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Journal articles on the topic 'Hepatoprotective agent'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Meshack, Sanjana, and Suchita Gupta. "A Review of Plants with Remarkable Hepatoprotective Activity." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 194–202. http://dx.doi.org/10.22270/jddt.v12i1.5283.

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Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection .Preventive and therapeutic activity of plants as a hepatoprotective agent is a topic of interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazide etc. increase the serum biomarkers of liver where ALT is more specific than AST in detecting liver injury. Drug-induced liver injury (DILI) wherein more than 900 drugs have been implicated in causing liver injury. Plant phenolics include simple phenols, ph

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2

Rizky, Muthiana, Herri S. Sastramihardja, and Ismet Muchtar Nur. "Solanumnigrum L. as a Hepatoprotective Agent." Althea Medical Journal 2, no. 1 (2015): 63–67. http://dx.doi.org/10.15850/amj.v2n1.433.

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3

Tanaka, Yoshitaka. "A new hepatoprotective agent, SY-640." Japanese Journal of Pharmacology 67 (1995): 46. http://dx.doi.org/10.1016/s0021-5198(19)46154-4.

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4

Vadivu, Rajendran, A. Jerad Suresh, K. Girinath, P. Boopathi Kannan, R. Vimala, and N. M. Satish Kumar. "Evaluation of Hepatoprotective and In-vitro Cytotoxic Activity of Leaves of Premna serratifolia Linn." Journal of Scientific Research 1, no. 1 (2008): 145–52. http://dx.doi.org/10.3329/jsr.v1i1.1046.

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Premna serratifolia is used by the traditional practitioners as cardiotonic, antibiotic, anti-coagulant, stomachic, carminative, hepatoprotective, antitumor etc. The present study aims in the evaluation of hepatoprotective and in-vitro cytotoxic activity of alcoholic extract of leaves of Premna serratifolia Linn. Hepatoprotective activity is studied by carbon tetrachloride induced hepato-toxicity in rats and the in-vitro cytotoxic activity is carried out by tryphane blue exclusion method using EAC cell lines. The degree of protection in hepatoprotective activity has been measured by using bioc

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ZHAO, X., A. MONTET та J. MONTET. "β muricholic acid: a new hepatoprotective agent☆". Journal of Nutritional Biochemistry 4, № 2 (1993): 105–12. http://dx.doi.org/10.1016/0955-2863(93)90008-k.

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Anand, K., B. Singh, D. Chand, and B. Chandan. "An Evaluation ofLawsonia albaExtract as Hepatoprotective Agent." Planta Medica 58, no. 01 (1992): 22–25. http://dx.doi.org/10.1055/s-2006-961382.

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Gomes, A., M. Das, P. Sur, et al. "Glycosmis arborea extract as a hepatoprotective agent." Phytotherapy Research 17, no. 5 (2003): 571–74. http://dx.doi.org/10.1002/ptr.1191.

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Heidari, Reza, Mohammad Reza Arabnezhad, Mohammad Mehdi Ommati, Negar Azarpira, Elham Ghodsimanesh, and Hossein Niknahad. "Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity." Pharmaceutical Sciences 25, no. 1 (2019): 1–10. http://dx.doi.org/10.15171/ps.2019.1.

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Background: The xenobiotics-induced liver injury is a clinical complication. Hence, finding new hepatoprotective strategies has clinical value. Oxidative stress and its subsequent complications are major mechanisms involved in xenobiotics-induced hepatotoxicity. Boldine is one of the most potent antioxidant molecules widely investigated for its protective properties in different experimental models. In the current study, the hepatoprotective properties of boldine and its potential mechanisms of hepatoprotection have been investigated. Methods: Rats received thioacetamide (TAA; 200 mg/kg, i.p)

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Damle, Mrinalini C., Sachin V. Tembhurne, and Swapnil R. Todkar. "Evaluation of Hepatoprotective Activity of Hydroalcoholic Extract of Onion Peels Containing Protocatechuic Acid." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 82–88. http://dx.doi.org/10.22270/jddt.v9i4.2982.

