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Journal articles on the topic 'Hepatoprotector'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Hidayah, Himyatul. "POTENSI TUMBUHAN JAMBLANG (Syzygium cumini (L.) Skeels) SEBAGAI HEPATOPROTEKTOR BERDASARKAN KANDUNGAN SENYAWA AKTIF : LITERATURE REVIEW ARTICLE." Jurnal Buana Farma 3, no. 1 (2023): 1–6. http://dx.doi.org/10.36805/jbf.v3i1.774.

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Damage to the liver can cause disruption of metabolism in the body, so a hepatoprotector is needed as a protector from liver damage which can be obtained from jamblang plants. The aim of this research is to know the content of active compounds contained in jamblang plants which work as hepatoprotectors. By reviewing some of the literature related to this, the results obtained were 10 articles used. In this study using Literature Review Article through electronic data sources, namely: Google Scholar, ScienceDirect and Pubmed which were published 10 years ago with the keywords: Syzygium cumini (

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Matvienko, Yu O., O. R. Panasyukova, O. M. Rekalova, V. M. Zhadan, and C. G. Yasir. "The Use of Natural Hepatoprotector with Immunomodulating Properties in Patients with Pulmonary Tuberculosis with Various Adverse Reactions to Antituberculosis Drugs." Asthma and allergy 2023, no. 4 (2023): 31–37. http://dx.doi.org/10.31655/2307-3373-2023-4-31-37.

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Abstract. The study of the characteristics of the immunological manifestations of toxic-allergic reactions (TAR) of drug intolerance to antituberculosis drugs (ATD) in patients with pulmonary tuberculosis (TB), determining the most rational ways of immunocorrection with clinical manifestations of the TAR are relevant and will help to increase the effectiveness of the treatment of such patients by reducing their amount complications in treatment. The aim of the work: to study the effectiveness of the use of natural hepatoprotector from biomass lysate of probiotic lactic acid bacteria in the com

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Muhammad Hasan Andryanto, Fauna Herawati, and Umi Fatmawati. "LAPORAN KASUS: ANALISIS KOMBINASI PENGGUNAAN HEPATOPROTEKTOR PADA CEDERA HATI KARENA INFEKSI BAKTERI STREPTOCOCCUS VIRIDANS." JIIS (Jurnal Ilmiah Ibnu Sina): ilmu farmasi dan kesehatan. 9, no. 2 (2024): 431–44. https://doi.org/10.36387/jiis.v9i2.2179.

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Streptococcus viridans is one of the bacteria that can cause Community-Acquired Pneumonia (CAP). CAP disease has a higher prevalence of non-alcohol-related fatty liver disease (NAFLD). Continuous increase in fat levels in the liver triggered by pneumonia can cause inflammation in the liver, it causes a rapid decline in liver function and results in increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin. The use of hepatoprotectors in conditions of impaired liver function is essential to improve liver cell regeneration and promote liver detoxif

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Osyodlo, H. V., M. P. Boichak, and O. O. Fedorova. "Rational choice of hepatoprotectors for drug-induced liver injury." GASTROENTEROLOGY 56, no. 3 (2022): 179–89. http://dx.doi.org/10.22141/2308-2097.56.3.2022.507.

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The article deals with a review of the current literature on the clinical use of hepatoprotectors in drug-induced liver injury. The literature was searched in Scopus, Web of Science, PubMed and other databases. Risk factors, pathogenetic mechanisms of liver damage, international diagnostic criteria and treatment for drug-induced liver injuries are considered. Clinical and pharmacological approaches to the choice of hepatoprotectors for the management of drug-induced liver injury are substantiated. The positive effects of ademetionine, a hepatoprotector, are highlighted — choleretic, cholekine

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Damayanti, Kusmadewi Eka, Noor Wijayahadi, and Niken Puruhita. "Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum." Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 4, no. 1 (2016): 63–66. http://dx.doi.org/10.14710/jgi.4.1.63-66.

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Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks ag

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Gromova, O. A., I. Yu Torshin, V. I. Demidov та ін. "Experimental medicinal hepatitis. Hepatoprotective eﬀects of the drug Laennec in models of toxic liver injury with paracetamol or alcohol". Experimental and Clinical Gastroenterology, № 3 (5 жовтня 2022): 86–92. http://dx.doi.org/10.31146/1682-8658-ecg-199-3-86-92.

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Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents the results of a study of the Laennec hepatoprotector, produced on the basis of pharmaceutically standardized human placental hydrolysates (HPH). The use of HSP in toxic liver damage with alcohol or paracetamol led to a signiﬁcant decrease in markers of liver dysfunction (AST, ALT, bilirubin, MDA), which increase when the models are reproduced. The hepatoprotective eﬀect of Laennec was conﬁ rmed by the results of histological studies, indicating a reduction in

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Salsabila, Khalisah Nurjihany, and Ester Krisdayanti. "The Potensi Ekstrak Daun Kelor sebagai Hepatoprotektor terhadap Hepatotoksisitas Akibat Induksi Parasetamol." Jurnal Farmasetis 8, no. 2 (2019): 95–100. http://dx.doi.org/10.32583/farmasetis.v8i2.631.

