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Journal articles on the topic 'Herpesvirus 4 Humano'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Reina, J., J. Gascó, X. Bestard, and F. Ballesteros. "Aislamiento del herpesvirus humano tipo 6 en la sangre de pacientes receptores de trasplante renal." Revista Clínica Española 200, no. 11 (2000): 644–45. http://dx.doi.org/10.1016/s0014-2565(00)70032-4.

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2

Stevenson, P. G., J. P. Simas, and S. Efstathiou. "Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4." Journal of General Virology 90, no. 10 (2009): 2317–30. http://dx.doi.org/10.1099/vir.0.013300-0.

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Many acute viral infections can be controlled by vaccination; however, vaccinating against persistent infections remains problematic. Herpesviruses are a classic example. Here, we discuss their immune control, particularly that of gamma-herpesviruses, relating the animal model provided by murid herpesvirus-4 (MuHV-4) to human infections. The following points emerge: (i) CD8+ T-cell evasion by herpesviruses confers a prominent role in host defence on CD4+ T cells. CD4+ T cells inhibit MuHV-4 lytic gene expression via gamma-interferon (IFN-γ). By reducing the lytic secretion of immune evasion pr

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3

Wright, Debbie E., Susanna Colaco, Camilo Colaco, and Philip G. Stevenson. "Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions." Journal of General Virology 90, no. 11 (2009): 2592–603. http://dx.doi.org/10.1099/vir.0.014266-0.

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Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic

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4

Nazaryan, R. S., Yu V. Fomenko, N. A. Scheblykina, T. A. Kolesova, N. V. Golik, and E. V. Sukhostavets. "Herpesviruses. Part 1." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 6 (2020): 299–307. http://dx.doi.org/10.26693/jmbs05.06.299.

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One of the urgent problems of modern medicine is the high incidence of herpesvirus infections. The high prevalence of herpesviruses in the human population of the world allow us to consider herpes a common systemic disease of the whole organism. Doctors of any specialty are faced with the clinical manifestations of herpes infection in patients, and they themselves are a risk group of chronic herpes infections formation due to constant patient contacts and frequent professional psycho-emotional overload. Herpes infections are a group of infectious diseases caused by human herpesviruses. Now it

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5

Prichard, Mark N., Debra C. Quenelle, Caroll B. Hartline, et al. "Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides." Antimicrobial Agents and Chemotherapy 53, no. 12 (2009): 5251–58. http://dx.doi.org/10.1128/aac.00417-09.

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ABSTRACT A series of 4′-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4′-thio-2′-deoxyuridine (4′-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound also has good activity in cell culture against many of the herpesviruses. It inhibited the replication of herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus with 50% effective concentrations (EC50s) of 0.1, 0.5, and 2 μM, respectively. It also inhibited the replication of h

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6

White, Douglas W., Catherine R. Keppel, Stephanie E. Schneider, et al. "Latent Murine Herpesvirus-4 Infection Arms NK Cells." Blood 114, no. 22 (2009): 3678. http://dx.doi.org/10.1182/blood.v114.22.3678.3678.

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Abstract Abstract 3678 Poster Board III-614 Natural killer (NK) cells are lymphocytes originally identified by their ability to kill target cells without prior sensitization. However, murine NK cells require an antecedent ‘arming’ event to translate cytotoxic effector proteins (perforin and granzymes) resulting in potent cytotoxic capacity. In contrast to mice, most NK cells (CD56dim) from the peripheral blood of healthy humans are armed with pre-formed perforin and granzyme B proteins and mediate killing of NK sensitive targets directly ex vivo. This suggests that NK cells from specific patho

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7

Rincón-Amador, Rubén Alejandro, and Rodolfo Fragoso-Ríos. "Virus de Epstein-Barr y su relación con la estomatología pediátrica. Una revisión narrativa." Casos y Revisiones de Salud 3, no. 1 (2021): 60–73. http://dx.doi.org/10.22201/fesz.26831422e.2021.3.1.7.

