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Journal articles on the topic 'Heterobifunctional Polymers'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Liu, Chengbin, Yulin Wu, Xiaojian Wang, Zhang Hu, and Shenglian Luo. "Multifunctional PEG-grafted chitosan copolymer possessing amino and carboxyl (or formyl) groups." Open Chemistry 8, no. 3 (2010): 576–81. http://dx.doi.org/10.2478/s11532-010-0013-3.

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AbstractNew multifunctional PEG-grafted chitosan copolymers possessing both amino and carboxyl (4) or formyl (5) groups were synthesized by the grafting reaction method between chitosan and heterobifunctional PEG from anionic polymerization of ethylene oxide. Completion of the reactions and characterization of the resulting polymers were demonstrated by 1H NMR, FT-IR and GPC studies. The multifunctional polymers may have potential utility in gene/drug co-delivery or heterogeneous catalysis.

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2

Kim, Yong Joo, Yukio Nagasaki, Kazunori Kataoka, et al. "Heterobifunctional poly(ethylene oxide)." Polymer Bulletin 33, no. 1 (1994): 1–6. http://dx.doi.org/10.1007/bf00313466.

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3

Agarwal, Deepali, Kushal Sen, and M. L. Gulrajani. "Application of heterobifunctional reactive dyes on silk." Journal of the Society of Dyers and Colourists 112, no. 1 (2008): 10–16. http://dx.doi.org/10.1111/j.1478-4408.1996.tb01748.x.

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4

Wang, Max Mu, Mihai Ioan Truica, Sarki Abdulkadir, and Nathan Gianneschi. "HYbrid DegRAding Copolymer (HYDRAC): Heterobifunctional polymers for targeted degradation of undruggable proteins." JCO Global Oncology 9, Supplement_1 (2023): 22. http://dx.doi.org/10.1200/go.2023.9.supplement_1.22.

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22 Background: Of the ~20,000 proteins encoded by the human genome, only a small subset can be modulated via traditional pharmacological approaches. Included in the list of “undruggable” proteins are ones with pivotal roles in cancer. We aim to expand the arsenal of compounds able to affect the activity of these therapeutically relevant targets by introducing a modular proteomimetic platform technology designed to carry side chains consisting of targeting warheads and recruiters of cellular protein degradation machinery. We term these compounds HYbrid DegRAding Copolymers (HYDRACs) in referenc

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5

Vadala, M. L., M. S. Thompson, M. A. Ashworth, et al. "Heterobifunctional Poly(ethylene oxide) Oligomers Containing Carboxylic Acids." Biomacromolecules 9, no. 3 (2008): 1035–43. http://dx.doi.org/10.1021/bm701067d.

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6

Vojkovsky, Tomas, Bradford Sullivan, and Kevin N. Sill. "Synthesis of heterobifunctional polyethylene glycols: Polymerization from functional initiators." Polymer 105 (November 2016): 72–78. http://dx.doi.org/10.1016/j.polymer.2016.10.015.

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7

Thompson, M. S., T. P. Vadala, M. L. Vadala, Y. Lin, and J. S. Riffle. "Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers." Polymer 49, no. 2 (2008): 345–73. http://dx.doi.org/10.1016/j.polymer.2007.10.029.

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8

Ehteshami, Gholam, Jerker Porath, and Roberto Guzmán. "Interactions and applications of soluble heterobifunctional affinity chelating polymers in immobilized metal affinity chromatography." Journal of Molecular Recognition 9, no. 5-6 (1996): 733–37. http://dx.doi.org/10.1002/(sici)1099-1352(199634/12)9:5/6<733::aid-jmr331>3.0.co;2-f.

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9

Székely, György, Marc Schaepertoens, Piers R. J. Gaffney, and Andrew G. Livingston. "Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG." Polym. Chem. 5, no. 3 (2014): 694–97. http://dx.doi.org/10.1039/c3py01367g.

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10

Li, Zhongyu, and Ying Chau. "Synthesis of heterobifunctional poly(ethylene glycol)s by an acetal protection method." Polymer Chemistry 1, no. 10 (2010): 1599. http://dx.doi.org/10.1039/c0py00310g.

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11

Li, Zhongyu, and Ying Chau. "A facile synthesis of branched poly(ethylene glycol) and its heterobifunctional derivatives." Polymer Chemistry 2, no. 4 (2011): 873. http://dx.doi.org/10.1039/c0py00339e.

