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Cohen, Susan M., Mary Ellen Rousseau, and Elizabeth H. Robinson. "Therapeutic Use of Selected Herbs." Holistic Nursing Practice 14, no. 3 (April 2000): 59–68. http://dx.doi.org/10.1097/00004650-200004000-00010.
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Walker, Ann F. "Herbs of choice: The therapeutic use of phytomedicinals." Trends in Pharmacological Sciences 16, no. 2 (February 1995): 76–77. http://dx.doi.org/10.1016/s0165-6147(00)88982-8.
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Szapary, Philippe O. "Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals." Annals of Internal Medicine 132, no. 12 (June 20, 2000): 1012. http://dx.doi.org/10.7326/0003-4819-132-12-200006200-00040.
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Bidlack, Wayne R. "Tyler’s Herbs of Choice: The Therapeutic Use of Phytochemicals." Journal of the American College of Nutrition 20, no. 3 (June 2001): 265–66. http://dx.doi.org/10.1080/07315724.2001.10719043.
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Korabelnikova, E. A., and Al B. Danilov. "Use of drugs of medicinal herbs for insomnia treatment." Medical alphabet 2, no. 19 (November 26, 2019): 11–18. http://dx.doi.org/10.33667/2078-5631-2019-2-19(394)-11-18.
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Therapy with medicinal herbs in the complex of therapeutic actions for insomnia occupies a special place. The main advantage of phytotherapy of sleep disorders is their high therapeutic efficacy in the absence of side effects, except in cases of individual sensitivity to individual components of the drug. Unlike synthetic drugs, drugs, which are based on vegetable raw materials, have a rapid effect on the extracellular and intracellular metabolic processes. Therefore, the therapeutic effect of medicinal plants is persistent and prolonged. The method of phytotherapy is an alternative and highly effective method of treatment of insomnia, and it should not reject, but significantly complement other methods of modern medicine.
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Ogzewalla, C. Dwayne. "New Publication: Herbs of Choice: The Therapeutic Use of Phytomedicinals." Journal of Pharmacy Technology 11, no. 5 (September 1995): 197–98. http://dx.doi.org/10.1177/875512259501100504.
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Santos-Neto, Leopoldo Luiz dos, Maria Alice de Vilhena Toledo, Patrícia Medeiros-Souza, and Gustavo Almeida de Souza. "The Use of Herbal Medicine in Alzheimer's Disease—A Systematic Review." Evidence-Based Complementary and Alternative Medicine 3, no. 4 (2006): 441–45. http://dx.doi.org/10.1093/ecam/nel071.
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The treatments of choice in Alzheimer's disease (AD) are cholinesterase inhibitors and NMDA-receptor antagonists, although doubts remain about the therapeutic effectiveness of these drugs. Herbal medicine products have been used in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) but with various responses. The objective of this article was to review evidences from controlled studies in order to determine whether herbs can be useful in the treatment of cognitive disorders in the elderly. Randomized controlled studies assessing AD in individuals older than 65 years were identified through searches of MEDLINE, LILACS, Cochrane Library, dissertation Abstract (USA), ADEAR (Alzheimer's Disease Clinical Trials Database), National Research Register, Current Controlled trials, Centerwatch Trials Database and PsychINFO Journal Articles. The search combined the terms Alzheimer disease, dementia, cognition disorders, Herbal, Phytotherapy. The crossover results were evaluated by the Jadad's measurement scale. The systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD:Melissa officinalis,Salvia officinalisand Yi-Gan San and BDW (Ba Wei Di Huang Wan).Ginkgo bilobawas identified in a meta-analysis study. All five herbs are useful for cognitive impairment of AD.M. officinalisand Yi-Gan San are also useful in agitation, for they have sedative effects. These herbs and formulations have demonstrated good therapeutic effectiveness but these results need to be compared with those of traditional drugs. Further large multicenter studies should be conducted in order to test the cost-effectiveness of these herbs for AD and the impact in the control of cognitive deterioration.
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Lee, Gihyun, and Hyunsu Bae. "Therapeutic Effects of Phytochemicals and Medicinal Herbs on Depression." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/6596241.
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Background. Depression is a recurrent, common, and potentially life-threatening psychiatric disease related to multiple assignable causes. Although conventional antidepressant therapy can help relieve symptoms of depression and prevent relapse of the illness, complementary therapies are required due to disadvantage of the current therapy such as adverse effects. Moreover, a number of studies have researched adjunctive therapeutic approaches to improve outcomes for depression patients. Purpose. One potential complementary method with conventional antidepressants involves the use of medicinal herbs and phytochemicals that provide therapeutic benefits. Studies have revealed beneficial effects of medical herbs and phytochemicals on depression and their central nervous system mechanism. Here, we summarize the current knowledge of the therapeutic benefits of phytochemicals and medicinal herbs against depression and describe their detailed mechanisms. Sections. There are two sections, phytochemicals against depression and medical herbs against depression, in this review. Conclusion. Use of phytomedicine may be an alternative option for the treatment of depression in case conventional drugs are not applicable due to their side effects, low effectiveness, or inaccessibility. However, the efficacy and safety of these phytomedicine treatments for depression have to be supported by clinical studies.
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Perumpail, Brandon, Andrew Li, Umair Iqbal, Sandy Sallam, Neha Shah, Waiyee Kwong, George Cholankeril, Donghee Kim, and Aijaz Ahmed. "Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD." Diseases 6, no. 3 (September 10, 2018): 80. http://dx.doi.org/10.3390/diseases6030080.
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Our aim is to review the efficacy of various herbs and supplements as a possible therapeutic option in the treatment and/or prevention of nonalcoholic fatty liver disease (NAFLD). We performed a systematic review of medical literature using the PubMed Database by searching the chemical names of many common herbs and supplements with “AND (NAFLD or NASH)”. Studies and medical literature that discussed the roles and usage of herbs and supplements in NAFLD and nonalcoholic steatohepatitis (NASH) from inception until 20 June 2018 were reviewed. Many studies have claimed that the use of various herbs and supplements may improve disease endpoints and outcomes related to NAFLD and/or NASH. Improvement in liver function tests were noted. Amelioration or reduction of lobular inflammation, hepatic steatosis, and fibrosis were also noted. However, well-designed studies demonstrating improved clinical outcomes are lacking. Furthermore, experts remain concerned about the lack of regulation of herbs/supplements and the need for further research on potential adverse effects and herb–drug interactions. In conclusion, preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory, anti-apoptotic, and anti-adipogenic properties that may help curtail the progression of NAFLD/NASH. Clinical trials testing the safety and efficacy must be completed before widespread can be recommended.
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Liu, Wei, Binbin Yang, Lu Yang, Jasmine Kaur, Calvin Jessop, Rushdi Fadhil, David Good, et al. "Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers." Evidence-Based Complementary and Alternative Medicine 2019 (September 15, 2019): 1–10. http://dx.doi.org/10.1155/2019/6057837.
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Effective cancer therapy is one of the biggest global challenges. Conventional cancer therapies have been at the forefront of combating cancers, but more evidence showed considerable side effects, limiting their use. There are various new therapies in development, but combined approaches for treating cancer are much expected. Natural herbs had been traditionally in use for cancer therapy in most parts of the world. In this review, we have examined ten commonly used Chinese herbs that have, for centuries, shown effectiveness in treating cancers. They demonstrated the abilities to promote the apoptosis of cancer cells, inhibit their metastasis, activate the patient’s anticancer immunity, and synergistically increase the efficacy of conventional chemotherapy and radiation therapy when used in combination. Clinical experiences had proved that these herbs and their bioactive compounds were effective against a plethora of cancers through a variety of mechanisms, effectively improving patients’ quality of life without significant side effects. These advantages indicate that there are huge potentials in the development of Chinese herbs into cancer medicine as part of a promising, holistic cancer treatment modality.
