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Dissertations / Theses on the topic 'Herbal therapeutics'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Rosenbaum, Christopher D. "Herbal Marijuana Alternatives Investigation: K2 and Spice: A Masters Thesis." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/578.

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Background Herbal marijuana alternatives (HMA), legal plant products adulterated with synthetic cannabinoid receptor agonists, represent a growing public health concern. Only a few case reports describe HMA and synthetic cannabinoid’s clinical toxicity. We describe an outbreak of HMA abuse primarily in the Midwest, the clinical presentation of HMA toxicity, and clinical and forensic testing. Methods During the course of ongoing surveillance for emerging drugs of abuse between November 2009 and August 2010, we retrospectively and prospectively identified a convenience sample comprising 81 cases

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2

Huang, Tao. "Toward novel therapeutics for functional constipation: from traditional Chinese medicine herbal formula MaZiRenWan to cyclic spexin analogues." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/388.

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Functional constipation (FC) is a major gastrointestional (GI) disorder which affects about 14% population worldwide. However, due to efficacy and safety concerns, more than 50% FC patients are not completely satisfied with current conventional therapies, thus alternative therapies are needed. A substantial part of FC patients have symptom of slow colonic motility, while therapy targeting a single pathway cannot benefit all of them. In this thesis, we searched for novel FC therapeutics from two distinct sources, both of which can improve colonic motility significantly: (1) MaZiRenWan (MZRW), a

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3

Cheng, Chung Wah. "Chinese herbal medicine for functional constipation." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1090.

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4

Au, Ching Tung Dawn. "Pharmacognostical studies on Hakka herbal medicine Wuzhimaotao." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/991.

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5

衛穎賢 and Wing-yin Eric Wai. "Effect of herbal medicine (Ganoderma lucidum) on nitric oxide production in macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3197126X.

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6

麥超常 and Chiu-sheung Simon Mak. "Efficacy of herbal medicine on neurodegenerative diseases: a systematic review." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738905.

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7

Wong, Wing Yan. "Proteomics analysis of anti-cancer effects of gynostemma pentaphyllum saponins in Apc min/+ colorectal cancer mouse model." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1421.

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8

Lok, Lap-kwan Marco, and 陸立羣. "The effect of herbal medicine on renal ischemia/reperfusion injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970722.

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9

Chen, Lei. "The impact of herbal saponins on gut microflora in animal models." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/55.

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Human gut harbors 100 trillion microbial organisms that is intrinsically linked to individual’s health and diseases, including cancer. Food fiber and phytochemicals such as polyphenols are considered as prebiotic-like dietary modifiers. They can influence the gut microbial communities, and in turn to modulate disease outcome and drug responses of the host. Saponins belong to a family of phytochemicals commonly found in many medicinal and edible plants. Herbal saponins have raised keen interest among scientists for their health-promoting effects, but have not been investigated for their potenti

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10

Tsang, Ting Fung. "Mechanistic study of Chinese herbal medicines on melanogenesis and anti-melanoma effects." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1506.

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11

Tian, Xiao Ying. "The study of Chinese herbal medicine in embryonic development of mice." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1071.

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12

Marnewick, Jeanine Lucasta. "Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/21888.

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Dissertation (PhD)--University of Stellenbosch, 2004.<br>ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing in vitro as well as in vivo carcinogenesis assays by: • Demonstrating the in vitro antimutagenic activity of aqueous extracts of the herbal teas against the metabolic activated mutagens, 2-acetylaminofluorene (2- AAF) and the mycotoxin, aflatoxin B1 (AFB,) as well as, to a certain extent, against the direct acting

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13

Zhang, Xiao, and 張瀟. "The effects of l-tetrahydropalmatine and rhynchophylline, alkaloids derived from herbal medicines, on cellular and molecular neurotoxicityof cocaine in PC12 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572248.

