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Journal articles on the topic 'HETA'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Sufrin, Janice R., Arthur J. Spiess, Canio J. Marasco, Donna Rattendi, and Cyrus J. Bacchi. "Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine." Antimicrobial Agents and Chemotherapy 52, no. 1 (October 22, 2007): 211–19. http://dx.doi.org/10.1128/aac.00480-07.

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ABSTRACT The purine nucleoside 5′-deoxy-5′-(hydroxyethylthio)-adenosine (HETA) is an analog of the polyamine pathway metabolite 5′-deoxy-5′-(methylthio)-adenosine (MTA). HETA is a lead structure for the ongoing development of selectively targeted trypanocidal agents. Thirteen novel HETA analogs were synthesized and examined for their in vitro trypanocidal activities against bloodstream forms of Trypanosoma brucei brucei LAB 110 EATRO and at least one drug-resistant Trypanosoma brucei rhodesiense clinical isolate. New compounds were also assessed in a cell-free assay for their activities as substrates of trypanosome MTA phosphorylase. The most potent analog in this group was 5′-deoxy-5′-(hydroxyethylthio)-tubercidin, whose in vitro cytotoxicity (50% inhibitory concentration [IC50], 10 nM) is 45 times greater than that of HETA (IC50, 450 nM) against pentamidine-resistant clinical isolate KETRI 269. Structure-activity analyses indicate that the enzymatic cleavage of HETA analogs by trypanosome MTA phosphorylase is not an absolute requirement for trypanocidal activity. This suggests that additional biochemical mechanisms are associated with the trypanocidal effects of HETA and its analogs.

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2

Bacchi, C. J., K. Sanabria, A. J. Spiess, M. Vargas, C. J. Marasco, L. M. Jimenez, B. Goldberg, and J. R. Sufrin. "In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides." Antimicrobial Agents and Chemotherapy 41, no. 10 (October 1997): 2108–12. http://dx.doi.org/10.1128/aac.41.10.2108.

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5'-Deoxy-5'-(methylthio)adenosine (MTA), a key by-product of polyamine biosynthesis, is cleaved by MTA phosphorylase and is salvaged as adenine and, through conversion of the ribose moiety, methionine. An analog of MTA, 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA), is a substrate for trypanosome MTA phosphorylase and is active in vitro and in vivo against Trypanosoma brucei brucei, an agent of bovine trypanosomiasis. In this study, HETA and three O-acylated HETA derivatives were examined for their activities against model infections of T. b. brucei and Trypanosoma brucei rhodesiense, the agent of East African sleeping sickness. HETA was curative (>60%) for infections caused by 5 of 11 clinical isolates of T. b. rhodesiense when it was given to mice at 200 mg/kg of body weight for 7 days as a continuous infusion in osmotic pumps. HETA at 150 to 200 mg/kg also extended the life spans of the mice infected with four additional isolates two- to fivefold. Di- and tri-O-acetylated derivatives of HETA also proved curative for the infections, while a tri-O-propionyl derivative, although also curative, was not as effective. This study indicates that substrate analogs of MTA should be given important consideration for development as novel chemotherapies against African trypanosomiasis.

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3

Adeyemi, Olufunmilayo O., Ismail O. Ishola, Elizabeth T. Adesanya, and Destiny O. Alohan. "Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract." Journal of Basic and Clinical Physiology and Pharmacology 30, no. 2 (October 17, 2018): 173–84. http://dx.doi.org/10.1515/jbcpp-2016-0190.

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Abstract Background Tetracera alnifolia Willd. (Dilleniaceae) is used in traditional African Medicine for the treatment of headache, abdominal pain, and rheumatism. Hence, this study sought to investigate the antinociceptive and anti-inflammatory effects of the hydroethanolic leaf extract of T. alnifolia (HeTA) in rodents. Methods Antinociceptive activity was evaluated using the acetic acid-induced writhing, formalin-/capsaicin-induced paw licking and hot plate tests in mice. The contribution of opioidergic, l-arginine-nitric oxide, and ATP-sensitive potassium channel pathways in HeTA-induced antinociception was also evaluated. The anti-inflammatory effect was assessed using the carrageenan-induced paw edema, xylene ear edema, cotton pellet granuloma, and complete Freund’s adjuvant (CFA)-induced arthritis in rats. Results HeTA (100, 200, and 400 mg/kg, p.o.) produced significant (p<0.05) decrease in mean number of acetic acid-induced writhing, time spent licking paw in formalin, and capsaicin tests as well as time course increase in nociceptive reaction latency in hot plate test. HeTA-induced antinociception was prevented by pretreatment of mice with naloxone (non-selective opioid receptor antagonist), l-arginine (nitric oxide precursor), or glibenclamide (ATP-sensitive potassium channel blocker). HeTA (100 mg/kg, p.o.) produced a significant anti-inflammatory effect against carrageenan-induced rat paw edema (1–5 h), xylene-induced ear edema, cotton pellet-induced granuloma formation, and CFA-induced arthritis in rats. The effects of HeTA in various models were similar to the effect of the standard reference drugs. Conclusions Findings from this study showed that HeTA possesses antinociceptive effect possibly mediated through peripheral opioid receptors with activation of l-arginine-nitric oxide and ATP-sensitive potassium channel pathway as well as anti-inflammatory activity.

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4

Bracht, Hendrik, Peter Radermacher, Michael Georgieff, and Wolfgang Stahl. "Heta, hexa, penta, tetra-starches." Critical Care Medicine 40, no. 2 (February 2012): 683–85. http://dx.doi.org/10.1097/ccm.0b013e318232d033.

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5

Troczynski, T., Steve CockCroft, and H. Wong. "Thermal Barrier Coatings for Heta Engines." Key Engineering Materials 122-124 (September 1996): 451–62. http://dx.doi.org/10.4028/www.scientific.net/kem.122-124.451.

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6

EMİNOĞLU, Nevzat. "Medreseyên Kurdan Ji Destpêkê Heta Îro." Anemon Muş Alparslan Üniversitesi Sosyal Bilimler Dergisi 3, no. 2 (November 23, 2015): 197. http://dx.doi.org/10.18506/anemon.41955.

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7

Azambuja, Mauricio Altieri, Jurgen Becker, and Fernanda Lima Kastensmidt. "HETA: Hybrid Error-Detection Technique Using Assertions." IEEE Transactions on Nuclear Science 60, no. 4 (August 2013): 2805–12. http://dx.doi.org/10.1109/tns.2013.2246798.

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8

Frei, Jiří. "Implementation of Harmonised European Transition Altitude (HETA)." MAD - Magazine of Aviation Development 4, no. 19 (July 15, 2016): 5. http://dx.doi.org/10.14311/mad.2016.19.01.

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<span style="font-family: 'Times New Roman',serif; font-size: 10pt; mso-fareast-font-family: 'MS Mincho'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US">Since 2010 there has been a noticeable effort to implement harmonized European transition altitude (HETA). This effort resulted in establishing of several working groups. As outputs were proposed three options but no mandatory implementation rules for European countries (resp. air navigation services providers). Nowadays each country evaluates impacts of implementation of one of three proposed solutions and some countries even implement kind of harmonized transition altitude in cooperation with neighboring countries (Slovakia, Hungary and Austria). This article briefly describes the general problem in section I and II. Impacts of all three proposed options by working group on involved subjects such as crew, controllers, but also environment or safety are evaluated. The end of the article describes in details the way of implementation in Slovakia and some case studies related to </span><span style="font-family: 'Times New Roman',serif; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US">altimeter setting rules in the area of common interest at the interface between FIR Prague, Bratislava and Vienna</span><span style="font-family: 'Times New Roman',serif; font-size: 10pt; mso-fareast-font-family: 'MS Mincho'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US">.</span>

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9

KESKIN, Assistant Prof Dr Necat. "JI SED SAL BERÊ HETA NIHA: HESTÊN NETEWÎ Û SIYASETA KURDAN." Journal of Zankoy Sulaimani Part (B - for Humanities) 19, no. 3 (January 30, 2000): 767–82. http://dx.doi.org/10.17656/jzsb.10643.

