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Dissertations / Theses on the topic 'Hepatoprotector'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Caballero, Calampa José Antonio Benjamín. "Efecto hepatoprotector de la almendra de semillas de Cucurbita maxima (zapallo macre) en ratas." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/3946.

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Objetivos: El presente estudio tiene por objetivo determinar el efecto hepatoprotector de la almendra de semilla de Cucúrbita máxima, sobre los marcadores del daño hepático en ratas con intoxicación por paracetamol. Materiales y métodos: tipo de estudio analítico, experimental, transversal y prospectivo; se empleó 48 ratas Holtzman machos adultos de 2 meses de edad, con peso de 225 ± 24.7g. Se utilizaron las almendras de semillas de Cucurbita maxima (zapallo macre), la almendra se obtuvo retirando el epispermo y la cutícula que rodea el endospermo de la semilla, obteniéndose la almendra del za

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Carbonel, Villanueva Kelly Nora. "Efecto hepatoprotector del extracto acuoso de Gentianella nitida en un modelo experimental inducido por paracetamol." Master's thesis, Universidad Nacional Mayor de San Marcos, 2017. https://hdl.handle.net/20.500.12672/6445.

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Evalúa el efecto hepatoprotector del extracto acuoso de Gentianella nitida (hercampuri) en un modelo experimental inducido por paracetamol. Para evaluar el efecto de hepatoprotección del extracto de Gentianella nitida se emplea paracetamol como inductor del daño hepático. Se analiza in vitro la capacidad antioxidante (DPPH, ABTS, FRAP), el contenido de fenoles totales y flavonoides del extracto acuoso de Gentianella nitida. En el modelo in vivo se trabaja con 24 ratas Holtzman hembras de 2 meses, formándose 4 grupos (n= 6): grupo control, grupo paracetamol, grupo silimarina y grupo Gentianella

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3

Torres, Montañez Albino Edder Giordano. "Efecto hepatoprotector del zumo de Spondias purpurea “ciruela” variedad roja en ratones inducidos a toxicidad por etanol." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/5052.

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Determina el efecto hepatoprotector del zumo de Spondias purpurea (ciruela) variedad roja en ratones inducidos a toxicidad por Etanol. Es un estudio de tipo analítico, experimental y transversal. Utiliza una muestra de 40 ratones machos albinos (Mus musculus) cepa Balb/c/ CNPB, con un promedio de peso de 30±5 g. Emplea el zumo de fruta de Spondias purpurea (ciruela) por presión manual y colado con un tamiz fino. Los ratones fueron distribuidos de forma aleatoria en cinco grupos (n=8). Se les aplicó los siguientes tratamientos por cincos días, vía peroral: grupo I y II: suero fisiológico; grupo

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4

Sánchez, Torres Carlos Alberto, and Ríos Guillermo Carlos Sotomayor. "Efecto hepatoprotector del zumo de fruta de la opuntia ficus indica (tuna), variedad morada, en ratas con intoxicación hepática inducida por paracetamol." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/4192.

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Introducción: Las enfermedades hepáticas de evolución crónica degenerativa, constituyen una de las causas de morbilidad y mortalidad a nivel mundial. Objetivos: Determinar el efecto hepatoprotector del zumo de fruta del Opuntia ficus indica (tuna) variedad morada, en ratas con intoxicación hepática inducidas por paracetamol. Diseño: analíticos –experimental. Lugar: Centro de Investigación de Bioquímica y Nutrición. Participantes y materiales: se utilizaron 36 ratas machos con un peso de 269 g ±22 g. Intervenciones: el zumo se obtuvo mediante un extractor casero. La inducción fue realizada con

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Lipe, Camero Carolina Rocio. "Efecto hepatoprotector del zumo del fruto de Corryocactus brevistylus (Sanky) en ratones con daño hepático inducido por etanol." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/5220.

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Determina el efecto hepatoprotector del zumo del fruto de Corryocactus brevistylus (Sanky) en ratones con daño hepático inducido por etanol. Utiliza las instalaciones del Centro de Investigación de Bioquímica y Nutrición Alberto Guzmán Barrón de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Realiza un estudio analítico, transversal, prospectivo y experimental. Emplea una muestra de 56 ratones albinos, machos, adultos, y zumo del fruto de Corryocactus brevistylus (Sanky). El fruto del sanky fue recogido del distrito de Puquina, provincia General Sánchez Cerro, región d

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Huamaní, Zavaleta Wendy Nicole, and Carhuancho Jesus Isaias Marx Bejarano. "Efecto hepatoprotector del consumo de Nostoc commune (cushuro) frente al daño inducido por dietas ricas en sacarosa en ratones." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2022. https://hdl.handle.net/20.500.12672/17916.