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14

Dube, Phumuzile. "The antimicrobial and associated antioxidant activity of rooibos (aspalathus linearis) and honeybush (cyclopia intermedia) herbal teas." Thesis, Cape Peninsula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2236.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2015.<br>The increase in antibiotic resistant bacterial and fungal infections and the prevalence of oxidative stress-related conditions including cancers, cardiovascular diseases and diabetes has led to a consensus among pharmaceutical companies, clinicians and researchers that novel antimicrobial and antioxidant approaches are needed. These should be ideally efficacious, non toxic, easily accessible and affordable. There has been an increased interest in the identification of medicinal plants that possess both th

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15

Cheung, Hoi-yan, and 張凱恩. "The study of Chinese herbal medicinal compound on implantation : in vitro spheroid-endometrium co-culture." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196547.

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Traditional Chinese medicine (TCM) plays an important role in the Chinese healthcare system for over five thousand years. It includes the use of herbal medicine, acupuncture, Tui Na (推拿), and diet therapy. TCM helps to maintain a balance of Yin-Yang (阴阳), Five Phases (五行), Meridians (经络) and Qi (气) inside the body. In practise, pregnant women take tocolytic drugs to tonify the blood and qi to provide a continuous supply of nutrients for baby. Traditional Chinese herbal medicines usually prescribed as a complex formula to produce synergistic or agonistic effect to maintain a well balance of

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16

Xie, Ying. "Studies on the quality control and pharmacokinetics of QFGJS capsule, an anti-arthritic Chinese herbal preparation." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/881.

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17

Keet, Lana. "Development of in vitro models to investigate the anti-inflammatory properties of Cyclopia Maculata and other South African herbal teas : a comparative study." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97030.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Chronic inflammation is suggested to contribute to cancer development and therefore a potential target for chemoprevention. In the skin, keratinocytes and macrophages play an integral part in acute and chronic inflammation, with interleukin 1-α (IL-1α) and tumor necrosis factor α (TNF-α) as key cytokines governing this process. Green tea (Camellia sinensis) and the South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) displayed antiinflammatory effects in mouse and human skin. To further in

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18

Seneca, Michael J. "Meta-Analysis of Herbal Cannabis Therapy for Chronic Pain." UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/503.

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Since the first so-called “medical marijuana” legislation was passed in California in 1996, a total of twenty states and the District of Columbia have passed laws permitting limited use of cannabis. Despite the changes in state laws, cannabis remains illegal for any purpose under federal law. Changes in state laws have coincided with a renewed interest in the substance for the treatment of a variety of conditions. There has been a significant increase in published data over the past twenty years examining the efficacy of cannabis as an appetite stimulant, antiemetic agent, and analgesic adjuva

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19

Cheng, Chi Yan. "Anti-arthritic properties of a herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/311.

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Rheumatoid arthritis (RA), the most common autoimmune disease, affects billions of people worldwide. Conventional therapeutics do not provide satisfactory efficacy and even cause severe adverse reactions. Researchers are seeking new approaches for RA management. Toll-like receptor 4 (TLR4) signalling plays a pivotal role in the pathogenesis of RA, and has been proposed as a potential therapeutic target for RA. Chinese medicines are believed to be alternative options for conventional RA therapeutics. A herbal formula RL, consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, has

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20

Cai, Xiong. "The anti-arthritic effect and underlying mechanisms of QFGJS, a pharmaceutical preparation from a Chinese herbal formula." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/722.

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21

Sang, Wei. "Siegesbeckia pubescens extract attenuates Pam3CSK4-induced inflammation in RAW 264.7 macrophages through suppressing TLR1 TLR2-mediated NF-κB activation". Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952138.

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22

Li, Ting. "Anti-melanoma effects and mechanism of action of a herbal formula comprising Sophorae flos and Lonicerae Japonicae flos." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/432.

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A herbal formula (SL) comprising edible Sophorae Flos and Lonicerae Japonicae Flos was used to treat melanoma in ancient China. In current Chinese medicine practice, the two ingredient herbs of SL are commonly prescribed by Traditional Chinese medicine (TCM) doctors for treating melanoma. However, there is no modern clinical or experimental evidence about the anti-melanoma actions of this formula. Signal transducer and activator of the transcription (STAT3), which is constitutively activated in melanoma, has been proposed as one of the anti-melanoma targets. Some natural compounds in SL have b

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23

Ho, Chun-sing Johnson, and 何晉陞. "Adjunctive use of a Chinese herbal medicine in the non-surgical mechanical treatment of advanced periodontal disease on smokers: a randomized clinical trial." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37651584.

