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Salahshour, Babak, Sajjad Sadeghi, Hajar Nazari, and Kambiz Soltaninejad. "Determining Undeclared Synthetic Pharmaceuticals as Adulterants in Weight Loss Herbal Medicines." International Journal of Medical Toxicology and Forensic Medicine 10, no. 1 (2020): 26253. http://dx.doi.org/10.32598/ijmtfm.v10i1.26253.
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Background: The popularity and use of herbal medicines and supplements are growing worldwide. Herbal anti-obesity products have been considered as suitable alternatives to synthetic pharmaceuticals as they are introduced as harmless natural products. However, some manufacturers often add undeclared synthetic pharmaceuticals to the anti-obesity herbal medicine products to improve their efficacy and potency. The present study aimed to analyze herbal weight loss products collected from the drug market in Bojnurd City, Iran.Methods: Ninety-six herbal drug samples, as weight loss products, were obtained from herb shops and pharmacies in Bojnurd City, Iran. All samples were analyzed to detect undeclared active pharmaceutical ingredients using High-Performance Liquid Chromatography with Diode Array Detector (HPLC-DAD) and Gas Chromatography-Mass Spectrometry (GC-MS) techniques.Results: Caffeine, trimethoxyamphetamine, and vitamin E were identified in herbal weight loss products. Caffeine was detected in 21.8% of the obtained samples, as the most common undeclared active pharmaceutical adulterant. Conclusion: Undeclared active pharmaceutical ingredients in herbal weight loss products could threaten patients’ health. Thus, it is necessary to create awareness through health authorities in this regard.
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Shiri-Ghaleh, Vida, Mehrdad Moradi, and Kambiz Soltaninejad. "Determination of Common Pharmaceutical Adulterants in Herbal Medicinal Products Used in the Treatment of Opioid Addiction." International Journal of Medical Toxicology and Forensic Medicine 9, no. 4 (2019): 243–54. http://dx.doi.org/10.32598/ijmtfm.v9i4.26310.
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Background: Opioid addiction is a serious and growing global concern. Recently, herbal medicine has been popular for the treatment of opioid abusers worldwide. Unfortunately, the adulteration of herbal remedies with undeclared synthetic pharmaceuticals has been reported. In Iran, there are few reports on the adulteration of herbal remedies by synthetic pharmaceuticals sold as opioid addiction treatment. The aim of this study was to analyze herbal products used in opioid addiction treatment for the identification of synthetic pharmaceuticals as adulterants in the remedies.Methods: Forty commonly-used handmade herbal products for the treatment of opioid addiction were collected from herbal shops in Kermanshah (western area of Iran). After organoleptic examinations, the samples were prepared and analyzed by high-performance liquid chromatography and gas chromatography-mass spectrometry for detecting probable synthetic pharmaceutical adulterants.Results: The chromatographic analysis of the samples showed that 90% of the products had at least one undeclared pharmaceutical ingredient as an adulterant. The majority of the samples (n=19, 47.5%) had only one undeclared pharmaceutical. Diphenoxylate (n=24, 39.3%), tramadol (n=16, 26.2), methadone (n=8, 13.2%), and the combination of these drugs were reported as common adulterants. We detected the presence of buprenorphine and sildenafil as adulterating agents in the herbal formulations for the first time.Conclusion: According to the presence of undeclared synthetic pharmaceuticals in opioid addiction herbal products, as well as their threats to public health, awareness, in this case, is necessary.
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Kim, Hobeom, Sungyong Kim, and Hyeun-kyoo Shin. "A Study on the Status of Traditional Herbal Medicine Products in the Korean Pharmaceutical Industry Over the Past 40 Years." Journal of Korean Medicine 46, no. 2 (2025): 190–205. https://doi.org/10.13048/jkm.25028.
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Objectives: This study aimed to investigate and analyze long-term trends in the production of traditional herbal medicine products within the Korean pharmaceutical industry. The findings are intended to provide foundational data for policy development to revitalize the herbal medicine market.Methods: Production and market data for traditional herbal medicine products in the Korean pharmaceutical industry over the past 40 years (1980–2020) were collected and analyzed. The primary data source, obtained from the official "Production Performance Table of Pharmaceutical Products, etc." (Excel electronic data), was analyzed using Tableau software.Results: The total production value of traditional herbal medicine products in Korea reached 360.8 billion KRW in 2023. Of this, the four herbal medicine products—Woohwangchungsim-won, Kyeongok-go, Gongjin-dan, and Ssanghwa-tang—accounted for 197.9 billion KRW (54.8%). Insurance-covered single (67 types) and mixed (42 types) herbal extracts contributed 49.8 billion KRW (13.8%), while other herbal medicine products comprised 113.1 billion KRW (31.3%). Over the past four decades, the herbal medicine industry and its product indicators have remained largely stagnant without significant growth. However, there has been an increase in the production of insurance-covered herbal medicine products and a noticeable shift in preferred dosage forms from dried extracts to soft extracts. Currently, the market is dominated by the aforementioned four herbal medicine products.Conclusions: Despite remarkable advances in the Korean pharmaceutical industry overall, the traditional herbal medicine sector has remained stagnant. The market size has lingered below 400 billion KRW for an extended period, and a few specific herbal medicines account for more than half of total sales. The complexity of professional roles and detailed pharmaceutical classifications has led to excessive social costs associated with herbal medicine-based pharmaceuticals. Without innovative institutional reforms, the prospects of the herbal pharmaceutical industry and market remain uncertain.
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Holovach, A. R., S. V. Kovalov, N. M. Deviatkina, V. M. Kovalov, D. V. Karamyshev, and V. O. Korshenko. "STANDARDIZATION OF RAW MATERIALS OF ERIGERON ANNUUS (ANNUAL FLEABANE)." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 25, no. 1 (2025): 150–58. https://doi.org/10.31718/2077-1096.25.1.150.
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Medicinal plant raw materials and their derived preparations are widely used by leading pharmaceutical manufacturers and constitute a significant share of the global pharmaceutical market. Standardization plays a crucial role as a quality control mechanism for herbal medicinal products. The term “standardization’ refers to all measures taken during the production process and quality control to ensure the consistent quality of herbal preparations. To obtain high-quality herbal medicines, it is essential to oversee all stages of production, starting from proper cultivation and identification of medicinal plants, considering the season and region of collection, and concluding with the extraction and purification of plant-based preparations. Herbal medicines and finished plant-based pharmaceutical products have been widely used for thousands of years. In recent decades, the growth in the production of herbal medicinal preparations and the increasing popularity of phytotherapy have significantly expanded the share of plant-based pharmaceuticals in the global market. Today, herbal medicines account for 70-95% of the global pharmaceutical industry. According to the World Health Organization (WHO), approximately 80% of the world's population relies on herbs and other traditional medicinal products to meet their primary healthcare needs.
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Alqahtani, Falah Shynan, Zainab Ibrahim Alshabeb, Meshal Muflih Aljohani, Nahla Faleh Alotaibi, and Abdulrahman Buzaya Alshammari. "Pharmaceutical Analysis and Standardization of Herbal Medicines." Journal of Advances and Scholarly Researches in Allied Education 21, no. 1 (2024): 386–405. https://doi.org/10.29070/2415sk26.