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Ward, Adam. "Book Review: Tyler—s Herbs of Choice: The Therapeutic Use of Phytomedicinals." Acupuncture in Medicine 18, no. 1 (June 2000): 84–87. http://dx.doi.org/10.1136/aim.18.1.84-b.
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Asamoah-Gyadu, J. Kwabena. "Therapeutic Strategies in African Religions: Health, Herbal Medicines and Indigenous Christian Spirituality." Studies in World Christianity 20, no. 1 (April 2014): 70–90. http://dx.doi.org/10.3366/swc.2014.0072.
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The use of herbs has been the main means of curing diseases in traditional Africa and this continued through the colonial period to present times. Widely held traditional views that interpreted certain diseases as caused by supernatural agents meant that, although some ailments could be naturally caused, in most cases, shrine priests and diviners were needed to dispense herbal preparations for clients. Christian missionaries mostly – though by no means all – denounced herbal medicines as evil, looking on them as pagan because of the close relationship between herbs and agents of local divinities. At the emergence of the African independent church movement at the beginning of the twentieth century, herbal medicines acquired a sacramental value, and today they are obtained from churches and local prophets as therapeutic substances infused with spiritual power for healing. The sacramental interpretation of herbs has been extended to those obtained from prayer places and grottoes under the supervision of historic mission denominations, a phenomenon that has virtually transformed the image of herbs and herbal medicines in African therapeutic systems.
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Ade-Ademilua, Omobolanle E. "Tyler's Herbs of Choice—The Therapeutic Use of Phytomedicinalsby Dennis V. C. Awang." Journal of Herbs, Spices & Medicinal Plants 15, no. 3 (December 10, 2009): 291. http://dx.doi.org/10.1080/10496470903379035.
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Vilímek, Vítězslav. "Denominations of Herbs in Těšín Silesia motivated by their therapeutic effects." Slavic Almanac, no. 3-4 (2020): 270–88. http://dx.doi.org/10.31168/2073-5731.2020.3-4.3.03.
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This study focuses on the names of medicinal plants which are used in the linguistic area of Těšín Silesia and which have been derived from their eff ects known in folk human and veterinary medicine. The etymol-ogy of the names of these plants was transparent to the average speaker of the language and acted as a clear guide on how to use them. It is therefore a suitable source of ethnolinguistic knowledge. We identify four typical types of motivation: the organ or part of body for which the plant is used; the disease against which the plant is used; the eff ect; the person or animal for whose treatment the plant is used. Each type is documented using specifi c examples and aided by analyses of the origin of the name of the plant and its therapeutic use as it is known in Těšín Silesia. In interesting cases, comparison with contemporary Czech and other Slavic languages is also carried out.
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Soyata, Amelia, Aliya Nur Hasanah, and Taofik Rusdiana. "Interaction of Warfarin with Herbs Based on Pharmacokinetic and Pharmacodynamic Parameters." Indonesian Journal of Pharmaceutics 2, no. 2 (June 5, 2020): 69. http://dx.doi.org/10.24198/idjp.v2i2.27289.
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Warfarin is an oral anticoagulant that has been widely used and has strong efficacy, but the use of warfarin is still a concern because of its narrow therapeutic index which cause interactions when co-administration with drugs, herbs or food. This interaction can affect the pharmacokinetics and pharmacodynamics of warfarin and the most fatal effect from warfarin interactions is bleeding. In this review article data on warfarin-herbs interactions were collected based on pharmacokinetic parameters (AUC0-∞, Cmax, T1/2, Cl/F, and V/F), while pharmacodynamic parameters (International normalized ratio (INR), platelet aggregation, AUC INR and Protombine Time). As a result some herbs had significant interactions with warfarin. Herbs that affect warfarin pharmacokinetic were Danshen gegen, echinacea, St. John's wort and caffeine and herbs that affect pharmacodynamic were policosanol, Ginkgo biloba, cranberry, St. John's wort, ginseng, pomegranate, Psidium guajava and curcumin, so co-administration warfarin with herbs need to be considered.Keywords: Warfarin, Interactions, Herbs, Pharmacokinetics, Pharmacodynamics
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Djunaedi, Mochamad, and Syed Azhar Syed Sulaiman. "THE PHARMACIST’S ASSESSMENT ON PATIENTS WHO CONSUME SUPPLEMENTS AND HERBAL WHILE UNDERGOING WARFARIN THERAPY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 13 (April 26, 2018): 49. http://dx.doi.org/10.22159/ajpcr.2018.v11s1.26566.
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Objective: The supplements and herbal medicines used should be monitored in a patient taking warfarin, to achieve the goal of warfarin anticoagulation. This study aims to evaluate the impacts of the supplement and the herbs used on the performance of anticoagulation.Methods: There were 214 eligible patients for having CHADS2 score >2 registered at warfarin-medication therapy adherence clinic coordinated by Cardiac Hospitals in Malaysia in 2012 included for this study. They have been assessed using a trained pharmacist regarding the safety and efficacy of warfarin as per guideline. Results: Supplements and herbs are commonly used by the patient (61.2%) who is taking warfarin. Some patients (23%) have decided not to use or stop using it after being consulted by the pharmacist. Some are even starting to use it (37%). Effects of supplements and herbal medicines were found to decrease in the International normalized ratio (INR) reading as 33%, increasing in 37% the INR reading. Further, pharmacist action is to do a dose adjustment to reach INR in the therapeutic range 2.0–3.0. Supplements consumed as categorized as phytomedicine-containing herbs, such as Omega3 and glucosamine. Whereas herbs used as beetle leaves and the product of extracted herbs, for example, Gingko biloba, Cordyceps, etc. Conclusion: Monitoring by pharmacist is needed to achieve the goal of warfarin as well as to minimize the INR out of therapeutic. The use of herbal and supplement is found to be a factor contributes to the performance of anticoagulation control which has been successfully achieved 71.2%.
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Kelber, Olaf, Rudolf Bauer, and Wolfgang Kubelka. "Phytotherapy in Functional Gastrointestinal Disorders." Digestive Diseases 35, Suppl. 1 (2017): 36–42. http://dx.doi.org/10.1159/000485489.
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Background: Phytotherapy is an important therapeutic option in functional gastrointestinal diseases (FGID). It has a large tradition, with different approaches in different regions of the world, some of which have made their way into modern evidence-based medicine (EBM). Summary: Taking into account the number of herbs in use, and also the cumulated scientific evidence on them, FGID are possibly the most important indication in phytotherapy. This does not only apply for European phytotherapy, but also for other regions, such as Asia. Within European phytotherapy, herbs active in FGID are usually classified according to their main active constituents and their activities. Typically, the herbs used in FGID are grouped into amara, aromatica, amara aromatica combining both properties, herbs stimulating gastric secretion, herbs containing spasmolytic and carminative essential oils or spasmolytic alkaloids, mucilaginosa soothing the mucosa, and flavonoid containing drugs with anti-inflammatory properties. In phytotherapy, different plants are frequently combined to maximize effectiveness and specificity of action. Very potent combination products can be developed when the mechanisms of action of the combination partners are complementary. This approach can be demonstrated by the example of STW 5. For this herbal combination product, therapeutic efficacy in FGID has been clinically proven according to the highest standards of EBM. This example also underlines that modern rational phytotherapy is definitely part of modern EBM. Key Messages: FGID is one of the most important indications in phytotherapy and rationally combined herbal preparations are established evidence-based therapeutic options.
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Ge, Beikang, Zhen Zhang, and Zhong Zuo. "Updates on the Clinical Evidenced Herb-Warfarin Interactions." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–18. http://dx.doi.org/10.1155/2014/957362.
