To see the other types of publications on this topic, follow the link: Herbal contraceptives.
Journal articles on the topic 'Herbal contraceptives'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Herbal contraceptives.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Baghel Chauhan, Shikha, and Tanveer Naved. "HERBAL CONTRACEPTIVES: EVALUATION OF ANTIFERTILITY POTENTIAL OF HIBISCUS ROSA‑SINENSIS (LINN.)." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (November 7, 2018): 36. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.20531.
Full textAbstract:
This review explores, evaluates, and analyzes the contraceptive potential of Hibiscus rosa-sinensis L. There are large numbers of synthetic contraceptives available in the market. These synthetic contraceptives are associated with many side effects ranging from user discomfort to toxicity. India is a land of traditional herbal medicines. People are finding and exploring the advantages associated with herbal contraceptives because of their lower side effects. Herbal contraceptives have lower cost of development as compared to modern medicine. This review explores the recent advances in development that offers many benefits for shifting the paradigm for herbal contraceptives. From times immemorial, references have been made for the plants that possess antifertility properties. This review explores the need for the development of herbal contraceptives from the plant H. rosa-sinensis L. H. rosa-sinensis L is reported to have antiovulatory activity. However, the need of the hour is to assess and carry out toxicological studies and initiate development activity for formulation development.
2
Valmiro, Daniella Jordão, Lucas Moyses Pinto, Lucas Nascimento Barbosa, Luiza Beatriz Carvalho de Araújo, and Rodrigo Vieira Gonzaga. "Drug interactions between herbal medicines and oral contraceptives." Research, Society and Development 10, no. 13 (October 16, 2021): e372101321331. http://dx.doi.org/10.33448/rsd-v10i13.21331.
Full textAbstract:
The use of herbal medicines has grown considerably in recent years, due to the erroneous thought that products of plant origin are harmless, and therefore do not cause adverse effects or have drug interactions. The use of these drugs with oral contraceptives can bring risks to patients. The potential negative clinical effects that can be caused by these drug interactions must be emphasized to prevent risks and ensure the effectiveness of this contraceptive method that is one of the most used by women seeking to prevent pregnancy. The users of herbal medicines usually believe that herbal medicine is a therapeutic alternative free of adverse effects and/or incapable of causing drug interactions, but herbal medicines are composed of several chemical compounds, which, in turn, may be responsible for antagonistic and/or synergistic effects with other drugs. The main interactions that can occur with contraceptives are with popularly used herbal medicines such as licorice, alfalfa, cannabis, cimicifuga, St. John's wort, ginseng, kava-kava, saw palmetto, sene, and soy. The herbal medicines have several chemical compounds, among which we highlight the secondary metabolites, responsible for the pharmacological actions and mechanism of action of drug interactions, which are often similar in plants that have in their composition the same metabolites, as in the case of saponins and isoflavones that reduce the speed of biotransformation of oral contraceptives.
3
Roy Chaudhury, Ranjit. "Folklore herbal contraceptives and remedies." Trends in Pharmacological Sciences 7 (January 1986): 121–23. http://dx.doi.org/10.1016/0165-6147(86)90282-8.
Full text
4
SHAHIDAN, WAN NAZATUL SHIMA, TUAN NADRAH NAIM TUAN ISMAIL, and KANNAN THIRUMULU PONNURAJ. "Malaysian Herbs in Contraception: Public Perception." Jurnal Sains Kesihatan Malaysia 20, no. 1 (January 1, 2022): 129–37. http://dx.doi.org/10.17576/jskm-2022-2001-12.
Full textAbstract:
Medicinal plants have been used in Malaysia for a long time ago. These plants have been marketed as herbal product and used in the traditional healthcare system because of its positive therapeutic effects. This paper discusses particularly several types of Malaysian herbs that are traditionally used for contraception and scientific studies related to its pharmaceutical properties showing its use among the public for its anti-fertility effects. Even though several methods of contraception have been promoted for family planning, yet, the perception of the public on the usage of synthetic steroidal contraceptives due to its serious adverse effects has made them focus on indigenous plants. Contraceptives drug-containing oestrogen and progesterone have proven to be effective and popular, However, the side effects of these drugs have sparked the idea of scientists to develop newer molecules from medicinal plants. Therefore, it is necessary to investigate in-depth qualitative research on conceptions and concerns about traditional contraceptive methods using herbal ingredients among Malaysians.
5
Shukla, Akshara, Rohitash Jamwal, and Kumud Bala. "ADVERSE EFFECT OF COMBINED ORAL CONTRACEPTIVE PILLS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 1 (January 1, 2016): 17. http://dx.doi.org/10.22159/ajpcr.2017.v10i1.14565.
Full textAbstract:
ABSTRACTOral contraceptive (OC) pills contain estrogen and progestin that are synthetic analogs of natural hormones. These synthetic hormones affectthe hypothalamus-pituitary-gonadal axis of the female reproductive system. There are many types of contraceptives; most of the OC pills preventpregnancy by inhibiting ovulation. Estrogen and progestin are two female reproductive hormones that are critical. Typically, estradiol is producedby growing follicle (ovaries) which stimulates the hypothalamus to produce the gonadotropin-releasing hormone, which further stimulates theanterior pituitary to produce follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH production triggers the ovulation. Similarly, theprogesterone is produced by corpus luteum (ovaries), which triggers the production of FSH and LH. There are many types of progesterone available.Long-term usage of synthetic estrogen and progesterone can disturb the balance between the level of these hormones in the body. This imbalance maylead to severe side effects such as breast cancer, cervical cancer, thrombosis, direct impact on the brain, and infertility.Keywords: Estrogen, Progesterone, Contraceptives, Herbal contraceptives.
6
Wiryawan, Reryd Arindany, Reny I'tishom, and Sri Purwaningsih. "PAPAYA SEED EXTRACT LOWERS SPERM CONCENTRATIONS, MOTILITY AND VIABILITY IN MALE MICE." Folia Medica Indonesiana 51, no. 4 (November 15, 2016): 252. http://dx.doi.org/10.20473/fmi.v51i4.2855.
Full textAbstract:
Indonesia is a developing country with a dense population, so the government carry on KB (Family Planning) program in which the targets are mostly women. Contraceptives are intended for women are birth control pills and IUD (Intra Uterine Device), whereas until now the contraceptive for men who are considered well-established are condom and vasectomy. Thus, the development of herbal medicine, which is cheap and affordable, makes it possible to be consumed in a long term with less meaningful side effects. Papaya seeds (Carica papaya) is one of the many plants used by communities to eradicate intestinal worms, menstrual laxative, and abortivum. Empirically papaya fruit, leaves, and seeds of papaya also contains carpaine, an alkaloid which is used as anthelmintic. Papaya seeds, which are edible and spicy in India are used for contraception. Alkaloid content in seeds of papaya can be antifertility herbal plants for males that can be measured from the quality of spermatozoa. Alkaloid compounds contained in papaya seeds can disrupt the hormone testosterone, which would interfere the sperm quality, making papaya seed potential to become a candidate for contraceptive.
7
Saha, Anumita, Aishi Chatterjee, Shristi Singh, Jaya Ghosh, Mrityunjoy Majumdar, Sourav Roy, and Prodip Roy. "Herbal Agents Having Abortive Activity." Journal for Research in Applied Sciences and Biotechnology 1, no. 3 (August 31, 2022): 204–15. http://dx.doi.org/10.55544/jrasb.1.3.27.
Full textAbstract:
The goal of our study is to increase public awareness of natural contraceptives and their powerful advantages over surgical abortion in order to provide people with an alternative method of ending an unwanted or unplanned pregnancy rather than the dreaded surgical procedure. Since ancient times, traditional remedies have been used all across the world to control fertility. Still, the tribal community mostly relies on these herbs for contraception and to cause abortions. The belief in therapeutic approaches has not been diminished despite the tremendous advancement of allopathic treatment because of its negative side effects. Plants and herbs have been used to induce abortions, although there is very little published information on the most regularly used ones. The grail of this paper is to detail the herbal products used to cause abortion.
8
Dhingra, Ashwani K., and Bhawna Chopra. "Herbal Remedies for Birth Control: An Alternative to Synthetic Hormonal Contraceptives." Current Women s Health Reviews 16, no. 4 (September 9, 2020): 290–97. http://dx.doi.org/10.2174/1573404816999200511002829.