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This paper provides a comprehensive overview of the criteria used to test and standardize medicinal plants and components in the pharmaceutical sector. Natural or herbal therapies are becoming increasingly popular as alternatives to commercially produced drugs due to their low risk of side effects. As herbal therapeutic items become more popular, concerns regarding their effectiveness, safety, and quality arise. These problems stem from the lack of herbal therapy standardization criteria. To maintain quality, herbal medicinal plant components must be standardized using rigorous standards and analytical methods. Herbal treatments are tested and standardized using several physical, chemical, and biological approaches. These methods determine if herbal plant materials and formulations are safe, pure, and effective and constitute the basis of quality control. Analytical methods like TLC, HPTLC, GC, LC-MS, UPLC, UHPLC, UPLC-MS, and UHPLC-MS are used to quantify herbal drugs and their formulations. This assessment emphasizes these methods. Standardized assessment criteria are necessary to guarantee herbal medical product active ingredients are dependable and effective. These analytical methods can standardize and test herbal medicines. This preserves herbal medicine quality and reliability. If these guidelines are followed, herbal medicines will meet safety, efficacy, and consistency criteria.
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Lu, Chia-Ming, Mei-Ling Hou, Lie-Chwen Lin, and Tung-Hu Tsai. "Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/952796.
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This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM) and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.
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Sadeghi, Sajjad. "Investigating the Detection of Undeclared Cyproheptadine in Weight Gain Herbal Supplements, Creajensing." International Journal of Medical Toxicology and Forensic Medicine 14, no. 02 (2024): 43922. http://dx.doi.org/10.32598/ijmtfm.v14i02.43922.
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Background: Nowadays many people depend on herbal medicine for their healthcare needs; however, handmade herbal drugs are not screened for efficacy and safety. Undeclared active pharmaceutical ingredients have been detected in herbal medicine, even if there are claims to be natural. This study determines the undeclared active pharmaceutical ingredients in a weight gain herbal supplement collected from an Iranian online herbal shop. Methods: One packet of herbal supplement (containing 45 tablets), advised as a weight gain product, was gathered from an online herbal shop in Iran. The sample was analyzed to detect undeclared active pharmaceutical ingredients using gas chromatography/mass spectrometry instrument, based on Iranian forensic standard operating procedures 920118-2655. Results: The cyproheptadine was detected in this herbal supplement at a concentration higher than the therapeutic dose. Conclusion: Although synthetic drugs cannot be produced except by permission of the licensing authorities, there is no regulation for herbal supplement production in Iran. Therefore, herbal supplements’ serious quality and safety concerns must be assured for patients’ health.
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Sharma, Diksha, Veerta Sharma, Gaaminepreet Singh, Thakur Gurjeet Singh, and Amarjot Kaur Grewal. "Mechanistic role of herbals as alternative therapy for epilepsy." Journal of Pharmaceutical Technology, Research and Management 10, no. 1 (2022): 13–20. http://dx.doi.org/10.15415/jptrm.2022.101003.
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Botanicals and herbs have been used by people with epilepsy for ages in various cultures across the world. Patients in both developing and developed nations are currently using herbal remedies to manage seizures or side effects from antiepileptic medicines (AEDs). The deleterious effects of AED medication have a greater impact on the patient’s life than seizures. Alternative remedies should be used to treat and manage epilepsy because synthetic pharmaceuticals have risks. Epilepsy may be managed and treated using herbal medicines that have fewer negative effects than pharmaceutical medications. Therefore, the current review discusses about the herbal drugs used in treatment of epilepsy.
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Bilia, Anna Rita. "1968–2008: 40 Years of Franco F. Vincieri's Natural Products Research." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301201.
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This paper presents an overview of Prof. Vincieri's accomplishments in his career as a researcher in the field of pharmacognosy (pharmaceutical biology), analytical phytochemistry and pharmaceutical technology applied to herbal drug preparations at the Department of Pharmaceutical Sciences of the University of Florence. This article is a recognition of his valuable contributions to these research fields, especially for his outstanding and innovative interdisciplinary studies on the quality control of herbal drugs, herbal drug preparations, herbal medicinal products, botanical food supplements, and some “special foods” such as grapes, wines, olives and olive oil.
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Deepali, S. Suryavanshi* Ajit Ashok Naik Anjum Gafar Bairagdar Aditi Rajgonda Patil Snehal P. Bongarde. "Pharmaceutical Preparation And Evaluation Of Herbal Cold Cream." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 663–69. https://doi.org/10.5281/zenodo.11611992.
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cold cream is used for deep moisturization and allow to remove waste substance from pores and cools the body. Herbal cold cream involve the pure and natural ingredient without any additives in their preparation. The aim of project is Pharmaceutical Preparation and Evaluation of Herbal Cold Cream. Herbal ingredients such as Mint, Honey, Coconut oil, Turmeric powder, Rose water etc are used. All ingredients have any specific property to protect skin from any harmful effect. Main herbal ingredient is Mint because mint have specific cooling effect. To evaluate cream different evaluation parameter used such as Irritation test, Physical evaluation, Washability, pH, Spread ability test etc. Herbal cold cream provide significant effect to the skin.
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Moulin, Anne-Marie. "The herbal pharmaceutical industry in India." médecine/sciences 32, no. 10 (2016): 895–97. http://dx.doi.org/10.1051/medsci/20163210024.
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Bhattacharya, Rupa, M. Pharm, Shubham Borkar, and Ayasha P. Sathawane. "Current Review on Herbal Pharmaceutical Binders." Research Journal of Pharmaceutical Dosage Forms and Technology 11, no. 4 (2019): 288. http://dx.doi.org/10.5958/0975-4377.2019.00048.x.
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Kalyani, Avhale* Dr. Kawade Rajendra M. Mayuri Lodha Shivani Matsagar Arti Tupe. "Solubility Modification of Phytochemicals via Pharmaceutical Cocrystal." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 587–97. https://doi.org/10.5281/zenodo.14278837.
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Pharmaceutical cocrystal is an approach to physicochemical and mechanical properties of a drug substance the cocrystal are composed of conformer and API which are mainly used for solubility and dissolution mechanical properties and stability of drug. this review will provide information about what is cocrystal, how they are prepared, what is the advantages behind the pharmaceutical cocrystal preparation, the whole cocrystal development pathway in which all the steps involved in the cocrystal formation from selection of API to the after preparation scale up process are given. the concept of multidrug cocrystal are given, then the different method of crystallization the main focused on this review on herbal cocrystal it provide information about herbal cocrystal. Case studies of varies herbal cocrystal have been discussed. The chart of herbal drug along with their conformer and the method of preparation and application of cocrystal. we can achieve successful drug delivery through co-crystallization. the pharmaceutical industry will beneficial through successful development of co-crystallization of herbal drug substance.
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Alexieva, Iordanka N., Aneta T. Popova, and Dasha Sp Mihaylova. "Trends in herbal usage – a survey study." Food Research 4, no. 2 (2019): 500–506. http://dx.doi.org/10.26656/fr.2017.4(2).346.
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Folk medicine is quite common for primary health care in Bulgaria, and the tradition of plant usage is of importance for the development of pharmaceutical formulations. The objective of this study was to provide up-to-date information regarding trends in herbal usage among citizens in the city of Plovdiv, Bulgaria. The study involved 114 respondents for a period of 60 calendar days in 2018. Chamomile (Matricaria recutita L.) and thyme (Thymus vulgaris L.) were the most popular plants among the respondents. The common cold is the most frequent example for seeking herbals and other botanicals. Herbal teas are most preferred when it comes to daily consumption. Answers also revealed plants used in households; reasons for herbal consumption, and opinions on common statements concerning herbal stereotypes.