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Increasing and inadvertent use of herbs makes herb-drug interactions a focus of research. Concomitant use of warfarin, a highly efficacious oral anticoagulant, and herbs causes major safety concerns due to the narrow therapeutic window of warfarin. This paper presents an update overview of clinical findings regarding herb-warfarin interaction, highlighting clinical outcomes, severity of documented interactions, and quality of clinical evidence. Among thirty-eight herbs, Cannabis, Chamomile, Cranberry, Garlic, Ginkgo, Grapefruit, Lycium, Red clover, and St. John’s wort were evaluated to have major severity interaction with warfarin. Herbs were also classified on account of the likelihood of their supporting evidences for interaction. Four herbs were considered ashighly probableto interact with warfarin (level I), three were estimated asprobable(level II), and ten and twenty-one werepossible(level III) anddoubtful(level IV), respectively. The general mechanism of herb-warfarin interaction almost remains unknown, yet several pharmacokinetic and pharmacodynamic factors were estimated to influence the effectiveness of warfarin. Based on limited literature and information reported, we identified corresponding mechanisms of interactions for a small amount of “interacting herbs.” In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes.
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Fathinezhad, Zohre, Robert D. E. Sewell, Zahra Lorigooini, and Mahmoud Rafieian-Kopaei. "Depression and Treatment with Effective Herbs." Current Pharmaceutical Design 25, no. 6 (June 12, 2019): 738–45. http://dx.doi.org/10.2174/1381612825666190402105803.
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Depression is a common psychiatric disease and one of the main causes of disability worldwide. In spite of certain developments in this field, chemical and synthetic drugs used for the treatment of depression disrupt the treatment process due to numerous side effects and high cost. Today, the goal of using a potential method for treating depression involves the use of medicinal and phytochemical plants, which have many therapeutic benefits. Studies have shown that medicinal plants affect the nervous system and exert antidepressant effects in various ways, including synaptic regulation of serotonin, noradrenaline and dopamine, and inflammatory mediators. In this study, depression as well as the factors and mechanisms involved in its development are first addressed, and then medicinal plants effective in the treatment of depression along with their mechanisms of actions are reported.
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Jiang, T. Alan. "Health Benefits of Culinary Herbs and Spices." Journal of AOAC INTERNATIONAL 102, no. 2 (March 1, 2019): 395–411. http://dx.doi.org/10.5740/jaoacint.18-0418.
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Abstract Spices and herbs have been in use for centuries both for culinary and medicinal purposes. Spices not only enhance the flavor, aroma, and color of foodand beverages, but they can also protect from acuteand chronic diseases. More Americans are considering the use of spices and herbs for medicinal and therapeutic/remedy use, especially for various chronicconditions. There is now ample evidence that spicesand herbs possess antioxidant, anti-inflammatory, antitumorigenic, anticarcinogenic, and glucose- and cholesterol-lowering activities as well as properties that affect cognition and mood. Research over the past decade has reported on the diverse range of health properties that they possess via their bioactive constituents, including sulfur-containing compounds, tannins, alkaloids, phenolic diterpenes, andvitamins, especially flavonoids and polyphenols. Spices and herbs such as clove, rosemary, sage, oregano, and cinnamon are excellent sources of antioxidants with their high content of phenolic compounds. It is evident that frequent consumption of spicy foods was also linked to a lower risk of death from cancer and ischemic heart and respiratory system diseases. However, the actual role of spicesand herbs in the maintenance of health, specifically with regards to protecting against the development of chronic, noncommunicable diseases, is currently unclear.This review highlights potential health benefits ofcommonly used spices and herbs such as chili pepper, cinnamon, ginger, blackpepper, turmeric, fenugreek, rosemary, and garlic.
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Lin, Sheng-Chieh, Li-Shian Shi, and Yi-Ling Ye. "Advanced Molecular Knowledge of Therapeutic Drugs and Natural Products Focusing on Inflammatory Cytokines in Asthma." Cells 8, no. 7 (July 5, 2019): 685. http://dx.doi.org/10.3390/cells8070685.
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Asthma is a common respiratory disease worldwide. Cytokines play a crucial role in the immune system and the inflammatory response to asthma. Abnormal cytokine expression may lead to the development of asthma, which may contribute to pathologies of this disease. As cytokines exhibit pleiotropy and redundancy characteristics, we summarized them according to their biologic activity in asthma development. We classified cytokines in three stages as follows: Group 1 cytokines for the epithelial environment stage, Group 2 cytokines for the Th2 polarization stage, and Group 3 cytokines for the tissue damage stage. The recent cytokine-targeting therapy for clinical use (anti-cytokine antibody/anti-cytokine receptor antibody) and traditional medicinal herbs (pure compounds, single herb, or natural formula) have been discussed in this review. Studies of the Group 2 anti-cytokine/anti-cytokine receptor therapies are more prominent than the studies of the other two groups. Anti-cytokine antibodies/anti-cytokine receptor antibodies for clinical use can be applied for patients who did not respond to standard treatments. For traditional medicinal herbs, anti-asthmatic bioactive compounds derived from medicinal herbs can be divided into five classes: alkaloids, flavonoids, glycosides, polyphenols, and terpenoids. However, the exact pathways targeted by these natural compounds need to be clarified. Using relevant knowledge to develop more comprehensive strategies may provide appropriate treatment for patients with asthma in the future.
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Sparreboom, Alex, Michael C. Cox, Milin R. Acharya, and William D. Figg. "Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents." Journal of Clinical Oncology 22, no. 12 (June 15, 2004): 2489–503. http://dx.doi.org/10.1200/jco.2004.08.182.
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Purpose Interest in the use of herbal products has grown dramatically in the Western world. Recent estimates suggest an overall prevalence for herbal preparation use of 13% to 63% among cancer patients. With the narrow therapeutic range associated with most anticancer drugs, there is an increasing need for understanding possible adverse drug interactions in medical oncology. Methods In this article, a literature overview is provided of known or suspected interactions of the 15 best-selling herbs in the United States with conventional allopathic therapies for cancer. Results Herbs with the potential to significantly modulate the activity of drug-metabolizing enzymes (notably cytochrome P450 isozymes) and/or the drug transporter P-glycoprotein include garlic (Allium sativum), ginkgo (Ginkgo biloba), echinacea (Echinacea purpurea), ginseng (Panax ginseng), St John's wort (Hypericum perforatum), and kava (Piper methysticum). All of these products participate in potential pharmacokinetic interactions with anticancer drugs. Conclusion It is suggested that health care professionals and consumers should be aware of the potential for adverse interactions with these herbs, question their patients on their use of them, especially among patients whose disease is not responding to treatments as expected, and urge patients to avoid herbs that could confound their cancer care.
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Sharma, Hari M. "Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. James E. Robbers , Varro E. Tyler." Quarterly Review of Biology 74, no. 3 (September 1999): 370. http://dx.doi.org/10.1086/393241.
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Karole, Sarita, Sarika Shrivastava, Shefali Thomas, Bhawana Soni, Shifa Khan, Julekha Dubey, Shashi P. Dubey, Nushrat Khan, and Deepak Kumar Jain. "Polyherbal Formulation Concept for Synergic Action: A Review." Journal of Drug Delivery and Therapeutics 9, no. 1-s (February 15, 2019): 453–66. http://dx.doi.org/10.22270/jddt.v9i1-s.2339.