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24

Wang, Di, and 王迪. "Molecular and biochemical characterization of therapeutic properties of paeoniae-glycyrrhiza decoction, a Chinese herbal preparation, against antipsychotic-associated hyperprolactinemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193412.

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Hyperprolactinemia (hyperPRL) is a highly prevalent adverse side effect in antipsychotic therapy as most antipsychotic drugs are dopamine D2 receptor antagonists. Peony-Glycyrrhiza Decoction (PGD, 芍藥甘草湯) is a classic Chinese herbal formula initially used to treat muscle pain and spasm. Our pilot clinical studies have confirmed the effectiveness of PGD in alleviating antipsychotic-induced hyperPRL in patients with schizophrenia. In the present study, we further examined the effects of PGD, its individual herbal preparations and major compounds in suppressing prolactin (PRL) hyperactivity in in

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25

Cheung, Hiu-yee Zelda, and 張曉宜. "Neuroprotection by a mixture of herbal extracts following axotomy: its effect on the molecular mechanisms ofaxotomized retinal ganglion cell death." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31242984.

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26

Lü, Guanghua. "Chemical identification and quality assessment of Radix Angelicae sinensis (Danggui roots)." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/639.

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27

Patnala, Satya Siva Rama Ranganath Srinivas. "Pharmaceutical analysis and quality of complementary medicines : sceletium and associated products." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1018263.

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There has been an upsurge in the use of Complementary and Alternate Medicines (CAMs) in both developed and developing countries. Although herbal medicines have been in use for many centuries, their quality, safety and efficacy are still of major concern. Many countries are in the process of integrating CAMs into conventional health care systems based on the knowledge and use of traditional medicines. The quality control (QC) of herbal products usually presents a formidable analytical challenge in view of the complexity of the constituents in plant material and the commercial non-availability o

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28

Magcwebeba, Tandeka Unathi. "Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85632.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The present study employed a two-phased approach to investigate the possible mechanisms involved in the chemopreventive properties of rooibos (Aspalathus linearis) and different honeybush species (Cyclopia spp.) in vitro. In the first phase, the effect of unfermented methanol and aqueous herbal tea extracts against the growth parameters (cell viability, proliferation and apoptosis) of normal (CRL 7761); premalignant (HaCaT); and malignant (CRL 7762) skin cells was evaluated and compared to green tea extracts. The predictive pote

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29

Wang, Xiao Suo School of Medical Science UNSW. "Mass spectrometric characterization and analysis of anti-oxidative properties of medicinal herbs." Awarded by:University of New South Wales. School of Medical Science, 2003. http://handle.unsw.edu.au/1959.4/19180.

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The aim of this project was to investigate a range of medicinal herbs which have radical scavenging and antioxidant activities and then apply novel mass spectrometric techniques to investigate and analyse active components responsible for their pharmaceutical actions. A sensitive electron capture negative ionization of gas chromatography-mass spectrometry (ECNI-GC-MS) method was developed to assess hydroxyl radical production, as indicated by 3.4-dihydroxyphenylacetic acid (DOPAC) production, which allows excellent evaluation of hydroxyl radical scavenging and antioxidant activity of a number

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30

Liu, Zhongqiu. "Mechanism of pharmacokinetic interaction between paeoniflorin and sinomenine." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/720.

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31

Guo, Hui. "A study on the anti-inflammatory activity and mechanism of action of herba siegesbeckiae (Xixiancao)." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/533.

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To determine whether the three Siegesbeckia plants can all serve as the origins of HS, we compared their fingerprint chromatograms and inhibitory effects on inflammatory mediators. Chemical analyses showed that the three species have different profiles, although they have common peaks in their fingerprint chromatograms. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) of the common peaks demonstrated that all samples of the three species tend to be species-dependently grouped and separated. Ten components contributing to the species discrimination were identified, of

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32

"Analytical and pharmacokinetic studies of the main chemical ingredients of rhizoma chuanxiong." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074230.