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Lacatusu, Ioana, Teodora Alexandra Iordache, Mirela Mihaila, Dan Eduard Mihaiescu, Anca Lucia Pop, and Nicoleta Badea. "Multifaced Role of Dual Herbal Principles Loaded-Lipid Nanocarriers in Providing High Therapeutic Efficacity." Pharmaceutics 13, no. 9 (2021): 1511. http://dx.doi.org/10.3390/pharmaceutics13091511.
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Although many phytochemicals have been used in traditional medicine, there is a great need to refresh the health benefits and adjust the shortcomings of herbal medicine. In this research, two herbal principles (Diosgenin and Glycyrrhiza glabra extract) coopted in the Nanostructured Lipid Carriers have been developed for improving the most desirable properties of herbal medicine—antioxidant and anti-inflammatory actions. The contribution of phytochemicals, vegetable oils and of lipid matrices has been highlighted by comparative study of size, stability, entrapment efficiency, morphological characteristics, and thermal behavior. According to the in vitro MTS and RTCA results, the dual herbal-NLCs were no cytotoxic toward endothelial cells at concentrations between 25 and 100 µg/mL. A rapid release of Glycyrrhiza glabra and a motivated delay of Diosgenin was detected by the in vitro release experiments. Dual herbal-NLCs showed an elevated ability to annihilate long-life cationic radicals (ABTS•+) and short-life oxygenated radicals (an inhibition of 63.4% ABTS•+, while the ability to capture radical oxygen species reached 96%). The production of pro-inflammatory cytokines was significantly inhibited by the newly herbals-NLC (up to 97.9% inhibition of TNF-α and 62.5% for IL-6). The study may open a new pharmacotherapy horizon; it provides a comprehensive basis for the use of herbal-NLC in the treatment of inflammatory diseases.
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Shalal, Omar Sadik, and Ani-Simona Sevastre. "Evaluation of cytotoxicity and apoptotic effects of Catharanthus roseus on the human lung cancer cell lines CaLu-6." Revista Romana de Medicina de Laborator 32, no. 2 (2024): 177–84. http://dx.doi.org/10.2478/rrlm-2024-0017.
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Abstract Background Lung cancer is ranked as the fourth global important cause of cancer related deaths. Despite remarkable advances in drug design, the pharmaceutical industry grapples with significant scientific and financial challenges. While recent strides have been made in the development of chemically synthesized pharmaceutical drugs, nature continues to serve as a primary source of bioactive compounds. The synthesis and assessment of natural herbal remedies have been a focal point of cancer therapy research for many years. The synthesis and evaluation of natural herbal remedies have been a primary research for many years in cancer therapy and the obtained results support the continuous development of novel plant-derived products, mainly because natural herbal remedies have several benefits compared to traditional chemical pharmaceuticals. Methods This study aims to evaluate the potential cytotoxicity of Catharanthus roseus methanolic extract on Human Lung Cancer Cell Lines (CaLu-6). The evaluation was performed using apoptotic and membrane depolarization assays. In addition, the real time gene expression was used for assessing the levels of mRNA. Results The results demonstrated the possible and positive anticancerous activity of Catharanthus roseus methanolic extract compared to the positive control (p<0.05). Conclusions Our results support the ongoing exploration of novel plant-derived products for cancer therapy, emphasizing the benefits offered by natural herbal remedies over traditional chemical pharmaceuticals. Further research in this direction could lead to the development of more effective and less toxic treatments for lung cancer.
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Ivan, Bezruk, Georgiyants Victoriya, and Ivanauskas Liudas. "Comparison of components profile in herbal raw material, extract and pharmaceuticals of Hedera Helix." ScienceRise: Pharmaceutical Science, no. 4(26) (August 31, 2020): 36–39. https://doi.org/10.15587/2519-4852.2020.210768.
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<strong>The aim. </strong>To investigate both the profile of components and possible difference among herbal raw materials, semi-products and pharmaceuticals of Hedera helix for determination of main standartisation markers. <strong>Materials and methods. </strong>Investigation of components profile has been performed using the Shimadzu Nexera X2 chromatographic system coupled with a diode-area detector. The ACE C 18 column (250 mm × 4.6 mm with particle size 5 mm) was used for the separation of components. 0.1 % acetic acid and acetonitrile were used as mobile phase A and B, respectively. Studies have been performed on the leaves, dry extract and capsules of H. helix. <strong>Results. </strong>The determined profile had no significant variation among samples. It has been presented by 19 various components, such as phenolic acids, flavonoids and triterpene saponins. However, kaempferol, nicotiflorin and t-cinnamic acid were not found in the leaf raw material. Hederacoside C might be highlighted as the main marker of raw materials and products of H. helix due to its significant amount in comparison to other components. Its amount was in the range of 64,80 % up to 71,46 % of the total content of components. Moreover, according to some pharmacological studies, hederacoside C is responsible for pharmaceutical usage of H. helix pharmaceutics. Nevertheless, it is not recommended to standardize the plant-based medicines by one marker, since the pharmaceutical activity of such dosage forms is defined by synergism action of all constituents. Except for hederacoside C significant amounts in comparison to other components were found for chlorogenic acid and 4,5-dicaffeoylquinic acid about 5 % and 3 % respectively. Though the latter was found in small concentrations in leaves (0,058 %). This sample had a much higher amount of 3,5-dicaffeoylquinic acid, but in the case of extract and capsules, its content was lower 1,55 % and 0,66 % respectively. Thus, chlorogenic acid has been chosen as a second marker due to its high concentration in all samples and some pharmaceutical activities, such as antioxidant and anti-inflammatory effects. <strong>Conclusions. </strong>It was found, that standartisation of H. helix products is preferably to perform with determination both hederacoside C and chlorogenic acid. These components were dominant among all components; besides they possess a wide range of pharmaceutical effects. Hence, quantification of hederacoside C and chlorogenic acid is necessary to ensure the high quality of H. helix pharmaceuticals.
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Saju, Fels, and Chinju M. Sivaraman. "Scope of herbal mucilage in pharmaceutical formulations. A review." Herba Polonica 67, no. 1 (2021): 46–57. http://dx.doi.org/10.2478/hepo-2021-0001.
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Summary The aim of the article was to obtain maximum information about plant mucilage, its sources and applications in the pharmaceutical industry. This study focuses on the scientific articles and books available in Internet resources and college library that deal with the sources, applications, extraction and isolation of plant mucilage. Mucilage is obtained mainly from plant sources and can be isolated easily. Due to the low cost, easy availability, non-toxicity, non-irritancy, and biocompatibility, mucilage is of great demand in the field of pharmaceuticals. Hibiscus rosa-sinensis L., Trigonella foenum-graecum L., Abelmoschus esculentus L, Plantago ovata Forssk. and Aloe barbadensis L. are some common sources of mucilage. The isolation methods vary depending on the part of the plant where mucilage is present. It is commonly used as gelling agent, suspending agent, binder, and disintegrant. Since it is hydrophilic in nature, chances of deterioration are higher. In this review, different mucilage sources and their isolation methods are discussed in detail. Mucilage is used as excipient in many formulations of tablets, suspensions, gels, etc. The study explores the potential of plant mucilage as an excipient in pharmaceutical formulations. The biodegradable and biocompatible properties of this inexpensive excipient make it more favourable for the newer formulation development.