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Formulations restrain 2 or more than 2 herbs are called polyherbal formulation. Drug formulation in Ayurveda is based on 2 principles: Use as a single drug and use of more than one drug. The last is known as polyherbal formulation. The idea of polyherbalism is peculiar to Ayurveda even though it is tricky to explain in term of modern parameters. The Ayurvedic literature Sarangdhar Samhita tinted the idea of polyherbalism to attain greater therapeutic efficacy. Polyherbal formulation has been used all around the earth due to its medicinal and therapeutic application. It has also recognized as polyherbal therapy or herb-herb combination. The active phytochemical constituents of individual plants are inadequate to attain the desirable therapeutic effects. When polyherbal and herbo-mineral formulations combining the multiple herbs in a meticulous ratio, it will give an enhanced therapeutic effect and decrease the toxicity. The active constituents used from individual plant are inadequate to provide attractive pharmacological action. There are evidences that crude plant extracts often have greater potency rather than isolated constituents. In traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. Due to synergism, polyherbalism confers some benefits which are not accessible in single herbal formulations. Polyherbal formulations express high effectiveness in numerous diseases with safe high dose. Based on the nature of the interaction, there are 2 mechanisms on how synergism acts (i.e., pharmacodynamics and pharmacokinetic). In words of pharmacokinetic synergism, the capacity of herb to ease the absorption, distribution, metabolism and elimination of the other herbs is focused. Pharmacodynamics synergism on the other hand, studies the synergistic effect when active constituents with similar therapeutic activity are targeted by diverse mechanism of action. The present review encompasses all the significant features of polyherbal formulation.
Keywords: Polyherbal formulation, Ayurveda, Active constituents, Pharmacodynamics, pharmacokinetic
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Fu, Li-Min, and Ju-Tzu Li. "A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–8. http://dx.doi.org/10.1093/ecam/nep136.
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The objectives here are to provide a systematic review of the current evidence concerning the use of Chinese herbs in the treatment of Alzheimer's disease (AD) and to understand their mechanisms of action with respect to the pathophysiology of the disease. AD, characterized microscopically by deposition of amyloid plaques and formation of neurofibrillary tangles in the brain, has become the most common cause of senile dementia. The limitations of western medications have led us to explore herbal medicine. In particular, many Chinese herbs have demonstrated some interesting therapeutic properties. The following databases were searched from their inception: MEDLINE (PUBMED), ALT HEALTH WATCH (EBSCO), CINAH and Cochrane Central. Only single Chinese herbs are included. Two reviewers independently extracted the data and performed quality assessment. The quality assessment of a clinical trial is based on theJadadcriteria. Seven Chinese herbs and six randomized controlled clinical trials were identified under the predefined criteria.Ginkgo biloba, Huperzine A (Lycopodium serratum) and Ginseng have been assessed for their clinical efficacy with limited favorable evidence. No serious adverse events were reported. Chinese herbs show promise in the treatment of AD in terms of their cognitive benefits and more importantly, their mechanisms of action that deal with the fundamental pathophysiology of the disease. However, the current evidence in support of their use is inconclusive or inadequate. Future research should place emphasis on herbs that can treat the root of the disease.
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Milić, Nataša, Nataša Milošević, Svetlana Goločorbin Kon, Teodora Božić, Ludovico Abenavoli, and Frances Borrelli. "Warfarin Interactions with Medicinal Herbs." Natural Product Communications 9, no. 8 (August 2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900835.
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Recognition of the adverse effects of medicinal herbs is not routine and the reports on such effects are even less frequent in clinical practice. Potential herb-drug interactions are of a major safety concern, especially for drugs with narrow therapeutic indices like warfarin, which can lead to severe adverse reactions that are sometimes life-threatening. The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. The references on the analyzed literature have been investigated in order to collect the existing data. The case reports with severe adverse effects such as spontaneous postoperative bleeding, formation of hematomas, hematemesis, melena, thrombosis, subarachnoid hemorrhage and/or subdural hematomas after concomitant use of warfarin and the medicinal herbs: Panax ginseng, Hypericum perforatum, Salvia milthiorizza, Gingko biloba, Serenoa repens, Angelica sinensis, Vaccinium species, Allium sativum, Zingiber officinale, Tanacetum parthenium, Lucium barbarum, Matricaria chamomilla, Boswellia serrata and Camellia sinensis have been estimated. Some of the interactions between warfarin and medicinal herbs have been well assessed proving that they are closely-dependent. The interactions between warfarin and medicinal herbs, not generally reported in previous reviews, are presented in our review. The health professionals who are involved in treating the patients are expected to be fully informed about the interactions between warfarin and medicinal herbs in order to minimize the health risks of the patients.
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Zhang, Shaofan, Li Shi, Dan Mao, Weijun Peng, Chenxia Sheng, Chenchen Ding, Fengxia Lin, Caiyun Lei, and Sifang Zhang. "Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/6180810.
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Objective. To systematically review the effect of invigorating Pi and detoxification (Jianpi Jiedu, (JPJD)) herbs in advanced colorectal cancer (CRC) patients receiving chemotherapy. Methods. Three English and four Chinese databases were searched. Literature was screened by EndNote X7 and data were analyzed by RevMan 5.2. Results. This review comprised 12 randomized clinical studies of 701 patients. The results showed that JPJD herbs improved the therapeutic effect on Chinese medicine symptoms [risk ratio (RR) = 1.59; 95% confidence interval (CI): 1.35~1.88] and Karnofsky performance score [RR = 2.07; 95% CI: 1.52~2.82] for advanced CRC patients receiving chemotherapy, lowered the Chinese medicine symptoms’ score [weighted mean difference = −2.44; 95% CI: −3.23~−1.64], reduced the incidence of nausea and vomiting [RR = 0.23; 95% CI: 0.11~0.49], improved platelet at toxicity grades III-IV [odds ratio = 0.29; 95% CI: 0.12~0.74] and I–IV [RR = 0.65; 95% CI: 0.51~0.82], and improved white blood cell at toxicity grades III-IV [RR = 0.37; 95% CI: 0.23~0.58] and I–IV [RR = 0.69; 95% CI: 0.60~0.79]. However, the results showed no significant effect on tumor response. Conclusion. JPJD herbs can improve quality of life, relieve symptoms, and reduce adverse events of advanced CRC patients receiving chemotherapy.
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Ahmed, Salahuddin, Jeremy Anuntiyo, Charles J. Malemud, and Tariq M. Haqqi. "Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis: A Review." Evidence-Based Complementary and Alternative Medicine 2, no. 3 (2005): 301–8. http://dx.doi.org/10.1093/ecam/neh117.
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Osteoarthritis (OA) of the knee and hip is a debilitating disease affecting more women than men and the risk of developing OA increases precipitously with aging. Rheumatoid arthritis (RA), the most common form of inflammatory joint diseases, is a disease of unknown etiology and affects ∼1% of the population worldwide, and unlike OA, generally involves many joints because of the systemic nature of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first drugs of choice for the symptomatic treatment of both OA and RA. Because of the risks associated with the use of NSAIDs and other limitations, the use of alternative therapies, such as acupuncture and medicinal herbs, is on the rise and according to reports ∼60–90% of dissatisfied arthritis patients are likely to seek the option of complementary and alternative medicine (CAM). This paper reviews the efficacy of some of the common herbs that have a history of human use and their anti-inflammatory or antiarthritic properties have been evaluated in animal models of inflammatory arthritis, in studies employing well defined and widely acceptedin vitromodels that use human chondrocytes/cartilage explants or in clinical trials. Available data suggests that the extracts of most of these herbs or compounds derived from them may provide a safe and effective adjunctive therapeutic approach for the treatment of OA and RA. This, in turn, argues for trials to establish efficacy and optimum dosage of these compounds for treating human inflammatory and degenerative joint diseases.
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Tyler, Varro E. "Herbal Remedies." Journal of Pharmacy Technology 11, no. 5 (September 1995): 214–20. http://dx.doi.org/10.1177/875512259501100510.
