Relevant bibliographies by topics / Herbal drug

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Herbal drug'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Herbal drug"

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Parvez, Mohammad K., and Vikas Rishi. "Herb-Drug Interactions and Hepatotoxicity." Current Drug Metabolism 20, no. 4 (June 11, 2019): 275–82. http://dx.doi.org/10.2174/1389200220666190325141422.

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Background: In recent times, herbals or phytomedicines have become very popular due to their global acceptance as a complementary and alternative remedy. While modern drugs are commercially available only after laboratory validations, clinical trials, as well as approval from drug regulatory authorities, majority of the marketed herbal products lack such scientific evidence of efficacy and safety. This results in herb or herb-drug interaction induced unfavorable clinical outcomes without crucial documentation on their temporal relations and concomitant use. Methods: An online literature search for peer-reviewed articles was conducted on the PubMed, Europe PMC, Medline and Google Scholar portals, using the phrases: complementary & alternative medicine, traditional Chinese medicine, herb-drug interaction, mechanisms of herb-drug interaction, herb-induced toxicity, herbal hepatotoxicity and causality, traditional medicine, viral hepatitis, etc. Results: The retrieved data showed that globally, patients are attracted to herbal remedies with the misconception that these are completely safe and therefore, use them simultaneously with prescription drugs. Notably, there exists a potential risk of herb-drug interactions leading to some adverse side effects, including hepatotoxicity. The toxicological effect of a drug or herb is due to the inhibition of drug metabolizing enzymes (e.g., cytochrome P450), including interactions with certain prescription drugs through various mechanisms. Several cases of hepatotoxicity due to use of herbals in viral hepatitis-related liver diseases have been recently reported. However, limited experimental data and clinical evidence on herbal pharmacokinetics hamper the evaluation and reporting of adverse reactions and the underlying mechanisms. Conclusion: Herb-drug interaction related morbidity is thus an emerging serious public health issue with broad implications for clinicians, pharmaceutical industries and health authorities. Nonetheless, despite increasing recognition of herb-drug interaction, a standard system for interaction prediction and evaluation is still nonexistent. This review article discusses the herb-drug interactions related hepatotoxicity and underlying mechanisms, including drug metabolizing enzymes and their regulation.
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Dülger, Gül. "Herbal drugs and drug interactions." MARMARA PHARMACEUTCAL JOURNAL 1, no. 16 (January 1, 2012): 9–22. http://dx.doi.org/10.12991/201216415.

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Chavhan, Sarin A., Sushilkumar A. Shinde, Sandip B. Sapkal, and Vinayak N. Shrikhande. "Herbal excipients in Novel Drug Delivery Systems." International Journal of Research and Development in Pharmacy & Life Sciences 6, no. 3 (April 2017): 2597–605. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(3).2597-2605.

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Choi, Min-Koo, and Im-Sook Song. "Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions." Pharmaceutics 13, no. 5 (April 23, 2021): 610. http://dx.doi.org/10.3390/pharmaceutics13050610.

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Gari, Manju, Lakhan Majhee, and Kavita Kumari. "HERBAL DRUG-INDUCED ADVERSE DRUG REACTION: A CASE REPORT." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (February 1, 2018): 9. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.22208.

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The present study done to focus many adverse drug reactions unrecorded with either patients failing to present to health services due to herbal medicine or no pharmacovigilance analysis is being made. In this case, a 55-year-old female patient with 41 kg weight, she received herbal treatment for gastritis and menstrual disturbance since November 2015. After administration of drug, she suddenly developed 23 small vesicles over neck and upper chest. Few vesicles ruptured over 4–5 days and few gradually increased in size to form bulla. The use of herbal drug has increased tremendously across the world in recent times. Hence, it has become important for pharmacovigilance of herbal drugs and adverse effect issues for the consumers and health-care professionals as it is complex to analyze these products than the conventional pharmaceuticals. “Safe” and “natural” cannot be used anonymously. Sufficient adverse drug monitoring of herbal drugs is as important as any other formularies.
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Patil, Rinku Y., Shubhangi A. Patil, Niranjan D. Chivate, and Yogesh N. Patil. "Herbal Drug Nanoparticles: Advancements in Herbal Treatment." Research Journal of Pharmacy and Technology 11, no. 1 (2018): 421. http://dx.doi.org/10.5958/0974-360x.2018.00078.1.

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Saini, Malvika, Manjula Manjula, and Mita Kotecha. "EVALUATION OF AN HERBAL ANTISEPTIC DRUG DELIVERY SYSTEM." Indian Research Journal of Pharmacy and Science 5, no. 1 (March 2018): 1324–37. http://dx.doi.org/10.21276/irjps.2018.5.1.11.