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India is the second largest country for cultivation of onion. 19.90% of onion is cultivated in India. Onion that is Allium cepa family Amaryllidaceae used in daily diet for taste. Onions also have number of medicinal properties, such as hepatoprotection, anticancer, antifungal, antioxidant, antiulcer, anti-agging, anti-inflammatory, anticancer etc.[1-2] The dried scales or peels of onion also have the same medicinal constituents with same activity as raw onions. The onion peels contains flavonoids, such as anthocyanins, flavones (qurcertin and its derivatives), ferulic, Gallic, protocatechuic

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Lubis, Meiva Amelia, Aminah Dalimunthe, Panal Sitorus, and Denny Satria. "Hepatoprotective effects of ethanol extract of mobe leaves/eeml (artocarpus lacucha buch-ham.) against carbon tetrachloride induced hepatotoxicity in rats." International Journal of Ecophysiology 6, no. 2 (2024): 42–48. http://dx.doi.org/10.32734/ijoep.v6i2.17505.

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This study evaluates the protective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) on ALT, AST, and bilirubin levels in rats induced with carbon tetrachloride (CCl4) on Liver. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg BW of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agen

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Saeed, M., D. Babazadeh, M. Arif, et al. "Silymarin: a potent hepatoprotective agent in poultry industry." World's Poultry Science Journal 73, no. 3 (2017): 483–92. http://dx.doi.org/10.1017/s0043933917000538.

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12

Bautista-Avila, Mirandeli, Eduardo Madrigal-SantillÃ¡n, Angel Morales-GonzÃ¡lez, et al. "AN ALTERNATIVE HEPATOPROTECTIVE AND ANTIOXIDANT AGENT: THE GERANIUM." African Journal of Traditional, Complementary and Alternative Medicines 12, no. 4 (2015): 96–105. http://dx.doi.org/10.21010/ajtcam.v12i4.15.

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The Geranium genus is taxonomically classified within the family Geraniaceae Juss, which includes 5-11 genera and nearly 750 species in total. The best-known genera of this family are Geranium, consisting largely of wild plants, and Pelargonium, consisting largely of ornamental plants. Traditional uses include as an antiseptic in wounds and as an antipyretic by infusion of the plant. Currently, eight different species of geraniums belonging to the family Geraniaceae have been identified in Hidalgo State in Central Mexico, and no chemical or pharmacological studies have been carried out in any

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13

Prasad Sahu, Bishnu, Manish Kumar Gautam, Biplab Kumar Dey, and Bibekananda Meher. "Assessment of Hepatoprotective Potential of Dendrobium bicameratum, a Bryophyte from Eastern Ghats, Odisha." Cuestiones de Fisioterapia 54, no. 4 (2025): 5506–10. https://doi.org/10.48047/9emmpf45.

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An investigation was conducted to assess the hepatoprotective potential of hydroalcoholic andaqueous extracts of Dendrobium bicameratum in Wistar rats with carbon tetrachloride (CCl4)-induced hepaticdamage. The extent of liver injury was evaluated by measuring serum biomarkers, including SGOT, SGPT,total albumin, total protein, IL-1β, IL-6, and TNF-α. Administration of hydroalcoholic (HADBM) and aqueous(ADBM) extracts at 200 mg/kg, as well as silymarin (100 mg/kg), demonstrated significant (P < 0.05)hepatoprotective effects by reducing the levels of serum hepatoprotective and inflammatory m

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Wang, Anqi, Qianyu Liu, Yang Ye, Yitao Wang, and Ligen Lin. "Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells." Food & Function 6, no. 9 (2015): 3013–21. http://dx.doi.org/10.1039/c5fo00573f.