Full textAbstract:
Background: Both women and men wish to have control over when to become parents. Birth control or contraception methods basically entail different types of mechanisms to avoid pregnancy. Making choices about birth control methods is not easy since there are many types of fertility control techniques available to avoid pregnancy. Objective: Several health problems are associated with females or males on the prominent use of oral contraceptives/pills. To reduce the side effects of these pills, nature provides us with several medicinal plants that act as good birth control pills. So this review aims to focus on the database provided in the literature to use these medicinal plants to avoid or control the severe health problems which directly or indirectly affect the health of the individual. Methods: All significant databases were collected via electronic search using PubMed, Scopus, Web of Science and Science direct and were compiled. Results: Several common options include family planning through abstinence, hormonal methods like oral contraceptives, barrier methods, etc. Apart from this, some people who do not want to have children may opt for permanent sterilization, but these methods or pills, when taken orally, change the hormonal balance of the individual, which leads to the other disorders. Thus, this present review concludes the knowledgeable erudition on the natural plants acting as antifertility agents. Conclusion: This review article is mainly focused on the natural birth control methods to combat pregnancy and also emphasize on various medicinal active plants being used to avoid fertility.
9
Adebisi, Mobolawa. "An ethnobotanical survey of herbal male contraceptives used in south- west Nigeria." African Journal of Pharmacy and Pharmacology 5, no. 2 (February 28, 2011): 289–91. http://dx.doi.org/10.5897/ajpp09.316.
Full text
10
Shader, Richard I., and David J. Greenblatt. "More on Oral Contraceptives, Drug Interactions, Herbal Medicines, and Hormone Replacement Therapy." Journal of Clinical Psychopharmacology 20, no. 4 (August 2000): 397–98. http://dx.doi.org/10.1097/00004714-200008000-00001.
Full text
11
Mali, P. "O573 Are herbal male contraceptives a better option to control human population." International Journal of Gynecology & Obstetrics 107 (October 2009): S256. http://dx.doi.org/10.1016/s0020-7292(09)60946-2.
Full text
12
Barnes, Joanne. "Charms & Harms: St John's Wort (Hypericum perforatum)." Journal of Primary Health Care 1, no. 1 (2009): 65. http://dx.doi.org/10.1071/hc09065.
Full textAbstract:
SUMMARY MESSAGE: St Johns wort is about as effective as some conventional antidepressants (NNT=42) including certain SSRIs for treating mild to moderate depression and has a favourable adverse effect profile, at least with short-term use. However, it interacts with several other medicines, including digoxin, theophylline, warfarin and oral contraceptives. As with all herbal medicines, different St Johns wort products differ in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.
13
C, Karthika, Manivannan S, and Jawahar S. "Qualitative and quantitative screening of phytoconstituents and characterization of various extracts of Wedelia trilobata leaf extracts." International Journal of Ayurvedic Medicine 13, no. 2 (July 8, 2022): 429–35. http://dx.doi.org/10.47552/ijam.v13i2.2365.
Full textAbstract:
The birth control pills (contraceptive) are safe, in some cases the combination of the contraceptive pill can increase your risk of health. The side effects include heart attack, stroke, blood clots, and liver tumors. In very rare cases, they can lead to death. The risk of health problems and side effects were minimal or no side effects recorded while using the herbal contraceptives. The present investigation was focused on the preliminary phytochemical analysis, UV-VIS spectrum and Fourier Transform Infrared Spectral analysis and HPLC analysis of Wedelia trilobata L. The leaves were extracted using soxhlet extractor with seven different solvent in the order of relative polarity (aqueous, methanol, ethanol, acetone, petroleum ether, benzene and hexane) the leaves of the plant of Wedelia trilobata L. were tested for the availability of alkaloids, glycosides, flavonoids, phenols, saponins, steroids, amino acids, tannins, terpenoids, quinones, anthraquinones etc. And the phenol, flavonoid and terpenoids were analysed quantitatively. The UV-VIS spectrum showed the peaks with the absorption for the seven solvents respectively. The FT-IR spectrum showed the presence of alcohols, phenols, alkanes, alkynes, alkyl halides, aldehydes, aromatics, nitro compounds and amines. With the HPLC results we confirm that the compound caryophyllene which was used as contraceptive now a days was present in the two extracts (aqueous and ethanol) The results confirm the fact that this plant possesses important bioactive constituents useful for our health, so further scientific investigation is needed to investigate the biological activities of this plant.
14
Tuccori, M., S. E. Giustini, B. Federighi, S. Montagnani, L. Antonioli, M. Fornai, C. Blandizzi, and M. Del Tacca. "Thrombotic Thrombocytopenic Purpura Resulting from Interaction between Oral Contraceptives and Herbal Supplements Containing Phytoestrogens." Drug Safety 29, no. 10 (2006): 911–1010. http://dx.doi.org/10.2165/00002018-200629100-00181.
Full text
15
Artymuk, N. V., and O. A. Tachkova. "New about the pathogenesis and treatment of polycystic ovary syndrome." Russian Journal of Woman and Child Health 4, no. 1 (2021): 17–22. http://dx.doi.org/10.32364/2618-8430-2021-4-1-17-22.
Full textAbstract:
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age that is characterized by reproductive and metabolic disorders. Mental issues, hypothalamic-pituitary dysfunction, ovarian dysfunction, mitochondrial dysfunction, obesity, and vitamin D deficiency account for infertility in PCOS. This paper reviews recent studies on pathogenesis and treatment approaches to this disease. Recognized therapeutic modalities for PCOS are addressed, i.e., rational diet, combined hormonal contraceptives, ovulation induction using clomiphene citrate and/or metformin, ovarian drilling, assisted reproductive technology, and alternative approaches (e.g., herbal therapy, traditional Chinese medicine, vitamin D, coenzyme Q, salubrinal, and the combination of simvastatin and metformin). Inositols are a promising therapeutic modality that improves menstrual and reproductive function (presumably via their impact on carbonic and lipid metabolism) and the quality of oocytes and embryos. KEYWORDS: polycystic ovary syndrome, pathogenesis, treatment, myo-inositol, ovulation induction, drilling, combined oral contraceptives, lifestyle changes. FOR CITATION: Artymuk N.V., Tachkova O.A. New about the pathogenesis and treatment of polycystic ovary syndrome. Russian Journal of Woman and Child Health. 2021;4(1):17–22. DOI: 10.32364/2618-8430-2021-4-1-17-22.
16
Goswami, Priyanka, Moksood Ahmed Laskar, and Mrinmoy Basak. "A Review on Medicinal Plants of North Eastern Region with Potential Antifertility Activity." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (June 15, 2020): 162–65. http://dx.doi.org/10.22270/ajprd.v8i3.762.
Full textAbstract:
The increase in population is becoming a comprehensive problem, causing much pressure on economic, social and natural assets. Oral contraceptive agents have improved the rate of infertility but their unusual side effects limit the use. Current antifertility therapy lacks satisfactory success due to this adverse effect; hence, patients are seeking complementary and alternative medicine for anti-fertility action. Ayurveda and other Indian literature mention the use of plants in various human ailments. India has about more than 45000 plant species and among them several thousand are claimed to possess medicinal properties. Researchers conducted in the last few decades on the plants mentioned in ancient literature or used traditionally for anti-fertility action. This review reveals that some plants and their part used having anti-fertility action, which are helpful for researcher to develop new herbal anti-fertility formulations. In the recent years, interest in drugs of plant origin has been progressively increased. The aim of this review is to highlight the work on anti-fertility of plant origin. For women who can't use modern forms of contraception due to adverse effect or other reasons, therefore herbs can offer alternatives and reducing fertility would be better than other contraceptives. This article may help investigators to identify medicinal plants responsible for anti-fertility activity.
17
Singh, Sadhna, Neha Priya, Debabrata Roy, Anurag Srivastava, and Surekha Kishore. "Trends in contraceptive demands and unmet need for family planning in migrant population of Uttarakhand." International Journal Of Community Medicine And Public Health 5, no. 2 (January 24, 2018): 590. http://dx.doi.org/10.18203/2394-6040.ijcmph20180234.
Full textAbstract:
Background: The knowledge of contraceptive use and unmet need is important to know the constraints for unmet need based on user perspective. The aim of the study was to find the prevalence of Contraceptive use, Contraceptive preferred and the Un-met demand for contraceptives. Methods: Married, non-pregnant women of reproductive age group (15-49 years) from the migrant population were interviewed by Census method using pre-designed and pre-tested instrument by cross-sectional survey. Operational definitions for unmet need for spacing, limiting and unfelt need used in the study were as per NFHS -4 findings and traditional methods of contraception like abstinence, withdrawal were included in Un-met need for contraceptive due to its very high failure rate. Results: 58.44% study subjects had ‘Ever Used FP’ and 56.78% are currently using FP methods. The CPR is 56.7% by ‘Any Method’ and 43.0% by ‘Modern method’. The method which is most popular is ‘Sterlisation 29% and 20.96% and ‘Others’ i.e. highly unreliable methods like coitus interruptus, calendar method etc. found high number of users. The reasons for non use were apprehension of complication/side effects in 39%) and inconvenience or the difficulties with modern contraceptive methods or lack of knowledge by 7.67% and 6.95% respectively, 16% were relied on traditional methods, such as periodic abstinence, withdrawal and herbal mixtures from traditional healers as well as LAM 8% for a FP method, all of which have high failure rate. Only 24.8% Women were decision maker regarding the time and type of contraceptive to be used. The unmet need was 29.7% out of which the unmet needs for spacing and limiting were 9.6 per cent and 20.1 per cent, respectivelyConclusions: The unmet need is high and can be addressed by removing the constraints such as poor accessibility to the knowledge thus removing apprehension for side effects, improve accessibility to resources and low decision-making autonomy.
