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Journal articles on the topic 'Hepatocellular carcinoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Hotta, Akihiro, Masaki Ishikawa, Toshihiro Tachikake, Noriaki Matsuura, Naoyuki Toyota, and Kazuo Awai. "Comparison of the effectiveness of celiac versus common hepatic artery injection for the detection of hepatocellular carcinoma and of the feeding artery on cone-beam computed tomographs obtained during hepatic angiography." Acta Radiologica Open 10, no. 2 (2021): 205846012199473. http://dx.doi.org/10.1177/2058460121994735.

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Background Cone-beam computed tomography (CBCT) has been widely used during transcatheter arterial chemoembolization for hepatocellular carcinoma. Purpose To evaluate the sensitivity of CBCT for the detection of hepatocellular carcinomas and the tumor feeders by comparing celiac artery (CA) and common hepatic artery (CHA) injection. Material and methods We retrospectively enrolled 30 patients (52 hepatocellular carcinoma lesions) who had undergone CBCT-assisted transcatheter arterial chemoembolization. In 17 procedures (28 hepatocellular carcinomas) we acquired CBCT scans using CA injections (

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2

CHEDID, Marcio F., Cleber R. P. KRUEL, Marcelo A. PINTO, et al. "HEPATOCELLULAR CARCINOMA: DIAGNOSIS AND OPERATIVE MANAGEMENT." ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 30, no. 4 (2017): 272–78. http://dx.doi.org/10.1590/0102-6720201700040011.

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ABSTRACT Introduction: Hepatocellular carcinoma is an aggressive malignant tumor with high lethality. Aim: To review diagnosis and management of hepatocellular carcinoma. Methods: Literature review using web databases Medline/PubMed. Results: Hepatocellular carcinoma is a common complication of hepatic cirrhosis. Chronic viral hepatitis B and C also constitute as risk factors for its development. In patients with cirrhosis, hepatocelular carcinoma usually rises upon malignant transformation of a dysplastic regenerative nodule. Differential diagnosis with other liver tumors is obtained through

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3

Van Treeck, Benjamin J., Taofic Mounajjed, Roger K. Moreira, et al. "Transcriptomic and Proteomic Analysis of Steatohepatitic Hepatocellular Carcinoma Reveals Novel Distinct Biologic Features." American Journal of Clinical Pathology 155, no. 1 (2020): 87–96. http://dx.doi.org/10.1093/ajcp/aqaa114.

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Abstract Objectives Steatohepatitic hepatocellular carcinoma is a distinct variant of hepatocellular carcinoma strongly associated with underlying nonalcoholic steatohepatitis. The molecular biology of steatohepatitic hepatocellular carcinoma is not fully elucidated, and thus we aimed to investigate the molecular underpinnings of this entity. Methods Transcriptomic analysis using RNAseq was performed on eight tumor-nonneoplastic pairs of steatohepatitic hepatocellular carcinoma with comparison to conventional hepatocellular carcinoma transcriptomes curated in The Cancer Genome Atlas. Immunohis

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4

Takamura, Hiroyuki, Ryousuke Gabata, Yoshinao Obatake, et al. "Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094814. http://dx.doi.org/10.1177/1533033820948141.

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Background and Objectives: Although cholangiolocellular carcinoma is considered a combined hepatocellular and cholangiocarcinoma, we feel that this classification is not appropriate. Therefore, we compared the diagnostic imaging findings, surgical prognosis, and pathological features of cholangiolocellular carcinoma with those of other combined hepatocellular and cholangiocarcinoma subtypes, hepatocellular carcinoma, and cholangiocarcinoma. Methods: The study patients included 7 with classical type combined hepatocellular and cholangiocarcinoma; 8 with stem cell feature, intermediate type comb

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5

Ozaki, I., K. Yamamoto, T. Mizuta, et al. "Differential expression of laminin receptors in human hepatocellular carcinoma." Gut 43, no. 6 (1998): 837–42. http://dx.doi.org/10.1136/gut.43.6.837.

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Background—Laminin receptors are involved in cell-extracellular matrix interactions in malignant cells that show invasion and metastasis. Hepatocellular carcinoma frequently shows early invasion into blood vessels, and intrahepatic and extrahepatic metastases. However, the role of laminin receptors in hepatocellular carcinoma is unknown.Aims—To examine the expression of mRNA for laminin receptors and their isoforms in hepatocellular carcinoma.Methods—The expression of several laminin receptors, including α1 integrin, α6 integrin and its isoforms α6A and α6B, β1 integrin and its isoforms β1A an

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6

Molina, D. Kimberley, and Philip T. Valente. "Lymphangitic Spread of Hepatocellular Carcinoma." Archives of Pathology & Laboratory Medicine 127, no. 1 (2003): e11-e13. http://dx.doi.org/10.5858/2003-127-e11-lsoh.

