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Journal articles on the topic 'Hericenones'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Iacovelli, Riccardo, Fons Poon, and Kristina Haslinger. "Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom)." Molecules 29, no. 23 (2024): 5576. http://dx.doi.org/10.3390/molecules29235576.

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Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies, including the meroterpenoids hericenones. Here, we report the identification and reconstitution of the first two steps of the biosynthetic pathway of hericenones via heterologous expression of the polyketide synthase HerA and the carboxylic acid reductase HerB in Aspergillus oryzae. Furthermore, we investigated a putative prenyltransferase that mig

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Corana, Federica, Valentina Cesaroni, Barbara Mannucci, et al. "Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore." Molecules 24, no. 19 (2019): 3511. http://dx.doi.org/10.3390/molecules24193511.

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Hericium erinaceus is a medicinal mushroom that contains many molecules promising a plethora of therapeutic properties. In this study, the strain H.e.2 (MicUNIPV, University of Pavia, Italy) was isolated from a sporophore collected in Tuscany (Italy). Mycelium, primordium, and wild type and cultivated sporophores were analyzed by HPLC-UV-ESI/MS. Erinacine A in the mycelium and hericenones C and D in the sporophores were quantified by comparison with their standard molecules. For the first time, H. erinaceus primordium was also investigated for the presence of these molecules. Comparing with th

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Basko, Ihor, and Laurie Dohmen. "Lion’s Mane (Hericium erinaceus): A Potential Treatment for Neurologic Disorders in Veterinary Medicine." Journal of the American Holistic Veterinary Medical Association 70, Spring (2023): 15–20. http://dx.doi.org/10.56641/pssj9210.

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The use of the culinary and medicinal mushroom Lion’s Mane (LM) (Hericium erinaceus) has been extensively researched. Much of the recent research has been fueled by interest in using LM to prevent and treat neurological diseases such as cognitive decline, dementia, Parkinson’s disease, and Alzheimer’s disease and to stimulate peripheral nerve regeneration. This mushroom is rich in physiologically important components. The main bioactive phytochemicals extracted from LM’s fruiting body and mycelia are hericenones, erinacines, polysaccharides, and dilinoleoyl-phosphatidylethanolamine (DLPE). β-g

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Kawagishi, Hirokazu, Motoharu Ando, Kayoko Shinba, et al. "Chromans, hericenones F, G and H from the mushroom Hericium erinaceum." Phytochemistry 32, no. 1 (1992): 175–78. http://dx.doi.org/10.1016/0031-9422(92)80127-z.

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Ma, Bing-Ji, Jin-Wen Shen, Hai-You Yu, Yuan Ruan, Ting-Ting Wu, and Xu Zhao. "Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis inHericium erinaceus." Mycology 1, no. 2 (2010): 92–98. http://dx.doi.org/10.1080/21501201003735556.

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Kawagishi, Hirokazu. "Chemical studies on bioactive compounds related to higher fungi." Bioscience, Biotechnology, and Biochemistry 85, no. 1 (2021): 1–7. http://dx.doi.org/10.1093/bbb/zbaa072.

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Abstract Hericium erinaceus (Yamabushitake in Japan) is a well-known edible and medicinal mushroom. We discovered antidementia compounds, hericenones C to H, from the fruiting bodies and erinacine A to I from the cultured mycelia of the fungus. Based on the data of the compounds, several clinical experiments were performed using the fungus. “Fairy rings” is a phenomenon that turfgrass grows more prolific or inhibited than the surrounding area as a ring and then occasionally mushrooms develop on the ring. We found fairy-ring causing principles “fairy chemicals” and the biosynthetic routes of th

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Kobayashi, Shoji, Tomoki Tamura, Mizuho Koshishiba, et al. "Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C–H and Their Derivatives." Journal of Organic Chemistry 86, no. 3 (2021): 2602–20. http://dx.doi.org/10.1021/acs.joc.0c02681.

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Kobayashi, Shoji, Hidetsugu Tamanoi, Yuichi Hasegawa, Yusuke Segawa, and Araki Masuyama. "Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B, and I, Hericenols B–D, and Erinacerins A and B." Journal of Organic Chemistry 79, no. 11 (2014): 5227–38. http://dx.doi.org/10.1021/jo500795z.

