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Dissertations / Theses on the topic 'Herpes zoster virus infection'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kennedy, Jarrod John. "Infection and Functional Modulation of Monocytes and Macrophages by Varicella Zoster Virus." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20485.

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Human herpesviruses are ubiquitous in almost all communities and species. Varicella Zoster Virus (VZV), an alphaherpesvirus, is the causative agent of chickenpox and shingles. VZV influences the immune system by evading immune recognition and subverting the immune response. This is predicated upon the susceptibility of immune cells to VZV infection, which also aids in the dissemination of VZV throughout the host. VZV infection of the immune cells is understudied and has likely limited our understanding of how VZV modulates the immune system. Human monocytes and macrophages are integral to reco

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2

Bajric, Amina. "Validering av Varicella Zoster virus och Herpes Simplex virus." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24474.

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Syftet med denna valideringsstudie är att värdera lämpligheten att överföra den manuella analysen av aktuell infektion av Varicella Zoster Virus (aVZV IgM) och Herpes Simplex Virus (aHSV IgM) med SIEMENS Enzygnost® till en av de automatiserade analysinstrumenten EUROIMMUN Analyzer I (ELISA) eller DiaSorin LIAISON® XL. Arbetet utfördes på Klinisk Mikrobiologi i Lund. Konsekutiva serumprover för VZV IgM (n=108) och för HSV IgM (n=116) från det vardagliga flödet analyserades, tillsammans med 10 PCR- eller serokonversion-konfirmerade positiva serumprover av primär infektion VZV och HSV samt 10 pos

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3

Busch, Dietmar [Verfasser]. "Varizella-Zoster-Virus: Windpocken und Herpes Zoster : eine szientometrische Analyse / Dietmar Busch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1025511360/34.

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4

Taha, Yusri A. "Virus genetic variation and host related factors in herpes zoster." Thesis, Queen Mary, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528994.

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5

Savill, Rachel. "Validering av realtids-PCR-metod för Herpes simplex- och Varicella-zoster virus." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för naturvetenskap och biomedicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27225.

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6

Sutherland, Jeremy Philip. "Characterisation of the immune response following natural herpes zoster reactivation and during post-herpetic neuralgia." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/9936.

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Varicella Zoster Virus (VZV) is responsible for two clinically distinct diseases; varicella (or chickenpox) during primary infection, and herpes zoster (or shingles) following reactivation. Herpes zoster involves active viral replication within the dorsal root ganglia (DRG), as well as in the innervated skin. Post-herpetic neuralgia (PHN) is the most common complication of herpes zoster. During PHN patients experience intense persisting pain generally in the same distribution as the original herpes zoster rash. There is very little known about the underlying pathology and pathogenesis of PHN.

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7

Persson, Julia. "Validering av en multiplex realtids-PCR för direkt detektion av Herpes simplex virus och Varicella zoster virus." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44982.

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8

Ferreira, Juliana Caires de Oliveira Achili. "Infecção por herpes zoster em pacientes com lúpus eritematoso sistêmico juvenil." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-10012017-110451/.

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Introdução: A reativação do vírus latente da varicela-zoster ocasiona infecção por herpes zoster tanto em pacientes hígidos quanto em portadores de doenças crônicas e autoimunes, como lúpus eritematoso sistêmico juvenil (LESJ). As informações sobre infecção por herpes zoster (HZ), seus fatores de risco e desfecho no LESJ são limitadas devido à pequena representação desta complicação em publicações anteriores, e revela a necessidade de mais estudos visando contribuir para o melhor cuidado aos pacientes. Objetivos: Avaliar a prevalência de infecção por HZ em uma população expressiva de pacientes

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9

Ewing, Stephen Michael George. "Herpes simplex virus type 1 infection of dendritic leucocytes." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:e83750b1-3aa7-452e-a876-be51690252be.

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10

McBride, Brian William. "Mucosal immune responses induced by herpes simplex virus infection." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254770.

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11

Brown, Elizabeth L. "Consequences of genital herpes simplex virus infection among vulnerable populations /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10885.

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12

Sayers, Charlotte. "Herpes simplex virus type 1 infection of human keratinocyte cells." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11112.