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Evalua el efecto hepatoprotector del consumo de Nostoc commune (cushuro) frente al daño inducido por dietas ricas en sacarosa en ratones. Diseño de tipo experimental. Se emplearon 28 ratones macho con peso promedio de 30 ± 6,2 g y pulverizado de cushuro. Los animales fueron distribuidos en cuatro grupos recibiendo las siguientes dietas durante 50 días: Grupo I: dieta A (sacarosa 10%), grupo II: dieta B (sacarosa 36,5%), grupo III: dieta C (sacarosa 36,5% + cushuro 1%) y grupo IV: dieta D (sacarosa 36,5% + cushuro 3%). Posteriormente se extrajo el hígado y se realizó los análisis bioquímicos e

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Huamán, Gutiérrez Oscar Gustavo. "Evaluación de la capacidad antioxidante y efecto hepatoprotector del zumo del fruto corryocactus brevistylus, en ratas con intoxicación por paracetamol." Doctoral thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/10717.

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Analiza la capacidad antioxidante y el efecto del zumo del fruto Corryocactus brevistylus (sanky) en el hígado frente a la toxicidad por paracetamol en ratas. Se empleó el zumo y el sobrenadante del zumo del fruto de sanky y 48 ratas machos. La actividad antioxidante del zumo y del sobrenadante del zumo fueron evaluados por la capacidad de reducir al radical DPPH e inhibir la lipoperoxidación en homogenizado de tejido hepático frente al sistema H2O2/FeSO4. Para la evaluación de hepatoprotección los animales fueron distribuidas aleatoriamente en seis grupos (n=8), recibiendo los siguientes trat

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8

Carrión, Bedón Yessenia Elizabeth. "Efecto hepatoprotector del zumo del fruto Solanum betaceum (sacchatomate variedad rojo púrpura) frente al daño hepático inducido por paracetamol en ratones." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2022. https://hdl.handle.net/20.500.12672/17831.

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Las enfermedades hepáticas repercuten negativamente en la salud pública y lideran entre las causas de mortalidad a nivel mundial. El incremento de obesidad y sedentarismo se relacionan con el aumento de estas enfermedades; paralelamente, fármacos como el paracetamol, dañan el hígado por sobredosis pudiendo ser letales. Consumo de alimentos funcionales con antioxidantes podría coadyuvar al tratamiento de hepatopatías. Por ello la presente investigación busca determinar el efecto hepatoprotector del zumo del fruto Solanum betaceum “Sachatomate” (var. rojo púrpura) en ratones intoxicados con

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9

ávila, Daiana Silva de. "Atividades hepato e neuroprotetora do dietil-2-fenil-2-telurofenil vinilfosfonato." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4408.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Despite the growing use of organotellurium compounds in the chemistry and biochemistry field, little is known about the pharmacology of these compounds. The diethyl-2-phenyl-2-tellurophenyl vinylphosphonate (DPTVP) is a vinylic telluride wich shows low toxicity in mice and a high antioxidant activity in vitro. These previous data encoraged us to evaluate the antioxidant potential and the pharmacological benefits that the compound could provide. It was observed that the compound can protect at low concentrations (from 1μM) against t

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Ілюшина, Антоніна Анатоліївна, Наталія Вікторівна Пашковська, Лариса Борисівна Павлович та Ольга Анатоліївна Оленович. "Застосування препарату «Лівергол 140» у хворих на цукровий діабет типу 2". Thesis, Цукровий діабет як міждисциплінарна проблема: стандарти діагностики і лікування з позиції доказовості: Матеріали наук. наук.-практ. конф. з міжнар. уч. – Харків, 16 вер. 2011. – 34, 2011. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/3235.

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Dodd, Charlotte Claire. "The role of glutathione in hepatoprotection." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250328.