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Parasetamol merupakan anti-piretik yang paling umum digunakan dan bisa didapat secara bebas. Parasetamol tidak beracun jika diberikan dalam dosis terapi, namun jika diberikan dalam dosis tinggi secara tunggal maupun berulang parasetamol dapat menyebabkan efektoksik. Toksisitas parasetamol merupakan salah satu penyebab keracunan paling umum didunia dan dapat menyebabkan kerusakan hepar bahkan kematian. Tanaman kelor atau Moringaoleifera merupakan tanaman yang mengandung berbagai senyawa kimia bermanfaat dan dapat digunakan sebagai pengobatan alternatif. Studi sebelumnya melaporkan tanaman kelor

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Gerush, Oleg, Olena Lenytska, Larysa Yakovleva, Liudmyla Gladkova, and Igor Gerush. "Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats." Current Issues in Pharmacy and Medical Sciences 27, no. 4 (2014): 240–42. http://dx.doi.org/10.1515/cipms-2015-0024.

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Abstract This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector

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Ardiyanto, D., Z. Zulkarnain, P. R. W. Astana, et al. "Efficacy of hepatoprotector jamu formula (combination of Curcuma longa, Curcuma xanthorrhiza, and Taraxacum officinale) compared to Fructus schizandrae extract in mild liver injury: a randomized controlled trial." IOP Conference Series: Earth and Environmental Science 913, no. 1 (2021): 012089. http://dx.doi.org/10.1088/1755-1315/913/1/012089.

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Abstract The prevalence of impaired liver function in developing countries is increasing. Indonesia has several traditional medicines that can be used as alternative treatments for liver dysfunction. The aim of this study was to determine the efficacy of hepatoprotector jamu formula (combination of Curcuma longa, Curcuma xanthorrhiza, and Taraxacum officinale) compared to Fructus schizandrae fruit extract for treating mild liver injury. This study was a RCT using parallel open label design which involved 60 subjects for 42 days of intervention. The parameters used to evaluate efficacy were Ser

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Jiménez-Arellanes, María Adelina. "Silimarina como potencial agente hepatoprotector." Revista Cadena de Cerebros 3, no. 2 (2019): 60–70. https://doi.org/10.5281/zenodo.3903937.

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<strong>RESUMEN</strong> El hígado es el encargado de la homeostasis y de metabolizar diversas sustancias (endógenas y exógenas, incluyendo fármacos), las cuales al metabolizarse generan metabolitos más tóxicos y/o reactivos; por esto el hígado es más susceptible de sufrir algún daño como cirrosis, esteatosis y/o hasta hepatocarcinoma. El ser humano ha empleado diversas plantas medicinales (PM) desde tiempos ancestrales para tratar sus padecimientos, enfermedades y dolencias; entre ellas esta Sylibum marianum. Planta utiliza

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11

Skvortsov, V. V., E. M. Skvortsova, V. V. Kolomytsev, and L. V. Goryunova. "Acute alcoholic hepatitis – the role of modern hepatoprotectors." Meditsinskiy sovet = Medical Council, no. 8 (June 9, 2024): 98–107. http://dx.doi.org/10.21518/ms2024-215.

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Alcoholic hepatitis is a progressive inflammatory-dystrophic lesion of the liver, the pathogenetic mechanism of which is based on alcoholic damage. Acute alcoholic hepatitis is defined primarily as an exacerbation of the chronic process of alcoholic liver disease. Two mechanisms are defined as the basis for the formation of alcohol-associated liver damage: primary (direct effect of ethanol on hepatocytes and oxidative stress provoked by it) and secondary (through changes in the gut-liver axis with dysbacteriosis and increased permeability of the intestinal wall). For the treatment of acute alc

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Brus, Tatiana V., Maria A. Pahomova, and Andrey G. Vasiliev. "Correction of hepatic dysfunction in an extensive deep burn model." Pediatrician (St. Petersburg) 8, no. 2 (2017): 62–67. http://dx.doi.org/10.17816/ped8262-67.

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The ongoing increase of burn trauma rates urges elaboration of valid and effective methods of medical aid with actualization of pathogenetically-based intensive therapy. Burn disease is a peculiar nosologic form characteristic of local manifestations as well as critical systemic state with involvement of internal organs and systems with subsequent development of polyorganic insufficiency. Liver lesions in case of burn disease are multiform and often combine with disturbances of other organs yielding polyorganic insufficiency. Desintoxicating, hepatoprotector and organoprotector effects of succ

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Troncoso, Luzmila, and Emilio Guija. "Efecto antioxidante y hepatoprotector del Petroselinum sativum (perejil) en ratas, con intoxicación hepática inducida por paracetamol." Anales de la Facultad de Medicina 68, no. 4 (2013): 333. http://dx.doi.org/10.15381/anales.v68i4.1199.

