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Dissertations / Theses on the topic 'Hepatocellular Carcinoma HSC'

Author: Grafiati

Published: 9 March 2023

Last updated: 19 July 2025

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1

龔衍峰 and Hin-fung Tony Kung. "The impact of heat on hepatocellular carcinoma (HCC)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4073867X.

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Kung, Hin-fung Tony. "The impact of heat on hepatocellular carcinoma (HCC)." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4073867X.

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3

Wu, Guang. "Role of Notch Signaling in Hepatocellular Carcinoma (HCC)." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18718.

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Liver cancer is the 6th most common cancer worldwide and Australia’s fastest growing malignancy both in incidence and mortality. Although great improvement in early diagnosis and treatment approach have been achieved during last two decades, patients with HCC still have a dismal prognosis with a mortality-to-incidence ratio close to 1, meaning that the disease is almost uniformly fatal. One of explanations for such a dismal prognosis for HCC is the existence of heterogeneity in HCC, in which HCC is composed of liver cancer stem cells and mature HCC cells. Previous data suggested that liver can

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4

Mckiver, Bryan D. "SND1-Targeted Gene Therapy for Hepatocellular Carcinoma." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5676.

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Staphylococcal nuclease and tudor-domain containing 1 (SND1) is an oncogene for a wide variety of cancers, including hepatocellular carcinoma (HCC). SND1 is a multifunctional protein regulating gene expression of proto-oncogenes and tumor suppressor genes, making SND1 a prime target for developing cancer therapeutics. This notion is especially attributed to HCC as most patients are diagnosed in advanced stages and the therapeutic options available for these patients are severely limited. In this study, we evaluated the therapeutic potential of a replication-defective adenovirus vector deliveri

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5

Pascut, Devis. "Molecular insights for overcoming Hepatocellular Carcinoma." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7859.

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2010/2011<br>SUMMARY Introduction. Hepatocellular Carcinoma (HCC) ranks fifth in frequency of cancers in the world. Orthotopic Liver Transplantation (OLT) or liver resection represents the best treatments for HCC. However, most patients cannot be subjected to potential curative OLT or resection because of extensive tumor involvement of the liver, metastasis, invasion of the portal vein or advanced underlying hepatocellular disease at the time of diagnosis. Systemic chemotherapy or chemoembolization represent a good alternative for the treatment, however drug therapy of cancer in general i

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6

Chan, Chun-Fai. "Study of cancer vaccine candidates for human hepatocellular carcinoma (HCC) /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202004%20CHAN.

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7

Tam, Hoy-kam Aegean, and 譚凱琴. "Epigenetic dysregulation of microRNA-9 (miRNA-9) in hepatocellular carcinoma (HCC)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46455425.

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8

Khan, Maheen. "AEG-1 KNOCKOUT SENSITIZES HEPATOCELLULAR CARCINOMA (HCC) CELLS TO IONIZING RADIATION." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5853.

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Liver cancer is the fourth leading cause of cancer-associated deaths globally, and among primary liver cancers, hepatocellular carcinoma (HCC) encompasses 75-85% of all cases. HCC is a highly lethal disease due to limited treatment options – only a small subset of patients qualify for surgical resection or transplantation; the remaining patients often display resistance to radiation therapy or chemotherapy. Overexpression of the oncogene astrocyte elevated gene-1 (AEG-1) is associated with poorer survival and increased tumor recurrence in HCC, and numerous studies show its role in initiation o

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9

Kienlein, Andreas. "Lebertransplantation bei Patienten mit hepatozellulärem Karzinom. Eine retrospektive Studie am Universitätsklinikum Leipzig im Zeitraum von 1994 bis 2010. Charakterisierung des Patientenkollektivs und Analyse von Einflussfaktoren auf Überleben und Outcome." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205991.

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Für Lebertransplantationen bei Patienten mit hepatozellulärem Karzinom stellt sich angesichts der defizitären Organspendesituation die berechtigte Frage, unter welchen Bedingungen diese Form der Therapie ein gutes Outcome für die Patienten verspricht und somit keine Verschwendung der ohnehin knappen Ressourcen darstellt. Ziel dieser Arbeit war es, ein Kollektiv aus 98 Patienten, die an einem hepatozellulären Karzinom erkrankten und im Zeitraum von 1994 bis einschließlich 2010 am Universitätsklinikum Leipzig eine Lebertransplantation erhielten, retrospektiv zu charakterisieren und den Einflus

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10

Chicherova, Ievgeniia. "Netrin-1 and neurons in hepatocellular carcinoma." Electronic Thesis or Diss., Lyon, 2022. https://n2t.net/ark:/47881/m60r9pbg.