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Chhabra, Anshu, Gurvinder Singh, and Yash Upadhyay. "A Review on Herbal Drug Interaction." Asian Journal of Pharmaceutical Research and Development 8, no. 1 (February 14, 2020): 94–99. http://dx.doi.org/10.22270/ajprd.v8i1.663.

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Herbal medicines are becoming popular worldwide, despite their mechanisms of action being generally unknown, the lack of evidence of efficacy, and inadequate toxicological data. An estimated one third of adults in developed nations and more than 80% of the population in many developing countries use herbal medicines in the hope of promoting health and to manage common maladies such as colds, inflammation, heart disease, diabetes and central nervous system diseases. To date, there are more than 11 000 species of herbal plants that are in use medicinally and, of these, about 500 species are commonly used in Asian and other countries. These herbs are often co-administered with therapeutic drugs raising the potential of drug–herb interactions, which may have important clinical significance based on an increasing number of clinical reports of such interactions.The interaction of drugs with herbal medicines is a significant safety concern, especially for drugs with narrow therapeutic indices (e.g. warfarin and digoxin). Because the pharmacokinetics and/or pharmacodynamics of the drug may be altered by combination with herbal remedies, potentially severe and perhaps even life-threatening adverse reactions may occur. Because of the clinical significance of drug interactions with herbs, it is important to identify drugs and compounds in development that may interact with herbal medicines. Timely identification of such drugs using proper in vitro and in vivo approaches may have important implications for drug development.
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Aminova, Al'bina, Idris Yumaguzin, Niyaz Subhankulov, and Tatyana Sedykh. "Efficacy of a herbal drug in treating bovine mastitis." Agrarian Bulletin of the 209, no. 06 (July 15, 2021): 34–42. http://dx.doi.org/10.32417/1997-4868-2021-209-06-34-42.

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Abstract. Presently, mastitis is being addressed by biologically active agents of plant origin having a bactericidal, viricidal and immune-modulating effect. In this regard, the study of the Raido drug to treat different types of mastitis in lactating cows is of a certain scientific and practical importance. The aim of the study was to determine the efficacy of the Raido herbal drug against serous and catarrhal mastitis in cows during the lactation period. Research methods. Mastitis was detected according to clinical observations, with the results being confirmed by the express diagnosticum Mastidinum or a quick mastitis test. The blood morphological composition in terms of erythrocyte, leucocyte and haemoglobin content was analyzed on a haematological analyzer. Milk samples were examined bacteriologically for the pathogenic microflora. Results. Treating serous and catarrhal mastitis with the Raido herbal drug increased the level of erythrocytes and haemoglobin in recovering cows, reduced their leucocyte content in the peripheral blood, and somatic cells in milk more than doubled. There were no clinical signs of the disease on the fifth day when serving serous mastitis with 5 or 7 ml of the herbal drug intercisternally. Treating catarrhal mastitis with 10 and 12 ml of the drug using the same administration method produced a similar effect on the sixth day. Thus, the optimal dose for daily interstitial administration of serous mastitis was 5 ml and 10 ml for catarrhal mastitis. A comparison of the therapeutic effects of the phytomedicines Raido and Riposol revealed higher efficacy of the daily Raido use in these dosages. Scientific novelty. For the first time, the optimal dosage of the Raido herbal drug for intercisternal administration to cows with serous and catarrhal mastitis was determined; the therapeutic effect of the Raido herbal remedy was detected; a comparative assessment of the Raido and Riposol herbal remedies' effect in the treatment of serous and catarrhal mastitis was made.
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Pan, Si-Yuan, Shu-Feng Zhou, Si-Hua Gao, Zhi-Ling Yu, Shuo-Feng Zhang, Min-Ke Tang, Jian-Ning Sun, et al. "New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–25. http://dx.doi.org/10.1155/2013/627375.

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With tens of thousands of plant species on earth, we are endowed with an enormous wealth of medicinal remedies from Mother Nature. Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Because of the low success rate and huge capital investment need, the research and development of conventional drugs are very costly and difficult. Over the past few decades, researchers have focused on drug discovery from herbal medicines or botanical sources, an important group of complementary and alternative medicine (CAM) therapy. With a long history of herbal usage for the clinical management of a variety of diseases in indigenous cultures, the success rate of developing a new drug from herbal medicinal preparations should, in theory, be higher than that from chemical synthesis. While the endeavor for drug discovery from herbal medicines is “experience driven,” the search for a therapeutically useful synthetic drug, like “looking for a needle in a haystack,” is a daunting task. In this paper, we first illustrated various approaches of drug discovery from herbal medicines. Typical examples of successful drug discovery from botanical sources were given. In addition, problems in drug discovery from herbal medicines were described and possible solutions were proposed. The prospect of drug discovery from herbal medicines in the postgenomic era was made with the provision of future directions in this area of drug development.
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Dissertations / Theses on the topic "Herbal drug"

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Šiaudkulytė, Ieva. "Augalinių preparatų asortimento kitimo tendencijos Lietuvos vaistinėse." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133822-20854.