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Objetivo: Determinar el efecto antioxidante y hepatoprotector del perejil (Petroselinum sativum) en ratas con intoxicación hepática inducida por paracetamol. Lugar: Centro de Investigación de Bioquímica y Nutrición – “Laboratorio de Bioquímica Clínica y Nutricional “Leonidas Delgado Butrón” “Emilio Guija Poma” – Universidad Nacional Mayor de San Marcos. Lima, Perú. Diseño: Estudio analítico, transversal, prospectivo y cuasi-experimental. Material: Ratas albinas Holtzman machos adultas. Métodos: Se utilizó 40 ratas de 2 meses de edad, con pesos entre 280 y 320 g, distribuidas aleatoriamente en

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14

Suparni, ,., ,. Musthari, Liza Mutia, et al. "The Hepatoprotector Effect of Uncaria gambir Roxb Extract in Wistar Rats Induced by Paracetamol." Journal of Drug Delivery and Therapeutics 10, no. 6-s (2020): 61–66. http://dx.doi.org/10.22270/jddt.v10i6-s.4457.

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Background: Drug induced liver injury (DILI) is known as the damage of liver cells due to chronic administrations of drug. The chronic administration of paracetamol could be trigger the damage of liver cells.The hepatoprotector agents are still limited worldwide. Gambier(Uncaria gambir Roxb) is an Indonesia’traditional medicine which have many benefits as antioxidant, antiseptic, antidiarrhoea, etc that commonly used in society.  Method: The present study was conducted to investigate the hepatoprotector effect ofgambier in wistar rats induced by paracetamol. The wistar rats were divided

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Sari, Yusriana, and Teti Rahmawati. "Pengetahuan berhubungan dengan Kepatuhan Pasien Hepatitis B dalam Menjalani Terapi Hepatoprotektor." Jurnal Akademika Baiturrahim Jambi 11, no. 1 (2022): 32. http://dx.doi.org/10.36565/jab.v11i1.431.

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Hepatitis B patients who do not comply with consuming natural medicinal compounds containing hepatoprotective will experience a decrease in health, low antiviral activity, antioxidants for the body and lead to complications of other diseases. The purpose of this study was to determine the relationship between knowledge and patient compliance in undergoing hepatoprotector therapy at the internal medicine polyclinic of Gatot Soebroto Hospital. This study used a cross sectional design. The number of samples in this study were patients with chronic hepatitis B at the Internal Medicine Polyclinic o

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Mekhtiev, S. N., O. A. Mekhtieva та O. M. Berko. "Rational Сhoice of Нepatoprotectors in the Treatment of Chronic Liver Diseases". Effective Pharmacotherapy 19, № 35 (2023): 50–58. http://dx.doi.org/10.33978/2307-3586-2023-19-35-50-58.

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The modern pharmacological industry provides healthcare professionals and patients with the widest choice of medicines (drugs) and biologically active additives. At the same time, the choice of the drug, in addition to the instructions for use and clinical recommendations, is influenced by personal experience of use (both the doctor and the patient), the cost of the drug, advertising and other factors. The Register of Medicines of Russia contains about 30 hepatoprotectors and their combinations, represented by more than 130 original drugs and their generics. This article presents data on the e

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Alfaro-Ayvar, Janet Rocio, Luis Alberto Inostroza-Ruiz, and Américo Jorge Castro-Luna. "Efecto protector de Hylocereus monocanthus en la hepatotoxicidad aguda inducida por tetracloruro de carbono en ratas." Ciencia e Investigación 25, no. 1 (2022): 3–9. http://dx.doi.org/10.15381/ci.v25i1.19744.

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Los frutos de Hylocereus monacanthus se consideran una fuente prometedora de antioxidantes naturales por lo que es un alimento considerado funcional y nutraceútico. El objetivo de este estudio fue determinar la actividad hepatoprotectora del extracto etanólico del Hylocereus monacanthus (EEtH) en ratas albinas con toxicidad aguda inducida por tetracloruro de carbono. Mediante un análisis fitoquímico se demostró que el fruto de Hylocereus monacanthus contiene fenoles, flavonoides, entre otros metabolitos secundarios; la actividad hepatoprotectora se evaluó a través del ensayo bioquímico de la a

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Rahmawati, Laily, Erma Sulistyaningsih, and Rosita Dewi. "Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin." Pustaka Kesehatan 6, no. 2 (2018): 251. http://dx.doi.org/10.19184/pk.v6i2.7617.

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 The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples

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Huberhrits, N. B., O. Ye Klochkov, P. H. Fomenko, and N. V. Bieliaieva. "Multipotent Hepatoprotector Larnamin in Clinical Practice." GASTROENTEROLOGY, no. 1.59 (April 26, 2016): 39. http://dx.doi.org/10.22141/2308-2097.1.59.2016.74513.