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Introducción. El Virus de Epstein-Barr (VEB) pertenece a la familia Herpesviridae y se clasifica como herpesvirus humano 4 (HVH-4). La prevalencia estimada a nivel mundial de infección por VEB rebasa el 95%. La mononucleosis infecciosa (MI), es una enfermedad sistémica producida en el 90% de ocasiones por el virus de VEB y que infecta al 95% de la población. Además, existe evidencia de que el VEB es un factor de riesgo para numerosas enfermedades inflamatorias orales como liquen plano oral (LPO), enfermedad periodontal y síndrome de Sjögren. La actualización del personal en este ámbito es fund

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8

Vider-Shalit, Tal, Vered Fishbain, Shai Raffaeli, and Yoram Louzoun. "Phase-Dependent Immune Evasion of Herpesviruses." Journal of Virology 81, no. 17 (2007): 9536–45. http://dx.doi.org/10.1128/jvi.02636-06.

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ABSTRACT Viruses employ various modes to evade immune detection. Two possible evasion modes are a reduction of the number of epitopes presented and the mimicry of host epitopes. The immune evasion efforts are not uniform among viral proteins. The number of epitopes in a given viral protein and the similarity of the epitopes to host peptides can be used as a measure of the viral attempts to hide this protein. Using bioinformatics tools, we here present a genomic analysis of the attempts of four human herpesviruses (herpes simplex virus type 1-human herpesvirus 1, Epstein-Barr virus-human herpes

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9

Jenson, Hal B., Yasmin Ench, Yanjin Zhang, Shou-Jiang Gao, John R. Arrand, and Michael Mackett. "Characterization of an Epstein–Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus)." Journal of General Virology 83, no. 7 (2002): 1621–33. http://dx.doi.org/10.1099/0022-1317-83-7-1621.

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A gammaherpesvirus related to Epstein–Barr virus (EBV; Human herpesvirus 4) infects otherwise healthy common marmosets (Callithrix jacchus). Long-term culture of common marmoset peripheral blood lymphocytes resulted in outgrowth of spontaneously immortalized lymphoblastoid cell lines, primarily of B cell lineage. Electron microscopy of cells and supernatants showed herpesvirus particles. There were high rates of serological cross-reactivity to other herpesviruses (68–86%), but with very low geometric mean antibody titres [1:12 to human herpesvirus 6 and 1:14 to Herpesvirus papio (Cercopithecin

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10

Marques Filho, Jaime S., Jorge Gobara, Gustavo Vargas da Silva Salomao, et al. "Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study." Mediators of Inflammation 2018 (August 6, 2018): 1–7. http://dx.doi.org/10.1155/2018/6020625.

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This study evaluated the presence of cytokines (IL-1β, IL-2, IL-4, IL-6, MCP-1, MIP-1α, MIP-1β, and TNF-α) and human herpesvirus (HSV1, HSV2, EBV, CMV, VZV, HHV6, HHV7, and HHV8) in saliva samples taken from subjects with and without peri-implantitis. Forty-two periodontally healthy subjects were divided according to peri-implant condition: healthy and peri-implantitis groups. The clinical parameters as probing depth, clinical attachment level, plaque index, gingival bleeding, bleeding on probing, and suppuration were evaluated. For cytokine detection, multiplex analysis was performed, and PCR

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11

Mätz-Rensing, K., K. D. Jentsch, S. Rensing, et al. "Fatal Herpes simplex Infection in a Group of Common Marmosets (Callithrix jacchus)." Veterinary Pathology 40, no. 4 (2003): 405–11. http://dx.doi.org/10.1354/vp.40-4-405.

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An outbreak of classical herpetic infection causing vesicoulcerative stomatitis in a family group (eight animals) of Callithrix jacchus is described. In all eight infected animals, human herpesvirus 1 (HHV-1) was identified as the causative agent. This was confirmed by histologic, immunohistologic, and molecular biologic investigations, as well as by virus isolation. The clinical picture, the macroscopic appearance, and the histologic results indicated a herpes infection as the cause of mortality. Alterations of the oral mucous membranes were erosive to ulcerative with typical intranuclear inc

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12

Yuan, Wei-yuan, Xue Chen, Ning-ning Liu, et al. "Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles." Medicinal Chemistry 15, no. 7 (2019): 801–12. http://dx.doi.org/10.2174/1573406414666181109095239.