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10

Helle, Anna, Heta Marttinen, and Jarkko Toikkanen. "Arvostelut." AVAIN - Kirjallisuudentutkimuksen aikakauslehti, no. 2 (June 1, 2014): 87–94. http://dx.doi.org/10.30665/av.74950.

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Anna Helle Nykykirjallisuutemme kirjallisuushistoriallinen kartoitus Mika Hallila, Yrjö Hosiaisluoma, Sanna Karkulehto, Leena Kirstinä & Jussi Ojajärvi (toim.): Suomen nykykirjallisuus 1–2. Heta Marttinen Perinnetietoisesti perinteitä vastaan Tuva Korsström: Från Lexå till Glitterscenen. Finlandssvenska tidsbilder, läsningar, författarporträtt 1960–2013. Jarkko Toikkanen Allegorian ratkaisut Pirjo Lyytikäinen: Leena Krohn ja allegorian kaupungit.

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11

Kaisto, Heta, and Katja Lautamatti. "Satavuotias yö: Radioteos sisällissodan muistitietoarkistoista." Lähikuva – audiovisuaalisen kulttuurin tieteellinen julkaisu 31, no. 1 (May 21, 2018): 64–72. http://dx.doi.org/10.23994/lk.70452.

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Aalto-yliopiston tohtoriopiskelijat Heta Kaisto ja Katja Lautamatti tekivät radioteoksen ”Satavuotias yö” (2018), joka julkaistiin Yle Radio 1:n Radio Variaatiossa sunnuntaina 6.5.2018. Radioteos on molempien väitöstutkimusten taiteellinen osuus. Teos on osa laajempaa monialaista Koneen säätiön rahoittamaa hanketta ”Hysteeriset oireet – Suomen sisällissodan ylimääräiset liuskat”, jossa tutkitaan taiteen ja journalismin keinoin sisällissodan arkistoja.

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12

Sipka, Timothy A. "Proof without Words: Law of Cosines for $ heta < \pi/2$." Mathematics Magazine 61, no. 4 (October 1, 1988): 259. http://dx.doi.org/10.2307/2689363.

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13

Preda, A., L. L. Popescu, and R. S. Popescu. "Numerical calculation of a sea water heta exchanger using Simulink softwear." IOP Conference Series: Materials Science and Engineering 227 (August 2017): 012104. http://dx.doi.org/10.1088/1757-899x/227/1/012104.

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14

Lonoff. "Bluebeard Gothic: Jane Eyre and Its Progeny, by Heta Pyrhönen." Victorian Studies 54, no. 2 (2012): 330. http://dx.doi.org/10.2979/victorianstudies.54.2.330.

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15

Rothermund, Lars, Susanne Luckert, Peter Kossmehl, Hans H. Neumayer, Martin Paul, and Reinhold Kreutz. "Renal HETA/ETB Receptor Disbalance Characterizes Progression to Salt Sensitive Malignant Hypertension in Spontaneous Hypertension." Hypertension 36, suppl_1 (October 2000): 711. http://dx.doi.org/10.1161/hyp.36.suppl_1.711-e.

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P99 It is unclear why a subgroup of patients with essential hypertension develop salt sensitive hypertension with progression to malignant hypertension and renal failure. We evaluated the role of the renal endothelin (ET)-system in this setting by investigating two animal models with either salt-resistant or salt sensitive spontaneous hypertension. We studied salt resistant spontaneously hypertensive rats (SHR) and salt sensitive stroke-prone spontaneously hypertensive rats (SHRSP) after either sham operation on a normal diet (Sham) or after unilateral nephrectomy and high NaCl loading (NX-NaCl) with 4% NaCl in diet for 6 weeks (n=10, respectively). Systolic blood pressure (SBP) increased only in SHRSP-NX-NaCl compared to SHRSP-Sham (250±6 vs. 172±5 mmHg, p<0.0001) while SBP remained unchanged in SHR-NX-NaCl compared to SHR-Sham. Albuminuria increased 210-fold in SHRSP-NX-NaCl compared to SHRSP-Sham (p<0.0001), but no significant change was observed in SHR-NX-NaCl. In SHRSP-NX-NaCl glomerulosclerosis index, tubulointerstitial damage index, renal ET-1 mRNA expression, and urinary ET-1 excretion were significantly elevated compared to SHRSP (p<0.05, respectively), but no significant changes of these parameters were found in SHR after NX-NaCl. Urinary sodium excretion (U Na ) increased in both SHR and SHRSP after NX-NaCl, but U Na was significantly reduced by 60% in SHRSP-NX-NaCl compared to SHR-NX-NaCl (p<0.0001). After NX-NaCl renal ETA and ETB receptor densities, obtained by Scatchard analyses, were elevated in both SHR and SHRSP (ETA: 2.2- and 4.7-fold, ETB: 2.2- and 2.4-fold, p<0.05 respectively). However, ETA increase was significantly more pronounced in SHRSP-NX-NaCl, thus resulting in an 2.1-fold increase of ETA/ETB receptor ratio in SHRSP-NX-NaCl. We conclude that activation of the renal ET system in conjunction with an increased ETA/ETB receptor ratio may contribute to decreased U Na and higher susceptibility for the development malignant hypertension and kidney damage in salt sensitive spontaneous hypertension.

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16

Trop, M., E. J. Schiffrin, R. Callahan, and E. A. Carter. "Effect of heta-starch colloidal solutions on reticuloendothelial phagocytic system (RES) function in burned and infected rats." Burns 18, no. 6 (December 1992): 463–65. http://dx.doi.org/10.1016/0305-4179(92)90178-w.

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17

Holland, D., and C. P. Wolk. "Identification and characterization of hetA, a gene that acts early in the process of morphological differentiation of heterocysts." Journal of Bacteriology 172, no. 6 (1990): 3131–37. http://dx.doi.org/10.1128/jb.172.6.3131-3137.1990.

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18

Lesser, H. "Individual Liberty and Medical Control: Heta Hayry, Avebury Series in Philosophy, Ashgate, Aldershot, 1998, vi+102 pages, pound29.95." Journal of Medical Ethics 27, no. 3 (June 1, 2001): 207–8. http://dx.doi.org/10.1136/jme.27.3.207.

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19

Festino, Cielo. "Grinding Songs from Goa." Aletria: Revista de Estudos de Literatura 31, no. 1 (March 31, 2021): 225–46. http://dx.doi.org/10.35699/2317-2096.2021.25541.

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The aim of this paper is to bring an analysis of oviyos, folkloric songs that Indian women from the Hindu community of Goa, former Portuguese colony in India used to sing while working at the grinding stone. These songs, a sample of Goan folklore, were collected by Heta Pandit in the book Grinding Stories. Songs from Goa (2018), based on her field work with singers Subhadra Arjun Gaus, Saraswati, Dutta Sawant and Sarojini Bhiva Gaonkar. The songs, sung in a dialect of Marathi-Konkani, were transcribed into English. These elaborate songs are of psychological and social significance as they provide a release from a sometimes harsh reality, at the same time they are an invaluable cultural document. They have been analyzed from the perspective of Goan folklore as discussed by Phaldesai (2011), the meaning of folkloric narratives (Dundes, 2007) and a reflection on the genre oviyos (Jassal, 2012).

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20

Imran, DrSheikh, DrSampathila Padmanabha, DrHabeeb Rehman, and Dr Ayaskant Sahoo. "A Comparative Study Of Preloading Efficacy Of Ringer’s Lactate V/S 6% Heta Starch Solutions In Preventing Hypotensionfollowing Spinal Anaesthesia." IOSR Journal of Dental and Medical Sciences 13, no. 3 (2014): 43–48. http://dx.doi.org/10.9790/0853-13324348.