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Infection of herpes simplex virus type 1 (HSV-1) begins at the epidermis, a stratified layer composed primarily of keratinocytes. The physiologically relevant cell type for the study of HSV-1 assembly is therefore the human keratinocyte. Nonetheless, relatively little is known about the replication of HSV-1 in this natural host cell. Comparison of virus growth in monolayers of keratinocyte cells and Vero cells, a routinely used cell line for HSV-1 studies, revealed that these keratinocytes support a more productive virus replication than Vero cells. Furthermore, newly assembled virus is produc

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13

Sydorchuk, A. S., and E. J. Odey. "A Case Study of Herpes Zoster Ophtalmicus Reactivation in a Polymorbid Patient Following Primary Bacterial Keratoconjuctivitis." Thesis, "Chyst", 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10864.

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14

Simmonds, Peter. "Detection of antibody responses to infection with herpes simplex virus and human immunodeficiency virus." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26933.

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15

Williams, N. A. "The role of Langerhans cells in infection with herpes simplex virus." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235240.

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16

Lee, Jennifer Sohn. "Epigenetic Regulation of Lytic and Latent Herpes Simplex Virus 1 Infection." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467322.

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Epigenetic regulation plays a major role in whether the herpes simplex virus 1 (HSV-1) will initiate viral gene expression and lytic infection or instead suppress its gene expression and establish a latent infection. Prior to this study, it was known that cells respond to naked DNA by assembling chromatin to silence foreign genetic material. However, during lytic infection of epithelial cells, viral proteins VP16 and ICP0 have been implicated in limiting chromatin association and promoting euchromatic histone modifications on the HSV-1 genome. We hypothesized that the viral genome would also b

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17

LABAUNE, JEAN-MARC. "Infection herpetique neonatale : etude lyonnaise sur 5 ans." Lyon 1, 1994. http://www.theses.fr/1994LYO1M208.

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18

Littlejohn, Emma Sophie Vout. "The Sensitivity of Adenovirus and Herpes simplex virus to Honey." The University of Waikato, 2009. http://hdl.handle.net/10289/2804.

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Honey has been used for centuries as a medicine to treat various ailments and infections. A large amount of research has established that honey has potent antibacterial activity. However, the sensitivity to honey of viral species that cause infections has been studied in only a small number of cases. The aim of this study was to obtain data to clarify and extend knowledge obtained from these previous studies of honey's antiviral activity, and especially study those viruses that cause localised infections which have limited or no therapy available, which are suitable to treatment with topically

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19

Wong, Kiing Aik. "Age related seroepidemiological survey of measles, mumps, rubella, varicella zoster, herpes simplex type 1 and 2 viruses." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/age-related-seroepidemiological-survey-of-measles-mumps-rubella-varicella-zoster-herpes-simplex-type-1-and-2-viruses(7188f535-e90e-4e18-a5cb-9b5ed1a75c68).html.

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Age stratified seroepidemiological studies play a crucial role in the design and assessment of vaccination strategies. An existing multiplex bead immunoassay for measles, mumps, rubella and varicella zoster virus antibodies together with a newly developed multiplex bead immunoassay for herpes simplex virus type 1 and type 2 antibodies were used to investigate the age-related seroepidemiology of these viruses in England during 2012.To develop the HSV-1 and HSV-2 antibody assay, attempts were made to produce full length of HSV-1 and HSV-2 glycoprotein G using a baculovirus vector expression syst

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20

Gor, Dehila. "Investigation of herpes simplex virus and Cytomegalovirus infection in the immunocompromised host." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323037.

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21

Laycock, K. A. "Herpes simplex virus gene expression in establishment and maintenance of latent infection." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234807.

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22

Ramaswamy, Meghna. "The epidemiology and natural history of genital herpes simplex virus (HSV) infection." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445811/.

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Genital infection with herpes simplex virus type 2 (HSV -2) is increasingly common worldwide. The aims of this thesis were to investigate the epidemiology and natural history of genital herpes among GUM attendees with symptomatic genital herpes, and among HIV-l infected individuals. In our study of GUM attendees in the UK, we demonstrated HSV -1 to account for 9% of first episodes of genital herpes. These findings are in contrast with observations made elsewhere in the UK, where HSV -1 has accounted for >50% of first-episode cases. As most individuals with genital HSV -2 infection remain clini

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23

Cheung, Peter. "Brefeldin A arrests the maturation and egress of herpes simplex virus particles during infection." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29798.

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Herpes Simplex Virus (HSV) requires the host cell secretory apparatus for the maturation and egress of newly synthesized viral particles. Not only do viral glycoproteins rely on the host ER and Golgi compartments for their proper processing, it is believed that enveloped particles are transported through these same organelles for their export out of the cells. Brefeldin A (BFA) is a compound that induces retrograde movement of material from the Golgi apparatus to the ER and causes the disassembly of the Golgi complex. In this study, the effects of BFA on the propagation of HSV-1 in infected ce

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24

Gasilina, Anjelika. "Herpes Simplex Virus-1: Crosstalk Between the Host Immunity and the Virus during Infection, Latency and Reanimation." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444615.

