." Life 13, no. 12 (2023): 2271. http://dx.doi.org/10.3390/life13122271.

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Viral hepatitis, caused by hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or hepatitis E virus (HEV), is a major global public health problem. These viruses cause millions of infections each year, and chronic infections with HBV, HCV, or HDV can lead to severe liver complications; however, they are underdiagnosed. Achieving the World Health Organization’s viral hepatitis elimination goals by 2030 will require access to simpler, faster, and less expensive diagnostics. The development and implementation of point-of-care (POC) testing methods t

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Shih, Hsuan Hui, King-Song Jeng, Wan-Jr Syu, et al. "Hepatitis B Surface Antigen Levels and Sequences of Natural Hepatitis B Virus Variants Influence the Assembly and Secretion of Hepatitis D Virus." Journal of Virology 82, no. 5 (2007): 2250–64. http://dx.doi.org/10.1128/jvi.02155-07.

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ABSTRACT Various domains of hepatitis B surface antigen (HBsAg) are essential for the assembly and secretion of hepatitis D virus (HDV). This study investigated the influences of the levels and sequences of HBsAg of naturally occurring HBV variants on the assembly and secretion of HDV. Six hepatitis B virus (HBV)-producing plasmids (three genotype B and three genotype C) and six HBsAg expression plasmids that expressed various HBsAg levels were constructed from the sera of HDV-infected patients. These plasmids were cotransfected with six expression plasmids of HDV of genotype 1, 2, or 4 into t

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Braga, Wornei Silva Miranda, Márcia da Costa Castilho, Fabiane Giovanella Borges, et al. "Hepatitis D virus infection in the Western Brazilian Amazon - far from a vanishing disease." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 6 (2012): 691–95. http://dx.doi.org/10.1590/s0037-86822012000600007.

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INTRODUCTION: A decline in hepatitis D virus (HDV) occurrence was described in Europe and Asia. We estimated HDV prevalence in the Brazilian Amazon following hepatitis B vaccination. METHODS: This is a cross-sectional survey of HDV measured by total antibodies to HDV (anti-HD T). RESULTS: HDV prevalence was 41.9% whiting HBsAg carries and was associated with age (PR = 1.96; 95% CI 1.12-3.42; p = 0.01), hepatitis B virus (HBV) infection (PR = 4.38; 95% CI 3.12-6.13; p < 0.001), and clinical hepatitis (PR =1.44; 95% CI 1.03-2.00; p = 0.03). Risk factors were related to HDV biology, clinical o

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Gomes-Gouvêa, M. S., M. C. P. Soares, G. Bensabath, et al. "Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region." Journal of General Virology 90, no. 11 (2009): 2638–43. http://dx.doi.org/10.1099/vir.0.013615-0.

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The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978–1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4 % of cases, respectively. These results confi

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Khabir, Marwa, Matthieu Blanchet, Léna Angelo, et al. "Exosomes as Conduits: Facilitating Hepatitis B Virus-Independent Hepatitis D Virus Transmission and Propagation in Hepatocytes." Viruses 16, no. 6 (2024): 825. http://dx.doi.org/10.3390/v16060825.

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A number of research studies, including ours, have spotlighted exosomes as critical facilitators of viral dissemination. While hepatitis B virus (HBV) transmission through exosomes has been studied, the focus on its satellite virus, the hepatitis delta virus (HDV), has been unexplored in this context. HDV, although being a defective virus, can replicate its genome autonomously within hepatocytes, independently of HBV. Investigations on Huh7 cells revealed an intriguing phenomenon: the HDV proteins, S-HDAg and L-HDAg, are transmitted between cells without a complete viral structure. Detailed an

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Rizzetto, Mario. "Targeting Hepatitis D." Seminars in Liver Disease 38, no. 01 (2018): 066–72. http://dx.doi.org/10.1055/s-0037-1621711.