18
Oktanella, Yudit, Husayn Satria Nugroho, Desi Wulansari, Viski Fitri Hendrawan, Galuh Chandra Agustina, and Agri Kaltaria Anisa. "Infertility Impact of Cotton Seeds (Ceiba pentandra) and Eggplant Cepoka (Solanum torvum) on the Nfkb Expression and Seminiferous Tubules Diameter." Journal of Experimental Biology and Agricultural Sciences 10, no. 5 (October 31, 2022): 1109–14. http://dx.doi.org/10.18006/2022.10(5).1109.1114.
Full textAbstract:
The presence of the solasodine and gossypol compounds in Kapok seeds (Ceiba pentandra) and cepoka eggplant (Solanum torvum) suggest the use of these two as an herbal contraceptive ingredient in male animal fertility. This study aimed to determine the effect of cepoka eggplant extract (S. torvum) and kapok seed (C. pentandra) on infertility in rats (Rattus norvegicus) through NFkB expression and seminiferous tubule diameter. The study was carried out on 75 to 90 days old male Wistar rats having 150-200 grams of body weight. The experimental design used in this study was a completely randomized design (CRD) with three treatment groups i.e. C (control), KP1, and KP2 having six rats in each group. Here the rats of group C were not treated with gossypol or solasodine while the rats of group KP1 were treated with solasodine compound at a dose of 1g/kg BW and rats of group KP2 were treated with gossypol induction at a dose of 0.1 g/kg BW. Kapok seed extract and eggplant cepoka extract were extracted by the maceration method with 70% ethanol solvent. NFkB expression was examined using the immunohistochemical (IHK) method, which was analyzed with immunoratio software. Histopathological preparations (HE) of seminiferous tubule diameter were analyzed using raster image software 3. All the obtained data were analyzed by the One Way ANOVA test and Tukey's follow-up test with a 95% confidence level (α = 0.05). The results showed that the administration of cepoka eggplant extract could significantly increase the expression of NFkB (p<0.05) with an average amount of 87.22 ± 6.89 with a dose of 1 g/kg BW. Treatment with Kapok seed extract can reduce the diameter of the seminiferous tubules (STs) by an average of 0.31 ± 0.016 at a dose of 0.1 g/kg BW. The results of the study can be concluded that the extract of cepoka eggplant and kapok seeds can be used as candidates for herbal contraceptives.
19
Odette N Kabena, Jean Jacques D Amogu, Nadège K Ngombe, EJ Mboloko, Pius T Mpiana, and Félicien L. Lukoki. "Feminine intimate hygiene plants from Kinshasa / DR Congo: Potential source of contraceptive compounds." International Journal of Life Science Research Archive 1, no. 1 (September 30, 2021): 071–78. http://dx.doi.org/10.53771/ijlsra.2021.1.1.0055.
Full textAbstract:
This study is part of the promotion of local medicinal plants by highlighting their spermicidal activity. An ethnobotanical survey carried out in Kinshasa made it possible to identify the plants used in female intimate hygiene. On the one hand, the aqueous extracts of the organs of ten (10) plants on the inventoried species were subjected to a phytochemical analysis. On the other hand, the recipes as applied by women as well as the total extracts of these plants have come into contact with human sperm. The analysis of the mobility and the evaluation of the viability of the sperm of the ejaculates, of good quality according to the WHO, were carried out according to the methods of Sander-Cramer and that of Williams, respectively. Thus, the concentration (EC100) capable of killing 100% of sperm within 30 minutes of exposure was detected. Thirty-eight (38) plant species have been identified. From thirteen sought-after phytochemical groups, extracts of Mangifera indica and Bridelia ferruginea contain twelve and eleven respectively. Four (4) groups of metabolic compounds with a contraceptive effect are present in all ten extracts of feminine hygiene plants. Three (3) herbal recipes (Abrus precatorius, Bridelia ferruginea and Ocimum basilicum) out of the ten studied resulted in the cancellation of sperm mobility after 3 hours of exposure. And, the EC100 is defined at 200 mg/mL for A. precatorius and 25 mg / mL for B. ferruginea. The results of this study show that feminine intimate hygiene plants contain compounds with spermicidal potential, which can be used for the development of vaginal contraceptives.
20
Liao, Wan-Ting, Jen-Huai Chiang, Chia-Jung Li, Ming-Tsung Lee, Cheng-Chiung Su, and Hung-Rong Yen. "Investigation on the Use of Traditional Chinese Medicine for Polycystic Ovary Syndrome in a Nationwide Prescription Database in Taiwan." Journal of Clinical Medicine 7, no. 7 (July 22, 2018): 179. http://dx.doi.org/10.3390/jcm7070179.
Full textAbstract:
Polycystic ovary syndrome (PCOS) is a common condition, affecting 5–10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all its symptoms. Existing pharmaceutical agents, such as oral contraceptives (OCs), are suggested as a first-line therapy for menstrual irregularities; however, OCs are not appropriate for women pursuing pregnancy. Additionally, insulin-sensitizing agents, which appear to decrease insulin levels and hyperandrogenemia in women with PCOS, have been associated with a high incidence of gastrointestinal adverse effects. It is a common practice in Chinese society to receive traditional Chinese medicine (TCM) for treatment of gynecological problems and infertility. Current research demonstrates that several herbs and herbal formulas show beneficial effects in PCOS treatment. In this study, we conducted the first large-scale survey through the Taiwan National Health Insurance Program database to analyze TCM utilization patterns among women with PCOS in Taiwan during 1997–2010. The survey results revealed that 89.22% women with newly diagnosed PCOS had received TCM therapy. Jia-Wei-Xiao-Yao-San and Xiang-Fu (Rhizoma Cyperi) were the most commonly used formula and single herb, respectively, in the database. In addition, we found that the top five commonly prescribed single herbs and herbal formulas have shown promise in treating symptoms associated with PCOS.
21
Pakhira, Bhabani Prasad, Abhinandan Ghosh, Adrija Tripathy, and Debidas Ghosh. "Antitesticular activities of different solvent fractions from hydro-methanol (2:3) extract of Cuminum cyminum in albino rat: A Comparative analysis." International Journal of Phytomedicine 9, no. 4 (December 28, 2017): 605. http://dx.doi.org/10.5138/09750185.2131.
Full textAbstract:
Currently available contraceptives are associated with adverse effects. So, search on safer agents in this purpose is one of the priority areas of WHO. Our previous study showed a significant antifertility effect of hydro-methanol extract of <em>Cuminum cyminum</em> Linn (Umbelliferae) in male albino rat. The main objective of this work isto search outthe potentfraction of hydro-methanol extract of seed of <em>Cuminum cyminum</em> in adult male albino rat for the development of herbal male contraceptive to reduce the bio-burden of phytomolecules. The n-hexane, chloroform, ethyl acetate, and n-butanol fractions of the hydro-methanol (2:3) extract of seed of <em>Cuminum cyminum</em> were administrated orally to male rat. Results showed the maximum antitesticular activity of chloroform fraction (CH-Fr) than other fractions included here. Treatment with CH-Fr fraction resulted a significant inhibition in spermiological parameters, activities of testicular androgenic key enzymes and antioxidative enzymes, levels of serum testosterone and seminal vesicular fructose, number of different generations of germ cells at stage VII of spermatogenic cell cycle and seminiferous tubular diameter (STD) along with significant increase in the level of testicular cholesterol in respect to the control. Significant upward and downward expression in Bax and Bcl-2 gene of male germ cells were indicated which focussed the sperm apoptotic enhancer activities of the fraction. The findings indicated that among the said four different fractions, the chloroform fraction of the hydro-methanol extract of the seed of <em>Cuminum cyminum</em> had most effective antitesticular activity.
22
Afriani, Anita Indra, Nor Khayati, and Julvainda Eka Priya Utama. "Pengaruh Serbuk Kunyit (Curcuma Domestica Valet) Terhadap Kecepatan Reversibilitas Kesuburan Wanita Pasca Menggunakan KB Suntik DMPA." Jurnal SMART Kebidanan 8, no. 1 (June 30, 2021): 13. http://dx.doi.org/10.34310/sjkb.v8i1.450.