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Background: Clinical drugs for herpesvirus exhibit high toxicity and suffer from significant drug resistance. The development of new, effective, and safe anti-herpesvirus agents with different mechanisms of action is greatly required. Objective: Novel inhibitors against herpesvirus with different mechanisms of action from that of clinical drugs. Methods: A series of novel 5-(benzylamino)-1H-1,2,3-triazole-4-carboxamides were efficiently synthesized and EC50 values against Human Cytomegalovirus (HCMV), Varicella-Zoster Virus (VZV) and Herpes Simplex Virus (HSV) were evaluated in vitro. Results:

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13

Andronova, V. L. "MODERN ETHIOTROPIC CHEMOTHERAPY OF HERPESVIRUS INFECTIONS: ADVANCES, NEW TRENDS AND PERSPECTIVES. ALPHAHERPESVIRUSES (PART II)." Problems of Virology, Russian journal 63, no. 4 (2018): 149–59. http://dx.doi.org/10.18821/0507-4088-2018-63-4-149-159.

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A key role in the treatment of herpesviral infections is played by modified nucleosides and their predecessors - acyclovir, its L-valine ester (valaciclovir) and famciclovir (prodrug of penciclovir). The biological activity of compounds of this class is determined by their similarity to natural nucleosides. After phosphorylation by viral thymidine kinase and then cell enzymes to the triphosphate forms, acyclovir and penciclovir inhibit the activity of viral DNA polymerase and synthesis of viral DNA. The increasing role of herpesvirus infections in human infectious pathology, as well as the dev

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14

Krown, Susan E., Dirk P. Dittmer, and Ethel Cesarman. "Pilot Study of Oral Valganciclovir Therapy in Patients With Classic Kaposi Sarcoma." Journal of Infectious Diseases 203, no. 8 (2011): 1082–86. http://dx.doi.org/10.1093/infdis/jiq177.

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AbstractWe conducted a clinical trial of oral valganciclovir, a drug with in vitro activity against Kaposi sarcoma (KS)–associated herpesvirus (KSHV), in classic KS. Five human immunodeficiency virus–seronegative participants received valganciclovir for up to six 4-week cycles at doses used for cytomegalovirus infection. None of the study subjects showed an objective response; KS progressed in 4 subjects after 1–4 cycles and remained stable in 1 subject after 6 cycles. KS biopsies showed minimal lytic KSHV antigen and gene expression at baseline and no treatment-associated changes. Although va

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15

McGeoch, Duncan J. "Molecular evolution of the γ–Herpesvirinae". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, № 1408 (2001): 421–35. http://dx.doi.org/10.1098/rstb.2000.0775.

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Genomic sequences available for members of the γ– Herpesvirinae allow analysis of many aspects of the group's evolution. This paper examines four topics: (i) the phylogeny of the group; (ii) the histories of γ–herpesvirus–specific genes; (iii) genomic variation of human herpesvirus 8 (HHV–8); and (iv) the relationship between Epstein–Barr virus types 1 and 2 (EBV–1 and EBV–2). A phylogenetic tree based on eight conserved genes has been constructed for eight γ–herpesviruses and extended to 14 species with smaller gene sets. This gave a generally robust assignment of evolutionary relationships,

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16

Pashinyan, Albina G., L. I. Ilienko, A. N. Akopyan, and D. G. Dzhavaeva. "THE FEATURES OF THE CLINICAL MANIFESTATIONS OF THE VIRAL EXANTHEMA." Russian Journal of Skin and Venereal Diseases 20, no. 4 (2017): 205–8. http://dx.doi.org/10.18821/1560-9588-2017-20-4-205-208.

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Currently there are about 200 different studied herpes viruses, only 8 types are pathogenic for humans. They all belong to the family Herpesviridae, which according to the structure of the virion and biological properties is divided into three subfamilies: α, β, and γ. Human herpesvirus 6B belongs to the subfamily of β-herpesvirus, genus Roseolovirus. The overview of current information on the etiology, epidemiology, clinical manifestations of infection caused by human herpesvirus 6B is presented. The diagnosis of the viral exanthema using modern laboratory technology is considered.

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17

Rybalkina, T. N., N. V. Karazhas, M. Y. Lysenkova, et al. "Formation of foci of herpesvirus infections in families." Infekcionnye bolezni 18, no. 3 (2020): 119–25. http://dx.doi.org/10.20953/1729-9225-2020-3-119-125.

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Objective. To analyze circulation of herpes simplex virus (HSV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus type six (HHV-6) within families, to evaluate the conditions of formation of family foci, and to identify possible sources of infection. Patients and methods. We examined 124 families, including 11 two-parent families (mother, father, and child) and 108 oneparent families (mother and child). Five families had a mother and two children. Antibodies of various classes against herpesviruses were detected using enzyme-linked immunosorbent assay (ELISA). Herpesviru

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18

IRVING, W. L. "Human herpesvirus-6." Journal of Medical Microbiology 36, no. 4 (1992): 221–22. http://dx.doi.org/10.1099/00222615-36-4-221.