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AbstractNew therapeutic strategies to treat chronic hepatitis D are directed to deprive the hepatitis D virus (HDV) of functions necessary to complete its life cycle that are provided by the hepatitis B virus (HBV) and by the host. Current options are (1) the block by the synthetic peptide Myrcludex B of HBV surface antigen (HBsAg) entry into cells through the inhibition of the sodium taurocholate cotransporting receptor; (2) the inhibition with lonafarnib of the farnesylation of the large HD antigen, required for virion assembly; (3) the presumed reduction by the nucleic acid polymer REP 2139

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Langat, Benard, Elisha Kimutai Kutto, Anton Andonov, et al. "Low hepatitis D co-infection among hepatitis B virus surface antigen-positive blood donors in Kenya." International Journal Of Community Medicine And Public Health 12, no. 3 (2025): 1218–22. https://doi.org/10.18203/2394-6040.ijcmph20250601.

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Background: Hepatitis delta virus (HDV) is a highly pathogenic virus, and causes rapid disease progression from fulminant hepatitis (FH) to development of hepatocellular carcinoma (HCC) in patients co-infected with hepatitis B virus (HBV). However, its exact global burden of HBV-HDV co-infections remains largely obscure, particularly in sub-Saharan Africa. The objective of this study was to determine the prevalence of anti-hepatitis delta virus (anti-HDV) in hepatitis B virus surface antigen (HBsAg)-positive blood donors from Kenya. Methods: A total of 239 HBsAg-positive serum samples, obtaine

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Heuschkel, Margaux J., Thomas F. Baumert, and Eloi R. Verrier. "Cell Culture Models for the Study of Hepatitis D Virus Entry and Infection." Viruses 13, no. 8 (2021): 1532. http://dx.doi.org/10.3390/v13081532.

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Chronic hepatitis D is one of the most severe and aggressive forms of chronic viral hepatitis with a high risk of developing hepatocellular carcinoma (HCC). It results from the co-infection of the liver with the hepatitis B virus (HBV) and its satellite, the hepatitis D virus (HDV). Although current therapies can control HBV infection, no treatment that efficiently eliminates HDV is available and novel therapeutic strategies are needed. Although the HDV cycle is well described, the lack of simple experimental models has restricted the study of host–virus interactions, even if they represent re

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Kayesh, Mohammad Enamul Hoque, Michinori Kohara, and Kyoko Tsukiyama-Kohara. "Epidemiology and Risk Factors for Acute Viral Hepatitis in Bangladesh: An Overview." Microorganisms 10, no. 11 (2022): 2266. http://dx.doi.org/10.3390/microorganisms10112266.

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Viral infections by hepatotropic viruses can cause both acute and chronic infections in the liver, resulting in morbidity and mortality in humans. Hepatotropic viruses, including hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV), are the major pathogens that cause acute and chronic infections in humans. Although all of these viruses can cause acute hepatitis in humans, HAV and HEV are the predominant causative agents in Bangladesh, where the occurrence is sporadic throughout the year. In this review, we provide an ov

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Caviglia, Gian Paolo, Alessia Ciancio, and Mario Rizzetto. "A Review of HDV Infection." Viruses 14, no. 8 (2022): 1749. http://dx.doi.org/10.3390/v14081749.

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Hepatitis D is the most severe viral hepatitis. Hepatitis D virus (HDV) has a very small RNA genome with unique biological properties. It requires for infection the presence of hepatitis B virus (HBV) and is transmitted parenterally, mainly by superinfection of HBsAg carriers who then develop chronic hepatitis D. HDV has been brought under control in high-income countries by the implementation of HBV vaccination, and the clinical pattern has changed to a chronic hepatitis D seen in ageing patients with advanced fibrotic disease; the disease remains a major health concern in developing countrie

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Nkabari, Nwika Goodnews, Jeremiah Zaccheus Awortu, and Eze Evelyn Mgbeoma. "Prevalence of Hepatitis D Virus among Hepatitis B Positive Blood Donors in Port Harcourt, Nigeria." International Blood Research & Reviews 14, no. 4 (2023): 48–56. http://dx.doi.org/10.9734/ibrr/2023/v14i4317.