Full textAbstract:
KB Suntik DMPA (Depo Medroksi Progesterone Asetat) berisi depo medroksi progesterone asetat yang diberikan dalam suntikan tunggal 150mg/ml secara intramuscular (IM) setiap 12 minggu. Keterbatasan KB suntik DMPA adalah reversibilitas kesuburan lambat. Tindakan untuk mengemblikan reversibilitas ini dilakukan dengan memberikan obat kimia dan herbal, salah satunya kunyit, sebab kunyit memiliki efek untuk melancarkan darah dan menambah energi, anti inflamasi, mempermudah persalinan, anti bakteri, memperlancar pengeluaran empedu, pelembab serta mengembalikan kesuburan wanita.. Tujuan penelitian ini untuk mengetahui pengaruh serbuk kunyit (Curcuma domestica Valet) terhadap kecepatan reversibilitas kesuburan wanita pasca menggunakan KB Suntik DMPA di PMB N Desa Sidigede Welahan Jepara. Metode penelitian menggunakan kuantitatif dengan rancangan two group post-test with control group design dengan kelompok intervensi di berikan serbuk kunyit dan kelompok kontrol tidak diberikan serbuk kunyit. Jumlah sampel sebanyak 16 responden untuk intervensi dan 16 untuk kontrol dengan accidental sampling . Analisis data menggunakan Uji Mann Whitney didapatkan nilai p value 0.000 berarti ada pengaruh serbuk kunyit terhadap kecepatan reversibilitas kesuburan wanita pasca menggunakan KB suntik DMPA. Sehingga di dapatkan kesimpulan serbuk mempercepat reversibilitas kesuburan wanita pasca menggunakan KB Suntik DMPA. Kata kunci : KB suntik DMPA; reversibilitas kesuburan; serbuk kunyit The Effect of Curcuma Domestica Valet Towards The Reversibility of Women’s Fertility Post Using Injectable Contraceptives of DMPA ABSTRACT Depo Medroxy Progesterone Acetate (DMPA) Injection contraception contains Depo Medroxy Progesterone Acetate which is given in a single injection of 150mg/ml intramuscularly (IM) every 12 weeks. The limitation of DMPA injectable contraception is the slow fertility reversibility. The action to restore this reversibility is carried out by giving chemical and herbal medicines, one of which is turmeric, because turmeric has the effect of improving blood circulation and increasing energy, anti-inflammatory, facilitating childbirth, anti-bacterial, facilitating bile secretion, moisturizing and restoring female fertility. The purpose of this study was to determine the effect of turmeric powder (Curcuma domestica Valet) towards the reversibility of female fertility after using DMPA injectable contraception at N Maternal Clinic of Sidigede Welahan Village, Jepara. The research method used quantitative with two group post-test design with control group design, the intervention group was being given turmeric powder and the control group not being given turmeric powder. The numbers of samples were 16 respondents for the intervention and 16 for the control with accidental sampling. Data analysis used the Mann Whitney test obtained a p value of 0.000 which means that there is an effect of turmeric powder on the rate of reversibility of female fertility after using DMPA injection contraception. So it can be concluded that the powder accelerates the reversibility of female fertility after using DMPA injectable contraception. Key words: Injectable contraceptives DMPA; fertility reversibility; turmeric powder
23
Nnaji, A. C., and O. R. Ijomone. "Conventional and Alternative Management of Dysmenorrhea – A Narrative Review." Journal of Basic and Social Pharmacy Research 2, no. 2 (2021): 45–56. http://dx.doi.org/10.52968/27455106.
Full textAbstract:
Introduction: Dysmenorrhea also known as painful menstruation is a public health problem with high prevalence among adolescents. It is defined as a severe, painful, cramping sensation within the lower abdomen occurring just before, during or few days after menstruation starts. Dysmenorrhea can negatively affect a woman's quality of life and interfere with daily activities. The two categories of dysmenorrhea are primary and secondary. Dysmenorrhea occurring in the absence of any pathological condition of the pelvis is known as primary dysmenorrhea while dysmenorrhea occurring in the presence of pathological condition of the pelvis is called secondary dysmenorrhea. Aim of review: The purpose of this review is to present a general overview of the types, epidemiology, diagnosis and available treatment options of both primary and secondary dysmenorrhea. Methods: PubMed, Google Scholar and Medline search engines (2000 to 2021) were used to conduct searches of relevant articles on dysmenorrhea. Citation lists of publications, including studies for randomized controlled trials (RCTs) and review articles were searched. Conclusion: Although prevalence is difficult to determine, dysmenorrhea may affect as high as 90% of menstruating women. Risk factors for dysmenorrhea may include smoking, early menarche, nulliparity, and family history. Analgesics and oral contraceptives are the mainstay of treatment for primary dysmenorrhea. Complementary and alternative treatments options such as herbal medicines, exercise and diet are also available. Addressing the underlying pathology of secondary dysmenorrhea is the main stay for its management.
24
Laidlaw, Maggie, Carla A. Cockerline, and Daniel W. Sepkovic. "Effects of A Breast-Health Herbal Formula Supplement on Estrogen Metabolism in Pre- and Post-Menopausal Women not Taking Hormonal Contraceptives or Supplements: A Randomized Controlled Trial." Breast Cancer: Basic and Clinical Research 4 (January 2010): BCBCR.S6505. http://dx.doi.org/10.4137/bcbcr.s6505.
Full textAbstract:
Introduction Both indole-3-carbinol and dietary lignans have beneficial effects on estrogen metabolism and breast cancer risk. There is no published literature on the effects of a combination product. This study was designed to investigate the impact of a combination product on estrogen metabolism. The major trial objective was to determine whether a breast health supplement containing indole-3-carbinol and hydroxymatairesinol lignan would alter estrogen metabolism to favour C-2 hydroxylation and reduce C-16 hydroxylation. Higher concentrations of C-2 metabolites and lower concentrations of C-16 metabolites may reduce breast cancer risk and risk for other hormonally-related cancers. Methods Forty-seven pre-menopausal and forty-nine post-menopausal women were recruited for this study, and were divided by random allocation into treatment and placebo group. The treatment supplement contained HMR lignan, indole-3-carbinol, calcium glucarate, milk thistle, Schisandra chinesis and stinging nettle, and each woman consumed either treatment or placebo for 28 days. At day 0 and day 28, blood samples were analysed for serum enterolactone concentrations, and first morning random urine samples were assessed for estrogen metabolites. Repeated measures ANOVA statistical testing was performed. Results In pre-menopausal women, treatment supplementation resulted in a significant increase ( P < 0.05) in urinary 2-OHE concentrations and in the 2:16α-OHE ratio. In post-menopausal women, treatment supplementation resulted in a significant increase in urinary 2-OHE concentrations. In pre- and post-menopausal women combined, treatment supplementation produced a significant increase in urinary 2-OHE concentration and a trend ( P = 0.074) toward an increased 2:16α-OHE ratio. There were no significant increases in serum enterolactone concentrations in the treatment or placebo groups. Conclusions Supplementation with a mixture of indole-3-carbinol and HMR lignan in women significantly increased estrogen C-2 hydroxylation. This may constitute a mechanism for the reduction of breast cancer risk as well as risk for other estrogen-related cancers. Further studies with higher numbers of subjects are indicated. Trial Registration ClinicalTrials.gov registration #NCT01089049.
25
Hifnawy, Mohammed S., Mahmoud A. Aboseada, Hossam M. Hassan, Asmaa M. AboulMagd, Adel F. Tohamy, Samraa H. Abdel-Kawi, Mostafa E. Rateb, et al. "Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies." Metabolites 10, no. 1 (January 11, 2020): 31. http://dx.doi.org/10.3390/metabo10010031.
Full textAbstract:
Many routes have been explored to search for effective, safe, and affordable alternatives to hazardous female contraceptives. Herbal extracts and their secondary metabolites are some of the interesting research areas to address this growing issue. This study aims to investigate the effects of ten different plant extracts on testicular spermatogenesis. The correlation between the chemical profile of these extracts and their in vivo effect on male reproductive system was evaluated using various techniques. Approximately 10% of LD50 of hydro-methanolic extracts were orally administrated to rats for 60 days. Semen parameters, sexual organ weights, and serum levels of male sex hormones in addition to testes histopathology, were evaluated. Moreover, metabolomic analysis using (LC-HRESIMS), multivariate analysis (PCA), immunohistochemistry (caspase-3 and β-catenin), and a docking study were performed. Results indicated that three plant extracts significantly decreased epididymal sperm density and motility. Moreover, their effects on testicular cells were also assured by histopathological evaluations. Metabolomic profiling of the bioactive plant extracts showed the presence of diverse phytochemicals, mostly oleanane saponins, phenolic diterpenes, and lupane triterpenes. A docking study on caspase-3 enzyme showed that oleanane saponins possessed the highest binding affinity. An immunohistochemistry assay on β-catenin and caspase-3 indicated that Albizzia lebbeck was the most active extract for decreasing immunoexpression of β-catenin, while Rosmarinus officinalis showed the highest activity for increasing immunoexpression of caspase-3. The spermatogenesis decreasing the activity of A. lebbeck, Anagallis arvensis, and R. officinalis can be mediated via up-regulation of caspase-3 and down-regulation of β-catenin existing in testis cells.