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Троцька, Ірина Олександрівна, Ирина Александровна Троцкая та Iryna Oleksandrivna Trotska. "Нові позиції та можливості застосування гепатопротекторів у клінічній практиці". Thesis, Видавництво СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/3788.

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13

Whu, Whu Delia Yolanda. "Actividad energética y hepatoprotectora de las hojas de Baccharis lanceolata (Chilca)." Doctoral thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/3523.

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Introducción: La función de la cadena respiratoria es importante para la homeostasis. Objetivos: Comprobar el efecto energético y hepatoprotector que puede producir el extracto acuoso de Baccharis lanceolata H.B.K. en la cadena respiratoria. Diseño: Experimental. Lugar: Facultades de Farmacia y Bioquímica, Medicina - Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Ratas albinas, hojas de la planta. Intervenciones: En relación al efecto energético se ha evaluado la actividad respiratoria en mitocondria de hígado de rata a través del control respiratorio, actividad de l

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14

Rey, Vidal Oliver Alberto. "Actividad hepatoprotectora de Ananas comusus (piña) en ratas con toxicidad hepática inducida por isoniacida." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2017. https://hdl.handle.net/20.500.12672/6827.

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Determina el efecto hepatoprotector de Ananas comosus (piña) en ratas con intoxicación hepática inducida por isoniacida. Es un estudio transversal experimental. Se empleó una población de 24 ratas Holtzman hembras, separadas aleatoriamente en 4 grupos y administrando por 14 días a cada grupo: A (control dieta y agua), B (isoniacida 50 mg/kg), C (silimarina 200 mg/kg e isoniacida 50 mg/kg) y D (piña 400 mg/kg e isoniacida 50 mg/kg). Se usaron las pruebas no paramétricas de Wilcoxon y Kruskall Wallis. Los resultados demostraron que en el grupo B los niveles de albúmina (4.75 ± 1.37) y proteínas

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Beilke, Lisa D. "Mechanisms of Hepatoprotection in a Murine Model of Bile Acid-Induced Intrahepatic Cholestasis." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194264.

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There are many causes of cholestasis, which results when the flow of bile acids is slowed or stopped. Bile acids are hydrophobic molecules synthesized from cholesterol in the liver, and when present in excess, are cytotoxic to cell membranes. Treatment options for cholestasis are limited, and if left untreated or inadequately treated, many patients will require a liver transplant; thus, underscoring the importance of successfully managing this disease. Activation of nuclear receptors in animal models has been shown to be hepatoprotective during bile acid-induced cholestasis; however, the mecha

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Gauliard, Agnès. "L'aucuboside." Paris 5, 1993. http://www.theses.fr/1993PA05P238.

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Ruiz, Chavez Isaac. "Développement de nouvelles approches thérapeutiques en virologie et hépatologie : Small-Molecule Cyclophilin Inhibitors (SMCypI)." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0041.

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Au sein du laboratoire, par une stratégie de conception de médicaments par la méthode des fragments, nous avons généré une nouvelle famille d'inhibiteurs de cyclophilines, les SMCypI (« Small-Molecule Cyclophilin Inhibitors »), non liée aux autres inhibiteurs de cyclophilines existants. Les cyclophilines sont des protéines cellulaires impliquées dans un grand nombre de processus biologiques. Toutefois, les inhibiteurs de cyclophilines disponibles possèdent de nombreux inconvénients qui rendent leur utilisation clinique difficile. Au cours de ma thèse nous nous sommes intéressés au développemen

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Coulet, Isabelle. "Chimioprévention et chimiothérapie anticancéreuses par les flavonoi͏̈des." Paris 5, 1993. http://www.theses.fr/1993PA05P040.

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Marquet, Florence. "Garcinia kola Heckel." Paris 5, 1996. http://www.theses.fr/1996PA05P189.

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Golicki, Isabelle. "Les propriétés hépatoprotectrices du chardon Marie (Silybum Marianum L. )." Paris 5, 1998. http://www.theses.fr/1998PA05P099.

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Larche, Anne. "Fiches de documentation pratique de cinq plantes hépatotropes : boldo-chardon-marie-chelidoi͏̈ne-radis noir-romarin." Paris 5, 1994. http://www.theses.fr/1994PA05P108.