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Lietuvoje daugiausiai buvo užregistruota virškinimo sistemą veikiančių augalinės kilmės preparatų. Dažniausiai registruojamos augalinių vaistinių preparatų vaistų formos yra tabletės, lašai, tirpalai bei arbatos. Tarp augalinių preparatų Lietuvos vaistų registre vyrauja savo produkciją įregistravusios Lietuvos, Vokietijos bei Lenkijos įmonės. Tarp įmonių įregistravusių savo produkciją lyderiauja Lietuvos įmonės „Acorus Calamus“, „Švenčionių vaistažolės“, Lenkijos įmonė „Herbapol“ (iki 2000m.) bei Lietuvos įmonė „Valentis“ (2010m. ir 2013m.).
1994 – 2013 there were mainly registered drugs for digestive system. The most common herbal medicines registered drug forms are tablets, drops, solutions and tea. In Lithuania main drug companies are from Lithuania, Germany and Poland. Since 1994 most succssefull companies who had registered their products were Lithuanian companies “Acorus Calamus”, “Švenčionių vaistažolės”, Polish company “Herbapol” (until 2000) and Lithuanian company “Valentis” (2010 - 2013).
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Dube, Admire. "The design, preparation and evaluation of Artemisia Afra and placebos in tea bag dosage form suitable for use in clinical trials." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2915_1188480959.

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Artemisia Afra, a popular South African traditional herbal medicine is commonly administered as a tea infusion of the leaves. However, clinical trials proving it safety and efficacy are lacking mainly due to the absence of good quality dosage forms and credible placebos for the plant. The objectives of this study were to prepare a standardized preparation of the plant leaves and freeze-dried aqueous extract powder of the leaves, in a tea bag dosage form and to design and prepare credible placebos for these plant materials.

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Tian, Honglei. "A high throughput screening method for anti-cancer drug leads discovery from the herbal medicine /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202006%20TIAN.

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Wang, Li. "ASSESSMENT OF THE DRUG-DRUG INTERACTION POTENTIAL OF ANIONIC COMPONENTS IN THE DIET AND HERBAL MEDICINES ON ORGANIC ANION TRANSPORTERS (SLC22 FAMILY)." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3181.

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Numerous natural products are widely used as first-line/alternative therapeutics and dietary supplements in both western and eastern society. However, the safety and efficacy profiles for herbal products are still limited. Organic anion transporters (OATs; SLC22 family) are expressed in many barrier organs and mediate in vivo body disposition of a broad array of endogenous substances and clinically important drugs. As some dietary flavonoids and phenolic acids were previously demonstrated to interact with OATs, it is necessary to explore the potential interaction of such components found in natural products in order to avoid potential OAT-mediated drug-drug interactions (DDIs). The inhibitory effects of 23 natural products were assessed on the function of human (h) OATs, hOAT1 (SLC22A6), hOAT3 (SLC22A7), and hOAT4 (SLC22A11) and/or the murine (m) orthologs mOat1 and mOat3. For compounds exhibiting marked inhibition at initial screening, dose-response curves (IC50 values) and DDI indices were determined. At the initial screening concentrations, 14, 19, and 2 test compounds exhibited significant inhibition on hOAT1, hOAT3, and hOAT4, respectively. Additionally, all test Danshen (a Chinese herbal medicine) hydrophilic components significantly reduced mOat1- and mOat3-mediated substrate uptake at 1 mM. For selected compounds, the IC50 and Ki values were estimated to be in the micromolar or even nanomolar range. Considering the clinical plasma concentration and unbound fraction in plasma, DDI indices for gallic acid, gentisic acid, lithospermic acid, protocatechuic acid, rosmarinic acid, salvianolic acid B, and tanshinol indicated DDIs may occur in vivo in situations of co-administration of these compounds and clinical therapeutics known to be OAT substrates. Finally, a new, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to quantify gallic acid and gentisic acid in cell lysates in order to measure cellular uptake of these compounds in mOat1- or mOat3-expressing cells. Significant cellular uptake of gallic acid was observed in mOat1-expressing cells, compared with background control cells. The absorptive uptake was completely blocked by probenecid (known OAT inhibitor) at 1 mM. These results indicate that gallic acid is a substrate for mOat1 and suggest that human OAT1 might be involved in the active renal secretion of gallic acid.
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Jiang, Xuemin. "Effect of herbal medicines on the pharmacokinetics and pharmacodynamics of Warfarin in healthy subjects." University of Sydney. Pharmacy, 2004. http://hdl.handle.net/2123/651.