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Introduction: The Prevalence of Hepatitis D Virus among Blood Donors in Port Harcourt, Nigeria is a maiden epidemiological study of Hepatitis D or delta hepatitis among the donors’ population in Port Harcourt, Rivers State. Hepatitis D (Hepatitis Delta) is a disease caused by the hepatitis D virus (HDV). It is considered to be a sub viral satellite because it can propagate only in the presence of the hepatitis B virus. The prevalence of HDV in Port Harcourt has not been reported; hence this study, bridge that knowledge gap. Methods: Using a qualitative cross sectional study design, a gen

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Jargalsaikhan, Orgil, Wenhua Shao, Mayuko Ichimura-Shimizu, et al. "Histopathological Features of Hepatocellular Carcinoma in Patients with Hepatitis B and D Virus Infection: A Single-Institution Study in Mongolia." Cancers 17, no. 3 (2025): 432. https://doi.org/10.3390/cancers17030432.

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Background: Viral hepatitis, particularly hepatitis B (HBV) and hepatitis C (HCV), is highly prevalent in Mongolia. Moreover, Mongolia has the highest prevalence of hepatitis delta virus (HDV) globally, with over 60% of HBV-infected individuals also co-infected with HDV. Since HBV/HDV infections accelerate liver disease progression more compared to HBV infection alone, urgent national health measures are required. Method: This study presents a clinicopathological analysis of 49 hepatocellular carcinoma cases surgically resected at the Mongolia–Japan Hospital of the Mongolian National Universit

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Oliveira, Marcelo Siqueira de, Romeu Paulo Martins Silva, Suiane da Costa Negreiros do Valle, Elisabeth Níglio de Figueiredo, and Dayana Fram. "Chronic hepatitis B and D: prognosis according to Child-Pugh score." Revista Brasileira de Enfermagem 70, no. 5 (2017): 1048–53. http://dx.doi.org/10.1590/0034-7167-2016-0205.

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ABSTRACT Objective: compare chronic hepatitis B patients to those superinfected with hepatitis D virus, according to Child-Pugh score regarding disease severity. Method: retrospective descriptive study, performed with 59 patients followed in the ambulatory, of which 22 (37.3%) were chronically infected with hepatitis B virus (Group HBV) and 37 (62.7%) superinfected with Delta virus (Group HBV+HDV); variables of sex, age and items of Child-Pugh score were collected by consulting medical records. Results: out of the patients, 57.6% were male, with a mean age of 30.5 years. Score A, which indicat

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Avdeeva, M. G., V. N. Gorodin, M. I. Kulbuzheva, L. P. Blazhnaya, S. R. Hasnudinova, and E. I. Kolodko. "Chronic viral mixt-hepatitis: current clinical and epidemiological aspects." Epidemiology and Infectious Diseases 20, no. 6 (2015): 19–25. http://dx.doi.org/10.17816/eid40876.

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Objective: Improvement of the diagnosis and prognosis of liver disease of viral etiology based on the analysis of clinical and epidemiological characteristics of the course and outcome of viral mixt-hepatitis. Materials and methods There are presented results of the retrospective study of 106 patients with chronic viral mixt-hepatitis (study group), which were under the medical observation for a period from two to five years between 2010 and 2014. The comparison group was consisted of 1,913 patients with chronic hepatitis C. Results and discussion The morbidity of chronic viral mixt-hepatitis

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C Okonkwo, Uchenna, Henry C Okpara, Kenneth Inaku, et al. "Prevalence and risk factors of Hepatitis D virus antibody among asymptomatic carriers of Hepatitis B virus: a community survey." African Health Sciences 22, no. 1 (2022): 504–10. http://dx.doi.org/10.4314/ahs.v22i1.59.