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12

Pohlit, Hannah, Matthias Worm, Jens Langhanki, Elena Berger-Nicoletti, Till Opatz, and Holger Frey. "Silver Oxide Mediated Monotosylation of Poly(ethylene glycol) (PEG): Heterobifunctional PEG via Polymer Desymmetrization." Macromolecules 50, no. 23 (2017): 9196–206. http://dx.doi.org/10.1021/acs.macromol.7b01787.

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13

Kurusu, Fumiyo, Hiroyuki Ohno, Mitsuhiro Kaneko, Yukio Nagasaki, and Kazunori Kataoka. "Functionalization of gold electrode surface with heterobifunctional poly(ethylene oxide)s having both mercapto and aldehyde groups." Polymers for Advanced Technologies 14, no. 1 (2003): 27–34. http://dx.doi.org/10.1002/pat.286.

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14

Du, Yong-Zhong, and Masato Kodaka. "Preparation and characterization of biotinylated and enzyme-immobilized heterobifunctional latex particles as nanobio devices." Journal of Polymer Science Part A: Polymer Chemistry 43, no. 3 (2004): 562–74. http://dx.doi.org/10.1002/pola.20556.

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15

Wang, Yun, Lu Lu, Hu Wang, Dairen Lu, Kang Tao та Ruke Bai. "A Facile Strategy for Preparation of α-Heterobifunctional Polystyrenes with Well-Defined Molecular Weight". Macromolecular Rapid Communications 30, № 22 (2009): 1922–27. http://dx.doi.org/10.1002/marc.200900454.

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16

Kang, Suk Hoon, Ki Suk Jang, Patrick Theato, Rudolf Zentel, and Ji Young Chang. "Photoimaging through in-Situ Photopolymerization of Heterobifunctional Mesogenic Compounds in Liquid Crystalline State." Macromolecules 40, no. 23 (2007): 8349–54. http://dx.doi.org/10.1021/ma0712293.

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17

You, Ye-Zi, and David Oupický. "Synthesis of Temperature-Responsive Heterobifunctional Block Copolymers of Poly(ethylene glycol) and Poly(N-isopropylacrylamide)." Biomacromolecules 8, no. 1 (2007): 98–105. http://dx.doi.org/10.1021/bm060635b.

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18

Zeng, Faquan, and Christine Allen. "Synthesis of Carboxy-Functionalized Heterobifunctional Poly(ethylene glycol) by a Thiol-Anionic Polymerization Method." Macromolecules 39, no. 19 (2006): 6391–98. http://dx.doi.org/10.1021/ma0607665.

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19

Xiao, Hang, Chunhong Li, Peng Wang, and Tao Zhao. "A feasible approach for enhancing union dyeing of wool/acrylic blend fabrics with heterobifunctional cationic reactive dyes." Textile Research Journal 89, no. 23-24 (2019): 5085–95. http://dx.doi.org/10.1177/0040517519849452.

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In this work, a facile method to enhance union dyeing with cationic reactive dyes on wool/acrylic blend fabrics was reported. Three cationic reactive dyes containing various numbers of reactive groups were synthesized and employed on wool, acrylic and wool/acrylic blend fabrics using the one-bath one-step method. Factors affecting the dye exhaustion, union dyeing and leveling properties, including dyeing pH, temperature and dye structure, were investigated. Experimental results revealed that the cationic reactive dye containing heterobifunctional reactive groups and a cationic group attached o

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20

Otsuka, Hidenori, Yukio Nagasaki, Yasuhiro Horiike, Teruo Okano, and Kazunori Kataoka. "Novel Micropaterned Surface Fabricated from Heterobifunctional Poly(ethylene glycol)/polylactide Block Copolymers for Patterned Cell Culture." Journal of Photopolymer Science and Technology 14, no. 1 (2001): 101–4. http://dx.doi.org/10.2494/photopolymer.14.101.

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21

Blankenburg, Jan, та Holger Frey. "Convenient Access to α‐Amino‐ω‐Hydroxyl Heterobifunctional PEG and PPO via a Sacrificial Hexahydro‐Triazine Star Strategy". Macromolecular Rapid Communications 40, № 9 (2019): 1900020. http://dx.doi.org/10.1002/marc.201900020.

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22

Taguchi, Ryoichi, Masaki Nakahata, Yuri Kamon, and Akihito Hashidzume. "Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide–Alkyne Cycloaddition." Polymers 15, no. 9 (2023): 2199. http://dx.doi.org/10.3390/polym15092199.