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and senkyunolide A were found as the three major compounds in all herbal samples investigated. In addition, great variations in both total and individual content of each of the ten main components investigated were observed in samples of different origins and those collected from a GAP developing base in the same or different years, suggesting the necessity of a thorough quality control for Rhizoma Chuanxiong.<br>Extraction of the main ingredients from Rhizoma Chuanxiong by supercritical fluid extraction using CO2 was investigated. An appropriate SCFE method for Chuanxiong was developed with t

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33

"Chemical, molecular and pharmacological assessment of saussurea lappa clarke." 2004. http://library.cuhk.edu.hk/record=b6073678.

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Chen Feng.<br>"August 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 166-178).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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"Effects of erigerontis herba, its polyphenol-enriched fraction and erigerontis herba containing herbal formulae on metabolic syndrome: in vitro, ex vivo and in vivo evaluation." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1290695.

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Metabolic syndrome refers to clusters of risk factors (e.g. obesity, hyperlipidemia, insulin resistance, non-alcoholic fatty liver and hypertension) that would lead to development of cardiovascular disease. The prevalence of this disease is high and the therapeutic approaches are insufficient. Potential use of Chinese herbal medicines to target on metabolic syndrome has attracted great attention. Erigerontis Herba (EH) is a Chinese herb that is traditionally used to treat cardiovascular and cerebrovascular diseases. Its effect on diet-induced metabolic syndrome has not been previously investig

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35

"Molecular authentication, intestinal absorption and in vitro metabolic studies of the major active ingredients of Rhizoma chuanxiong." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074231.

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Bi-directional transport studies in SimBioDASRTM and Caco-2 cells were employed to examine the transport profiles of Buph, Ligs and SenA. Apical to basolateral (A-B) transport studies of the tested compounds revealed high intestinal permeability and predicted human absorption of over 98%. Permeability ratio of B-A/A-B of Buph (0.7-1.3) and Ligs (0.8-1.2) indicated that they were transported by passive transcellular and paracellular pathways while the low B-A/A-B ratio of SenA may imply possible involvement of other transport mechanisms. One metabolite (M-1) generated from hydration of Buph was

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36

"A study on a Chinese herbal medicine preparation to modulate post-injury swelling of the limb in-vitro and clinical studies." 2004. http://library.cuhk.edu.hk/record=b6073730.

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by Zhao Xin.<br>"October 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 235-260)<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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37

"A prospective longitudinal observational study on the effectiveness of Chinese herbal medicine in advanced cancer patients." 2010. http://library.cuhk.edu.hk/record=b5894361.

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Wong, Ka Yee.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 177-189).<br>Abstracts in English and Chinese; includes Chinese.<br>Abstract --- p.i<br>摘要 --- p.iii<br>Acknowledgements --- p.v<br>Table of Contents --- p.vii<br>List of Appendices --- p.xi<br>List of Tables --- p.xii<br>List of Figures --- p.xiv<br>Abbreviations --- p.xvi<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- General Introduction --- p.1<br>Chapter 1.2 --- Background to the study --- p.2<br>Chapter 1.2.1 --- Epidemiology of cancer ---

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38

"Molecular authentication of epimedium species and the anti-osteoporosis effect of herba epimedii." 2004. http://library.cuhk.edu.hk/record=b6073725.

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Sun Ye.<br>"November 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 205-225)<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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"Investigation of pharmacological anti-diabetic effect on selected traditional Chinese herbs." 2005. http://library.cuhk.edu.hk/record=b5892567.

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by Lam Fung Chun.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 187-202).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abstract in Chinese --- p.iii<br>Acknowledgements --- p.v<br>Table of Contents --- p.vi<br>List of Abbreviations --- p.xiii<br>List of Tables --- p.xvii<br>List of Figures --- p.xviii<br>Publication --- p.xx<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Epidemiology of Diabetes Mellitus --- p.1<br>Chapter 1.2 --- Definition of Diabetes Mellitus --- p.1<br>Chapter 1.3 --- G

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40

"Antitussive alkaloids of stemona tuberosa." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074093.