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Rojas, Patricia, Elizabeth Ruiz-Sánchez, Carolina Rojas, et al. "Human Health Risk Assessment of Arsenic and Other Metals in Herbal Products Containing St. John’s Wort in the Metropolitan Area of Mexico City." Toxics 11, no. 9 (2023): 801. http://dx.doi.org/10.3390/toxics11090801.
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Consumption of St. John’s wort plant is high worldwide due to its various medicinal properties. However, herbal products containing St. John’s wort may be contaminated with toxic metals. This is often related to contamination of both water and the atmosphere, lack of proper cultivation methods, and inadequate plant storage conditions, as well as a lack of stricter sanitary supervision. A safety assessment of copper (Cu), lead (Pb), cadmium (Cd) and arsenic (As) content in 23 products containing St. John’s wort (pharmaceutical herbal products, food supplements and traditional herbal remedies) sold in the metropolitan area of Mexico City was conducted. The analysis of metals was determined using a graphite-furnace atomic absorption spectrometer. All herbal products were contaminated with Cu, Pb, Cd and As. The pharmaceutical herbal items showed less contamination by metals. The daily human intake (DHI) values for Pb exceeded the permissible limits in the group of traditional herbal remedies. The DHI calculation for As exceeded the permitted intake values for all items in the group of traditional herbal remedies, five food supplements and one pharmaceutical herbal product. The hazard indicator calculation of the non-carcinogenic cumulative risk values for traditional herbal remedies was greater than 1, suggesting a risk to human health.
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Sitre, S. R., and S. Satyanarayan. "Toxicity evaluation of herbal pharmaceutical wastewater to the freshwater crustacean Cypris spp." Water Science and Technology 63, no. 7 (2011): 1441–45. http://dx.doi.org/10.2166/wst.2011.327.
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In India a large number of pharmaceutical industries are manufacturing drugs of complex type subsequently producing huge quantities of wastewaters. The herbal pharmaceutical industries are one of them which manufacture various herbal medicines from natural products and certain chemicals and metal combinations. During their manufacturing process a large number of toxicants enter the watercourse harming the biota of the receiving water bodies. Zooplankton organisms being at the base of the food chain if affected, will subsequently affect the fisheries potential at large, harming the interest of man. Keeping this point in view a herbal pharmaceutical manufacturing industry based at Nagpur was selected for investigation with respect to assessing its toxic effect on the freshwater crustacean Cypris spp. during short duration toxicity tests. This research paper discusses in detail the bioassay evaluation of raw, neutralized and physico-chemically treated herbal pharmaceutical effluent for arriving at a concentration safe for the Cypris spp.
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Mustarichie, Resmi, Danni Ramdhani, and Wiwiek Indriyati. "ANALYSIS OF FORBIDDEN PHARMACEUTICAL COMPOUINDS IN ANTIRHEUMATIC JAMU." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 98. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16101.
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Objective:To determine forbidden (by law) pharmaceutical compounds in antirheumatic jamu.)Methods: Analysis of forbidden pharmaceutical ingredients into jamu was carried out by using the color reaction, thin layer chromatography and densitometry. Color reactions included organoleptic, solubility test and the color reaction, TLC using a stationary phase of silica gel GF 254 and a mobile phase of chloroform; acetone (80:20) was then measured with a densitometer.Results: Found from 7 herbal anti-rheumatic known in the market, three of which were synthetic compounds containing paracetamol and dexamethasone additions on one of them. Conclusion: There was a synthetic drug that was added to the herbal medicine namely jamu sold in the community The obtained results suggest that the authorities more intensively to monitor the manufacture and distribution of jamu and herbal medicines Keywords: AntirheumaticJamu, herbal medicine, TLC, Densitometer, paracetamol, dexamethasone
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Supandi, Denny, and Afriyeni Afriyeni. "The Influence of Financial Performance Q3 2023 Through Net Profit Margin (NPM), ROA and ROE on the Decrease in Share Prices of PT Herbal Medicine and Pharmaceutical Industry Sido Muncul Tbk." International Journal of Social Service and Research 3, no. 12 (2023): 3188–98. http://dx.doi.org/10.46799/ijssr.v3i12.636.
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The purpose of this study is to determine the effect of Net Profit Margin (NPM), Return On Asset (ROA), and Return On Equity (ROE) on the decline in share prices at PT. Sido Muncul Tbk. Herbal and Pharmaceutical Industry which is listed on the Indonesia Stock Exchange for the 2023 period. This type of research is descriptive quantitative. The population in the study is the financial statements and stock prices of PT. Sido Muncul Tbk's Herbal and Pharmaceutical Industry for the 2023 period. In this study, purposive sampling techniques were used, the samples in this study were financial statements and stock prices for the quarter of 2023. Researchers use documentation observation techniques, analytical tools used using multiple linear regression analysis. The results stated that partially Net Profit Margin (NPM) and Return On Asset (ROA) did not have a significant effect on the decline in share price at PT. Sido Muncul Tbk. Herbal and Pharmaceutical Industry While Return On Equity (ROE) has a significant effect on the decline in share price at PT. Sido Muncul Tbk. Herbal and Pharmaceutical Industry Simultaneously Net Profit Margin (NPM), Return On Asset (ROA), and Return On Equity (ROE) have a significant effect on the decline in share price at PT. Herbal and Pharmaceutical Industry Sido Muncul Tbk.
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Tyler, Varro E. "Herbal Remedies." Journal of Pharmacy Technology 11, no. 5 (1995): 214–20. http://dx.doi.org/10.1177/875512259501100510.
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Objective: To provide an overview of basic information required by pharmacists to advise patients on the proper use of selected herbs and phytomedicines (“dietary supplements”) as therapeutic agents. Data Sources: The vast literature on this topic in the English, German, and French languages has been researched by the author over a period of many years. Databases that were used include NAPRALERT and MEDLINE. Study Selection: Articles and books dealing with the current popularity of botanical medicine and with laws and regulations covering so-called dietary supplements, as well as information on selected toxic herbs and a few of the most popular beneficial herbs used for treating common ailments and syndromes. Data Synthesis: Studies suggest that many herbal products currently available are both safe and effective drugs. A few products on the US market are definitely unsafe for human consumption and use. Conclusions: The increasing popularity of botanicals, coupled with regulations that prohibit definitive labeling, requires pharmacists to acquire accurate information based on scientifically and clinically acceptable data to advise patients on their use. Useful remedies for several common ailments and information concerning their safety and usefulness provide a starting point for an understanding of this complex field.
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Petrović, Silvana. "Herbal and traditional Herbal Medicinal Products, EU Herbal monographs and EU list." Arhiv za farmaciju 69, no. 4 (2019): 221–69. http://dx.doi.org/10.5937/arhfarm1904221p.
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Fecka, Izabela. "Development of Chromatographic Methods for Determination of Agrimoniin and Related Polyphenols in Pharmaceutical Products." Journal of AOAC INTERNATIONAL 92, no. 2 (2009): 410–18. http://dx.doi.org/10.1093/jaoac/92.2.410.