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Ruthenium(II)-catalyzed azide–alkyne cycloaddition (RuAAC) polymerization of t-butyl 4-azido-5-hexynoate (tBuAH), i.e., a heterobifunctional monomer carrying azide and alkyne moieties, was investigated in this study. RuAAC of the monofunctional precursors of tBuAH yielded a dimer possessing a 1,5-disubstituted 1,2,3-triazole moiety. 1H NMR data showed that the dimer was a mixture of diastereomers. Polymerization of tBuAH using ruthenium(II) (Ru(II)) catalysts produced oligomers of Mw ≈ (2.7–3.6) × 103 consisting of 1,5-disubstituted 1,2,3-triazole units (1,5-units) as well as 1,4-disubstituted

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23

Nabid, Mohammad Reza, Mahvash Abedi, and Seyed Jamal Tabatabaei Rezaei. "Synthesis of A2B2 miktoarm star copolymers from a new heterobifunctional initiator by combination of ROP and ATRP." Polymer Bulletin 68, no. 5 (2011): 1327–39. http://dx.doi.org/10.1007/s00289-011-0620-y.

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24

Ishii, Takehiko, Masayoshi Yamada, Takumi Hirase, and Yukio Nagasaki. "New Synthesis of Heterobifunctional Poly(ethylene glycol) Possessing a Pyridyl Disulfide at One End and a Carboxylic Acid at the Other End." Polymer Journal 37, no. 3 (2005): 221–28. http://dx.doi.org/10.1295/polymj.37.221.

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25

Bianco, C. C., C. Menti, G. A. Lorensi, et al. "Thiol Ligand Adsorption on Gold Nanoparticle Surfaces: Mathematical Models to Predict Optimal Concentration of Heterobifunctional Polyethylene Glycol for Horseradish Peroxidase Immobilization." Advanced Science, Engineering and Medicine 12, no. 4 (2020): 473–83. http://dx.doi.org/10.1166/asem.2020.2547.

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Gold nanoparticles (GNPs) are often used in numerous applications, including diagnostics, drug delivery and treatment of diseases, given its physical features and excellent biocompatibility, where factors such as dispersion and stability are directly related to the its performance and efficiency. Mathematical models for experimental design can be very useful and contribute to predict optimal functionalization strategies. Therefore, the purpose of this work was to stabilize and functionalize GNPs of 40 nm and 80 nm and determine optimal concentrations of heterobifunctional polyethylene glycols

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26

Pagels, Robert F., Nathalie M. Pinkerton, Adam W. York, and Robert K. Prud'homme. "Synthesis of Heterobifunctional Thiol‐poly(lactic acid)‐ b ‐poly(ethylene glycol)‐hydroxyl for Nanoparticle Drug Delivery Applications." Macromolecular Chemistry and Physics 221, no. 2 (2019): 1900396. http://dx.doi.org/10.1002/macp.201900396.

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27

Ilkar Erdagi, Sevinc, Erdinc Doganci, Cavit Uyanik та Faruk Yilmaz. "Heterobifunctional poly(ε-caprolactone): Synthesis of α-cholesterol-ω-pyrene PCL via combination of ring-opening polymerization and “click” chemistry". Reactive and Functional Polymers 99 (лютий 2016): 49–58. http://dx.doi.org/10.1016/j.reactfunctpolym.2015.12.005.

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28

Duan, Donghai, Huijian Ye, Zhenggang Luo, et al. "Efficient Production of High‐Quality Polystyrene‐Functionalized Graphene via Graphite Exfoliation in Chloroform with a Heterobifunctional Hyperbranched Polyethylene as Stabilizer." Macromolecular Chemistry and Physics 220, no. 9 (2019): 1800577. http://dx.doi.org/10.1002/macp.201800577.

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29

Damodaran, Vinod B., та Conan J. Fee. "Synthesis and Evaluation of α-(β-Alanine)-ω-carboxy PEG Derivative as a Novel Cleavable Heterobifunctional PEG Tether for Solid-Phase Polymeric Drug Delivery". International Journal of Polymeric Materials 60, № 6 (2011): 398–408. http://dx.doi.org/10.1080/00914037.2010.531811.

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30

Wang, Jianli, Kejian Zhang, and Zhibin Ye. "One-Pot Synthesis of Hyperbranched Polyethylenes Tethered with Polymerizable Methacryloyl Groups via Selective Ethylene Copolymerization with Heterobifunctional Comonomers by Chain Walking Pd−Diimine Catalysis." Macromolecules 41, no. 6 (2008): 2290–93. http://dx.doi.org/10.1021/ma702049f.