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L'inflammation hépatique chronique peut entraîner des maladies chroniques du foie (MCF), notamment l'hépatite, la cirrhose et le carcinome hépatocellulaire (CHC), qui est la tumeur maligne primaire du foie la plus fréquente et le troisième cancer le plus fréquent en termes de mortalité dans le monde. Indépendamment des facteurs étiologiques, toutes les MCFs partagent de nombreux mécanismes physiopathologiques communs : réponse aux protéines non pliées (UPR), inflammation chronique et fibrose. A l'aide d'un modèle animal et d'échantillons cliniques nous avons étudié un autre dénominateur commun

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11

Shinozuka, Ken. "Effectiveness of Radiofrequency Ablation of Initial Recurrent Hepatocellular Carcinoma after Hepatectomy: Long-Term Results and Prognostic Factors." Kyoto University, 2018. http://hdl.handle.net/2433/231012.

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12

Peng, Chengyuan. "Diagnosis of Steatosis, Precancerous Lesions and Hepatocellular Carcinoma Using Infrared Microspectroscopy." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T032.

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Carcinome hépatocellulaire (CHC) est le sixième cancer et la deuxième cause de mortalité par cancer dans le monde. Dans la majorité des cas, le CHC se développe sur une maladie chronique associée à des étiologies variées telles que l'infection par le virus de l'hépatite B ou l’hépatite C, la consommation excessive d'alcool et des maladies métaboliques. Le développement des maladies chroniques du foie qui conduisent à la cirrhose puis au cancer induisent des modifications de la composition chimique des cellules et des tissus. En effet, la carcinogenèse hépatique est un processus en plusieurs ét

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13

Ramanathan, Meera, Michael Shroads, Myunghan Choi, David Wood, and Anil Seetharam. "Predictors of intermediate-term survival with destination locoregional therapy of hepatocellular cancer in patients either ineligible or unwilling for liver transplantation." PIONEER BIOSCIENCE PUBL CO, 2017. http://hdl.handle.net/10150/626078.

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Intra-arterial or percutaneous locoregional therapies (LRT) are often employed to maintain potential liver transplant (LT) recipients with hepatocellular carcinoma (HCC) within T2/Milan criteria. Predictors of survival when LRT is used as destination therapy in those who are either ineligible or unwilling for LT remain poorly defined. We evaluated predictors of 3-year survival with destination LRT in a population of cirrhotic patients diagnosed with HCC, presenting within T2 criteria, and either ineligible or unwilling for LT. The cohort surviving 3 years had a significantly lower model for en

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14

Reyes, Ryan. "Sorafenib and 2-Deoxyglucose: The Future of Hepatocellular Carcinoma Therapy." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461275086.

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15

Wang, Ruihua, and 王瑞華. "Blockade of heat shock protein 90 (HSP90) for the treatment of hepatocellular carcinoma (HCC)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41005776.

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16

Wang, Ruihua. "Blockade of heat shock protein 90 (HSP90) for the treatment of hepatocellular carcinoma (HCC)." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41005776.

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17

Chen, Dong. "Function of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in Hepatocellular Carcinoma." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2821.

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Title of Dissertation: FUNCTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7(IGFBP7) IN HEPATOCELLULAR CARCINOMA By Dong Chen. Purpose: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment, thus requiring the development of innovative and effective targeted therapies. The oncogene Astrocyte Elevated Gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates Insulin-like Growth Factor Binding Protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the rel

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18

PRATAMA, MUHAMMAD YOGI. "TRANSLATIONAL STUDIES ON MICRORNA IN HEPATOCELLULAR CARCINOMA: FROM PREDICTIVE AND PROGNOSTIC BIOMARKERS TO MOLECULAR EFFECTORS." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2973744.

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Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, represents the seventh most frequent cancer and the fourth leading cause of cancer-related death worldwide. Due to unspecific sign and symptoms along with the inefficacy of current non-invasive diagnostic tools for detecting early stages HCC, majority of patients are diagnosed at advanced stages that is no longer eligible for curative treatments. Moreover, the long-term outcome of treatments remain unsatisfactory. To overcome these problems, a better diagnostic and predictive biomarker might be one of

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19

Pourchet, Aldo Decio. "Développement de virus HSV-1 (virus de l’herpes simplex de type 1) oncolytiques ciblés pour traiter les carcinomes hépatocellulaires." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10155/document.