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25

Arone, Blanco Maria. "Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-231319.

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Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. Both genetic and environmental factors contribute to the onset and progression of these diseases. However, despite intensive research, the underlying cause remains unclear. The role of viral infection as an environmental factor in the context of neurodegen

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26

Lee, Sung Seok. "The role of autonomic neurons in the pathegenesis of herpes simplex virus infection." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/64503.

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Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are major human pathogens. HSV establishes latency in the nervous system and reactivates to cause recurrent disease, resulting in transmission of progeny virions to naïve individuals. Though HSV-1 and HSV-2 share similar structure and genes, they have distinctive recurrence profiles. Generally, HSV-1 reactivation is associated with disease 'above the waist' and HSV-2 reactivation is associated with disease 'below the waist'. This phenomenon was described decades ago but still remains unexplained. The mechanism of HSV latent infection in t

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27

Rana, Hafsa. "Characterising the Initial Events of Herpes Simplex Virus Infection in Human Anogenital Tissue." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27310.

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Herpes simplex virus (HSV) infection has a high prevalence globally and is associated with increased risk of HIV infection. Understanding HSV immunopathogenesis is key to developing successful treatments which may also reduce HIV acquisition rates. HSV directly interacts with keratinocytes and antigen presenting cells, mainly mononuclear phagocytes (MNPs) via the HSV entry receptor nectin-1. We recently discovered a novel population of epidermal type 2 conventional dendritic cells (Epidermal cDC2s) in anogenital skin and mucosae that express CD11c and are more susceptible to infection by HSV-1

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28

Obasi, Angela I. N. "The epidemiology of herpes simplex virus type 2 infection in Mwanza region, Tanzania." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536824.

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29

Herbein, Georges. "L'infection à Herpesvirus humain type 6 (HHV-6) chez les transplantés : une étude rétrospective de 32 patients." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M098.

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30

Nicholls, S. M. "Herpes simplex virus infection in sensory ganglia of mice in vivo and in vitro." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379502.

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31

Collins, Terry Cordell. "The effect of HSV-2 infection on the expression of cellular mitochondrial aspartate aminotransferase." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266539.

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32

Mitterreiter, Johanna Gracia [Verfasser]. "Virus and Host Factors Involved in Herpes Simplex Virus Infection of the Human Nervous System / Johanna Gracia Mitterreiter." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2017. http://d-nb.info/1150336951/34.

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33

Van, Buren Lauren Kay. "HSV-1 Infection of C3H Central Nervous System Cell Lines." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1189746668.

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34

TARTIERE, LAFONT CHRISTINE. "Les meningo-encephalites infectieuses aigues a liquide clair de l'adulte : d'apres une etude retrospective de 36 cas observes au chru de clermont-ferrand, de janvier 1989 a septembre 1992." Clermont-Ferrand 1, 1993. http://www.theses.fr/1993CLF1M003.

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35

Kumaraswamy, Guttalu K. "INNATE AND ADAPTIVE HOST RESPONSE DURING THE INITIAL PHASE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN THE NEONATAL MOUSE." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1168650862.

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36

Speck, Peter Gerald. "Analysis of establishment of latent infection with a virulent strain of herpes simplex virus type 1 /." Title page, contents and abstract only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phs7415.pdf.

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37

Champion, Patrick D. "An analysis of Fourier transform infrared spectroscopy data to predict herpes simplex virus 1 infection." Atlanta, Ga. : Georgia State University, 2008. http://digitalarchive.gsu.edu/math_theses/62/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from title page (Digital Archive@GSU, viewed July 29, 2010) Yu-Sheng Hsu, committee chair; Gary Hastings, Jun Han, committee members. Includes bibliographical references (p. 41).

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38

Weinstein, Debra Lynn. "Major histocompatibility complex antigens in the rat CNS following herpes simplex virus type 1 infection." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27681.

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The present study was designed to determine major histocompatibility complex (MHC) expression in the rat CNS following a viral infection. Male Wistar rats were anesthetized with ether and the right cornea was repeatedly scratched with a 23.5 gage needle. A 30 microliter drop of Herpes Simplex Virus Type 1 (HSV1) (PFU 33,000/mL) was placed on the scarified cornea. Animals were sacrificed 3, 6, 8, 10, 12, and 30 days following infection. Following decapitation, the brains were removed and placed in Zamboni fixative for immersion fixation. Monoclonal antibodies against rat MHC class I/class II an

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39

Henriquez, Rodney Fabian. "Varicella Zoster Virus infection of human matured monocyte derived dendritic cells & its impact on their effector functions." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13624.