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Background: Hepatitis D virus (HDV) can cause a chronic infection in the presence of hepatitis B surface antigen and contribute to the burden of chronic liver disease especially in regions where chronic hepatitis B virus (HBV) infection is endemic. Aim: To determine the prevalence and risk factors of HDV among asymptomatic carriers of HBsAg in Cross River State, Nigeria. Methods: This was a cross-sectional study conducted among apparently healthy adults resident in Cross River State, Nigeria. A structured questionnaire was used to collect socio-demograhic data and risk factors for

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Le Gal, Frédéric, Samira Dziri, Athenaïs Gerber, et al. "Performance Characteristics of a New Consensus Commercial Kit for Hepatitis D Virus RNA Viral Load Quantification." Journal of Clinical Microbiology 55, no. 2 (2016): 431–41. http://dx.doi.org/10.1128/jcm.02027-16.

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ABSTRACTHepatitis D virus (HDV) is responsible for fulminant hepatitis and liver failure and accelerates evolution toward cirrhosis and hepatocellular carcinoma in hepatitis B virus (HBV)-infected patients. To date, treatment relies upon long-term administration of pegylated alpha-interferon with a sustained virological response in 30% of the patients. Very recently, new, promising anti-HDV therapies have been developed and are already being used in clinical trials. HDV RNA viral load (HDVL) monitoring must be an integral part of the management of the infected patients. However, HDV genus is c

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Lombardo, Daniele, Maria Stella Franzè, Giuseppe Caminiti, and Teresa Pollicino. "Hepatitis Delta Virus and Hepatocellular Carcinoma." Pathogens 13, no. 5 (2024): 362. http://dx.doi.org/10.3390/pathogens13050362.

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The hepatitis D virus (HDV) is a compact, enveloped, circular RNA virus that relies on hepatitis B virus (HBV) envelope proteins to initiate a primary infection in hepatocytes, assemble, and secrete new virions. Globally, HDV infection affects an estimated 12 million to 72 million people, carrying a significantly elevated risk of developing cirrhosis, liver failure, and hepatocellular carcinoma (HCC) compared to an HBV mono-infection. Furthermore, HDV-associated HCC often manifests at a younger age and exhibits more aggressive characteristics. The intricate mechanisms driving the synergistic c

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Sausen, Daniel G., Oren Shechter, William Bietsch, et al. "Hepatitis B and Hepatitis D Viruses: A Comprehensive Update with an Immunological Focus." International Journal of Molecular Sciences 23, no. 24 (2022): 15973. http://dx.doi.org/10.3390/ijms232415973.

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Hepatitis B virus (HBV) and hepatitis delta virus (HDV) are highly prevalent viruses estimated to infect approximately 300 million people and 12–72 million people worldwide, respectively. HDV requires the HBV envelope to establish a successful infection. Concurrent infection with HBV and HDV can result in more severe disease outcomes than infection with HBV alone. These viruses can cause significant hepatic disease, including cirrhosis, fulminant hepatitis, and hepatocellular carcinoma, and represent a significant cause of global mortality. Therefore, a thorough understanding of these viruses

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Tsaneva-Damyanova, Denitsa Todorova, and Lora Hristova Georgieva. "Epidemiology Pattern, Prevalent Genotype Distribution, Fighting Stigma and Control Options for Hepatitis D in Bulgaria and Other European Countries." Life 13, no. 5 (2023): 1115. http://dx.doi.org/10.3390/life13051115.

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Hepatitis D virus (HDV) is a satellite virus that causes the most aggressive form of all viral hepatitis in individuals already infected with HBV (hepatitis B virus). In recent years, there has been a negative trend towards an increase in the prevalence of chronic hepatitis D in Europe, especially among immigrant populations coming from regions endemic for the virus. The aim of this review is to analyse the current epidemiology of chronic HDV, routes of transmission, prevalent genotype, its management, prevention, fighting stigma and options for viral control in European countries, such as Bul

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Shrivastav, MS, M. Vadsmiya, and BC Patel. "Prevalence of Hepatitis D in Jaundice Patients in Tertiary Care Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 08–13. https://doi.org/10.5281/zenodo.11543459.