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Herbal medicines are widely used in our community. A survey of Australian consumers indicated that 60% had used complementary and/or alternative medicines in the past year with the majority not informing their doctor that they were using herbal medicines. Little is known about the potentially serious consequences of interactions between herbal and conventional medicines. Warfarin has an important role in treating people with heart disease, yet it has a narrow therapeutic range, is highly bound to plasma proteins, and is metabolised by cytochrome P450. This creates the potential for life-threatening interactions with other drugs and foods leading to excessive bleeding. Hence, warfarin is one of the most frequently investigated drugs for interaction studies. Early clinical reports suggest that there exists the potential for an interaction between warfarin and four herbal medicines: St John�s wort, ginseng, ginkgo and ginger. However, these herb-drug combinations have never been conclusively studied. The two clinical studies conducted as part of this research had an identical study design. Twenty-four healthy male subjects were recruited into the two separate studies. This was an open label, three-way crossover randomised study in twelve healthy male subjects, who received a single 25 mg dose of warfarin alone or after 14 days pre-treatment with St John�s wort, or 7 days pre-treatment with ginseng. Dosing with St John�s wort or ginseng was continued for 7 days after administration of the warfarin dose in study I or who received a single 25 mg dose of warfarin alone or after 7 days pre-treatment with recommended doses of ginkgo or ginger from single ingredient products of known quality. Dosing with ginkgo or ginger was continued for 7 days after administration of the warfarin dose in study II. Platelet aggregation, international normalised ratio (INR) of prothrombin time, warfarin enantiomer protein binding, warfarin enantiomer concentrations in plasma and S-7-hydroxywarfarin concentration in urine were measured in both studies. Statistical comparisons were made using ANOVA and 95% confidence interval (CI) for mean value and 90% CI for geometric mean ratio value are reported. n study I, the mean (95% CI) apparent clearance of S-warfarin after warfarin alone or with St John�s wort or ginseng were, respectively, 198 (174 � 223) ml/h, 269 (241 � 297) ml/h and 220 (201 � 238) ml/h. The respective apparent clearances of R-warfarin were 110 (94 � 126) ml/h, 142 (123 � 161) ml/h and 119 (106 � 131) ml/h. The mean ratio of apparent clearance for S-warfarin was 1.29 (1.16-1.46) and for R-warfarin was 1.23 (1.11-1.37) when St John�s wort was co-administered. The mean ratio of AUC0-168 of INR was 0.79 (0.70 - 0.95) when St John�s wort was co-administered. The urinary excretion ratio of S-7-hydroxywarfarin after administration of warfarin alone was 0.04 (0.03 � 0.06) mg/h and there was no significant difference following treatment with either St John�s wort 0.03 (0.02 � 0.04) mg/h or ginseng 0.03 (0.02 � 0.04) mg/h. The ratio of geometric means for S-7-hydroxywarfarin UER was 0.82 (0.61-1.12) for St John�s wort, and 0.68 (0.50-0.91) for ginseng. St John�s wort and ginseng did not affect the apparent volumes of distribution or protein binding of warfarin enantiomers. In study II, the mean (95% CI) apparent clearance of S-warfarin after warfarin alone, with ginkgo or ginger were 189 (167 � 210) ml/h, 200 (173 � 227) ml/h and 201 (171 � 231) ml/h, respectively. The respective apparent clearances of R-warfarin were 127 (106 � 149) ml/h, 126 (111 � 141) ml/h and 131 (106 � 156) ml/h. The mean ratio of apparent clearance for S-warfarin was 1.05 (0.98 -1.12) and for R-warfarin was 1.00 (0.93 -1.08) when co-administered with ginkgo. The mean ratio of AUC0-168 of INR was 0.93 (0.81 -1.05) when co-administered with ginkgo. The mean ratio of apparent clearance for S-warfarin was 1.05 (0.97 -1.13) and for R-warfarin was 1.02 (0.95 -1.10) when co-administered with ginger. The mean ratio of AUC0-168 of INR was 1.01 (0.93 -1.15) when co-administered with ginger. The urinary excretion ratio (UER) of S-7-hydroxywarfarin after administration of warfarin alone was 0.04 (0.03 � 0.05) mg/h and there was no significant difference following treatment with either ginkgo 0.04 (0.03 � 0.04) mg/h or ginger 0.03 (0.02 � 0.04) mg/h. The ratio of geometric means for S-7-hydroxywarfarin UER was 1.07 (0.69-1.67) for ginkgo, and 1.00 (0.64-1.56) for ginger. Ginkgo and ginger did not affect the apparent volumes of distribution or protein binding of either S-warfarin or R-warfarin. In conclusion, St John�s wort significantly induced the apparent clearance of both S-warfarin and R-warfarin, which in turn resulted in a significant reduction in the pharmacological effect of rac-warfarin. Ginseng, ginkgo and ginger at recommended doses affect neither clotting status, nor the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin in healthy subjects.
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Patel, Jignesh Mitra Ashim K. "P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of HIV-protease inhibitor, ritonavir, and its interaction with pure herbal constituents." Diss., UMK access, 2004.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2004.
"A dissertation in pharmaceutical science and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed Feb. 27, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 175-199). Online version of the print edition.
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Chan, Yuen Cheung. "Quality evaluation and anti-chronic glomerulonephritis properties of a patent herbal drug yi-shen-hua-shi granule." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/825.