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Abstract Thin-layer chromatography (TLC) and liquid chromatography (LC) methods were developed for the qualitative and quantitative determination of agrimoniin, pedunculagin, ellagic acid, gallic acid, and catechin in selected herbal medicinal products from Rosaceae: Anserinae herba, Tormentillae rhizoma, Alchemillae herba, Agrimoniae herba, and Fragariae folium. Unmodified silica gel (TLC Si60, HPTLC LiChrospher Si60) and silica gel chemically modified with octadecyl or aminopropyl groups (HPTLC RP18W and HPTLC NH2) were used for TLC. The best resolution and selectivity were achieved with the following mobile phases: diisopropyl etheracetoneformic acidwater (40 30 20 10, v/v/v/v), tetrahydrofuranacetonitrilewater (30 10 60, v/v/v), and acetoneformic acid (60 40, v/v). Concentrations of the studied herbal drugs were determined by using a Chromolith Performance RP-18e column with acetonitrilewaterformic acid as the mobile phase. Determinations of linearity, range, detection and quantitation limits, accuracy, precision, and robustness showed that the HPLC method was sufficiently precise for estimation of the tannins and related polyphenols mentioned above. Investigations of suitable solvent selection, sample extraction procedure, and short-time stability of analytes at storage temperatures of 4 and 20C were also performed. The percentage of agrimoniin in pharmaceutical products was between 0.57 and 3.23.
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Aziz Ur Rahman, Muhammad Owais, and Irfan Ansari. "Heavy metals assay of herbal pharmaceutical effluent." International Journal of Biological and Pharmaceutical Sciences Archive 1, no. 2 (2021): 161–66. http://dx.doi.org/10.30574/ijbpsa.2021.1.2.0037.
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Environmental pollution particularly from heavy metals in effluent is the gravest problem in developing countries like Pakistan. Effluents of Herbal Pharmaceutical are waste water generated during Herbal Medicines manufacturing process. When these effluents deprived of appropriate treatment are released directly into the environment, results in potential adverse effects on human health and the environment. This research work examined the heavy metals parameters of effluents discharged by Herbal pharmaceutical industry in Karachi, Pakistan. In all, 08 parameters were studied. These include Cr, Mn, Fe, Co, Ni, Cu, Ag and Pb. The study revealed that ranges of Ag and Fe were exceeding the allowable limit of WHO (World Health Organization) and NEQS (National Environmental Quality Standards). This calls for an immediate use of latest treatment plants to decrease the harmfulness that results from waste water.
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Jensen, Clyde B. "Clinical Trials of Herbal and Pharmaceutical Products." Alternative and Complementary Therapies 4, no. 1 (1998): 30–35. http://dx.doi.org/10.1089/act.1998.4.30.
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Suthar, Surindra, and Deepika Singh. "Phytotoxicity of composted herbal pharmaceutical industry wastes." Environmental Science and Pollution Research 19, no. 7 (2012): 3054–59. http://dx.doi.org/10.1007/s11356-012-0985-y.
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Singh, Deepika, and Surindra Suthar. "Vermicomposting of herbal pharmaceutical industry solid wastes." Ecological Engineering 39 (February 2012): 1–6. http://dx.doi.org/10.1016/j.ecoleng.2011.10.015.
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Biagi, Marco, Rita Pecorari, Giovanni Appendino, et al. "Herbal Products in Italy: The Thin Line between Phytotherapy, Nutrition and Parapharmaceuticals; A Normative Overview of the Fastest Growing Market in Europe." Pharmaceuticals 9 (October 29, 2016): 65. https://doi.org/10.3390/ph9040065.
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The Italian herbal products market is the most prosperous in Europe. The proof is represented by the use of these products in several marketing categories, ranging from medicine to nutrition and cosmetics. Market and legislation in Italy are at the same time cause and consequence of this peculiar situation. In fact, the legislation on botanical food supplements in Italy is very permissive and at the same time the market shows an overall satisfaction of users and strong feedback in terms of consumption, which brings a widening use of medicinal plants, formerly the prerogative of pharmaceuticals, to other fields such as nutrition. This review summarizes the market and normative panorama of herbal products in Italy, highlighting the blurred boundaries of health indications, marketing authorizations and quality controls between herbal medicines and non pharmaceutical products, such as food supplements, cosmetics and other herbal-based “parapharmaceuticals”.
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Damien, Barikissou Georgia, Carine Baxerres, Edwige Apetoh, and Hesran Jean-Yves Le. "Between traditional remedies and pharmaceutical drugs: prevention and treatment of "Palu" in households in Benin, West Africa." BMC Public Health 20, no. 1 (2020): 1425. https://doi.org/10.1186/s12889-020-09479-7.
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<strong>Background: </strong>In Benin, malaria clinical cases, including the larger popular entity called "Palu" are evoked when people get fever. "Palu" is often self-diagnosed and self-medicated at home. This study aimed to describe the use of herbal medicine, and/or pharmaceutical medicines for prevention and treatment of malaria at home and the factors associated with this usage.<strong>Methods: </strong>A cross-sectional survey was conducted in Benin in an urban and in a rural area in 2016. Around 600 households in each place were selected by using a random sampling of houses GPS coordinates of the families. The association between socio demographic characteristics and the use of herbal medicine was tested by using logistic regression models.<strong>Results: </strong>In Cotonou (urban), 43.64% of households reported using herbal or pharmaceutical medicine to prevent "Palu", while they were 53.1% in Lobogo (rural). To treat "Palu" in Cotonou, 5.34% of households reported using herbal medicine exclusively, 33.70% pharmaceutical medicine exclusively and 60.96% reported using both. In Lobogo, 4% reported using herbal medicine exclusively, 6.78% pharmaceutical medicine exclusively and 89.22% reported using both. In Cotonou, the factors "age of respondent", "participation to a traditional form of savings" and "low socioeconomic level of the household" were associated with the use of herbal medicine.<strong>Conclusions: </strong>This study shows the strong use of herbal medicine to prevent "Palu" or even treat it, and in this case it is mostly associated with the use of pharmaceutical medicine. It also highlights the fact that malaria control and care seeking behaviour with herbal medicine remain closely linked to household low-income status but also to cultural behaviour. The interest of this study is mostly educational, with regards to community practices concerning "Palu", and to the design of adapted behaviour change communication strategies. Finally, there is a need to take into account the traditional habits of populations in malaria control and define a rational and risk-free use of herbal medicine as WHO-recommended.
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Rojas, Patricia, Elizabeth Ruiz-Sánchez, Camilo Ríos, Ángel Ruiz-Chow, and Aldo A. Reséndiz-Albor. "A Health Risk Assessment of Lead and Other Metals in Pharmaceutical Herbal Products and Dietary Supplements Containing Ginkgo biloba in the Mexico City Metropolitan Area." International Journal of Environmental Research and Public Health 18, no. 16 (2021): 8285. http://dx.doi.org/10.3390/ijerph18168285.