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Valentão, Patrícia Carla Ribeiro. "Limonete, Hipericão-do-Gerês, Cardo-do-Coalho, Fel-da-Terra : Metodologias de controlo de qualidade com base na fracção fenólica : Estudos de acção antioxidante e hepatoprotectora." Doctoral thesis, Universidade do Porto. Reitoria, 2002. http://hdl.handle.net/10216/9820.

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Dissertação de Doutoramento em Farmacognosia apresentada à Faculdade de Farmácia da Universidade do Porto<br>Neste trabalho foram estudadas quatro espécies medicinais de grande consumo em Portugal: Lippia citriodora (Limonete), Hypericum androsaemum (Hipericão-do-Gerês), Cynara cardunculus (Cardo-do-Coalho) e Centaurium erythraea (Fel-da-Terra).Embora a caracterização química do Limonete e do Fel-da-Terra, definida em Farmacopeias, seja feita através da detecção de compostos terpénicos, foi objectivo deste trabalho propor metodologias para controlo de qualidade de cada uma das quatro espécies,

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Valentão, Patrícia Carla Ribeiro. "Limonete, Hipericão-do-Gerês, Cardo-do-Coalho, Fel-da-Terra : Metodologias de controlo de qualidade com base na fracção fenólica : Estudos de acção antioxidante e hepatoprotectora." Tese, Universidade do Porto. Reitoria, 2002. http://hdl.handle.net/10216/9820.

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Dissertação de Doutoramento em Farmacognosia apresentada à Faculdade de Farmácia da Universidade do Porto<br>Neste trabalho foram estudadas quatro espécies medicinais de grande consumo em Portugal: Lippia citriodora (Limonete), Hypericum androsaemum (Hipericão-do-Gerês), Cynara cardunculus (Cardo-do-Coalho) e Centaurium erythraea (Fel-da-Terra).Embora a caracterização química do Limonete e do Fel-da-Terra, definida em Farmacopeias, seja feita através da detecção de compostos terpénicos, foi objectivo deste trabalho propor metodologias para controlo de qualidade de cada uma das quatro espécies,

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Silva, Marina Alves Coelho. "Atividade hepatoprotetora do extrato hidroalcólico do resíduo agroindustrial de jabuticaba (Myrciaria cauliflora O. Berg), e do extrato etanólico das folhas de fruta-pão (Artocarpus altilis (Parkinson) Fosberg), em camundongos." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4950.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2015-11-26T08:33:48Z No. of bitstreams: 2 Dissertação - Marina alves Coelho Silva - 2015.pdf: 1699881 bytes, checksum: 12e78126a8f1072850d257b422de3155 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-27T07:19:50Z (GMT) No. of bitstreams: 2 Dissertação - Marina alves Coelho Silva - 2015.pdf: 1699881 bytes, checksum: 12e78126a8f1072850d257b422de3155 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306

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Teixeira, Renan Salgado. "Isolamento e identificacao da arctigenina a partir dos frutos da Arctium lappa L. e avaliacao de atividade citotoxica in vitro e hepatoprotetora em ratos." Universidade Federal de Juiz de Fora, 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/1527.

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Panel, Mathieu. "Étude de l'effet de nouveaux ligands de la cyclophiline D sur le pore de transition de perméabilité mitochondrial et de leur effet protecteur." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS490/document.

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Les phénomènes d’ischémie-reperfusion sont rencontrés dans plusieurs situations physiopathologiques. Le seul traitement de l’ischémie repose sur une restauration précoce du flux sanguin. Paradoxalement, la reperfusion génère des lésions supplémentaires, appelées « lésions de reperfusion », dont la mitochondrie est un acteur majeur via l’ouverture du pore de transition de perméabilité mitochondrial (mPTP). L’ouverture du mPTP est principalement modulée par la cyclophiline D (CypD), une protéine de la matrice mitochondriale, dont l’inhibition pharmacologique par la cyclosporine A (CsA) permet de

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Silva, Jucélia Barbosa da. "Análise do perfil químico e investigação da atividade hepatoprotetora in vivo e da citotoxidade e das atividades anti-inflamatória e antibacteriana in vitro de Vernonia condensata Baker (Asteraceae Bencht. & Presl)." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5935.