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Objective: To provide an overview of basic information required by pharmacists to advise patients on the proper use of selected herbs and phytomedicines (“dietary supplements”) as therapeutic agents. Data Sources: The vast literature on this topic in the English, German, and French languages has been researched by the author over a period of many years. Databases that were used include NAPRALERT and MEDLINE. Study Selection: Articles and books dealing with the current popularity of botanical medicine and with laws and regulations covering so-called dietary supplements, as well as information on selected toxic herbs and a few of the most popular beneficial herbs used for treating common ailments and syndromes. Data Synthesis: Studies suggest that many herbal products currently available are both safe and effective drugs. A few products on the US market are definitely unsafe for human consumption and use. Conclusions: The increasing popularity of botanicals, coupled with regulations that prohibit definitive labeling, requires pharmacists to acquire accurate information based on scientifically and clinically acceptable data to advise patients on their use. Useful remedies for several common ailments and information concerning their safety and usefulness provide a starting point for an understanding of this complex field.
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Fifi, Amanda, Cara Axelrod, Partha Chakraborty, and Miguel Saps. "Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials." Nutrients 10, no. 11 (November 9, 2018): 1715. http://dx.doi.org/10.3390/nu10111715.
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More than fifty percent of all new patient visits to pediatric gastroenterology clinics consult for functional abdominal pain disorders (FAPDs). In 2005, a technical report of the American Academy of Pediatrics and the North American Pediatric Gastroenterology, Hepatology and Nutrition society (NASPGHAN) found limited or inconclusive evidence for most therapeutic interventions for this group of disorders. The report did not include studies on herbs and spices. Since then, there has been an increasing interest in the use of complementary and alternative medicine (CAM) for the treatment of chronic pain disorders in children. About 40% of parents of pediatric gastroenterology patients have utilized CAM. This review evaluated the published literature on the effectiveness of CAM, specifically the use of herbs and spices, for the treatment of FAPDs. We found little evidence for most of the commonly used herbs and spices. Despite its common use, research on the efficacy, safety, and optimal dosage remains limited. There is evidence to suggest the benefit of peppermint oil and STW 5 for the treatment of FAPDs in children. The paucity of data on most therapies underscores the need for large clinical trials to assess their efficacy.
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Kurtaran, Melek, Neriman Sila Koc, Melek Seren Aksun, Tolga Yildirim, Şeref Rahmi Yilmaz, and Yunus Erdem. "Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report." Therapeutic Advances in Drug Safety 12 (January 2021): 204209862110093. http://dx.doi.org/10.1177/20420986211009358.
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Sirolimus is an immunosuppressive drug used to prevent graft rejection. Therapeutic drug monitoring is required as with other immunosuppressive drugs. Previous studies have shown the interactions between sirolimus and drugs that affect the activity of cytochrome P450 3A4 and P-glycoprotein. There is an increasing tendency for the use of herbal remedies in many countries. Medicinal herbs are rich sources of natural bioactive compounds that could interact with drugs. Parsley, Petroselinum crispum, is a food, spice, and also a medicinal herb. We report a case of a renal transplant recipient who had a supratherapeutic blood level of sirolimus due to consuming excessive parsley to highlight a possible herb–drug interaction. This is the first case report describing sirolimus–parsley interaction. Herb–drug interactions are especially important for drugs with a narrow therapeutic window. For this reason, healthcare professionals should question all patients, especially transplant patients, about the use of herbs or herbal products and report interactions. Plain Language Summary Parsley, a commonly consumed food, affects the level of an important drug in a renal transplant recipient: A case report Sirolimus is a drug that suppresses the immune response used to prevent organ rejection in people who have had kidney transplants. In order to reach the optimum balance between therapeutic efficacy and adverse effects, sirolimus blood levels should be closely monitored. Previous studies have shown the interactions between sirolimus and drugs that affect the activities of metabolizing enzymes and transporter proteins. Parsley is a food, spice, and also a medicinal herb. Medicinal herbs are rich sources of natural bioactive compounds that could interact with a prescription drug. We report a case of a renal transplant recipient who had a rise in the blood level of sirolimus due to the ingestion of an excessive amount of parsley to highlight possible herb–drug interaction.
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Szentmihályi, Klára, Zoltán May, Krisztina Süle, and Mária Then. "Mineral element content of some herbs with antiinflammatory effect used in gastrointestinal diseases." Orvosi Hetilap 154, no. 14 (April 2013): 538–43. http://dx.doi.org/10.1556/oh.2013.29578.
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Introduction: In gastrointestinal diseases folk medicine usually recommends herbs and teas with antiinflammatory activities, especially mucilage and bitter agent containing plants. The use of stomatics as adjuvant therapy in medical practice is frequent. Aim: The authors explored the mineral element content of some herbs, because mineral elements may have significant role in the development and treatment of gastrointestinal diseases, and a close connection between the presence or absence of mineral elements and inflammatoric mediators was noted. Methods: The mineral content in Trigonellae foenugraeci semen, Farfarae folium et flos, Taraxaci radix and Cichorii radix and teas prepared from these herbs was determined using inductively coupled plasma optical emission spectrometry. The results were evaluated from nutritional and biomedical points of view. Results:Farfarae folium et flos tea was found to be a rich source of calcium, chromium, manganese and molybdenum. Trigonellae foenugraeci semen, Taraxaci radix and Cichorii radix displayed favourable calcium to magnesium ratio (1–1.5) and they contained other elements (manganese, iron, copper, zinc) which may have significant role in the immune defence system. Conclusion: The beneficial therapeutic effect of the studied herbs may be related to their mineral element content. Orv. Hetil., 2013, 154, 538–543.
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Guven, Hulya, Sule Kalkan, Nil Hocaoglu, Engin Yildiztepe, and Gamze Gokalp. "Evaluation of the knowledge level and usage attitudes of the medical students on the medicinal herbs and herbal products: a project of special study module in the first three years of the school of medicine." International Journal of Basic & Clinical Pharmacology 8, no. 3 (February 23, 2019): 394. http://dx.doi.org/10.18203/2319-2003.ijbcp20190566.
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Background: In this survey, it was aimed to determine the types of medicinal herbs and herbal products, reasons of use and consciousness levels among the medical students in the first three years of the School of Medicine.Methods: A cross-sectional descriptive questionnaire consisting of 50 questions was applied to all the students in the first three years of Dokuz Eylül University School of Medicine between September 1, 2016 and June 1, 2017.Results: The results of 571 participating students were evaluated. Of these students, 301 (52.7%) were females and 270 (47.3%) were males. It was found that 73.4% (n=419) of the students used these products for treatment and mostly consumed linden, sage tea, mint and rosehip. Also, 11.6% of the students had chronic diseases (n=66). It was determined that 69.7% (n=46) of these students having chronic diseases used medicinal herbs and herbal products. Only 12.0% of the students had an opinion about the legal regulations regarding the use of herbs and herbal products in Turkey, while 39.7% of them had no idea, and 48.3% stated that such regulations on this matter were unreasonable. However, 59.7% of the respondents stated that legal regulations were necessary. It was found that the participating students used herbs and herbal products generally for therapeutic purposes without having sufficient knowledge about medicinal herbs; therefore it was necessary to increase their level of consciousness.Conclusions: Medical students neither have adequate medical information about medicinal herbs and herbal products, nor about the regulations on these products. It is crucial to revise the courses in the medical education so that the students would get informed about the regulations as well as potential risks of herbal plants while still in the medical schools.
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Yin, Shu-Yi, Wen-Chi Wei, Feng-Yin Jian, and Ning-Sun Yang. "Therapeutic Applications of Herbal Medicines for Cancer Patients." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/302426.
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Medicinal herbs and their derivative phytocompounds are being increasingly recognized as useful complementary treatments for cancer. A large volume of clinical studies have reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Here, we briefly review some examples of clinical studies that investigated the use of herbal medicines for various cancers and the development of randomized controlled trials (RCTs) in this emerging research area. In addition, we also report recent studies on the biochemical and cellular mechanisms of herbal medicines in specific tumor microenvironments and the potential application of specific phytochemicals in cell-based cancer vaccine systems. This review should provide useful technological support for evidence-based application of herbal medicines in cancer therapy.