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The use of the medicinal plant Ginkgo biloba has increased worldwide. However, G. biloba is capable of assimilating both essential and toxic metals, and the ingestion of contaminated products can cause damage to health. The aim of this study was to investigate the safety of manganese (Mn), copper (Cu), lead (Pb), arsenic (As), and cadmium (Cd) in 26 items containing Ginkgo biloba (pharmaceutical herbal products, dietary supplements, and traditional herbal remedies) purchased in the metropolitan area of Mexico City. Metal analysis was performed using a graphite furnace atomic absorption spectrometer. All of the products were contaminated with Pb, 54% of them with As, and 81% with Cd. The lowest values of Pb, As, and Cd were detected in pharmaceutical herbal products > dietary supplements > traditional herbal remedies. The daily intake dose (DID) of pharmaceutical herbal products was within the established limits for the five metals. Dietary supplements and traditional herbal remedies exceeded the DID limits for Pb. The hazard quotients estimation and non-carcinogenic cumulative hazard estimation index for Mn, As, and Cd indicated no human health risk. Our results suggest that products containing G. biloba for sale in Mexico are not a health risk.
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Ikram, Muhammad, Ali Haider, and Urooj Fatima. "Pharmaceutical Activity of Medicinal Plant Amaranthus viridis Linn. Due to Its Chemical Constituents: A Review." BIOEDUSCIENCE 7, no. 2 (2023): 143–48. http://dx.doi.org/10.22236/jbes/12089.
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Background: Amaranthus viridis, a herbal plant belonging to the family Amaranthaceae, has gained significant attention in the field of traditional medicine due to its rich chemical composition. This plant is known to contain various bioactive components that contribute to its pharmaceutical value. With its extensive range of chemical compounds, Amaranthus viridis has found applications in therapeutic, pharmaceutics, and cosmetic industries. In this study, we aim to explore the medicinal potential of Amaranthus viridis and investigate its various pharmaceutical activities. Methods: The process of writing this review involved conducting comprehensive electronic research using reputable sources, including international and national article databases, along with books accessed through platforms like Google Scholar, PubMed, IEEE Xplore, ScienceDirect and others. The gathered data is subsequently analyzed, followed by employing synthetic approaches with narrative methods to derive meaningful conclusions and interpretations. Results: Amaranthus viridis displays potent antioxidant and anti-inflammatory properties, attributed to its rich composition of flavonoids, cardiac glycosides, and zinc. Its diverse pharmaceutical activities make it a promising contender for medicinal use, addressing labor pain, skin conditions like eczema and psoriasis, and respiratory issues, while also exhibiting antimicrobial effects against bacteria, fungi, and parasites. It can be accomplished by Extraction with solvent, Phytochemical screening and Isolation and purification. Conclusion: Amaranthus viridis, a herbal plant, shows significant potential in therapeutic, pharmaceutics, and makeup industries. Its bioactive compounds, including flavonoids, cardiac glycosides, and zinc, contribute to its diverse pharmaceutical activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, antidiabetic, and antihelmintic properties.
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Jairoun, Ammar A., Sabaa Saleh Al-Hemyari, Moyad Shahwan, and Sa’ed H. Zyoud. "Adulteration of Weight Loss Supplements by the Illegal Addition of Synthetic Pharmaceuticals." Molecules 26, no. 22 (2021): 6903. http://dx.doi.org/10.3390/molecules26226903.
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Weight loss supplements that have illegal additives of pharmaceutical drugs or analogues have additional health risks, and customers may not be aware of what they are taking. This research is an essential investigation and quantification of illegally added pharmaceuticals or prescription medications, specifically fluoxetine, phenolphthalein, and sibutramine, in herbal weight loss supplements offered for sale in the United Arab Emirates (UAE). In this case, 137 weight loss supplements were collected and analyzed in this study. Reversed-phase high-performance liquid chromatography with UV absorption detection coupled to tandem mass spectrometry (RP-HPLC-MS/MS) analyses were used to determine the presence of the pharmaceutical chemicals. Among the weight loss supplements, 15.3% (95% CI: 9.2–21.4) contained undeclared sibutramine, 13.9% (95% CI: 8.01–19.7) contained undeclared phenolphthalein, and 5.1% (95% CI: 1.4–8.8) contained undeclared fluoxetine. Amongst all weight loss supplements, 17.5% (95% CI: 11.07–24) contained significant concentrations of either sibutramine, phenolphthalein, or fluoxetine. Whilst weight loss herbal supplements offered for sale in the UAE have relatively low percentages of undeclared pharmaceuticals, many people take several different supplements daily and may encounter quite high levels of combined exposure to toxic compounds.
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Vasantrao, Rathod Arti. "Pharmaceutical Assessment of Body Lotion: A Herbal Formulation and its Potential Benefits." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 05 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem34273.
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Background: Protective layers of skin cover the body. Plant-based herbal body lotion soothes and moisturises. Treatments commonly include succulent aloe vera, which heals, reduces pain, and moisturises. For hundreds of years, it has healed skin burns and injuries. Aim: This study aims on the pharmaceutical assessment of Aloe-vera by formulating an herbal Body lotion. Material and Method: Aloe-vera, Honey, Glycerin, Rose Water and Triethanolamine were taken for the formulation of herbal body lotion. Evaluation parameters were also performed to evaluate the formulation and to make sure that the subjected formulation is not harmful for the human mankind. Result: The aloe vera body lotion was formulated by using various type of ingredients such as Aloe- vera, glycerin, rose water, honey and Triethanolamine. Aloe-vera contain antimicrobial and hydrating properties protect skin against microbial degradation and moisture to skin. Conclusion: herbal body lotion is prepared for tropical administration. Aloe vera is used in lotion to provide synergistic effect as well as moisturizing effect on skin. Herbal remedies are experiencing a surge in popularity worldwide. The utilization of aloe vera, honey, Coconut oil, Lemon Oil and glycerin in the formulation of an herbal lotion is an exemplary notion. Keywords: Herbal body lotion, aloe-vera, honey, skin, glycerin, pharmaceutical assessment etc.
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Rashid, Md Abdur. "Current Herbal News Vol. 25(2)." Bangladesh Pharmaceutical Journal 25, no. 2 (2022): 236. http://dx.doi.org/10.3329/bpj.v25i2.61129.
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Rashid, Md Abdur. "Current Herbal News Vol. 25(2)." Bangladesh Pharmaceutical Journal 25, no. 2 (2022): 236. http://dx.doi.org/10.3329/bpj.v25i2.61129.
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Rashid, Md Abdur. "Herbal Medicine News Vol.26(1)." Bangladesh Pharmaceutical Journal 26, no. 1 (2023): 121–23. http://dx.doi.org/10.3329/bpj.v26i1.64235.
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Sachan, Anupam Kumar, Garima Vishnoi, and Roopak Kumar. "Need of standardization of herbal medicines in Modern era." International Journal of Phytomedicine 8, no. 3 (2016): 300. http://dx.doi.org/10.5138/09750185.1847.
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<p>The medicinal plants are important source for pharmaceutical manufacturing. Medicinal plants &amp; herbal medicines account for a significant percentage of the pharmaceutical market. As the side effects of Synthetic medicine have started getting more apparent, majority of formulation are prepared from herbs. The herbal medicines however, suffer from lack of standardization parameters. The main limitation is the lack of standardization of raw materials, of processing methods and of the final products, dosage formulation, and the non existence of criteria for quality control. It is necessary to introduce measures on the regulation of herbal medicines to ensure quality, safety, efficacy of herbal medicines by using modern techniques, applying suitable standards &amp; GMP.</p>
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Padmaja, Deepa, and Nagappan Kannappan. "Standardization of traditionally designed neutraceutical." International Current Pharmaceutical Journal 1, no. 9 (2012): 288–93. http://dx.doi.org/10.3329/icpj.v1i9.11621.