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15

Dr. Divya Singh, Dr Divya Singh, Hina Afaq Hina Afaq, Abdul Hameed Abdul Hameed, and Yash Srivastav Yash Srivastav. "Pre-Clinical Evaluation of Therapeutic Potential of Prunetin as a Hepatoprotective Agent." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 16171–1640. https://doi.org/10.35629/4494-100316171640.

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The term “hepatoprotective” describes a substance’s capacity to shield the liver from harm. This may entail lowering inflammation, encouraging liver cell regeneration, or limiting damage from toxins. The current study's findings indicated that prunetin had phenolic content, proteins, amino acids, sterols, glycosides, saponins, flavonoids, alkaloids, and carbs. Of all the flavonoids, prunetin's hepatoprotective action is caused by glycosides and phenolic compounds. To determine the appropriate dosage of the non-toxic prunetin, additional acute toxicity research was conducted. According to an ac

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Lubis, Meiva Amelia, Aminah Dalimunthe, Panal Sitorus, Denny Satria, and Arga Lubis. "Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride." Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan 17, no. 3 (2025): 452–64. https://doi.org/10.35960/vm.v17i3.1490.

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This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in

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17

Dr., Divya Sing1 Hina Afaq2 Abdul Hameed3* Yash Srivastav4. "Hepatoprotective Abilities of Flavonoids and the Development and Detection of Hepatic diseases (Liver disease): A Systematic Overview." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1801–9. https://doi.org/10.5281/zenodo.14442532.

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Any ailment that affects your liver is referred to as liver disease. Although the causes of these disorders may vary, they can all harm your liver and impair its ability to operate. Your liver is an essential organ that carries out hundreds of metabolic, energy-storage, and waste-filtering functions. It facilitates food digestion, energy conversion, and storage until needed. Additionally, it aids in removing harmful toxins from your circulation. Liver-protective, antioxidant, and anti-inflammatory qualities are significant dietary components, such as flavonoid consumption, in enhancing liver h

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18

Indrajaya, Putra, Mudawamah Mudawamah, Umi Kalsum, Adinda Rizky Trisakti, and Aldin Akbar Rahmatullah. "Amelioration of Cigarette Smoke-Induced Hepatic Injury by Green Tea (Camellia sinensis) Extract: Evidence from SGOT and SGPT Biomarkers in a Murine Model." Journal of Basic Medical Veterinary 14, no. 1 (2025): 79–88. https://doi.org/10.20473/jbmv.v14i1.72636.

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This study investigated the hepatoprotective effects of green tea extract (GTE) against cigarette smoke-induced liver damage in mice. Twenty-five male mice (Mus musculus) were divided into five groups: negative control (C-), positive control exposed to cigarette smoke (C+), and three experimental groups exposed to cigarette smoke and treated with different doses of GTE: 20 mg/kg BW (T1), 40 mg/kg BW (T2), and 60 mg/kg BW (T3). Following 36 days of treatment, serum SGOT and SGPT levels were measured as biomarkers of hepatocellular injury. Results showed significant elevation of both enzymes in

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Al-Tameemi, Zahraa Salam, Hany A. Al-Hussaniy, Ali Mahmoud Al-Samydai, Meena Akeel Naji, Fuaad I. Iraqi, and Fatima A. Naji. "A detailed analysis of Spirulina's therapeutic properties in liver protection, oxidative stress reduction, and cancer management." Current Issues in Pharmacy and Medical Sciences 38, no. 1 (2025): 27–30. https://doi.org/10.12923/cipms-2025-0004.

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Spirulina, a cyanobacterium recognized for its nutritional benefits, has recently garnered attention for its potential therapeutic properties. This review aims to comprehensively consolidate current knowledge on the pharmacological attributes of Spirulina species, focusing on their hepatoprotective, antioxidant and anticancer effects. An exhaustive literature search was conducted, collating data from empirical studies, clinical trials and reviews pertaining to the pharmacological effects of Spirulina. Spirulina exhibits significant hepatoprotective activities, evidenced by its ability to mitig

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20

Barlas, A. M., M. Sadic, H. I. Atilgan, et al. "Melatonin: a hepatoprotective agent against radioiodine toxicity in rats." Bratislava Medical Journal 118, no. 02 (2017): 95–100. http://dx.doi.org/10.4149/bll_2017_020.