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19

Enbom, Malin, Fu-Zhang Wang, Sten Fredrikson, Claes Martin, Helena Dahl, and Annika Linde. "Similar Humoral and Cellular Immunological Reactivities to Human Herpesvirus 6 in Patients with Multiple Sclerosis and Controls." Clinical Diagnostic Laboratory Immunology 6, no. 4 (1999): 545–49. http://dx.doi.org/10.1128/cdli.6.4.545-549.1999.

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ABSTRACT Several studies have suggested an association between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS). We have previously studied intrathecal production of antibody to lymphotropic herpesviruses in MS patients and the presence of human herpesvirus 1 to 7 DNAs in cerebrospinal fluid (CSF). In the present study anti-HHV-6 immunoglobulin M (IgM) in serum and anti-HHV-6 IgG subclasses in serum and CSF were examined and the lymphoproliferative response to HHV-6 was analyzed. The PCR examination was refined by purifying DNA from CSF and retesting the samples for HHV-6 DNA. There wer

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20

Egyed, László. "Replication of Bovine Herpesvirus Type 4 in Human Cells In Vitro." Journal of Clinical Microbiology 36, no. 7 (1998): 2109–11. http://dx.doi.org/10.1128/jcm.36.7.2109-2111.1998.

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A reference strain (Movár 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung cell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detected a 10,000-times-higher level of BHV-4 DNA. Titration of the supernatant indicated a 100-fold increase of infectious particles. Since this is the first bovine (human herpesvirus 8 and Epstein-Barr vir

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21

Thomsen, Darrell R., Nancee L. Oien, Todd A. Hopkins, et al. "Amino Acid Changes within Conserved Region III of the Herpes Simplex Virus and Human Cytomegalovirus DNA Polymerases Confer Resistance to 4-Oxo-Dihydroquinolines, a Novel Class of Herpesvirus Antiviral Agents." Journal of Virology 77, no. 3 (2003): 1868–76. http://dx.doi.org/10.1128/jvi.77.3.1868-1876.2003.

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ABSTRACT The 4-oxo-dihydroquinolines (PNU-182171 and PNU-183792) are nonnucleoside inhibitors of herpesvirus polymerases (R. J. Brideau et al., Antiviral Res. 54:19-28, 2002; N. L. Oien et al., Antimicrob. Agents Chemother. 46:724-730, 2002). In cell culture these compounds inhibit herpes simplex virus type 1 (HSV-1), HSV-2, human cytomegalovirus (HCMV), varicella-zoster virus (VZV), and human herpesvirus 8 (HHV-8) replication. HSV-1 and HSV-2 mutants resistant to these drugs were isolated and the resistance mutation was mapped to the DNA polymerase gene. Drug resistance correlated with a poin

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22

Xue, Tianjiao, Huan Ye, Fang Li, et al. "A case of abdominal-pelvic infiltrative lesion of chronic active Epstein–Barr virus infection." European Journal of Inflammation 18 (January 2020): 205873922093688. http://dx.doi.org/10.1177/2058739220936889.

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Epstein–Barr virus (EBV) belongs to a subfamily of herpesviruses, also known as human herpesvirus type 4. EBV is widely distributed in the population, with a high infection rate of 90%. EBV infects mainly B lymphocytes, stimulates cell proliferation and transformation and even causes cancer. In recent years, it has been found that it can also infect T lymphocytes, epithelial cells and natural killer (NK) cells and can cause related diseases. EBV infection can cause a variety of clinical symptoms and clinical manifestations, which brings some confusion to clinical diagnosis and easily leads to

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23

Latif, Muhammad Bilal, Bénédicte Machiels, Xue Xiao, Jan Mast, Alain Vanderplasschen, and Laurent Gillet. "Deletion of Murid Herpesvirus 4 ORF63 Affects the Trafficking of Incoming Capsids toward the Nucleus." Journal of Virology 90, no. 5 (2015): 2455–72. http://dx.doi.org/10.1128/jvi.02942-15.