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Plants are the rich source of a variety of chemicals with nutritive and therapeutic properties. The pharmacological activities of allopathic drugs are now decreased before the herbal potency. Now most of the pharmaceutical companies are focusing in this area. The Indian pharmaceutical industry is definitely looking forward to a tremendous herbal marketing. The traditionally designed neutraceutical is an Ayurvedic herbal formulation; consist of Brahmi, Tulsi, and other ingredients in powder form. This neutraceutical is proved for its antibacterial and antioxidant activity. Standardization of the traditionally designed neutraceutical is compared with the marketed product. The uses of medicinal plants are increased in developing nations. Nations like India, is a rich source of Ayurvedic plants. Government of India is also promoting the member states to formulate national policies on traditional medicine. Quality assurance is an integral part of traditional medicine. A comprehensive specification must be developed for each herbal drug preparation based on recent scientific data.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11621 International Current Pharmaceutical Journal 2012, 1(9): 288-293
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Bhusnure, Omprakash G., Madhuri C. Shinde, Swamy S. M. Vijayendra, Sachin B. Gholve, Padmaja S. Giram, and Mahesh J. Birajdar. "Phytopharmaceuticals: An emerging platform for innovation and development of new drugs from botanicals." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1046–57. http://dx.doi.org/10.22270/jddt.v9i3-s.2940.
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A phytomedicine, or phytopharmacutical, is a complex mixture derived from plant sources that is used as a medicine or drug. The Ministry of Health has begun the standardization of the names of all phytopharmaceutical preparations. The development of phytopharmaceutical products, which might partially substitute some of the conventional medications demanding imported raw materials, and which could be produced by pharmaceutical industries based in developing countries through joint projects. Highest demands are made on clinically proven phyto-pharmaceuticals. Their effect and safety have to be verified in randomized, double-blind, (placebo)-controlled clinical trials. They are developed and scientifically evaluated in the same way as conventional medicinal products. Globally, herbal medicine has been considered an important alternative to modern allopathic medicine. While they have become very popular, only select herbs have been scientifically evaluated for their potential in medical treatment. The new drug Veregen (Polyphenon E) Ointment is the first prescription botanical (herbal) drug approved by the U.S. FDA under the “new” drug amendments of 1962 that required drugs to be proven safe and effective prior to being marketed in the U.S. Because of the unique health benefits and relatively low side effects, natural products such as food/dietary supplements, nutraceuticals and herbal medicines have been gaining popularity all over the world The gap between the popularity of these remedies and the frequently weak scientific basis of their use is striking. In reality, the efficacy and true frequency of side effects for most herbal medicine products is not known because the majority have not yet been tested in large clinical trials and because pharmacovigilance systems are much less extensive than those in place for pharmaceutical products. In contrast to the popularity of herbal medicinal products, physicians and consumers often have a very critical view of robust efficacy and safety profiles. Application of pharmaceutical nanotechnology for plant actives and extracts, is gaining a tremendous growth and interest among the scientist. Keywords: Phytopharmaceuticals, Harbal, plant extract, phototherapy, Morphine, Ayurveda, metabolites, fingerprint.
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Dighe, NS, SA Nirmal, DS Musmade, and VV Dhasade. "Herbal database management." Systematic Reviews in Pharmacy 1, no. 2 (2010): 152. http://dx.doi.org/10.4103/0975-8453.75067.
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Hamood, Hebah Majed, Mohanad Abdulsahib Zaboon Alsaedi, Ayah F. Al-Qrimli, and Ali Q. Jawad. "Parkinson Disease Pharmacological and Herbal Management: A Review." South Asian Research Journal of Applied Medical Sciences 6, no. 01 (2024): 1–9. http://dx.doi.org/10.36346/sarjams.2024.v06i01.001.
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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the brain. While conventional pharmacological interventions remain the primary approach to managing PD symptoms, there is a growing interest in exploring complementary strategies, including herbal remedies. This article delves into the current understanding of both pharmacological and herbal management of Parkinson's disease. The pharmacological and herbal management of Parkinson's disease (PD) presents a comprehensive exploration of treatment strategies. While pharmaceutical interventions like levodopa are widely employed, there's growing interest in the potential contributions of herbal remedies. The current review has focused on herbs such as Mucuna pruriens, Ginkgo biloba, and Ashwagandha, investigating their neuroprotective and antioxidant properties. However, the efficacy and safety of herbal approaches in managing PD require thorough examination and validation. Collaborative efforts between pharmaceutical and herbal approaches may hold promise in optimizing PD management, but individualized care under the guidance of healthcare professionals remains paramount.
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Mosihuzzaman, Mohammed. "Herbal Medicine in Healthcare-An Overview." Natural Product Communications 7, no. 6 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700628.
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It is generally accepted by all concerned that modern pharmaceuticals will remain out of reach of many people and ‘health for all’ may only be realized by the use of adequately assessed herbal products. Mankind has been using herbal medicine for healing right from the beginning of human civilization. With the advent of ‘modern medicine’ herbal products have been looked down upon, especially by western societies. Yet, in recent times, use of herbal medicine for heathcare has increased steadily all over the world. However, serious concerns are being realized regarding the safety, claimed efficacy and quality of herbal products used as herbal medicine, nutraceuticals, health food and cosmetics. Although herbal products are generally considered safe due to their age-old usage, significant side effects have been reported for many herbal products, including herbal medicine. Accidental contamination and intentional adulteration are considered as primary reasons for the side effects. The historical perspective and the philosophy of herbal medical practice along with its present status in the light of present day science have been reviewed and included in the present article. Assurance of safety by identification of contaminants and assessment of toxicity has been outlined. Assessment of claimed efficacy of herbal medicine is difficult due to its holistic approach. Practical ways of assessing efficacy of herbal medicine by adapting the methodologies used for modern pharmaceutical are described. The maintenance of standard of herbal medicine has been stressed and pragmatic approaches of assuring quality of herbal medicine by using modern tools of fingerprinting the chemical profile of herbal medicine are discussed. As much of the traditional herbal medical knowledge is scattered around the world at the family and community levels, and more so in the indigeneous people, the knowledge base is continuously being lost and so needs immediate documentation. Difficulties in documentation due to concerns of Intellectual Property Rights (IPR) have been highlighted.
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Sharma, Parul, and R. K. Ravikumar. "Herbal pharmaceutical patent protection: Illustrative evidence on prosecution stages and section 3 [d] implication of Indian Patent Act." AYU (An International Quarterly Journal of Research in Ayurveda) 45, no. 1 (2024): 56–62. http://dx.doi.org/10.4103/ayu.ayu_71_23.