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21

HASE, Koji, Shigetoshi KADOTA, Purusotam BASNET, Jianxin LI, Shuichi TAKAMURA, and Tsuneo NAMBA. "Tetrahydroswertianolin: a Potent Hepatoprotective Agent from Swertia japonica MAKINO." CHEMICAL & PHARMACEUTICAL BULLETIN 45, no. 3 (1997): 567–69. http://dx.doi.org/10.1248/cpb.45.567.

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22

Meng, Meng, Rui Zhang, Ran Han, Yu Kong, Ruhua Wang, and Lihua Hou. "The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/d-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways." Food & Function 12, no. 5 (2021): 1973–82. http://dx.doi.org/10.1039/d0fo03327h.

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23

Saxena, Mohit, Uzma Faridi, S. K. Srivastava, et al. "A Cytotoxic and Hepatoprotective Agent from Withania somnifera and Biological evaluation of its Ester Derivatives." Natural Product Communications 2, no. 7 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200714.

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Detailed chemical investigation of Withania somnifera roots resulted in the isolation and identification of a cytotoxic and hepatoprotective agent, palmitic acid (1), which was converted to eight semi-synthetic ester derivatives 2–9. t-Butyl palmitate (8) and amyl palmitate (9) were 4–6 times more active than 1 against adherent and suspension colon cancer cell lines. Interestingly, palmitic acid (1) and its ester derivatives 2–9 also showed hepatoprotective activity which is being reported for the first time.

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24

Lohvinenko, N., V. Shvets, G. Berest, et al. "Prospects for the use of sulfur-containing pteridines in toxic liver damage." Regulatory Mechanisms in Biosystems 15, no. 2 (2024): 374–81. http://dx.doi.org/10.15421/022453.

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The presented material describes the results of the purposeful search for the novel hepatoprotective agents among synthetic sulfur-containing pteridines. The studied compounds were obtained using previously described synthetic procedures. SwissADME and ProTox-II services, as well as a docking study were used to predict the compounds` pharmacokinetics, drug-likeness and toxicity. The effects of sulfur-containing pteridines on lipid peroxidation in vitro and GSH/GSSG levels in vivo were studied for evaluation of their hepatoprotective potential. In silico procedures allowed us to exclude the com

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25

Okoro, E. O. "Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats." Journal of Applied Sciences and Environmental Management 28, no. 3 (2024): 691–98. http://dx.doi.org/10.4314/jasem.v28i3.9.

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Hepatoprotection or antihepatotoxicity is the ability of an agent or chemical to prevent damage to the liver. These hepatoprotective agents mitigate the liver injury caused by the hepatotoxic agents. Therefore, the objective of this paper was to investigate the hepatoprotective effect of ethanolic extract of Cnestis ferruginea roots on carbon tetrachloride (CCl4)-induced liver damage in male rats using appropriate standard methods. A single dose of CCl4 administration significantly (p<0.05) increased the levels of ALT and AST in the positive control group, compared to the negative control g

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Lin, Tzu-Hsiang, Lean-Teik Ng, Feng-Lin Yen, and Chun-Ching Lin. "Hepatoprotective Effects of Chai-Hu-Ching-Kan-Tang on Acetaminophen-Induced Acute Liver Injury in Rats." American Journal of Chinese Medicine 35, no. 01 (2007): 69–79. http://dx.doi.org/10.1142/s0192415x07004631.