26
Laidlaw, Maggie, Carla A. Cockerline, and Daniel W. Sepkovic. "Erratum for “Effects of a Breast-Health Herbal Formula Supplement on Estrogen Metabolism in Pre- and Post-Menopausal Women not Taking Hormonal Contraceptives or Supplements: A Randomized Controlled Trial”." Breast Cancer: Basic and Clinical Research 6 (January 2012): BCBCR.S10022. http://dx.doi.org/10.4137/bcbcr.s10022.
Full text
27
Vikram, Baburao, Neetu Rawal, and Sunil Gupta. "An open-label pilot study to evaluate the efficacy and safety of BC caps for women with abnormal vaginal discharge due to microbial infections: case series." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 4 (March 25, 2022): 1276. http://dx.doi.org/10.18203/2320-1770.ijrcog20220918.
Full textAbstract:
Herbal therapeutics advancement demand in management of abdominal vaginal discharge is increasing in women as it serves as an important housekeeping function in the reproductive system. This case series study evaluates the safety and effectiveness of birth control contraceptives capsules (BC caps) in women suffering from abnormal vaginal discharge. We conducted an open label interventional study of 15 female patients with in the age of 18-45 years (mean 33.7 years) with a history of abnormal vaginal discharge. Patients were asked to administer two BC caps (neem seed oil) capsule of 500 mg manually to vagina daily at night for 15 days followed by treatment assessment as per each schedule visit. Primary outcome includes change in microbiological parameters. Secondary outcomes included monitoring of adverse event (AE) and serious adverse event (SAE), changes in clinician’s assessment of symptoms and change in Subject’s global assessment of symptoms. The study showed the 93.33% and 87.5% improvement in abnormal vaginal discharge and cervical abnormalities. Microbiological cure rate found was 100% for pathogens. A constant decline was seen in the mean values of all the associated symptoms. Significant results in whiff and pH test were observed after treatment. The vaginal discharge was observed to be clear in 100% of the participants. Subject’s assessment of symptoms which were low back pain, vulval itching, general weakness, foul discharge, and burning sensation were improved. All results were significant at p value <0.05. The study found that BC caps is highly effective and safe in a treatment for abnormal vaginal discharge. It also showed improvements on associated symptoms with minimal to zero side effects.
28
Kowsari, Mst Mosfika, Most Merina Akhter, Mst Shaheen Nawrozy, Shahela Jesmin, Md Zalal Uddin, and Hasan Md Abdur Rahim. "Socio-Demographic Aspects of Complicated Induced Abortions." TAJ: Journal of Teachers Association 31, no. 2 (May 29, 2019): 63–67. http://dx.doi.org/10.3329/taj.v31i2.41604.
Full textAbstract:
Worldwide millions of women seek induced abortion. When successful and complete, it remains secret and if complicated gets highlighted. Hospital data represents a tip of the ice berg. It is an important cause of maternal morbidity and mortality but is preventable. This study was done to have a view to some socio-demographic aspects of induced abortion. This study was conducted from January 2012 to July 2012. Patients admitted with illegal induced abortion (N=50) were included in this study. Patients with spontaneous abortions were excluded. Data was collected using pre-designed data collection sheet and were expressed as actual number and percentage. Age range was 15-45 years with maximum incidence in 25-35 years. Peri-urban & rural area were the maximum habitat. Majority patients and their husbands were illiterate or only had primary level education. Most of them were housewives and majority of their husbands were day laborers or small-business holders. Most of their knowledge about different contraceptives was poor and knowledge of MR services was uncertain or none. 96% of their pregnancies were unwanted. Abortions were induced at local clinic, at own residences or at inducers’ residence. Methods of abortion induction were MR, drugs or herbal agents. Abortions were induced by nurse, respondents herself, ‘dai’ or by midwives; none by physician or well trained personnel. One (2%) patient died due to haemorrhage and sepsis. Rural, illiterate persons of our community with little or poor knowledge of family planning services are at risk of having unwanted pregnancy. And, poor knowledge regarding MR or related facilities, as well as legal restriction provokes them to induce abortions by poorly trained personnel and thereby endangering their lives.
TAJ 2018; 31(2): 63-67
29
Nora, Hilwah, Rajuddin, Hafizudin, Rachmad Suhanda, and Ima Indirayani. "Curcumin, a potential oral herbal male contraceptive: a review article." Bali Medical Journal 12, no. 1 (December 14, 2022): 82–86. http://dx.doi.org/10.15562/bmj.v12i1.3937.
Full textAbstract:
Background: Worldwide, the population explosion and unintended pregnancies pose serious health issues. The family planning program is a vital element due to reducing population growth. Demographic data and family planning in Indonesia report that contraceptive use rates are 93.66% for women and 6.34% for men. Men's participation in family planning programs remains low, with options limited to vasectomy and condoms. Limited contraceptive options may explain the low participation rate. WHO recommends traditional medicine as a cost-effective substitute for manufactured medicines. The primary ingredient in turmeric, Curcumin, has antiviral, antibacterial, anti-inflammatory, and anticancer activities. In both animal and human clinical trials, it has demonstrated a lack of toxicity. Little research has been done on how it affects the male reproductive. Objective: This article reviews the literature regarding the effects of Curcumin in Curcuma Longa on male fertility. Conclusion: Curcumin in Curcuma Longa causes noticeable changes in the male reproductive system that reverse when treatment is discontinued. Therefore, Curcumin may potentially control male fertility as a male contraceptive.
30
Moroole, Molelekwa Arthur, Simeon Albert Materechera, Wilfred Otang-Mbeng, Rose Hayeshi, Cor Bester, and Adeyemi Oladapo Aremu. "Phytochemical Profile, Safety and Efficacy of a Herbal Mixture Used for Contraception by Traditional Health Practitioners in Ngaka Modiri Molema District Municipality, South Africa." Plants 11, no. 2 (January 12, 2022): 193. http://dx.doi.org/10.3390/plants11020193.
Full textAbstract:
The use of medicinal plants for contraception remains a common practice among South African ethnic groups. The present study assessed the phytochemical profile, cytotoxicity, acute oral toxicity and efficacy of a herbal mixture used for contraception by the Batswana of South Africa. An aqueous extract was prepared from equal quantities (in terms of weight) of Bulbine frutescens (roots), Helichrysum caespititium (leaves) and Teucrium trifidum (leaves) based on a recipe used by traditional health practitioners. The phytochemical profiles of the freeze-dried herbal mixture were analyzed using gas chromatography–mass spectrometry (GC-MS). In addition, cytotoxicity was determined using an MTT assay on Vero cells and in vivo contraceptive efficacy was evaluated using seven Sprague Dawley rats per control and treatment groups. The control group received distilled water while test groups received 5, 50 and 300 mg/kg of the herbal mixture, which was administered orally once a day for three consecutive days. Subsequently, female rats were paired 1:1 with males for 3 days. Their weights were measured weekly and incidence of pregnancy was recorded. The GC-MS chromatogram revealed the presence of 12 identified and 9 unidentified compounds. In terms of safety, the herbal mixture had an IC50 value of 755.2 μg/mL and 2000 mg/kg, which was the highest tested dose that caused no mortality or morbidity in the rats. A contraceptive efficacy of 14.5% was exerted with 50 mg/kg herbal mixture extract while other doses had no effects given that all the rats were pregnant. Based on a chi-square test (p < 0.05), there was no correlation between the tested herbal mixture doses and contraception, nor on the weight of the rats. Overall, the herbal mixture extract was found to be safe but had limited contraceptive efficacy at the tested doses. In future studies, exploring increased dose range, solvent extract types and hormonal analysis will be pertinent.
31
Veri, Nora. "PERAN TEH HIJAU TERHADAP OVARIUM, ENDOMETRIUM DAN AORTA TIKUS YANG DIPAPAR DEPOMEDROXY PROGESTERONE ACETATE (DMPA)." Jurnal Kebidanan Malahayati 7, no. 3 (July 31, 2021): 568–75. http://dx.doi.org/10.33024/jkm.v7i3.4255.