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Le premier objectif a été de sélectionner des promoteurs de gènes cellulaires actifs spécifiquement dans les HCC à l’aide d’une recherche bibliographique puis en utilisant la base de donnée UniGene. Leur activité a été vérifiée par RT-qPCR et CHIP dans des lignées modèles HCC et dans des hépatocytes. Ces promoteurs ont été clonés en amont de la luciférase dans la région intergénique 20 du génome HSV-1 afin d’étudier leur force d’activité, 2 types de cinétiques et leur activité différentielle en fonction du type cellulaire et dans le contexte d’une infection virale. Le deuxième objectif a été d

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20

Yuan, Ke. "THE CHARACTERIZATION OF HSA-MIR148A IN HEPATOCARCINOGENESIS." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/154268.

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Biology<br>Ph.D.<br>Chronic Hepatitis B Virus (HBV) infection is a global health problem because of its connection to acute and chronic liver diseases as well as hepatocellular carcinoma (HCC). There is increasing evidence showing that HBV contributes to HCC due to persistently high levels of trans-activating protein---hepatitis B encoded x antigen (HBxAg). Studies have shown that the HBxAg affects and alters the activity of many different transcription factors and plays an essential role in several cytoplasmic signaling transduction pathways, such as Wnt signaling pathways. One of the u

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21

PERRONE, FRANCESCA. "Development of a novel Polymer-based delivery system for siRNAs to hepatocellular carcinoma cells." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2961013.

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For Hepatocellular carcinoma (HCC) there are no effective treatments thus, the individuation of novel therapeutic approaches and molecular targets are urgent. Small interference RNA (siRNAs) are small double stranded RNAs able to induce gene silencing thus, representing an attractive therapeutic strategy. The main impediment in using siRNAs is the fast degradation rate in the biological environment. To protect siRNAs from degradation, we developed a novel delivery system based on the polymer α,β-poly-(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) derivatized with diethylene triamine (DETA) linked v

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22

LADJU, RUSDINA BTE. "The Importance of Death Receptor Pathway in Hepatocellular Carcinoma and It's Potential in the Development of Oligonucleotide Nanomedicine." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2952508.

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Hepatocellular carcinoma (HCC; primary liver cancer) is one of the most common cancers with high mortality rate worldwide. Hepatocarcinogenesis is triggered by multiple factors, such as cancer etiologies, treatment options, host factors, and lifestyle. It is a complex progressive disease involving sustained inflammatory damage, fibrosis, and cirrhosis. Numerous numbers of intrinsic and extrinsic factors leading to the alteration of various molecular and cellular events, compromising the balance between survival and apoptotic signals in the cells. Fas (CD95, Apo-1, TNFRSF6) is a member of the

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23

Valmasoni, Michele. "Nuove tecniche e tecnologie per l'aumento di sicurezza ed efficacia nel trattamento chirurgico dell'epatocarcinoma." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425536.

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Proposal and initial experience with new surgical techniques and technologies for extending hepatocellular carcinoma treatment beyond actual indications. Laparoscopic hepatic resections in cirrhotic patients with HCC. Extreme hepatic resections in cirrhotic patients with advanced HCC: a new surgical approach.

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24

Ye, Liangtao [Verfasser], and Enrico de [Akademischer Betreuer] Toni. "Novel targets and therapeutic strategies for the treatment of hepatocellular carcinoma (HCC) / Liangtao Ye ; Betreuer: Enrico de Toni." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1211957144/34.

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25

NERI, CARMELO. "Serine 249 phosphorylation and Pin1-induced isomerization activate mutant p53 R249S gain-of-function and promote cross-talk with JAK/STAT1 signalling in hepatocellular carcinoma." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908184.

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Evidences from basic and clinical studies clearly established that mutations of the tumour suppressor TP53 contribute to carcinogenesis. Unlike the majority of tumour suppressors, the TP53 gene is often found to undergo missense mutations, with a strong dominance in the DNA-binding domain. Mutant p53 proteins contribute to carcinogenesis by losing tumour suppressor activities, by exerting dominant negative effects over the wild-type allele and by acquiring gain-of-function properties. These oncogenic activities enforce tumour growth, EMT, metastasis and chemoresistance. It has been clearly dem

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26

BASELLI, GUIDO ALESSANDRO. "FUNCTIONAL CHARACTERIZATION OF A NOVEL GENETIC VARIANT PREDISPOSING TO ADVANCED FIBROSIS AND HEPATOCELLULAR CARCINOMA DEVELOPMENT IN NONALCOHOLIC FATTY LIVER DISEASE." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/718850.