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Chai-Hu-Ching-Kan-Tang (CHCKT) is one of the traditional Chinese medicine prescriptions commonly used to treat liver diseases. In this study, we evaluated the hepatoprotective effects of aqueous CHCKT extract at various concentrations (125, 250 and 500 mg/kg body weight) on acetaminophen (APAP)-induced acute liver injury in rats. Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups. CHCKT also significantly decreased the level of lipid peroxides and increased the

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27

Chen, Li-Chun, Shi-Yu Zhang, Yu Zi, Hui-Min Zhao, Hong-Yu Wang, and Yue Zhang. "Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect." Food & Function 11, no. 11 (2020): 9495–502. http://dx.doi.org/10.1039/d0fo01658f.

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28

Bautista, M., E. Madrigal-Santillan, A. Morales-Gonzalez, et al. "An alternative hepatoprotective and antioxidant agent: the Geranium." African Journal of Traditional, Complementary and Alternative Medicines 12, no. 4 (2015): 96. http://dx.doi.org/10.4314/ajtcam.v12i4.15.

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29

Hartwig, Wolfgang, and Liborius Born. "Diastereoselective and enantioselective total synthesis of the hepatoprotective agent clausenamide." Journal of Organic Chemistry 52, no. 19 (1987): 4352–58. http://dx.doi.org/10.1021/jo00228a037.

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Soni, Madhusudan G., and Harihara M. Mehendale. "Hepatoprotective agent (+)-cyanidanol increases the synthetic phase of hepatocellular regeneration." International Journal of Biochemistry 23, no. 12 (1991): 1369–73. http://dx.doi.org/10.1016/0020-711x(91)90277-t.

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31

Chamulitrat, Walee, Jürgen Burhenne, Tobias Rehlen, Anita Pathil, and Wolfgang Stremmel. "Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent." Hepatology 50, no. 1 (2009): 143–54. http://dx.doi.org/10.1002/hep.22955.

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Ruiz de Porras, Vicenç, Mariona Figols, Albert Font, and Eva Pardina. "Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury." Life Sciences 332 (November 2023): 122119. http://dx.doi.org/10.1016/j.lfs.2023.122119.

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Sabini, Jasmine Harumi, and Kris Herawan Timotius. "Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)." Current Issues in Molecular Biology 47, no. 3 (2025): 159. https://doi.org/10.3390/cimb47030159.

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Fat accumulation is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). Given the intimidating nature of its treatment, curcumin (CUR) emerges as a potential therapeutic agent due to its proven effectiveness in managing MASLD. This review aimed to evaluate previous reports on the hepatoprotective and fat-accumulation-reductive effects of CUR administration in preventing or treating MASLD. CUR administration can modulate serum liver enzymes and lipid profiles. The fat accumulation of MASLD is the primary cause of oxidative stress and inflammation. By reducing fat a

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Handayani, Sri, Dina Aprilia, Khoirun Nisa, et al. "A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel." Indonesian Journal of Cancer Chemoprevention 12, no. 3 (2022): 170. http://dx.doi.org/10.14499/indonesianjcanchemoprev12iss3pp170-179.

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Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in s

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Wibowo, Much Ilham Novalisa Aji, Nur Aeni, Zidna Mazayatul Huda, and Nunuk Aries Nurulita. "The Hepatoprotective Effect of Ethanol Extract of Syzygium campanulatum (Korth) and Syzygium aromaticum (L) Leaf on Male Wistar Rat (Rattus Norvegicus) was Induced by Paracetamol." JURNAL ILMU KEFARMASIAN INDONESIA 15, no. 2 (2017): 196. http://dx.doi.org/10.35814/jifi.v15i2.517.

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Syzygium campanulatum and Syzygium aromaticum contains antioxidant components suchas flavonoids, phenolic, and terpenoids. May have hepatoprotective properties in reducing SGPT and SGOT activity. This research wants to determine the potency of hepatoprotective of ethanolic extract of Syzygium campanulatum (Korth) and Syzygium aromaticum leaf compared with curcuma tablets. This research uses 24 male Wistar rats divided into 6 groups: I, II, III (as a normal, induction, and compared control), group IV, V, VI were treated 105, 210, and 420 mg/kg BW respectively. The study was conducted for 9 days

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Athokpam, Rojini, Meenakshi Bawari, and Manabendra Dutta Choudhury. "HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF OXALIS DEBILIS KUNTH AGAINST CCL4 - INDUCED LIVER DAMAGE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 231. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19100.