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Almada, Carine Nunes de. "Atividade antioxidante do extrato etanÃlico de folhas de azeitona da terra (Syzygium Cumini L.) e seu efeito contra estresse induzido por paracetamol." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10229.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Syzygium cumini is a plant originated from India and adapted in Brazil, popularly known as black plum, jambolan and jamun. In this study, the antioxidant and protective activities of ethanolic leaves extract of Syzygium cumini (EE) were evaluated on paracetamol-induced liver damage in mice. The total antioxidant activity was determined by ABTS and DPPH methods and the content of vitamin C, extractable polyphenols, anthocyanins, yellows flavonoids and carotenoids were evaluated by different methods. The toxicity of EE was evaluat

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Carvalho, Paulo Henrique Dias de. "Isolamento e identificação da licochalcona A a partir da Glycyrrhiza inflata e avaliação de suas atividades citotóxica in vitro e hepatoprotetora em modelo de lesão hepática em ratos." Universidade Federal de Juiz de Fora, 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/1840.

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Tôrres, Lucillia Rabelo de Oliveira. "Avaliação físico-química de óleos da amêndoa de pequi (Caryocar brasiliense Camb.) obtidos artesanalmente e por prensagem a frio e sua influência sobre marcadores bioquímicos, oxidativos e inflamatórios de ratos submetidos à toxicidade aguda por tetracloreto de carbono." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-15062016-151226/.

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O óleo da amêndoa de pequi (Caryocar brasiliense Camb.) é considerado um coproduto do fruto, consumido na região do Cerrado, bioma brasileiro. Ele é fundamental para agregar valor e ampliar a utilização deste fruto regional a outros setores produtivos comerciais. Relatos na literatura apontam que o óleo possui capacidade antioxidante e efeitos benéficos sobre doenças inflamatórias, que estão associados à presença de ácidos graxos insaturados e fitoquímicos em sua composição química. Por outro lado, o tetracloreto de carbono (CCl4) é uma potente hepatotoxina, capaz de gerar radicais livres que

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Guedes, Pedro Luiz Rodrigues. "Atividade biológica do condroitim sulfato nos estágios iniciais de colestase extra-hepática." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/4264.

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Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-05-12T13:37:04Z No. of bitstreams: 1 pedroluizrodriguesguedes.pdf: 3448334 bytes, checksum: 3bac263ee478fd60c02c5d6036a0e81e (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-12T15:44:09Z (GMT) No. of bitstreams: 1 pedroluizrodriguesguedes.pdf: 3448334 bytes, checksum: 3bac263ee478fd60c02c5d6036a0e81e (MD5)<br>Made available in DSpace on 2017-05-12T15:44:09Z (GMT). No. of bitstreams: 1 pedroluizrodriguesguedes.pdf: 3448334 bytes, checksum: 3bac263ee478fd60c02c5d60

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Haidara, Mahamane. "Contribution à l'étude de l'activité pharmacologique de Terminalia macroptera Guill.et Perr. (Combretaceae) dans le but de l'élaboration d'un médicament traditionnel amélioré au Mali (Afrique de l'Ouest)." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30027/document.

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En Afrique, la valorisation des pharmacopées traditionnelles constitue bien souvent un moyen d'orienter la recherche vers de nouveaux antipaludéens. Les plantes médicinales antipaludiques peuvent servir de base à la formulation de Médicaments Traditionnels Améliorés (MTA) ou être source de nouvelles molécules antiplasmodiales. Sur la base d'une recherche bibliographique exhaustive, 10 plantes médicinales largement utilisées au Mali dans le traitement du paludisme et des affections hépatiques (ictères) ont été sélectionnées par une approche d'ethnopharmacologie quantitative et évaluées in vitro

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Will, Luiza Sheyla Evenni Porf?rio. "Caracteriza??o f?sico-qu?mica e a??es farmacol?gicas hepatoprotetora, antiinflamat?ria, pr?-angiog?nica, antioxidante e anticoagulante da fra??o rica em fucana 0,8FRF 0,8 da alga marrom Lobophora variegata." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12598.

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Made available in DSpace on 2014-12-17T14:03:40Z (GMT). No. of bitstreams: 1 LuizaSEPW_DISSERT.pdf: 2731256 bytes, checksum: a154afda557a95d39d943b76672810db (MD5) Previous issue date: 2012-12-21<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>This study examines the physical and chemical composition and the pharmacological effects of brown seaweed FRF 0.8 Lobophora variegata. Fractionation of the crude extract was done with the concentration of 0.8 volumes of acetone, obtaining the FRF 0.8. The physicochemical characterization showed that it was a fucana sulfated. Anti-i

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Jung, Chia, and 林佳蓉. "Studies of antioxidant and hepatoprotection of Napiergrass (Pennisetum purpreum S.)." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/14702453470101641790.