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Firman, Gelline Tama Anindia, Min Rahminiwati, and Ike Yulia Wiendarlina. "AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK AIR PEGAGAN (Centella asiatica L. Urban) DAN EKSTRAK ETANOL KUNYIT (Curcuma longa Linn) TERHADAP TIKUS PUTIH JANTAN SPRAGUE DAWLEY." FITOFARMAKA: Jurnal Ilmiah Farmasi 7, no. 1 (2017): 13–28. http://dx.doi.org/10.33751/jf.v7i1.797.

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ABSTRAKHepatoproktektor adalah senyawa yang dapat mencegah dan memperbaiki sel-sel hepar yang rusak. Parameter yang diamati adalah perubahan kadar SGPT pada hari ke 0,2, 5, 9 dan 13. Hasil penelitian dari 9 kombinasi dosis selama 13 hari menunjukkan semua kombinasi menurunkan kadar SGPT dengan aktivitas hepatoprotektor terbaik adalah terdapat pada tumbuhan ektrak air pegagan: ekstrak etanol kunyit dengan perbandingan 2:3.Kata kunci: Pegagan (Centella asiatica L.Urban), Kunyit (Curcuma longa Linn) dan hepatoprotektorABSTRACTHepatoprotector is a compound that can prevent and repair liver cell da

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Saucedo Estela, Pamela Yanina. "Efecto hepatoprotector del extracto hidroalcohólico de Desmodium molliculum (“manayupa”) en ratas con intoxicación hepática inducida por paracetamol." Revista Científica Ágora 6, no. 2 (2019): e4. http://dx.doi.org/10.21679/arc.v6i2.131.

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Objetivo: Determinar el efecto hepatoprotector del extracto hidroalcohólico de Desmodium molliculum (“manayupa”) a diferentes concentraciones (50, 500 y 800 mg/kg), además de evaluar sus metabolitos activos. Materiales y Métodos: Se empleó extracto hidroalcohólico de D. molliculum en ratas Holtzman distribuidas de forma aleatoria en seis grupos (n=5), las cuales recibieron los siguientes tratamientos, por diez días, vía peroral: grupos I y II: suero fisiológico 10 mL/kg; grupo III: silimarina 100 mg/kg; grupo IV: 50 mg/kg; grupo V: 500 mg/kg y grupo VI: 800 mg/kg del extracto hidroalcohólico d

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Wu, Tai-Wing, Ling-Hua Zeng, Jun Wu, and Doug Carey. "Purpurogallin—a natural and effective hepatoprotector in vitro and in vivo." Biochemistry and Cell Biology 69, no. 10-11 (1991): 747–50. http://dx.doi.org/10.1139/o91-113.

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Purpurogallin is a plant phenol that is sometimes added as an oxidation retardant to fats–oils or to certain fuels or lubricants. However, it was unknown if purpurogallin is cytoprotective. Here we examined this issue, both in isolated hepatocytes and in vivo. From 0.5 to 2.0 mM, purpurogallin prolongs survival of rat hepatocytes substantially against oxyradicals generated with xanthine oxidase and hypoxanthine. The protection was dose dependent and surpassed that given by such antioxidants as ascorbate, mannitol, superoxide dismutase, catalase, and Trolox, when each was examined at or near it

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Renovaldi, Dede, and Abdul Khalik Adam. "Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs." Muhammadiyah Medical Journal 1, no. 2 (2020): 63. http://dx.doi.org/10.24853/mmj.1.2.63-68.

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The use of drugs is one of the most common causes of liver injury, because the liver is the main organ that metabolizes drugs. Little is currently done if there is a liver injury due to the hepatotoxic side effects of a drug. Herbal plants have active natural compounds that have pharmacological effects so they are widely used as alternative treatments. Sweet basil (Ocimum basilicum) is one of the most cultivated plants in Asia. Studies on the use of Ocimum basilicum in medicine have been carried out, one of which is the hepatoprotector effect. Studies indicate that Ocimum basilicum is rich in

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Renovaldi, Dede, and Abdul Khalik Adam. "Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs." Muhammadiyah Medical Journal 1, no. 2 (2020): 21. http://dx.doi.org/10.24853/mmj.1.2.21-26.

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The use of drugs is one of the most common causes of liver injury, because the liver is the main organ that metabolizes drugs. Little is currently done if there is a liver injury due to the hepatotoxic side effects of a drug. Herbal plants have active natural compounds that have pharmacological effects so they are widely used as alternative treatments. Sweet basil (Ocimum basilicum) is one of the most cultivated plants in Asia. Studies on the use of Ocimum basilicum in medicine have been carried out, one of which is the hepatoprotector effect. Studies indicate that Ocimum basilicum is rich in

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Herlianto, Budi, Syifa Mustika, Supriono -, Bogi Pratomo, and Harijono Achmad. "Role of Phytopharmacy as Hepatoprotector in Chronic Hepatitis." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 15, no. 3 (2014): 157–60. http://dx.doi.org/10.24871/1532014157-160.