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ABSTRACTGammaherpesviruses are important human and animal pathogens. Despite the fact that they display the classical architecture of herpesviruses, the function of most of their structural proteins is still poorly defined. This is especially true for tegument proteins. Interestingly, a potential role in immune evasion has recently been proposed for the tegument protein encoded by Kaposi's sarcoma-associated herpesvirus open reading frame 63 (ORF63). To gain insight about the roles of ORF63 in the life cycle of a gammaherpesvirus, we generated null mutations in the ORF63 gene of murid herpesvi

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24

Ongrádi, József, Valéria Kövesdi, and Enikő Kováts. "Human herpesvirus 7." Orvosi Hetilap 151, no. 16 (2010): 645–51. http://dx.doi.org/10.1556/oh.2010.28856.

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Az emberi 7-es herpeszvírus 1990 óta ismert, közeli rokonságban áll a 6-os herpeszvírussal, annak B változatával. Csak emberi sejtekben szaporodik, receptora a CD4 molekula. A fertőzött sejtek egy részében élethossziglan lappang, gyakran reaktiválódik és a nyálban tünetmentesen ürül. Gyermekek egy része 3–4 éves korára tünetmentesen fertőződik, de minden életkorban találhatók szeronegatív egyének, akik fogékonyak a fertőzés iránt. Gyermekekben ritkán exanthema subitum, múló lázas-görcsös állapotok, fiatal felnőttekben rózsahámlás, immunszuppresszált egyénekben a reaktiválódott 6-os B herpeszví

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25

Stevenson, Linda, and Dawn Sabrina Brooke. "Roseola (human herpesvirus 6)." Journal of Pediatric Health Care 8, no. 6 (1994): 283. http://dx.doi.org/10.1016/0891-5245(94)90012-4.

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26

Dęborska, D., M. Durlik, A. Sadowska, et al. "Human herpesvirus-6 and human herpesvirus-8 seroprevalence in kidney transplant recipients." Transplantation Proceedings 34, no. 2 (2002): 673–74. http://dx.doi.org/10.1016/s0041-1345(01)02883-4.

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27

Vikulov, G. Kh, E. A. Domonova, E. V. Melekhina, О. Yu Silveystrova, and К. V. Кuleshov. "Inherited chromosomally integrated Human herpesvirus 6B in a woman with herpesvirus infection and secondary immune deficiency." Infekcionnye bolezni 18, no. 4 (2020): 182–88. http://dx.doi.org/10.20953/1729-9225-2020-4-182-188.

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In this article, we discuss some aspects of investigating characteristics of infections caused by Human betaherpesvirus 6A/B (HHV-6A/B) and report a case of laboratory confirmed chromosomally integrated HHV-6B (iciHHV-6B) in a 35-year-old woman with herpesvirus infection and secondary immunodeficiency of unknown origin. We have also described an algorithm for the diagnosis and management of patients with positive iciHHV-6A/B status. Key words: HHV-6-infection, diagnostics, human betaherpesvirus 6B, human herpesvirus 6B, chromosomal integration, inheritance, iciHHV-6B, algorithm

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28

Black, Jodi B., and Philip E. Pellett. "Human herpesvirus 7." Reviews in Medical Virology 9, no. 4 (1999): 245–62. http://dx.doi.org/10.1002/(sici)1099-1654(199910/12)9:4<245::aid-rmv253>3.0.co;2-i.

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29

Balabanova, R. M. "Rheumatic diseases and viral infection: is there an association?" Modern Rheumatology Journal 14, no. 4 (2020): 98–102. http://dx.doi.org/10.14412/1996-7012-2020-4-98-102.

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Viral infections, hepatitis B and C and herpesvirus-induced infections in particular, are widespread in the population. Recent years have seen the emergence of new viral infections that were previously endemic. Understanding the role of viruses in the pathogenesis of rheumatic diseases (RDs) is of great importance. First, they cause the clinical manifestations characteristic of many RDs (systemic lupus erythematosus, rheumatoid arthritis, polymyositis, and Sjö gren's disease). The author discusses several possible mechanisms of the involvement of viruses in the development of autoimmune disord

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Davison, Andrew J., Benes L. Trus, Naiqian Cheng, et al. "A novel class of herpesvirus with bivalve hosts." Journal of General Virology 86, no. 1 (2005): 41–53. http://dx.doi.org/10.1099/vir.0.80382-0.