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碩士<br>嘉南藥理科技大學<br>生物科技系暨研究所<br>95<br>The aim of the work was to investigate the antioxidant and hepatoprotective effect of water extract of napiergrass (WEN). In the first part, the antioxidant and the effect of WEN, rutin and p-coumaric acid on biomolecules oxidation were explored in vitro. The results showed that WEN, rutin and p-coumaric acid protected liposome, deoxyribose and low-density lipoprotein (LDL) from oxidation, and scavenged free radicals including hydrophilic ABTS+．, hydrophobic DPPH and NO produced from SNP. WEN, rutin and p-coumaric acid showed reducing ability in dose-depend

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Wang, Chia-Hong, and 王嘉宏. "Hepatoprotection of ursolic acid against carbon tetrachloride-induced liver damage in mice." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/07489968472408240903.

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碩士<br>國立成功大學<br>藥理學研究所<br>95<br>Ursolic acid (UA), a pentacyclic triterpenoid exists widely in natural plants, has been shown to have a variety of pharmacological effects: as anti-inflammatory, anti-arthritic, anti-carcinogenic, anti-ulceric, anti-hyperlipidemic and anti-hyper- glycemic activities. Previous researches indicate UA possesses some antioxidant activities, capable of reducing toxic effect of carbon tetrachloride (CCl4). The present investigation aims at studying the hepato-protective activity of UA, with special emphasis placed on knowing the anti-oxidation and anti-fibrosis effect

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Li, Yi-Pin, and 李亦品. "Alcohol- and carbon tetrachloride-induced liver injury as animal models for hepatoprotection evaluation." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/59598966752185133513.

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碩士<br>臺北醫學大學<br>保健營養學系<br>94<br>In this study, we examined the applicability of an animal model for the alcohol-induced liver injury in hepatoprotective evaluation. According to both the plasma AST and ALT activities, 50 male Wistar rats were assigned to five groups: C (control feeding), E (ethanol feeding), ES (ethanol feeding combined with the supplementation of silymarin, 200 mg/kg BW/day), CCL (CCl4 injection and control feeding) and CCLS (CCl4 injection and control feeding combined with the supplementation of silymarin, 200 mg/kg BW/day). Rats were fed for 12 weeks on a control or an etha

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Wen-Yu and 康琝毓. "Hepatoprotection of wild fruiting body of Niuchangchih(Antrodia camphorata) in chronic alcohol consumption." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/35948560576556341288.

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碩士<br>中山醫學大學<br>營養學研究所<br>98<br>A chronic alcohol comsumption can cause alcoholic fatty liver (AFL), further leading to hepatitis, fibrosis, and cirrhosis. Commercially, Antrodia camphorata (AC) is announced a hepatoprotection. Based on our knowledge, a comprehensive report on the wild AC hepatoprotection against a chronic alcohol comsumption is not available. Hence, this study would like to investigate the wild AC hepatoprotection against a chronic alcohol comsumption via regulations of lipid homeostasis, alcohol metabolism, antioxidant capacity, and profibrosis/inflamation in a rat model

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Kumar, K. J. Senthil, and 古山吉. "Anti-inflammation, Hepatoprotection and Anti-melanogeneic Activities of Lucidone from Lindera erythrocarpa Fruits." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/81097218915210589097.

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博士<br>國立中興大學<br>森林學系所<br>99<br>The present study conducted in investigation of various bioactivities of lucidone, a potent immuno-modulatory compound obtained from the fruits of Lindera erythrocarpa. Our previous studies demonstrated that lucidone possessed anti-inflammatory effects; however, the underlying mechanism remained addressed. In this study, we examined the anti-inflammatory activity of lucidone and its mechanism using various in vitro and in vivo model systems. Lucidone significantly inhibited production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lippopolysaccharide (LPS)-i

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Lin, Kun-Hung, and 林昆宏. "Studies on the Antioxidant Activity and Hepatoprotection of Actinidiae caulis Produced in Taiwan." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/73247271684870581578.