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31

Zhang, Sheng, Jian Du, Rui Sun, et al. "Synthesis of heterobifunctional poly(ethylene glycol) with a primary amino group at one end and a carboxylate group at the other end." Reactive and Functional Polymers 56, no. 1 (2003): 17–25. http://dx.doi.org/10.1016/s1381-5148(03)00015-4.

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32

Goff, Jonathan, Santy Sulaiman, and Barry Arkles. "Applications of Hybrid Polymers Generated from Living Anionic Ring-Opening Polymerization." Molecules 26, no. 9 (2021): 2755. https://doi.org/10.3390/molecules26092755.

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Increasingly precise control of polymer architectures generated by “Living” Anionic Ring-Opening Polymerization (Living AROP) is leading to a broad range of commercial ad-vanced material applications, particularly in the area of siloxane macromers. While academic reports on such materials remain sparse, a significant portion of the global population interacts with them on a daily basis—in applications including medical devices, microelectronics, food packaging, synthetic leather, release coatings, and pigment dispersions. The primary driver of this increased utilization of si

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33

Maurizi, Lionel, Vanessa Bellat, Mathieu Moreau, et al. "Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine." RSC Advances 12, no. 41 (2022): 26875–81. http://dx.doi.org/10.1039/d2ra04753e.

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Titanate nanoribbons functionalized by heterobifunctional polymer and type I collagen for cellular adhesion and proliferation. This new nanobiohybrid affected neither cytotoxicity nor platelet aggregation ability.

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34

Bettinger, Thierry, Jean-Serge Remy, Patrick Erbacher, and Jean-Paul Behr. "Convenient Polymer-Supported Synthetic Route to Heterobifunctional Polyethylene Glycols." Bioconjugate Chemistry 9, no. 6 (1998): 842–46. http://dx.doi.org/10.1021/bc980039h.

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35

P., Kumar, C. Gupta K., and P. Gandhi R. "UV light-aided immobilization of oligonucleotides on glass surface using N -(3-trifluoroethanesulfonyloxypropyl)anthraquinone-2-carboxamide (NTPAC) and detection of single nucleotide mismatches." Journal of Indian Chemical Society Vol. 80, Dec 2003 (2003): 1193–99. https://doi.org/10.5281/zenodo.5839975.

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Nucleic Acids Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi Univer- sity Campus, Delhi-110 007, India E-mail : kcgupta@igib.res.in                         Fax : 91-11-27667471 Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110 007, India E-mail: gandhirp@yahoo.com                          Fax : 91-11-27666248 <em>Manuscript received 10 December 2003</em> A novel heterobifunctional reagent, <em>N</

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36

Senchyk, Ganna A., Harald Krautscheid та Kostiantyn V. Domasevitch. "Crystal structure of poly[[[μ4-3-(1,2,4-triazol-4-yl)adamantane-1-carboxylato-κ5 N 1:N 2:O 1:O 1,O 1′]silver(I)] dihydrate]". Acta Crystallographica Section E Crystallographic Communications 75, № 8 (2019): 1145–48. http://dx.doi.org/10.1107/s2056989019009708.

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The heterobifunctional organic ligand, 3-(1,2,4-triazol-4-yl)adamantane-1-carboxylate (tr-ad-COO− ), was employed for the synthesis of the title silver(I) coordination polymer, {[Ag(C13H16N3O2)]·2H2O} n , crystallizing in the rare orthorhombic C2221 space group. Alternation of the double μ2-1,2,4-triazole and μ2-η2:η1-COO− (chelating, bridging mode) bridges between AgI cations supports the formation of sinusoidal coordination chains. The AgI centers possess a distorted {N2O3} square-pyramidal arrangement with τ5 = 0.30. The angular organic linkers connect the chains into a tetragonal framework

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37

Sisson, Thomas M., Warunee Srisiri, and David F. O'Brien. "Novel Polymer Architectures via the Selective Polymerization of Lyotropic Liquid Crystals of Heterobifunctional Amphiphiles." Journal of the American Chemical Society 120, no. 10 (1998): 2322–29. http://dx.doi.org/10.1021/ja973371x.