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Yi-Shen-Hua-Shi (YSHS) granule is a Chinese patent drug for treating chronic glomerulonephritis (CGN). It was marketed in 2009. However, up to now, there is no report about the quality and pharmacological activities of this product. In this work，we evaluated the quality and anti-CGN effects of the drug. To evaluate the quality of the granule, a qualitative and quantitative HPLC-DAD analytical method was developed. For qualitative analysis, HPLC fingerprint of ten batches of YSHS granule was established. The fingerprints were analyzed using similarity evaluation, hierarchical cluster analysis (HCA), principal components analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) based on 15 characteristic fingerprint peaks. Similarity values of 10-batche samples were all above 0.960, indicating a stable quality. Minor differences were observed among batches by HCA and PCA. For quantification analysis, contents of six constituents in the granule were simultaneously measured. To establish the chemical profile of the granule, a HPLC-Q-TOF- MS/MS method was developed. A total of 105 peaks were detected using HPLC-Q-TOF-MS/MS in the granule, of which, 99 were tentatively identified as terpenoids, flavonoids, coumarins, alkaloids, phenols and other types of compounds, and 15 were further validated with reference substances. HPLC fingerprint chromatogram establishment, quantification analysis of 6 constituents and compound identification should improve the quality control of YSHS granule. To study the pharmacological activities of the granule, we investigated its anti-CGN effects and TGFβ signaling-related mechanism of action. A CGN rat model was established by injection of cationization-bovine serum albumin (C-BSA) for five weeks. After C-BSA injection, drugs were intragastrically administered to the rats once daily for four weeks. Clinical signs were recorded daily. Urine and serum biochemical parameters were analyzed using respective kits. Protein levels were examined by Western blotting. Pathological changes of renal tissues were evaluated using HE and Masson's trichrome staining. No significant differences in body weights and clinical signs were found among normal, model and drug treatment groups. Proteinuria; albuminuria; increased urine volume; elevated creatinine, urea nitrogen, triglyceride levels and total cholesterol in serum; decreased serum total protein and albumin; as well as renal pathological damages and fibrosis were observed in CGN model rats. YSHS granule ameliorated all the abnormal behavioral and biochemical changes in the model rats. Mechanistic investigations revealed that YSHS granule down-regulated proteins levels of TGFβ1, phospho-Smad2/3 (Thr 8) and Smad4 in rat renal tissues. These findings indicate that the drug has anti-CGN effects in rats, and inhibiting TGFβ signaling contributes to the underlying mechanisms. In summary, our chemical analytical studies will help in improving the quality control of YSHS granule. Our bioactivity and mechanistic studies provide a pharmacological basis for the clinical use of the granule in treating CGN.
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Ali, Viktoria. "Naturläkemedel inom sjukvården." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24309.

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Naturläkemedel är ett område som väcker stort intresse idag och allt fler individer väljer att ta hand om sina åkommor på egen hand. Modern forskning visar på interaktioner mellan naturläkemedel och konventionella läkemedel. Eftersom naturläkemedel under lång tid uteslutande har använts i egenvårdssyfte har patienters användning av dessa produkter skett i stor utsträckning utan medverkan från den vanliga hälso- och sjukvården. Syftet med denna studie var att undersöka sjuksköterskors inställning till och kunskaper om naturläkemedel. Studien är av kvalitativ design och är baserad på sex intervjuer med sjuksköterskor verksamma vid två ortopediska vårdavdelningar i Södra Sverige. Resultatet visade att behovet av ökade kunskaper om naturläkemedel hos sjuksköterskor är stort och att naturläkemedel är något som diskuteras i mycket liten omfattning inom sjukvården.
Herbal remedies is an area that arouses great interest today and more individuals choose to take care of their symptoms on their own. Modern research shows interactions between herbal remedies and conventional medicines. Since herbal remedies for a long time been used exclusively in self-care purposes, the patients use of these products are made largely without the participation of the ordinary health care. The purpose of this study was to investigate nurses attitudes towards and knowledge of herbal remedies. The design of this study is qualitative and is based on six interviews with nurses working in two orthopedic departments in southern Sweden. The results showed that the need for increased knowledge of herbal remedies among nurses is high and that herbal remedies are discussed in a very small scale in health care.
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Mazhar, Hajra. "The Use of Complementary and Integrative Medicines and Exploring Natural Health Product-Drug Interactions In Vitro in the Management of Pediatric Attention-Deficit Hyperactivity Disorder." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40653.