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21

Gaine, Vincent M. "Raita Merivieta, Kimmo Ahonen, Heta Mulari and Rami Mähkä, eds, Frontiers of Screen History: Imagining European Borders in Cinema, 1945–2010." European History Quarterly 47, no. 2 (April 2017): 367–69. http://dx.doi.org/10.1177/0265691417695979aa.

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22

Kaplan, Yaşar. "Revolution of Sheikh Abdul Salam Barzani (1908-1914)." Humanities Journal of University of Zakho 6, no. 1 (March 30, 2018): 358. http://dx.doi.org/10.26436/2018.6.1.598.

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Malbata Barzan ya binyadê wan dîgehîte tradîsyona Neqşebendî- Xalidî, berê ji xebatên xwe yên wekî îro yên siyasî zêdetir bi xebatên îrşada ayînî cih girtibûn. Di destpêka sedsala XXan pê ve ji bilî çalakiyên xwe yên deverê yên ayînî û çandî, dest bi xebatên siyasî û polîtîk kirin. Di nava malbata Barzan da yekemîn kesê dest bi xebatên siyasî- polîtîk kirî Şêx Ebdusselam Barzanî ye. Li dor vê çendê Şêx Ebdusselam ji ragehandina Meşrûtiyeta II. heta berbanga Şerê Cîhanê yê Yekemîn li ser bizava Kurdî ya netewî gelek xebatên siyasî pêk înane. Di dema van bizavan da Şêx Ebdusselam û eşîreta Barzan ya di bin serkêşiya wî da li hemberî Dewleta Osmanî ya di bin rêveberiya Îttîhad û Tereqiyê da, hatine hemberî hev û gelek mucadele kirine. Di encama van mucadeleyan da Şêx Ebdusselam ji aliyê Dewleta Osmanî ve hatiye girtin û ji aliyê Waliyê Mûsilê Silêman Nazîfî ve li sala 1914ê li Mûsilê hatiye sêdarekirin. Di vê xebatê da di bin ronahiya belgeyên arşîvên Osmanî yên destê yekê şoreş û bizava Şêx Ebdusselam Barzanî ya digel rêveberiya Îttîhad û Tereqiyê û pêşveçûnên siyasî yên rêka sêdarekirinê jibo wî vekirî, dê bêne nirxandin.

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23

Peltonen, Jari, and Tuula Sontag-Strohm. "Genotypic differences of storage proteins in four Scandinavian spring wheat cultivars during seed development." Agricultural and Food Science 1, no. 5 (September 1, 1992): 499–507. http://dx.doi.org/10.23986/afsci.72463.

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Wheat (Triticum aestivum L.) is grown under a wide range of climatic conditions. Therefore, it is necessary to understand the underlying physiological phenomena which affect the quality of grain yield. The aim ofthis project was to study the interactions between cultivars in theiraccumulation and relative concentrations of the different protein groups of storage proteins at various stages of wheat grain development. Yield components, protein quantity and the quality of flour were examined. The study was carried out at the University of Helsinki, Department of Plant Production during 1989-1990. The cultivars used were Heta, Ruso, Reno and Kadett. Innorthern latitudes the early maturity class of a genotype is an important selection criterion associated with good breadmaking quality. The short grain filling period leads to a high rate of accumulation ofhigh molecular weight glutenins, because it coincides with a rapid expansion of the endosperm in the middle of grain filling. The associated yield loss in these cultivars may be compensated by higher number of grains per ear. Therefore, selection ofproductive wheat lines with earlymaturity, high protein concentration and high relative amount ofhigh molecular weight glutenins, and high grain number per ear instead of high kernel weight may lead to more stable yield and improved breadmaking quality.

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24

Strandén-Backa, Sofie. "Farliga vargar och bedrägliga maskhål – Produktion av risk i mediematerial om varg och barn." TRACE ∴ Journal for Human-Animal Studies 7 (April 7, 2021): 96–117. http://dx.doi.org/10.23984/fjhas.99434.

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I artikeln analyseras en diskussion om vargen och dess existensberättigande som pågick i Österbottens Tidning under år 2018 i samband med att vargar rörde sig i trakten. Utgående från Paul Slovic analyseras hur tankegångar om risk byggs upp i materialet. Syftet för artikeln är att undersöka hur varg som risk produceras och hanteras i ett tidningsmaterial, med ett särskilt fokus på de roller som barnen tilldelas. Jag intresserar mig i synnerhet för tiden, och för vad som händer med den i dessa processer. En sammansmältning av Slovics tankar om risk och Heta Lähdesmäkis och Outi Ratamäkis analys av den farliga vargen som en diskursiv resurs i det kulturella minnet i Finland ger ett underlag för en analys av ett material som i sin helhet handlar om en konstruktion av risk för vargangrepp på barn. Jag föreslår termen ”maskhål” som ett alternativ till det som Lähdesmäki och Ratamäki kallar för tidshopp, för att visa på den cirkulära rörelsen i den nutida ständiga återkomsten till händelser som man själv inte upplevt – dödliga vargangrepp på barn i äldre tid. Maskhålet ger tillgång till vargangreppen oberoende av tid och plats, och jag ser de känslor som berättelserna genererar som den kraft som upprätthåller existensen av maskhålet. I processen synliggörs även vad jag kallar för barnets inneboende moraliska imperativ.

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25

Moneir, Sarra. "Book Review: Heta Aali, Anna-Leena Perämäki and Cathleen Sarti (eds), Memory Boxes: An Experimental Approach to Cultural Transfer in History, 1500–2000." International Sociology 31, no. 5 (September 2016): 616–18. http://dx.doi.org/10.1177/0268580916655971a.

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26

Powlesland, R. G., D. J. Butler, and I. M. Westbrooke. "Was Tropical Cyclone Heta or Hunting by People Responsible for Decline of the Lupe (Ducula pacifica) (Aves: Columbidae) Population on Niue during 1994–2004?1." Pacific Science 62, no. 4 (October 2008): 461–71. http://dx.doi.org/10.2984/1534-6188(2008)62[461:wtchoh]2.0.co;2.

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27

Ilic-Spong, M., M. Spong, and R. Fischl. "The no-gain theorem and localized response for the decoupled P -<tex>heta</tex>power network with active power losses included." IEEE Transactions on Circuits and Systems 32, no. 2 (February 1985): 170–77. http://dx.doi.org/10.1109/tcs.1985.1085682.

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28

Yilmaz, Birgul. "Language Attitudes and Religion: Kurdish Alevis in the UK." Kurdish Studies 8, no. 1 (March 19, 2020): 133–61. http://dx.doi.org/10.33182/ks.v8i1.512.