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38

Wang, Max Mu. "Targeted degradation of undruggable proteins using a novel heterobifunctional proteomimetic platform." Journal of Clinical Oncology 42, no. 23_suppl (2024): 47. http://dx.doi.org/10.1200/jco.2024.42.23_suppl.47.

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47 Background: Of the ~20,000 proteins in the human genome, only a subset can be modulated via traditional pharmacological approaches. “Undruggable” targets currently include proteins with pivotal roles in cancer pathogenesis. Our work aims to introduce a new paradigm for engaging these clinically relevant proteins using a modular platform we term the HYbrid DegRAding Copolymers (HYDRACs). HYDRACs multiplex targeting warheads with degradation inducers and have long circulation times plus high cell uptake. Preliminary studies on MYC and RAS, targets of great pharmaceutical interest, highlight t

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39

Kang, Suk Hoon, Byung Mun Jung, Woo Jin Kim, and Ji Young Chang. "Embedding Nanofibers in a Polymer Matrix by Polymerization of Organogels Comprising Heterobifunctional Organogelators and Monomeric Solvents." Chemistry of Materials 20, no. 17 (2008): 5532–40. http://dx.doi.org/10.1021/cm800867b.

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40

Wang, M., M. Trucia, B. Gattis, S. Abdulkadir, and N. Gianneschi. "First-in-class heterobifunctional proteomimetic polymer capable of direct inhibition of Myc and target it for degradation." European Journal of Cancer 174 (October 2022): S36—S37. http://dx.doi.org/10.1016/s0959-8049(22)00897-8.

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41

Wang, Max, Mihai Truica, Brayley Gattis, Xiaoyu Zhang, Sarki Abdulkadir, and Nathan Gianneschi. "Abstract 3882: Targeted degradation of undruggable proteins using a novel heterobifunctional proteomimetic platform." Cancer Research 84, no. 6_Supplement (2024): 3882. http://dx.doi.org/10.1158/1538-7445.am2024-3882.

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Abstract Of the ~20,000 unique proteins in the human genome, only a subset can be modulated via traditional pharmacological approaches. “Undruggable” targets currently include proteins with pivotal roles in cancer pathogenesis. Our work aims to introduce a new paradigm for engaging these clinically relevant proteins using a modular platform we term the HYbrid DegRAding Copolymers (HYDRACs). HYDRACs multiplex targeting warheads with degradation inducers and have long circulation times plus high cell uptake. Preliminary studies on MYC and RAS, targets of immense pharmaceutical interest, highligh

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42

Yan, Mingdi, Sui Xiong Cai, M. N. Wybourne, and John F. W. Keana. "N-Hydroxysuccinimide Ester Functionalized Perfluorophenyl Azides as Novel Photoactive Heterobifunctional Crosslinking Reagents. The Covalent Immobilization of Biomolecules to Polymer Surfaces." Bioconjugate Chemistry 5, no. 2 (1994): 151–57. http://dx.doi.org/10.1021/bc00026a007.

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43

Kumar, P., S. K. Agarwal, and K. C. Gupta. "N-(3-Trifluoroethanesulfonyloxypropyl)anthraquinone- 2-carboxamide: A New Heterobifunctional Reagent for Immobilization of Biomolecules on a Variety of Polymer Surfaces." Bioconjugate Chemistry 15, no. 1 (2004): 7–11. http://dx.doi.org/10.1021/bc034198z.

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44

Loiseau, Alexis, Julien Boudon, Alexandra Oudot, et al. "Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors." Cancers 11, no. 12 (2019): 1962. http://dx.doi.org/10.3390/cancers11121962.

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Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid to their step-by-step synthesis. TiONts were synthesized by a hydrothermal process. To develop the custom-engineered nanohybrids, the surface of TiONts was coated beforehand with a siloxane (APTES), and coupled with both dithiolated diethylenetriaminepentaacetic acid-modified gold nanoparticles (Au@DTDTPA NPs) and a heterobifunctional polymer (PEG3000) to significantly improve suspension stability and biocompatibility of TiONts for targeted

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45

Raval, Yash S., Anna Samstag, Cedric Taylor, Guohui Huang, Olin Thompson Mefford, and Tzuen-Rong Jeremy Tzeng. "Assessing the Biocompatibility of Multi-Anchored Glycoconjugate Functionalized Iron Oxide Nanoparticles in a Normal Human Colon Cell Line CCD-18Co." Nanomaterials 11, no. 10 (2021): 2465. http://dx.doi.org/10.3390/nano11102465.