Full textAbstract:
Background: The type of injectable contraceptive that is currently widely used is Depo Medroxyprogesterone Acetate (DMPA) which contains the hormone progestin, which is a synthetic material from progesterone. The use of progestin contraceptives can reduce endometrial proliferation and increase apoptosis in endometrial tissue. Cell apoptosis is triggered by an imbalance between positive signals (cell growth factors) and negative signals (DNA damage and increased levels of oxidants) under conditions of oxidative stress. Apoptosis of oocytes in large numbers will cause tissue damage which is characterized by atrophy of the ovaries and causes decreased reproductive function. Oxidative stress can be overcome with endogenous and exogenous antioxidants to reduce free radicals in the body. Green tea is one of the herbal plants that act as antioxidants and phytoestrogens, through the polyphenol compounds contained therein.Purpose: To know the role of green tea in providing protective effects on the ovaries, endometrium and aorta in rats.Methods : The research design used in this study was a true experiment with a post test only control group design approach. In this study, the researchers treated green tea extract at a dose of 10.8 mg/rat/day, 21.6 mg/rat/day, and 43.2 mg/rat/day and exposure to DMPA at a dose of 2.7 mg/rat/day. Green tea extract was administered orally for 28 days. The research hypothesis is that green tea can increase the number of follicles, the number of endometrial glands and reduce the arteriosclerosis score of blood vessels. The preparations were stained by the Hemotoxin-Eosin (HE) method and using the OlyVIA software.Result: There was a significant decrease in the number of corpus luteum, endometrial glands and arteriosclerosis scores due to DMPA exposure but not on the number of follicles. Green tea extract was able to increase the number of endometrial glands at a dose of 10.8 mg/day, but there was no significant difference between doses. Green tea extract was able to reduce arteriosclerosis scores, but the most effective dose was 43.2 mg/day.Conclusion: DMPA exposure was able to significantly reduce the number of corpus luteum, the number of endometrial glands and arteriosclerosis score, but there was no significant difference in the number of primary, secondary, tertiary and de Graff follicles, there was a difference in the number of corpus luteum in the group exposed to DMPA, green tea extract was able to increase the number of endometrial glands and decrease the arteriosclerosis score.Suugestion It is necessary to determine the phase of the reproductive cycle before calculating the number of follicles and examining the level of the hormone estrogen to determine whether the experimental animal has become a hypoestrogen model or not. Keywords : Progesterone, Contraception, Green Tea, Antioxidant ABSTRAK Latar Belakang : Jenis kontrasepsi suntik yang saat ini banyak digunakan adalah Depo Medroxyprogesterone Acetate (DMPA) yang mengandung hormon progestin yaitu bahan sintestis dari progesteron. Penggunaan kontrasepsi progestin dapat menurunkan proliferasi endometrium dan meningkatkan apoptosis pada jaringan endometrium. Apoptosis sel dipicu karena adanya ketidakseimbangan antara sinyal positif (faktor pertumbuhan sel) dan sinyal negatif (kerusakan DNA dan peningkatan kadar oksidan) pada kondisi stress oksidatif. Apoptosis pada oosit dalam jumlah yang besar akan mengakibatkan kerusakan jaringan yang ditandai dengan terjadinya atrofi pada ovarium dan menyebabkan fungsi reproduksi menurun. Stress oksidatif dapat diatasi dengan antioksidan endogen dan eksogen untuk menurunkan radikal bebas dalam tubuh. Teh hijau merupakan salah satu tanaman herbal yang berperan sebagai antioksidan dan fitoestrogen, melalui senyawa polifenol yang terkandung didalamnya.Tujuan : Mengetahui peran teh hijau dalam meberikan efek protektif terhadap ovarium, endometrium dan aorta pada tikus.Metode : Rancangan penelitian yang digunakan dalam penelitian ini adalah true experiment dengan pendekatan post test only control group design. Dalam penelitian ini perlakuan peneliti adalah pemberian ekstrak teh hijau dengan dosis 10,8 mg/tikus/hari, 21,6 mg/tikus/hari, dan 43,2 mg/tikus/hari dan paparan DMPA dosis 2,7 mg/tikus/hari pada tikus. Ekstrak teh Hijau diberikan secara oral selama 28 hari. Hipotesis penelitian adalah teh hijau mampu meningkatkan jumlah folikel, jumlah kelenjar endometrium dan menurunkan skor arteriosklerosis pembuluh darah. Preparat diwarnai dengan metode Hemotoxin-Eosin (HE) dan menggunakan software OlyVIA.Hasil : Terjadi penurunan jumlah korpus luteum, kelenjar endometrium dan skor arteriosklerosis akibat paparan DMPA secara bermakna namun tidak pada jumlah folikel. Ekstrak teh hijau mampu meningkatkan jumlah kelenjar endometrium pada dosis 10.8 mg/hari, namun tidak ada perbedaan yang signifikan antar dosis. Ekstrak teh hijau mampu menurunkan skor arteriosklerosis, namun yang paling efektif adalah dosis 43.2 mg/hari.Kesimpulan : Paparan DMPA mampu menurunkan jumlah korpus luteum, jumlah kelenjar endometrium dan skor arteriosklerosis secara bermakna, namun tidak ada perbedaan yang bermakna pada jumlah folikle primer, sekunder, tersier dan de Graff, ada perbedaan jumlah korpus luteum pada kelompok yang dipapar DMPA, ekstrak teh hijau mampu meningkatkan jumlah kelenjar endometrium dan menurunkan skor arteriosklerosis.Saran Perlu menentukan fase siklus reproduksi sebelum dilakukan perhitungan jumlah folikel dan pemeriksaan kadar hormon estrogen untuk menentukan apakah hewan coba sudah menjadi model hypoestrogen atau belum. Kata Kunci : DMPA, Kontrasepsi, Teh Hijau, Antioksidan
32
Hlengwa, Nokulunga, Christo J. F. Muller, Albertus K. Basson, Sandra Bowles, Johan Louw, and Charles Awortwe. "Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport." Phytotherapy Research 34, no. 7 (February 3, 2020): 1519–29. http://dx.doi.org/10.1002/ptr.6623.
Full text
33
Hosseinkhani, Ayda, Fatemeh Tabatabaei, Maryam Mosaffa-Jahromi, and Mehdi Pasalar. "Urinary Bladder Stone Passing Using a Persian Herbal Recipe." Journal of Evidence-Based Integrative Medicine 23 (January 1, 2018): 2515690X1876571. http://dx.doi.org/10.1177/2515690x18765715.
Full textAbstract:
Objective. The intrauterine device (IUD) is a popular contraceptive instrument with reported complications. IUD migration to the urinary bladder, a rare genitourinary tricky situation, may cause stone formation and result in urinary system sequels such as a stone formation and a recurrent infection. Case Report. This is a case report of IUD migration to the urinary bladder, mineralization, and subsequent complications. We report the case of a 35-year-old woman with a copper IUD nidus stone in her urinary bladder. She received a Persian medicine formulation including goat’s head, cornflower, silk corn, field horsetail, cumin, black Spanish radish, and common dandelion. She passed an oxalate stone 3 days later. Conclusion. Inexpensive common traditional recommendations might be helpful in current obstetrics and gynecology practice in our region.
34
Zakarija, Anaadriana, Nicholas Bandarenko, Dilip K. Pandey, Hau Kwaan, Kathryn McCaffrey, Denise Finley, Ken Carson, Paul Yarnold, and Charles L. Bennett. "Preliminary Findings from the Prospective Multicenter Surveillance, Epidemiology and Risk Factors for Thrombotic Thrombocytopenic Purpura (SERF-TTP) Study." Blood 104, no. 11 (November 16, 2004): 855. http://dx.doi.org/10.1182/blood.v104.11.855.855.
Full textAbstract:
Abstract Background: Due to the rarity of TTP (approximately 4 cases per million), epidemiologic data and correlative laboratory samples from a prospectively identified incident cohort of TTP patients are needed. Methods: SERF TTP is a NHLBI-funded 15-site study targeted to identify 300 incident TTP patients and 600 age-/gender-matched community controls. Results: From nine IRB-approved collaborating sites, 22 incident TTP cases and 17 controls have been interviewed. Data and plasma (acute and convalescent samples) are available for 19 TTP patients (Table 1). Their mean age is 42.5 years (range, 20 – 80 years), and 90% are female. Using the Rose-Eldor TTP Scoring system based on platelets, creatinine, hemoglobin, and neurologic function, 37% would be classified as severely ill (score > 4 of a maximum 8 points). Mean time from symptom onset to diagnosis was 9.2 days, median 5.5 days (range, 0 to 33 days). Severity of TTP was poorer for the 5 patients whose treatment did not begin for at least 16 days (16–33 days) versus the other 14 patients (mean Rose-Eldor score of 4.6 versus 4). Medications which had been prescribed to the patients prior to TTP onset included herbal supplements (n= 5) and hormone replacement therapy or oral contraceptives (n= 6). All patients received at least daily therapeutic plasma exchange (TPE). A platelet count >150,000 was reached at a mean of 9.4 days following TPE initiation. At 30-days follow-up, all patients were alive, although 3 had an exacerbation requiring daily TPE reinstitution. Fourteen patients (78%) experienced an adverse event, including allergic reactions to plasma (n=9), citrate-related toxicity (n=9) and venous access complications (n=2) including one with major hemorrhage requiring transfer to the intensive care unit. Conclusion: The clinical characteristics of the SERF-TTP cohort are similar to those reported from large single-site studies, although the survival rate (100% versus 71% and 83%) is higher. Only a minority of incident TTP cases in the modern era present with renal insufficiency or neurologic findings - highlighting the importance of developing reliable diagnostic laboratory testing. Clinical Characteristics at Presentation Study Platelets <100,000 Hgb <10 or Hct <.3 Cr > 2mg/dl Fever Neurologic symptoms Mortality (1) Zheng XL, Kaufman RM et al. Blood.2004; 103: 4043; (2)Vesely SK, George JN et al. Blood.2003; 102: 60. HSCT: Hematopoetic stem cell transplantation, FK-506: Tacrolimus. SERF-TTP n=19 95% 79% 32% 11% 47% 0% Washington University (1) (excluding HSCT/FK506 cases) n= 28 96% 82% 29% 32% 50% 29% Oklahoma TTP-HUS Registry (2) (ADAMTS13 < 5%) n=18 100% 100% 22% NA (Not Available) 56% 17%
35
Sharma, Aman Kumar, Tarun Garg, Goutam Rath, and Amit K. Goyal. "Development of Trans Cinnamon Aldehyde Loaded Multiple Emulsion: Herbal Contraceptive Microbicide Formulation." Journal of Colloid Science and Biotechnology 5, no. 1 (March 1, 2016): 90–99. http://dx.doi.org/10.1166/jcsb.2016.1137.