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In this article, I report on results of a Matched Guise Tests (MGT) study investigating attitudes towards Bohtan (BHKr) and Maraş Kurmanji (MRKr) spoken among the UK diaspora. I focus on BHKr, which I use to refer to the Kurmanji that is identified as “good Kurmanji”, also referred to as “academic”/ “proper”, and MRKr to refer to the Kurmanji that is referred to as “bad Kurmanji” by Kurmanji speakers in the UK. The MGT, and questions pertaining to perceptual dialectology such as respondents’ perceptions of region, religion, gender and class in this study, show that attitudes towards what is perceived as BHKr and MRKr differ significantly. By concentrating on language attitudes towards Kurmanji which have never been studied in the UK context before, this paper investigates negative and positive evaluations of both BHKr and MRKr in relation to religious affiliation. Abstract In Kurmanji Helwêstên zimanî û dîn: Kurdên elewî li Ingiltereyê Di vê gotarê de encamên taqîkirineke bi rêya testa "matched guise" li ser helwêstên beramber kurmanciya Botan û ya Mereşê li nav endamên diasporaya Ingiltereyê hatine pêşkêşkirin. Her du devokên kurmanciyê yên Botan û Mereşê hatine nirxandin, ku li nav axêverên kurmanciyê li Ilgiltereyê (Yilmaz, 2018) devoka Botan li beramber "kurmanciya baş" an jî "akademîk" tê danîn û kurmanciya Mereşê jî wek "kurmanciya xerab" tê danîn. Testê û pirsyarên li ser devoknasiya sehkî (perceptual dialectology), wek seh û nezera beşdaran li ser dever, dîn, cinsiyet û çînê di vê xebatê de nîşan didin ku sehên axêveran derheq kurmanciya Botan û Mereşê bi rengekî girîng ji hev cuda ne. Bi rêya hûrbûna li ser helwêstên zimanî beramber kurmanciyê, ku heta niha qet nehatiye vekolîn li Ilgiltereyê, ev gotar berê xwe dide tehlîla nirxandinên erênî û nerênî yên li ser devokên Botan û Mereşê di warê aîdiyeta dînî de. Abstract in Sorani Hellwêstî zmanî û ayîn: 'Elewîye Kurdekan le Şanşîne Yekgirtuwekan Lem wtareda ew twêjîneweye radegeyenim ke ‏Matched Guise Testis ‎‏ ‏‎(MiGT) ‎î bo lêkollînewe le ‏hellwêstî Kurmancî ‏axêwerekanî Bohtan ‏‎(BiHKir)‎‏ we Maraş ‏‎(MiRKir) ‎‏ le naw dayesporay ‏şanşîne yekgirtuwekanda. ‏Min terkîzm xistote ser (‏‎(BiHKir‎, bo amaje dan bew kirmancaney ‏bekardênim ke be "kurmancî ‏baş" nasrawn, herweha wek "ekadîmî"/"lebar" amajeyan ‏pêdrawe, we ‏‎(MiRKir)‎‏ bo ew kurmancaney ke be ‏‏"kurmancî xrap" lelayen kurmancye ‏axêwerekanî şanşînî berîtana amajeyan pê dedrêt (‏‎(Yilmaz, 2018‎‏.)‏‎ (MIGT)‎‏ legell ‏pirsyarekanî peywest be pey birdin be zansitî zarawekan, bo nmûne sernicî ‏wellamgokanî naw ‏em twêjîneweye bo nawçe, ayîn, regez û çîn, ewe pîşandeden ke hewlliwêstekan ‏derbarey ‏ewaney ke be ‏‎(BiHKir)‎‏ û be ‏‎(MiRKir)‎‏ debînrên zor cyawazn. Be terkîz kirdne ser ‏hellwêste zmanîyekan ‏derbarey kurmancî ke hergîz pêştir le şanşîne yekgirtuwekan dîrase ‏nekrawe , em babete ‏lêkollînewe le hellsengandne erênî û nerênîyekanî heryek le ‏‎(BiHKir)‎‏ û ‏‎(MiRKir)‎‏ le peywend be ‏întîmay dînî dekat. Abstract in Zazaki Tewrê ziwanî û dîn: kurdê elewî yê Qiralîya Yewbîyayîye Ez na meqale de netîceyanê cigêrayîşê Testanê Seypêkerdeyan ê Guiseyî (MGT) ke derheqê tewranê ziwanî yê kurmancîya Botanî (BHKr) û Mereşî (MRKr) yê ke dîyasporaya Qiralîya Yewbîyayîye de qesey benê, înan analîz kena. Ez giranî dana BHKr ser ke hetê qiseykerdoxanê kurmancî yê Qiralîya Yewbîyaye sey “kurmancîya rinde” yan zî “kurmancîya akademîke/raşte” hesibnîyena, û MRK ser ke sey “kurmancîya xirabine” hesibnîyena (Yilmaz, 2018). MGT û persê ke derheqê dîyalektolojîya îdrakîye de yê, sey dîyayîşê îdrakkerdoxan yê herêm, dîn, cinsîyet û sinife ke na meqale de ca girewto, ê musnenê ke tewrê înan ê hemverê BHKr û MRK yewbînan ra zaf cîya yê. Pê giranîdayîşê tewranê zimanî yê hemverê kurmancî ser, ke heta nika ê tewran ser o Qiralîya Yewbîyayîye de qet cigêrayîş nêameyo kerdene, na xebate erjnayîşanê BHRr û MRKr yê pozîtîf û negatîfan goreyê têkilîya xo ya dînî analîz kena.

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BORNSTEIN, MARC H. "Elizabeth Sears, The Ages of Man: Medieval Interpretations of the Life Cycle Patrick Mckee and Heta Kauppinen, The Art of Aging: A Celebration of Old Age in Western Art." Journal of Aesthetics and Art Criticism 47, no. 2 (March 1, 1989): 194–96. http://dx.doi.org/10.1111/1540_6245.jaac47.2.0194.

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Haig, Geoffrey, and Ergin Öpengin. "Introduction to Special Issue - Kurdish: A critical research overview." Kurdish Studies 2, no. 2 (October 10, 2014): 99–122. http://dx.doi.org/10.33182/ks.v2i2.397.

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Investigation of the regional variation in Kurmanji, especially its varieties spoken in Turkey, has been almost entirely neglected in the existing literature on Kurdish. In addition to earlier isolated examinations of Kurmanji dialects (cf. MacKenzie, 1961; Ritter, 1971, 1976; Blau, 1975; Jastrow, 1977), native-speaker researchers have recently provided a substantial amount of dialect material across the Kurmanji-speech zone. However, a methodologically-informed evaluation of these observations into a dialect classification is yet to be undertaken. This article aims at providing an initial classification of Kurmanji-internal variation into major regional dialects, based on lexical, phonological and morphosyntactic data collected from five localities in Southeastern Turkey. Cihêrengiya zimanî ya navxweyî di kurmanciyê de: tesnîfeke seretayî ya zaravayan Di nav xebatên li ser zimanê kurdî de, heta niha, vekolîna cudatiyên devok û zaravayên kurmanciyê, bi taybetî ewên di nav sînorên Tirkiyeyê de, hema bi temamî hatiye piştguhkirin. Ji bilî çend xebatên serbixwe yên pêştir li ser zaravayên kurmancî (wek MacKenzie 1961; Ritter, 1971 û 1976; Blau, 1976; Jastrow 1977), di nav van salên dawî de vekolerên kurdîziman qewareyeke mezin a dane û materyelên ji gelek zaravayên kurmanciyê berhev kirine. Lê belê, hêj ev çavdêriyên berbelav bi rengekî metodolojîk nehatine nirxandin ku tesnîfeke zaravayan jê bi dest bikeve. Ev meqale dil dike tesnîfeke seretayî ya zaravayên serekî yên kurmanciyê pêşkêş bike li ser bingehê daneyên peyvî û fonolojîk û rêzimanî yên li pênc deverên başûr-rojhilatê Tirkiyeyê berhevkirî. جیاوازی ناوچەیی لەناو کرمانجیدا: پۆلینبەندییەکی سەرەتایی زاراوەکانلەناو ئەو لێکۆڵینەوانەی کە سەبارەت بە جیاوازی ناوچەیی لە کرمانجیدا ئەنجام دراوە، بەتایبەت ئەوانەی کە لەمەڕ جۆربەجۆری ئەو [زاراوانەی] کە لە تورکیا قسەیان پێ دەکرێ، بەتەواوی لەمەڕ هەبوونی ئەدەبیاتێکی هەبوو بە زمانی کوردی چاوپۆشی دەکرێت. سەرەڕای چەند تاقیکردنەوەیەکی تاک و تەرا سەبارەت بە شێوەزارەکانی کرمانجی کە پێشتر بەئەنجام گەیشتوون (بەراوردی بکەن لەگەڵ مەک‌کینزی، ١٩٦١؛ ڕیتێر، ١٩٧١ و ١٩٧٦؛ بلەو، ١٩٧٦؛ یاسترۆ، ١٩٧٧) لەم ساڵانەی دواییدا توێژەرانی کورد ڕادەیەکی بەرچاو لە مادەی پێویست سەبارەت بە شێوەزارەکانی کرمانجییان لە دەڤەری کرمانجی ئاخێودا دەستەبەر کردووە. هەرچەند بەمەبەستی پۆلینبەندی زاراوەکان، هەتاکوو ئێستا، هەڵسەنگاندنێکی مێتۆدیک و پڕزانیاری لەسەر ئەم تێڕامانانە ئەنجام نەدراوە. ئامانجی ئەم وتارە بریتییە لەوەی کە پۆلینبەندییەکی سەرەتایی لەو جیاوازییە ناوخۆییەی کە لە زاراوە سەرەکییەکانی ناوچە کرمانجی ئاخێوەکاندا هەیە بەدەستەوە بدات و بۆ ئەم مەبەستە توێژینەوەکە لەسەر بنەمای ئەو داتا وشەیی، دەنگناسی و پێکهاتەی ڕێزمانییانە ئەنجام دەدرێت کە لە پێنج ناوچەی باشوری ڕۆژهەڵاتی تورکیا کۆ کراونەتەوە.