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<strong>Background:</strong> In 1977, Rizzetto et al in Italy identified Delta or Hepatitis D virus. Hepatitis D virus is a small RNA virus. It is a defective virus in human in sense that it requires helper function of HBV genome. The objective of this study is to determine prevalence of hepatitis D in jaundice patients attending tertiary care hospital, Ahmedabad, to determine prevalence of hepatitis D in HBsAg reactive patients, To determine various age and sex specific prevalence of Hepatitis D, and To assess severity of infection in HBV and HDV. <strong>Material & Methods:&nbs

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Petrova, T. M., E. S. Pak, R. V. Korobka, et al. "Comorbid background on the waiting list for liver transplantation. Clinical case of liver cirrhosis as a result of chronic viral hepatitis B with a delta agent in combination with cardiac arrhythmia." South Russian Journal of Therapeutic Practice 5, no. 2 (2024): 103–9. http://dx.doi.org/10.21886/2712-8156-2024-5-2-103-109.

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Hepatitis D virus is a dependent virus that depends on hepatitis B virus for replication and transmission. Chronic hepatitis D virus (HDV) is a severe form of viral hepatitis that can lead to end-stage liver disease and hepatocellular carcinoma. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis caused by HDV coinfection. Also, the presence of a comorbid background is associated with a higher rate of complications, longer hospitalization and worse survival both before and after LT. We present a cas

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Alexandrova, R., H. Hristov, P. Kirov, et al. "Chronic Viral Infections and Hepatic Oncogenesis." Acta Microbiologica Bulgarica 40, no. 3 (2024): 227–89. http://dx.doi.org/10.59393/amb24400301.

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Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are major contrib¬utors to chronic liver disease and hepatocellular carcinoma (HCC) worldwide. Discovered in the 1960s and 1980s, these viruses are associated with significant global health burdens. HBV, a member of the He¬padnaviridae family, is a partially double-stranded DNA virus responsible for chronic liver infections that can lead to HCC. Despite the success of HBV vaccination, challenges such as vaccine escape mutants and non-responders persist. HCV, a member of the Flaviviridae family and a positive-sense si

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Littlejohn, Margaret, Stephen Locarnini, and Lilly Yuen. "Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus." Cold Spring Harbor Perspectives in Medicine 6, no. 1 (2016): a021360. https://doi.org/10.5281/zenodo.13530864.

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(Uploaded by Plazi for the Bat Literature Project) Members of the family Hepadnaviridae fall into two subgroups: mammalian and avian. The detection of endogenous avian hepadnavirus DNA integrated into the genomes of zebra finches has revealed a deep evolutionary origin of hepadnaviruses that was not previously recognized, dating back at least 40 million and possibly >80 million years ago. The nonprimate mammalian members of the Hepadnaviridae include the woodchuck hepatitis virus (WHV), the ground squirrel hepatitis virus, and arctic squirrel hepatitis virus, as well as a number of members

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Littlejohn, Margaret, Stephen Locarnini, and Lilly Yuen. "Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus." Cold Spring Harbor Perspectives in Medicine 6, no. 1 (2016): a021360. https://doi.org/10.5281/zenodo.13530864.