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Background: Hepatitis is one of the health problems in Indonesia that require special treatment, in line with the increase of morbidity and mortality rate of this disease. Complications of hepatitis include liver cirrhosis and hepatocellular carcinoma. Indonesia, as a tropical country, has many medicinal plants that act as hepatoprotector, a substance that can protect liver from toxic agent. Use of medicinal plants is still considered as controversial treatment because there is still lack of studies. Medicinal plants with mix composition of phytopharmacy, such as: Curcuma xanthorrhiza, Arcange

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Xavier, JaniferR, Ramaswamy Gnanam, MuthiahP Murugan, and Anju Pappachan. "Clonal propagation of Phyllanthus amarus: A hepatoprotector." Pharmacognosy Magazine 8, no. 29 (2012): 78. http://dx.doi.org/10.4103/0973-1296.93332.

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Peralta Adauto, Laura Perla, Juan Antonio Barrera Jiménez, Gabriela Medina Pérez, Rafael German Campos Montiel, Ruben Jiménez Alvarado, and Uriel González Lemus. "Efecto antinflamatorio y hepatoprotector de extractos vegetales." Boletín de Ciencias Agropecuarias del ICAP 7, no. 14 (2021): 10–13. http://dx.doi.org/10.29057/icap.v7i14.7589.

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Actualmente en México el padecimiento de enfermedades inflamatorias de caracter gástrico y hepáticas ha venido aumentando con mayor frecuencia de acuerdo al Instituto Nacional de Estadística y Geografía (INEGI, 2021) siendo la gastritis y la Enfermedad del Hígado No Graso (EHGNA) las más recurrentes. Éstas se relacionan principalmente con el estilo de vida, factores simples como el abuso irresponsable de medicamentos antiinflamatorios no esteroideos (AINE), el consumo excesivo de grasas, agentes alcalinos, ácidos fuertes y la presencia de la bacteria Helicobacter pylori (Hernández−Cortez et al

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Zama, Ayesha, and Ravi R. Chavan. "CRITIQUE ON JALODARARI RASA - A MIGHTY HEPATOPROTECTOR." International Ayurvedic Medical Journal 9, no. 11 (2021): 2756–63. http://dx.doi.org/10.46607/iamj1809112021.

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Ayurveda is the oldest methodical branch of knowledge that speaks its reality in the sketch of philosophy. It comprises most scientific milieu of derivation. As per ancient Ayurveda scholars for getting a desirable outcome of any medication, it should be precisely analysed before prescribing to the patient. There are several classical formulations successfully practised by Ayurveda physicians for treating various ailments, and also there are few unexplored but potent formulations that need the attention of practitioners to come to light. The present study is based to collaborate various refere

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Kresnapati, I. Nyoman Bagus Aji, Salsabila Yunita Kurniawan, Novitarini Novitarini, and Baiq Yulia Hasni Pratiwi. "Hepatoprotector Edible Flower in Indonesia: A Review." Jurnal Pijar Mipa 20, no. 3 (2025): 544–53. https://doi.org/10.29303/jpm.v20i3.8983.

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Hepatotoxicity is an agent that causes damage to human liver function, and every year, cases of liver damage are increasing. Agents that cause liver damage, such as drugs (Paracetamol), chemicals, Carbon Tetrachloride (CCL4), cause liver damage, which is characterized by an increase in the liver enzymes Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Giving natural ingredients such as edible flower extracts (hepatoprotectors) can reduce SGOT and SGPT levels in liver damage (Hepatoxicity). Indonesia is a country rich in biodiversity, including edib

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Yaremchuk, V. Y., and L. G. Slivinska. "Prevention of hepatosis in laying hens using hepatoprotectors Hep-A-Stress and Hepasan-VS." Ukrainian Journal of Veterinary and Agricultural Sciences 3, no. 3 (2020): 8–14. http://dx.doi.org/10.32718/ujvas3-3.02.

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The article presents the results of preventive efficacy of hepatoprotectors Hep-A-Stress and Hepasan-VS in laying hens with hepatosis. The research was conducted in modern poultry farm. Three groups of laying hens (control and two experimental) Lohmann Brown breed (n = 1500) aged 224 days were formed. The poultry was kept on the main ration according to the technological map for the use of this breed. Laying hens from the first experimental group were additionally given hepatoprotector Hep-A-Stress and the second – Hepasan-VS. Blood sampling for the study was performed three times: before the

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Romanova, A. I., and E. L. Krasavtsev. "THE MODERN ASPECTS OF HEPATOPROTECTOR THERAPY IN LEAVER DISEASES." Health and Ecology Issues, no. 2 (June 28, 2007): 42–50. http://dx.doi.org/10.51523/2708-6011.2007-4-2-7.