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Bioassays of total alkaloids of S. tuberosa samples representing the four types of chemical profiles were conducted on guinea pigs using citric acid aerosol for inducing cough. These results demonstrated their antitussive properties and thus suggested the possibility of other antitussive alkaloids than neotuberostemonine in S. tuberosa. So it became necessary to identify the major components in the samples of S. tuberosa representing the four types of chemical profiles.<br>Bioassays on guinea pigs of the four major components of S. tuberosa demonstrated their antitussive properties. Except a

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"Cardiovascular effects of Rhizoma chuanxiong and its active constituents." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074232.

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In a mouse model of pulmonary thromboembolism induced by a collagen-adrenaline mixture, the SFE extract and ligustilide reduced the paralysis-death ratio, and the anti-thrombotic response of senkyunolide A was more pronounced. The effect of BDPH was not significant. Neither the SFE extract nor the three phthalides prolonged bleeding time in tail-transected mice.<br>In a rat myocardial ischemia-reperfusion model involving coronary artery ligation, 7-day pre-treatment with the SFE extract and ligustilide reduced ventricular arrhythmias in isolated hearts. BDPH and senkyunolide A were without sig

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42

"Biological effects of herbal molecules in ocular neovascularization in vitro and in vivo." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075055.

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Angiogenesis is a process of new blood vessels sprouting from the pre-existing vasculature, and mediated by multiple angiogenic and anti-angiogenic factors. Disturbance of the balance often leads to development of neovascular diseases. Neovascularization affecting the eye is a common cause of visual impairment and even blindness, particularly when corneal or choroidal neovascularization (NV) is involved. While there are effective treatment modes for ocular neovascularization, they are expensive and only inhibit disease progress. Since herbal medicine has been applied for anti-angiogenesis and

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"The neuroprotective effect of Tianma-Gouteng formula water extract against cerebral ischemia in vivo and in vitro." 2013. http://library.cuhk.edu.hk/record=b5884519.

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Xian, Jiawen.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 201-230).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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"Antidepressant-like effects of total glycosides of peony and its possible mechanisms." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074989.

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Finally, the neuroprotective effects of TGP against corticosterone-induced neurotoxicity in rat pheochromocytoma (PC12) cells, an in vitro experimental model of depression were studied. The results showed TGP treatment dose-dependently protected the cells against corticosterone-induced toxicity. The cytoprotection afforded by TGP treatment was shown to be associated with an enhanced antioxidant activity, and increased expressions of neurotrophins including brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3.<br>Secondly, the antidepressant-like effect of TGP was evaluated

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Chang, Ya Chun, and 張雅淳. "The Therapeutic Effect of Herbal Formula AR-1 on Allergic Rhinitis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/41492979955822520192.

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碩士<br>長庚大學<br>傳統中國醫學研究所<br>97<br>In order to evaluate the therapeutic effect of herbal formula AR-1 on allergic rhinitis, we conducted a randomized double-blind, placebo -controlled clinical trial in allergic rhinitis patients from 18-45 years old in the clinic of Traditional Chinese Medicine at Chang Gung Memorial Hospital, Taoyuan Branch. Following the confirmed diagnosis by otorhinolaryngologists, the trial participants were randomized to take either AR-1(formula of Long Dan Xie Gan Tang and Zhi Bai Di Huang Wan) or placebo for 4 weeks. Before and after every visit, the Rhinoconjunctivitis

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Weng, Yao-Lin. "Herbal supplements and retirement facility residents : factors that predict usage." Thesis, 2000. http://hdl.handle.net/1957/26566.

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The prevalence of herbal supplement use by the elderly and factors that influence regular versus occasional use were investigated in a group of independent residents of a continuing care retirement community in Salem, Oregon. A nine-page questionnaire was delivered to 402 residents of Capital Manor; 318 questionnaires were usable (84% response rate). The majority of respondents were female (68%) and Caucasian (88%) with an age range of 65 to 100 (average 82.2 years). Twenty percent of all respondents (n=65) were herbal supplement users. Sixty-two percent of them were regular users and 39% were

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"Biochemical evaluation of the hypopigmentary effects of selected Chinese medicines and the constituent compounds." 2012. http://library.cuhk.edu.hk/record=b5549421.