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Varicella Zoster Virus (VZV) is a species specific alpha human herpes virus that causes both Varicella (chickenpox) and Herpes Zoster (shingles) in human hosts. It has been hypothesized that host dendritic cells (DC) play a pivotal role in the pathogenesis of VZV during the early stages of infection. DC have previously been shown to be permissive to VZV infection and capable of transmitting the virus to human T lymphocytes. VZV has also been shown to employ a variety of mechanisms to evade detection and clearance by the host immune system. The primary aim of this study was to identify the und

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40

Bishop, S. A. "Herpes simplex virus infection and damage in the central nervous system : The role of the immune response." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376607.

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41

Goldthorpe, Sian Elinor. "Effects of guanosine analogues on herpes simplex virus type 1 infection in cell culture and in a murine model of herpes encephalitis." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386689.

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42

Ives, Angela M. "Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78862.

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Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and animal models. The viruses preferentially replicate and establish latency in different subtypes of sensory neurons, as well as in neurons of the autonomic nervous system that are highly responsive to stress hormones. To determine if stress-related hormones modulate productive and latent HSV-1 and HSV-2 i

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43

Hsu, Wei-Li. "Herpes simplex virus type-1 infection and ND10 characteristics in cultured fibroblast and neuronal-like cells." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/3962/.

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Nuclear domain 10 (ND10) are punctate subnuclear structures that exist in most cell types. It has been suggested that ND10 structures serve as the site for initial viral genome deposition and some viral proteins, such as the ICP0 protein of HSV-1, have been shown to colocalise to, and subsequently induce the degradation of, proteins present in ND10. However the exact function of ND10 during HSV-1 infection is still unknown. In this study, the potential role of ND10 in HSV-1 infection was investigated by assessing the efficiency of viral IE and E gene expression or viral replication in cultured

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44

Lewis, David John. "Biological and clinical significance of chronic herpes virus infection in patients undergoing treatment for myeloid malignancies." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5832/.

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Cytomegalovirus (CMV) is a β-herpes virus that infects the majority of the world’s population. Tyrosine kinase inhibitors (in particular imatinib, dasatinib and nilotinib) have been successfully used in the treatment of chronic myeloid leukaemia, as they target the \(Abl\) kinase, which is constitutively activated in the disease. Although thought of as targeted therapies, they have significant “off target” effects including inhibition of \(Src\) family kinases important in T cell receptor mediated activation. I demonstrated that CMV infection is associated with significant alterations in the i

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45

Binks, Alexander William David. "The role of immunogenic cell death in oncolytic herpes simplex virus-1 infection of cancer cells." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30718/.

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Patients living with many cancers, including ovarian cancer (OC), often suffer from a lack of adequate treatment options. In the case of OC, primary debulking surgery followed by platinum and paclitaxel chemotherapy has led to a vast improvement in patient survival over the past few decades, however, rates of drug-resistant recurrence remain high. Research into new, experimental treatment options is therefore warranted for OC and other cancers. Oncolytic viruses (OVs) are replication-competent viruses that can selectively infect and destroy cancerous cell types, while leaving healthy cells unh

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46

Tscharke, David C. "Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09pht877.pdf.

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47

Chatterjee, Koushik. "A study of host genetic determinants of human papillomavirus (HPV) infection, cervical cancer and herpes simplex virus type-2 (HSV-2) infection." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/3160.

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48

Bryant, Helen Elizabeth. "Analysis of cellular and viral proteins that interact with the IE63 protein of herpes simplex virus type 1." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312135.

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49

Svensson, Alexandra. "Immune regulation of herpes simplex virus type 2 infection : special emphasis on the transcription Factor T-bet /." Göteborg : Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/852.

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50

Teo, Su Hui Catherine. "Spatiotemporal resolution of global protein synthesis during herpes simplex virus infection using bioorthogonal precursors and click chemistry." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/63934.

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Herpes simplex virus (HSV) modulates the host cell’s proteome and transcriptome during infection to fulfil the needs of the virus for productive replication and transmission. Using bioorthogonal precursors and click chemistry, I have examined spatiotemporal aspects of global protein synthesis during single step replication and cell-to-cell transmission with results revealing new insights into the complex spatial interplay between translational control processes, protein localisation and transcription during HSV infection. For the first time, translational suppression and recovery is visualised

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