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Functional characterization of a novel genetic variant predisposing to advanced fibrosis and hepatocellular carcinoma development in nonalcoholic fatty liver disease Introduzione La steatosi epatica non alcoolica (NAFLD) rappresenta la più comune tra le malattie epatiche croniche nei paesi occidentali e rappresenta una causa emergente di cirrosi epatica e carcinoma epatocellulare (HCC). Numerosi studi hanno sottolineato l'importanza di vari tratti ereditari nel modificare la suscettibilità e il decorso di questa malattia. Tuttavia, la componente ereditabile di NAFLD resta in larga misura sco

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27

Jariwala, Nidhi H. "Characterization of Staphylococcal nuclease and tudor domain containing protein 1 (SND1) as a molecular target in Hepatocellular carcinoma and Non-alcoholic steatohepatitis." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5183.

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CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS Nidhi Jariwala, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences Virginia Commonwealth University, 2017 Devanand Sarkar, M.B.B.S., PhD. Associate Professor, Department of Human and Molecular Genetics Virginia Commonwealth University Richmond, Virginia SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an onco

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Farra, Rossella. "siRNAs targeted against cell cycle related genes as tools to down regulate cell-proliferation in hepatocellular carcinoma and vascular smooth muscle cells." Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2651.

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2006/2007<br>ABSTRACT Exuberant and non-controlled cellular proliferation underlines the ethio-pathogenesis of many human pathological conditions, including tumour and non-tumour diseases. Thus, the possibility to control this complex process can be extremely useful in terms of prevention/control of disease progression, especially in the light of the limited efficacy of current therapeutic approaches. In this project we draw our attention on the down regulation of cell proliferation in the context of two human diseases, namely hepatocellular carcinoma (HCC), as an example of tumour patholog

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29

Sinha, S. "Detection of structural variations during liver cancer progression." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265927.

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Hepatocellular carcinoma (HCC) is one of the most lethal cancers in the world and accounts for the vast majority of all liver cancers. HCC develops in response to various factors including viral infections, aflatoxin, alcohol and metabolic diseases. Recent studies have highlighted substantial differences in the acquired genomic alterations depending on the causative agent. Despite such a mutagen-dependent genetic heterogeneity, HCC is almost invariably associated with an underlying inflammatory state, whose direct contribution to the acquisition of critical genomic changes is not yet clear.

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Lukowski, Sonja [Verfasser], and Rainer [Akademischer Betreuer] Zawatzky. "Wisp1 is associated with hepatitis B related human hepatocellular carcinoma and promotes proliferation or migration of HCC derived cell lines / Sonja Lukowski ; Betreuer: Rainer Zawatzky." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177148161/34.

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31

Ritorto, Maria Stella [Verfasser]. "Cancer proteomics of mouse serum and liver tissue samples to discover candidate biomarkers for hepatocellular carcinoma (HCC) in c-Myc transgenic mice / Maria Stella Ritorto." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/101545996X/34.

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32

Hansen, Ryan. "Functional and Structural Analysis of Decellularized Liver Tissue Matrix, with Potential Applications in Cancer Tissue Engineering." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1498650461817088.

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33

Robertson, Chadia L. "Analysis of the Role of Astrocyte Elevated Gene-1 in Normal Liver Physiology and in the Onset and Progression of Hepatocellular Carcinoma." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3573.

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First identified over a decade ago, Astrocyte Elevated Gene-1 (AEG-1) has been studied extensively due to early reports of its overexpression in various cancer cell lines. Research groups all over the globe including our own have since identified AEG-1 overexpression in cancers of diverse lineages including cancers of the liver, colon, skin, prostate, breast, lung, esophagus, neurons and neuronal glia as compared to matched normal tissue. A comprehensive and convincing body of data currently points to AEG-1 as an essential component, critical to the progression and perhaps onset of cancer. AEG

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34

Salvatore, Veronica <1982&gt. "Changes in tumor stiffness for early prediction of tumor response to sorafenib: a proof-of-concept study with elastosonography in an animal model of Hepatocellular Carcinoma (HCC)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3481/1/salvatore_veronica_tesi.pdf.