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Öpengin, Ergin, and Geoffrey Haig. "Regional variation in Kurmanji: A preliminary classification of dialects." Kurdish Studies 1, no. 1 (October 4, 2014): 143–76. http://dx.doi.org/10.33182/ks.v2i2.399.

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Historical linguistic sources of Kurdish date back just a few hundred years, thus it is not possiInvestigation of the regional variation in Kurmanji, especially its varieties spoken in Turkey, has been almost entirely neglected in the existing literature on Kurdish. In addition to earlier isolated examinations of Kurmanji dialects (cf. MacKenzie, 1961; Ritter, 1971, 1976; Blau, 1975; Jastrow, 1977), native-speaker researchers have recently provided a substantial amount of dialect material across the Kurmanji-speech zone. However, a methodologically-informed evaluation of these observations into a dialect classification is yet to be undertaken. This article aims at providing an initial classification of Kurmanji-internal variation into major regional dialects, based on lexical, phonological and morphosyntactic data collected from five localities in Southeastern Turkey.Cihêrengiya zimanî ya navxweyî di kurmanciyê de: tesnîfeke seretayî ya zaravayan Di nav xebatên li ser zimanê kurdî de, heta niha, vekolîna cudatiyên devok û zaravayên kurmanciyê, bi taybetî ewên di nav sînorên Tirkiyeyê de, hema bi temamî hatiye piştguhkirin. Ji bilî çend xebatên serbixwe yên pêştir li ser zaravayên kurmancî (wek MacKenzie 1961; Ritter, 1971 û 1976; Blau, 1976; Jastrow 1977), di nav van salên dawî de vekolerên kurdîziman qewareyeke mezin a dane û materyelên ji gelek zaravayên kurmanciyê berhev kirine. Lê belê, hêj ev çavdêriyên berbelav bi rengekî metodolojîk nehatine nirxandin ku tesnîfeke zaravayan jê bi dest bikeve. Ev meqale dil dike tesnîfeke seretayî ya zaravayên serekî yên kurmanciyê pêşkêş bike li ser bingehê daneyên peyvî û fonolojîk û rêzimanî yên li pênc deverên başûr-rojhilatê Tirkiyeyê berhevkirî.جیاوازی ناوچەیی لەناو کرمانجیدا: پۆلینبەندییەکی سەرەتایی زاراوەکان لەناو ئەو لێکۆڵینەوانەی کە سەبارەت بە جیاوازی ناوچەیی لە کرمانجیدا ئەنجام دراوە، بەتایبەت ئەوانەی کە لەمەڕ جۆربەجۆری ئەو [زاراوانەی] کە لە تورکیا قسەیان پێ دەکرێ، بەتەواوی لەمەڕ هەبوونی ئەدەبیاتێکی هەبوو بە زمانی کوردی چاوپۆشی دەکرێت. سەرەڕای چەند تاقیکردنەوەیەکی تاک و تەرا سەبارەت بە شێوەزارەکانی کرمانجی کە پێشتر بەئەنجام گەیشتوون (بەراوردی بکەن لەگەڵ مەک‌کینزی، ١٩٦١؛ ڕیتێر، ١٩٧١ و ١٩٧٦؛ بلەو، ١٩٧٦؛ یاسترۆ، ١٩٧٧) لەم ساڵانەی دواییدا توێژەرانی کورد ڕادەیەکی بەرچاو لە مادەی پێویست سەبارەت بە شێوەزارەکانی کرمانجییان لە دەڤەری کرمانجی ئاخێودا دەستەبەر کردووە. هەرچەند بەمەبەستی پۆلینبەندی زاراوەکان، هەتاکوو ئێستا، هەڵسەنگاندنێکی مێتۆدیک و پڕزانیاری لەسەر ئەم تێڕامانانە ئەنجام نەدراوە. ئامانجی ئەم وتارە بریتییە لەوەی کە پۆلینبەندییەکی سەرەتایی لەو جیاوازییە ناوخۆییەی کە لە زاراوە سەرەکییەکانی ناوچە کرمانجی ئاخێوەکاندا هەیە بەدەستەوە بدات و بۆ ئەم مەبەستە توێژینەوەکە لەسەر بنەمای ئەو داتا وشەیی، دەنگناسی و پێکهاتەی ڕێزمانییانە ئەنجام دەدرێت کە لە پێنج ناوچەی باشوری ڕۆژهەڵاتی تورکیا کۆ کراونەتەوە.

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Gunes, Cengiz. "Political Representation of Alevi Kurds in Turkey: Historical Trends and Main Transformations." Kurdish Studies 8, no. 1 (May 24, 2020): 71–90. http://dx.doi.org/10.33182/ks.v8i1.522.

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This article explains the process of change in the political representation of Alevi Kurds in Turkey since the country held its first competitive election in 1950. It applies process tracing methodology to identify the dominant trends in Alevi Kurds’ political representation and highlights how the mode of their political participation evolved over time. The discussion presented here develops an explanation that connects the effects of key events and processes that shapes the outcome of this complex political phenomenon. The strong appeal among Alevi Kurds of the Turkish socialist movement and the political parties that are associated with the secular republican regime is discussed before the impact of the rise of Alevi and Kurdish movements on the Alevi Kurds’ political representation is assessed. The barriers Turkey’s restrictive political and legal order place on Alevi Kurds’ political representation are also highlighted. ABSTRACT IN KURMANJI Temsîliyeta siyasî ya kurdên Elewî li Tirkiyeyê: Meylên dîrokî û veguherînên esasî Ev gotar proseya guherîna temsîliyeta siyasî ya kurdên Elewî li Tirkiyeyê, ya ji wexta hilbijartina ewil ya pêşbazîdar a 1950an heta îro, rave dike. Gotar, rêbaza şopandina prosesê tetbîq dike ku meylên serdest ên di temsîliyeta siyasî ya kurdên Elewî de rave bike û li ser disekine ka şêwaza beşdarî û temsîliyeta wan bi demê re çawa vediguhere. Nîqaşa ku li vir hatiye diyarkirin ravekirineke wusa dike ku tesîra bûyerên û proseyên girîng yên ku şikl didin encama vê fenomena sîyasî ya tevlîhev bi hev ve girê dide. Daxwaza xurt a di nav kurdên Elewî yên di nav tevgerên sosyalîst ên tirk û partiyên siyasî yên têkilî rejîma komarî ya sekuler de tê nîqaşkirin berî nirxandina tesîra bilindbûna tevgerên Elewî û kurd ên li ser temsîliyeta siyasî a kurdên Elewî de. Herwiha, bal hatiye kişandin ser astengiyên nîzama qanûnî û siyasî ya sînorker a Tirkiyeyê ya ku li ser temsîliyeta kurdên Elewî bi cih dike.

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OSAWA, Satoshi. "The Movement of Local Resourcing of Citrus tachibana which is Domestic Wild Citrus Fruits and Status of the Population of C. tachibana in Heta District, West Izu Peninsula." JOURNAL OF RURAL PLANNING ASSOCIATION 37, Special_Issue (November 20, 2018): 161–67. http://dx.doi.org/10.2750/arp.37.161.