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The analytical review of references on the effectiveness of hepatoprotectors of different groups was made. The various classifications and clinical pharmacology of hepatoprotectors were reviewed. The analysis of preparations effectiveness of new groups was done.

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Nessa, Nessa, Ifmaily Ifmaily, Yeliza Putri, and Ridho Asra. "Hepatoprotector Effect of Corn Silk Ethanol Extract (Stigma maydis) on Paracetamol-Induced White Male Rats." Asian Journal of Pharmaceutical Research and Development 9, no. 5 (2021): 10–16. http://dx.doi.org/10.22270/ajprd.v9i5.1008.

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Objectives: Corn silk (Stigma maydis) is one part of the corn plant that contains useful chemical compounds, including flavonoid compounds. The ability of flavonoid compounds to capture free radicals that cause liver damage. The purpose of this study was to determine the hepatoprotective effect of corn silk ethanol extract on male white rats induced by paracetamol and to determine the effect of varying doses of corn silk ethanol extract as a hepatoprotector. Data Sources Study Selection: This study is an experimental study testing the hepatoprotective effect of corn silk ethanol extract

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Zabokritsky, N. "Development of experimental sample of a new hepatoprotector." Российский иммунологический журнал 12(21), no. 3 (2018): 301–5. http://dx.doi.org/10.31857/s102872210002399-3.

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Zykova, Svetlana, Sergey Shurov, Aleksey Savinkov, Nino Gugushvili, and Vladimir Talismanov. "Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector." BIO Web of Conferences 17 (2020): 00061. http://dx.doi.org/10.1051/bioconf/20201700061.

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The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compa

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Matysik, S. I., B. P. Kuzminov, and D. D. Ostapiv. "CYTOTOXIC ACTION OF HEPATOPROTECTOR ANTRAL ON BULL SPERM." Hygiene and sanitation 99, no. 2 (2020): 206–9. http://dx.doi.org/10.33029/0016-9900-2020-99-2-206-209.

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Introduction. According to the European legislation and requirements, industrial production of medication shall be provided with well-defined regulations of the quality of such preparation. Material and methods. Cytotoxic action of hepatoprotector Antral on bull sperm was evaluated. Samples of sperm were divided into control and two experimental samples: control one was diluted with phosphate-buffered saline (PSB), which included NaCl - 0.8 g, KСl - 0.02 g, Na2HPO4 - 0.11 g, КH2PO4 - 0.02 g, MgCl2 - 0.01 г, Н2О till 100ml; in the first experimental sample PSB was added with antral in the dose

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Edward, Zulkarnain. "PEMANFAATAN FUNGSI ANTI OKSIDAN GAMBIR (Uncaria gambir) SEBAGAI HEPATOPROTEKTOR." Jurnal Riset Kimia 2, no. 2 (2015): 201. http://dx.doi.org/10.25077/jrk.v2i2.163.

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ABSTRACT The aim of the research is to find out the effect of the hepatoprotector from gambier to some rats animal contaminated by carbon tetrachloride (CCl4). The research was done in Biochemistry laboratory Medical Faculty Andalas University Padang applied to 12 galur wistar rats species in about ± 2 months ages with 170-200 g weight, which are separated into 3 groups (clusters). They are cluster in negative control, in positive control (CCl4 2 mg/kgBB inductions), and treated cluster (CCl4 inductions and 10 mg/kgBB gambier given). Statistically analyzed the data by one way Anova test with 9

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Amanda Putri, Khairunnisa Rizqika, Evi Lusiana, Theodorus, Ayeshah Augusta Rosdah, Debby Handayati Harahap, and Veny Larasati. "EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW." Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya 12, no. 1 (2025): 21–29. https://doi.org/10.32539/jkk.v12i1.453.

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Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results ob

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Голодяева, Мария Сергеевна, Алексей Викторович Прусаков, Анатолий Викторович Яшин, and Владимир Дулмажапович Раднатаров. "THE EFFECT OF THE HEPATOPROTECTOR "GEPALAN" ON CLINICAL AND MORPHOLOGICAL PARAMETERS OF BLOOD IN FIRST-CALF COWS WITH HEPATOSIS." Вестник Бурятской государственной сельскохозяйственной академии имени В. Р. Филиппова, no. 2(63) (June 25, 2021): 136–40. http://dx.doi.org/10.34655/bgsha.2021.63.2.019.

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Экспериментальные исследования проводились на животноводческом комплексе промышленного типа молочного направления. Объектом для исследования служили - глубокостельные нетели черно-пестрой породы живой массой 450,0-470,0 кг. На основании принципа аналогов были отобраны контрольная (n=15) и опытная (n=15) группы. Животным опытной группы к основному рациону за месяц до предполагаемого отела добавляли гепатопротектор «Гепалан» один раз в день в дозе 25,0 мл на голову согласно инструкции по использованию препарата. Дачу препарата прекращали после отела. Опытным путем установлено, что использование

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Enciso Roca, Edwin C., Enrique J. Aguilar Felices, Pablo W. Común Ventura, and Jorge L. Arroyo Acevedo. "Efecto hepatoprotector y actividad antioxidante del extracto hidroalcohólico del fruto de dos variedades de Opuntia megacantha “tuna”." Investigación 28, no. 2 (2020): 252–59. http://dx.doi.org/10.51440/unsch.revistainvestigacion.28.2.2020.416.