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Background and aims: Sorafenib is the reference therapy for advanced Hepatocellular Carcinoma (HCC). No method exists to predict in the very early period subsequent individual response. Starting from the clinical experience in humans that subcutaneous metastases may rapidly change consistency under sorafenib and that elastosonography a new ultrasound based technique allows assessment of tissue stiffness, we investigated the role of elastonography in the very early prediction of tumor response to sorafenib in a HCC animal model. Methods: HCC (Huh7 cells) subcutaneous xenografting in mice was

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Salvatore, Veronica <1982&gt. "Changes in tumor stiffness for early prediction of tumor response to sorafenib: a proof-of-concept study with elastosonography in an animal model of Hepatocellular Carcinoma (HCC)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3481/.

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Background and aims: Sorafenib is the reference therapy for advanced Hepatocellular Carcinoma (HCC). No method exists to predict in the very early period subsequent individual response. Starting from the clinical experience in humans that subcutaneous metastases may rapidly change consistency under sorafenib and that elastosonography a new ultrasound based technique allows assessment of tissue stiffness, we investigated the role of elastonography in the very early prediction of tumor response to sorafenib in a HCC animal model. Methods: HCC (Huh7 cells) subcutaneous xenografting in mice was

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36

Lang, Hauke. "Hepatozelluläres Karzinom." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137389.

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Roth, Alexander David. "Modeling Liver Diseases Using Hepatic Cell Microarrays." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544719407531728.

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Lang, Hauke. "Hepatozelluläres Karzinom." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27731.

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39

Wang, Bo. "Role of microRNAs in Hepatocarcinogenesis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1329154583.

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40

Hillemann, Annett. "Verstärkung des bystander Effektes von Suizidgentherapeutika." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2005. http://dx.doi.org/10.18452/15450.

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Die vorliegende Arbeit beschäftigt sich mit einem neuartigen proteinbasierten, suizidgentherapeutischen Ansatz zur sicheren und effektiven Behandlung von soliden Tumoren. Verwendet wurden zellpermeable Fusionsproteine auf der Grundlage des bakteriellen Enzyms Cytosin Desaminase, welches spezifisch die Umsetzung der inaktive, nichttoxische Substanz (Prodroge) 5-Fluorcytosin in den hochwirksamen, stark toxischen Wirkstoff 5-Fluoruracil katalysiert. Dieser bewirkt die selektive Zerstörung von Tumorzellen. Durch die Fusion der bakteriellen Cytosin Desaminase (bCD) mit der Sequenz des Zellpermeabi

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Teng, Kun-Yu Teng. "Molecular mechanisms underlying microRNA-122 mediated suppression of liver inflammation, fibrosis, and carcinogenesis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1511206344798557.

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LOCATELLI, LUIGI. "Expression of aVB6 integrin by Pkhd1-defective cholangiocytes links enhanced ductal secretion of Macrophage chemokines to progressive portal fibrosis in Congenital Hepatic Fibrosis." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41733.

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BACKGROUND AND AIMS: Congenital Hepatic Fibrosis (CHF) is caused by mutations in PKHD1, a gene encoding for fibrocystin, a protein of unknown function, expressed in cholangiocyte cilia and centromers. In CHF, biliary dysgenesis is accompanied by severe progressive portal fibrosis and portal hypertension. The mechanisms responsible for portal fibrosis in CHF are unclear. The αvβ6 integrin mediates local activation of TGFβ1 and is expressed by reactive cholangiocytes during cholestasis. To understand the mechanisms of fibrosis in CHF we studied the expression of αvβ6 integrin and its regulation

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Verger, Elise. "Microparticules à base d’amidon (SBMP) comme agent théranostique unique pour la radiothérapie sélective interne des tumeurs hépatiques : radiomarquage au gallium-68 et rhénium-188 et étude préliminaire in vivo." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0054/document.

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Le Carcinome Hépatocellulaire a une incidence mondiale élevée et est associé à un mauvais pronostic. Les traitements curatifs existants ne sont applicables qu’à une minorité de patients. La radiothérapie sélective interne (SIRT) est un traitement palliatif de plus en plus utilisé. Elle consiste à l’injection sélective intra-tumorale de microsphères d’yttrium-90 par infusion intra-artérielle, et repose sur deux étapes : une étape pré-thérapeutique de simulation du traitement avec l’injection de macroagrégats d’albumines marqués au 99mTc et le traitement en lui-même. Cependant les caractéristiqu

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"Mitochondrial DNA mutations in hepatocellular carcinoma (HCC) of Chinese patients." 2004. http://library.cuhk.edu.hk/record=b5892082.