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Samuels, Noah. "Herbal remedies and anticoagulant therapy." Thrombosis and Haemostasis 93, no. 01 (2005): 03–07. http://dx.doi.org/10.1160/th04-05-0285.
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SummaryHerbal remedies, considered to be both safe and effective by most consumers, may interact with conventional drugs.Warfarin, a vitamin K antagonist originally derived from the sweet clover plant, has a narrow therapeutic window which can be monitored using prothrombin international normalized ratios (PT-INR). Many herbs can increase the risk for bleeding when combined with warfarin, either by augmenting the anticoagulant effects of the drug (with increased PT-INR levels) or through intrinsic anti-platelet properties (without altering PT-INR levels). The increased risk for bleeding among such patients may be difficult to predict, especially when formulas which contain many herbs are used. Further research into herb-drug interactions is warranted, as are guidelines for the use of herbal remedies by patients on chronic anticoagulation therapy.
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Chouhan, Bhupendra Singh, Surendra Singh Rajput, Ramakant Dwivedi, and AK Singh. "A REVIEW ON AYURVEDA PERSPECTIVE AND THERAPEUTIC CONSIDERATION OF OLIGOZOOSPERMIA." Journal of Drug Delivery and Therapeutics 8, no. 5-s (October 15, 2018): 55–58. http://dx.doi.org/10.22270/jddt.v8i5-s.1939.
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Male infertility is one of the burning problems now a day’s and incidences of this problem increases day by day due to the disturbed pattern of living style. The Oligozoospermia is one of the conditions related to male infertility which associated with low sperm count. Ayurveda the science of Indian medical system described various terms related to male infertility such as; Kshina shukra, Kshina retasa, Alpa retasa and Shukra dosha which resembles conditions associated with oligozoospermia. Ayurveda also described various treatment modalities for the management of oligozoospermia such as use of herbs & formulation, conduction of balanced life style and diet control, etc. This article presented a conclusive review on ayurveda perspective of oligozoospermia and its management.
Keywords: Ayurveda, Male Infertility, Oligozoospermia, Sperm, Vajikarana.
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Manthey, Abby Leigh, Kin Chiu, and Kwok-Fai So. "Demystifying traditional Chinese medicines: Lycium barbarum as a model therapeutic." Traditional Medicine and Modern Medicine 01, no. 01 (March 2018): 15–19. http://dx.doi.org/10.1142/s2575900018300011.
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The practice of Traditional Chinese Medicine (TCM) focuses on holistic treatment of the body. This often includes preparation and application of medicinal herbs, either alone or in combination with other supplements. Lycium barbarum (LB), for example, is a commonly used herbal supplement in many Asian countries, being most well-known for improving kidney, liver, and eye health. It is also one of the most widely scientifically researched TCMs and a large body of literature is available describing its effects on various tissues and organ systems. In this perspective, we briefly expand upon how LB can be used as a model TCM in the systematic study of other herbal medicines, highlighting two of the primary barriers to their use in modern medicine worldwide.
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Ashiya A S Azim and Dhirajsingh Rajput. "Drugs For Ayurvedic Hand Sanitizer And Nasal Spray And Its Method Of Preparation." International Journal of Research in Pharmaceutical Sciences 11, SPL1 (August 4, 2020): 310–16. http://dx.doi.org/10.26452/ijrps.v11ispl1.2718.
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Infection causing microbes spread through the air, water, contaminated food, cloth, equipment or from infected person to healthy one. The evidence collected on spreading mode of COVID-19 is mostly through skin contact and respiratory droplets. However, just in contact with the microbe is not enough to cause the disease. Reaching the germ to the internal body is the critical step involved in the manifestation of illness. Contact transmission for the sign of disease in an individual can occur from skin to the inner body especially when the infected part (mostly hands) reaches the mucous membrane of open cavities such as mouth, nose, eyes or open wound. Therefore the use of good quality sanitizers to prevent infections such as COVID-19 is one of the critical measures.Ayurveda is a rich source of vast information on therapeutic potentials of numerous herbs. Many simple to complex formulations can be prepared by using the therapeutic attributes of these herbs. Therefore in the present work, an attempt has been made to initiate the manufacturing of Ayurveda hand sanitizers based on various Ayurvedic medicated drugs mentioned in Samhitas, as developing countries such as India are facing a shortage of hand sanitizers which is a must prevent the spread of COVID-19. The shortage has resulted in an internal price hike, and thus there is a need for a homemade affordable way of sanitizing hands. Therefore by using a combination of antimicrobial, disinfectant, anti-allergic, skin disease curing herbs along can be recommended for the preparation of Ayurveda hand sensitizers. By using similar herbs, nasal spray and aerosols for cleaning and increasing the strength of the respiratory tract can also be prepared.
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Silva, Henrique. "A Descriptive Overview of the Medical Uses Given to Mentha Aromatic Herbs throughout History." Biology 9, no. 12 (December 21, 2020): 484. http://dx.doi.org/10.3390/biology9120484.
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Mints have been among the most widely used herbs for medicinal purposes since ancient civilizations. They are still presently used for numerous purposes, including non-medicinal, which makes them economically relevant herbs. Information regarding the medical and scientific uses given to mints throughout history are vastly scattered and/or incomplete. The aim of this paper is to provide an extensive descriptive overview of the medical uses given to these herbs, highlighting both the authors in medical culture responsible for their dissemination, as well as their major galenic formulations. Databases on medical science, reference textbooks on medical history, botanics (aromatic herbs), and pharmacognosy were consulted. The use of mints remotes to Classical Antiquity, with major contributions from Pliny the Elder. In the Middle Ages, the increased knowledge surrounding mints came from Byzantine physicians, while, in the Modern Age, technological developments allowed the production of mint-based products which have become part of elaborate galenic formulas employed by an increasing number of physicians, as well as have also stimulated both scientific and artistic interests alike. In present-day medicine, several mints and mint-based products are being researched as potential therapeutic alternatives for many diseases, while also being vastly employed in food and cosmetic industries.
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Liang, Willmann, David T. Yew, Kam Lun Hon, Chun Kwok Wong, Timothy C. Y. Kwok, and Ping Chung Leung. "The Indispensable Value of Clinical Trials in the Modernization of Traditional Chinese Medicine: 12 Years' Experience at CUHK and Future Perspectives." American Journal of Chinese Medicine 42, no. 03 (January 2014): 587–604. http://dx.doi.org/10.1142/s0192415x14500384.
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The last decade has seen a wealth of information reporting the beneficial effects of Chinese herbal medicines. While a lot more studies were done using in vitro and in vivo research platforms, much fewer investigations were conducted according to evidence-based requirements in clinical settings. The Institute of Chinese Medicine at the Chinese University of Hong Kong (CUHK) has had the opportunity to collaborate with clinicians over the years to initiate and conduct dozens of clinical trials investigating and verifying the therapeutic values of Chinese herbs in selected disease conditions. Of the many disorders, we chose to focus on those that are known for their difficulties achieving perfect results with conventional treatment methods. Examples include non-healing ulcers, allergic conditions, degenerative diseases and cancer. Protective effects of the herbs in such chronic diseases as coronary artery disease and osteoporosis were also part of our focus. Even in healthy individuals and those recovering from chemotherapy, Chinese herbs could help with the immune system and were studied in our clinical trials as well. This paper aims to highlight the important findings from these clinical studies while at the same time, stressing the indispensable value of clinical trials in modernizing the use of Chinese herbs in present-day medicine.