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This thesis applied a novel interdisciplinary approach for pharmacovigilance to examine the use of complementary and integrative medicine (CIM), focusing on herbal remedies, to manage pediatric attention-deficit hyperactivity disorder (ADHD). The safety and potential risk of herb-drug interactions in ADHD management were first evaluated through an assessment of available information on the safety and efficacy of natural health products (NHPs) commonly used by ADHD patients as a means of identifying knowledge gaps. A clinical questionnaire was administered to caregivers of pediatric patients with ADHD to determine the factors and related outcomes of CIM use, including adverse events. A systematic search was conducted to further identify clinical adverse events involving herbal remedies and ADHD drugs to determine causal links to herb-drug interactions. In vitro analysis of identified herbal remedies was conducted to determine their potential for pharmacokinetic interactions, specifically on carboxylesterase-1 (CES1) mediated metabolism. The presented research builds on otherwise scarce evidence of the safety of herbal remedies for ADHD, particularly with respect to herb-drug interactions and adverse events (AEs) associated with concurrent use of NHPs and ADHD prescription drugs. Beyond studies conducted on the pharmacokinetic safety of herbal remedies through the cytochrome P450 pathways that metabolize some ADHD drugs, including amphetamine, atomoxetine and guanfacine, few data were available for CES1, which metabolizes methylphenidate, the first line of drug used to manage ADHD. The clinical questionnaire revealed that 40% of patients had used CIM and confirmed the use of a variety of CIM. Moreover, the majority of CIM users were also concurrently taking ADHD medication, and eight mild adverse events were self-reported. The systematic search on the adverse event reporting system highlighted a potential NHP-drug interaction between methylphenidate and St. John’s wort, and the overall poor quality of NHP-related adverse event reports. As a follow-up from the adverse event results, various commercial St. John’s wort products showed variable inhibition of recombinant human CES1 in vitro. Although the concentration of marker phytochemicals was not correlated to inhibition, hyperforin showed stronger activity than hypericin and quercetin. The preliminary in vitro investigation revealed that the herbal remedies used by ADHD patients have the potential to interact with CES1 mediated metabolism, with Rhodiola rosea identified as the most potent inhibitor. Further investigation on various commercial products of Rhodiola rosea revealed both reversible and irreversible inhibition of recombinant CES1. However, the inhibition was not dependent on the concentration of marker phytochemicals, and rosarin, rosavin, rosin, and salidroside were not potent inhibitors of recombinant CES1. Moreover, a commercial Rhodiola rosea extract showed concentration-dependent inhibition of human liver microsome meditated metabolism of methylphenidate. Overall, results from this thesis suggest potential risk from use of NHPs concurrently with conventional medicine used to manage ADHD. Improved evidence and pharmacovigilance for the use of NHPs in a pediatric population is warranted.
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Ma, Ling. "Human Vγ9Vδ2 T cell immune responses towards congenital Toxoplasma gondii infection and mistletoe extract drug stimulation." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/313392.