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We have previously demonstrated that iron oxide nanoparticles with dopamine-anchored heterobifunctional polyethylene oxide (PEO) polymer, namely PEO-IONPs, and bio-functionalized with sialic-acid specific glycoconjugate moiety (Neu5Ac(α2-3)Gal(β1-4)-Glcβ-sp), namely GM3-IONPs, can be effectively used as antibacterial agents against target Escherichia coli. In this study, we evaluated the biocompatibility of PEO-IONPs and GM3-IONPs in a normal human colon cell line CCD-18Co via measuring cell proliferation, membrane integrity, and intracellular adenosine triphosphate (ATP), glutathione GSH, dih

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46

Arkles, Barry, Jonathan Goff, Taewoo Min, et al. "Single Molecule Orthogonal Double-Click Chemistry- Inorganic to Organic Nanostructure Transition." ACS Applied Materials and Interfaces 12, no. 24 (2020): 27737–44. https://doi.org/10.1021/acsami.0c04018.

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Thiasilacyclopentane (TSCP) and azasilacyclopentane (ASCP) heteroatom cyclics have proven capable of rapidly converting hydroxylated surfaces to functionalized surfaces in inorganic click reactions. In this work, we demonstrate that the use of these reagents can be extended to “simultaneous double-clicking” when both inorganic and organic substrates are present at the onset of the reaction. The simultaneous double-click depends on a first ring-opening click with an inorganic substrate that is complete in &sim;1 s at 30&nbs

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47

Lin, Meiyun, Ammar Adam, Abira Pyne Ramakrishnan, et al. "Abstract 7185: Long acting injectable FHD-609 micro-suspension: A potent BRD9 degrader with comparable efficacy, reduced frequency of dosing in preclinical models." Cancer Research 84, no. 6_Supplement (2024): 7185. http://dx.doi.org/10.1158/1538-7445.am2024-7185.

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Abstract Bromodomain-containing protein 9 (BRD9) is a unique component of the non-canonical Brahma-associated factor (ncBAF) complex, essential for cancer cells relying on this complex for survival. This makes it an attractive target for cancer treatment. In synovial sarcoma (SS), SS18-SSX fusion protein drives disease progression and integrates into BAF complexes, promoting tumor growth. Targeting BRD9 degradation is a potential therapeutic approach for SS tumors, as it depletes the essential SS18-SSX fusion protein upon which cancer cells depend for survival within the BAF complex. FHD-609,

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48

Lotocki, Victor, Eloi Grignon, Harrison A. Mills, Shuyang Ye, Alan J. Lough, and Dwight S. Seferos. "A S_NAr‐Active External Initiator that Enables Heterobifunctional Clickable Polythiophenes." Macromolecular Chemistry and Physics, October 19, 2023. http://dx.doi.org/10.1002/macp.202300347.

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AbstractPoly(3‐hexylthiophene) (P3HT) is a well‐studied conjugated polymer, however, the end‐group functionalization of these polymers is limited by fundamental synthetic challenges. Generally, end‐capping agents are used to terminate the Kumada Catalyst Transfer Polycondensation (KCTP) to install functional end‐groups at the propagating chain end. In this work, we show that P3HT can be prepared with a novel SNAr‐active external initiator, followed by end capping to afford heterobifunctional end‐groups that exhibit orthogonal chemical reactivity. This orthogonal chemistry can be leveraged in s

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49

Grundler, Julian, Chang‐Hee Whang, Kwangsoo Shin, N. Anna Savan, Mingjiang Zhong, and W. Mark Saltzman. "Modifying the Backbone Chemistry of PEG‐based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles." Advanced Healthcare Materials, May 11, 2024. http://dx.doi.org/10.1002/adhm.202304040.

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AbstractNanoparticle physicochemical properties have received great attention in optimizing the performance of nanoparticles for biomedical applications. For example, surface functionalization with small molecules or linear hydrophilic polymers is commonly used to tune the interaction of nanoparticles with proteins and cells. However, it is challenging to control the location of functional groups within the shell for conventional nanoparticles. Nanoparticle surfaces composed of shape‐persistent bottlebrush polymers allow hierarchical control over the nanoparticle shell but the effect of the bo

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Liu, Yuxia, Tong Yang, Jinqiao Rong, et al. "Integrated analysis of natural glycans using a versatile pyrazolone-type heterobifunctional tag ANPMP." Carbohydrate Polymers, November 2023, 121617. http://dx.doi.org/10.1016/j.carbpol.2023.121617.

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