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黑色素生成是為了保護皮膚細胞免受紫外光傷害的一個生化過程。在這過程中，黑色素在人類表皮底層的黑色素細胞的黑色素體內產生。該過程可以被基因，荷爾蒙或環境因素所影響。黑色素的製造量是依賴速度限制酶酪氨酸酶的活性，黑色素體的數量和大小，黑色素體通過黑色素細胞的偽足傳送致角質細胞的速度及黑色素體在角質細胞內的分佈。這些細胞過程會受皮膚顏色或紫外光曝光量的變化而影響。當黑色素的產生超過黑色素的降解，黑色素沉著毛病便出現。根據不同的皮膚類型，年齡組別及累積紫外光曝光程度而引發雀斑或黃褐斑的形成。很多治療方法市面上能夠提供，它們包括人工合成化粧品，激光，整容手術等。這些治療方法通常會產生副作用及蘊藏高風險。因此從天然物質裏尋找治療藥物便成了美容學的一個新的研究方向。在這研究裏，十種草本植物就從自古以來用作治療黑色素沉著毛病的傅統中藥中被挑選出來。那些草本植物被四種擁有不同極性的溶劑提取。小鼠黑色素細胞被用以篩選提取物的降黑色素能力。結果發現當歸的正己烷及二氯甲烷的提取物有正面效用。當歸的化學成份4-乙基間苯二酚、4-乙基苯酚及1-十四烷醇也能降低小鼠黑色素細胞的黑色素量。數種生化技術繼而被應用作研究有效化學物的藥理。他們包括西方墨點法、環磷酸腺苷測試、蛋白激酶A活性測試及酪氨酸酶活性測試。<br>Melanogenesis is a biochemical process designated

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"Development and in-vitro evaluation of peroral and buccoadhesive formulations for biologically active crude oil extracted from Ligusticum chuanxiong, a traditional Chinese medicine." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074235.

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differential scanning calorimetric profile and the generation of much less intense and broader peaks in the powder X-ray diffraction pattern compared to beta-CD. FTIR analysis revealed significant physical interactions between CX oil and beta-CD in the granules, possibly due to complexation. Results from phase solubility measurements and proton nuclear magnetic resonance ( 1H-NMR) analysis of pure 3-butylidenephthalide (3-BDPH), a representative CX component, lend some support for the formation of a 1:1 stoichiometric inclusion complex between 3-BDPH and beta-CD.<br>Rhizoma chuanxiong (CX), th

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49

"Chemical, pharmacological and intestinal absorption studies of stemona alkaloids from radix stemonae." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074118.

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Finally, intestinal absorption of compounds A and H were also investigated by Caco-2 monolayer cell model. These results demonstrated, for the first time, that these stemona alkaloids were well absorbed in a gastrointestinal cell culture model. Furthermore, compound A was demonstrated to have a marked preference in the basolateral to apical transport direction, and such efflux (basolateral to apical) transport was inhibited by both verapamil and cyclosporine A, P-glycoprotein (P-gp) inhibitors, but not by probenecid and MK371, multidrug resistant-associated protein (MRP) inhibitors. The result

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50

"Study of anti-cancer effect of a Trichosanthes sp. extract." 2005. http://library.cuhk.edu.hk/record=b5892352.

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Tang Sze-Wan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 104-118).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abstract (Chinese) --- p.iii<br>Acknownledgement --- p.iv<br>List of Abbreviations --- p.v<br>List of Tables --- p.vii<br>List of Figures --- p.viii<br>Table of Contents --- p.xi<br>Chapter Chapter 1 - --- Introduction<br>Chapter 1.1 --- Trichosanthes spp --- p.1<br>Chapter 1.1.1 --- Use of Trichosanthes --- p.2<br>Chapter 1.1.2 --- Trichosanthin --- p.2<br>Chapter 1.1.3 --- Karasurin --- p.5<br

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