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Vγ9Vδ2 T cells are the main circulating γδ T cells in human adult blood. They are known for their T cell receptor (TCR)-dependent recognition of microbe and endogenous-derived non-peptide pyrophosphate antigens (phosphoantigens, PAg). With the intrinsically biased type 1 immune responses, Vγ9Vδ2 T cells are an important force in the defense of infections and tumors. However, the immune responses of Vγ9Vδ2 T cells in early life infections and in immunotherapies are not clear yet. In this thesis, we explored Vγ9Vδ2 T cell immune responses in both aspects. Vγ9Vδ2 T cells are abundant in human fetal peripheral blood, but compared to their adult counterparts they have a distinct developmental origin, are hyporesponsive towards in vitro phosphoantigen exposure and they do not possess a cytotoxic effector phenotype. In order to obtain insight into the role of Vγ9Vδ2 T cells in the human fetus, we investigated in the first part of this thesis their responses upon in utero infection with the phosphoantigen-producing parasite Toxoplasma gondii (T. gondii). Most congenital infections are caused by viruses, T. gondii is one of the exceptions. The organelle apicoplast present in T. gondii can generate the most potent Vγ9Vδ2 T cell activator. Thus infection in utero with T. gondii makes it a good model to observe Vγ9Vδ2 T cell immune responses in early life. By comparing to age-matched controls, we found that fetal Vγ9Vδ2 T cells were highly expanded in congenital T. gondii infected newborns, and these expanded cells were highly differentiated towards potent cytotoxic effector cells. While the impact of congenital infection on Vγ9Vδ2 T cell expansion and function waned after birth, the Vγ9Vδ2 TCR repertoire of infected infants possessed a clear fetal footprint with public clonotypes, reflecting the Vγ9Vδ2 T cell response in utero. Indeed, verification of the antigen recognition related complementarity-determining region 3 (CDR3) of the TCR for γ and δ chain by high-throughput sequencing revealed the enrichment of three Vδ2 sequences in congenitally-infected infants that are already generated at 8 weeks of gestation. Vγ9Vδ2 T cells possess several characteristics, including MHC-independent recognition of tumor cells and potent killing potential, that make them attractive candidates for cancer immunotherapeutic approaches. In the second part of this thesis we investigated Vγ9Vδ2 T cell responses towards two kinds of hemiparasite plant Viscum album L. (European mistletoe) extract drugs in vitro. Mistletoe therapy is the most used complementary cancer therapy in European countries. Mistletoe extract drugs are considered to benefit for increasing the quality of life of cancer patients and modulate immune cells, but the mechanism of action is not clear. Here, we investigated in-depth the in vitro response of human T cells towards mistletoe extract drugs by analyzing their functional and TCR responses using flow cytometry and high-throughput sequencing respectively. Non-fermented mistletoe-extract drugs (AbnobaViscum), but not their fermented counterparts (Iscador), induced specific expansion of Vγ9Vδ2 T cells among T cells. Furthermore, AbnobaViscum rapidly induced the release of cytotoxic granules and the production of the cytokines IFNγ and TNFα in Vγ9Vδ2 T cells. This stimulation of anti-cancer Vγ9Vδ2 T cells was mediated by the butyrophilin BTN3A, did not depend on the accumulation of endogenous phosphoantigens and involved the same Vγ9Vδ2 TCR repertoire as those of phosphoantigen-reactive Vγ9Vδ2 T cells.In summary, in the first part of this thesis we showed that the human fetus intrinsically possesses a group of Vγ9Vδ2 T cells that are responding to congenital parasite infections that provide potential protective effects to the fetus. In the second part, we provided insight into the in vitro responses of Vγ9Vδ2 T cells towards mistletoe extract drugs, indicating that Vγ9Vδ2 T cells can be an important target in mistletoe therapy.
Doctorat en Sciences biomédicales et pharmaceutiques (Pharmacie)
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Books on the topic "Herbal drug"

1

Herbal drug dangers. Berkeley Heights, NJ: Enslow, 2000.

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Gurav, Shailendra S., and Nilambari S. Gurav, eds. Indian Herbal Drug Microscopy. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-9515-4.

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Herbal contraindications and drug interactions plus herbal adjuncts with medicines. 4th ed. Sandy, OR: Eclectic Medical Publications, 2010.

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International Conference on Folk and Herbal Medicine (2010 Udaipur, Rajasthan, India). Folk herbal medicine and drug discovery. Jodhpur: Scientific Publishers (India), 2012.

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Buhner, Stephen Harrod. Herbal antibiotics. 2nd ed. North Adams, MA: Storey Pub., 2012.

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Herbal drugs: Quality & chemistry. Houston, Tex: Studium Press, 2011.

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Joshi, D. D. Herbal drugs: Quality & chemistry. Houston, Tex: Studium Press, 2011.

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Green, James. The herbal medicine-maker's handbook: The art & science of herbal medicine-making as taught at the California School of Herbal Studies. Forestville, CA: Wildlife & Green Publications, 1990.

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International Symposium on Herbal Drug Research and Therapy (2006 Delhi, India). Recent advances in herbal drug research and therapy. Edited by Ray Arunabha, Gulati Kavita, and Vallabhbhai Patel Chest Institute. New Delhi: I.K. Int. Pub. House, 2010.

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Lily, Cheung, ed. Interactions between Chinese herbal medicinal products and orthodox drugs. Amsterdam: Harwood Academic, 2000.

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Book chapters on the topic "Herbal drug"

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Gurav, Shailendra, and Nilambari Gurav. "Herbal Drug Microscopy." In Indian Herbal Drug Microscopy, 15–196. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9515-4_4.

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Patil, Kalpana, and Raju Wadekar. "Herbal Drug Patenting." In Evidence Based Validation of Traditional Medicines, 555–88. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8127-4_27.

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Wang, Jufeng, Fanghua Huang, and Wei Li. "Herbal Medicine." In Drug Discovery and Evaluation: Pharmacological Assays, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_119-1.

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Wang, Jufeng, Fanghua Huang, and Wei Li. "Herbal Medicine." In Drug Discovery and Evaluation: Pharmacological Assays, 4251–58. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_119.