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(Uploaded by Plazi for the Bat Literature Project) Members of the family Hepadnaviridae fall into two subgroups: mammalian and avian. The detection of endogenous avian hepadnavirus DNA integrated into the genomes of zebra finches has revealed a deep evolutionary origin of hepadnaviruses that was not previously recognized, dating back at least 40 million and possibly >80 million years ago. The nonprimate mammalian members of the Hepadnaviridae include the woodchuck hepatitis virus (WHV), the ground squirrel hepatitis virus, and arctic squirrel hepatitis virus, as well as a number of members

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Ouedraogo, Henri G., Seni Kouanda, Sara Goodman, et al. "Hepatitis B, C and Delta Viruses’ Infections and Correlate Factors Among Female Sex Workers in Burkina Faso, West-Africa." Open Virology Journal 13, no. 1 (2019): 9–17. http://dx.doi.org/10.2174/1874357901913010009.

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Background:Female Sex Workers (FSW) have increased vulnerability to viral hepatitis B, C and D transmission. Our study aimed to assess the seroprevalence of hepatitis B, C and D viruses and their associated factors among FSW in Ouagadougou, Burkina Faso.Methods:This is a cross-sectional study among FSW at least 18 years old in Ouagadougou, Burkina Faso. Data were collected from February 2013 to May 2013 using Respondent-Driven Sampling (RDS). Hepatitis B, C, and D tests were performed on FSW storage serums using fourth generation ELISA kits. Survey-weighted bivariate and multivariate logistic

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Joseph, Keva, Ciniso Sylvester Shabangu, Tyng-Yuan Jang, et al. "The Prevalence and Serological Association of Hepatitis D Virus Genotypes in Taiwan." Pathogens 10, no. 10 (2021): 1227. http://dx.doi.org/10.3390/pathogens10101227.

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Hepatitis Delta Virus (HDV) is an RNA virus that requires the presence of hepatitis B surface antigen (HBsAg) to propagate into hepatocytes, with Genotype I being more prevalent globally. However, the prevalence of HDV genotypes in Taiwan is unknown. Accordingly, a cohort including 24 chronic HBV patients who received nucleos(t)ides (NUCs) between January 2002 and July 2018 was used to determine HDV genotypes and genotype specific serological association in chronic HBV carriers. HDV-positive genotypes in 18/24 (75%) males and 6/24 (25%) females were identified among chronic HBV patients. Virem

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Ostankova, Yu V., K. A. Nogoybaeva, E. B. Zueva, K. T. Kasymbekova, S. T. Tobokalova, and A. V. Semenov. "Characterization of the Full-Length Genome Sequences and Phylogenetic Analysis of HDV Strains Isolated from Patients with Chronic HBV and HDV Infection in Kyrgyz Republic." Problems of Particularly Dangerous Infections, no. 1 (April 23, 2020): 124–32. http://dx.doi.org/10.21055/0370-1069-2020-1-124-132.

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Objective. The purpose of our work was molecular genetic characterization of the hepatitis D virus isolates, circulating in the region with high prevalence of HBV + HDV super-infection. Materials and methods. The study material was 64 blood serum samples obtained from Kyrgyz Republic residents - patients with chronic viral hepatitis B+D. The hepatitis D virus complete genomes were sequenced, followed by phylogenetic analysis. Results and discussion. Based on the phylogenetic analysis of 64 HDV samples, it was shown that HDV genotype 1 (96.9 %) predominates in the examined group compared with H

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Bhutia, Chumila Thinley, and Deepak Das. "Prevalence of hepatitis b and hepatitis d co-infection in blood donors and hospital patients in east district of Sikkim." IP Journal of Diagnostic Pathology and Oncology 9, no. 1 (2024): 40–43. http://dx.doi.org/10.18231/j.jdpo.2024.007.

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Hepatitis Delta virus (HDV) is a small RNA virus responsible for causing both acute and chronic liver disease in persons infected with Hepatitis B. Chronic HDV infection worsens the preexisting HBV-related liver damage. Several reports mention that Hepatitis B and D frequently occur together and is called co-infection. However, no major study has been done on Hepatitis D in this region. Routine screening is not done for detection of Hepatitis D. Therefore there is insufficient data on its incidence or prevalence in this part of India.The present study was conducted to determine the prevalence

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