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Objective: To evaluate the hepatoprotective activity of aqueous extract of Oxalis debilis Kunth in carbon tetrachloride (CCl4)-induced hepatotoxicity in Swiss albino mice.Methods: Hepatotoxicity was induced by CCl4 30% in olive oil (1 ml/kg intraperitoneally). Mice were treated with aqueous extract of O. debilis at doses of 250 and 500 mg/kg body weight orally for 14 days. There were two groups, pre-treatment (once daily for 14 days before CCl4 intoxication) and post-treatment (2, 6, 24, and 48 hrs after CCl4 intoxication). The observed effects were compared with a known hepatoprotective agent

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Al-Dosari, Mohammed S. "The Effectiveness of Ethanolic Extract ofAmaranthus tricolorL.: A Natural Hepatoprotective Agent." American Journal of Chinese Medicine 38, no. 06 (2010): 1051–64. http://dx.doi.org/10.1142/s0192415x10008469.

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The ethanolic extract of Amaranthus tricolor L. (ATE) leaves was tested for its efficacy against CCl4-induced liver toxicity in rats. The hepatoprotective activity of ATE was evaluated via measuring various liver toxicity parameters, the lipid profile, and a histopathological evaluation. A sleeping time determination study and an acute toxicity test were performed in mice. The results clearly showed that oral administration of ATE for three weeks significantly reduced the elevated levels of serum GOT, GPT, GGT, ALP, bilirubin, cholesterol, LDL, VLDL, TG, and MDA induced by CCl4. Moreover, ATE

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Akhmadiev, Nail Salavatovich, Albina Midkhatovna Galimova, Vnira Rakhimovna Akhmetova, et al. "Molecular Docking and Preclinical Study of Five-MemberedS,S-Palladaheterocycle as Hepatoprotective Agent." Advanced Pharmaceutical Bulletin 9, no. 4 (2019): 674–84. http://dx.doi.org/10.15171/apb.2019.079.

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Purpose: In order to investigate mechanisms underlying the hepatoprotective action of S,Spalladaheterocycle,inhibition of cytochromes P450 has been modeled by molecular dockingof four palladaheterocycle stereoisomers to the active sites of an enzymatic oxidase system. Toobtain a deeper insight into biochemical aspects providing a basis for the therapeutic effects offive-membered palladacycles (as mixture of stereoisomers), a number of preclinical trials hasbeen conductedMethods: 2D and 3D structures of palladaheterocycle stereoisomers were obtained viaconverting into SDF files by means of soft

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Thiruppathi, M. *. Vijay Nagendiran P. Thirupathy kumaresan P. Natarajan P. "HEPATOPROTECTIVE ACTIVITY OF VARIOUS EXTRACTS OF CADABA FRUTICOSA AGAINST PARACETAMOL-INDUCED LIVER INJURY IN RATS." Journal of Pharma Research 8, no. 8 (2019): 595–602. https://doi.org/10.5281/zenodo.3374099.

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<strong><em>ABSTRACT</em></strong> <strong><em>H</em></strong><em>erbal medicine has long been used for the prevention and treatment of a wide range of medical conditions, as well as for general health enhancement.</em><em> Liver injury is one of the major health problems in human which sometimes may lead to even death. Herbal products may be the most excellent source of remedies for the treatment of liver diseases. Thus the innovation of a potential therapeutic agent for the safety of the liver from the hepatotoxins will provide a useful way for the prevention of these liver-related illnesses

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Pavlov, A. I., A. S. Balabanov, V. E. Bakirova, et al. "Evaluation of the efficacy of a hepatoprotector for the treatment of toxic (drug-induced) liver injury." Meditsinskiy sovet = Medical Council, no. 8 (June 18, 2025): 126–33. https://doi.org/10.21518/ms2025-232.