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Abstract Background: Pharmaceutical industries are increasingly vigilant on filing patent protection in the field of herbal medicine due to increase in annual growth rate/demand of natural products. These industries dependant on medicinal system(s) primarily on AYUSH system of Medicine apart from traditional knowledge practices. Since 2005, India had complied with Trade Related Aspects of Intellectual Property Rights [TRIPS] obligations by evolving suitable patent protection system. Indian patent system had advanced by various amendment(s) including Section 3 (d) of the Act (Patent Act 1970). Aim: The study is aimed essential to provide evidence in protection of desirable patent and to understand implications of Section 3 (d) in terms of protecting creativity, appreciating variations in development of pharmaceutical products. Material and methods: The study had examined 41 herbal pharmaceutical patent grants from grassroots innovations during 2021 to 2022 incubated by National Innovation Foundation-India. The implications of pharmaceutical grants with respect to Section 3 (d) were elaborated. Results: It was encouraging to note that 24 percent of these applications were accorded with herbal pharmaceutical product patent grants. The study observed that on an average these applications received grant by seven years with a prosecution period of 19 months. Conclusion: These features reflect evolving nature of IP regime in dealing with herbal pharmaceutical patent applications as India is recognized as an innovation economy. The contribution of green grassroots innovation in public health care is illustrated.
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Soni, Mahamadkhalil Sakilahemad. "Pharmaceutical Standardization of Nirgundi Guggulu." International Journal of Ayurveda and Herbal Research (IJAHR) 2, no. 1 (2024): 53–59. http://dx.doi.org/10.54060/ijahr.2024.28.
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Ayurvedic medicines have witnessed a surge in global popularity for treating various ailments. The global focus is on the phytochemical and pharmacological analysis of herbal products. Guggulu (Commiphora wightii), a commonly used herbal drug, is renowned for its anti-inflammatory, anti-hyperlipidemic, and cardio-protective properties. Among various Guggulu formulations, Nirgundi Guggulu, a notable formulation described in "Rasendra Sara Sangraha" Vata Roga chapter, is indicated for treating Vata Roga, Sannipataj Roga, and Mandal Kustha. Its ingredients, Shuddha Guggulu (Commiphora wightii) and Nirgundi root (Vitex negundo), undergo pharmaceutical procedures such as Shodhana and Vati preparations, aligning with the methods mentioned in Rasendra Sara Sangaha. However, no research has been conducted to standardize the preparation method of Nirgundi Guggulu as per classical Ayurvedic literature guidelines. The present study aims to address this by standardizing the Nirgundi Guggulu preparation process in line with classical Ayurvedic texts, ensuring consistency and quality for treatment purposes.
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Luzhanin, V. G., V. A. Kurkin, and I. V. Gravel. "Quality of Herbal Medicines: New Aspects and Solutions." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. Regulatory Research and Medicine Evaluation 13, no. 2 (2023): 128–33. http://dx.doi.org/10.30895/1991-2919-2023-13-2-128-133.
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Herbal drugs and herbal medicinal products remain of interest to Russian researchers both in terms of the development, efficacy, and safety of medicines, and in terms of the research methodology applicable to these medicine, as well as the use of new analytical methods expanding the boundaries of contemporary science and medicine. In this interview, Vladimir G. Luzhanin (Candidate of Sciences, Associate Professor, Rector of the Perm State Pharmaceutical Academy), Vladimir A. Kurkin (Doctor of Pharmaceutical Sciences, Full Professor, Chairman of the Department of Pharmacognosy with Botany and the Basics of Phytotherapy, Samara State Medical University), and Irina V. Gravel (Doctor of Pharmaceutical Sciences, Full Professor, Professor of the I.M. Sechenov First Moscow State Medical University) share their views on the application potential and future quality assessment of herbal medicines.
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Rathod, Rucha, and Raman R. Chandak. "Review on “Standardization an Imp Tool for Herbal Drug Development”." Journal of Drug Delivery and Therapeutics 9, no. 6-s (2019): 253–57. http://dx.doi.org/10.22270/jddt.v9i6-s.3784.
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The medicinal plants are important source for pharmaceutical manufacturing. Medicinal plants & herbal medicines account for a significant percentage of the pharmaceutical market. There is increasing awareness and general acceptability of the use of herbal drugs in today’s medical practice although most of these applications are not scientific. Herbal medicines are not a simple task since many factors influence the biological efficacy and Reproducible therapeutic effect. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters & by following the WHO guidelines for herbal medicines. This review seeks to enlighten the need to establish quality parameters for collection, handling, processing and production of herbal medicine as well as employ such parameters in ensuring the safety of the global herbal market. It is necessary to introduce measures on the regulation of herbal medicines to ensure quality, safety, efficacy of herbal medicines by using modern suitable standards & GMP. The processes of good quality assurance and standardization of herbal medicines and products using various spectroscopic, chromatographic and electrophoretic methods were also discussed. In fact, the research field of quality control of herbal medicines is really an interdisciplinary research. It needs crossover of chemistry, pharmacology, medicine and even statistics to provide a platform for the quality control of traditional herbal medicines and further to discover the novel therapeutics composed of multiple chemical compounds.
 Keywords: Herbal drugs, Adulteration, Standardization, Chromatography, Electrophoresis, HP-LC and GC-MS.
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Schiopu, T. A., M. D. Brumarel, A. I. Peschin та S. B. Adauji. "Рarticipation of pharmacists in managing the use of herbal medicines by the elderly". Social Pharmacy in Health Care 8, № 4 (2022): 23–30. http://dx.doi.org/10.24959/sphhcj.22.270.
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Recent data indicate that the pharmaceutical market for herbal medicines continues to grow steadily, and this enables pharmacists to improve their professional skills in managing the treatment of the elderly with herbal medicines and identify potential problems associated with their use. 
 Aim. To study the practice of using herbal medicines among elderly patients from the pharmacist’s point of view and identify specific recommendations of pharmacists in managing the use of herbal medicines. 
 Materials and methods. A descriptive design study was conducted; the main research tool was a questionnaire for pharmacists. 
 Results. Pharmacists’ responses indicate that the use of herbal medicines in the elderly is common, herbal preparations are used mainly for treating chronic diseases, and in most cases elderly patients associate the quality of treatment with the co-use of traditional medicines with herbal ones; often older patients also have false information about the requested herbal medicines. This means the need for pharmacists to monitor and supervise the use of herbal medicines by the elderly, special attention should be paid to the results of drug-herbal interactions and to regular updating of knowledge in the field of geriatric pharmaceutical care oriented to herbal therapy.
 Conclusions. Based on the results of the study, the problems associated with the use of herbal medicines in the elderly have been described, and some specific recommendations for pharmacists related to the treatment with herbal medicines in the elderly have been proposed.
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Komal N. Pawar, Komal N. Pawar, Sandhya P. Kadam Sandhya P. Kadam, and Dr VivekkumarK Redasani Dr.VivekkumarK.Redasani. "A Systematic Review on High Performance Thin Layer Chromatography (HPTLC)." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 402–16. https://doi.org/10.35629/4494-1003402416.
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High-Performance Thin Layer Chromatography (HPTLC) is a sophisticated analytical tool that has transformed the science of separation science through its greater sensitivity, resolution, and reproducibility over the conventional Thin Layer Chromatography (TLC). This systematic review delves into the concept, instrumentation, methodological innovation, and vast applications of HPTLC in pharmaceuticals, herbal drugs, food, forensic science, and biotechnology. The review highlights the most important innovations in automation, detection, derivatization, and hyphenation with mass spectrometry and FTIR that have greatly widened the application potential of HPTLC. The review highlights validated methods for quantifying drugs like Piperine in herbal cough syrup and Ondansetron Hydrochloride in tablet formulations, demonstrating the technique‘s robustness and accuracy in routine pharmaceutical quality control.