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Abstract Pulmonary lymphangitic carcinomatosis is a well-documented phenomenon caused by spread of carcinoma to the pulmonary vasculature and lymphatics, often resulting in respiratory failure and cor pulmonale. It has been described in numerous types of carcinoma, most commonly occurring with carcinomas of the breast and stomach and with choriocarcinoma. We report the case of a patient who presented with increasing shortness of breath and dyspnea on exertion. Autopsy findings revealed diffuse pulmonary vascular spread of a hepatocellular carcinoma to the lungs. To our knowledge, this is the f

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7

Takeuchi, Tamotsu, Yoshihiro Adachi, and Tomoko Nagayama. "Expression of a Secretory Protein C1qTNF6, a C1qTNF Family Member, in Hepatocellular Carcinoma." Analytical Cellular Pathology 34, no. 3 (2011): 113–21. http://dx.doi.org/10.1155/2011/578097.

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Background: Recent studies have revealed that the adiponectin-associated protein belonging to the C1qTNF family mediates various biological processes. However, the pathobiological property of C1qTNF6 in carcinogenesis remains unclear. Here, we investigated the expression status of C1qTNF6 in human hepatocellular carcinomas and subsequently attempted to determine the role of C1qTNF6 in tumor neovascularization. Methods: Immunohistochemical staining was performed to evaluate the expression of C1qTNF6 in hepatocellular carcinoma tissue specimens. Various eukaryotic recombinant C1qTNF6 proteins we

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8

Nguyen, Thuy, Daniel Phillips, Dhanpat Jain, et al. "Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma." Archives of Pathology & Laboratory Medicine 139, no. 8 (2015): 1028–34. http://dx.doi.org/10.5858/arpa.2014-0479-oa.

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Context Several immunohistochemical markers are available to establish the diagnosis of hepatocellular carcinoma. Judicious selection is essential to achieve a reliable diagnosis in limited tissue provided by liver biopsy. Objective To compare the efficacy of 5 hepatocellular markers for the diagnosis of hepatocellular carcinoma across various levels of differentiations. Design Immunohistochemistry for hepatocyte paraffin antigen 1 (Hep Par 1), polyclonal carcinoembryonic antigen (CEA), glypican-3, arginase-1, and bile salt export pump transporter was performed in 79 hepatocellular carcinomas,

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9

Breder, V. V., K. K. Laktionov, and M. I. Davydov. "PHARMACOLOGICAL THERAPY OF HEPATOCELLULAR CANCER PRACTICAL ISSUES AND SOLUTIONS." Medical Council, no. 14 (November 14, 2017): 11–23. http://dx.doi.org/10.21518/2079-701x-2017-14-11-23.

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Pharmaceutical therapy of hepatocellular carcinoma represents a major clinical issue of debate in modern oncology. Until now, Sorafenib remains the only option for the management of locally advanced and metastatic hepatocellular carcinomas, which increases the overall survival of patients. In the absence of alternative treatment, the oncologist understanding of the place, time, the strategic goal and tactical objectives of the pharmaceutical therapy of hepatocellular carcinoma at different stages of cancer is of great importance. The article considers the practical aspects of the Sorafenib the

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10

Reis, Marcio Augusto Correia Rodrigues dos, and Ronaldo Hueb Baroni. "Liver-specific magnetic resonance contrast medium in the evaluation of chronic liver disease." Einstein (São Paulo) 13, no. 2 (2015): 326–29. http://dx.doi.org/10.1590/s1679-45082015rw3159.

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ABSTRACT The hepatobiliary-specific contrast medium (gadoxetic acid – Primovist®) is primarily used to improve detection and characterization of focal hepatic lesions, such as in chronic liver disease patients with suspected hepatocellular carcinoma. Since the contrast medium is selectively taken up by functioning hepatocytes in the late hepatobiliary phase, it helps to detect typical hepatocellular carcinoma, which show low signal intensity on this phase. This imaging feature also assists in differentiating regenerative/dysplastic nodules from early hepatocellular carcinomas (with over 90% ac

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11

Torbenson, Michael. "Fibrolamellar Carcinoma: 2012 Update." Scientifica 2012 (2012): 1–15. http://dx.doi.org/10.6064/2012/743790.