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An, Guohua, and Marilyn E. Morris. "Herbal Supplement-Based Interactions." In Enzyme- and Transporter-Based Drug-Drug Interactions, 555–84. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0840-7_22.

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Krasowski, Matthew D., and John L. Blau. "Drug Interactions with St. John's Wort." In Herbal Supplements, 273–90. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470910108.ch12.

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Tholpady, Ashok, and Semyon A. Risin. "Drug Interactions with Ginkgo Biloba and Ginseng." In Herbal Supplements, 321–31. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470910108.ch15.

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Abou-Diwan, Charbel, and James Ritchie. "Drug Interactions with Garlic and Ginger Supplements." In Herbal Supplements, 333–50. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470910108.ch16.

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Rakhmanina, Natella Y., and John N. van den Anker. "Drug-Herb Interactions in Patients with HIV/AIDS." In Herbal Supplements, 291–303. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470910108.ch13.

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Shinde, Devanand B., Machindra J. Chavan, and Pravin S. Wakte. "HPTLC in Herbal Drug Quantification." In High-Performance Thin-Layer Chromatography (HPTLC), 117–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14025-9_8.

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Conference papers on the topic "Herbal drug"

1

Drewe, J. "Translational research – an integral part of rational herbal drug development." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608559.

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Duan, Weigang, Qifeng Li, Ling Que, Jin Ke, Hua Yin, and Xiaoyue Xu. "Screening active components of herbal drug based on their affinity." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966183.

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Matthys, Heinrich, D. A. Pliskevich, Fathi A. Malek, Michael Tribanek, and Meinhard Kieser. "Add-on-therapy In COPD With An Herbal Drug Preparation." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4421.

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Duy, Pham Truong, Nguyen Minh Thanh, Nguyen Anh Vu, and Ly Le. "A machine learning approach for drug discovery from herbal medicine." In CSBio '17: 8th International Conference on Computational Systems-Biology and Bioinformatics. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3156346.3156352.

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Khan, S. "Activation of pregnane X receptor (PXR) by herbal supplements and risk of Herb-Drug Interactions." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608590.

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Chen, Jianxin, Shihuan Tang, and Hongjun Yang. "Discovering New Drug in Ancient Herbal Compound Database by Unsupervised Pattern Discovery Algorithm." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5162643.

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Hajjar, F., and O. G. Potanina. "JUSTIFICATION FOR THE CHOICE OF THE COMPOSITION OF THE COMBINED HERBAL DRUG OF SEDATIVE ACTION." In 90 лет - от растения до лекарственного препарата: достижения и перспективы. Москва: Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2021. http://dx.doi.org/10.52101/9785870191003_2021_515.

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Ismail Gadit, Zeenath, and Mathi Kandiah. "THE USE OF ANALYTICAL TECHNIQUES TO DETECT TOXIC SYNTHETIC DRUG, SIBUTRAMINE, ADULTERATED IN TRADITIONAL HERBAL MEDICINES." In International Conference on Bioscience and Biotechnology. The International Institute of Knowledge Management (TIIKM), 2017. http://dx.doi.org/10.17501/biotech.2017.2111.

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Sahlan, Muhamad, Katerina Evelyn, Diah Kartika Pratami, and Kamarza Mulia. "In vitro release study of sambiloto (Andrographis paniculata) extract encapsulated by casein micelle as anti-diabetic herbal drug." In PROCEEDINGS OF THE 5TH INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY 2019. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5134606.

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Okagu, Innocent, Joseph Ndefo, Christian Chibwuogwu, Emmanuel Aham, and Amarachukwu Onoh. "Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Rats by Deep Root Herbal Mixture®—A Nigerian Branded Polyherbal Drug." In The 1st International E-Conference on Antioxidants in Health and Disease. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/cahd2020-08562.

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Reports on the topic "Herbal drug"

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Shi, Zheng, Shun Yu, Renshou Chen, Wenxuan Xue, Yiqun Zhou, and Jiang Han. Bupleurum chinense herbal formula for the antituberculosis drug-induced hepatotoxicity : A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0088.

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Balabanova, Vessela, Yulian Voynikov, Gökhan Zengin, Reneta Gevrenova, and Dimitrina Zheleva-Dimitrova. A View on Antioxidant and Enzyme Inhibitory Activity of Senecio hercynicus Herbal Drugs. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2020. http://dx.doi.org/10.7546/crabs.2020.12.06.

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Liu, Liangshuai, Heping Li, Guosheng Tan, and Zhenjiang Ma. Traditional Chinese Herbal Medicine in Treating Amenorrhea Caused by Antipsychotic Drugs: Meta-analysis and systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0009.

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