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Ghaderi, Farangis. "The literary legacy of the Ardalans." Kurdish Studies 5, no. 1 (May 17, 2017): 32–55. http://dx.doi.org/10.33182/ks.v5i1.419.

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Classical Gorani literature is believed to be the oldest Kurdish literary tradition which under the patronage of the Ardalans developed into a “literary koinè” in the seventeenth and the eighteenth centuries. However, despite its antiquity and significance in the history of Kurdish literature, it has remained largely under-studied. It is against this backdrop that I offer an overview of Gorani literature, its history of development, and main literary characteristics in this article. Through extensive text analysis I examine the classical Gorani poetry for its major genres and forms and predominant themes and images. I study Gorani oral and written literature and their interactions, and the role it played in Kurdish poetic modernisation in the twentieth century.Abstract in KurmanjiMîrasa edebî ya ErdelaniyanEdebiyata goranî ya sunnetî wek kevntirîn kelepora edebî ya kurdî tê hesibandin, ku bi patronaja xanedana Erdelaniyan di sedsalên hevdeh û hejdehan de şiklê “koinèyeke edebî” wergirt. Lê belê, li gel qedîmî û girîngiya xwe bo dîroka edebiyata kurdî, heta niha kêm xebat li ser wê hatine kirin. Li ser vê paşxaneyê di vê gotarê de ez dixwazim giştiyekê li ser edebiyata goranî, li ser dîroka geşedana wê, û xasiyetên wê yên edebî yên serekî pêşkêş bikim. Bi rêya tehlîlên berfireh ên metnan ez dê cure û qalibên serekî û mezmûnên serdest ên edebiyata klasîk a goranî binirxînim. Herwiha behs dê bikeve ser edebiyata goranî ya devkî û ya nivîskî û têkiliya wan, li gel rola ku vê edebiyatê di nûjenkirina helbesta kurdî ya sedsala bîstan de gêraye.Abstract in SoraniKeleporî Edebîy ErdellanekanEdebiyatî klasîkî goranî be kontirîn edebî kurdî dadenrêt ke le sedekanî hevde w hejde be pallpiştî Erdellanekan wekû zimanî edebî hawbeş geşey kird. Bellam be pêçewaney kewnî w girîngîy le mêjûy edebî kurdî da, lêkollînewey zor kemî le ser kirawe. Lem wutare be leberçawgirtinî em paşxane, edebî goranî, mêjûy geşesendinî w layene edebîye berçawekanî bas dekem. Le rêgey şîkarî deqî şî‘rî klasîkî goranî, janr û form û herweha têma w wêna serekîyekan şirove dekem. Em wutare herweha edebî zarekî w nûsrawey koranî w pêwendîyan û rollî le nûkirdinewey şî‘rî kurdî le sedey bîstem tawtwê dekat.

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Pratt, G., R. Hough, and M. Rechsteiner. "Proteolysis in Heat-stressed HeLa Cells." Journal of Biological Chemistry 264, no. 21 (July 1989): 12526–32. http://dx.doi.org/10.1016/s0021-9258(18)63889-x.

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Pohl, Jonathan Otto. "Kurds in the USSR, 1917-1956." Kurdish Studies 5, no. 2 (October 26, 2017): 157–71. http://dx.doi.org/10.33182/ks.v5i2.442.

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Soviet policy towards its Kurds fluctuated and remained fragmented, ambivalent, and inconsistent throughout the existence of the USSR. On one hand, the Soviet government provided for the material and cultural development of Kurds in Armenia and Azerbaijan during the 1920s and 1930s. On the other hand, in 1937 it deported a number of Kurds from Azerbaijan and in 1944 an even larger number from Georgia to Kazakhstan and Central Asia as special settlers. The Soviet government only freed Kurdish special settlers from the legal restrictions limiting their movement and other rights in April 1956. Former Kurdish special settlers, however, could not return to the Caucasus. The Kurds remained a diaspora group in the USSR without any national territory and only limited cultural institutions. Only in the late 1980s did this situation change.ABSTRACT IN KURMANJIKurd li Yekîtiya Komarên Sosyalîst ên Sovyetan ji 1917 heta 1956Siyaseta Sovyetan beramber kurdên xwe, di hemû tarîxa YKSS de, pir caran guherî û hergav pirserî, xumam û nelihev bû. Li milekî, salên 1920an û 1930yan, dewleta Sovyetê îmkan dabîn kirin ji bo pêşketina çandî û samanî ya kurdên Ermenistan û Azerbeycanê. Li milê din, heman dewletê sala 1937an hejmareke kurdên Azerbeycanê û sala 1944an jî hejmareke pir mezintir a kurdên Gurcistanê wek muhacirên taybet şandine Qazaxistan û Asyaya Navendî. Dewleta Sovyetê şertên taybet ên li ser kurdên muhacir, yên ku bo nimûne nedihêlan ew ji cihekî biçin cihên din, bes di nîsana 1956an de rakirin. Lê belê, muhacirên kurd ên destê pêşiyê nekarîn bizivirine Qefqazyayê. Kurd li YKSS wek cemaeteke diasporayê veman bêyî ti erdekî xwe yê neteweyî û bi tenê bi hindek dezgehên çandî. Bi tenê salên dawî yên 1980an ev rewş guherî. ABSTRACT IN SORANIKurd le Yekyetî Sovîyet 1917 ta 1956Siyasetî Yekîyetî Sovyet le beramber Kurdekanî xoyda berz û nizmî be xoyewe bînîwe û le hemû temenî Yekîyetî Sovîyetda be şêweyekî natewaw, rarrayî û neguncaw mayewe. Le layenêkewe, ḧikumetî Yekîyetî Sovîyet, le nêwan sallekanî 1920 û 1930ekan, helumercî bo geşey binerretî û kultûrîy Kurdekan le Ermeniya û Azerbaycan rexisand. Le layenêkî tirewe, le sallî 1937 jimareyek le Kurdekanî le Azerbaycan derkird û tenanet le sallî 1944 jimareyekî zor ziyatir lewanî, wekû koçerî taybet, le Corciyawe rewaney Qezaxistan û Asyay Nawendî kird. Tenya le aprîlî 1956da, ḧikumetî Yekîyetî Sovîyet berbende yasayîyekanî le ser azadî hatûçû û mafekanî tirî em koçere taybetane hellweşandewe. Bellam, ew kurdaney ke pêştir kirabûn be koçer yan nêştecêy taybet boyan nebû bigerrênewe bo nawçey Qefqaz. Kurdekan wekû grupêkî diyaspora le Yekîyetî Sovîyetda manewe, bê ewey herêmêkî nîştimanîyan hebê û tenya çend enistîtoyekî kultûrîy sinûrdaryan pê dra. Tenya le kotayî heştakanî sedey bîstemda doxeke gorrankarî beserda hat.

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DEMIRANDA, S., and M. MELLO. "Interference images of heat-shocked HeLa cells." Cell Biology International Reports 14 (September 1990): 180. http://dx.doi.org/10.1016/0309-1651(90)90822-g.

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Hattori, H., T. Kaneda, B. Lokeshwar, A. Laszlo, and K. Ohtsuka. "A stress-inducible 40 kDa protein (hsp40): purification by modified two-dimensional gel electrophoresis and co-localization with hsc70(p73) in heat-shocked HeLa cells." Journal of Cell Science 104, no. 3 (March 1, 1993): 629–38. http://dx.doi.org/10.1242/jcs.104.3.629.