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Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tum

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12

Vani, Dayanand, Rao Srijana S.P, Pushpa H.R, and Bharathi M. "Hepatocellular Carcinoma- Sarcomatoid Variant: A Rare Occurence." Indian Journal of Forensic Medicine and Pathology 10, no. 3 (2017): 242–44. http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.13.

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13

Yadav, Krohit, Kanupriya Agrawal, Manu Solanki, Nikita Jindal, Venkata Raviteja, and Reddy Gayam. "Synchronous Renal Cell Carcinoma and Hepatocellular Carcinoma - A Rare Case Report." International Journal of Science and Research (IJSR) 11, no. 2 (2022): 1025–27. http://dx.doi.org/10.21275/sr22221170303.

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14

Nault, Jean-Charles, and Eric Letouzé. "Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid." Seminars in Liver Disease 39, no. 03 (2019): 334–40. http://dx.doi.org/10.1055/s-0039-1685516.

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AbstractEach hepatocellular carcinoma displays dozens of mutations in driver and passenger genes. The analysis of the types of substitutions and their trinucleotide context defines mutational signatures that recapitulate the endogenous and exogenous mutational processes operative in tumor cells. Aristolochic acid is present in plants from the genus Aristolochia and causes chronic nephropathy. Moreover, aristolochic acid has genotoxic properties responsible for the occurrence of urothelial carcinoma. Metabolites of aristolochic acid form DNA adducts on adenine residues leading to a specific mut

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15

Jessica, Ariatna Carreto Navarrete, Antonio Calixto Estanislao, Arredondo Ruiz Pedro, et al. "A Case of Fibrolamellar Hepatocellular Carcinoma at the High Specialty Hospital of Veracruz, Mexico." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 02 (2023): 209–11. https://doi.org/10.5281/zenodo.7632028.

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Fibrolamellar hepatocellular carcinoma is a primary hepatic malignancy, primarily affecting adolescents and young adults without underlying liver disease. We present the case of a 22-year-old male farmer who presents burning pain in the epigastrium with an intensity of 2/10 on the VAS scale, on palpation with the presence of a tumor in the right hypochondrium with ultrasound of the liver and bile ducts with evidence of liver mass in the segment VIII, in addition to exploratory laparoscopy with the discovery of multiple implants in 70% of the liver surface. In the histopathological analysis wit

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16

Ulmer, Scott C. "Hepatocellular carcinoma." Postgraduate Medicine 107, no. 5 (2000): 117–24. http://dx.doi.org/10.3810/pgm.2000.5.1.1062.

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17

OBARA, Yuki, Miho HAGIOITA, Michihiro SHIMIZU, Kohji YOSHIDA, and Shunichi SASOU. "Hepatocellular carcinoma." Journal of the Japanese Society of Clinical Cytology 57, no. 5 (2018): 259–66. http://dx.doi.org/10.5795/jjscc.57.259.

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18

Shirato, Kazuhito, Manabu Morimoto, Naohiko Tomita, et al. "Hepatocellular Carcinoma." Journal of Ultrasound in Medicine 21, no. 9 (2002): 1015–22. http://dx.doi.org/10.7863/jum.2002.21.9.1015.

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19

Kim, Kyoung Won, Byung Ihn Choi, Seong Ho Park, et al. "Hepatocellular Carcinoma." Journal of Ultrasound in Medicine 22, no. 9 (2003): 887–96. http://dx.doi.org/10.7863/jum.2003.22.9.887.

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20

Gonzalez, Karen B., and Misty Woodall. "HEPATOCELLULAR CARCINOMA." Nursing Clinics of North America 36, no. 3 (2001): 593–602. http://dx.doi.org/10.1016/s0029-6465(22)02581-6.

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21

Parikh, PM, R. Bhagwat, G. Biswas, and L. Goyal. "Hepatocellular Carcinoma." Indian Journal of Medical and Paediatric Oncology 26, no. 04 (2005): 43–57. http://dx.doi.org/10.1055/s-0041-1733134.

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22

Rehman, Khalil ur, Dr Muhammad Samiullah, Sidra Sharif, and Saira Farhat. "HEPATOCELLULAR CARCINOMA." Professional Medical Journal 23, no. 02 (2016): 209–12. http://dx.doi.org/10.29309/tpmj/2016.23.02.1072.