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Mannina, Natassia Bacco, Daniela Magalhães Drummond de Mello, Priscilla Carla Dos Santos Costa, João Paulo Bastardo Rodrigues, and João Victor Da Silveira Bertão. "Use of a porous cellulose membrane (Membracel®) and moxibustion for severe excoriative injury in a chilean skua (Catharacta chilensis)." Brazilian Journal of Veterinary Research and Animal Science 55, no. 2 (June 30, 2018): e138489. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2018.138489.
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The use of alternative therapeutic approaches in wild animals has gained notoriety due to its efficiency, low cost and reduced or nonexistent stressors. The present study evaluated the efficacy of treatment of a bilateral excoriative lesion in the region of the dorsal metacarpus in a Chilean skua (Catharacta chilensis) in a rehabilitation process with the use of a porous cell membrane, sold commercially, in concomitance with moxibustion sessions with herbs (Artemisia vulgaris). The healing time of 14 days was reduced when compared to traditional techniques and proved the viability and efficacy of the treatment.
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Chhabra, Anshu, Gurvinder Singh, and Yash Upadhyay. "A Review on Herbal Drug Interaction." Asian Journal of Pharmaceutical Research and Development 8, no. 1 (February 14, 2020): 94–99. http://dx.doi.org/10.22270/ajprd.v8i1.663.
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Herbal medicines are becoming popular worldwide, despite their mechanisms of action being generally unknown, the lack of evidence of efficacy, and inadequate toxicological data. An estimated one third of adults in developed nations and more than 80% of the population in many developing countries use herbal medicines in the hope of promoting health and to manage common maladies such as colds, inflammation, heart disease, diabetes and central nervous system diseases. To date, there are more than 11 000 species of herbal plants that are in use medicinally and, of these, about 500 species are commonly used in Asian and other countries. These herbs are often co-administered with therapeutic drugs raising the potential of drug–herb interactions, which may have important clinical significance based on an increasing number of clinical reports of such interactions.The interaction of drugs with herbal medicines is a significant safety concern, especially for drugs with narrow therapeutic indices (e.g. warfarin and digoxin). Because the pharmacokinetics and/or pharmacodynamics of the drug may be altered by combination with herbal remedies, potentially severe and perhaps even life-threatening adverse reactions may occur. Because of the clinical significance of drug interactions with herbs, it is important to identify drugs and compounds in development that may interact with herbal medicines. Timely identification of such drugs using proper in vitro and in vivo approaches may have important implications for drug development.
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Huan, Jia-Ming, Wen-Ge Su, Wei Li, Chao Gao, Peng Zhou, Chun-Sheng Fu, Xiao-Feng Wang, Yi-Min Wang, and Yi-Fei Wang. "Summarizing the Effective Herbs for the Treatment of Hypertensive Nephropathy by Complex Network and Machine Learning." Evidence-Based Complementary and Alternative Medicine 2021 (June 11, 2021): 1–12. http://dx.doi.org/10.1155/2021/5590743.
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Hypertensive nephropathy is a common complication of hypertension. Traditional Chinese medicine has been used in the clinical treatment of hypertensive nephropathy for a long time, but the commonly used prescriptions have not been summarized, and the basic therapeutic approaches have not been discussed. Based on data from 3 years of electronic medical records of traditional Chinese medicine used at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, a complex network and machine learning algorithm was used to explore the prescribed herbs of traditional Chinese medicine in the treatment of hypertensive nephropathy (HN). In this study, complex network algorithms were used to describe traditional Chinese medicine prescriptions for HN treatment. The Apriori algorithm was used to analyze the compatibility of these treatments with modern medicine. Data on the targets and regulatory genes related to hypertensive nephropathy and the herbs that affect their expression were obtained from public databases, and then, the signaling pathways enriched with these genes were identified on the basis of their participation in biological processes. A clustering algorithm was used to analyze the therapeutic pathways at multiple levels. A total of 1499 prescriptions of traditional Chinese medicines used for the treatment of hypertensive renal damage were identified. Fourteen herbs used to treat hypertensive nephropathy act through different biological pathways: huangqi, danshen, dangshen, fuling, baizhu, danggui, chenpi, banxia, gancao, qumai, cheqianzi, ezhu, qianshi, and niuxi. We found the formulae of these herbs and observed that they could downregulate the expression of inflammatory cytokines such as TNF, IL1B, and IL6 and the NF-κB and MAPK signaling pathways to reduce the renal inflammatory damage caused by excessive activation of RAAS. In addition, these herbs could facilitate the deceleration in the decline of renal function and relieve the symptoms of hypertensive nephropathy. In this study, the traditional Chinese medicine approach for treating hypertensive renal damage is summarized and effective treatment prescriptions were identified and analyzed. Data mining technology provided a feasible method for the collation and extraction of traditional Chinese medicine prescription data and provided an objective and reliable tool for use in determining the TCM treatments of hypertensive nephropathy.
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Ida Christi V E, Krishnaprabha C, Blesson Sha Fogarty N I, Sangilimuthu A, and Kumutha D. "Estimation of Heavy Metals in Selected Medicinal Herbs." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (August 7, 2020): 4619–24. http://dx.doi.org/10.26452/ijrps.v11i3.2745.
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Worldwide nearly 80% of peoples are using the medicinal plants for basic illness due to the presence of primary metabolites, secondary metabolites, minerals and inorganic salts. Some Inorganic minerals available in plants are useful for health and have therapeutic value and some heavy metals are dangerous for health and may cause damage to internal organs. In view of that, the present study designed to quantitatively evaluate the presence of inorganic minerals like Sodium, Potassium, Calcium, Magnesium, Zinc and Copper and heavy metal like Mercury, Arsenic, Lead, Cadmium, Selenium, Cobalt and Chromium in selected medicinal herbs using Flame photometric method and tomic absorption method There is a limitation for the presence of heavy metals in herbal drugs, The distributions of these metals are not uniform all areas, so before using for formulation development all herbs should be taken for the estimation of heavy metals. In this study an attempt to estimate the inorganic elements and heavy metals present in some of the important medicinal plants like Moringa oleifera Lam, Achyranthes aspera Linn, Scoparia dulcisLinn, Achyranthes aspera Linn. Castus pictus Linn, are mostly used in traditional medicines. Based on the analysis, the result shows the minerals like Sodium, Potassium, Calcium, Magnesium, Zinc and Copper were present in considerable quantity e and heavy metals like Mercury, Arsenic, Lead, Cadmium, Selenium, Cobalt and Chromium were within the limit as per WHO standard values. ed plants are containing heavy metals were within the limit as per WHO standard. Further these medicinal plants can use for new herbal formulations.
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Hussain, Syed Ammar, Ahsan Hameed, Furqan Nasir, Yang Wu, Hafiz Ansar Rasul Suleria, and Yuanda Song. "Evaluation of the Spermatogenic Activity of Polyherbal Formulation in Oligospermic Males." BioMed Research International 2018 (July 25, 2018): 1–10. http://dx.doi.org/10.1155/2018/2070895.
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The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo eitherin vitrofertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59±4.37×106/mL to25.61±8.6×106/mL; P ≤0.001), 154% increase in semen volume (1.7±0.14 mL to4.32±0.38 mL; P ≤0.001), and 215% increase in sperm motility (15.43±2.40% to48.65±5.10%; P ≤ 0.001) on day 90 from baseline. Furthermore, a significant improvement and regulation were also observed in serum hormone levels with PHF treatment as compared to the placebo group. The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.
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Pal, Rashmi Saxena, Yogendra Pal, Ankita Wal, and Pranay Wal. "Herbal Dentifrices: Emerging Trends and Patterns." Current Traditional Medicine 6, no. 1 (January 8, 2020): 54–64. http://dx.doi.org/10.2174/2215083805666190626145755.