Full text
36
Duraisamy, Ramasamy, Shakila Kalaivanan, and Meera Devi Sri Paramashivam. "Development of pharmacopoeial standards and HPTLC chromatographic finger print analysis of the roots of Hibiscus vitifolius Linn." Journal of Scientific and Innovative Research 4, no. 4 (August 25, 2015): 182–86. http://dx.doi.org/10.31254/jsir.2015.4405.
Full textAbstract:
Herbal medicines have a long therapeutic history and are still serving many of the health needs of a large population of the world. However, the quality control and quality assurance still remains a challenge because of the high variability of chemical components involved. Herbal drugs, singularly and in combinations contains numerous active compounds responsible for the overall efficacy. This creates a challenge in establishing the standardization of herbal drugs and finished products. Hibiscus vitifolius Linn., family Malvaceae, is widely distributed in tropical and subtropical regions of the world. The roots of the plant are demulcent, contraceptive and used in the treatment of pulsating anterior fontanelle in babies and kidney problems. In view of its medicinal importance it becomes necessary to evaluate the physic-chemical parameters, preliminary phytochemical analysis and TLC/HPTLC finger print analysis of n-hexane, chloroform, ethyl acetate and ethanol extracts. TLC and HPTLC finger print profiles for the various extracts of H. vitifolius can be used as a quality control tool. These profiles can be used for rapid identification, monitoring the purity and detection of adulterants. This will help in confirming the genuinity of the material.
37
Ojha, Mithlesh, Neha Meshram, Ajay Singh, Amit Alexander, Ajazuddin, and Mukesh Sharma. "The Scope of Herbal Plants as the Source of Contraceptive Values in Males." Asian Journal of Research in Pharmaceutical Science 5, no. 1 (2015): 59. http://dx.doi.org/10.5958/2231-5659.2015.00010.7.
Full text
38
Srivastava, Shobha Rani, Saurabh Kesarwani, Govind Keshri, and Man Mohan Singh. "Evaluation of contraceptive activity of a mineralo-herbal preparation in Sprague-Dawley rats." Contraception 72, no. 6 (December 2005): 454–58. http://dx.doi.org/10.1016/j.contraception.2005.05.026.
Full text
39
Hoque, Tania. "A case report of Acne Vulgaris: Treated by combination of Acupuncture." Dermatology and Dermatitis 3, no. 1 (October 1, 2018): 01–02. http://dx.doi.org/10.31579/2578-8949/042.
Full textAbstract:
A 23years of female patient came at Gonosashthaya Somaj vittik Medical college, Savar 1yr back with the complains of – Multiple papulo-pustular scattered lesions over face, neck and back for 5-6yrs She was diagnosed as a known case of Acne Vulgaris 2yrs back And treated here with anti-acne medicine for 1yr. Past history - She got no history of allergy, asthma Personal history – She took lots of cosmetics and herbal products for her fairness. She is married for 5yrs and have one female healthy child of 3yrs; she never took any contraceptive method.
40
Ariani, Novida, Hikmawan Wahyu Sulistomo, and Yolanda Eldamayanti. "Pengaruh Ekstrak Etanol Daun Inggu (Ruta angustifolia) terhadap Tebal Otot Polos Tuba Fallopi Tikus Strain Wistar Betina." Journal of Issues in Midwifery 6, no. 3 (December 30, 2022): 139–47. http://dx.doi.org/10.21776/ub.joim.2022.006.03.3.
Full textAbstract:
The highest drop out of hormonal contraceptive users caused by side effects is the background for research on the use of herbal plants as antifertility substitutes for hormonal contraceptive which have minimal effects. Inggu leaves (Ruta angsutifolia) contain compounds that are interfering hormonal work such as saponins, tannins, chalepins and chalepensins, so it can be antifertitlity. To determine ethanol extract of inggu leaves effect on reducing the thickness of the smooth muscle of fallopian tube in female rats. The study used randomized post-test only controlled group was conducted using experimental animals (Wistar strain rats) divided into 4 groups with different doses (0; 0.4; 0.8; and 1.2 g/kg BW ) in February until April 2022. Measurement of the fallopian tube smooth muscle layer thickness using an Olympus CX23 microscope and ImageJ application.: Rat fallopian tube smooth muscle thickness was reduced along the dose of inggu leaf ethanol extract increased that statistically significant (p = 0.046). Ethanol extract of inggu leaves can reduce the fallopian tube smooth muscle thickness with an optimal dose of 1.2 g/kg BW.
41
Sundar Rajan, T., I. Sarathchandiran, and B. Kadalmani. "Evaluation of anti-fertility activity of herbal oral contraceptive suspension on male Wistar albino rats." Journal of Pharmacy Research 7, no. 4 (April 2013): 342–46. http://dx.doi.org/10.1016/j.jopr.2013.04.021.
Full text
42
Firdaus, Muhammad Feraldi, Agung Janika Sitasiwi, and Siti Muflichatun Mardiati. "Efek Ekstrak Air Biji Pepaya (Carica papaya L.) terhadap Fertilitas Mencit (Mus musculus L.) Betina." Jurnal Sain Veteriner 35, no. 2 (April 12, 2018): 223. http://dx.doi.org/10.22146/jsv.34688.
Full textAbstract:
Papaya seeds were known as medicinal plant which have anti-fertility potencies. So it could be used as a herbal contraceptive. The purpose of this study was to test the anti-fertility effect of Papaya seed water extract on mice (Mus musculus L.) fertility which proved by pregnancy rate, litters number and sex ratio of litters. This study was designed by Completely Randomized Design, using 15 female Swiss Webster mice that were divided into 5 treatment groups with triplicates. The K(-) group were treated by distilled water; K(+) group were treated by contraceptive pills; P1, P2, P3 groups that were treated by papaya seeds extract with 1.4, 3.5 and 7 mg/animal/day respectively. Each treatment was given orally with 0.5 ml in volume for 21 days. At the end of treatment, mice was mated. The observed parameters were pregnancies occurence, litters number and sex ratio of the litters. The litters number data were analyzed by Analysis of Variance. The results showed there was differences in pregnancy time and sex ratio between control and treatment groups, but there was not significantly different in litters number. It could be concluded that the fertility of mice was inihibited by water extract of papaya seeds.
43
Zaman, Wajid, Mushtaq Ahmad, Muhammad Zafar, Hafiza Amina, Lubna, Fazal Ullah, Saraj Bahadur, et al. "The quest for some novel antifertility herbals used as male contraceptives in district Shangla, Pakistan." Acta Ecologica Sinica 40, no. 1 (February 2020): 102–12. http://dx.doi.org/10.1016/j.chnaes.2019.05.017.
Full text
44
Chabibah, Ike Fitrah Atul, and Yekti Satriyandari. "Determinants of Traditional Contraceptive use among Women." Women, Midwives and Midwifery 2, no. 1 (February 17, 2022): 1–19. http://dx.doi.org/10.36749/wmm.2.1.1-19.2022.