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El presente trabajo de investigación se realizó con el objetivo de determinar el efecto hepatoprotector y actividad antioxidante del extracto hidroalcohólico del fruto de dos variedades de Opuntia megacantha “tuna”, morada y anaranjada. El contenido de fenoles totales se determinó por el método de Folin-Ciocalteu y los flavonoides por el método del cloruro de aluminio. La actividad antioxidante por los métodos de DPPH, ABTS y FRAP; y el efecto hepatoprotector mediante ensayo in vivo en ratas albinas de 2 meses de edad, con pesos entre 200 ± 20 g, distribuidas aleatoriamente en siete grupos de

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Saavedra, Félix, Gloria Gordillo, Haydée Zúñiga, José Apesteguía, and Henry Ostos. "EFECTO HEPATOPROTECTOR DEL GEL DE Aloe vera L. MODIFICADO FRENTE A LA INJURIA INDUCIDA EN RATONES CON ACEITE COMESTIBLE RECALENTADO MEZCLADO CON DMSO." Ciencia e Investigación 18, no. 1 (2015): 14–19. http://dx.doi.org/10.15381/ci.v18i1.13600.

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El objetivo del presente estudio fue evaluar el efecto hepatoprotector del gel de Aloe vera modificado (GAVM) frente a la injuria inducida en ratones albinos por la administración, vía oral, de aceite comestible recalentado (ACR) mezclado con dimetilsulfóxido (DMSO) (1:1). Las dosis de ACR usadas fueron 2,3 y 3,1 mL/kg, administradas por 14 días, lo cual produjo incremento de las transaminasas (ALT, AST) y triglicéridos. A los ejemplares que recibieron la menor dosis de ACR (2,3 mL/kg de peso), a partir del día 14 y por 18 días, se les suministró, adicionalmente, cuatro gotas diarias de GAVM e

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Enciso, Edwin C., Enrique J. Aguilar, Pablo W. Común, and Yovani M. Condorhuamán. "Efecto hepatoprotector y actividad antioxidante del extracto hidroalcohólico del fruto de dos variedades de Opuntia megacantha “Tuna”." Ciencia e Investigación 23, no. 1 (2020): 51–58. http://dx.doi.org/10.15381/ci.v23i1.18752.

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El presente trabajo de investigación se realizó con el objetivo de determinar el efecto hepatoprotector y actividad antioxidante del extracto hidroalcohólico del fruto de dos variedades de Opuntia megacantha “tuna”, morada y anaranjada. El contenido de fenoles totales se determinó por el método de Folin-Ciocalteu y los flavonoides por el método del cloruro de aluminio. La actividad antioxidante por los métodos de DPPH, ABTS y FRAP; y el efecto hepatoprotector mediante ensayo in vivo en ratas albinas de 2 meses de edad, con pesos entre 200 ± 20 g, distribuidas aleatoriamente en siete grupos de

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Khamidova, T. V., E. V. Kozhevnikova, V. G. Kiryukhin, and B. N. Filatov. "On the problem of secondary prevention of hepatotropic manifestations of dioxyne intoxication." Kazan medical journal 78, no. 1 (1997): 55–57. http://dx.doi.org/10.17816/kazmj81123.

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The liver morphology in intoxication by 2-(a-fluor-a-trifhiormethoxymethyl) benzimidazol, 2-a- hydrotetrafluorethy) benzimidazol and 5 (6)-(2-oxy-hexafluorisopropil)-2-(a-fluor-a-trifluormethoxymethyl) benzimidazol is studied experimentally on rats. Vaseline oil in large doses manifests hepatoprotector property early in intoxication.

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Gan, Emilia, Yenry Sumarlim, Desantika Wuryana, et al. "Hepatoprotector in cases of dengue hemorrhagic fever as a prevention of hepatic damage: a case report." Jurnal Teknologi Laboratorium 12, no. 1 (2023): 46–52. https://doi.org/10.29238/teknolabjournal.v12i1.424.