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9

Szućko-Kociuba, Izabela, Alicja Trzeciak-Ryczek, Patrycja Kupnicka, and Dariusz Chlubek. "Neurotrophic and Neuroprotective Effects of Hericium erinaceus." International Journal of Molecular Sciences 24, no. 21 (2023): 15960. http://dx.doi.org/10.3390/ijms242115960.

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Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis. The active compounds in the mushroom, such as erinacines and hericenones, have been the subject of research, providing evidence of their neuroprotective effects. Further research and standardization processes for dietary supplements focused on H. erinaceus are essential to ensuring effec

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10

Kostanda, Elizabeth, Sanaa Musa, and Idan Pereman. "Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview." International Journal of Molecular Sciences 25, no. 11 (2024): 5949. http://dx.doi.org/10.3390/ijms25115949.

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In recent years, research on mushrooms belonging to the Hericium genus has attracted considerable attention due to their unique appearance and well-known medicinal properties. These mushrooms are abundant in bioactive chemicals like polysaccharides, hericenones, erinacines, hericerins, resorcinols, steroids, mono- and diterpenes, and corallocins, alongside essential nutrients. These compounds demonstrate beneficial bioactivities which are related to various physiological systems of the body, including the digestive, immune, and nervous systems. Extensive research has been conducted on the isol

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Kobayashi, Shoji, Hidetsugu Tamanoi, Yuichi Hasegawa, Yusuke Segawa, and Araki Masuyama. "ChemInform Abstract: Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B, and I, Hericenols B-D, and Erinacerins A and B." ChemInform 45, no. 48 (2014): no. http://dx.doi.org/10.1002/chin.201448209.

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12

Kawagishi, Hirokazu, Motoharu Ando, Hideki Sakamoto, et al. "Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum." Tetrahedron Letters 32, no. 35 (1991): 4561–64. http://dx.doi.org/10.1016/0040-4039(91)80039-9.

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13

Ratto, Daniela, Federica Corana, Barbara Mannucci, et al. "Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging." Nutrients 11, no. 4 (2019): 715. http://dx.doi.org/10.3390/nu11040715.

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Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailt

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Stankevič, Karolina, Kamila Fuczyło, Ewelina Kopczyńska, et al. "The Usage of Lion’s Mane in Sports and Its Metabolic Impact – a literature review." Quality in Sport 37 (January 21, 2025): 57190. https://doi.org/10.12775/qs.2025.37.57190.

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Introduction Lion’s mane (Hericium erinaceus), a medicinal mushroom widely recognized for its neuroprotective and health-promoting properties, has garnered increasing attention in recent years for its potential applications in sports and metabolic health. Known for its bioactive compounds, such as hericenones and erinacines, lion’s mane has demonstrated antioxidant, anti-inflammatory, and cognitive-enhancing properties that may benefit athletes. This review explores current research on the metabolic and sports-related effects of lion’s mane, highlighting both promising findings and gaps in the

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15

KYATHAM, RAMADEVI RAJU BATHULA NARENDER BOGGULA. "A REVIEW ON HERICIUM ERINACEUS: NATURE'S MEDICINAL RESERVOIR." Journal of Pharma Research 11, no. 05 (2022): 44–50. https://doi.org/10.5281/zenodo.7266249.

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<strong>ABSTRACT</strong> Mushrooms are rapidly becoming recognized as a promising source of novel proteins. Hericium erinaceus is one of the widely used edible mushrooms around the world, primarily in Asian countries. H. erinaceus is used in traditional medicines, and mushroom-based foods. Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in som

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Contato, Alex Graça, and Carlos Adam Conte-Junior. "Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review." Nutrients 17, no. 8 (2025): 1307. https://doi.org/10.3390/nu17081307.

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Hericium erinaceus, commonly known as lion’s mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview of the nutritional and therapeutic potential of H. erinaceus, with a particular focus on its anti-inflammatory, antioxidant, and antimicrobial activities. A structured literature search was performed using databases such as PubMed, Scopus, Science Direct, Web of Science, Science Direct, and Google Scholar. Studies published in the last two decades

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Amaranthus, Mike. "Lion’s Mane for Your Brain and Body." Journal of Food and Nutrition Sciences 13, no. 2 (2025): 85–92. https://doi.org/10.11648/j.jfns.20251302.14.