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Background: Hepatocellular carcinoma (HCC) also known as malignanthepatoma, accounts for most of the liver cancers. Alpha fetoprotein (AFP) has been undoubtedlywidely used as a marker for the detection and monitoring of HCC. This study aimed to find thecorrelation of serum alpha fetoprotein and tumor size in HCC in the tertiary care hospital. StudyDesign: This cross sectional descriptive study. Setting: Pathology Department of Allama IqbalMedical College, Lahore (AIMC). Materials and Methods: The study was carried out on 45HCC patients (13 females and 32 males) came to Jinnah Hospital Lahore.

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23

Fahim, Amin, Mohammad Ahmed Azmi, Muhammad Hanif, and Anila Qureshi. "HEPATOCELLULAR CARCINOMA." Professional Medical Journal 23, no. 04 (2016): 415–21. http://dx.doi.org/10.29309/tpmj/2016.23.04.1499.

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Objectives: To determine the expression of miR-92-1 in HCC patients and correlatethem with clinicopathological data. Study Design: A Cross sectional study. Place of Study:Samples were collected from Jinnah Postgraduate Medical Center Karachi, Civil HospitalKarachi and Asian Institute of Medical Sciences Hyderabad. Duration of Study: January2014 to December 2014. Materials and Methods: 150 patients of hepatocellular carcinomawere divided into two groups on the basis of etiologic agent. HCC patients with chronic viralhepatitis B were labeled as group-I, whereas those with chronic viral hepatitis

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24

Kalhoro, Muhammad Amjad, Irfan Murtaza Shahwani, Mashooque Ali Dasti, Syed Zulfiquar Ali Shah, Faisal Shahab, and Zulfiqar Ali Qutrio Baloch. "HEPATOCELLULAR CARCINOMA;." Professional Medical Journal 21, no. 06 (2014): 1222–26. http://dx.doi.org/10.29309/tpmj/2014.21.06.2671.

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Objective: To determine the frequency of hepatocellular carcinoma in different Child-Pugh classes based on Alfa fetoprotein level. Study design: Case series study. Period: Six months Setting: Medical Unit-I of Liaquat University Hospital, Hyderabad Sindh Pakistan. Patients & Methods: A total of 100 patients admitted (inpatients) in Medical Unit I with the diagnosis of cirrhosis were enrolled in the study. Patients with cirrhosis of liver (more than six month duration) of either gender were included. If patients had metastatic lesion of the liver, liver abscess, or acute liver failure then

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25

AMER, WASIM, MUHAMMAD ASHRAF MAJROOH, and MUHAMMAD AKRAM. "HEPATOCELLULAR CARCINOMA." Professional Medical Journal 16, no. 03 (2009): 364–69. http://dx.doi.org/10.29309/tpmj/2009.16.03.2793.

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Introduction: Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world.Characteristics of our population suffering from HCC are not known, this study aims to present epidemiological, clinical and laboratorycharacteristics of HCC patients..Design: A retrospective study. Setting: At Jinnah hospital, Lahore. Period: 36 months. Material & m e t h o dsHCC was diagnosed according to the guide lines given by EASL-2000. The data was later analyzed by SPSS13. Results. A total of 34 patientswere included in the study. Majority patients were male 21(80%) and

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26

Blendis, Laurie, and Morris Sherman. "Hepatocellular Carcinoma." American Journal of Cancer 3, no. 6 (2004): 349–68. http://dx.doi.org/10.2165/00024669-200403060-00003.

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27

DI BISCEGLIE, ADRIAN M. "Hepatocellular Carcinoma." Annals of Internal Medicine 108, no. 3 (1988): 390. http://dx.doi.org/10.7326/0003-4819-108-3-390.

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28

Giovannini, M., D. Elias, G. Monges, J. L. Raoul, and P. Rougier. "Hepatocellular carcinoma." British Journal of Cancer 84, s2 (2001): 74–77. http://dx.doi.org/10.1054/bjoc.2001.1769.

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29

Bergsland, Emily K., and Alan P. Venook. "Hepatocellular carcinoma." Current Opinion in Oncology 12, no. 4 (2000): 357–61. http://dx.doi.org/10.1097/00001622-200007000-00013.