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We have previously reported that a novel 40 kDa protein is induced by heat shock and several environmental stresses in mammalian and avian cells and that the N-terminal amino acid sequence of this 40 kDa protein has homology with the bacterial DnaJ heat-shock protein. We have purified this protein (40 kDa heat-shock protein, hsp40) from HeLa cells by modified two-dimensional gel electrophoresis and generated a polyclonal antibody against hsp40. This antibody was highly specific for human hsp40 and cross-reacted weakly with rat and Chinese hamster hsp40. Indirect immunofluorescence revealed that the hsp40 in HeLa cells accumulates in the nucleus, especially in the nucleolus, during heat shock and returns to the cytoplasm during the recovery period. The kinetics of the accumulation in the nucleoli and subsequent return to the cytoplasm of hsp40 was similar to that of hsp70. In addition, hsp40 was co-localized with hsc70(p73) in heat-shocked HeLa cells as demonstrated by double immunofluorescence staining. These results suggest that hsp40 (a DnaJ homologue) and hsp70 (a DnaK homologue) may act in concert to repair (refold) denatured proteins and protein aggregates in the nuclei and nucleoli of heat-shocked HeLa cells.

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Rajan, Teena, Benluvankar V, and Vincent S. "SACCHAROMYCES CEREVISIAE-INDUCED APOPTOSIS OF MONOLAYER CERVICAL CANCER CELLS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 8 (August 1, 2017): 63. http://dx.doi.org/10.22159/ajpcr.2017.v10i8.18818.

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Objective: The present study was undertaken to examine the effect of phagocytosis of killed yeast on the induction of apoptosis in monolayer of HeLa cells.Methods: HeLa cell line was incubated with different doses (1000-7.8 μg/ml) of heat-killed Saccharomyces cerevisiae for 24, 48, and 72 hrs. The cytotoxicity against HeLa cell line during different exposure hours was screened by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-tetrazolium bromide assay. Induction of apoptosis was further confirmed by morphological and biochemical examination. Antiproliferative effect of yeast was examined under inverted microscope. Cell morphological changes were analyzed by fluorescent staining with propidium iodide.Results: The results showed that yeast induces cytotoxicity against HeLa cells in concentrations and during prolonged exposure periods. The viability of HeLa cells decreased from 85% to 45% during 72 hrs of treatment with 1000 μg/ml of yeast cells. The inhibitory concentration 50% of heat-killed yeast required to induce 50% inhibition of HeLa cells was 62.5 μg/ml. Apoptotic cells showed signs such as cell enlargement, membrane blebbing, and chromatin condensation. Furthermore, cell cycle analysis showed that S. cerevisiae treated HeLa cells and showed a typical apoptosis pattern of DNA content that reflected sub-G0 phase (corresponding to apoptotic cells).Conclusion: Results from the present work show that the heat-killed yeast has anticancer activity and it includes apoptosis of HeLa cells in vitro.

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Mello, Maria Luiza S., and Sílvia R. P. Miranda. "Interference image analysis of heat-shocked HeLa cells." Acta Histochemica 93, no. 1 (January 1992): 249–55. http://dx.doi.org/10.1016/s0065-1281(11)80217-5.

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Bajalan, Djene Rhys. "Kurdish Responses to Imperial Decline: The Kurdish Movement and the End of Ottoman Rule in the Balkans (1878 to 1913)." Kurdish Studies 7, no. 1 (June 2, 2019): 51–71. http://dx.doi.org/10.33182/ks.v7i1.481.

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Focusing on the period between 1878 and 1913, this paper seeks to add to the growing literature highlighting the complexities of identity in the late Ottoman period through an examination of the attitudes of Kurdish political activists towards the specific question of the dissolution of Ottoman rule on the Balkan Peninsula. More precisely, it will be argued that, although it is impossible to identify a single Kurdish response to Ottoman troubles in the Balkans, a survey of contemporaneous publications indicates that many leading Kurdish public figures of the period, including those active within the nascent Kurdish movement, regarded Ottoman imperial collapse as a profoundly negative political development.ABSTRACT IN KURMANJIBersivên kurdan bo paşketina împeretoriyê: Tevgera kurdî û dawiya desthilata Osmanî li Balkanan (1878-1913)Ev gotar berê xwe dide nivîsînên her zêdetir ên li ser tevliheviya nasnameyê di serdema dawî ya Osmaniyan de bi rêya tehlîlkirina helwêstên çalakvanên siyasî yên kurd li hember pirsa hilweşîna desthilata Osmanî li Balkanan, bi taybetî di qonaxa ji 1878 heta 1913an. Bi gotineke deqîqtir, gotar wê hizrê dide pêş ku herçend xeyrî mumkîn e ku yek bersiveke kurdan ya bi tenê bê destnîşankirin ji bo kêşeyên Osmaniyan li herêma Balkanan, nirxandineke weşanên hevçerx diyar dike ku gelek kesayetên naskirî yên kurd, ewên ku di tevgera nûzayî ya kurdî de çalak bûn jî di nav de, hilweşîna împeretoriya Osmanî wek geşedaneke gelek negatîv didîtin. ABSTRACT IN SORANIBersivî Kurd bo pukanewey împirator: Cullanewey Kurdî û kotayî ḧukimrranîy 'Usmanî le Balkan (1878-1913)Be terkîz kirdine ser mawey nêwan 1878 ta 1913, em babete hewll dedat îzafeyek bixate ser ew edebiyate rû le ziyadbuwey ke tîşk dexate ser allozîy şunas le kota qonaẍî 'Usmanîda le rêgey pişkinînî hellwêstî çalakwane siyasîye kurdîyekan le hember pirsêkî diyarîkiraw ke ewîş hellweşandinewey ḧukmî 'Usmanîyekan le durgey Ballkane. Wirdtir billêyn, argumêntî ewe dekirêt ke herçende destnîşankirdinî yek bersivî Kurdî derheq be kêşekanî 'Usmanîyekan le Balkan esteme, rûmallkirdinî billawkirawekanî ew serdeme amajey ewe dedat ke zorêk le kesayetîye giştîye diyarekanî kurdî ew kat, be waneşewe ke lenaw bizûtnewe kurdîye sawakeda çalak bûn, heresî împiratorîyetî 'Usmanîyan be allugorrêkî siyasîy nerênîy qull dadena.ABSTRACT IN ZAZAKIRijîyayîşê Împeratorîye rê cewabê kurdan: Balkanan de peynîya hukmê Osmanîyan de tevgerê kurdan (1878 – 1913)Bi giranîya serranê mabênê 1878 û 1913î, na meqale kena ke dewrê Osmanîyan ê peyênî de edebîyato ke derheqê kompleksîteyanê nasnameyan ê Balkanan de aver şono, ey ser o kemerêke rono. Tede derheqê persê wedarîyayîşêhukmê Osmanîyan ê nêmgirawa Balkanî de qenaetê çalakîkeranê sîyasetmedaranê kurdan ê wextî analîz benê. Hîna biteferuat, îdîa beno ke herçiqas ke mumkîn nîyo ke derheqê problemanê Osmanîyan ê Balkanî de tena yew cewabê kurdan bêro teşxîskerdene, ancîya cigêrayîşê weşanê ê demî musneno ke xeylê şexsîyetanê kurdan ê namdaran yê ê wextî, çalakîkerê tevgerê neteweperwerîya kurdan ya tezîye zî tede, parçebîyayîşê Împeratorîya Osmanîyan sey averşîyayîşêko sîyasîyo xirabin dîyêne.

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Schiemann, D. A., and C. M. Nelson. "Antibody inhibition of HeLa cell invasion by Yersinia enterocolitica." Canadian Journal of Microbiology 34, no. 1 (January 1, 1988): 52–57. http://dx.doi.org/10.1139/m88-009.

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Antisera were prepared in rabbits against formalized and heat-killed bacteria of Yersinia enterocolitica serotype O:5,27 and against formalized bacteria of serotype O:8. Both strains used for immunization demonstrated adhesion to and invasion of HeLa cells. Coating of the bacteria with antibody did not greatly alter adhesion (i.e., extracellular attachment) to HeLa cells; however, antibody against formalized bacteria of both serotypes inhibited HeLa cell invasion by the homologous and heterologous strains. The Fab fragments from purified immunoglobulins also demonstrated cross-reacting inhibition of HeLa cell invasion. Antibody against heat-killed bacteria of serotype O:5,27 had no inhibitory activity. Adsorption of the antiserum against formalized bacteria of serotype O:5,27 with lipopolysaccharide from the homologous strain removed anti-lipopolysaccharide antibody but did not remove the inhibitory activity. The antiserum against formalized bacteria of serotype O:8 showed no antibody against lipopolysaccharide from serotype O:5,27 and no agglutinins against heat-killed bacteria of this strain. From these results, it is tentatively suggested that protein structures are important in mediating epithelial cell invasion by Y. enterocolitica.