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Lion’s mane&lt;i&gt; (Hericium erinaceus&lt;/i&gt;) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sauté

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Masum, Md Habib Ullah, Syed Mohammad Lokman, Rehana Parvin, et al. "Novel fungal metabolites as dual cholinesterase inhibitors: A computational approach for Alzheimer’s disease therapy." PLOS One 20, no. 6 (2025): e0326219. https://doi.org/10.1371/journal.pone.0326219.

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Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is a major global health concern, affecting millions worldwide, with its prevalence expected to triple by 2050. Despite the widespread use of traditional drugs like cholinesterase inhibitors and NMDA receptor antagonists, their limited effectiveness requires innovative therapeutic approaches. This work used Computer-Aided Drug Design (CADD) to renovate AD therapies aimed at both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) using fungal secondary metabolites. Subsequent pharmacokinetic profiles indicated that a

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19

Tamrakar, Sonam, Dongmei Wang, Eri Hiraki, et al. "Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound." Molecules 28, no. 11 (2023): 4549. http://dx.doi.org/10.3390/molecules28114549.

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Hericium erinaceus, a mushroom species commonly known as Yamabushitake in Japan, is known to have a stimulatory effect on neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Hericenone C, a meroterpenoid with palmitic acid as the fatty acid side chain, is reported to be one such stimulant. However, according to the structure of the compound, the fatty acid side chain seems highly susceptible to lipase decomposition, under in vivo metabolic conditions. To study this phenomenon, hericenone C from the ethanol extract of the fruiting body was subje

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20

Phan, Chia-Wei, Guan-Serm Lee, Sok-Lai Hong, et al. "Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways." Food Funct. 5, no. 12 (2014): 3160–69. http://dx.doi.org/10.1039/c4fo00452c.

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21

Chen, Zhixia (Grace), Karen Suzanne Bishop, Hartono Tanambell, Peter Buchanan, Chris Smith, and Siew Young Quek. "Characterization of the bioactivities of an ethanol extract and some of its constituents from the New Zealand native mushroom Hericium novae-zealandiae." Food & Function 10, no. 10 (2019): 6633–43. http://dx.doi.org/10.1039/c9fo01672d.

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In this study, we investigated the potential bioactivities of an ethanol extract of Hericium novae-zealandiae and four of its constituents, namely hericenone C, hericene B, ergosterol and ergosterol peroxide.

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22

Joradon, Pinida, Vilai Rungsardthong, Uracha Ruktanonchai, et al. "A comparative study of conventional and supercritical carbon dioxide extraction methods for the recovery of bioactive compound from Lion’s Mane mushroom (Hericium erinaceus)." E3S Web of Conferences 355 (2022): 02015. http://dx.doi.org/10.1051/e3sconf/202235502015.

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Lion’s Mane mushroom (Hericium erinaceus), LM, is a medicinal mushroom which has various bioactive compounds within its fruiting bodies. However, during the cultivation, a large amount of the irregular-shape LM (Ir-LM) was generated. This mushroom type was considered a mushroom by-product. In this study, conventional solvent extraction (Maceration) and supercritical fluid extraction using carbon dioxide (SCFE-CO2) were performed to compare the recovery of ergosterol, hericenone C, and hericene A content from Reg-LM and Ir-LM fruiting bodies. Furthermore, two extraction conditions (40°C at 200

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Roda, Elisa, Erica Cecilia Priori, Daniela Ratto, et al. "Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging." International Journal of Molecular Sciences 22, no. 12 (2021): 6379. http://dx.doi.org/10.3390/ijms22126379.

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Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of H. erinaceus, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathway

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Kawagishi, Hirokazu, Motoharu Ando, and Takashi Mizuno. "Hericenone A and B as cytotoxic principles from the mushroom." Tetrahedron Letters 31, no. 3 (1990): 373–76. http://dx.doi.org/10.1016/s0040-4039(00)94558-1.

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Rama Rao, A. V., and Ravindra G. Reddy. "First unambiguous total synthesis of hericenone A: Proposed structure revised." Tetrahedron Letters 33, no. 28 (1992): 4061–64. http://dx.doi.org/10.1016/0040-4039(92)88100-j.