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Introduction. Toxic liver injury is widespread among patients, especially those with comorbidities and polypharmacy. The non-specific clinical manifestations and significant variability in liver and systemic changes complicate timely diagnosis and initiation of treatment.Aim. To evaluate the effectiveness of therapy for toxic (drug-induced) liver injury using a hepatoprotective agent containing inosine, meglumine, methionine, nicotinamide and succinic acid.Materials and methods. A total of 178 patients (152 men, 26 women) with confirmed drug-induced liver injury were examined. The main group (

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Akhtar, Muhammad Shoaib, Aziz-Ur Rehman, Haroon Arshad, et al. "In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats." Dose-Response 19, no. 1 (2021): 155932582199695. http://dx.doi.org/10.1177/1559325821996955.

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The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. The research work was planned to study the therapeutic potential of some newly synthesized chalcones against 4-acetaminophenol induced hepatotoxicity in rats. Male albino rats (N = 30) were divided into 6 groups of 5 animals each i.e. group I; Toxic control (4-acetaminophenol), group II; normal control (Normal saline), group III; Positive control (silymarin; 50 mg/kg bw) and groups IV-VI (test groups) treated with 3 chalcone analogues i-e 3a, 3f & 3 g (100, 150, 150 m

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Pradeep, Kannampalli, Chandrasekaran Victor Raj Mohan, Kuppannan Gobianand, and Sivanesan Karthikeyan. "Silymarin: An Effective Hepatoprotective Agent Against Diethylnitrosamine-Induced Hepatotoxicity in Rats." Pharmaceutical Biology 45, no. 9 (2007): 707–14. http://dx.doi.org/10.1080/13880200701575254.

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HASE, K., S. KADOTA, P. BASNET, J. LI, S. TAKAMURA, and T. NAMBA. "ChemInform Abstract: Tetrahydroswertianolin: A Potent Hepatoprotective Agent from Swertia japonica MAKINO." ChemInform 28, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199738278.

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Galal, S. M., M. K. S. Morsi, M. K. Abd El-Rahman, S. K. Darwish, and M. A. Katry. "Hepatoprotective effect of the unsaponifiable matter from olive, linseed and sesame oils against carbon tetrachloride-induced liver injury in rats." Grasas y Aceites 71, no. 1 (2020): 345. http://dx.doi.org/10.3989/gya.1175182.

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In the present study, the hepatoprotective activity of the unsaponifiable matter (UNSAP) of olive oil, linseed, and sesame oils against CCl4-induced liver toxicity in rats was investigated. In a preliminary antioxidant study, UNSAP showed pronounced DPPH radical scavenging activity (IC50 6.2-10.8 mg/mL). The constituents of UNSAP were determined by GC-MS. The subcutaneous administration of CCl4, caused liver injury. The hepatoprotective effect of UNSAP was comparable to that of α-tocopherol, a standard antioxidant agent. The co-administration of the investigated UNSAP normalized the activities

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Gyawali, Rajendra, Amita Shrestha, Ashma Khanal, et al. "HEPATOPROTECTIVE PROPERTIES OF SELECTED PLANTS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE." Journal of Institute of Science and Technology 22, no. 1 (2017): 147–51. http://dx.doi.org/10.3126/jist.v22i1.17766.

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The hepatoprotective properties of the ethanolic extracts of Punica granatum peels, Crataeva religiosa leaves and Jasminum polyanthrum leaves were evaluated for the paracetamol induced liver toxicity in mice. Antioxidant, cytotoxicity and phytochemical screening were carried out to assure the therapeutic efficacy of these plants. Oral administration of plant extracts for 7 days in mice significantly reduced the impact of paracetamol toxicity on the serum markers of liver damage, aspartate transaminase (AST), alanine transaminase (ALT) and total protein. The extract showed significant hepatopro

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Hussain, Asif. "BIOCHEMICAL AND HISTOPATHOLOGICAL INVESTIGATIONS OF HEPATOPROTECTIVE POTENTIAL OF Phoenix dactylifera AGAINST ISONIAZID INDUCED TOXICITY IN ANIMAL MODEL." Pakistan Journal of Agricultural Sciences 56, no. 02 (2019): 489–93. http://dx.doi.org/10.21162/pakjas/19.6097.