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Andrews, G. K., M. A. Harding, J. P. Calvet, and E. D. Adamson. "The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene." Molecular and Cellular Biology 7, no. 10 (October 1987): 3452–58. http://dx.doi.org/10.1128/mcb.7.10.3452.

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Several known inducers of the heat shock response (heat stress, arsenite, and heavy metals) were shown to cause a significant elevation of c-fos mRNA in HeLa cells. Heat stress resulted in a time- and temperature-dependent prolonged elevation in the level of c-fos mRNA, which was accompanied by increased translation of c-fos protein and its appearance in the nucleus. Elevated expression of c-fos during heat stress was paralleled by induction of hsp 70 mRNA, while levels of c-myc and metallothionein mRNAs declined. Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA. Although elevated expression of c-fos was prevented by inhibitors of RNA synthesis, analysis of relative rates of gene transcription showed that during heat stress there was a negligible change in c-fos transcription. Therefore, the enhanced expression of c-fos during the heat shock response is likely to occur primarily through posttranscriptional processes. Cycloheximide was also shown to significantly increase the c-fos mRNA level in HeLa cells. There results are consistent with the observation that these inducers of the heat shock response, as well as cycloheximide, repress protein synthesis and suggest that the increase in the level of c-fos mRNA is caused by an inhibition of protein synthesis. This supports the hypothesis that c-fos mRNA is preferentially stabilized under conditions which induce the heat shock response, perhaps by decreased synthesis of a short-lived protein which regulates c-fos mRNA turnover.

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Andrews, G. K., M. A. Harding, J. P. Calvet, and E. D. Adamson. "The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene." Molecular and Cellular Biology 7, no. 10 (October 1987): 3452–58. http://dx.doi.org/10.1128/mcb.7.10.3452-3458.1987.

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Several known inducers of the heat shock response (heat stress, arsenite, and heavy metals) were shown to cause a significant elevation of c-fos mRNA in HeLa cells. Heat stress resulted in a time- and temperature-dependent prolonged elevation in the level of c-fos mRNA, which was accompanied by increased translation of c-fos protein and its appearance in the nucleus. Elevated expression of c-fos during heat stress was paralleled by induction of hsp 70 mRNA, while levels of c-myc and metallothionein mRNAs declined. Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA. Although elevated expression of c-fos was prevented by inhibitors of RNA synthesis, analysis of relative rates of gene transcription showed that during heat stress there was a negligible change in c-fos transcription. Therefore, the enhanced expression of c-fos during the heat shock response is likely to occur primarily through posttranscriptional processes. Cycloheximide was also shown to significantly increase the c-fos mRNA level in HeLa cells. There results are consistent with the observation that these inducers of the heat shock response, as well as cycloheximide, repress protein synthesis and suggest that the increase in the level of c-fos mRNA is caused by an inhibition of protein synthesis. This supports the hypothesis that c-fos mRNA is preferentially stabilized under conditions which induce the heat shock response, perhaps by decreased synthesis of a short-lived protein which regulates c-fos mRNA turnover.

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Legagneux, Vincent, Marie-Françoise Dubois, Michel Morange, and Olivier Bensaude. "Phosphorylation of the 90 kDa heat shock protein in heat shocked HeLa cell lysates." FEBS Letters 231, no. 2 (April 25, 1988): 417–20. http://dx.doi.org/10.1016/0014-5793(88)80862-7.

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Huang, L. E., L. Caruccio, A. Y. Liu, and K. Y. Chen. "Rapid activation of the heat shock transcription factor, HSF1, by hypo-osmotic stress in mammalian cells." Biochemical Journal 307, no. 2 (April 15, 1995): 347–52. http://dx.doi.org/10.1042/bj3070347.

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Osmoregulation is important to living organisms for survival in responding to environmental changes of water and ionic strength. We demonstrated here for the first time that exposure of HeLa cells to a hypotonic medium (30% growth medium and 70% water) prominently induced the binding activity of the heat shock transcription factor (HSF). Pretreatment of cells with cycloheximide did not inhibit the induction of HSF-binding activity, indicating that the mechanisms of induction are independent of new protein synthesis. The magnitude of hypo-osmotic stress-induced HSF-binding activity was comparable with that induced by heat shock. The induction, as monitored by gel-mobility-shift assay, occurred within 5 min of hypo-osmotic stress and persisted at least up to 4 h in HeLa cells under the hypotonic conditions. Addition of sorbitol to the hypotonic medium abolished HSF activation. Hypo-osmotic stress-induced HSF binding could also be demonstrated in HeLa cells maintained in simple sorbitol solution by decreasing the sorbitol concentration from 300 mM to 200 mM or less. Competition analysis suggests that the effects of hypo-osmotic stress on HSF-binding activity was specific. Cross-linking experiments and Western-blot analysis demonstrated that hypo-osmotic stress induced trimerization of human heat shock factor 1 (HSF1) in intact HeLa cells, suggesting that trimer formation of HSF1 was responsible for inducing HSF-binding activity in hypo-osmotically stressed cells. However, unlike heat shock response, the activation of HSF by hypo-osmotic stress did not lead to accumulation of hsp70 mRNA in HeLa cells.

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Warters, Raymond L., and Louis R. Barrow. "Heat sensitivity of Hela S3 Cell DNA topoisomerase II." Journal of Cellular Physiology 159, no. 3 (June 1994): 468–74. http://dx.doi.org/10.1002/jcp.1041590311.

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Zheng, Yang Yan, Yi Ning Wang, Qun Hui Lu, and Biao Yuan. "Simulation Study of Strengthening Heat Transfer of Heat Exchanger with Notched Turbolator." Applied Mechanics and Materials 448-453 (October 2013): 1278–83. http://dx.doi.org/10.4028/www.scientific.net/amm.448-453.1278.

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This paper establishes a model of turbolator with arc notches at its edges to simulation the heat transfer and flowing characteristics of hetat exchanger. Results show that notched turbolator apparently enhanced the heat transfer and changes form of flowing inside tube apparently.

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Legagneux, Vincent, Michel Morange, and Olivier Bensaude. "Heat shock increases turnover of 90 kDa heat shock protein phosphate groups in HeLa cells." FEBS Letters 291, no. 2 (October 21, 1991): 359–62. http://dx.doi.org/10.1016/0014-5793(91)81320-8.

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Morgan, W. D., G. T. Williams, R. I. Morimoto, J. Greene, R. E. Kingston, and R. Tjian. "Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter." Molecular and Cellular Biology 7, no. 3 (March 1987): 1129–38. http://dx.doi.org/10.1128/mcb.7.3.1129.

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We characterized the activity of a human hsp70 gene promoter by in vitro transcription. Analysis of 5' deletion and substitution mutants in HeLa nuclear extracts showed that the basal activity of the promoter depends primarily on a CCAAT-box sequence located at -65. A protein factor, CCAAT-box-binding transcription factor (CTF), was isolated from HeLa nuclear extracts and shown to be responsible for stimulation of transcription in a reconstituted in vitro system. DNase I footprinting revealed that CTF interacts with two CCAAT-box elements located at -65 and -147 of the human hsp70 promoter. An additional binding activity, heat shock transcription factor (HSTF), which interacted with the heat shock element, was also identified in HeLa extract fractions. This demonstrates that the promoter of this human hsp70 gene interacts with at least two positive transcriptional activators, CTF, which is required for CCAAT-box-dependent transcription as in other promoters such as those of globin and herpes simplex virus thymidine kinase genes, and HSTF, which is involved in heat inducibility.

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