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26

Tachabenjarong, Nattapat, Vilai Rungsardthong, Uracha Ruktanonchi, et al. "Bioactive compounds and antioxidant activity of Lion’s Mane mushroom (Hericium erinaceus) from different growth periods." E3S Web of Conferences 355 (2022): 02016. http://dx.doi.org/10.1051/e3sconf/202235502016.

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Lion’s Mane mushroom (Hericium erinaceus) is one of the most popularly edible and medicinal mushrooms. However, there is still a lack of knowledge on the relationship between growth period and bioactive content in the mushroom. The objectives of this research were to study bioactive compounds and antioxidant activity of Lion’s Mane mushroom at various growth periods. The mushroom was cultivated and harvested at growth periods of 14, 21, and 28-days. The samples were dried by lyophilization and extracted with ethanol. Bioactive compounds (ergosterol, hericenone C, and hericene A), total phenoli

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MA, Bing-Ji, Jin-Chuan MA, and Yuan RUAN. "Hericenone L, a new aromatic compound from the fruiting bodies of Hericium erinaceums." Chinese Journal of Natural Medicines 10, no. 5 (2012): 363–65. http://dx.doi.org/10.1016/s1875-5364(12)60072-7.

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28

Mori, Koichiro, Haruhisa Kikuchi, Yutaro Obara, et al. "Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation." Phytomedicine 17, no. 14 (2010): 1082–85. http://dx.doi.org/10.1016/j.phymed.2010.05.004.

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29

Omolo, Josiah Ouma, Heidrun Anke, and Olov Sterner. "Hericenols A–D and a chromanone from submerged cultures of a Stereum species." Phytochemistry 60, no. 4 (2002): 431–35. http://dx.doi.org/10.1016/s0031-9422(02)00070-5.

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30

Cordes, Jens, Frederick Calo, Katie Anderson, et al. "Total Syntheses of Angelicoin A, Hericenone J, and Hericenol A via Migratory Prenyl- and Geranylation–Aromatization Sequences." Journal of Organic Chemistry 77, no. 1 (2011): 652–57. http://dx.doi.org/10.1021/jo202354j.

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Omolo, Josiah Ouma, Heidrun Anke, and Olov Sterner. "ChemInform Abstract: Hericenols A-D and a Chromanone from Submerged Cultures of a Stereum Species." ChemInform 33, no. 42 (2010): no. http://dx.doi.org/10.1002/chin.200242234.

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Xie, Guangbo, Lan Tang, Yu Xie, and Liyuan Xie. "Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities." Molecules 27, no. 7 (2022): 2157. http://dx.doi.org/10.3390/molecules27072157.

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Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl linoleate (2); ethyl linoleate (3); linoleic acid (4); hericene A (5); hericene D (6); hericene E (7); ergosta-4,6,8(14),22-tetraen-3-one (8); hericenone F (9); ergosterol (10); ergosterol peroxide (11); 3β,5α,6α,22E-ergosta-7,22-diene-3,5,6-triol 6-oleate (12). The chemical structu

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Li, Junhao, Kengo Hamamura, Yuya Yoshida, et al. "Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65." Biochemical and Biophysical Research Communications 720 (August 2024): 150077. http://dx.doi.org/10.1016/j.bbrc.2024.150077.

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Kobayashi, Shoji, Ami Ando, Hiroyuki Kuroda, Shota Ejima, Araki Masuyama, and Ilhyong Ryu. "Rapid access to 6-bromo-5,7-dihydroxyphthalide 5-methyl ether by a CuBr2-mediated multi-step reaction: concise total syntheses of hericenone J and 5′-deoxohericenone C (hericene A)." Tetrahedron 67, no. 47 (2011): 9087–92. http://dx.doi.org/10.1016/j.tet.2011.09.104.

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"Hericium erinaceus - A Rich Source of Diverse Bioactive Metabolites." Fungal Biotec 1, no. 2 (2021): 10–38. http://dx.doi.org/10.5943/funbiotec/1/2/2.