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Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of purified capsids revealed the distinctive T=16 icosahedral structure characteristic of herpesviruses, although the preparations examined lacked pentons. The gross genome organization of OsHV-1 was similar to that of certain mammalian herpesviruses (including herpes simplex virus and human cytomegalovirus), consisting of two invertible unique regions (UL, 167

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31

Alexandrova, L. A., D. G. Semizarov, A. A. Krayevsky, and R. T. Walker. "4′-Thio-5-Ethyl-2′-Deoxyuridine5′-Triphosphate (TEDUTP): Synthesis and Substrate Properties in DNA-Synthesizing Systems." Antiviral Chemistry and Chemotherapy 7, no. 5 (1996): 237–42. http://dx.doi.org/10.1177/095632029600700503.

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An efficient synthesis of the 5′-phosphate and 5′-triphosphate of a 4′-thio-2′-deoxynucleoside is described for the first time. The 5′-triphosphate of the antiherpesvirus agent 4′-thio-5-ethyl-2′-deoxyuridine (TEDU) has been shown to be a good substrate for human placental DNA polymerase α, calf thymus terminal deoxynucleotidyl transferase, and the reverse transcriptases of human immunodeficiency virus and avian myeloblastosis virus. As it is known that TEDU is a substrate only for herpesvirus-encoded thymidine kinases and not the cellular kinases, it is likely that the utilization of TEDUTP b

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32

Revankar, GR, JO Ojwang, SD Mustain, et al. "Thiazolo[4,5-d]Pyrimidines. Part II. Synthesis and Anti-Human Cytomegalovirus Activity in Vitro of Certain Acyclonucleosides and Acyclonucleotides Derived from the Guanine Analogue 5-Aminothiazolo[4,5-d]Pyrimidine-2,7(3H,6H)-Dione." Antiviral Chemistry and Chemotherapy 9, no. 1 (1998): 53–63. http://dx.doi.org/10.1177/095632029800900102.

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The synthesis and in vitro antiviral activity of certain hydroxyalkoxymethyl, hydroxyalkyl, hydroxyalkenyl and phosphonoalkenyl derivatives of the guanine congener 5-aminothiazolo-[4,5- d]pyrimidine-2,7(3 H,6 H)-dione are reported. The compounds of this study were selected for their structural similarity to acyclonucleosides with known anti-herpesvirus activity. 5-Amino-3-[(Z)-4-hydroxy-2-buten-1-yl]thiazolo[4,5- d]pyrimidine-2,7(3 H,6 H)-dione was the only member of the series to display significant in vitro activity against human cytomegalovirus (HCMV); however, this compound did not inhibit

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33

Krueger, GerhardR F. "HUMAN HERPESVIRUS-6 INFECTION AND DISEASE." Lancet 332, no. 8609 (1988): 518. http://dx.doi.org/10.1016/s0140-6736(88)90175-4.

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34

Asano, Yoshizo, Tetsushi Yoshikawa, Sadao Suga, et al. "HUMAN HERPESVIRUS 6 HARBOURING IN KIDNEY." Lancet 334, no. 8676 (1989): 1391. http://dx.doi.org/10.1016/s0140-6736(89)91993-4.

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35

Messick, Troy E., Lois Tolvinski, Edward R. Zartler, et al. "Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA." Molecules 25, no. 7 (2020): 1760. http://dx.doi.org/10.3390/molecules25071760.

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The human gamma-herpesviruses Epstein–Barr virus (EBV) (HHV-4) and Kaposi’s sarcoma-associated herpesvirus (KSHV) (HHV-8) are responsible for a number of diseases, including various types of cancer. Epstein–Barr nuclear antigen 1 (EBNA1) from EBV and latency-associated nuclear antigen (LANA) from KSHV are viral-encoded DNA-binding proteins that are essential for the replication and maintenance of their respective viral genomes during latent, oncogenic infection. As such, EBNA1 and LANA are attractive targets for the development of small-molecule inhibitors. To this end, we performed a biophysi

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Goldsmith, C. S., D. Burns, P. E. Pellett, S. R. Zaki, and J. B. Black. "Ultrastructure of human herpesvirus 7." Proceedings, annual meeting, Electron Microscopy Society of America 53 (August 13, 1995): 1032–33. http://dx.doi.org/10.1017/s0424820100141536.