Full textAbstract:
Background: Population growth in Indonesia remains high and itconstitutes a population problem which requires the enactment of population policy, namely by reducing the growth rate as low as possible through the family planning programs. 3.8% of women of childbearing age (WCA) in Indonesia still choose to use the traditional family planning methods, including the use of natural ingredients or herbal medicine as the traditional contraception, the use of coitus interruptus method, and the use of calendar method which is lower in effectiveness than modern contraceptive methods. Purpose: The purpose of this study is to review determinants of traditional contraceptive use among women. Methods: Four databases were used to organize this scoping review, namely PubMed, JSTOR, Science Direct, and Google Scholar. These databases wereconsidered to be relevant on condition thatthe scoping review research questions could be answered through the search ofarticles using keywords. To obtain the relevant articles, the inclusion and exclusion criteria were set, then the articles were selected through the PRISMA flow chart. After that, a critical appraisal was conducted to assess the quality of each article, the articles were further condensed using data charting, an evidence-based analysis was compiled, and the results were reported. Results: This study resulted in thefinding of 9 theme-related articles whose research characteristics consisted of grade A for 6 articles, grade B for 1 article, which all employed cross sectional research method, and grade Good for 2 qualitative design articles.These articles were obtained from developing countries. The limitation of this study was that not all factors contained in the collection of articles were discussed by the researchersdue to the lack of comparison journals which matched the theme. Conclusion: The results of scoping review from the titledeterminants of traditional contraceptive use among womenrevealed that there were several related factors including age, education level, economic status, parity, husband’s support, culture and information systems. Based on the 9 articles in this scoping review, the research results on factors related to the use of traditional family planningmethods were supported. However, not all factors such as sexual behavior, smoking, religious prohibitions, health problems and service quality could be studied in depth due to the limited comparison journals. Therefore, the researchers expect that further research can cover all factors related to the use of traditional family planning methods in order to develop knowledge concerning the traditional contraceptive use, and it is expected that the results of this studycanserve the material for government policy making in future family planning programs.
45
Kutney, James P., Gary M. Hewitt, Gin Lee, Krystyna Piotrowska, Malcolm Roberts, and Steven J. Rettig. "Studies with tissue cultures of the Chinese herbal plant, Tripterygiumwilfordii. Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activity." Canadian Journal of Chemistry 70, no. 5 (May 1, 1992): 1455–80. http://dx.doi.org/10.1139/v92-182.
Full textAbstract:
A detailed study of metabolites produced by the plant cell culture line of Tripterygiumwilfordii, a Chinese herbal plant, is presented. Eighteen compounds within the diterpene and triterpene families have been isolated and fully characterized. Of these, five are novel compounds, and their structures were determined by a combination of spectral analysis, chemical correlation and single crystal X-ray diffraction. The interest of these compounds in the treatment of rheumatoid arthritis, skin allergies, and for male contraception is noted.
46
Redvers, A., R. Laugharne, G. Kanagaratnam, and G. Srinivasan. "How many patients self-medicate with St John's wort?" Psychiatric Bulletin 25, no. 7 (July 2001): 254–56. http://dx.doi.org/10.1192/pb.25.7.254.
Full textAbstract:
Aims and MethodSt John's wort is popularly taken as a herbal remedy, but it interacts with prescribed drugs. The aim of this survey was to estimate the prevalence of patients self-medicating with St John's wort. All new referrals to a community mental health team over 5 months were asked about any use of St John's wort.ResultsFifteen patients, of 101, had taken St John's wort at some time and of those seven were currently taking it. Patients who used St John's wort tended to be younger and female. Only nine of the 15 patients took it for depressive symptoms and none had received medical advice. One patient was taking an interacting medication.Clinical ImplicationsA significant number of patients are taking St John's wort. In order to prevent drug interactions, doctors should ask all patients whether they use it, especially young women who may be on the contraceptive pill. Patients need better education about its risks and benefits and it should be taken with medical advice.
47
Wilson, Robin Fretwell. "Essay: The Limits of Conscience: Moral Clashes over Deeply Divisive Healthcare Procedures." American Journal of Law & Medicine 34, no. 1 (March 2008): 41–63. http://dx.doi.org/10.1177/009885880803400102.
Full textAbstract:
Refusals by individual pharmacies and pharmacists to fill prescriptions for emergency contraceptives (“EC”) have dominated news headlines, from the Washington Post to the Miami Herald. In the act that sparked a firestorm of controversy, an Eckerd pharmacist refused to fill a rape victim’s prescription for Plan B. A few months later, 11 Alabama nurses resigned positions at state clinics rather than provide EC against their moral convictions. These refusals do not seem to be driven by moral concerns about promiscuity, since pharmacists have refused to dispense Plan B to married couples as well. Instead, the refusals reflect moral and religious concerns about facilitating an act that would cut-off a potential human life.
48
Beinner, Mark Anthony, and Rosana Passos Cambraia Beinner. "The profile of professionals in health and education fields at work in their communities." Ciência & Saúde Coletiva 9, no. 1 (2004): 77–83. http://dx.doi.org/10.1590/s1413-81232004000100008.
Full textAbstract:
Social roles mold attitudes of actors who play the part in the community, and affect behavioral and moral attitudes and social conscience. There is a diversity of behaviors that demonstrates the extension to which individuals are in constant participation in the community life. A group profile of professional's health and education may supply information on the disciplinary approach in Community Health. Objective: to examine the profile of professionals at work in the Health and Education fields. Subjects participated in answering questions concerning professional work, leisure/religious activities, feeding/sleep habits, prevention and contraceptive methods, medical and/or psychological treatment and medicine/herbal use. Characteristics of the professional group regarding life style and the paradox of the practice of safe sex behavior were recorded. There exists the possibility to improve the quality of life for people in communities by reducing the sources of stress and tension by promoting physical and mental health. Methods should be investigated to allow for the promotion of a quality of life in a small fraction of the population engaged in health and education work in their own communities.
49
Rahmawati, Hanifa Rizky, Eko Susetyarini, and Fendy Hardian Permana. "PRECLINICAL TEST CONDENSED TANNINS OF Pluchea indica DOSAGE BASED ON BEHAVIOURAL PARAMETERS OF MALE Rattus norvegicus AS CONTRACEPTIVE CANDIDATE." Jurnal Biosilampari : Jurnal Biologi 5, no. 1 (December 31, 2022): 97–110. http://dx.doi.org/10.31540/biosilampari.v5i1.1535.
Full textAbstract:
Herbal medicine's development as an antifertility agent is the condensed tannins of the leaves of beluntas (Pluchea indica). This study was to determine the safety of P. indica condensed tannin extract based on the behaviour of male Rattus norvegicus. This research design was qualitative descriptive with two weeks direct observation of animal models and scoring based on rats' behaviour parameters. Comparative research involving 24 white male rats based on negative control group (aquades), dose groups : I (0.4 ml/KgBW), II (2 ml/KgBW), and III (2 ml/KgBW and 3 ml/KgBW). Parameters observed were body posture, motoric activity, ataxia, righting reflex, gauze test, analgesia, ptosis, and respiratory death or cardiac arrest. The result showed a significant correlation between three of the eight parameters, namely body posture, motor activity, and ptosis based on the dose that had been given. The safe dossage as an antifertility candidate for humans was range I to dose II (0.4ml/KgBW-2 ml/KgBW) because it was included in the practically non-toxic category. Therefore, this research was important to make condensed tannins safe in their application as an antifertility drug for humans in the future.
50
Sharma, Shivam, Vineet Mehta, Parul Sharma, Kritika Jaggi, Malairaman Udayabanu, and Hemant Sood. "ANTIFERTILITY ACTIVITY AND CONTRACEPTIVE POTENTIAL OF THE HYDROALCOHOLIC RHIZOME EXTRACT OF TRILLIUM GOVANIANUM IN FEMALE WISTAR RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (November 7, 2018): 329. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27420.
Full textAbstract:
Objective: Trillium govanianum is used in several traditional containing steroids and sex hormones for the management of inflammation, menstrual disorders, sex-related disorders, and antiseptic. The present study was aimed to investigate the antifertility potential of hydroalcoholic rhizome extract of T. govanianum and to explore the possible mechanism of action. Methods: Anti-implantation activity of T. govanianum rhizome extract (125 and 250 mg/kg; p.o.) was performed in female Wistar rats with proven fertility, and its estrogenic/antiestrogenic effect was evaluated in ovariectomized females. 17-α-ethinylestradiol (1 μg/rat/day; s.c.) or plant extract was administered for 11 days after which animals were sacrificed. Percentage inhibition of implantation sites, serum estrogen levels, changes in body and uterus weight, and morphological alterations in the uterus and ovaries were evaluated. Results: T. govanianum treatment resulted in increased uterus weight and induced dose-dependent anti-implantation effect, with 100% implantation inhibition at 250 mg/kg dose. Anti-implantation effects of T. govanianum were associated with endometrial thickening and significantly elevated serum estrogen levels. Moreover, estrogenic/antiestrogenic studies revealed that T. govanianum possessed strong estrogenic effect; however, the effect was saturable. Conclusion: T. govanianum possesses antifertility activity which can be attributed to its strong estrogenic potential and uterine thickening. Moreover, it could find a clinical application as a safer and efficacious birth control herbal remedy.