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Dengue Hemorrhagic Fever (DHF) is classified as an arbovirus disease which is a public health problem in the world. The causative agent of DHF is the dengue virus, namely the RNA virus of the genus Flavivirus and the family Flaviviridae. Hepatic impairment is often observed in DHF cases with asymptomatic or asymptomatic elevations in serum transaminases up to severe manifestations in the form of acute liver failure. It was reported that DHF patients had mild hepatic impairment with clinical manifestations of mild hepatomegaly, hypoalbumin, normal SGOT/SGPT values, and clinical conditions of na

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Arnao-Salas, Acela Inés, Silvia Suárez-Cunza, Juan Trabucco-Ricaldi, Ruth Cisneros-Chinchay,, and María Elena Rodrigo. "Efecto hepatoprotector del extracto acuoso de Smallanthus sonchifolius (yacón) en un modelo de intoxicación con acetaminofén." Anales de la Facultad de Medicina 73, no. 3 (2012): 239. http://dx.doi.org/10.15381/anales.v73i3.871.

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hepatoprotector. Objetivos: Evaluar en suero y hematíes el efecto hepatoprotector del extracto acuoso de hojas de yacón (EAY) en un modelo de intoxicación con acetaminofén en ratas. Diseño: Experimental, transversal. Institución: Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Hojas de yacón. Intervenciones: Se formó cinco grupos de ratas hembra (n=6) que recibieron por cinco días, por vía oral, suero fisiológico (SF), EAY o silimarina (Sil) (50 mg/kg) y luego de 1 hora, SF o acetaminofén (A) 250

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Masykur, Masykur, Nurdin, Lukman Hakim, et al. "Effect of Ethanol Extract of Sugar Apple (Annona squamosa L.) Stem Bark on Rat SGPT and SGOT." Jurnal Penelitian Pendidikan IPA 9, no. 10 (2023): 8695–706. http://dx.doi.org/10.29303/jppipa.v9i10.4773.

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This study aims to compare hepatoprotector potency of the ethanol extract of sugar apple (A. squamosa) stem bark (EESSB) against the enzyme activity of SGOT and SGPT in rats induced by toxic doses of paracetamol. The method used in this study is Completely Randomized (CRD) consisting of 6 treatment groups and 3 replications. The parameters that are being observed in this study are phytochemical, antioxidant, clinical symptoms, macroscopic, SGOT and SGPT rats. Data were analyzed using Analysis of Variance (ANOVA) with a significant level of 5% with the Duncan test as a follow-up test. The clini

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Khaleeva, N. B., A. L. Arbuzov, and A. A. Romanov. "EXPERIENCE OF USING THE INNOVATIVE MEDICINAL HEPATOPROTECTOR GEPAFOR® WITH A PROBIOTIC COMPONENT IN THE TREATMENT OF ALCOHOLIC LIVER DISEASE." Bulletin of the Medical Institute of Continuing Education 5, no. 2 (2025): 122–26. https://doi.org/10.36107/2782-1714_2025-5-2-122-126.

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Background. The positive effect of the combined use of hepatoprotectors and probiotics in acute viral hepatitis was noted in the work of L.G. Pyatov and V.A. Martynov. However, until recently, there was no drug on the pharmaceutical market that contained hepatoprotector and probiotic in a single dosage form. Hepatoprotectors are traditionally used to restore liver cells, more than half of which are herbal preparations. The interest in them is caused by the variety of mechanisms of protective action, a wide range of applications, easy and rather complete assimilation in the body, high safety an

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Sukhanova, A. A., and M. Yu Egorov. "The role of hepatoprotective and venotonic treatment in the prevention of recurrence of benign and borderline ovarian tumors after performing conservative organ-sparing operations." HEALTH OF WOMAN, no. 7(133) (September 30, 2018): 89–95. http://dx.doi.org/10.15574/hw.2018.133.89.

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The objective: to increase the efficiency of treatment of patients with benign (DEOA) and borderline (PEOI) epithelial ovarian tumors after performing organ-sparing operations based on the appointment of a comprehensive anti-relapse therapy. Materials and methods. A clinical examination of 246 patients was conducted. The retrospective group consisted of 112 patients with DEOI and PES. The retrospective group was divided into two subgroups: І subgroup - 85 (75.9%) patients with DEEA; The second subgroup – 27 (24.1%) patients with PED. The prospective group included 60 patients with EOJ, of whom

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Kharchenko, V. V., and H. A. Anokhina. "Selection of hepatoprotector in multimorbid diseases of hepatobiliary system." Modern Gastroenterology, no. 4 (September 28, 2018): 36–42. http://dx.doi.org/10.30978/mg-2018-3-36.

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Lukivskaya, O., Y. U. Marakhovsky, E. Belonovskaya, E. Naruta, and V. U. Buko. "944 GLYCYL-GLYCINE AS HEPATOPROTECTOR IN EXPERIMENTAL ALCOHOLIC STEATOHEPATITIS." Journal of Hepatology 48 (January 2008): S353. http://dx.doi.org/10.1016/s0168-8278(08)60946-0.

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Flekhter, O. B., L. T. Karachurina, L. R. Nigmatullina, et al. "Synthesis and hepatoprotector activity of 2-arylidene methylbetulonate derivatives." Pharmaceutical Chemistry Journal 34, no. 2 (2000): 45–47. http://dx.doi.org/10.1007/bf02524355.

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