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Hericium erinaceus (commonly known as lion’s mane mushroom) is an edible mushroom used in traditional Chinese medicine. It is a prolific producer of diverse bioactive metabolites with neuroprotective and neuroregenerative properties (e.g. β glucan polysaccharides, hericenones, erinacine terpenoids, isoindolinones, sterols, and myconutrients). Because of its anti inflammatory properties and promotion of nerve growth factor (NGF) gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus is used for the treatment of Alzheimer's as well as Parkinson's diseases. This review provides a

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Wang, Junhong, Jing Wu, Ryo Yamaguchi, et al. "Uncovering Hericenones from the Fruiting Bodies of Hericium erinaceus through Interdisciplinary Collaboration." Journal of Natural Products, December 26, 2024. https://doi.org/10.1021/acs.jnatprod.4c01018.

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Chen, Zhixia (Grace), Karen Suzanne Bishop, Jingying Zhang, and Siew Young Quek. "Neuroprotective and Anticarcinogenic Properties of Hericium Mushrooms and the Active Constituents Associated with These Effects: A Review." Food Science and Engineering, March 25, 2022, 69–90. http://dx.doi.org/10.37256/fse.3120221166.

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Hericium mushrooms are well known for their numerous medicinal benefits, of which neuroprotective and anticarcinogenic characteristics are two of the most reported properties. This review summarizes the research advances and techniques used to study these two advantages of Hericium mushrooms reported in the latest 20 years, namely between the years 2001 and 2021. Based on published research, the Hericium-unique compounds (e.g., hericenones and erinacines) and polysaccharides are the main active constituents associated with these two properties. It was reported that about 70 such secondary meta

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Li, Tsung-Ju, Tung-Yen Lee, Yun Lo, et al. "Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo." BMC Complementary Medicine and Therapies 21, no. 1 (2021). http://dx.doi.org/10.1186/s12906-021-03463-3.

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Abstract Background Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety. Hericium erinaceus mycelium has been widely investigated in both the in vivo studies and clinical trials for its neuroprotective functions because the mycelium contains hericenones and erinacines, which synthesize the nerve growth factor and brain-derived neurotrophic factor (BDNF). Re

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Surendran, Geyan, Jake Saye, Syahira Binti Mohd Jalil, et al. "Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study." Frontiers in Nutrition 12 (April 10, 2025). https://doi.org/10.3389/fnut.2025.1405796.

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IntroductionAnimal studies have suggested that Lion’s Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones. However, despite being an ingredient used both culinarily and therapeutically in the East, and more and more commonly in the West, limited research has focused on the immediate effects of H. erinaceus on the cognitive function and mood of healthy young adults.MethodsIn an acute randomized, placebo-controlled, double-blinded, cross-over intervention study, we investigated the potenti

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Duan, Yuanyuan, Jiaqi Wu, Fanfan Wang, et al. "Transcriptomic and metabolomic analyses provide new insights into the appropriate harvest period in regenerated bulbs of Fritillaria hupehensis." Frontiers in Plant Science 14 (February 15, 2023). http://dx.doi.org/10.3389/fpls.2023.1132936.

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IntroductionThe bulb of Fritillaria hupehensis, a traditional cough and expectorant medicine, is usually harvested from June to September according to traditional cultivation experience, without practical scientific guidance. Although steroidal alkaloid metabolites have been identified in F. hupehensis, the dynamic changes in their levels during bulb development and their molecular regulatory mechanisms are poorly understood.MethodsIn this study, integrative analyses of the bulbus phenotype, bioactive chemical investigations, and metabolome and transcriptome profiles were performed to systemat

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Khatib, Soliman, Idan Pereman, Elizabeth Kostanda, et al. "Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies." Metabolomics 21, no. 3 (2025). https://doi.org/10.1007/s11306-025-02257-9.

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Abstract Introduction Mushrooms contain besides proteins a diverse pallet of specialized metabolites bioactive in either beneficial or harmful manner. Therefore, mushrooms have been exploited by humans for centuries for dietary or medical purposes. For example, the edible and medicinal mushrooms Hericium erinaceus and Pleurotus eryngii are grown commercially around the world. In nature, H. erinaceus grows on old or dead tree trunks, and P. eryngii grows on Apiaceae plant roots, whereas in cultivation, they grow on substrates mainly consisting of dry wood chips, straw, and cereals. To make thei

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