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30

Ohtomo, Kuni, Yuji Itai, Yujiro Matuoka, et al. "Hepatocellular Carcinoma." Journal of Computer Assisted Tomography 14, no. 4 (1990): 650–52. http://dx.doi.org/10.1097/00004728-199007000-00026.

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31

El-Serag, Hashem B. "Hepatocellular Carcinoma." New England Journal of Medicine 365, no. 12 (2011): 1118–27. http://dx.doi.org/10.1056/nejmra1001683.

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32

Villanueva, Augusto. "Hepatocellular Carcinoma." New England Journal of Medicine 380, no. 15 (2019): 1450–62. http://dx.doi.org/10.1056/nejmra1713263.

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33

Hesketh, Richard L., Andrew X. Zhu, and Rahmi Oklu. "Hepatocellular Carcinoma." American Journal of Clinical Oncology 38, no. 4 (2015): 431–36. http://dx.doi.org/10.1097/coc.0000000000000123.

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34

Smith, C. Scott, and Douglas S. Paauw. "Hepatocellular carcinoma." Postgraduate Medicine 94, no. 8 (1993): 71–74. http://dx.doi.org/10.1080/00325481.1993.11945770.

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35

Mitchell, Kisha A. "Hepatocellular Carcinoma." Journal of Clinical Gastroenterology 47 (July 2013): S20—S26. http://dx.doi.org/10.1097/mcg.0b013e318291f237.

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36

Stein, Stacey M. "Hepatocellular Carcinoma." Journal of Clinical Gastroenterology 47 (July 2013): S47—S49. http://dx.doi.org/10.1097/mcg.0b013e3182932e6f.

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37

Pinato, David J., Alessia Dalla Pria, Rohini Sharma, and Mark Bower. "Hepatocellular carcinoma." AIDS 31, no. 5 (2017): 603–11. http://dx.doi.org/10.1097/qad.0000000000001422.

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38

Choi, Byung Ihn, Ah Young Kim, Jae Young Lee, et al. "Hepatocellular Carcinoma." Journal of Ultrasound in Medicine 21, no. 1 (2002): 77–84. http://dx.doi.org/10.7863/jum.2002.21.1.77.

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39

Macdonald, Graeme A. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 13, no. 3 (1997): 257–62. http://dx.doi.org/10.1097/00001574-199705000-00012.

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40

Macdonald, Graeme A. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 14, no. 3 (1998): 250–55. http://dx.doi.org/10.1097/00001574-199805000-00011.

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41

Macdonald, Graeme A. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 15, no. 3 (1999): 253–59. http://dx.doi.org/10.1097/00001574-199905000-00011.

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42

Edwards, John T., and Graeme A. Macdonald. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 16, no. 3 (2000): 275–81. http://dx.doi.org/10.1097/00001574-200005000-00011.

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43

Chokshi, Manish M., and Jorge A. Marrero. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 17, no. 3 (2001): 276–80. http://dx.doi.org/10.1097/00001574-200105000-00011.

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44

Huang, Mary Ann, and Jorge A. Marrero. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 18, no. 3 (2002): 345–50. http://dx.doi.org/10.1097/00001574-200205000-00008.

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Marrero, Jorge A. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 19, no. 3 (2003): 243–49. http://dx.doi.org/10.1097/00001574-200305000-00007.

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46

Lopez, Luis J., and Jorge A. Marrero. "Hepatocellular carcinoma." Current Opinion in Gastroenterology 20, no. 3 (2004): 248–53. http://dx.doi.org/10.1097/00001574-200405000-00009.

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47

Marrero, Jorge A. "Hepatocellular carcinoma." Current Opinion in Internal Medicine 2, no. 3 (2003): 222–28. http://dx.doi.org/10.1097/00132980-200302030-00002.

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48

Scheirhauer, W., and M. Hejna. "Hepatocellular Carcinoma." Oncology Research and Treatment 18, no. 4 (1995): 327–32. http://dx.doi.org/10.1159/000218612.

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49

Buendia, M. A., and C. Neuveut. "Hepatocellular Carcinoma." Cold Spring Harbor Perspectives in Medicine 5, no. 2 (2015): a021444. http://dx.doi.org/10.1101/cshperspect.a021444.

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50

Falkson, G., S. Lipsitz, E. Borden, I. Simson, and D. Haller. "Hepatocellular Carcinoma." American Journal of Clinical Oncology 18, no. 4 (1995): 287–92. http://dx.doi.org/10.1097/00000421-199508000-00003.

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