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Background: Herbal extracts have been employed since ages in dentistry as tooth cleansing and antimicrobial agents. The use of herbal medicines continues to expand and trend rapidly across the world. Herbal extracts have been used in dentistry for multiple uses as reducing inflammation, as antimicrobial plaque agents, for preventing release of histamine and as antiseptics, antioxidants, antimicrobials and analgesics. They also aid in healing process and are very effective in controlling microbial plaque and other disorders related to gums. Objective: The present review aims towards the combined review as well as compilation of available herbs under the category of various dental associated problems. Materials and Methods: The herbs were studied by sectioning them as for looking after different works or findings done against dental caries, tooth ache, scouring teeth, gum troubles and herbs as mouth fresheners. Results: Herbal extracts have been used on a large scale in dentistry as tooth cleansing and antimicrobial plaque agents. Many people take herbal derived medicines or herbal based products for the purpose of reducing inflammation, as antimicrobial agents, for preventing release of histamine and as antiseptics, antioxidants, antifungals, antibacterials, antivirals and analgesics. Herbal extracts are used in dentistry for treatment of various dental disorders. Conclusion: The use of herbal medicines are blooming rapidly across the world. Herbal extracts and the various herbs on the whole or their specific parts have been used in dentistry. They relieve the problems of gums and act as excellent mouth fresheners. The natural herbal remedies act as an effective substitute to antibiotics and represent a promising approach for prevention and as therapeutic strategies for various oral infections as they are natural, eradicate the problem from its root and provide long lasting relief. The herbal remedies are advantageous over conventional treatment.
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Adeep Kujur, Rakesh Tirkey, Vaibhav Tripathi, and Pushpendra Kumar Sahu. "Promising herbs for the management of inৎlammation associated with various pathological conditions - A Review." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 21, 2020): 3084–91. http://dx.doi.org/10.26452/ijrps.v11ispl4.4620.
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Ailments with ignescent etiopathology have expanded in rate lately. Medications utilized for restorative administration of such provocative ailments are alleviating the disease and yet additionally countering genuine perilous outcome. Allopathic medications really pejorate the disease condition in patients, particularly with rheumatoid joint pain and osteoarthritis. Add to this the huge number of individuals detriment by these medications, as well as their huge expenses and the need of using reciprocal means become obvious. On the other hand, natural medicines offer one engaging approach to decrease the use of allopathic non- narcotic anti- phlogistic agents. The reason for administering herbs incorporate long accounts of utilization, a broad examination on various natural constituents, the relative simplicity of administration profile, economical and magnificent security records. So far, Many Phyto-constituents are investigated for numerous therapeutic applications, albeit a large fraction of these reports are of scholarly interest, only some of them get a pass for clinical preliminaries. Future exploration should look into the molecular mechanisms of various therapeutic applications of the natural plants in different ailments associated with inflammation. This review is a compilation of anti-inflammatory natural agents along with reported action path. We have summarized all necessary information regarding the title with the aid of best possible sources.
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Nagi, Ravleen. "Therapeutic Role of Phytochemicals in the Prevention of Oral Potentially Malignant Disorders and Oral Cancer – A Review." Journal of Evolution of Medical and Dental Sciences 10, no. 16 (April 19, 2021): 1156–65. http://dx.doi.org/10.14260/jemds/2021/246.
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BACKGROUND Medicinal plants and their extracts have been found to possess potent antiinflammatory, antioxidant and anti-cancer properties that slow down the cellular proliferation and malignant transformation rate of orally potential malignant disorders such as oral leukoplakia, oral submucous fibrosis and oral lichen planus. They are a potential source of antioxidants such as vitamin A, E, and C that neutralize the free radicals produced in various oral mucosal lesions thereby preventing the mucosal damage. They have been found to modulate cellular signalling pathways and, this activation influences the cellular defence mechanisms that protect the normal cells against reactive oxygen species or reactive metabolites and induces apoptotic death of cancerous cells, thus chemoprevention ensues to prevent, reverse or delay carcinogenesis. They have been studied to enhance tumour cell killing and inhibition of metastasis by increasing number of immunocompetent cells such as macrophages, cytotoxic T lymphocytes, natural killer cells and by recruitment of antibodies at the tumour site. Now a days, natural herbs or phytochemicals are gaining attention due to side effects and increased antimicrobial resistance that often occur with prolonged use of chemotherapeutic agents. Therapeutic effect of phytochemicals in oral PMDs is very promising as they prevent the progression of dysplasia from mild to severe. Literature has revealed significant reduction in burning sensation, difficulty in swallowing and speech, and pain associated with the oral mucosal lesion. However, more research should be conducted in future to establish their use as an adjunctive therapy in oral potentially malignant disorders. By this review, an attempt has been made to highlight therapeutic potential of diverse herbs such as aloe vera, tulsi, neem, curcumin, lycopene, green and black tea, peppermint etc. in the reduction of clinical symptoms of burning sensation and pain associated with the oral mucosal lesions, and discusses their indispensable role in prevention of oral cancer. KEY WORDS Antioxidants, Chemoprevention, Phytochemicals, Oral Cancer
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Al-Rabia, Mohammed W., and Hani Z. Asfour. "The Extent and Reasons behind Herbal Medicine use among Saudis Herbal Consumers in Jeddah." Saudi Journal of Internal Medicine 7, no. 1 (June 30, 2017): 25–30. http://dx.doi.org/10.32790/sjim.2017.7.1.4.
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Background: Herbal remedies became common in both developed and developing countries although it is more prevalent in the latter. It is considered as a natural, acceptable, safe alternative to routine medicines. Objectives: This study aims to determine the extent and the character of herbal medicine use among Saudis in Jeddah and to identify the reasons behind its use and perceptions about its therapeutic outcome. Subjects and Methods: This comparative cross sectional study was conducted in randomly selected three primary health care centers in south Jeddah, Saudi Arabia over two consecutive weeks in 2016 by using a self-administered questionnaire. Data analysis was done by Statistical Package for Social Sciences version 16.Results: Three hundred Saudis participated in the study with mean age (25 ± 11.4) year. 70% of the participants were using herbs in the past with 70% of them having used it for the treatment of acute conditions. A high significant prevalence of herbal use was recognized among the older age group (86.20%), females (87.50%), and people with low educational levels (83.40%). Myrrh (57.10%), ginger (50.40%), and black seeds (42.80%) were the most commonly used herbs by the participants. The most common reasons behind herbal use as a medication were accessibility (50%) and family and friends recommendation (50%). Conclusion: Herbal medicine use is considered common among Saudi citizens in Jeddah, especially among the older age, females and low educational levels and these groups should be targeted with orientation programs about the eff ectiveness, benefi ts and side effects.
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Bhatt, Narendra Someshwar, and Manasi Deshpande. "A Critical Review and Significance of Ayurvedic preparation Kwatha - Herbal decoction." International Journal of Ayurvedic Medicine 11, no. 2 (July 3, 2020): 155–64. http://dx.doi.org/10.47552/ijam.v11i2.1495.
Full textAbstract:
The standardization of Ayurvedic classical dosage forms has been an area of academic, research, industrial and regulatory interests. It is crucial to understand the basic principles and rationality of these dosage forms for their therapeutic relevance while adapting to newer technologies for its right pharmaceutical and clinical use. Kwatha Kalpana -frequently referred to as decoctions - aqueous extraction of a group of herbs, is one of the most commonly used classical dosage forms where the therapeutic attributes are extracted from the group of botanicals into water, with the use of heat. Though clinically effective, it is seldom used due to the cumbersome preparatory method, short shelf life and poor palatability. This elaborate review covers historical and basic concepts of the dosage form, its salient features, nuances of classical preparations, traditional and newly developed methods of preparations. This paper covers intricate classical information and specifics about Kwatha, the herbal decoction.