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Human herpesvirus 7 (HHV-7) was originally isolated in 1989 from the peripheral blood lymphocytes of a healthy individual. Most children between 2 and 5 years of age develop antibodies against HHV-7, and the virus has recently been implicated as the causative agent in secondary episodes of the childhood disease roseola infantum. Approximately 90% of the general population is seropositive, and virus can be isolated from the saliva of up to 75% of healthy adults. This study describes the ultrastructural growth properties of an HHV-7 isolate obtained from a saliva specimen.Cord blood lymphocytes

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Kovalyk, V. P., M. A. Gomberg, E. E. Bragina, K. I. Yurlov, and A. A. Kushch. "Herpesvirus role in male infertility." Russian Medical Inquiry 5, no. 3 (2021): 123–29. http://dx.doi.org/10.32364/2587-6821-2021-5-3-123-129.

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Nowadays, the search for etiopathogenetic factors of infertility is an urgent medical and social task. 23 men with chronic abacterial prostatitis in a barren marriage underwent the follow-up. Herpesviruses of types IV–VI were detected in urogenital samples (urethra, ejaculate, prostate secretions) in 8 of 23 men who were treated with valacyclovir (500 mg 2 times a day for 3 months) and interferon α-2b in combination with antioxidants — vitamins E and C (rectal suppositories). Based on the personal experience of the authors, the patients were prescribed the following drug use regimen: 3 million

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Ashshi, A. "Detection of human cytomegalovirus, human herpesvirus type 6 and human herpesvirus type 7 in urine specimens by multiplex PCR." Journal of Infection 47, no. 1 (2003): 59–64. http://dx.doi.org/10.1016/s0163-4453(03)00057-4.

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Asada, Hideo, Vera Klaus-Kovtun, Hana Golding, Stephen I. Katz, and Andrew Blauvelt. "Human Herpesvirus 6 Infects Dendritic Cells and Suppresses Human Immunodeficiency Virus Type 1 Replication in Coinfected Cultures." Journal of Virology 73, no. 5 (1999): 4019–28. http://dx.doi.org/10.1128/jvi.73.5.4019-4028.1999.

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ABSTRACT Human herpesvirus 6 (HHV-6) has been implicated as a cofactor in the progressive loss of CD4+ T cells observed in AIDS patients. Because dendritic cells (DC) play an important role in the immunopathogenesis of human immunodeficiency virus (HIV) disease, we studied the infection of DC by HHV-6 and coinfection of DC by HHV-6 and HIV. Purified immature DC (derived from adherent peripheral blood mononuclear cells in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4) could be infected with HHV-6, as determined by PCR analyses, intracellular monoclonal antib

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Millichap, J. Gordon. "Human Herpesvirus-6 and Roseola Infantum Meningitis." Pediatric Neurology Briefs 6, no. 4 (1992): 26. http://dx.doi.org/10.15844/pedneurbriefs-6-4-2.

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Zimmermann, Wolfgang, Hermann Broll, Bernhard Ehlers, Hans-Jörg Buhk, André Rosenthal, and Michael Goltz. "Genome Sequence of Bovine Herpesvirus 4, a Bovine Rhadinovirus, and Identification of an Origin of DNA Replication." Journal of Virology 75, no. 3 (2001): 1186–94. http://dx.doi.org/10.1128/jvi.75.3.1186-1194.2001.

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ABSTRACT Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus of cattle. The complete long unique coding region (LUR) of BoHV-4 strain 66-p-347 was determined by a shotgun approach. Together with the previously published noncoding terminal repeats, the entire genome sequence of BoHV-4 is now available. The LUR consists of 108,873 bp with an overall G+C content of 41.4%. At least 79 open reading frames (ORFs) are present in this coding region, 17 of them unique to BoHV-4. In contrast to herpesvirus saimiri and human herpesvirus 8, BoHV-4 has a reduced set of ORFs homologous to cellular genes. Ge

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Maeki, Takahiro, and Yasuko Mori. "Features of Human Herpesvirus-6A and -6B Entry." Advances in Virology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/384069.

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Human herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to theBetaherpesvirinaesubfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species. The process of herpesvirus entry into target cells is complicated, and in the case of HHV-6A and HHV-6B, the detailed mechanism remains to be elucidated, although both viruses are known to enter cells via endocytosis. In this paper, (1) findings about the cellular receptor and its ligand for HHV-6A and HHV-6B are summarized, and (2) a schematic mod

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Taras, T. M., E. R. Luchkevich, V. I. Shupeniuk, O. P. Sabadakh, L. D. Bolibrukh, and L. R. Zhurakhivska. "Synthesis and predicted antiviral activity of 4-substituted 9,10-anthraquinone derivatives." Chemistry, Technology and Application of Substances 3, no. 2 (2020): 67–72. http://dx.doi.org/10.23939/ctas2020.02.067.