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Phoenix dactylifera (Ajwa khajur) is pharmacologically important plant because of its hepatoprotective, nephroprotective, gastroprotective, antihyperlipidemic and anticancerous properties. In present study, hepatoprotective effect of Phoenix dactylifera was observed in adult albino rabbits. Isoniazid (INH) is a first line antitubercular agent but it has hepatotoxicity causing potential due to the generation of reactive oxygen species on its prolong use. Thirty adult albino rabbits of either sex were used in this study. Hepatoprotective potential of date palm was screened by using its two doses

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Cynthia C and Horne Iona Averal. "Antimicrobial and hepatoprotective effect of ISM Drug in alcohol induced liver damage on Zebrafish larvae." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3134–42. http://dx.doi.org/10.26452/ijrps.v11i3.2426.

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Liver cirrhosis occurs due to the extracellular matrix proteins accumulation which distorts the hepatic structure. The aim of our study is to investigate the antimicrobial and hepatoprotective effect of India Siddha Medicine(ISM) drug in alcohol-induced liver damage on zebrafish larvae. ISM drug, a hepatoprotective agent comprising of 15 herbs offers numerous formulations with advantages of hepatocellular rejuvenation has proven to be the most effective treatment to suppress liver damage. A series of analyses were carried out using alcohol-induced liver damage through herbal-based therapeutic

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Mohd Ali, Norlaily, Hamidah Mohd Yusof, Kamariah Long, et al. "Antioxidant and Hepatoprotective Effect of Aqueous Extract of Germinated and Fermented Mung Bean on Ethanol-Mediated Liver Damage." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/693613.

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Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung bean aqueous extracts were compared. Liver superoxide dismutase (SOD), malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), nitric oxide (NO) levels, and serum biochemical profile such as asp

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Bagheri, Sara, Jamshid Tabeshpour, Hossein Hosseinzadeh, Mahmoud Hashemzaei, and Gholamreza Karimi. "Hepatoprotective effects of quercetin against natural and chemical toxicities: A review." Interdisciplinary Toxicology 13, no. 3 (2020): 77–91. https://doi.org/10.2478/intox-2020-0011.

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Abstract Liver metabolizes and detoxifies xenobiotics and toxicity in this organ can lead to dysfunctionality. Flavonoids such as quercetin (QRC) have been shown to possess protective effects against different liver disorders. This flavonol exerts its hepatoprotective effects via different mechanisms including increase of nuclear factor (erythroid-derived 2)-like 2 protein expression, sirtuin 1, thioredoxin and thioredoxin reductase and decrease in nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and myeloid differentiation primary response gene 88 (MYD88). The aim of the

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Kresnapati, I. Nyoman Bagus Aji, Salsabila Yunita Kurniawan, Novitarini Novitarini, and Baiq Yulia Hasni Pratiwi. "Hepatoprotector Edible Flower in Indonesia: A Review." Jurnal Pijar Mipa 20, no. 3 (2025): 544–53. https://doi.org/10.29303/jpm.v20i3.8983.

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Hepatotoxicity is an agent that causes damage to human liver function, and every year, cases of liver damage are increasing. Agents that cause liver damage, such as drugs (Paracetamol), chemicals, Carbon Tetrachloride (CCL4), cause liver damage, which is characterized by an increase in the liver enzymes Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Giving natural ingredients such as edible flower extracts (hepatoprotectors) can reduce SGOT and SGPT levels in liver damage (Hepatoxicity). Indonesia is a country rich in biodiversity, including edib

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