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Fu Zhenming.<br>Thesis submitted in: December 2003.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (leaves 138-162).<br>Abstracts in English and Chinese.<br>List of abbreviations --- p.i<br>Abstract (in English) --- p.ii<br>摘要（中文） --- p.iii<br>Acknowledgement --- p.iv<br>Chapter Chapter 1. --- Introduction and Objectives of Study --- p.1<br>Chapter 1.1 --- Hepatocellular carcinoma in general --- p.2<br>Chapter 1.1.1 --- "Epidemiology, risk factors" --- p.2<br>Chapter 1.1.2 --- Pathology and staging --- p.4<br>Chapter 1.1.3 --- Treatme

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Ku, Chung-Yu, and 辜琮祐. "Studies on Hepatocellular Carcinoma (HCC)：I. Liver Fatty Acid-Binding Protein (L-FABP) Promotes Cellular Angiogenesis and Migration in Hepatocellular CarcinomaII. Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/e2c7f8.

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博士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>103<br>Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer and the third most common cause of cancer death worldwide. The progression of HCC relies on the formation of new blood vessels, and VEGF is critical in this process. Liver fatty acid-binding protein (L-FABP) is abundant in hepatocytes and known to be involved in lipid metabolism. Overexpression of L-FABP has been reported in various cancers; however, its role in hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated L-FABP and its association with vascular

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FONTANA, Monica. "RISK FACTORS FOR EARLY RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION." Doctoral thesis, 2014. http://hdl.handle.net/11562/713564.

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Introduzione Il carcinoma epatocellulare ( HCC ) è il tumore epatico primitivo più frequente e la sua incidenza è in aumento nei paesi occidentali. I recenti progressi nelle tecniche chirurgiche di resezione epatica e l’accurata gestione perioperatoria, rendono attuabili interventi resettivi epatici per HCC con mortalità e morbilità prossime allo 0%. Ciononostante, la sopravvivenza a lungo termine dopo epatectomia è deludente a causa dell’ elevata incidenza di recidiva, che raggiunge il 70-100 % a 5 anni. Più del 60-80 % delle recidive intraepatiche di HCC sono suscettibili di nuovi trattame

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Clifford, Corinne. "A cross sectional analysis of the association between FGF19 tumor expression and serum AFP levels in advanced HCC patients." Thesis, 2017. https://hdl.handle.net/2144/23745.

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PURPOSE: HCC is a complicated disease with high mortality rates and limited treatment options. No universal clinical or molecular classification established to inform better treatment options. There has been very limited success in determining a molecular profile that represent valid drivers in HCC patients and thus no targeted agents have obtained marketing approval. However, emerging data suggest the FGF19-pathway as a HCC driver and a potential therapeutic target. This research study aims to investigate whether the HCC prognostic risk factor, serum AFP, is predictive of FGF19 protein ex

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Willoughby, Jennifer Lynn Sherman. "Transcription factor LSF: a mitotic regulator in hepatocellular carcinoma cells." Thesis, 2016. https://hdl.handle.net/2144/20713.

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Current treatments are subpar, with late stage diagnosis and poor prognosis contributing to limited treatment options. The evolutionarily conserved, ubiquitously expressed transcription factor LSF is overexpressed in HCC, and its expression is positively correlated with disease severity. Certain small molecules, known as Factor Quinolinone Inhibitors (FQIs), specifically inhibit LSF DNA-binding activity, inhibit HCC cell proliferation in vitro and prevent tumor growth in an endogenous mouse liver cancer

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ABURAS, SAMI HUSSEIN ALI. "Role of Circulating Endothelial Progenitors cells (EPC) in patients with hepatocellular Carcinoma treated with Sorafenib." Doctoral thesis, 2017. http://hdl.handle.net/2158/1077552.

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CEENG-SHU, YU, and 余政書. "The Hemodynamics of Hepatocellular Carcinoma(HCC)：Analysis in Harmonic and RI values." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/31882007666119142274.

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碩士<br>國立臺灣大學<br>應用力學研究所<br>89<br>In this study，we measure the waveform of the blood velocity in common hepatic artery using Doppler ultrasound. Image processing and fast Fourier transform(FFT) were used to get peak velocity waveform of the normalized amplitude of individual harmonics. The harmonics of velocity waveform and RI etc. were investigated for the hemodynamics of hepatocellular carcinoma (HCC). The subjects studied were divided control group and HCC group. The Hcc group studied were further categorized into varies groups based on theirs age，sex，portal vein thrombosis(PVT)，

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