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博士<br>中國醫藥大學<br>中國藥學研究所博士班<br>96<br>Actinidiae caulis was described in the Kai-Bau pentsaology. The whole plant of Actinidiae caulis was used as herbal medicine. The stem and root of Actinidia chinensis Planch var. setosa Li were used to treat hepatitis, insomnia, and to be used as cardiotonic-diuretic agent inTaiwan. In the present study, we examined the antioxidant activities of 50% ethanol extracts of five Actinidia species: Actinidia chinensis Planch var. setosa Li (ACS), A. latifolia (Gardn. & Champ.) Merr. (AL), A. rubricaulis Dunn (AR), A. callosa var. ephippioidea C.f.Liang (ACE), and

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高銘遠. "Antioxidative activities and hepatoprotection of the water extracts ofwater caltrop (Trapa taiwanensis Nakai) skins." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/58977952819543889935.

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Chen, Ya-Hui, and 陳雅慧. "In vivo hepatoprotection of water extract of Citrus sinensis on CCl4-induced liver injury." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/11975646292013265056.

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碩士<br>嘉南藥理科技大學<br>保健營養系<br>101<br>The hepatoprotective effect of water extracts of sweet orange (Citrus sinensis) peel (WESP) and its biological compound, hesperidin (HD), on oxidative stress in vivo, are investigated. Oral administration of WESP to rats at 10 and 100 mg/kg bw for 28 consecutive days before a single dose of CCl4 (2 ml/kg bw) demonstrates a significant protective effect by lowering the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and by improving the histological architecture of the rat liver. In addition, WESP attenuates oxidative stress by i

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Chen, Yan-Zhu, and 陳彥竹. "Research of the water extract of corn silk, lotus leaf and dandelion on hepatoprotection." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/27033813421868829945.

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碩士<br>國立屏東科技大學<br>食品科學系所<br>98<br>Liver is the very important organ of human body and its major role is in metabolism and detoxification. However, excessive toxicity and outside stimulation lead to damage of liver, and subsequently cause liver dysfunction. In many kinds of herbs, there are a lot of natural active ingredients including antioxidants which help people to defend the damage caused by free radicals. Corn silk (Maydis stigma), lotus leaf (Nelumbo nucifera Gaertn) and dandelion (Taraxacum officinale) have used for many years because of the efficacies including antioxidation, liver pro

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Huang, Yu-Ju, and 黃鈺如. "Hepatoprotection of Andrographolide and Ethanolic Extract of Andrographis paniculata in Carbon tetrachloride-treated Rats." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/62611338849878374955.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>100<br>Chronic liver diseases and cirrhosis are the eighth leading cause of death in Taiwan. Therefore, prevention and medical therapy of chronic liver diseases is an important public health issue in Taiwan. Andrographis paniculata is a popular Chinese herbal medicine and is reported to display diverse biological activities including hepatoprotection , anti-cancer, and anti-inflammation. The major bioactive compounds of A. paniculata include various flavonoids and terpenoids, and andrographolid (AND), a diterpene lactone, is the most active one. In this study, we i

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Wang, Chih-Cheng, and 王志誠. "Evaluation the Hepatoprotection Effects of Wood Cultivated Antrodia Cinnamomea Fruiting Bodies by New Extraction Method." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/ypex3v.

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碩士<br>中華科技大學<br>健康科技研究所在職專班<br>103<br>The aim of this study was to evaluate the hepatoprotective effect of wood cultivated Antrodia Cinnamomea fruiting bodies extract powder on carbon tetrachloride CCl4-induced liver injuries in rats. Grand Fortune Biotechnology Company provided the Wood Cultivated Antrodia cinnamomea Fruiting Bodies extract powder. In this experiment, male Sprague Dawley (SD) rats were randomly divided into six groups: control, CCl4 group, CCl4+silymarin(200 mg/kg bw), CCl4+(0.44g Antrodia Cinnamomea extract powder/rat), CCl4+(0.88 g/rat), CCl4+(0.176 g/rat). The experimental

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Lekic, Nataša. "Some aspects of molecular mechanisms of xenobiotics' hepatotoxicity and hepatoprotection : Modulatory roles of natural polyphenols." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-327392.