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Antiviral activity was predicted by using data from program PASS Online for synthesized compounds against picornavirus, the influenza and the rhinovirus, what fits in today's strategy of creating of the anthraquinone-based anticancer drugs and with antibacterial effect. There are several current methods to synthesize 9,10-anthraquinone, which contain the biogenic amines in the 4-position. Antiviral activity was predicted by using program AVCpred in a percentage of inhibition against deadly viruses like Human immunodeficiency virus (HIV), Hepatitis C virus (HCV), Hepatitis B virus (HBV), Human

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Roa-Linares, Vicky, Yaneth Miranda-Brand, Verónica Tangarife-Castaño, et al. "Anti-Herpetic, Anti-Dengue and Antineoplastic Activities of Simple and Heterocycle-Fused Derivatives of Terpenyl-1,4-Naphthoquinone and 1,4-Anthraquinone." Molecules 24, no. 7 (2019): 1279. http://dx.doi.org/10.3390/molecules24071279.

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Quinones are secondary metabolites of higher plants associated with many biological activities, including antiviral effects and cytotoxicity. In this study, the anti-herpetic and anti-dengue evaluation of 27 terpenyl-1,4-naphthoquinone (NQ), 1,4-anthraquinone (AQ) and heterocycle-fused quinone (HetQ) derivatives was done in vitro against Human Herpesvirus (HHV) type 1 and 2, and Dengue virus serotype 2 (DENV-2). The cytotoxicity on HeLa and Jurkat tumor cell lines was also tested. Using plaque forming unit assays, cell viability assays and molecular docking, we found that NQ 4 was the best ant

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Brown, NathanielA, CiroV Sumaya, Chun-Ren Liu, et al. "FALL IN HUMAN HERPESVIRUS 6 SEROPOSITIVITY WITH AGE." Lancet 332, no. 8607 (1988): 396. http://dx.doi.org/10.1016/s0140-6736(88)92864-4.

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Huang, Li-Min, Chin-Yun Lee, Kai-Hsin Lin, et al. "Human herpesvirus-6 associated with fatal haemophagocytic syndrome." Lancet 336, no. 8706 (1990): 60–61. http://dx.doi.org/10.1016/0140-6736(90)91580-4.

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Neyts, J., and E. De Clercq. "Antiviral drug susceptibility of human herpesvirus 8." Antimicrobial Agents and Chemotherapy 41, no. 12 (1997): 2754–56. http://dx.doi.org/10.1128/aac.41.12.2754.

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We studied the susceptibility of human herpesvirus 8 (HHV-8) to a number of antiherpesvirus agents. The acyclic nucleoside phosphonate (ANP) analogs cidofovir and HPMPA [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine] effected potent inhibition of HHV-8 DNA synthesis, with 50% effective concentrations (EC50) of 6.3 and 0.6 microM, respectively. Adefovir, an ANP with both antiretrovirus and antiherpesvirus activity, blocked HHV-8 DNA replication at a fourfold-lower concentration than did foscarnet (EC50 of 39 and 177 microM, respectively). The most potent inhibitory effect was obtained with

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Cloutier, N., O. van Eyll, M. E. Janelle, S. Lefort, S. J. Gao, and L. Flamand. "Increased tumorigenicity of cells carrying recombinant human herpesvirus 8." Archives of Virology 153, no. 1 (2007): 93–103. http://dx.doi.org/10.1007/s00705-007-1072-4.

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Machiels, Bénédicte, Laurent Gillet, Sieberth Do Nascimento Brito, et al. "Natural antibody–complement dependent neutralization of bovine herpesvirus 4 by human serum." Microbes and Infection 9, no. 14-15 (2007): 1530–37. http://dx.doi.org/10.1016/j.micinf.2007.08.007.

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Isaacson, E., C. A. Glaser, B. Forghani, et al. "Evidence of Human Herpesvirus 6 Infection in 4 Immunocompetent Patients with Encephalitis." Clinical Infectious Diseases 40, no. 6 (2005): 890–93. http://dx.doi.org/10.1086/427944.

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