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Background & Aims: Oxidative stress and apoptosis are proposed mechanisms of cellular injury in studies of xenobiotic hepatotoxicity. The aim of this work is to find early signal markers of drug-induced injury of the liver by focusing on select antioxidant/oxidant and apoptotic genes. As well, to address the relationship between conventional liver dysfunction markers and the measured mRNA and protein expressions in the D-galactosamine/lipopolysaccharide and tert-butylhydroperoxide hepatotoxicity models. Furthermore, potential hepatoprotective capabilities of antioxidant polyphenols quercetin a

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Huang, Fu-Long, and 黃福龍. "Valuation on the safety and anti-allergy asthma and hepatoprotection of Osmanthus fragrans flower in Taiwan." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/60769550840610376760.

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碩士<br>中華醫事學院<br>生物科技研究所<br>94<br>The aim of this study was to investigate the safety, anti-allergy asthma, and hepatic protection of Osmanthus fragrans flower in Taiwan on acetaminophen-induced hepatic damage in BALB/c mice. Chapter 2 was evaluates the acute and the 28 days subacute toxicities of O. fragrans flower extract (Kwei-Fah extract; KFE) by 75 % ethanol. In the acute toxicity study, BALB/c mice were single orally administered with 5.0 g/kg (5g KFE) and 10.0 g/kg B.W. (10g KFE) dosages of Kwei-Fah extract to obtain the LD50 value under 72 hr. According to the definition of acute

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"Hepatoprotection of the traditional Chinese medicinal formula Wu-zi-yan-zong-wan against chronic alcohol-induced injury." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074567.

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Finally, the hepatoprotection of the 50%EtWZ was evaluated using rat model. The results indicated that the 50%EtWZ possessed potent hepatoprotective activities. The protective effect of the extract against hepatotoxicity induced by long-term treatment with ethanol might be attributed to its inhibitory action on oxidative stress. Although multiple factors could be involved in the inhibition of oxidative injury in the liver, the inhibition of CYP2E1 pathway and the enhanced GSH-related antioxidant capacity might be responsible for the protective effect. In addition, the 50%EtWZ also produced ant

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FU, ZI-HAN, and 傅梓涵. "In Vivo Hepatoprotection of Chenopodium Formosanum And Its Active Compounds on CCl4 - And Ethanol-Induced Liver Injury." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/30109242306429675919.

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碩士<br>嘉南藥理大學<br>保健營養系<br>104<br>The protective effect of water extracts of Djulis (Chemopodium formosaneum) (WECF) and its bioactive compounds against carbon tetrachloride-induced and alcohol-induced liver injury in rats was investigated. Oral administration of WECF to rats at 2.5 mg/kg bw for 28 consecutive days before a single dose of CCl4 demonstrated a significantly lowered aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, and attenuated histopathological changes in CCl4-treated rats. WECF inhibited lipid peroxidation, restored glutathione (GSH), enhanced superoxi

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Ho, Yi-Chien, and 何宜倩. "TUDY ON THE HEPATOPROTECTION OF ANTRODIA CINNAMOMEA AND ANTI-HEPATOMA ACTIVITIES OF ETHANOLIC EXTRACTS FROM HOPS AND HALOFERAX MEDITERRANEI." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/11737636446604012971.

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博士<br>大同大學<br>生物工程學系(所)<br>96<br>The hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, with more than 1 million new cases estimated annually. Therefore, preventing HCC and HCC therapy is a major research around the world. In the past researches, some herbal extracts used traditionally in hepatic diseases and some bioactive compounds extracted from the secondary metabolites of plant and microorganism have extensive biological activities, such as anti-hepatitis B virus, antioxidation, immunomodulating and anticancer effects. In the first instance, the objective of th

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Lin, Yi-Ling, and 林怡伶. "Cardioprotection and Hepatoprotection of naturally fermented noni (Morinda citrifolia L.) juice in a high fat diet and chronic alcohol consumption." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/25234104799858631065.

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博士<br>中山醫學大學<br>生化暨生物科技研究所<br>101<br>It has been summarized that a western-type dietary habit or chronic alcohol consumption easily results in hyperlipidemic, cardiovascular, and liver disorders. Meanwhile, chronic liver disease and cirrhosis are serious diseases facing to either worldwide or Taiwan. One-year naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. Hence, this dissertation involved three independent studies on the protective effects of NJ against hyperlipidemia, high-fat-diet induced fatty liver, and alcoholic fatty livers, respect

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